NCBI Conserved Domain Search

Conserved domains on [gi|6009737|dbj|BAA85043|]

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olfactory receptor protein ZF9A [Danio rerio]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

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List of domain hits

Name

Accession

Description

Interval

E-value

7tm_GPCRs super family

cl28897

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...

45-300

1.94e-61

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

The actual alignment was detected with superfamily member cd13954:

Pssm-ID: 475119 [Multi-domain] Cd Length: 270 Bit Score: 196.94 E-value: 1.94e-61

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd13954  14 TLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLGGTECFLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd13954  94 MAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLSCSDTSLNEL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVIstS 284
Cdd:cd13954 174 VIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSSYSSDLDKVV--S 251

                       250
                ....*....|....*..
gi 6009737  285 LAYAI-PPMLNPIIYVL 300
Cdd:cd13954 252 VFYTVvTPMLNPIIYSL 268

Name

Accession

Description

Interval

E-value

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

45-300

1.94e-61

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 196.94 E-value: 1.94e-61

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd13954  14 TLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLGGTECFLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd13954  94 MAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLSCSDTSLNEL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVIstS 284
Cdd:cd13954 174 VIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSSYSSDLDKVV--S 251

                       250
                ....*....|....*..
gi 6009737  285 LAYAI-PPMLNPIIYVL 300
Cdd:cd13954 252 VFYTVvTPMLNPIIYSL 268

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

46-313

3.93e-41

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 144.57 E-value: 3.93e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737     46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVVM 125
Cdd:pfam13853   9 FLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAM 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737    126 AYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKIM 205
Cdd:pfam13853  89 AVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKVNNIY 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737    206 GFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSllLFSTSNSRVISTSL 285
Cdd:pfam13853 169 GLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVH--RFGHNVPPLLQIMM 246

                         250       260       270
                  ....*....|....*....|....*....|.
gi 6009737    286 AYA---IPPMLNPIIYVLNTAEITNTIRKGF 313
Cdd:pfam13853 247 ANAylfFPPVLNPIVYSVKTKQIRDCVKRML 277

Name

Accession

Description

Interval

E-value

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

45-300

1.94e-61

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 196.94 E-value: 1.94e-61

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd13954  14 TLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLGGTECFLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd13954  94 MAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLSCSDTSLNEL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVIstS 284
Cdd:cd13954 174 VIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSSYSSDLDKVV--S 251

                       250
                ....*....|....*..
gi 6009737  285 LAYAI-PPMLNPIIYVL 300
Cdd:cd13954 252 VFYTVvTPMLNPIIYSL 268

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

46-309

1.26e-58

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 189.81 E-value: 1.26e-58

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVVM 125
Cdd:cd15223  15 LVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAMESSILLVM 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  126 AYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKIM 205
Cdd:cd15223  95 ALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACGDTTINSIY 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  206 GFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTS-NSRVISTS 284
Cdd:cd15223 175 GLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFGKTIPpDVHVLLSV 254

                       250       260
                ....*....|....*....|....*
gi 6009737  285 LAYAIPPMLNPIIYVLNTAEITNTI 309
Cdd:cd15223 255 LYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

45-305

4.22e-57

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 185.96 E-value: 4.22e-57

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15917  14 ALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAMESGVLLA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15917  94 MAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACGDTRVNSI 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNS-RVIST 283
Cdd:cd15917 174 YGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHVPPHvHILLA 253

                       250       260
                ....*....|....*....|..
gi 6009737  284 SLAYAIPPMLNPIIYVLNTAEI 305
Cdd:cd15917 254 NLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

45-305

8.33e-57

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 185.01 E-value: 8.33e-57

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15222  14 ALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMESSVLLA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15222  94 MAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACSDTRVNSI 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFftYLTSLLLFSTSNSRVISTS 284
Cdd:cd15222 174 YGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMI--GLSMVHRFGKHASPLVHVL 251

                       250       260
                ....*....|....*....|....
gi 6009737  285 LAYA---IPPMLNPIIYVLNTAEI 305
Cdd:cd15222 252 MANVyllVPPVLNPIIYSVKTKQI 275

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

45-300

6.31e-56

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 182.65 E-value: 6.31e-56

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15225  14 TLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTECFLLAA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15225  94 MAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACADTSLNEI 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVIstS 284
Cdd:cd15225 174 AIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYSPETDKLL--S 251

                       250
                ....*....|....*..
gi 6009737  285 LAYA-IPPMLNPIIYVL 300
Cdd:cd15225 252 LFYTvVTPMLNPIIYSL 268

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

45-300

1.25e-55

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 181.94 E-value: 1.25e-55

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15230  14 TLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFLLAA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15230  94 MAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCSDTHINEL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVISTS 284
Cdd:cd15230 174 VLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYSLDQDKVVSVF 253

                       250
                ....*....|....*.
gi 6009737  285 LAYAIpPMLNPIIYVL 300
Cdd:cd15230 254 YTVVI-PMLNPLIYSL 268

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

45-305

5.23e-55

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 180.50 E-value: 5.23e-55

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15235  15 TLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFLLAV 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15235  95 MAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDTSLNEL 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVIstS 284
Cdd:cd15235 175 LIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSSYSADKDRVA--T 252

                       250       260
                ....*....|....*....|..
gi 6009737  285 LAYA-IPPMLNPIIYVLNTAEI 305
Cdd:cd15235 253 VMYTvVTPMLNPFIYSLRNKDV 274

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

45-305

1.71e-52

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 173.99 E-value: 1.71e-52

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15953  14 TLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIMESAVLVA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15953  94 MAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACGDTTINRI 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSllLFSTS---NSRVI 281
Cdd:cd15953 174 YGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTH--RFGQGiapHIHII 251

                       250       260
                ....*....|....*....|....
gi 6009737  282 STSLAYAIPPMLNPIIYVLNTAEI 305
Cdd:cd15953 252 LANLYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

45-300

8.54e-52

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 172.03 E-value: 8.54e-52

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15918  14 TVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDNFLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15918  94 MAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCSDTHLNEL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVISTS 284
Cdd:cd15918 174 VILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHSASKDSVAAVM 253

                       250
                ....*....|....*.
gi 6009737  285 LAyAIPPMLNPIIYVL 300
Cdd:cd15918 254 YT-VVTPMLNPFIYSL 268

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

45-305

2.83e-51

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 170.64 E-value: 2.83e-51

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15952  14 ALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGMESAVLVA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINkI 204
Cdd:cd15952  94 MAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACASIRIN-I 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSllLFSTSNSRVISTS 284
Cdd:cd15952 173 IYGLFAISVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTH--RFGHNIPRYIHIL 250

                       250       260
                ....*....|....*....|....
gi 6009737  285 LA---YAIPPMLNPIIYVLNTAEI 305
Cdd:cd15952 251 LAnlyVVLPPMLNPVIYGVRTKQI 274

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

45-300

2.64e-50

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 168.02 E-value: 2.64e-50

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15227  14 ALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASELALLTV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15227  94 MAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKLSCSDTYLNEI 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVIstS 284
Cdd:cd15227 174 GVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSPSLLDLLL--S 251

                       250
                ....*....|....*..
gi 6009737  285 LAYAI-PPMLNPIIYVL 300
Cdd:cd15227 252 VFYSVvPPTLNPIIYSL 268

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

45-305

3.72e-50

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 167.77 E-value: 3.72e-50

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15229  14 TLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFLLSA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNN---TSMISIFSAVFMFNSIIvasMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNI 201
Cdd:cd15229  94 MAYDRYAAICHPLHYVQIMSKqvcVQLVGGAWALGFLYALI---NTLLLLNLHFCGPNEINHFSCELPSLLPLSCSDTFA 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  202 NKIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVI 281
Cdd:cd15229 171 NKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSASSSVLDRVF 250

                       250       260
                ....*....|....*....|....*
gi 6009737  282 stSLAYAI-PPMLNPIIYVLNTAEI 305
Cdd:cd15229 251 --SIQYSIlTPMLNPIIYSLKNKEV 273

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

45-300

5.03e-50

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 167.75 E-value: 5.03e-50

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15234  14 TVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDNFLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNntsmiSIFSAVFMFNSIIVASMVSLVTN-----ISFCKSNVIQSYLCDHGPMFRMACNDN 199
Cdd:cd15234  94 MAYDRYVAICHPLHYTVIMN-----PCLCGLLVLLSLLISILDSLLHSlmvlqLSFCTDVEIPHFFCELAQVLKLACSDT 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  200 NINKIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSR 279
Cdd:cd15234 169 LINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTHSSRKTA 248

                       250       260
                ....*....|....*....|..
gi 6009737  280 VisTSLAY-AIPPMLNPIIYVL 300
Cdd:cd15234 249 V--ASVMYtVVTPMLNPFIYSL 268

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

46-300

3.87e-49

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 165.12 E-value: 3.87e-49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVVM 125
Cdd:cd15232  15 LTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSELLLLTAM 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  126 AYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKIM 205
Cdd:cd15232  95 AYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCSDTSLNEIM 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  206 GFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVISTsL 285
Cdd:cd15232 175 AFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSYSPEKDKVVAV-L 253

                       250
                ....*....|....*
gi 6009737  286 AYAIPPMLNPIIYVL 300
Cdd:cd15232 254 YSVVTPTLNPLIYSL 268

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

45-300

3.94e-49

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 165.09 E-value: 3.94e-49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15431  14 TLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITECLLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIfsAVFMFNSIIVASMV-SLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINK 203
Cdd:cd15431  94 MAYDRFVAICNPLRYTLIMSWRVCIQL--AAGSWVSAFLLTVIpVLTMPLHFCGPNVINHFFCEVQALLKLACSDTSLNE 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  204 IMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVIST 283
Cdd:cd15431 172 ILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKSSSDQDKIISV 251

