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Conserved domains on  [gi|8843890|dbj|BAA97416|]
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inorganic phosphate transporter [Arabidopsis thaliana]

Protein Classification

MFS transporter( domain architecture ID 1000614)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2A0109 super family cl31035
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
11-516 0e+00

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


The actual alignment was detected with superfamily member TIGR00887:

Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 716.12  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890     11 ALDVAKTQLY---HFTAIVIAGMGFFTDAYDLFCVSLVTKLLGRIYYfnpesAKPGSLPPHVAAAVNGVALCGTLSGQLF 87
Cdd:TIGR00887   1 ALEEADTAPFgwqHFRAIVIAGVGFFTDSYDLFCISLVTKMLGYVYY-----HGKGPLPSSVSAAVNGSASIGTLAGQLF 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890     88 FGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGNEAKGVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAA 167
Cdd:TIGR00887  76 FGWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSVMATLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAA 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    168 VFAMQGVGILAGGFVALAVSSIFDKKFPAPTYAVNRALSTPPQVDYIWRIIVMFGALPAALTYYWRMKMPETARYTALVA 247
Cdd:TIGR00887 156 VFAMQGFGILAGAIVALIVLAGFKHSLEAAADEASCTGSCVPAVDYMWRILIGFGAVPALLALYFRLTIPETPRYTADVA 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    248 KNIKQATADMSKVLQTDIELE----ERVEDDVKDPRQN-YGLFSKEFLRRHGLHLLGTTSTWFLLDIAFYSQNLFQKDIF 322
Cdd:TIGR00887 236 KDVEQAASDMSAVLQVKIEAEpdevEKASTAVEVPKASwSDFFTHFFKWRHGKHLLGTAGSWFLLDIAFYGVNLNQKVIL 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    323 SAIGWIPKAATMNATHEVFRIARAQTLIALCSTVPGYWFTVAFIDTIGRFKIQLNGFFMMTVFMFAIAFPYNHWIKPenr 402
Cdd:TIGR00887 316 SAIGYSPPAATNNAYEELYKTAVGNLIIALAGTVPGYWVTVFLVDIIGRKPIQLMGFFILTVLFFVLGFAYNHLSTH--- 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    403 iGFVVMYSLTFFFANFGPNATTFIVPAEIFPARLRSTCHGISAAAGKAGAIIGAFGFLYAAQNQDkakVDAGYPPGIGVK 482
Cdd:TIGR00887 393 -GFLAIYVLAQFFANFGPNATTFIVPGEVFPTRYRSTAHGISAASGKAGAIIGQFGFLYLAQHGD---PTKGYPTGIWMG 468
                         490       500       510
                  ....*....|....*....|....*....|....
gi 8843890    483 NSLIVLGVLNFIGMLFTFLVPEPKGKSLEELSGE 516
Cdd:TIGR00887 469 HVLEIFALFMFLGILFTLLIPETKGKSLEELSGE 502
 
Name Accession Description Interval E-value
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
11-516 0e+00

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 716.12  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890     11 ALDVAKTQLY---HFTAIVIAGMGFFTDAYDLFCVSLVTKLLGRIYYfnpesAKPGSLPPHVAAAVNGVALCGTLSGQLF 87
Cdd:TIGR00887   1 ALEEADTAPFgwqHFRAIVIAGVGFFTDSYDLFCISLVTKMLGYVYY-----HGKGPLPSSVSAAVNGSASIGTLAGQLF 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890     88 FGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGNEAKGVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAA 167
Cdd:TIGR00887  76 FGWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSVMATLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAA 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    168 VFAMQGVGILAGGFVALAVSSIFDKKFPAPTYAVNRALSTPPQVDYIWRIIVMFGALPAALTYYWRMKMPETARYTALVA 247
Cdd:TIGR00887 156 VFAMQGFGILAGAIVALIVLAGFKHSLEAAADEASCTGSCVPAVDYMWRILIGFGAVPALLALYFRLTIPETPRYTADVA 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    248 KNIKQATADMSKVLQTDIELE----ERVEDDVKDPRQN-YGLFSKEFLRRHGLHLLGTTSTWFLLDIAFYSQNLFQKDIF 322
Cdd:TIGR00887 236 KDVEQAASDMSAVLQVKIEAEpdevEKASTAVEVPKASwSDFFTHFFKWRHGKHLLGTAGSWFLLDIAFYGVNLNQKVIL 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    323 SAIGWIPKAATMNATHEVFRIARAQTLIALCSTVPGYWFTVAFIDTIGRFKIQLNGFFMMTVFMFAIAFPYNHWIKPenr 402
Cdd:TIGR00887 316 SAIGYSPPAATNNAYEELYKTAVGNLIIALAGTVPGYWVTVFLVDIIGRKPIQLMGFFILTVLFFVLGFAYNHLSTH--- 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    403 iGFVVMYSLTFFFANFGPNATTFIVPAEIFPARLRSTCHGISAAAGKAGAIIGAFGFLYAAQNQDkakVDAGYPPGIGVK 482
Cdd:TIGR00887 393 -GFLAIYVLAQFFANFGPNATTFIVPGEVFPTRYRSTAHGISAASGKAGAIIGQFGFLYLAQHGD---PTKGYPTGIWMG 468
                         490       500       510
                  ....*....|....*....|....*....|....
gi 8843890    483 NSLIVLGVLNFIGMLFTFLVPEPKGKSLEELSGE 516
Cdd:TIGR00887 469 HVLEIFALFMFLGILFTLLIPETKGKSLEELSGE 502
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
25-506 0e+00

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 518.37  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   25 IVIAGMGFFTDAYDLFCVSLVTKLLGRIYYFnpesaKPGSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLT 104
Cdd:cd17364   1 IIIAGMGFFTDAYDLFSISLVTKILGRLYYG-----GKGSLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVE 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  105 LIMMILCSVASGLSFGNEAKGVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAGGFVAL 184
Cdd:cd17364  76 LIIMIIGTILSALSPGSTPLGVMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  185 AVSSIFDKKFPAptyavnralSTPPQVDYIWRIIVMFGALPAALTYYWRmkmpetarytalvaknikqatadmskvlqtd 264
Cdd:cd17364 156 ILSAIFEHPLPA---------GTYHHADLVWRIVLGLGAIPALSVLYFR------------------------------- 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  265 ieleerveddvkdprqnyglfskeflrrhgLHLLGTTSTWFLLDIAFYSQNLFQKDIFSAIGWIpkaATMNATHEVFRIA 344
Cdd:cd17364 196 ------------------------------KHLLGTAGTWFLLDIAFYGQNLFQSTIISAIGFS---KTMNAYQELFNIA 242
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  345 RAQTLIALCSTVPGYWFTVAFIDTIGRFKIQLNGFFMMTVFMFAIAFPYNHWikPENRIGFVVMYSLTFFFANFGPNATT 424
Cdd:cd17364 243 VGQLIIALAGTVPGYWFTVFLIDRIGRKKIQMMGFFGMTIFLLILAGPYDHW--KISTIGFFVLYGLTFFFSNFGPNTTT 320
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  425 FIVPAEIFPARLRSTCHGISAAAGKAGAIIGAFGFLYAAQNqdkakvdagyppgIGVKNSLIVLGVLNFIGMLFTFLVPE 504
Cdd:cd17364 321 FIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQN-------------IGVRNVLIILAGVALLGIILTLLFPE 387

                ..
gi 8843890  505 PK 506
Cdd:cd17364 388 EK 389
Sugar_tr pfam00083
Sugar (and other) transporter;
26-514 4.09e-29

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 119.68  E-value: 4.09e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890     26 VIAGMGFFTDAYDLFCVSLVTKLLGRIYYFNP-ESAKPGSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLT 104
Cdd:pfam00083   3 LVAALGGFLFGYDTGVIGAFLTLIDFFKNFGLsKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    105 LIMMILCSVASGLSFGNEAKGVmttLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAavfaMQGVGILAGGFVAL 184
Cdd:pfam00083  83 NVLFVIGAVLQGAAKGKWSVYQ---LIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGS----LYQLAITFGILLAY 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    185 AVSSIFDKKFPAPTyavnralstppqvdyiWRIIVMFGALPAALTYYWRMKMPETARYTALVAKnIKQATADMSKVLQTD 264
Cdd:pfam00083 156 IFGLGLNKTSNSDG----------------WRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGR-LEEAREVLAKLRGVP 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    265 IELEERVE--DDVKDPRQNYGLFSKEFLRRHGLHllGTTSTWFLLDIA----------FYSQNLFQKDIFSaigwipkaa 332
Cdd:pfam00083 219 DVDRELDEikDSLEAGQEAEKASWKELFSTKTRR--QRLLIGVMLQIFqqltginaifYYSTTIFENLGLS--------- 287
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    333 tmnathEVFRIARAQTLIALCSTVPGYWFtvafIDTIGRFKIQLNGFFMMTVFMF---AIAFPYNHwIKPENRIGFVVMY 409
Cdd:pfam00083 288 ------DSFLVTIIVGVVNFVFTFIAIFL----VDRFGRRPLLLLGAAGMAICFVilgIVALLGVS-KSDWAGIVAIVFI 356
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    410 SLTFFFANFGPNATTFIVPAEIFPARLRSTCHGISAAAGKAGAIIGAFGFLYAAQNqdkakvdagyppgIGVKNSLIVLG 489
Cdd:pfam00083 357 ALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDA-------------IGLGYTFFIFA 423
                         490       500
                  ....*....|....*....|....*.
gi 8843890    490 VLNFIGMLFTFL-VPEPKGKSLEELS 514
Cdd:pfam00083 424 GLLVLFIIFVFFfVPETKGRTLEEID 449
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
21-247 1.41e-24

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 103.74  E-value: 1.41e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   21 HFTAIVIAGMGFFTDAYDLFCVSLVTKLLGRIYyfnpesakpgSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKV 100
Cdd:COG0477  12 RRRALLALALGTFLEGLDFTIVNVALPSIAADL----------GASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  101 YGLTLIMMILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAGG 180
Cdd:COG0477  82 LLIGLLLFGLASLLCGLAPS------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGP 155
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 8843890  181 FVALAVSSIFDkkfpaptyavnralstppqvdyiWRIIVMFGALPAALTYYWRMKMPETARYTALVA 247
Cdd:COG0477 156 LLGGLLVAALG-----------------------WRWIFLINAPLGLLALVLRLRLPESRGLLLALL 199
PRK10642 PRK10642
proline/glycine betaine transporter ProP;
24-248 3.76e-10

proline/glycine betaine transporter ProP;


