disintegrin-like and metalloprotease with thrombospondin type 1 motif, 5, partial [Homo sapiens]
zinc metalloprotease; M10 family metallopeptidase domain-containing protein( domain architecture ID 10259619)
zinc metalloprotease may be a member of the astacin-like protease family or the adamalysin/reprolysin-like protease family| M10 family metallopeptidase domain-containing protein is a metalloendopeptidase similar to matrix metalloproteinases that may be endopeptidases that degrade various components of the extracellular matrix
List of domain hits
Name | Accession | Description | Interval | E-value | |||
ZnMc_ADAMTS_like | cd04273 | Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ... |
269-412 | 6.62e-78 | |||
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix. : Pssm-ID: 239801 Cd Length: 207 Bit Score: 239.83 E-value: 6.62e-78
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Pep_M12B_propep super family | cl03265 | Reprolysin family propeptide; This region is the propeptide for members of peptidase family ... |
66-178 | 6.68e-14 | |||
Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned. The actual alignment was detected with superfamily member pfam01562: Pssm-ID: 460254 Cd Length: 128 Bit Score: 68.11 E-value: 6.68e-14
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Name | Accession | Description | Interval | E-value | |||
ZnMc_ADAMTS_like | cd04273 | Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ... |
269-412 | 6.62e-78 | |||
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix. Pssm-ID: 239801 Cd Length: 207 Bit Score: 239.83 E-value: 6.62e-78
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Reprolysin | pfam01421 | Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ... |
269-412 | 7.37e-16 | |||
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes. Pssm-ID: 426256 [Multi-domain] Cd Length: 200 Bit Score: 75.80 E-value: 7.37e-16
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Pep_M12B_propep | pfam01562 | Reprolysin family propeptide; This region is the propeptide for members of peptidase family ... |
66-178 | 6.68e-14 | |||
Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned. Pssm-ID: 460254 Cd Length: 128 Bit Score: 68.11 E-value: 6.68e-14
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Name | Accession | Description | Interval | E-value | ||||
ZnMc_ADAMTS_like | cd04273 | Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ... |
269-412 | 6.62e-78 | ||||
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix. Pssm-ID: 239801 Cd Length: 207 Bit Score: 239.83 E-value: 6.62e-78
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ZnMc_ADAM_like | cd04267 | Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ... |
269-412 | 1.89e-23 | ||||
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. Pssm-ID: 239795 Cd Length: 192 Bit Score: 96.72 E-value: 1.89e-23
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ZnMc_adamalysin_II_like | cd04269 | Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ... |
269-412 | 1.22e-21 | ||||
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. Pssm-ID: 239797 [Multi-domain] Cd Length: 194 Bit Score: 91.91 E-value: 1.22e-21
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Reprolysin | pfam01421 | Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ... |
269-412 | 7.37e-16 | ||||
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes. Pssm-ID: 426256 [Multi-domain] Cd Length: 200 Bit Score: 75.80 E-value: 7.37e-16
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Pep_M12B_propep | pfam01562 | Reprolysin family propeptide; This region is the propeptide for members of peptidase family ... |
66-178 | 6.68e-14 | ||||
Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned. Pssm-ID: 460254 Cd Length: 128 Bit Score: 68.11 E-value: 6.68e-14
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ZnMc_salivary_gland_MPs | cd04272 | Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ... |
269-412 | 3.04e-06 | ||||
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods. Pssm-ID: 239800 Cd Length: 220 Bit Score: 47.73 E-value: 3.04e-06
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Reprolysin_5 | pfam13688 | Metallo-peptidase family M12; |
268-412 | 2.45e-05 | ||||
Metallo-peptidase family M12; Pssm-ID: 372673 Cd Length: 191 Bit Score: 44.72 E-value: 2.45e-05
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Blast search parameters | ||||
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