                       250
                ....*....|....*..
gi 6009737  284 SLAyAIPPMLNPIIYVL 300
Cdd:cd15431 252 FYG-VVTPMLNPLIYSL 267

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

45-311

4.73e-49

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 165.17 E-value: 4.73e-49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15419  14 TVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEGFLLAA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15419  94 MAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLSCSDTFINEL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVISTS 284
Cdd:cd15419 174 VMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAVSSPEQSKVVSVF 253

                       250       260
                ....*....|....*....|....*..
gi 6009737  285 LAYAIpPMLNPIIYVLNTAEITNTIRK 311
Cdd:cd15419 254 YTLVI-PMLNPLIYSLRNKDVKEALKR 279

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

46-305

9.58e-49

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 164.39 E-value: 9.58e-49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVVM 125
Cdd:cd15221  15 LLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVTESAILLAM 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  126 AYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKIM 205
Cdd:cd15221  95 AFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACADITVNIWY 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  206 GFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNS-RVISTS 284
Cdd:cd15221 175 GLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRFGRHIPRHvHILLAN 254

                       250       260
                ....*....|....*....|.
gi 6009737  285 LAYAIPPMLNPIIYVLNTAEI 305
Cdd:cd15221 255 LYVLVPPMLNPIVYGVKTKQI 275

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

45-311

9.75e-49

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 164.50 E-value: 9.75e-49

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15409  14 TLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECFLLAA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15409  94 MAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKISCTDPSINEL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVISTS 284
Cdd:cd15409 174 VLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYALDQDMMDSLF 253

                       250       260
                ....*....|....*....|....*..
gi 6009737  285 LAYAIpPMLNPIIYVLNTAEITNTIRK 311
Cdd:cd15409 254 YTIVI-PLLNPFIYSLRNKEVIDALRK 279

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

45-305

1.04e-48

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 164.36 E-value: 1.04e-48

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15231  14 TLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTECLLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFM---FNSIIVASMVSLVtniSFCKSNVIQSYLCDHGPMFRMACNDNNI 201
Cdd:cd15231  94 MAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLcgfLNSAVHTVLTFRL---SFCGSNQISHFFCDIPPLLKLSCSDTSL 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  202 NKIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVI 281
Cdd:cd15231 171 NEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGYSLDKDTLI 250

                       250       260
                ....*....|....*....|....
gi 6009737  282 STsLAYAIPPMLNPIIYVLNTAEI 305
Cdd:cd15231 251 SV-LYSIVTPMLNPIIYSLRNKEV 273

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

45-305

1.33e-48

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 163.74 E-value: 1.33e-48

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15950  14 ALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVESGVLLA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15950  94 MAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACADPRPSSL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTS-NSRVIST 283
Cdd:cd15950 174 YSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYTQRFGQGVPpHTQVLLA 253

                       250       260
                ....*....|....*....|..
gi 6009737  284 SLAYAIPPMLNPIIYVLNTAEI 305
Cdd:cd15950 254 DLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

20-313

6.94e-48

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 162.53 E-value: 6.94e-48

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   20 FFILGLSGIP-YSNLYYIFIFIIYFITVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQY 98
Cdd:cd15943   2 FILLGLTDNPeLQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   99 ISYNACLVNMFFVFLFSSMQSLTLVVMAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKS 178
Cdd:cd15943  82 ISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGS 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  179 NVIQSYLCDHGPMFRMACNDNNINKIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIY 258
Cdd:cd15943 162 NVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIF 241

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6009737  259 FLPIFFTYLTSLLLFSTSNSRVISTSLAYAIpPMLNPIIYVLNTAEITNTIRKGF 313
Cdd:cd15943 242 YGTTLFMYLRPSSSYSLDQDKVVSVFYTVVI-PMLNPLIYSLRNKEVKDALRRIL 295

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

45-300

7.42e-48

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 161.88 E-value: 7.42e-48

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15912  14 TLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTTEFFLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNN--TSMISIFSAVFMFNSIIVASMvsLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNIN 202
Cdd:cd15912  94 MSFDRYVAICNPLHYPTIMNSrvCLQLVLGSWVGGFLLILPPTI--LVFQLPFCGPNVINHFFCDSGPLLKLSCSDTRLI 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  203 KIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVIS 282
Cdd:cd15912 172 ELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQSSSLDLNKVVA 251

                       250
                ....*....|....*...
gi 6009737  283 TsLAYAIPPMLNPIIYVL 300
Cdd:cd15912 252 L-LNTVVTPLLNPFIYTL 268

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

20-311

6.26e-47

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 160.13 E-value: 6.26e-47

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   20 FFILGLSGIPYSNLYYIFIFIIY-FITVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQY 98
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIyGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   99 ISYNACLVNMFFVFLFSSMQSLTLVVMAYDRLIAICLPLRYHVIVnnTSMISIFSAVFMFNSIIVASMV--SLVTNISFC 176
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIM--SRKLCVLLVAGSYLWGIVCSLIhtCGLLRLSFC 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  177 KSNVIQSYLCDHGPMFRMACNDNNINKIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVG 256
Cdd:cd15410 159 GSNVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAIT 238

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6009737  257 IYFLPIFFTYLTSLLLFSTSNSRVISTSLAYAIpPMLNPIIYVLNTAEITNTIRK 311
Cdd:cd15410 239 IFHGTILFMYCRPSSSYSLDTDKVASVFYTVVI-PMLNPLIYSLRNKDVKDALRK 292

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

45-311

2.70e-46

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 158.30 E-value: 2.70e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15406  23 TVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVFAIAECYMLTA 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15406 103 MAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPLLKLSCSSTYINEL 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVISTS 284
Cdd:cd15406 183 LLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLKPSSSSSMTQEKVSSVF 262

                       250       260
                ....*....|....*....|....*..
gi 6009737  285 LAYAIpPMLNPIIYVLNTAEITNTIRK 311
Cdd:cd15406 263 YTTVI-PMLNPLIYSLRNKDVKNALKK 288

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

45-306

3.09e-46

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 157.71 E-value: 3.09e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15421  14 ALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGAECLLLAL 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNT---SMISIFSAVFMFNSIIVAsmvSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNI 201
Cdd:cd15421  94 MAYDRYVAICHPLRYPVLMSPRvclLMAAGSWLGGSLNSLIHT---VYTMHFPYCGSREIHHFFCEVPALLKLSCADTSA 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  202 NKIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVI 281
Cdd:cd15421 171 YETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYHSPEQDKVV 250

                       250       260
                ....*....|....*....|....*.
gi 6009737  282 stSLAYAI-PPMLNPIIYVLNTAEIT 306
Cdd:cd15421 251 --SVFYTIlTPMLNPLIYSLRNKEVL 274

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

45-311

4.21e-46

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 157.56 E-value: 4.21e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15412  14 TLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEYYMLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15412  94 MAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCSDTYVKET 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVISTS 284
Cdd:cd15412 174 AMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEESVEQSKIVAVF 253

                       250       260
                ....*....|....*....|....*..
gi 6009737  285 LAYAIpPMLNPIIYVLNTAEITNTIRK 311
Cdd:cd15412 254 YTFVS-PMLNPLIYSLRNKDVKQALKK 279

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

45-311

7.66e-46

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 156.71 E-value: 7.66e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15411  14 TVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECFLLGL 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNT---SMISIFSAVFMFNSIIvasMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNI 201
Cdd:cd15411  94 MAYDRYVAICNPLLYTVVMSRRvclKLAAGSYAAGFLNSLI---HTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDTHV 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  202 NKIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVI 281
Cdd:cd15411 171 NEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSYSLGQDKVA 250

                       250       260       270
                ....*....|....*....|....*....|
gi 6009737  282 STSLAYAIpPMLNPIIYVLNTAEITNTIRK 311
Cdd:cd15411 251 SVFYTVVI-PMLNPLIYSLRNKEVKNALRR 279

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

45-311

1.74e-45

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 155.88 E-value: 1.74e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15417  14 TLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTECFLLAA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFM---FNSIIVASMVSlvtNISFCKSNVIQSYLCDHGPMFRMACNDNNI 201
Cdd:cd15417  94 MAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLggfLNSLIQTVSMF---QLSFCGPNVIDHFFCDIPPLLSLSCSDTFI 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  202 NKIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVI 281
Cdd:cd15417 171 SQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSHSQDQDKVA 250

                       250       260       270
                ....*....|....*....|....*....|
gi 6009737  282 STSLAYAIpPMLNPIIYVLNTAEITNTIRK 311
Cdd:cd15417 251 SVFYTVVI-PMLNPLIYSLRNKEIKDALKR 279

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

45-311

2.48e-45

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 155.66 E-value: 2.48e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15407  14 TLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFATVENFLLAS 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVnnTSMISIFSAV------FMFNSIIVASMVSLvtniSFCKSNVIQSYLCDHGPMFRMACND 198
Cdd:cd15407  94 MAYDRHAAVCKPLHYTTTM--TTKVCACLTIgcyvcgFLNASIHTGNTFRL----SFCKSNVINHFFCDIPPVLALSCSD 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  199 NNINKIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNS 278
Cdd:cd15407 168 IHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSMDTD 247

                       250       260       270
                ....*....|....*....|....*....|...
gi 6009737  279 RVISTSLAYAIpPMLNPIIYVLNTAEITNTIRK 311
Cdd:cd15407 248 KMASVFYTMVI-PMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

45-300

3.96e-45

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 154.74 E-value: 3.96e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15237  14 TLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVTECVLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15237  94 MAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKLACADTSLNEA 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVIstS 284
Cdd:cd15237 174 VIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTHSPDQDKMI--S 251

                       250
                ....*....|....*..
gi 6009737  285 LAYAI-PPMLNPIIYVL 300
Cdd:cd15237 252 VFYTIvTPMLNPLIYSL 268

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

45-300

6.17e-45

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 154.18 E-value: 6.17e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15911  14 TMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATECYLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15911  94 MSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCSDTSLVEL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSlllfSTSNSRVIST- 283
Cdd:cd15911 174 VTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVP----STNTSRDLNKv 249