Pssm-ID: 182611 [Multi-domain]  Cd Length: 490  Bit Score: 62.04  E-value: 3.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    24 AIVIAGMGFFTDAYDLFCVSLVTKLLGRIYYfnpesakPGSLPphvaaAVNGVALCGTLS--------GQLFFGWLGDKL 95
Cdd:PRK10642  17 AITAASLGNAMEWFDFGVYGFVAYALGKVFF-------PGADP-----SVQMIAALATFSvpflirplGGLFFGMLGDKY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    96 GRKKVYGLTLIMMILCSVASGLSFGNEAKGVMTT--LCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGaFIAAVFAMQG 173
Cdd:PRK10642  85 GRQKILAITIVIMSISTFCIGLIPSYATIGIWAPilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRG-FMGSWLDFGS 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 8843890   174 VG--ILAGGFVALAVSSIFDKKFpaptyavnralstppqVDYIWRiIVMFGALPAALT-YYWRMKMPETARYTALVAK 248
Cdd:PRK10642 164 IAgfVLGAGVVVLISTIVGEANF----------------LDWGWR-IPFFIALPLGIIgLYLRHALEETPAFQQHVDK 224
 
Name Accession Description Interval E-value
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
11-516 0e+00

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 716.12  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890     11 ALDVAKTQLY---HFTAIVIAGMGFFTDAYDLFCVSLVTKLLGRIYYfnpesAKPGSLPPHVAAAVNGVALCGTLSGQLF 87
Cdd:TIGR00887   1 ALEEADTAPFgwqHFRAIVIAGVGFFTDSYDLFCISLVTKMLGYVYY-----HGKGPLPSSVSAAVNGSASIGTLAGQLF 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890     88 FGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGNEAKGVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAA 167
Cdd:TIGR00887  76 FGWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSVMATLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAA 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    168 VFAMQGVGILAGGFVALAVSSIFDKKFPAPTYAVNRALSTPPQVDYIWRIIVMFGALPAALTYYWRMKMPETARYTALVA 247
Cdd:TIGR00887 156 VFAMQGFGILAGAIVALIVLAGFKHSLEAAADEASCTGSCVPAVDYMWRILIGFGAVPALLALYFRLTIPETPRYTADVA 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    248 KNIKQATADMSKVLQTDIELE----ERVEDDVKDPRQN-YGLFSKEFLRRHGLHLLGTTSTWFLLDIAFYSQNLFQKDIF 322
Cdd:TIGR00887 236 KDVEQAASDMSAVLQVKIEAEpdevEKASTAVEVPKASwSDFFTHFFKWRHGKHLLGTAGSWFLLDIAFYGVNLNQKVIL 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    323 SAIGWIPKAATMNATHEVFRIARAQTLIALCSTVPGYWFTVAFIDTIGRFKIQLNGFFMMTVFMFAIAFPYNHWIKPenr 402
Cdd:TIGR00887 316 SAIGYSPPAATNNAYEELYKTAVGNLIIALAGTVPGYWVTVFLVDIIGRKPIQLMGFFILTVLFFVLGFAYNHLSTH--- 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    403 iGFVVMYSLTFFFANFGPNATTFIVPAEIFPARLRSTCHGISAAAGKAGAIIGAFGFLYAAQNQDkakVDAGYPPGIGVK 482
Cdd:TIGR00887 393 -GFLAIYVLAQFFANFGPNATTFIVPGEVFPTRYRSTAHGISAASGKAGAIIGQFGFLYLAQHGD---PTKGYPTGIWMG 468
                         490       500       510
                  ....*....|....*....|....*....|....
gi 8843890    483 NSLIVLGVLNFIGMLFTFLVPEPKGKSLEELSGE 516
Cdd:TIGR00887 469 HVLEIFALFMFLGILFTLLIPETKGKSLEELSGE 502
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
25-506 0e+00

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 518.37  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   25 IVIAGMGFFTDAYDLFCVSLVTKLLGRIYYFnpesaKPGSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLT 104
Cdd:cd17364   1 IIIAGMGFFTDAYDLFSISLVTKILGRLYYG-----GKGSLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVE 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  105 LIMMILCSVASGLSFGNEAKGVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAGGFVAL 184
Cdd:cd17364  76 LIIMIIGTILSALSPGSTPLGVMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  185 AVSSIFDKKFPAptyavnralSTPPQVDYIWRIIVMFGALPAALTYYWRmkmpetarytalvaknikqatadmskvlqtd 264
Cdd:cd17364 156 ILSAIFEHPLPA---------GTYHHADLVWRIVLGLGAIPALSVLYFR------------------------------- 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  265 ieleerveddvkdprqnyglfskeflrrhgLHLLGTTSTWFLLDIAFYSQNLFQKDIFSAIGWIpkaATMNATHEVFRIA 344
Cdd:cd17364 196 ------------------------------KHLLGTAGTWFLLDIAFYGQNLFQSTIISAIGFS---KTMNAYQELFNIA 242
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  345 RAQTLIALCSTVPGYWFTVAFIDTIGRFKIQLNGFFMMTVFMFAIAFPYNHWikPENRIGFVVMYSLTFFFANFGPNATT 424
Cdd:cd17364 243 VGQLIIALAGTVPGYWFTVFLIDRIGRKKIQMMGFFGMTIFLLILAGPYDHW--KISTIGFFVLYGLTFFFSNFGPNTTT 320
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  425 FIVPAEIFPARLRSTCHGISAAAGKAGAIIGAFGFLYAAQNqdkakvdagyppgIGVKNSLIVLGVLNFIGMLFTFLVPE 504
Cdd:cd17364 321 FIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQN-------------IGVRNVLIILAGVALLGIILTLLFPE 387

                ..
gi 8843890  505 PK 506
Cdd:cd17364 388 EK 389
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
25-439 1.73e-35

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 135.81  E-value: 1.73e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   25 IVIAGMGFFTDAYDLFCVSLVTKLLGRIYYFNpesakpgsLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLT 104
Cdd:cd17316   1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLG--------LSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILT 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  105 LIMMILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAGGFVAL 184
Cdd:cd17316  73 LLLFGLATLLIGLLPT------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVAS 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  185 AVSSIFDKkfpaptyavnralstppqvDYIWRIIVMFGALPAALTYYWRMKMpetarytalvaknikqatadmskvlqtd 264
Cdd:cd17316 147 LLIPLLSG-------------------DWGWRILFLIGALPALLALLLRRRT---------------------------- 179
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  265 ieleerveddvkdprqnyglfskeflrrhglhlLGTTSTWFLLDIAFYSQNLFQKDIFSAIGWIPKAATMNAthevfria 344
Cdd:cd17316 180 ---------------------------------LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLY-------- 218
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  345 raqTLIALCSTVPGYWFTVAFIDTIGRFKIQLNGFFMMTVFMFAIAFPynhwikPENRIGFVVMYSLTFFFANFGPNATT 424
Cdd:cd17316 219 ---LLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYL------LSGSPTLLLLLLFILSFFVGGVWGAL 289
                       410
                ....*....|....*
gi 8843890  425 FIVPAEIFPARLRST 439
Cdd:cd17316 290 YAYLAELFPTEVRAT 304
Sugar_tr pfam00083
Sugar (and other) transporter;
26-514 4.09e-29

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 119.68  E-value: 4.09e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890     26 VIAGMGFFTDAYDLFCVSLVTKLLGRIYYFNP-ESAKPGSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLT 104
Cdd:pfam00083   3 LVAALGGFLFGYDTGVIGAFLTLIDFFKNFGLsKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    105 LIMMILCSVASGLSFGNEAKGVmttLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAavfaMQGVGILAGGFVAL 184
Cdd:pfam00083  83 NVLFVIGAVLQGAAKGKWSVYQ---LIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGS----LYQLAITFGILLAY 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    185 AVSSIFDKKFPAPTyavnralstppqvdyiWRIIVMFGALPAALTYYWRMKMPETARYTALVAKnIKQATADMSKVLQTD 264
Cdd:pfam00083 156 IFGLGLNKTSNSDG----------------WRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGR-LEEAREVLAKLRGVP 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    265 IELEERVE--DDVKDPRQNYGLFSKEFLRRHGLHllGTTSTWFLLDIA----------FYSQNLFQKDIFSaigwipkaa 332
Cdd:pfam00083 219 DVDRELDEikDSLEAGQEAEKASWKELFSTKTRR--QRLLIGVMLQIFqqltginaifYYSTTIFENLGLS--------- 287
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    333 tmnathEVFRIARAQTLIALCSTVPGYWFtvafIDTIGRFKIQLNGFFMMTVFMF---AIAFPYNHwIKPENRIGFVVMY 409
Cdd:pfam00083 288 ------DSFLVTIIVGVVNFVFTFIAIFL----VDRFGRRPLLLLGAAGMAICFVilgIVALLGVS-KSDWAGIVAIVFI 356
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    410 SLTFFFANFGPNATTFIVPAEIFPARLRSTCHGISAAAGKAGAIIGAFGFLYAAQNqdkakvdagyppgIGVKNSLIVLG 489
Cdd:pfam00083 357 ALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDA-------------IGLGYTFFIFA 423
                         490       500
                  ....*....|....*....|....*.
gi 8843890    490 VLNFIGMLFTFL-VPEPKGKSLEELS 514
Cdd:pfam00083 424 GLLVLFIIFVFFfVPETKGRTLEEID 449
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
21-247 1.41e-24

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 103.74  E-value: 1.41e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   21 HFTAIVIAGMGFFTDAYDLFCVSLVTKLLGRIYyfnpesakpgSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKV 100
Cdd:COG0477  12 RRRALLALALGTFLEGLDFTIVNVALPSIAADL----------GASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  101 YGLTLIMMILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAGG 180
Cdd:COG0477  82 LLIGLLLFGLASLLCGLAPS------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGP 155
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 8843890  181 FVALAVSSIFDkkfpaptyavnralstppqvdyiWRIIVMFGALPAALTYYWRMKMPETARYTALVA 247
Cdd:COG0477 156 LLGGLLVAALG-----------------------WRWIFLINAPLGLLALVLRLRLPESRGLLLALL 199
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
80-513 5.06e-19

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 89.71  E-value: 5.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890     80 GTLSGQLFFGWLGDKLGRKKvyglTLIMMILCSVASGLSFGNEAKG-VMTTLCFFRFWLGFGIGGDYPLSATIMSEYANK 158
Cdd:TIGR00879  83 GGFIGALFAGWLSDRFGRKK----SLLIIALLFVIGAILMGLAAFAlSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPK 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    159 KTRGAFIaavfAMQGVGILAGGFVALAVssifdkkfpapTYAVNRALST-----PPQVDYIWRIIvMFGALPAAltyywr 233
Cdd:TIGR00879 159 ALRGALT----SLYQLAITFGILVAYGF-----------GSGKVSLNNTlgwriPLGLQLIPAGL-LFLGLFFL------ 216
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    234 mkmPETARYtaLVAKN-IKQATADMSKVLQTDIE-LEERVEDDVKDPRQNYglfSKEFLRRHGLHLLGTTSTWFLLDIAF 311
Cdd:TIGR00879 217 ---PESPRW--LVGKGrVEEARKSLARLRGTSGEdKELLDELELIDIKRSI---EKRSVQPSWGSLFSSTRRIRRRLFLG 288
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    312 YSQNLFQKdiFSAIgwipkAATMNATHEVFRIARAQTLIALCSTVPGYWFTVAF-------IDTIGRFKIQLNGFFMMTV 384
Cdd:TIGR00879 289 VVLQWFQQ--FTGI-----NAIMYYSPTIFENAGVSTDHAFLVSIIVGAVNFAFtfvaiflVDRFGRRPLLLIGAAGMAI 361
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    385 FMFAIA---FPYNHWIKPENRIGFVVMYSLTFFFANFGPNATTFIVPAEIFPARLRSTCHGISAAAGKAGAIIGAFGFLY 461
Cdd:TIGR00879 362 CLFVLGilgASFVTGSSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPT 441
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 8843890    462 AAQNqdkakvdagyppgIGVKNSLIVLGVLNFIGMLFT-FLVPEPKGKSLEEL 513
Cdd:TIGR00879 442 MLES-------------IGVGGVFIFFGGLNVLGLIFVyFFLPETKGRTLEEI 481
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
8-439 2.95e-18