                       250
                ....*....|....*....
gi 6009737  284 -SLAYAI-PPMLNPIIYVL 300
Cdd:cd15911 250 fSLFYTVlTPLVNPLIYSL 268

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

45-305

6.62e-45

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 154.79 E-value: 6.62e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15408  27 TLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKVISFTGCLTQLYFYAVFATTECYLLAA 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15408 107 MAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGSNVINHFFCDGPPLLALSCSDTSLNEM 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVISTs 284
Cdd:cd15408 187 LLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLFYGSLAFMYLRPSSRYSLDLDKVASV- 265

                       250       260
                ....*....|....*....|.
gi 6009737  285 LAYAIPPMLNPIIYVLNTAEI 305
Cdd:cd15408 266 FYTVVIPMLNPLIYSLRNKEV 286

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

45-305

8.52e-45

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 154.04 E-value: 8.52e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15951  14 ALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMESGIFVA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15951  94 MALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACADTRVSRA 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNS-RVIST 283
Cdd:cd15951 174 YGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFGHNVPPHvHILIA 253

                       250       260
                ....*....|....*....|..
gi 6009737  284 SLAYAIPPMLNPIIYVLNTAEI 305
Cdd:cd15951 254 NVYLLVPPMLNPIIYGVRTKQI 275

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

45-300

2.95e-44

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 152.44 E-value: 2.95e-44

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15224  14 TLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15224  94 MAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCTDMSLAEL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVISTs 284
Cdd:cd15224 174 VDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAISSFDSNKLVSV- 252

                       250
                ....*....|....*.
gi 6009737  285 LAYAIPPMLNPIIYVL 300
Cdd:cd15224 253 LYTVVTPLLNPIIYCL 268

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

45-300

1.57e-43

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 150.60 E-value: 1.57e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15914  14 IITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGITECYLLTA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15914  94 MAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLACTDTSLNVL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVIstS 284
Cdd:cd15914 174 VDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSYSLDYDRAI--A 251

                       250
                ....*....|....*..
gi 6009737  285 LAYAI-PPMLNPIIYVL 300
Cdd:cd15914 252 VVYAVlTPFFNPIIYSL 268

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

45-311

2.63e-43

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 150.21 E-value: 2.63e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15416  14 TLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVECFLLAA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15416  94 MAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKLSCSDIRLAKI 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVISTS 284
Cdd:cd15416 174 LPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYSMDQNKVVSVF 253

                       250       260
                ....*....|....*....|....*..
gi 6009737  285 LAYAIpPMLNPIIYVLNTAEITNTIRK 311
Cdd:cd15416 254 YMVVI-PMLNPLIYSLRNKEVKGALKR 279

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

45-300

4.09e-43

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 149.38 E-value: 4.09e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15915  14 SLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEAMLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFnSIIVASMVSLVTN-ISFCKSNVIQSYLCDHGPMFRMACNDNNINK 203
Cdd:cd15915  94 MAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVT-GFFHALMHTVMTSrLPFCGPNKINHFFCDIKPLLKLACGDTSLNL 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  204 IMGFLYTTLYLIAPMLVIFLSYL--GIFLVVsKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRvI 281
Cdd:cd15915 173 WLLNIVTGSIALGTFILTLLSYIyiISFLLL-KVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGDSLEQDR-I 250

                       250
                ....*....|....*....
gi 6009737  282 STSLAYAIPPMLNPIIYVL 300
Cdd:cd15915 251 VALLYTVVTPVLNPLIYTL 269

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

45-300

1.14e-42

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 148.36 E-value: 1.14e-42

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15940  14 TLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIFLLTI 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15940  94 MAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACTDTYLIDI 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATwERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTsnSRVISTs 284
Cdd:cd15940 174 LIVSNSGLISLVCFVALLGSYIVILVSLRKRST-EGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFSE--DKVVSV- 249

                       250
                ....*....|....*.
gi 6009737  285 LAYAIPPMLNPIIYVL 300
Cdd:cd15940 250 FYTVVTPLLNPIIYTL 265

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

20-311

1.40e-42

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 148.78 E-value: 1.40e-42

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   20 FFILGLSGIPYSNLYYIFIFIIYFIT-VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQY 98
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVnVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   99 ISYNACLVNMFFVFLFSSMQSLTLVVMAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKS 178
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  179 NVIQSYLCDHGPMFRMACNDNNINKIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIY 258
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 6009737  259 FLPIFFTYLTSLLLFSTSNSRVISTSLAYAIpPMLNPIIYVLNTAEITNTIRK 311
Cdd:cd15944 241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVI-PMLNPLIYSLRNKDVKEAFKK 292

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

45-305

1.61e-42

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 148.24 E-value: 1.61e-42

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15420  14 TLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTECVLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15420  94 MSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLACADTWINEI 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVIstS 284
Cdd:cd15420 174 LIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNSAEQEKIL--S 251

                       250       260
                ....*....|....*....|..
gi 6009737  285 LAYA-IPPMLNPIIYVLNTAEI 305
Cdd:cd15420 252 LFYSlFNPMLNPLIYSLRNKQV 273

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

45-300

1.82e-42

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 147.90 E-value: 1.82e-42

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15430  14 ILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECVLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15430  94 MAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVDISLNEI 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVIstS 284
Cdd:cd15430 174 IMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKNAQISDKLI--T 251

                       250
                ....*....|....*..
gi 6009737  285 LAYAI-PPMLNPIIYVL 300
Cdd:cd15430 252 LFYGVvTPMLNPIIYSL 268

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

45-311

1.93e-42

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 148.35 E-value: 1.93e-42

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15945  27 TLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIPFYGCALQMFFFAAFADAECLLLAV 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15945 107 MAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGSNTINHFFCDIPPLLALSCSDTQINEL 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVISTS 284
Cdd:cd15945 187 LLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLFYGTLLFMYLRPSSSYSLDTDKMTSVF 266

                       250       260
                ....*....|....*....|....*..
gi 6009737  285 LAYAIpPMLNPIIYVLNTAEITNTIRK 311
Cdd:cd15945 267 YTLVI-PMLNPLIYSLRNKDVKEALKK 292

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

45-305

4.25e-42

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 147.22 E-value: 4.25e-42

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15236  14 TVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSFLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15236  94 MAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTSLNEL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLtsLLLFSTSNSRVISTS 284
Cdd:cd15236 174 VIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYF--FPSSNNSSDKDIVAS 251

                       250       260
                ....*....|....*....|..
gi 6009737  285 LAY-AIPPMLNPIIYVLNTAEI 305
Cdd:cd15236 252 VMYtVVTPMLNPFIYSLRNRDI 273

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

45-307

1.34e-41

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 145.62 E-value: 1.34e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15429  14 TLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEFILLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15429  94 MAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDTSLNEV 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVIstS 284
Cdd:cd15429 174 AILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSSALQEKMI--S 251

                       250       260
                ....*....|....*....|....
gi 6009737  285 LAYA-IPPMLNPIIYVLNTAEITN 307
Cdd:cd15429 252 LFYAvVTPMLNPLIYSLRNKEVKG 275

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

46-305

1.54e-41

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 145.43 E-value: 1.54e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVVM 125
Cdd:cd15948  16 LLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMESAVLLAM 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  126 AYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKIM 205
Cdd:cd15948  96 AFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACGDTRFNNIY 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  206 GFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVISTSL 285
Cdd:cd15948 176 GIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHRFARHVAPHVHILLAN 255

                       250       260
                ....*....|....*....|.
gi 6009737  286 AYAI-PPMLNPIIYVLNTAEI 305
Cdd:cd15948 256 FYLLfPPMMNPIVYGVKTKQI 276

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

45-305

2.46e-41

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 144.94 E-value: 2.46e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15233  14 TIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCFLLTA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15233  94 MAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSCSSTHLNEL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVISTs 284
Cdd:cd15233 174 LLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVYSSDKDKVIGI- 252

                       250       260
                ....*....|....*....|.
gi 6009737  285 LAYAIPPMLNPIIYVLNTAEI 305
Cdd:cd15233 253 LNTVLSPMLNPLIYSLRNKDV 273

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

17-305

2.50e-41

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 145.31 E-value: 2.50e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   17 PEYFFILGLSGI-PYSNLYYIFIFIIYFITVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFD 95
Cdd:cd15949   1 PSTFILLGIPGLePLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   96 SQYISYNACLVNMFFVFLFSSMQSLTLVVMAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISF 175
Cdd:cd15949  81 SNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPW 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  176 CKSNVIQSYLCDHGPMFRMACNDNNINKIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLV 255
Cdd:cd15949 161 YRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 6009737  256 GIYFLPIFFTYLTSllLFSTSNSRVISTSLA---YAIPPMLNPIIYVLNTAEI 305
Cdd:cd15949 241 LAFYVPIAVSSLIH--RFGQNVPPPTHILLAnfyLLIPPMLNPIVYGVRTKQI 291

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

45-311

2.66e-41

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 145.16 E-value: 2.66e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15413  14 TVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELFLLSA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFnSIIVASMVSLVT-NISFCKSNVIQSYLCDHGPMFRMACNDNNINK 203
Cdd:cd15413  94 MAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLY-SFFVALFHTIKTfRLSFCGSNVINHFYCDDLPLLALSCSDTHEKE 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  204 IMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVIST 283
Cdd:cd15413 173 LIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSHSLDTDKMASV 252

                       250       260
                ....*....|....*....|....*...
gi 6009737  284 SLAYAIpPMLNPIIYVLNTAEITNTIRK 311
Cdd:cd15413 253 FYTLVI-PMLNPLIYSLRNKEVKDALKK 279