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 86.64  E-value: 2.95e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890      8 VLKALDVAKTQLYHFTAIVIAGMGFFTDAYDLFCVSLVTKLLGRiyYFNPESAKPGSLpphVAAAVNGVALcgtlsGQLF 87
Cdd:TIGR00895   2 VQNNIRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISA--EWGLDPVQLGFL---FSAGLIGMAF-----GALF 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890     88 FGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAA 167
Cdd:TIGR00895  72 FGPLADRIGRRRVLLWSILLFSVFTLLCALATN------VTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGL 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    168 VFAMQGVGILAGGFVALAVSSIFDkkfpaptyavnralstppqvdyiWRIIVMFGAL-PAALTYYWRMKMPETARYtaLV 246
Cdd:TIGR00895 146 MFCGYPIGAAVGGFLAGWLIPVFG-----------------------WRSLFYVGGIaPLLLLLLLMRFLPESIDF--LV 200
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    247 AKNIKQATADMSKVL-------QTDIELEERVEDDVKDPRQnyGLFSKEFLRRHGLHLLGTtstwFLLDIAFYsqnlfqk 319
Cdd:TIGR00895 201 SKRPETVRRIVNAIApqmqaeaQSALPEQKSTQGTKRSVFK--ALFQGKTARITVLLWLLY----FMLLVGVY------- 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    320 difSAIGWIPK---AATMNATHEVFRIARAQtlialCSTVPGYWFTVAFIDTIGRfKIQLNGFFMMTVFMFAIAFPYNHw 396
Cdd:TIGR00895 268 ---FLTNWLPKlmvELGFSLSLAATGGALFN-----FGGVIGSIIFGWLADRLGP-RVTALLLLLGAVFAVLVGSTLFS- 337
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 8843890    397 ikpenrigFVVMYSLTFFFANF--GPNATTFIVPAEIFPARLRST 439
Cdd:TIGR00895 338 --------PTLLLLLGAIAGFFvnGGQSGLYALMALFYPTAIRAT 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
24-439 1.68e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 83.87  E-value: 1.68e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   24 AIVIAGMGFFTDAYDLFCVSLVTKLLGRIYyfnpesakpgSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGL 103
Cdd:COG2814  11 ALLALALGAFLSGLGIGIVLPALPLIAADL----------GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  104 TLIMMILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAGGFVA 183
Cdd:COG2814  81 GLLLFALGSLLCALAPS------LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLG 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  184 LAVSSIFDkkfpaptyavnralstppqvdyiWRIIVMFGALPAALTYYW-RMKMPETARytalvaknikqatadmskvlQ 262
Cdd:COG2814 155 GLLADLFG-----------------------WRWVFLVNAVLALLALLLlLRLLPESRP--------------------A 191
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  263 TDIELEERVEDDVKDPRqnyglfskeflrrhglhLLGTTSTWFLLDIAFysqnlfqkdiFSAIGWIPKAATMNATHEVFR 342
Cdd:COG2814 192 ARARLRGSLRELLRRPR-----------------LLLLLLLAFLLGFGF----------FALFTYLPLYLQEVLGLSASA 244
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  343 IARAQTLIALCSTVpGYWFTVAFIDTIGRFKIQLNGFFMMTVFMFAIAFPYNHWikpenrIGFVVMYSLTFFFANFGPNA 422
Cdd:COG2814 245 AGLLLALFGLGGVL-GALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLW------LLLLALFLLGFGFGLLFPLL 317
                       410
                ....*....|....*..
gi 8843890  423 TTFIvpAEIFPARLRST 439
Cdd:COG2814 318 QALV--AELAPPEARGR 332
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
26-440 1.84e-16

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 81.19  E-value: 1.84e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   26 VIAGMGFFTDAYDLFCVSLVTKLLgrIYYFNPESAKPGSLpphvaaavNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTL 105
Cdd:cd17371   2 WAAFLGWALDGFDLLLLGLVLPAL--IAEFGLDEAEAGLL--------GTVTLAGGAIGGILGGILADRFGRVRVLVITI 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  106 IMMILCSVASGLSfgneakGVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAGGFVALA 185
Cdd:cd17371  72 LLFAVFTLLCGFA------QNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAAL 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  186 VSSIFDKKFPaptyavnralstppqvdyiWRIIVMFGALPAALTYYWRMKMPETARYTAlvAKNIKQATADMSKVlqtdi 265
Cdd:cd17371 146 LFPLLPPEIA-------------------WRVLFLLGALPALLVLFIRRFVKEPPQWQA--ARAARRHFADRPSL----- 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  266 eleerveddvkdprqnYGLFSKEFLRrhglhllgTTSTWFLLDIAFYSQNlfqkdiFSAIGWIPKAATMNATHEVFRIAR 345
Cdd:cd17371 200 ----------------RELFSPPLLR--------TTLLASLLATGALGGY------YGITTWLPSYLTGERGLSFEGSAG 249
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  346 AQTLIALCSTVpGYWFTVAFIDTIGRFKIQLNGFFMMTVFMFAIAFpynhwiKPENRIGFVVMYSLTFFFAnFGPNATTF 425
Cdd:cd17371 250 YLVVTILGGFL-GYLAGGFLADRIGRRNNFALFALGSAISILLYFF------LPLSPTLILILGFPLGFFA-SGPFSGMG 321
                       410
                ....*....|....*
gi 8843890  426 IVPAEIFPARLRSTC 440
Cdd:cd17371 322 AYLTELFPTAVRATA 336
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
84-439 2.55e-16

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 81.03  E-value: 2.55e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   84 GQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGNEAKGVMTT--LCFFRFWLGFGIGGDYPLSATIMSEYANKKTR 161
Cdd:cd17369  60 GGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQIGILAPilLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRR 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  162 GaFIAAVFAMqgvGILAGGFVALAVSSIfdkkfpaptyaVNRALSTPPQVDYIWRIIVMFGALPAALTYYWRMKMPETAR 241
Cdd:cd17369 140 G-FYGSFPQL---GAPVGLLLATGVFLL-----------LSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPV 204
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  242 YTALVAKNiKQATADMSKVLQTDieleerveddvkdprqnyglfSKEFLRRHGLhLLGTTSTWFLldIAFYSQNLFQKdi 321
Cdd:cd17369 205 FRRAKEAG-QVVRAPLVEVLRRH---------------------WRALLLAIGL-RLAENVLFYL--FTTFALSYATQ-- 257
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  322 fsaIGWIPKAATMNAthevfriaraqTLIALCSTVPGYWFTVAFIDTIGRFKIqlngFFMMTVFMFAIAFPYNHWIKPEN 401
Cdd:cd17369 258 ---TLGVDRSTVLLA-----------VLIASVVAAITIPLFGWLSDRVGRRPV----YLAGALLAALFAFPFFWLLDTGS 319
                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 8843890  402 RIGFVVMYSLTFFFAN---FGPNATTFivpAEIFPARLRST 439
Cdd:cd17369 320 TWLIVLAAVVVLGVLHgmmYGPQAAFL---AELFPTRVRYT 357
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
84-439 1.57e-15

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 78.49  E-value: 1.57e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   84 GQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGNEAKGVMTT--LCFFRFWLGFGIGGDYPLSATIMSEYANKKTR 161
Cdd:cd17367  56 GGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATIGIWAPiiLLLARLLQGLSVGGEYGTSATYLSEVAPPGRR 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  162 GAFIAAVFAMQGVGILAGGFVALAVSSIFdkkfpaptyavnralsTPPQV-DYIWRIIVMFGALPAALTYYWRMKMPETA 240
Cdd:cd17367 136 GFYSSFQYVTLIGGQLLALGVLLVLQHTL----------------GEDQMaAWGWRIPFLLGGVLAVVVLWLRRGLEETE 199
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  241 RYTAlvAKNIKQATADMSKVLqtdieleerveddVKDPRqnyglfskEFLRRHGLHLLGTtstwflldIAFYSQNLF-QK 319
Cdd:cd17367 200 SFEA--IAESNEASAGTLREL-------------RRHPR--------ELLLVVGLTAGGT--------LAFYTWTTYlQK 248
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  320 DIFSAIGWIPKAATmnathevfrIARAQTLIALCSTVPgywFTVAFIDTIGRFKIQLNGFFMMTVFMFAIAFPYNHWIKP 399
Cdd:cd17367 249 FLVNTAGFSKGDAT---------WITTAALLVFMLLQP---LGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSP 316
                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 8843890  400 eNRIGFVVMYSLTFFFANFGPNAttfIVPAEIFPARLRST 439
Cdd:cd17367 317 -YTAFALVLVGLVFLSGYTSINA---VVKAELFPTHVRAL 352
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
65-228 1.77e-14

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 74.93  E-value: 1.77e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   65 LPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSfgneakGVMTTLCFFRFWLGFGIGGD 144
Cdd:cd17365  31 LSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFA------QSVLQLALLRFLTGLGLGAA 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  145 YPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAGGFVALAVssifdkkfpAPTYAvnralstppqvdyiWRIIVMFGAL 224
Cdd:cd17365 105 MPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAAL---------IPAFG--------------WRSVFLLGGV 161

                ....
gi 8843890  225 PAAL 228
Cdd:cd17365 162 PPLI 165
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
73-437 3.77e-14

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 74.14  E-value: 3.77e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   73 VNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFgneakgVMTTLCFFRFWLGFGIGGDYPLSATIM 152
Cdd:cd17359  41 VVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSP------NFTIFIIARIIGGLAVGGASALVPMYI 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  153 SEYANKKTRGAFIaavfAMQGVGILAGGFVALAVssifdkkfpapTYAVNRALSTPPQVDYIWRIIVMFGALPAALTYYW 232
Cdd:cd17359 115 AEVAPAEIRGRLV----SLNQLMIVFGQLLAYIV-----------NYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLG 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  233 RMKMPETARYtaLVAKNikqatadmSKVLQTDIELeerveddvkdprqnyGLFSKeflrrhglhLLGTTStwflldIAFY 312
Cdd:cd17359 180 MLFIPESPRW--LVSKG--------KPILIIGIGL---------------AIFQQ---------FVGINV------IFYY 219
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  313 SQNLFQKDIFSAigwipKAATMnathevfriarAQTLIALCSTVpGYWFTVAFIDTIGRFKIQLNGFFMMTVFMFAIAfp 392
Cdd:cd17359 220 GPEIFQNAGFSE-----NAALL-----------QTIGIGVVNVI-FTIIAILLVDKVGRKPLLLIGSIGMAISLLLIG-- 280
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
gi 8843890  393 YNHWIKPENRIGFVVMYSLTFFFANF-----GPnaTTFIVPAEIFPARLR 437
Cdd:cd17359 281 TAFYFAPGSQASGIVALVLILLFVAFfamswGP--VTWVLLSEIFPNRIR 328
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
80-512 8.23e-14