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

46-313

3.93e-41

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 144.57 E-value: 3.93e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737     46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVVM 125
Cdd:pfam13853   9 FLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAM 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737    126 AYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKIM 205
Cdd:pfam13853  89 AVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKVNNIY 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737    206 GFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSllLFSTSNSRVISTSL 285
Cdd:pfam13853 169 GLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVH--RFGHNVPPLLQIMM 246

                         250       260       270
                  ....*....|....*....|....*....|.
gi 6009737    286 AYA---IPPMLNPIIYVLNTAEITNTIRKGF 313
Cdd:pfam13853 247 ANAylfFPPVLNPIVYSVKTKQIRDCVKRML 277

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

45-311

3.94e-41

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 144.48 E-value: 3.94e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15415  14 TLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEGFLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15415  94 MAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSDTHINEL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVISTS 284
Cdd:cd15415 174 LLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYSLEQEKVSAVF 253

                       250       260
                ....*....|....*....|....*..
gi 6009737  285 LAYAIpPMLNPIIYVLNTAEITNTIRK 311
Cdd:cd15415 254 YTLVI-PMLNPLIYSLRNKDVKDALKR 279

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

46-305

2.22e-40

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 142.65 E-value: 2.22e-40

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVVM 125
Cdd:cd15954  15 MVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGMESGVLMLM 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  126 AYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKIM 205
Cdd:cd15954  95 ALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACANIRVDAIY 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  206 GFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFS--TSNSRVIST 283
Cdd:cd15954 175 GLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRFGGHhiTPHIHIIMA 254

                       250       260
                ....*....|....*....|..
gi 6009737  284 SLAYAIPPMLNPIIYVLNTAEI 305
Cdd:cd15954 255 NLYLLLPPMMNPIVYGVKTKQI 276

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

45-305

2.22e-40

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 142.57 E-value: 2.22e-40

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15228  14 TLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTECLLYTV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15228  94 MAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLACADTSIAET 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLtslllfSTSNSRVISTS 284
Cdd:cd15228 174 VSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYT------QPTPSPVLVTP 247

                       250       260
                ....*....|....*....|....
gi 6009737  285 ---LAYAIPPMLNPIIYVLNTAEI 305
Cdd:cd15228 248 vqiFNNVVTPMLNPLIYTLRNKEV 271

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

45-316

9.34e-40

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 141.02 E-value: 9.34e-40

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15414  14 TLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAECFLLAS 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15414  94 MAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSLSCADTQINKW 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVISTs 284
Cdd:cd15414 174 VLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSSSLDLDKVVSV- 252

                       250       260       270
                ....*....|....*....|....*....|..
gi 6009737  285 LAYAIPPMLNPIIYVLNTAEITNTIRKGFKNR 316
Cdd:cd15414 253 FYTAVIPMLNPLIYSLRNKEVKDALRRTIRRK 284

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

45-305

1.61e-39

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 140.28 E-value: 1.61e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFL-FDSQYISYNACLVNMFFVFLFSSMQSLTLV 123
Cdd:cd15916  14 TVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLePGGKVISFGGCVAQLYFFHFLGSTECFLYT 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  124 VMAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINK 203
Cdd:cd15916  94 LMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACADTTINE 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  204 IMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLlfSTSNSRVIST 283
Cdd:cd15916 174 LVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS--KEALDGVIAV 251

                       250       260
                ....*....|....*....|..
gi 6009737  284 sLAYAIPPMLNPIIYVLNTAEI 305
Cdd:cd15916 252 -FYTVVTPLLNPLIYTLRNKEV 272

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

45-300

1.82e-39

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 140.07 E-value: 1.82e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15947  14 TLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGSTECVLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMfnSIIVASMV--SLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNIN 202
Cdd:cd15947  94 MAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWL--SGLANSLLqtTLTLQLPLCGHHTLDHFFCEVPALIKLACVDTTFN 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  203 KIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVIs 282
Cdd:cd15947 172 ELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSYSQDQGKFI- 250

                       250
                ....*....|....*....
gi 6009737  283 tSLAYA-IPPMLNPIIYVL 300
Cdd:cd15947 251 -SLFYTvVTPTLNPLIYTL 268

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

46-305

7.16e-39

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 138.75 E-value: 7.16e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVVM 125
Cdd:cd15955  15 VLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFESGILLAM 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  126 AYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVT-NISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15955  95 ALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIKlRLHHFRSTVISHSYCEHMAVVKLAADDVRVNKI 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVISTS 284
Cdd:cd15955 175 YGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHHVAPYVHILLS 254

                       250       260
                ....*....|....*....|..
gi 6009737  285 LAY-AIPPMLNPIIYVLNTAEI 305
Cdd:cd15955 255 NLYlLVPPVLNPIVYGVKTKQI 276

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

45-306

1.02e-38

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 138.38 E-value: 1.02e-38

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15428  14 TVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITECALLSV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15428  94 MSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLASTDTHQAEM 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVISTS 284
Cdd:cd15428 174 AMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSSTSKEYDKMISVF 253

                       250       260
                ....*....|....*....|..
gi 6009737  285 LAyAIPPMLNPIIYVLNTAEIT 306
Cdd:cd15428 254 YI-IVTPMLNPLIYSLRNKEVK 274

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

45-305

1.43e-38

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 137.69 E-value: 1.43e-38

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15956  14 SLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAMESGVLVA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15956  94 MALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACGATTVDSL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNS-RVIST 283
Cdd:cd15956 174 YGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFGHSVPSAaHVLLS 253

                       250       260
                ....*....|....*....|..
gi 6009737  284 SLAYAIPPMLNPIIYVLNTAEI 305
Cdd:cd15956 254 NLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

45-309

7.66e-38

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 135.64 E-value: 7.66e-38

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15942  14 TLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAECFLYTV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15942  94 MAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADTAFNEL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSlllfSTSNSRVISTS 284
Cdd:cd15942 174 VTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRP----GSQDPLDGVVA 249

                       250       260
                ....*....|....*....|....*.
gi 6009737  285 LAYA-IPPMLNPIIYVLNTAEITNTI 309
Cdd:cd15942 250 VFYTtVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

45-300

1.41e-37

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 135.03 E-value: 1.41e-37

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15939  14 TVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIFLLTV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15939  94 MAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACTDTYVIGL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYlGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVISTS 284
Cdd:cd15939 174 LVVANSGLICLLSFLILLISY-IVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTFPIDKVVAVFYT 252

                       250
                ....*....|....*.
gi 6009737  285 LayaIPPMLNPIIYVL 300
Cdd:cd15939 253 I---ITPMLNPLIYTL 265

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

45-300

7.51e-37

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 133.10 E-value: 7.51e-37

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15226  14 TVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMVLLIA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15226  94 MAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLACTDTYVLEL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATwERRLKALKTCVSHLLLVGIYFLPIFFTYltsLLLFSTSNSRVISTS 284
Cdd:cd15226 174 MVVANSGLISLVCFLLLLISYIVILVTVRKHSS-GGSSKALSTCSAHITVVVLFFGPCIFIY---VWPFSTFPVDKFLAV 249

                       250
                ....*....|....*.
gi 6009737  285 LAYAIPPMLNPIIYVL 300
Cdd:cd15226 250 FYTVITPLLNPIIYTL 265

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

45-305

7.51e-37

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 133.31 E-value: 7.51e-37

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15405  14 TVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECYVLTA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVN-NTSMISIFSAVFMFNSIIVASMVSLVtNISFCKSNVIQSYLCDHGPMFRMACNDNNINK 203
Cdd:cd15405  94 MAYDRYVAICNPLLYTVTMSpQVCSLLMLGSYVMGFAGAMAHTGCML-RLTFCDSNIINHYMCDILPLLQLSCTSTYVNE 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  204 IMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTsNSRVIST 283
Cdd:cd15405 173 LVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGSV-NQGKVSS 251

                       250       260
                ....*....|....*....|..
gi 6009737  284 SLAYAIPPMLNPIIYVLNTAEI 305
Cdd:cd15405 252 VFYTNVVPMLNPLIYSLRNKDV 273

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

45-311

5.11e-36

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 131.06 E-value: 5.11e-36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15418  15 TLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSECFLLAA 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15418  95 MAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACDDTRVYEL 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVISTs 284
Cdd:cd15418 175 ILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSSHTPDRDKVVAL- 253

                       250       260
                ....*....|....*....|....*..
gi 6009737  285 LAYAIPPMLNPIIYVLNTAEITNTIRK 311
Cdd:cd15418 254 FYTVVNPLLNPLIYSLRNKDVKEALKK 280

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

45-300

1.41e-35

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 129.76 E-value: 1.41e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15936  14 TWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEVFLLSV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15936  94 MAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACTDTFLLEL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLgIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNsrviSTS 284
Cdd:cd15936 174 LMVSNSGLVTLLIFFILLISYT-VILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTFPMDK----AVS 248

                       250
                ....*....|....*..
gi 6009737  285 LAYA-IPPMLNPIIYVL 300
Cdd:cd15936 249 VLYTvITPMLNPMIYTL 265

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

45-309

1.84e-35

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 129.42 E-value: 1.84e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15434  14 TLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGGTECVLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNT---SMISIFSAVFMFNSIIvasMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNI 201
Cdd:cd15434  94 MAYDRYAAVCQPLHYTVVMHPRlcwKLVAMSWLIGFGNSLV---LSPLTLSLPRCGHHRVDHFFCEMPALIKLACVDTTA 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  202 NKIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVI 281
Cdd:cd15434 171 YEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSVSQDQGKFL 250

                       250       260
                ....*....|....*....|....*....
gi 6009737  282 stSLAYAI-PPMLNPIIYVLNTAEITNTI 309
Cdd:cd15434 251 --TLFYTIvTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

45-300

2.49e-35

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 128.97 E-value: 2.49e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15913  14 TLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTTECFFLSV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15913  94 MAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLALSCVPAPGTEL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLtSLLLFSTSNSRVISTS 284
Cdd:cd15913 174 ICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYV-SPGSGNSTGMQKIVTL 252

                       250
                ....*....|....*.
gi 6009737  285 LAYAIPPMLNPIIYVL 300
Cdd:cd15913 253 FYSVVTPLLNPLIYSL 268

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

45-305

4.18e-34

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 126.05 E-value: 4.18e-34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15432  14 TLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGSTECVLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFM--FNSIIVASMVSLVtnISFCKSNVIQSYLCDHGPMFRMACNDNNIN 202
Cdd:cd15432  94 MAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWIsgFANSLVQSTLTLK--MPRCGRRRVDHFFCEVPALLKLSCVDTTAN 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  203 KIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVIs 282
Cdd:cd15432 172 EAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNSSHDRGKMV- 250

                       250       260
                ....*....|....*....|....
gi 6009737  283 tSLAYA-IPPMLNPIIYVLNTAEI 305
Cdd:cd15432 251 -ALFYGiITPMLNPLIYTLRNKDV 273

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

45-300

5.75e-34

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 125.67 E-value: 5.75e-34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15946  14 ILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECTLFSV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISI--FSAVFMFNSIIVASMVSLvtNISFCKSNVIQSYLCDHGPMFRMACNDNNIN 202
Cdd:cd15946  94 MAYDRYVAICHPLRYKVIMSWGLCILMvaGSWVCGVFSSLLHTFFTM--RLPYCGPNEINHYFCEVPAVLKLACADTSLN 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  203 KIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVIs 282
Cdd:cd15946 172 EMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNYSPERDKKI- 250

                       250
                ....*....|....*....
gi 6009737  283 tSLAYAI-PPMLNPIIYVL 300
Cdd:cd15946 251 -SLFYNVfTALLNPVIYSL 268

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

45-305

7.15e-34

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 125.23 E-value: 7.15e-34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15424  14 TILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTECLLLGA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSM----ISIFSAVFMFNSIIVASMVSLvtniSFCKSNVIQSYLCDHGPMFRMACNDNN 200
Cdd:cd15424  94 MAYDRYLAICHPLLYAAAMGRWRQlqlaLSCWAIGFLLSVINVGCTLRH----PFCGPNHINHFFCELPVVLKLACADTH 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  201 INKIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRV 280
Cdd:cd15424 170 ITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGSTPDRDKQ 249

                       250       260
                ....*....|....*....|....*
gi 6009737  281 ISTsLAYAIPPMLNPIIYVLNTAEI 305
Cdd:cd15424 250 IAV-FYIVITPLLNPIIYTLRNKDV 273

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

45-300

4.04e-33

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 123.06 E-value: 4.04e-33

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15938  14 VLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFLLTV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15938  94 MAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACTDTCVTEL 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLvvsKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSlllFSTSNSRVISTS 284
Cdd:cd15938 174 LMVSNSGLISTVCFVVLVTSYTTILV---TIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARP---FSTFPVDKHVSV 247

                       250
                ....*....|....*.
gi 6009737  285 LAYAIPPMLNPIIYVL 300
Cdd:cd15938 248 LYNVITPMLNPLIYTL 263

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

45-300

5.79e-32

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 120.25 E-value: 5.79e-32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSL-HSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLV 123
Cdd:cd15935  14 ILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEMLLLT 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  124 VMAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINK 203
Cdd:cd15935  94 LMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIKLACMDTYVVE 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  204 IMGFLYTTLYLIAPMLVIFLSYlGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSlllFSTSNSRVIST 283
Cdd:cd15935 174 VLMVANSGLLSLVCFLVLLVSY-GIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRP---FSSSSVDKVAS 249

                       250
                ....*....|....*..
gi 6009737  284 SLAYAIPPMLNPIIYVL 300
Cdd:cd15935 250 VFYTLITPALNPLIYTL 266

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

45-305

2.01e-30

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 116.10 E-value: 2.01e-30

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHS-PKYIGVFNLALADIGETNALIPNMMKTFL-FDSQYISYNACLVNMFFVFLFSSMQSLTL 122
Cdd:cd15941  14 TVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLtLSGRTISFEGCVVQLYAFHFLASTECFLY 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  123 VVMAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNIN 202
Cdd:cd15941  94 TVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLACADTTIN 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  203 KIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSlllfSTSNSRVIS 282
Cdd:cd15941 174 ELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQP----SSSQAGAGA 249

                       250       260
                ....*....|....*....|....
gi 6009737  283 TSLAYAI-PPMLNPIIYVLNTAEI 305
Cdd:cd15941 250 PAVFYTIvTPMLNPFIYTLRNKEV 273

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

48-300

3.84e-30

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 115.22 E-value: 3.84e-30

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   48 GNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVVMAY 127
Cdd:cd15937  17 GNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAAEMFLLVAMAY 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  128 DRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKIMGF 207
Cdd:cd15937  97 DRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIKLACTNTYTVELLMF 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  208 LYTTLYLIAPMLVIFLSYlGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTsnSRVISTsLAY 287
Cdd:cd15937 177 SNSGLVILLCFLLLLISY-AFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSFPM--DKVVAV-FHT 252

                       250
                ....*....|...
gi 6009737  288 AIPPMLNPIIYVL 300
Cdd:cd15937 253 VIFPLLNPMIYTL 265

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

45-305

6.82e-30

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 114.89 E-value: 6.82e-30

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15433  14 TLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAECVLLAV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMACNDNNINKI 204
Cdd:cd15433  94 MAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLACGDDETTEV 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVIstS 284
Cdd:cd15433 174 QMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRYSQAHGKFV--S 251

                       250       260
                ....*....|....*....|..
gi 6009737  285 LAYAI-PPMLNPIIYVLNTAEI 305
Cdd:cd15433 252 LFYTVmTPALNPLIYTLRNKDV 273

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

48-298

5.21e-24

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 98.52 E-value: 5.21e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737     48 GNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQY-ISYNACLVNMFFVFLFSSMQSLTLVVMA 126
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWpFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737    127 YDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHgpmfrmacNDNNINKIMG 206
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVTVCFIDFP--------EDLSKPVSYT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737    207 FLYTTLYLIAPMLVIFLSYLGIFLVVSKIAT-------WERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSR 279
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASkqksserTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSR 232

                         250       260
                  ....*....|....*....|....
gi 6009737    280 VISTSLAYA-----IPPMLNPIIY 298
Cdd:pfam00001 233 LLDKALSVTlwlayVNSCLNPIIY 256

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

45-300

1.47e-17

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 81.18 E-value: 1.47e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd00637  12 GLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLTA 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFnSIIVASMVSLVTNIsfcksnviqsYLCDHGPMFRMACNDNNINKI 204
Cdd:cd00637  92 ISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLL-SLLLALPPLLGWGV----------YDYGGYCCCCLCWPDLTLSKA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIATW--------------ERRLKALKTCVSHLLLVGIYFLPIFFTYLTSL 270
Cdd:cd00637 161 YTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRirssssnssrrrrrRRERKVTKTLLIVVVVFLLCWLPYFILLLLDV 240

                       250       260       270
                ....*....|....*....|....*....|....
gi 6009737  271 LLFSTSNS----RVISTSLAYAiPPMLNPIIYVL 300
Cdd:cd00637 241 FGPDPSPLprilYFLALLLAYL-NSAINPIIYAF 273

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

45-305

9.57e-17

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 78.37 E-value: 9.57e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd14967  13 TVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCTASILNLCA 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLcdhgpmfrmacndnNINKI 204
Cdd:cd14967  93 ISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEF--------------TPNKI 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSkiatweRRLKALKTCVshlLLVGIYF---LPIFFTYLTSLLLFSTSNSRV- 280
Cdd:cd14967 159 YVLVSSVISFFIPLLIMIVLYARIFRVAR------RELKAAKTLA---IIVGAFLlcwLPFFIIYLVSAFCPPDCVPPIl 229

                       250       260
                ....*....|....*....|....*..
gi 6009737  281 --ISTSLAYaIPPMLNPIIYVLNTAEI 305
Cdd:cd14967 230 yaVFFWLGY-LNSALNPIIYALFNRDF 255

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

46-300

6.23e-09

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 56.06 E-value: 6.23e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVVM 125
Cdd:cd14969  15 VVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTLAAL 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  126 AYDRLIAICLPLRYHVIVNNTSMISI-----FSAVFMFNSII-VASMVSLVTNIS-----FCKSNVIQSYLCdhgpmfrm 194
Cdd:cd14969  95 AFERYLVIVRPLKAFRLSKRRALILIafiwlYGLFWALPPLFgWSSYVPEGGGTScsvdwYSKDPNSLSYIV-------- 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  195 acndnninkimgFLYTTLYLIaPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVS-------HLLLVGIYFLPIFFTYL 267
Cdd:cd14969 167 ------------SLFVFCFFL-PLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRtkkaekkVAKMVLVMIVAFLIAWT 233

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 6009737  268 --TSLLLFSTSNSRVISTSLAYAIPPML-------NPIIYVL 300
Cdd:cd14969 234 pyAVVSLYVSFGGESTIPPLLATIPALFaksstiyNPIIYVF 275

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

45-300

1.45e-07

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 51.79 E-value: 1.45e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALAD--IGETnaLIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTL 122
Cdd:cd15055  14 TVLGNLLVIISISHFKQLHTPTNLLLLSLAVADflVGLL--VMPFSMIRSIETCWYFGDTFCKLHSSLDYILTSASIFNL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  123 VVMAYDRLIAICLPLRYHV-IVNNTSMISIFSAVFmfnsiivasmVSLVTNISFCKSNVIQSylcdhGPMFRMACNDN-- 199
Cdd:cd15055  92 VLIAIDRYVAVCDPLLYPTkITIRRVKICICLCWF----------VSALYSSVLLYDNLNQP-----GLIRYNSCYGEcv 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  200 -NINKIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIAtweRRLKALKTCVSHL-------------------LLVGIY- 258
Cdd:cd15055 157 vVVNFIWGVVDLVLTFILPCTVMIVLYMRIFVVARSQA---RAIRSHTAQVSLEgsskkvskkserkaaktlgIVVGVFl 233