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 73.38  E-value: 8.23e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   80 GTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVAsgLSFgneAKGVMtTLCFFRFWLGFGIGGDYPLSATIMSEYANKK 159
Cdd:cd17358  53 GALIGALLSGKLADRIGRKRTLLISAIPCILGWLL--IAF---AKDVW-MLYLGRFLAGFGGGAASVVVPVYIAEIAPKN 126
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  160 TRGAFIAAVFAMQGVGILAGGFVALAVSsifdkkfpaptyavnralstppqvdyiWRIIVMFGALPAALTYYWRMKMPET 239
Cdd:cd17358 127 VRGALGSLNQLLVNIGILLGYVLGSFLP---------------------------WRTLALIGAIPPVVFLILLFFIPES 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  240 ARYTALVaKNIKQAtadmSKVLQ--------TDIELEERVEDDVKDPRQNYGLFSKEFLRRHGLHLLGTTSTWFLLD--- 308
Cdd:cd17358 180 PRWLAKK-GREEEA----EKSLQflrgkdadISKEAAEIQEELAELEKEAKESSFSDLFQRKYLKPLVIGLGLMLFQqls 254
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  309 ----IAFYSQNLFQKdifSAIGWIPKAATMnathevfRIARAQTLIALCSTVpgywftvaFIDTIGRFKIQLNGFFMMTV 384
Cdd:cd17358 255 ginaVIFYASSIFDE---AGSGLDPNTATI-------IIGVVQVVGTLVATL--------LVDRLGRRPLLLVSAIGMGI 316
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  385 FMFAIA--FPYNHWIKPENRIGFVVMYSLTFF--FANFGPNATTFIVPAEIFPARLRSTchgiSAAAGKAGAIIGAFGFL 460
Cdd:cd17358 317 GLLALGlyFYLQEHGALLSSVSWLPLVGLVIYiiSFSIGLGPLPWVIMSEIFPAKIKGL----AGSLVTLVNWLFAFIVT 392
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 8843890  461 YAAQNQDKAkvdagyppgIGVKNSLIVLGVLNFIGMLFT-FLVPEPKGKSLEE 512
Cdd:cd17358 393 KTFPFLTLA---------WGASGTFWIFAGICGLALVFVlLFVPETKGKSLEE 436
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
80-512 1.34e-13

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 73.13  E-value: 1.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890     80 GTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSfgneakGVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKK 159
Cdd:TIGR00898 139 GVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFS------PNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKK 212
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    160 TRGAFIAAVFAMQGVGILAGGFVALAVSSifdkkfpaptyavnralstppqvdyiWRIIVMFGALP--AALTYYWRMkmP 237
Cdd:TIGR00898 213 QRAIVGTLIQVFFSLGLVLLPLVAYFIPD--------------------------WRWLQLAVSLPtfLFFLLSWFV--P 264
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    238 ETARYTAL-----VAKNIKQATADMSKVLQTDIELEERVEDDVKDPRQNYG---LFSKEFLRRHGLHLLgttSTWFLLDI 309
Cdd:TIGR00898 265 ESPRWLISqgrieEALKILQRIAKINGKKLPAEVLSLSLEKDLSSSKKQYSfldLFRTPNLRKTTLCLM---MLWFTTAF 341
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    310 AFYSQNLFQKDIFSAIGWIpkaatmnathevfriaraQTLIALcSTVPGYWFTVAFIDTIGRFKIQLNGFFMMTVFMFAI 389
Cdd:TIGR00898 342 SYYGLVLDLGNLGGNIYLD------------------LFISGL-VELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLL 402
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    390 AF--PYNHWIkpenRIGFVVmysLTFFFANFGPNATtFIVPAEIFPARLRSTCHGISAAAGKAGAIIGAFGFLYAAQNQd 467
Cdd:TIGR00898 403 LFvpVDLYFL----RTALAV---LGKFGITSAFQMV-YLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWL- 473
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 8843890    468 kakvdagYPPgigvknsLIVLGVLNFIGMLFTFLVPEPKGKSLEE 512
Cdd:TIGR00898 474 -------FLP-------LVLFGGLALLAGILTLFLPETKGVPLPE 504
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
20-191 1.62e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 71.82  E-value: 1.62e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   20 YHFTAIVIAGMGFFTDAYDLFCVSLVTKLLGRIYyfnpesakpgSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKK 99
Cdd:COG2271   7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADL----------GLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRR 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  100 VYGLTLIMMILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAG 179
Cdd:COG2271  77 VLAIGLLLWGLATLLFGFATS------FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALA 150
                       170
                ....*....|..
gi 8843890  180 GFVALAVSSIFD 191
Cdd:COG2271 151 PPLLGWLLAAFG 162
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
28-439 2.83e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 65.14  E-value: 2.83e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   28 AGMGFFTDAYDLFCVSLVTKLLGRIYYFNPEsakpgslpphVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIM 107
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSAS----------QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLL 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  108 MILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAGGFVALAVS 187
Cdd:cd06174  71 FALGALLFAFAPS------FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  188 SIFdkkfpaptyavnralstppqvDYIWRIIVMFGALPAALTYYWRMKMPEtarytalvaknikqatadmskvlqtDIEL 267
Cdd:cd06174 145 SSL---------------------GFGWRAVFLIAAALALLAAILLLLVVP-------------------------DPPE 178
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  268 EERVEDDVKDPRQNYGLFSKEFLRRhglHLLGTTSTWFLLDIAFYSQNLFQKDIFSAIGWIPKAATMNAthevfriaraq 347
Cdd:cd06174 179 SARAKNEEASSKSVLKLLKRVLKNP---GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLL----------- 244
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  348 TLIALCSTVPGYWFTVAFID-TIGRFKIQLNGFFMMTVFMFAIAFPYNHWIkpenrigFVVMYSLTFFFAnFGPNATTFI 426
Cdd:cd06174 245 LSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLL-------LLLLLLLLGFGL-GGLLPLSFA 316
                       410
                ....*....|...
gi 8843890  427 VPAEIFPARLRST 439
Cdd:cd06174 317 LIAELFPPEIRGT 329
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
25-513 1.50e-10

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 63.04  E-value: 1.50e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   25 IVIAGMGFFTDAYDLFCVSLVTKLLGRIYYFNPESAKPGSLPPHVAAAVNGVALcGTLSGQLFFGWLGDKLGRKKVYGLT 104
Cdd:cd17356   3 CAFVSLGGFLFGYDTGSISGILNMKSFQKYFADNTGTYYPSSSRQGLIVSIVNL-GSFFGALISSFLSDRIGRKKSIQIG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  105 LIMMILCSVASGLSFGNEAkgvmttlCFF--RFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAavfaMQGVGILAGGFV 182
Cdd:cd17356  82 CVIYIIGAIIQVAAIGKWY-------QLIvgRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVS----LYQLAITIGILV 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  183 ALAVSSIFDKKFPAPTYAVnralstPPQVDYIWRIIVMFGALpaaltyywrmKMPETARYtalvaknikqatadmskvlq 262
Cdd:cd17356 151 AYCINYGTHKLDGSAQWRI------PLGLQIVWGLLLLIGMF----------FLPESPRW-------------------- 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  263 tdieleerveddvkdprqnyglfskefLRRHglhLLGTTSTWFL----LDIAFYsqnlFQKDIFSAIGWIPKaatmnath 338
Cdd:cd17356 195 ---------------------------LYRT---ILGIMLQLFQqltgINYFFY----YGTTIFQSTGLTGS-------- 232
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  339 EVFRIARAQTLIALCSTVPGYWFtvafIDTIGRFKIQLNGFFMMTVFMFAIAF------PYNHWIKPENRIGFVVMYSLT 412
Cdd:cd17356 233 SPLLTSIILYIVNFVSTIPGLFF----VDKFGRRTCLLIGAAGMSICLFIYAAvgvrylIPNPQSGTSNKSAGNGMIVFI 308
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  413 FFF-ANFGP--NATTFIVPAEIFPARLRSTChgisaaAGKAGAIIGAFGFLYA-----AQNQDKAKVdagyppgigvkns 484
Cdd:cd17356 309 CLFiFSFATtwGPIAWVYVAEVFPLRVRSKG------MALATAFNWLWNFLISfftpfIIGSIGFKY------------- 369
                       490       500       510
                ....*....|....*....|....*....|
gi 8843890  485 LIVLGVLNFIGMLFT-FLVPEPKGKSLEEL 513
Cdd:cd17356 370 YYIFAGCNLLAFIVVfFFVPETKGLTLEEI 399
MFS_1 pfam07690
Major Facilitator Superfamily;
65-190 2.36e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 62.05  E-value: 2.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890     65 LPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGD 144
Cdd:pfam07690  29 ISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS------LWLLLVLRVLQGLGAGAL 102
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 8843890    145 YPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAGGFVALAVSSIF 190
Cdd:pfam07690 103 FPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF 148
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
20-249 2.68e-10

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 63.07  E-value: 2.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890     20 YHFTAIVIAGMGFFTDAYDLFCVSLVTkllgriyyfnPESAKPGSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKK 99
Cdd:TIGR01299 164 FQWALFFVLGLALMADGVEVFVVGFVL----------PSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQ 233
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    100 VygltliMMILCSVASGLSFGNEAKGVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIA--AVFAMQGvGIL 177
Cdd:TIGR01299 234 C------LLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSwlCMFWMIG-GIY 306
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 8843890    178 AGgfvALAVSSIfdkkfpaPTYAVNRALSTPPQVdYIWRIIVMFGALPAALTYYWRMKMPETARYTALVAKN 249
Cdd:TIGR01299 307 AA---AMAWAII-------PHYGWSFQMGSAYQF-HSWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKH 367
PRK10642 PRK10642
proline/glycine betaine transporter ProP;
24-248 3.76e-10

proline/glycine betaine transporter ProP;