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 6009737  259 --FLPIFFTYLTSLLLFSTSNSRVISTSLAYaIPPMLNPIIYVL 300
Cdd:cd15055 234 lcWLPYYIVSLVDPYISTPSSVFDVLIWLGY-FNSCLNPLIYAL 276

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

45-166

4.56e-07

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 50.45 E-value: 4.56e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSL-HSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLV 123
Cdd:cd15104  13 IITGNLLVIVALLKLIRKkDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITSCAASVLSLA 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 6009737  124 VMAYDRLIAICLPLRYHVIVNNTSMISiFSAVFMFNSIIVASM 166
Cdd:cd15104  93 AIAFDRYLALKQPLRYKQIMTGKSAGA-LIAGLWLYSGLIGFL 134

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

46-298

1.18e-06

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 49.13 E-value: 1.18e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFF--VFLFSSMqsLTLV 123
Cdd:cd14993  15 LVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLqgVSVSASV--LTLV 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  124 VMAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASM--VSLVTNISFCKSNVIQSYLCDH---GPMFRMACNd 198
Cdd:cd14993  93 AISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLlvVYELEEIISSEPGTITIYICTEdwpSPELRKAYN- 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  199 nninkimGFLYTTLYLIaPMLVIFLSYLGIFLVV-----------SKIATWERRLKALKTCVSHLLLVGIYF----LPIf 263
Cdd:cd14993 172 -------VALFVVLYVL-PLLIISVAYSLIGRRLwrrkppgdrgsANSTSSRRILRSKKKVARMLIVVVVLFalswLPY- 242

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 6009737  264 ftYLTSLLLFSTSNSRVISTSLAYAIPPML----------NPIIY 298
Cdd:cd14993 243 --YVLSILLDFGPLSSEESDENFLLILPFAqllgysnsaiNPIIY 285

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

46-144

1.19e-06

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 49.18 E-value: 1.19e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPnmmKTFLFDSQY-ISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd14968  15 VLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP---LAILISLGLpTNFHGCLFMACLVLVLTQSSIFSLLA 91

                        90       100
                ....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVN 144
Cdd:cd14968  92 IAIDRYLAIKIPLRYKSLVT 111

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

45-140

3.85e-06

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 47.84 E-value: 3.85e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYI-SYNACLVNMFFVFLFSSMQSLTLV 123
Cdd:cd15005  14 SLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAVLFCFHSAFTLF 93

                        90
                ....*....|....*..
gi 6009737  124 VMAYDRLIAICLPlRYH 140
Cdd:cd15005  94 CIAVTRYMAIAHH-RFY 109

7TM_GPCR_Srsx

pfam10320

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...

46-165

8.18e-06

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.

Pssm-ID: 255903 [Multi-domain] Cd Length: 257 Bit Score: 46.43 E-value: 8.18e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737     46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMktFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVVM 125
Cdd:pfam10320   5 LFGNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIVFVV--LLFTGTQLTRNECFWMISFYIFGQTAQGPLMLMI 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 6009737    126 AYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVAS 165
Cdd:pfam10320  83 GIDRLIAVKFPIFYRLLSSSKYLFIQLIFPVIYSSFITVY 122

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

45-242

1.06e-05

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 46.29 E-value: 1.06e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPnmmktflFDSQYISYNACLVNMFFVFLFSSMQSL---- 120
Cdd:cd15058  14 IVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVP-------LGATIVVTGKWQLGNFWCELWTSVDVLcvta 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  121 ---TLVVMAYDRLIAICLPLRYHVIVNNTSMISIFSAVFmfnsiIVASMVSLV-TNISFCKSNVIQSYLCDHGPmfrmAC 196
Cdd:cd15058  87 sieTLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVW-----IVSALVSFVpIMNQWWRANDPEANDCYQDP----TC 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 6009737  197 NDNNINKIMGFLYTTLYLIAPMLVIFLSYLGIFLvvskIATWERRL 242
Cdd:cd15058 158 CDFRTNMAYAIASSVVSFYIPLLIMIFVYARVFL----IATRQLQL 199

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

45-162

1.72e-05

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 45.80 E-value: 1.72e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALAD-----IGETNALIPNMMKTFLFDSQYisynaCLVNMFFVFLFSSMQS 119
Cdd:cd15065  13 AIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADllvalLVMTFAVVNDLLGYWLFGETF-----CNIWISFDVMCSTASI 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 6009737  120 LTLVVMAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSII 162
Cdd:cd15065  88 LNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALI 130

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

45-305

1.82e-05

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 45.36 E-value: 1.82e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADigetnaLIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLT--- 121
Cdd:cd14972  12 IVVENSLVLAAIIKNRRLHKPMYILIANLAAAD------LLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLasa 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  122 --LVVMAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFnSIIVASMVSLVTNISFCKSNVIqSYLCDHGPMFRMACndn 199
Cdd:cd14972  86 ysLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVW-SVLLALLPVLGWNCVLCDQESC-SPLGPGLPKSYLVL--- 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  200 ninkimgflyTTLYLIAPMLVIFLSYLGIFLVV----SKIATWERR---------LKALKTCVSHLLLVGIYFLPIFfty 266
Cdd:cd14972 161 ----------ILVFFFIALVIIVFLYVRIFWCLwrhaNAIAARQEAavpaqpstsRKLAKTVVIVLGVFLVCWLPLL--- 227

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 6009737  267 LTSLLLFSTSNSRVISTSLAYAIPPML-----NPIIYVLNTAEI 305
Cdd:cd14972 228 ILLVLDVLCPSVCDIQAVFYYFLVLALlnsaiNPIIYAFRLKEM 271

7tmA_NPYR-like

cd15203

neuropeptide Y receptors and related proteins, member of the class A family of ...

46-234

2.26e-05

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.

Pssm-ID: 320331 [Multi-domain] Cd Length: 293 Bit Score: 45.29 E-value: 2.26e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADI-----GETNALIPNMMKTFLFDSQyisynAC-LVNMFF-VFLFSSmq 118
Cdd:cd15203  15 VVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLllclvSLPFTLIYTLTKNWPFGSI-----LCkLVPSLQgVSIFVS-- 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  119 SLTLVVMAYDRLIAICLPLRyhvivnntSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFrmaCND 198
Cdd:cd15203  88 TLTLTAIAIDRYQLIVYPTR--------PRMSKRHALLIIALIWILSLLLSLPLAIFQELSDVPIEILPYCGYF---CTE 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 6009737  199 NNINKIMGFLYTTLYLIA----PMLVIFLSYLGIFLVVSK 234
Cdd:cd15203 157 SWPSSSSRLIYTISVLVLqfviPLLIISFCYFRISLKLRK 196

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

45-230

3.83e-05

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 44.54 E-value: 3.83e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPnmMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15068  14 AILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP--FAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLA 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGpmfRMACNDNNINKI 204
Cdd:cd15068  92 IAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEG---QVACLFEDVVPM 168

                       170       180
                ....*....|....*....|....*...
gi 6009737  205 MGFLYTTLY--LIAPMLVIFLSYLGIFL 230
Cdd:cd15068 169 NYMVYFNFFacVLVPLLLMLGVYLRIFL 196

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

45-236

4.55e-05

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 44.15 E-value: 4.55e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15314  14 TVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSFDITLCTASILNLCF 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTS---MISIfsavfmfnSIIVASMVSLVtnISFCKSNVIQSYLCDhgpmfrMACNDN-- 199
Cdd:cd15314  94 ISIDRYYAVCQPLLYRSKITVRVvlvMILI--------SWSVSALVGFG--IIFLELNIKGIYYNH------VACEGGcl 157

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 6009737  200 -NINKIMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIA 236
Cdd:cd15314 158 vFFSKVSSVVGSVFSFYIPAVIMLCIYLKIFLVAQRQA 195

7tmA_TRH-R

cd14995

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...

46-161

6.91e-05

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.

Pssm-ID: 320126 [Multi-domain] Cd Length: 269 Bit Score: 43.53 E-value: 6.91e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALAD-IGETNALIPNMMKTFLFDSQYI-SYNACLVNMFFVFLFSSMQSLTLV 123
Cdd:cd14995  15 IVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADlMVLVAAGLPNEIESLLGPDSWIyGYAGCLLITYLQYLGINASSLSIT 94

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 6009737  124 VMAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSI 161
Cdd:cd14995  95 AFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSL 132

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

45-188

1.07e-04

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 43.26 E-value: 1.07e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNA-----LIPNMMKTFLFDSQyisynACLVNMFFVFLFSSMQS 119
Cdd:cd15979  14 SVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFcmpftLIPNLMGTFIFGEV-----ICKAVAYLMGVSVSVST 88

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6009737  120 LTLVVMAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDH 188
Cdd:cd15979  89 FSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDRPRGHQCRH 157

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

45-154

1.74e-04

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 42.65 E-value: 1.74e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15074  14 STLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSINTLTA 93

                        90       100       110
                ....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSA 154
Cdd:cd15074  94 ISIYRYLKICHPPYGPKLSRRHVCIVIVAI 123

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

45-246

2.24e-04

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 42.43 E-value: 2.24e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15317  14 TVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLCTTSIFHLCF 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYhvivnnTSMISIfSAVFMFnsIIVASMVSLVTNISFCKSNVIQSYLCDHGPmfRMACNDNNI--- 201
Cdd:cd15317  94 IAIDRYYAVCDPLRY------PSKITV-QVAWRF--IAIGWLVPGIYTFGLIYTGANDEGLEEYSS--EISCVGGCQllf 162

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 6009737  202 NKIMGFLYTTLYLIaPMLVIFLSYLGIFLV----VSKIATWERRLKALK 246
Cdd:cd15317 163 NKIWVLLDFLTFFI-PCLIMIGLYAKIFLVarrqARKIQNMEDKFRSSE 210

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

45-154

2.42e-04

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 41.84 E-value: 2.42e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIgeTNALIpNMMKTFLFDSQYISYN---AC-LVNMFFVF-LFSSmqS 119
Cdd:cd15196  14 ALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADL--LVALF-NVLPQLIWDITYRFYGgdlLCrLVKYLQVVgMYAS--S 88

                        90       100       110
                ....*....|....*....|....*....|....*
gi 6009737  120 LTLVVMAYDRLIAICLPLRYHVIVNNTSMISIFSA 154
Cdd:cd15196  89 YVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAIA 123

7tmA_leucokinin-like

cd15393

leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...