Pssm-ID: 182611 [Multi-domain]  Cd Length: 490  Bit Score: 62.04  E-value: 3.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    24 AIVIAGMGFFTDAYDLFCVSLVTKLLGRIYYfnpesakPGSLPphvaaAVNGVALCGTLS--------GQLFFGWLGDKL 95
Cdd:PRK10642  17 AITAASLGNAMEWFDFGVYGFVAYALGKVFF-------PGADP-----SVQMIAALATFSvpflirplGGLFFGMLGDKY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    96 GRKKVYGLTLIMMILCSVASGLSFGNEAKGVMTT--LCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGaFIAAVFAMQG 173
Cdd:PRK10642  85 GRQKILAITIVIMSISTFCIGLIPSYATIGIWAPilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRG-FMGSWLDFGS 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 8843890   174 VG--ILAGGFVALAVSSIFDKKFpaptyavnralstppqVDYIWRiIVMFGALPAALT-YYWRMKMPETARYTALVAK 248
Cdd:PRK10642 164 IAgfVLGAGVVVLISTIVGEANF----------------LDWGWR-IPFFIALPLGIIgLYLRHALEETPAFQQHVDK 224
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
27-440 6.56e-10

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 60.67  E-value: 6.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   27 IAGMGFFTDAYDLFCVSLVTKLLGRIYYFnpesakpgSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLI 106
Cdd:cd17315   1 VAALGGLLFGYDLGVINGALLYIAKDLGF--------GLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAV 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  107 MMILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIaavfAMQGVGILAGGFVALAV 186
Cdd:cd17315  73 LYVIGALLSALAPN------VWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALG----TLNQLMITFGILLAYLL 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  187 SsifdkkFPAPTYAVNRalstppqvdyiWRIIVMFGALPAALTYYWRMKMPEtarytalvaknikqatadmSKVLQTDIE 266
Cdd:cd17315 143 G------LALSLSPPGW-----------WRLMFALAAVPALLQLLLMFFLPE-------------------SRALLVGVG 186
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  267 LeerveddvkdprqnyglfskeflrrhglhllgttstwflldiafysqNLFQKdiFSAIGwipkaATMNATHEVFRIARA 346
Cdd:cd17315 187 L-----------------------------------------------QLLQQ--LTGIN-----AVMYYAPTIFKSAGG 212
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  347 QTLIALCSTVPGYWFTVA------FIDTIGRFKIQLNGFFMMTVFMFAIAFPyNHWIKPENRIGFVVMYSLTFFFANF-- 418
Cdd:cd17315 213 GTASILASIIVGVVNLLAtlvairLVDKVGRRPLLLIGFAGMAASLLLLAIA-FLLPALAKAAGWLALLGILLYIAAFam 291
                       410       420
                ....*....|....*....|..
gi 8843890  419 GPNATTFIVPAEIFPARLRSTC 440
Cdd:cd17315 292 GAGPVPWLLLSEIFPLRIRGKG 313
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
72-439 7.62e-10

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 61.12  E-value: 7.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   72 AVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFgneakgvMTTLC----FFRFWLGFGIGGDYPL 147
Cdd:cd17357  53 LIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSK-------SAKSPelliFGRFLVGIACGLSTGF 125
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  148 SATIMSEYANKKTRGAFiaAVFAMQGV--GILAGGFVALAvssifdkkfpaptyavnRALSTPpqvdYIWRIIVMFGALP 225
Cdd:cd17357 126 VPMYLQEISPSELRGAL--GSLTQIGVtlGILLGQVFGLP-----------------SVLGTE----TLWPYLLFFPGIP 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  226 AALTYYWRMKMPETARYTALVAKNIKQA----------TADMSKVLQtDIELEERVEDDVKDPRQnyglfsKEFLRRHGL 295
Cdd:cd17357 183 ALLQLAALPFFPESPKFLLISKGDEEEAekslkflrgiEDDVDQELE-EIKKESEQMGDQKQVSL------MQLLRDPSL 255
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  296 HLLGTTSTWFLLDIAF---YSQNLFQKDIFSAIGWIPKAAtmnathevfRIARAQTLIA-LCSTVPGYWFtvafIDTIGR 371
Cdd:cd17357 256 RLPLLLVLVVSASQQFsgiNAIFFYSTFIFENAGFSPQLA---------EWANLGIGIVnVLSTIVGPFL----IEKVGR 322
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8843890  372 FKIQLNGFFMMTVFMFAIA-----FPYNHWIKpENRIGFVVMYslTFFFAnFGPNATTFIVPAEIFPARLRST 439
Cdd:cd17357 323 RPLLLISLSVCAVALLLMSvflflSEQNSWMS-YGCIVAIFLF--IFFFA-IGLGPIPWFIGAELFPQAPRSA 391
xylE PRK10077
D-xylose transporter XylE; Provisional
15-515 1.09e-09

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 60.48  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    15 AKTQLYHFTAIVIAGMGFFTDAYDLFCVSLVTKLLgRIYYFNPESakpgsLPPHVAAAVNGV----ALCGTLSGQLFFGW 90
Cdd:PRK10077   4 QYNSSYIFSITLVATLGGLLFGYDTAVISGTVESL-NTVFVAPQN-----LSESAANSLLGFcvasALIGCIIGGALGGY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    91 LGDKLGRKKVYGLTLIMMILCSVASG------LSFGNEAKGVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAF 164
Cdd:PRK10077  78 CSNRFGRRDSLKIAAVLFFISALGSAwpefgfTSIGPDNTGYVPEFVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   165 IA-AVFAmqgvgILAGGFVALAVSsifdkkfpaptYAVNRALSTPPQVDYIWRIIVMFGALPAALTYYWRMKMPETARYT 243
Cdd:PRK10077 158 VSfNQFA-----IIFGQLVVYFVN-----------YFIARSGDASWLNTDGWRYMFASEAIPALLFLMLLYFVPETPRYL 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   244 ALVAKNiKQATADMSKVLQTdiELEERVEDDVKDprqnyglfSKEFLRRHGLHLLGTTSTWFLLDIAFysqNLFQKdiFS 323
Cdd:PRK10077 222 MSRGKQ-EQAEGILRKIMGN--TLATQALQEIKH--------SLDHGRKTGGKLLMFGVGVIVIGVML---SVFQQ--FV 285
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   324 AIGWIPKAATmnathEVFRIARAQTLIALCSTV----PGYWFTVAFI---DTIGRFKIQLNGFFMMTVFMFAIAFPYNHW 396
Cdd:PRK10077 286 GINVVLYYAP-----EIFKTLGASTDIALLQTIivgvINLTFTVLAImtvDKFGRKPLQIIGALGMAIGMFSLGTAFYTQ 360
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   397 IKPENRIGFVVMYSlTFFFANFGPnaTTFIVPAEIFPARLRSTchgisaAAGKAGAIIGAFGFL----YAAQNQDKAKVD 472
Cdd:PRK10077 361 APGIVALLSMLFYV-AAFAMSWGP--VCWVLLSEIFPNAIRGK------ALAIAVAAQWIANYFvswtFPMMDKNSWLVA 431
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....
gi 8843890   473 AgYPPGIgvknSLIVLGVLNFIGMLFTF-LVPEPKGKSLEELSG 515
Cdd:PRK10077 432 H-FHNGF----SYWIYGCMGVLAALFMWkFVPETKGKTLEEMEA 470
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
25-440 1.18e-09

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 60.47  E-value: 1.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   25 IVIAGMGFFTDAYDLFCVSLVTKLLGRIYYfnPESAKPGSLppHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLT 104
Cdd:cd17368   1 ILAATSGNALEFFDFGVYGFFAVYIGRLFF--PSGSEFASL--LLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLT 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  105 LIMMILCSVASGLSFGNEAKGVMTTL--CFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAGGFV 182
Cdd:cd17368  77 LAIMALGTLLIALAPTYATIGIAAPLlvLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALV 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  183 ALAVSSIFDKkfpaptyavnRALStppqvDYIWRIIVMFGALPAALTYYWRMKMPETarytalVAKNIKQATADMSKVLQ 262
Cdd:cd17368 157 GYLLSLTLTA----------EALA-----EWGWRIPFFIGLLIIPLGLWLRRSLEET------EAFLERKARPTRRELFA 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  263 TdieleerveddVKDPRQNyglfskeFLRRHGLHLLGTTSTWFLLdiafysqnlfqkdiFSAIGWIPKAATMNAthevfR 342
Cdd:cd17368 216 L-----------LANNRRI-------ILLGMLLVAGSTVTFYFTT--------------VYTPTYAKTVLGLSA-----R 258
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  343 IARAQTLIALCSTVPGYWFTVAFIDTIGRFKIQLngffMMTVFMFAIAFPYNHWIKPENRIG--FVVMYSLTFFFANFGP 420
Cdd:cd17368 259 DSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLL----VITLAALVTLYPVFAWLTAAPSFGrlLLVLLVLSFFFGMYGG 334
                       410       420
                ....*....|....*....|
gi 8843890  421 NATTFIVpaEIFPARLRSTC 440
Cdd:cd17368 335 AMVVALV--ELFPVRVRSTG 352
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
29-249 4.76e-09

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 58.65  E-value: 4.76e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   29 GMGFFTDAYDLFCVSLVTkllgriyyfnPESAKPGSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVygLTLIMM 108
Cdd:cd17363   5 GLALMADGVEVFVVGFVL----------PSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQC--LLIALS 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  109 ILCSVASGLSFgneAKGVMTTLcFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIA--AVFAMQGvGILAGgfvALAV 186
Cdd:cd17363  73 VNGVFAFLSSF---VQGYGFFL-FCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSwlCMFWMIG-GLYAS---AMAW 144
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8843890  187 SSIfdkkfpaPTYAVNRALSTPPQVdYIWRIIVMFGALPAALTYYWRMKMPETARYTALVAKN 249
Cdd:cd17363 145 AII-------PHYGWGFSMGTAYQF-HSWRVFVIVCALPSVASVVALTFMPESPRFLLEVGKH 199
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
83-182 1.58e-08

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 56.42  E-value: 1.58e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   83 SGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRG 162
Cdd:cd17502  45 AFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPN------MTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERG 118
                        90       100
                ....*....|....*....|
gi 8843890  163 AFIAAVFAMQGVGILAGGFV 182
Cdd:cd17502 119 KYQGYIGAVFGIASVAGPLI 138
MFS_ProP cd17366
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ...
84-189 2.82e-08

Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340924 [Multi-domain]  Cd Length: 377  Bit Score: 55.83  E-value: 2.82e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   84 GQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGNEAKGVMT--TLCFFRFWLGFGIGGDYPLSATIMSEYANKKTR 161
Cdd:cd17366  56 GGLVFGPLGDKYGRQKVLAITIILMAASTFCIGLLPTYATIGVWApiLLLLARMVQGFSTGGEYGGAATFVAEYAPDRKR 135
                        90       100
                ....*....|....*....|....*....
gi 8843890  162 GaFIAAVFAMQGV-GILAGGFVALAVSSI 189
Cdd:cd17366 136 G-FLGSWLEFGTLaGFILGAGLVTLLTLL 163
PRK10406 PRK10406
alpha-ketoglutarate transporter; Provisional
84-240 3.22e-08

alpha-ketoglutarate transporter; Provisional


Pssm-ID: 182433 [Multi-domain]  Cd Length: 432  Bit Score: 55.97  E-value: 3.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    84 GQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGNEAKGVMTT--LCFFRFWLGFGIGGDYPLSATIMSEYANKKTR 161
Cdd:PRK10406  79 GGWLFGRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPalLLLARLFQGLSVGGEYGTSATYMSEVAVEGRK 158
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 8843890   162 GaFIAavfAMQGVGILAGGFVALAVSSIfdkkfpaptyaVNRALSTPPQVDYIWRIIVMFGALPAALTYYWRMKMPETA 240
Cdd:PRK10406 159 G-FYA---SFQYVTLIGGQLLALLVVVV-----------LQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDETS 222
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
26-249 3.43e-08

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 56.08  E-value: 3.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   26 VIAGMGFFTDAYDLFCVSLVTkllgriyyfnPESAKPGSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTL 105
Cdd:cd17438   2 FVLGLALMADGVEVFVVGFVL----------PSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISL 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  106 IMMILCSVASGLSFGNEAkgvmttLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIA--AVFAMQGvGILAGgfvA 183
Cdd:cd17438  72 AINASFAFLSSFVQGYGA------FLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSwlCMFWMIG-GLYAS---A 141
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 8843890  184 LAVSSIfdkkfpaPTYAVNRALSTPPQVdYIWRIIVMFGALPAALTYYWRMKMPETARYTALVAKN 249
Cdd:cd17438 142 MAWSII-------PHYGWGFSMGTNYHF-HSWRVFVIICALPCIASIIALKFMPESPRFLLEMGKH 199
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
65-201 8.43e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 54.14  E-value: 8.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   65 LPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGNEAkgvmTTLCFFRFWLGFGIGGD 144
Cdd:cd17316 210 LSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSP----TLLLLLLFILSFFVGGV 285
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 8843890  145 YPLSATIMSEYANKKTRGAFIAAVFAMqgvGILAGGFVALAVSSIFDKKFPAPTYAV 201
Cdd:cd17316 286 WGALYAYLAELFPTEVRATGVGLSYNL---GRLGGGGAPPLIALLLASTGGTGVPAL 339
PRK09952 PRK09952
shikimate transporter; Provisional
31-248 9.11e-08

shikimate transporter; Provisional


Pssm-ID: 182163 [Multi-domain]  Cd Length: 438  Bit Score: 54.35  E-value: 9.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    31 GFFTDAYDLFCVSLVTKLLGRIYYFNPESAKPGSLpphVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMIL 110
Cdd:PRK09952  30 GAVVDWYDFLLYGITAALVFNREFFPQVSPAMGTL---AAFATFGVGFLFRPLGGVVFGHFGDRLGRKRMLMLTVWMMGI 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   111 CSVASGL--SFGNEAKGVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGVG-ILAGGFVALAVS 187
Cdd:PRK09952 107 ATALIGLlpSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGlLLSTGLVSLISM 186
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 8843890   188 SIFDKKFpaptyavnralstppqVDYIWRIIVMFGALPAALTYYWRMKMPETARYTALVAK 248
Cdd:PRK09952 187 MTTDEQF----------------LSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHE 231
PRK03893 PRK03893
putative sialic acid transporter; Provisional
24-261 1.23e-07

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 54.32  E-value: 1.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    24 AIVIAGMGFFTDAYDLFCVSLVTkllgriyyfnPESAKPGSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGL 103
Cdd:PRK03893  21 AFSAAWLGYLLDGFDFVLITLVL----------TEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   104 TLIMMILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAfiAAVFAMQGVGIlaGGFVA 183
Cdd:PRK03893  91 SIVLFSVGTLACGFAPG------YWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNK--ASGFLISGFSI--GAVVA 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 8843890   184 LAVSSIFdkkfpAPTYAvnralstppqvdyiWRIIVMFGALPAALTYYWRMKMPETARYTALVAKniKQATADMSKVL 261
Cdd:PRK03893 161 AQVYSLV-----VPVWG--------------WRALFFIGILPIIFALWLRKNLPEAEDWKEKHAG--KAPVRTMVDIL 217
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
65-176 1.55e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 53.44  E-value: 1.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   65 LPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGD 144
Cdd:COG2814 240 LSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS------LWLLLLALFLLGFGFGLL 313
                        90       100       110
                ....*....|....*....|....*....|..
gi 8843890  145 YPLSATIMSEYANKKTRGAFIAAVFAMQGVGI 176
Cdd:COG2814 314 FPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
20-190 1.69e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 53.35  E-value: 1.69e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   20 YHFTAIVIAGMGFFTDAYDLFCVSLVTKLLGRIYYFNPESAkpgSLPphVAAAVngvaLCGTLsGQLFFGWLGDKLGRKK 99
Cdd:COG2223   2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQL---GLL--FAIPV----LVGAL-LRIPLGFLVDRFGPRR 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  100 VYGLTLIMMILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAG 179
Cdd:COG2223  72 VLLIGLLLLGIGLLLLALAVS------YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVA 145
                       170
                ....*....|.
gi 8843890  180 GFVALAVSSIF 190
Cdd:COG2223 146 AFLAPLLIAAF 156
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
84-190 1.97e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 53.32  E-value: 1.97e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   84 GQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGA 163
Cdd:cd17324  50 GALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS------FALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGR 123
                        90       100
                ....*....|....*....|....*..
gi 8843890  164 FIAAVFAMQGVGILAGGFVALAVSSIF 190
Cdd:cd17324 124 AIGLVFSGLTLGLVLGRPLGGLLGQLL 150
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
27-249 2.28e-07

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 53.38  E-value: 2.28e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   27 IAGMGFFTDAYDLFCVSLVTkllgriyyfnPESAKPGSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYgltLI 106
Cdd:cd17440   3 VLGMALMADGVEVFVVGFVL----------PSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSL---LI 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  107 MMILCSVASGLSFGNEAKGVmttLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIA--AVFAMQGvGILAGgfvAL 184
Cdd:cd17440  70 CMSVNGFFAFLSSFVQGYGL---FLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSwlCMFWMIG-GIYAS---AM 142
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 8843890  185 AVSSIfdkkfpaPTYAVNRALSTPPQVdYIWRIIVMFGALPAALTYYWRMKMPETARYTALVAKN 249
Cdd:cd17440 143 AWAII-------PHYGWSFSMGSAYQF-HSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKH 199
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
80-190 2.94e-07

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 52.58  E-value: 2.94e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   80 GTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSfgneakGVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKK 159
Cdd:cd17317  37 GVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFS------PSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPK 110
                        90       100       110
                ....*....|....*....|....*....|.
gi 8843890  160 TRgAFIAAVFAMqgvgILAGGFVALAVSSIF 190
Cdd:cd17317 111 YR-SFVGILFGL----FWALGYMLLALLAYL 136
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
65-228 4.89e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 52.21  E-value: 4.89e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   65 LPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLsFGNEAKGVMTTLCFFrfwLGFGIGGD 144
Cdd:COG2211 261 LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFF-LGPGNLWLLLVLAAL---AGIGLGAI 336
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  145 YPLSATIMS---EYANKKT----RGAFIAAVFAMQGVGILAGGFVALAVSSIFDkkfpaptYAVNRALSTppqvDYIWRI 217
Cdd:COG2211 337 LVLPWAMLAdvvDYDEWKTgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALFG-------YVAGAAQSP----SALTGI 405
                       170
                ....*....|.
gi 8843890  218 IVMFGALPAAL 228
Cdd:COG2211 406 RLLFFLLPAVL 416
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
27-242 6.47e-07

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 51.95  E-value: 6.47e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   27 IAGMGFFTDAYDLFCVSLVTkllgriyyfnPESAKPGSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVygltli 106
Cdd:cd17439   3 VLGLALMADGVEVFVVGFVL----------PSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQC------ 66
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  107 MMILCSVASGLSFGNEAKGVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIA--AVFAMQGvGILAGgfvAL 184
Cdd:cd17439  67 LLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSwlCMFWMIG-GIYAS---AM 142
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 8843890  185 AVSSIfdkkfpaPTYAVNRALSTPPQVdYIWRIIVMFGALPAALTYYWRMKMPETARY 242
Cdd:cd17439 143 AWAII-------PHYGWSFQMGSAYQF-HSWRVFVLVCAFPSVFAIGALTTMPESPRF 192
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
65-191 1.97e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.87  E-value: 1.97e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   65 LPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGNEAKGVMTTLCFFrfwlGFGIGGD 144
Cdd:COG2271 213 LSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLA----GFGLGGA 288
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 8843890  145 YPLSATIMSEYANKKTRGAFIAAVFAMqgvGILAGGFVALAVSSIFD 191
Cdd:COG2271 289 FGLLWALAAELFPKKARGTASGLVNTF---GFLGGALGPLLVGYLLD 332
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
66-191 3.14e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 49.49  E-value: 3.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   66 PPHVAAAVNGVALCGTLsGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGNeakGVMTTLCFFRFWLGFGIGgdY 145
Cdd:COG2223 240 AATAGLLAALFALLGAL-GRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGS---LWLFLVLFLLLGLALGGG--N 313
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 8843890  146 PLSATIMSEYANKKTRGAFIAAVFAMQGVGilaGGFVALAVSSIFD 191
Cdd:COG2223 314 GAVFALVPDIFPTKNAGAVYGLVGAAGGLG---GFLGPLLFGALLD 356
MFS_1 pfam07690
Major Facilitator Superfamily;
70-179 5.98e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.57  E-value: 5.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890     70 AAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGNEAKGVMTTLCFFrfwLGFGIGGDYPLSA 149
Cdd:pfam07690 237 AGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLL---LGFGFGLVFPALN 313
                          90       100       110
                  ....*....|....*....|....*....|
gi 8843890    150 TIMSEYANKKTRGAFIAAVFAMQGVGILAG 179
Cdd:pfam07690 314 ALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
67-230 6.41e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 48.36  E-value: 6.41e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   67 PHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGDYP 146
Cdd:cd17489  30 EAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS------VALLLVLRLIHGIGWGAFTT 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  147 LSATIMSEYANKKTR---------------------GAFIAAVFAMQGVGILAGGFVALAVSSIFDKKFPAPTYAVNRAL 205
Cdd:cd17489 104 AAATLVADIIPPSRRgegigyyglattlamalgpalGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEA 183
                       170       180
                ....*....|....*....|....*..
gi 8843890  206 STPPQVDYIWR--IIVMFGALPAALTY 230
Cdd:cd17489 184 GTRAFRRLVEKkvLPPALILFLASIAY 210
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
26-242 1.16e-05

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 47.50  E-value: 1.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   26 VIAGMGFFTDAYDLFCVSLVTkllgriyyfnPESAKPGSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTL 105
Cdd:cd17441   2 ILTGLAWMADAMEMMILSILA----------PQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISV 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  106 IMMILCSVASGLSfgneakGVMTTLCFFRFWLGFGIGGdYPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAGGFVALA 185
Cdd:cd17441  72 LWTLYYGILSAFA------PIYSWILVLRGLVGFGIGG-VPQSVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVF 144
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 8843890  186 VssifdkkfpAPTYAvnralstppqvdyiWRIIVMFGALPAALTYYWRMKMPETARY 242
Cdd:cd17441 145 V---------MPTLG--------------WRWLLILSALPLLIFAVLCFWLPESARY 178
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
65-190 3.38e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 46.01  E-value: 3.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   65 LPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVAsgLSFGNEAKGVMTTLCFFrfwLGFGIGGD 144
Cdd:cd17477 220 LSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALL--LPLVPGLPLALLVLLFL---WGGAAGPL 294
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 8843890  145 YPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAGGFVALAVSSIF 190
Cdd:cd17477 295 YTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAF 340
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
69-183 3.69e-05