46-138

2.50e-04

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.

Pssm-ID: 320515 [Multi-domain] Cd Length: 288 Bit Score: 42.01 E-value: 2.50e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVVM 125
Cdd:cd15393  15 VVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVNVSVFTLTVI 94

                        90
                ....*....|...
gi 6009737  126 AYDRLIAICLPLR 138
Cdd:cd15393  95 AVDRYRAVIHPLK 107

7tmA_Histamine_H3R_H4R

cd15048

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...

45-145

2.66e-04

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320176 [Multi-domain] Cd Length: 296 Bit Score: 41.91 E-value: 2.66e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15048  14 TVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDYTLCTASALTIVL 93

                        90       100
                ....*....|....*....|.
gi 6009737  125 MAYDRLIAICLPLRYHVIVNN 145
Cdd:cd15048  94 ISLDRYLSVTKAVKYRAKQTK 114

7tmA_alpha1B_AR

cd15326

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

46-304

2.76e-04

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320449 [Multi-domain] Cd Length: 261 Bit Score: 41.80 E-value: 2.76e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVVM 125
Cdd:cd15326  15 IVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSLCAI 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  126 AYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVAsmvslvtnisfcksnviqsylcdhGPMF---RMACNDNNIN 202
Cdd:cd15326  95 SIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISI------------------------GPLLgwkEPAPPDDKVC 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  203 KIMGFLYTTLY-----LIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVgiyFLPiFFTYLTSLLLFSTSN 277
Cdd:cd15326 151 EITEEPFYALFsslgsFYIPLIVILVMYCRVYIVALKFSREKKAAKTLGIVVGMFILC---WLP-FFIALPLGSLFSHLK 226

                       250       260       270
                ....*....|....*....|....*....|
gi 6009737  278 SRVISTSLAYAI---PPMLNPIIYVLNTAE 304
Cdd:cd15326 227 PPETLFKIIFWLgyfNSCLNPIIYPCSSKE 256

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

45-162

3.47e-04

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 41.84 E-value: 3.47e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLfdSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15069  14 SVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISL--GFCTDFHSCLFLACFVLVLTQSSIFSLLA 91

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSII 162
Cdd:cd15069  92 VAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGI 129

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

46-234

4.81e-04

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 41.16 E-value: 4.81e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVVM 125
Cdd:cd15083  15 VVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTLAAI 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  126 AYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVA---------SMVSLVTNISFcksnviqSYLCDhgpmfrmac 196
Cdd:cd15083  95 AVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLpplfgwsryVLEGLLTSCSF-------DYLSR--------- 158

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 6009737  197 NDNNINKIMgFLYTTLYLIaPMLVIFLSYLGIFLVVSK 234
Cdd:cd15083 159 DDANRSYVI-CLLIFGFVL-PLLIIIYCYSFIFRAVRR 194

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

46-143

5.60e-04

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 41.03 E-value: 5.60e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVVM 125
Cdd:cd15325  15 VLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCII 94

                        90
                ....*....|....*...
gi 6009737  126 AYDRLIAICLPLRYHVIV 143
Cdd:cd15325  95 SIDRYIGVSYPLRYPSIM 112

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

45-298

5.80e-04

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 40.80 E-value: 5.80e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15312  14 TVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFHLCF 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFrmacndnnINKI 204
Cdd:cd15312  94 IAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGVVFSEVNLEGIEDYVALVSCTGSCVLI--------FNKL 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIA------------------TWERRLKALKTCVSHLLLVGIYFLPIFFTY 266
Cdd:cd15312 166 WGVIASLIAFFIPGTVMIGIYIKIFFVARKHAkvinnrpsvtkgdsknklSKKKERKAAKTLSIVMGVFLLCWLPFFVAT 245

                       250       260       270
                ....*....|....*....|....*....|....
gi 6009737  267 LTSLLL-FSTSNSRV-ISTSLAYaIPPMLNPIIY 298
Cdd:cd15312 246 LIDPFLnFSTPVDLFdALVWLGY-FNSTCNPLIY 278

7tmA_CCK-AR

cd15978

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...

45-186

7.19e-04

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320644 [Multi-domain] Cd Length: 278 Bit Score: 40.62 E-value: 7.19e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADI-----GETNALIPNMMKTFLFDSQyisynACLVNMFFVFLFSSMQS 119
Cdd:cd15978  14 SVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLmlclfCMPFTLIPNLLKDFIFGSA-----VCKTATYFMGISVSVST 88

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6009737  120 LTLVVMAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLC 186
Cdd:cd15978  89 FNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFTRINNSTGNMC 155

7tmA_VA_opsin

cd15082

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...

49-299

7.34e-04

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320210 [Multi-domain] Cd Length: 291 Bit Score: 40.55 E-value: 7.34e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   49 NFLVILLIVLDRSLHSPKYIGVFNLALAD-----IGETNALIPNMMKTFlfdsqYISYNACLVNMFFVFLFSSMQSLTLV 123
Cdd:cd15082  31 NFAVMLVTFRFKQLRQPLNYIIVNLSVADflvslTGGTISFLTNARGYF-----FLGVWACVLEGFAVTFFGIVALWSLA 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  124 VMAYDRLIAICLPLRYHVIVNNTSMISI-----FSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHgpmfrmacnd 198
Cdd:cd15082 106 VLAFERFFVICRPLGNIRLQGKHAALGLlfvwtFSFIWTIPPVLGWSSYTVSKIGTTCEPNWYSGNMHDH---------- 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  199 nniNKIMGFLYTTlyLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTC---VSHLLLVGIYFLPIFFTYLTSLLLFST 275
Cdd:cd15082 176 ---TYIITFFTTC--FILPLGVIFVSYGKLLQKLRKVSNTQGRLGNARKPerqVTRMVVVMIVAFMVCWTPYAAFSILVT 250

                       250       260       270
                ....*....|....*....|....*....|.
gi 6009737  276 SNSRVISTSLAYAIPP-------MLNPIIYV 299
Cdd:cd15082 251 AHPTIHLDPRLAAIPAffsktaaVYNPIIYV 281

7tmA_mAChR_DM1-like

cd15301

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...

45-139

1.05e-03

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320428 [Multi-domain] Cd Length: 270 Bit Score: 40.19 E-value: 1.05e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15301  14 TVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNASVLNLLI 93

                        90
                ....*....|....*
gi 6009737  125 MAYDRLIAICLPLRY 139
Cdd:cd15301  94 ISFDRYFSVTRPLTY 108

7tmA_alpha2B_AR

cd15321

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

45-266

1.13e-03

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320444 [Multi-domain] Cd Length: 268 Bit Score: 39.91 E-value: 1.13e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15321  20 TIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSSIVHLCA 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMfnsiiVASMVSLVTNISFCKSNVIQSYLCDhgpmfrmaCNDNniNKI 204
Cdd:cd15321 100 ISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWL-----IAAVISLPPLIYKGKQKDEQGGLPQ--------CKLN--EEA 164

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6009737  205 MGFLYTTL-YLIAPMLVIFLSYLGIFLVVSkiaTWERRLKALKTCVSHLLLvgIYFLPIFFTY 266
Cdd:cd15321 165 WYILSSSIgSFFAPCLIMILVYLRIYLIAK---NREKRFTFVLAVVIGVFV--LCWFPFFFSY 222

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

46-300

1.99e-03

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 39.33 E-value: 1.99e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVVM 125
Cdd:cd15073  15 TISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLLTVV 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  126 AYDRLIAICLPLRYHVIVNNTSMISIfsAVFMFNSIIVASMVSLVTNisfCKSNVIQSYLCdhgpMFRMACNDNN-INKI 204
Cdd:cd15073  95 AVDRYLTICRPDLGRKMTTNTYTVMI--LLAWTNAFFWAAMPLVGWA---SYALDPTGATC----TINWRKNDSSfVSYT 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MgfLYTTLYLIAPMLVIFLSYLGIFLVVSKIAT----------WERRLKALKTCVSHLLLvgiyFLPIFFTYLTSLLLFS 274
Cdd:cd15073 166 M--SVIVVNFIVPLAVMFYCYYNVSRFVKKVLAsdclesvnidWTDQNDVTKMSVIMIVM----FLVAWSPYSIVCLWAS 239

                       250       260       270
                ....*....|....*....|....*....|...
gi 6009737  275 TSNSRVISTSLAyAIPPML-------NPIIYVL 300
Cdd:cd15073 240 FGEPKKIPPWMA-IIPPLFaksstfyNPCIYVI 271

7tmA_alpha1_AR

cd15062

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...

45-162

2.54e-03

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320190 [Multi-domain] Cd Length: 261 Bit Score: 39.01 E-value: 2.54e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15062  14 AIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSLCV 93

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSII 162
Cdd:cd15062  94 ISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVI 131

7tmA_5-HT6

cd15054

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...

45-139

2.56e-03

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320182 [Multi-domain] Cd Length: 267 Bit Score: 39.02 E-value: 2.56e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15054  14 TVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSASILNLCV 93

                        90
                ....*....|....*
gi 6009737  125 MAYDRLIAICLPLRY 139
Cdd:cd15054  94 ISLDRYLLIISPLRY 108

7tmA_GPRnna14-like

cd15001

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...