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 46.03  E-value: 3.69e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   69 VAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSfgneakGVMTTLCFFRFWLGFGIGGDYPLS 148
Cdd:cd17323  35 VANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALA------PNIAMLIILRFLQGFFGSSPLAIG 108
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 8843890  149 ATIMSEYANKKTRG----AFIAAVFAMQGVGILAGGFVA 183
Cdd:cd17323 109 AGTIADLFTPEERGkamgVYSLGPLLGPALGPIIGGFIT 147
PRK12307 PRK12307
MFS transporter;
70-242 4.98e-05

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 45.69  E-value: 4.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    70 AAAVNGVALCGTLSGQLFFGWLGDKLGRKKvygLTLIMMILCSVASGLSfGNEAKGVMTTLCffRFWLGFGIGGDYPLSA 149
Cdd:PRK12307  55 GAFLATAAFIGRPFGGALFGLLADKFGRKP---LMMWSIVAYSVGTGLS-GLASGVIMLTLS--RFIVGMGMAGEYACAS 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   150 TIMSEYANKKTRGAfiAAVFAMQGVGIlaGGFVALAVSSIFDKKfpaptyavnralstppqvdYIWRIIVMFGALPAALT 229
Cdd:PRK12307 129 TYAVESWPKHLKSK--ASAFLVSGFGI--GNIIAAYFMPSFAEA-------------------YGWRAAFFVGLLPVLLV 185
                        170
                 ....*....|...
gi 8843890   230 YYWRMKMPETARY 242
Cdd:PRK12307 186 IYIRARAPESKEW 198
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
80-195 9.41e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 44.87  E-value: 9.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   80 GTLSGQLFFGWLGDKLGRKKvygLTLIMMILCSVASGL-SFGNEAkgvmTTLCFFRFWLGFGIGGDYPLSATIMSEYANK 158
Cdd:cd17325  43 AQLLFSPPAGRLSDRFGRKR---LLLLGLLLLAVSTLLfAFATSY----WQLLLARFLQGLASAAVWPAAMALIADIAPP 115
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 8843890  159 KTRGAFIAAVFAMQGVGILAGGFVALAVSSIFDKKFP 195
Cdd:cd17325 116 EERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAP 152
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
57-190 1.20e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 44.49  E-value: 1.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   57 PESAKPGSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGneakgvMTTLCFFRFW 136
Cdd:cd17320  23 PAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASS------IEQLLIARFL 96
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  137 LGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGV----GILAGGFVALAVS--SIF 190
Cdd:cd17320  97 QGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIapalAPLLGGLLLLFFGwrAIF 156
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
86-183 1.24e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 44.49  E-value: 1.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   86 LFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSfgneakGVMTTLCFFRFWLGFGiGGDYPLSATIMSEY-ANKKTRGA- 163
Cdd:cd17504  49 PILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA------PNLPVLIAGRALQGIG-GAVFPLAFALVREEfPPERVPVAq 121
                        90       100
                ....*....|....*....|..
gi 8843890  164 -FIAAVFAM-QGVGILAGGFVA 183
Cdd:cd17504 122 gILSATFGIgAGIGLPLGGWIV 143
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
86-191 1.93e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 43.70  E-value: 1.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   86 LFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFI 165
Cdd:cd17321  49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS------LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRAL 122
                        90       100
                ....*....|....*....|....*.
gi 8843890  166 AAVFAMQGVGILAGGFVALAVSSIFD 191
Cdd:cd17321 123 GLWGAVVGIGAALGPLLGGLLLELFG 148
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
69-183 1.97e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 43.75  E-value: 1.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   69 VAAAVNGVALCG--TLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVAsgLSFGNEAKGVMTTLCFFrfwLGFGIGGDYP 146
Cdd:cd17353 248 AGIAALAVSILSifNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFL--LPFIGSVAVLFVLGVAL---IGFCYGGGFA 322
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 8843890  147 LSATIMSEYANKKTRGAFIAAVFAMQGVGILAGGFVA 183
Cdd:cd17353 323 LFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIA 359
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
73-513 2.07e-04

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 43.88  E-value: 2.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   73 VNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGDYPLSATIM 152
Cdd:cd17362  44 VVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPS------YPVLLVGRLIYGVGIGLAMHAAPVYI 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  153 SEYANKKTRGAFIAAVFAMQGVGILAGgfvalavssifdkkfpaptYAVNRALSTppqVDYIWRIIVMFGALPA---ALT 229
Cdd:cd17362 118 AETSPSHIRGLLVSLKELFIVLGILLG-------------------YVSGYAFAD---VVGGWRYMYGLAAPPAlllGIG 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  230 YYWrmkMPETARYTALVAKNIKQATADMskvlqtdieleerveddvkdprqnygLFSkeflrrhglHLLGTTStwflldI 309
Cdd:cd17362 176 MWF---LPPSPRWQGNYRKPLIIGLGLV--------------------------LFQ---------QITGQPS------V 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  310 AFYSQNlfqkdIFSAIGWIPKAATMNATHEVFRIARAQTLIAlcstvpgywftVAFIDTIGRFKIQLNGFFMMTVFMFAI 389
Cdd:cd17362 212 LYYAAT-----IFKSAGFSAASDATLVSVGLGVFKLLMTIVA-----------VLLVDKLGRRPLLLGGVSGMVVSLFLL 275
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  390 AFPYNHWIKPENRIGFVVMYSLTFFFA----NFGPnaTTFIVPAEIFPARLRStchgisaaagkagaiiGAFGFLYAAQN 465
Cdd:cd17362 276 AAYNLFVQMGPAGLAWLSLVALLLYVGayqiSFGP--ISWLMVSEIFPLRVRG----------------RAIALAVLVNF 337
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|..
gi 8843890  466 QDKAKVDAGYPP---GIGVKNSLIVLGVLNFIGMLFTFL-VPEPKGKSLEEL 513
Cdd:cd17362 338 GSNALVSLAFLPlqeLIGLPGTFLGFGVIGVLALLFIYFtVPETKGLSLEEI 389
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
26-177 2.16e-04

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 43.68  E-value: 2.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   26 VIAGMGFFTDAYDLFCVSLVTkllgriyyfnPESAKPGSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTL 105
Cdd:cd17372   2 AYAGMGWVAEAMEMMLLSFVG----------PAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISA 71
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 8843890  106 IMMILCSVASGLSfgneakGVMTTLCFFRFWLGFGIGGdYPLSATIMSEYANKKTRGAFIAAVFAMQGVGIL 177
Cdd:cd17372  72 LWTFYAGFLSAFA------PNYMWLIILRCLVGLGLGG-GPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTI 136
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
80-187 2.76e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 43.41  E-value: 2.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890    80 GTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGL--SFgneakgvmTTLCFFRFWLGFGIGGDYPLSATIMSEYAN 157
Cdd:PRK11551  62 GLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQawDF--------PSLLVARLLTGVGLGGALPNLIALTSEAVG 133
                         90       100       110
                 ....*....|....*....|....*....|
gi 8843890   158 KKTRGAFIAAVFAmqgvGILAGGFVALAVS 187
Cdd:PRK11551 134 PRLRGTAVSLMYC----GVPFGGALASVIG 159
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
81-513 3.15e-04

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 43.16  E-value: 3.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   81 TLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGNEakgvmtTLCFFRFWLGFGIGGDYPLSATIMSEYANKKT 160
Cdd:cd17437  45 SLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYP------VLMVGRFVAGIGVGFALMIAPVYTAEVAPASS 118
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  161 RGAFIAAVFAMQGVGILAGgfvalavssifdkkfpaptYAVNRALSTPPqVDYIWRIIVMFGALPAALTYYWRMKMPETA 240
Cdd:cd17437 119 RGFLTSFPEIFINIGILLG-------------------YVSNYAFSGLP-LHVGWRLMLGVGAVPSLFLAIGVLAMPESP 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  241 RYTALVaknikqatadmskvlqtdieleerveddvkdprqnyglfskeflRRHGLHLLGttstwflldIAFYSQN----- 315
Cdd:cd17437 179 RWTPAV--------------------------------------------RRMLIAALG---------IHFFQQAsgida 205
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  316 --LFQKDIFSAIGWIPKAATMNAThevfriaraqtlIALCSTVPGYWFTVAF-IDTIGRFKIQLNGFFMMTVFMFAIAFP 392
Cdd:cd17437 206 vvLYSPRIFKKAGIKSKDKLLLAT------------VAVGVTKTLFILVATFlLDKVGRRPLLLTSTGGMTLSLTALATS 273
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  393 YNHWIKPENRIGFVVMYSLT-------FFFANFGPnaTTFIVPAEIFPARLRSTCHGISAAAGKAGAIIGAFGFLYAAQn 465
Cdd:cd17437 274 LTFIDRNGGGLTWALVLAITavcsfvaFFSIGAGP--ITWVYSSEIFPLRLRAQGASLGVVVNRLMSGTVSMTFLSMSK- 350
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*....
gi 8843890  466 qdkakvdagyppGIGVKNSLIVLGVLNFIGMLFT-FLVPEPKGKSLEEL 513
Cdd:cd17437 351 ------------AITTGGTFFLFAGVAAAAWVFFyFFLPETKGKSLEEI 387
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
80-432 3.48e-04

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 42.99  E-value: 3.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   80 GTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSfgnEAKGVMTTLCFFRFWLGF--GIGgdypLSATIM--SEY 155
Cdd:cd17432  62 GGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLS---KIAKSFEMIIVGRFLVGInaGIS----LNVVPMylGES 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  156 ANKKTRGAfiaavfamqgVGILAGGFVALAVssifdkkFPAPTYAVNRALSTPPQvdyiWRIIVMFGALPAALTYYWRMK 235
Cdd:cd17432 135 APKNLRGA----------VGLVPAIFITLGI-------LLGQVLGLRELLGNEEG----WPLLLALTGVPALLQLLTLPF 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  236 MPETARYTALVAKNIKQA---------TADMSKVLQtDIELEERVEDDVKdPRQNYGLFSKEFLRRH---------GLHL 297
Cdd:cd17432 194 FPESPRYLLIEKGDEEAArkalqrlrgKEDVDDEME-EMLEEQRAEKGVG-TVSVLELFRDRSVRWQlisiivlmaGQQL 271
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  298 LGTTSTWFLLDiafysqnlfqkDIFSAIGwIPKAATMNAThevFRIARAQTLIALCSTVpgywftvaFIDTIGRFKIQLN 377
Cdd:cd17432 272 CGINAIYFYAD-----------SIFLEAG-IPEDKIQYVT---VGTGACEVLATITCVL--------VIERLGRRPLLIG 328
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 8843890  378 GFFMMT----VFMFAIAFpynhwikpENRIGFVVMYSLTFFFA-----NFGPNATTFIVPAEIF 432
Cdd:cd17432 329 GFGLMAvwcaVLTVALSL--------QNTVSWMPYLSIVCIFAyiasfGIGPAGVPFILTTEIF 384
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
69-242 4.02e-04

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 42.64  E-value: 4.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   69 VAAAVNGVALcgtlsGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGDYPLS 148
Cdd:cd17360  41 VSSTVAGAAV-----GAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPN------KEVLIVGRVLVGLGVGIASMTV 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  149 ATIMSEYANKKTRGAFIAAvfamQGVGILAGGFVAlavssifdkkfpaptYAVNRALStppQVDYIWRIIVMFGALPAAL 228
Cdd:cd17360 110 PLYIAEAAPPRIRGRLVTI----NVLFITGGQFVA---------------YVINGAFS---YLPGGWRWMLGLAAVPAVL 167
                       170
                ....*....|....
gi 8843890  229 TYYWRMKMPETARY 242
Cdd:cd17360 168 QFIGLLFLPESPRW 181
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
80-189 4.56e-04

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 42.81  E-value: 4.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890     80 GTLSGQLFFGWLGDKLGRKKVYGltlIMMILCSVASGLSFgNEAKGVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKK 159
Cdd:TIGR00894  88 GQIIIQIPVGYLAGKYVFKWSIG---IGMFLSSVISIVIP-WAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPK 163
                          90       100       110
                  ....*....|....*....|....*....|
gi 8843890    160 TRGAFIAAVFAmqgvGILAGGFVALAVSSI 189
Cdd:TIGR00894 164 ERSRLLGMSTS----GFQLGTFIFLPISGW 189
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
63-190 4.80e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 42.56  E-value: 4.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   63 GSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSfgneakGVMTTLCFFRFWLGFGIG 142
Cdd:cd17325 230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA------TSFWLLLLLLALLGLGLG 303
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 8843890  143 GDYPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAGGFVALAVSSIF 190
Cdd:cd17325 304 LVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF 351
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
86-183 6.24e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 42.18  E-value: 6.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   86 LFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFI 165
Cdd:cd17473  53 PLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDS------LYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKML 126
                        90       100
                ....*....|....*....|..
gi 8843890  166 AAVFAMQGVG----ILAGGFVA 183
Cdd:cd17473 127 GLQSAAMSLGgvvfLLLGGALA 148
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
65-191 8.73e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 41.78  E-value: 8.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   65 LPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVAsGLSFGNEAKGVMTTLCffrfwLGFGIGGD 144
Cdd:COG2807 247 LSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLL-GLLLAPGSLPWLWAVL-----LGLGQGGL 320
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 8843890  145 YPLSATIMSEYAnkkTRGAFIAAVFAM-QGVGILAGGFVALAVSSIFD 191
Cdd:COG2807 321 FPLALTLIGLRA---RTPAEAAALSGMaQSVGYLLAALGPLLVGALHD 365
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
78-145 9.63e-04

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 41.30  E-value: 9.63e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 8843890   78 LCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVasGLSFGNEAKGVMTtlcfFRFWLGFGIGGDY 145
Cdd:cd17445  46 ILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGV--LVAVAASPSLFMA----MRFLLGAALAGVY 107
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
321-513 1.00e-03

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 41.33  E-value: 1.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  321 IFSAIGWIPKAATMNATHEVFRIARAQTLIALCstvpgywftvaFIDTIGRFKIQLNGFFMMTVFMFAIAFpynhWIKPE 400
Cdd:cd17436 218 IFRSVGFQSNSSAVLASVGLGVVKVIATLLAML-----------FADRAGRRSLLIAGCSVMAVSVSGIGL----WITLL 282
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  401 NRIGFVVMYSLtfffaNFGPnaTTFIVPAEIFPARLRSTCHGISAAAGKAGAIIGAFGFLyaaqnqdkAKVDAgyppgIG 480
Cdd:cd17436 283 CLMAFVSAFSI-----GFGP--MTWLVLSEIYPADIRGRAFSFCNSFNWAANLLITLSFL--------DLIDV-----IG 342
                       170       180       190
                ....*....|....*....|....*....|....
gi 8843890  481 VKNSLIVLGVLNFIGMLFTFL-VPEPKGKSLEEL 513
Cdd:cd17436 343 LSWTFLLYGVVGVAGVVFIYLfVPETKGQSLEEI 376
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
65-179 1.02e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 41.45  E-value: 1.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   65 LPPHVAAAVNGVALCGTLSGQLFFGWLGDKLG---RKKVYGLTLIMMILCSVASGLSFGNEAKGVMTTLCFfrfWLGFGI 141
Cdd:cd17475 231 LSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggrRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLI---LLGLFA 307
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 8843890  142 GGDYPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAG 179
Cdd:cd17475 308 IGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIG 345
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
134-438 1.45e-03

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 41.08  E-value: 1.45e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  134 RFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAGGFVALAVSSIfdkkfpaptyavnralstppqVDY 213
Cdd:cd17361 111 RILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILIANLINYGTSKI---------------------KPN 169
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  214 IWRIIVMFGALPAALTYYWRMKMPETARYTALVaknikqatadMSKVLQTdieleerveddvkdprqnyglFSKeflrrh 293
Cdd:cd17361 170 GWRLSLGLAAVPALILLLGSLFLPETPNSPQLV----------IAILIPF---------------------FQQ------ 212
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  294 glhLLGTTStwflldIAFYSQNLFQkdifsAIGWIPKAATMNAThevfriaraqtlIALCSTVPGYWFTVAFIDTIGRFK 373
Cdd:cd17361 213 ---LTGINV------IMFYAPVLFQ-----TLGFGSDASLISAV------------ITGAVNVVSTLVSIYLVDRFGRRF 266
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 8843890  374 IQLNGFFMMTVFMFAIA------FPYNHWIKPENRIGFVVM---YSLTFFFAnFGPnaTTFIVPAEIFPARLRS 438
Cdd:cd17361 267 LLLEGGVQMLASQVAIGillavkFGDGGELPKAYAIAVVVLiclYVAAFAWS-WGP--LGWLVPSEIFPLETRS 337
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
85-181 1.84e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 40.63  E-value: 1.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   85 QLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSFGneakgvMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTR--- 161
Cdd:cd17319  55 QVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATS------LTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERgra 128
                        90       100
                ....*....|....*....|....*.
gi 8843890  162 ------GAFIAAVFAMQGVGILAGGF 181
Cdd:cd17319 129 tglfnsGAPLGAAIGPPLSGWLLLLF 154
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
87-188 2.17e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 40.30  E-value: 2.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   87 FFGWLGDKLGRKKVYGLTL----IMMILCSVASglSFGneakgvmtTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRG 162
Cdd:cd17328  53 IFGYLGDRYNRKWILAVGIliwsAATLLSSFAP--NFW--------QLLLFRALVGIGEASYSPIAPTIIADLFPKEKRT 122
                        90       100       110
                ....*....|....*....|....*....|.
gi 8843890  163 AFIaAVFAM-----QGVGILAGGFVALAVSS 188
Cdd:cd17328 123 RAL-GVFYFaiplgSGLGYVVGGLVAQATGG 152
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
82-180 2.30e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 40.23  E-value: 2.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   82 LSGQLFFGWLGDK--LGRKKVYGLTLIMMILCSVASGLSFGNeakgvmTTLCFFRFWLGFGIGGDYPLSATIMSEYANKK 159
Cdd:cd17352 232 IVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAFPLATTY------VGLIVFSVLFGFCSGSYSSLTPVILADLVGLE 305
                        90       100
                ....*....|....*....|.
gi 8843890  160 TRGAFIAAVFAMQGVGILAGG 180
Cdd:cd17352 306 KLSNAYGLVLLFQGLAALVGP 326
ClC_euk cd01036
Chloride channel, ClC. These domains are found in the eukaryotic halogen ion (Cl-, Br- and I-) ...
36-194 2.33e-03

Chloride channel, ClC. These domains are found in the eukaryotic halogen ion (Cl-, Br- and I-) channel proteins that perform a variety of functions including cell volume regulation, membrane potential stabilization, charge compensation necessary for the acidification of intracellular organelles, signal transduction and transepithelial transport. They are also involved in many pathophysiological processes and are responsible for a number of human diseases. These proteins belong to the ClC superfamily of chloride ion channels, which share the unique double-barreled architecture and voltage-dependent gating mechanism. The gating is conferred by the permeating anion itself, acting as the gating charge. Some proteins possess long C-terminal cytoplasmic regions containing two CBS (cystathionine beta synthase) domains of putative regulatory function.


Pssm-ID: 238507 [Multi-domain]  Cd Length: 416  Bit Score: 40.40  E-value: 2.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   36 AYDLFCVSLVTKLLGRIYYFNPESAkpGSLPPHVAAAVNGVALCGTLSGQLFFGwlgdklgrkKVYGLTlimmilCSVAS 115
Cdd:cd01036  39 MWVLWSVVLVLISSGICLYFAPQAA--GSGIPEVMAYLNGVHLPMYLSIRTLIA---------KTISCI------CAVAS 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890  116 GLSFGNEAKGVMTTLCFFRFwLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAmqgVGILA------GG--FVALAVS 187
Cdd:cd01036 102 GLPLGKEGPLVHLGAMIGAG-LLQGRSRTLGCHVHLFQLFRNPRDRRDFLVAGAA---AGVASafgapiGGllFVLEEVS 177

                ....*..
gi 8843890  188 SIFDKKF 194
Cdd:cd01036 178 TFFPVRL 184
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
89-171 3.01e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 39.87  E-value: 3.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   89 GWLGDKLGRKKVYGLTLIMMILCSVASGLSfgneakGVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAfIAAV 168
Cdd:cd17503  52 GWLADRFGTRRLFLTALALFTLGSLLCGLA------PNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGA-AMGL 124

                ...
gi 8843890  169 FAM 171
Cdd:cd17503 125 VGL 127
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
65-183 7.61e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 38.68  E-value: 7.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   65 LPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLsfgneAKGVMTTLCFFrFWLGFGIGGD 144
Cdd:COG0738 243 LSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALL-----APGPWLALIGL-ALVGLGLSLM 316
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 8843890  145 YPLSATIMSEYANKKTrGAFIAAVFAMQGVGILAG----GFVA 183
Cdd:COG0738 317 FPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGppliGFLA 358
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
85-185 9.48e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 38.32  E-value: 9.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8843890   85 QLFFGWLGDKLGRKKVYGLTLIMMILCSVASGLSfgneakGVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAF 164
Cdd:cd17474  51 MPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS------DSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKA 124
                        90       100
                ....*....|....*....|....*
gi 8843890  165 IAAVFAMQGVGI----LAGGFVALA 185
Cdd:cd17474 125 MGLYEAALGLGIavgpLLGGLLAAI 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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