46-298

2.71e-03

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320132 [Multi-domain] Cd Length: 266 Bit Score: 38.80 E-value: 2.71e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVnMFFVFLFSSMQS-LTLVV 124
Cdd:cd15001  14 LIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKA-VAYLQLLSFICSvLTLTA 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHGpmfrmacndnninkI 204
Cdd:cd15001  93 ISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHCQKA--------------W 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFlsyLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIF-FTYLTSLLLFSTSNS----- 278
Cdd:cd15001 159 PSTLYSRLYVVYLAIVIF---FIPLIVMTFAYARDTRKQVIKMLISVVVLFAVCWGPLLiDNLLVSFDVISTLHTqalky 235

                       250       260
                ....*....|....*....|.
gi 6009737  279 -RVISTSLAYAiPPMLNPIIY 298
Cdd:cd15001 236 mRIAFHLLSYA-NSCINPIIY 255

7tmA_CCK_R

cd15206

cholecystokinin receptors, member of the class A family of seven-transmembrane G ...

46-138

3.01e-03

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320334 [Multi-domain] Cd Length: 269 Bit Score: 38.53 E-value: 3.01e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGET-----NALIPNMMKTFLFDSQyisynACLVNMFFVFLFSSMQSL 120
Cdd:cd15206  15 VVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAvfcmpFTLVGQLLRNFIFGEV-----MCKLIPYFQAVSVSVSTF 89

                        90
                ....*....|....*...
gi 6009737  121 TLVVMAYDRLIAICLPLR 138
Cdd:cd15206  90 TLVAISLERYFAICHPLK 107

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

45-261

3.22e-03

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 38.58 E-value: 3.22e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15012  13 CFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYTASIGILVV 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVN------NTSMISIFSAVFMFNSIIVASMVS-LVTNISFCKSNVIqsylcdhgpmfrMACN 197
Cdd:cd15012  93 ISVERYIAILHPLRCKQLLTaarlrvTIVTVWLTSAVYNTPYFVFSQTVEiLVTQDGQEEEICV------------LDRE 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6009737  198 DNNINKIMGFLYTTLYLIaPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLP 261
Cdd:cd15012 161 MFNSKLYDTINFIVWYLI-PLLIMTVLYSKISIVLWKSSSIEARRKVVRLLVAVVVSFALCNLP 223

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

45-139

3.67e-03

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 38.37 E-value: 3.67e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQY-ISYNACLVNMFFVFLFSSMQSLTLV 123
Cdd:cd15304  14 TIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWpLPSKLCAVWIYLDVLFSTASIMHLC 93

                        90
                ....*....|....*.
gi 6009737  124 VMAYDRLIAICLPLRY 139
Cdd:cd15304  94 AISLDRYIAIRNPIHH 109

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

45-158

3.69e-03

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 38.24 E-value: 3.69e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLV----NMFFVFLFSSMQS- 119
Cdd:cd15103  14 SLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEqhidNVIDSMICSSLLAs 93

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 6009737  120 -LTLVVMAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMF 158
Cdd:cd15103  94 iCSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVF 133

7tmA_Adenosine_R_A1

cd15071

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...

45-298

3.78e-03

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.

Pssm-ID: 341323 [Multi-domain] Cd Length: 290 Bit Score: 38.29 E-value: 3.78e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPnmMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15071  14 SVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAIIINIGPQTEFYSCLMVACPVLILTQSSILALLA 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSmisifSAVFMFNSIIVASMVSLVTNISFCKSNVIQS--YLCDHGPMFRMACNDNNIN 202
Cdd:cd15071  92 IAVDRYLRVKIPTRYKSVVTPRR-----AAVAIAGCWILSFLVGLTPMFGWNNLNAVERawAANSSMGELVIKCQFETVI 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  203 KIMGFLYTTLY--LIAPMLVIFLSYLGIFLVV-----SKIATWERR--------LKALKTCVSHLLLVGIYFLPIFFTYL 267
Cdd:cd15071 167 SMEYMVYFNFFvwVLPPLLLMLLIYLEVFYLIrkqlnKKVSSSSSDpqkyygkeLKIAKSLALILFLFALSWLPLHILNC 246

                       250       260       270
                ....*....|....*....|....*....|....
gi 6009737  268 TSlLLFSTSNSRVISTSLAYAIP---PMLNPIIY 298
Cdd:cd15071 247 IT-LFCPSCKKPMILTYIAIFLThgnSAMNPIVY 279

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

45-315

3.98e-03

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 38.35 E-value: 3.98e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQY-ISYNACLVNMFFVFLFSSMQSLTLV 123
Cdd:cd15305  14 TIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAWpLPRYLCPIWISLDVLFSTASIMHLC 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  124 VMAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNsiIVASMVSLVTNISfCKSNVIQSYLCdhgpmfrmACNDNNINK 203
Cdd:cd15305  94 AISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTIS--IGISMPIPVIGLQ-DDEKVFVNGTC--------VLNDENFVL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  204 IMGFlyttLYLIAPMLVIFLSYLGIFLVVSKIATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLLFSTSNSRVIST 283
Cdd:cd15305 163 IGSF----VAFFIPLIIMVITYCLTIQVLQRQQAINNERRASKVLGIVFFLFLIMWCPFFITNILSVLCKEACDQKLMEE 238

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 6009737  284 SLAY-----AIPPMLNPIIYVLntaeITNTIRKGFKN 315
Cdd:cd15305 239 LLNVfvwvgYVSSGINPLVYTL----FNKTYRRAFSN 271

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

46-298

4.37e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 38.22 E-value: 4.37e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSqyISYNACLVNMFFVFLFSSMQSLTLVVM 125
Cdd:cd15070  15 VVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSLGVT--IHFYSCLFMSCLLVVFTHASIMSLLAI 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  126 AYDRLIAICLPLRYHVIVNNTSmISIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYL-CDHGPMFRMacndnninKI 204
Cdd:cd15070  93 AVDRYLRVKLTVRYRIVTTQRR-IWLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTTPLqCQFTSVMRM--------DY 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  205 MGFLYTTLYLIAPMLVIFLSYLGIFLVVSKI------------ATWERRLKALKTCVSHLLLVGIYFLPIFFTYLTSLLL 272
Cdd:cd15070 164 MVYFSFFTWILIPLVIMCALYVDIFYIIRNKlsqnatgfretgAFYGREFKTAKSLALVLFLFAVCWLPLSIINCVVYFN 243

                       250       260
                ....*....|....*....|....*.
gi 6009737  273 FSTSNSRVISTSLAYAIPPMLNPIIY 298
Cdd:cd15070 244 PKVPKIALYLGILLSHANSMMNPIVY 269

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

45-181

4.82e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 38.24 E-value: 4.82e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLV----NMFFVFLFSSMQSL 120
Cdd:cd15351  14 SLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLqhmdNVIDTMICSSVVSS 93

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6009737  121 T--LVVMAYDRLIAICLPLRYHvivnntSMISIFSAVFMFNSIIVASMVSLVTNISFCKSNVI 181
Cdd:cd15351  94 LsfLGAIAVDRYITIFYALRYH------SIMTLQRAVNAIAGIWLASTVSSTLFIVYYNSNAV 150

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

45-300

5.11e-03

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 37.92 E-value: 5.11e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15318  14 IVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLCF 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  125 MAYDRLIAICLPLRYHvivnntsmiSIFSAVFMFNSIIVASMVSLVTNISFCKSNVIQSYLCDHgpMFRMACNDNN---I 201
Cdd:cd15318  94 ISIDRHCAICDPLLYP---------SKFTIRVACIFIAAGWLVPTVYTSVFLYTKAVEEGLAEL--LTSVPCVGSCqllY 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  202 NKIMGFLYTTLYLIaPMLVIFLSYLGIFLVVSKIA------------TWERRLKALKTCVshlLLVGIY---FLPIFFTY 266
Cdd:cd15318 163 NKLWGWLNFPVFFI-PCLIMIGLYVKIFIVAKRQAraiasllsdtngASKRERKAAKTLG---IAVGVYllcWLPFTIDT 238

                       250       260       270
                ....*....|....*....|....*....|....*
gi 6009737  267 LTSLLLFSTSNSRVISTSLAYA-IPPMLNPIIYVL 300
Cdd:cd15318 239 MVDSLLNFITPPLLFDIIIWFAyFNSACNPLIYVF 273

7tmA_alpha2C_AR

cd15323

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...

45-162

5.52e-03

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320446 [Multi-domain] Cd Length: 261 Bit Score: 37.99 E-value: 5.52e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15323  14 TIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSIVHLCA 93

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSII 162
Cdd:cd15323  94 ISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVI 131

7tmA_capaR

cd15134

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...

46-228

6.27e-03

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.

Pssm-ID: 320262 [Multi-domain] Cd Length: 298 Bit Score: 37.70 E-value: 6.27e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLfdSQY---ISYNACLVNMFFVFLFSSMQSLTL 122
Cdd:cd15134  15 VVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIW--QQYpwvFGEVFCKLRAFLSEMSSYASVLTI 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  123 VVMAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSII-----VASMVSLVTNISFCKSNVIQSYLCdhgpmfrmACN 197
Cdd:cd15134  93 TAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCalpfaIQTRIVYLEYPPTSGEALEESAFC--------AML 164

                       170       180       190
                ....*....|....*....|....*....|..
gi 6009737  198 DNNINKIMGF-LYTTLYLIAPMLVIFLSYLGI 228
Cdd:cd15134 165 NEIPPITPVFqLSTFLFFIIPMIAIIVLYVLI 196

7tmA_5-HT2

cd15052

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...

45-139

7.03e-03

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320180 [Multi-domain] Cd Length: 262 Bit Score: 37.68 E-value: 7.03e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQY-ISYNACLVNMFFVFLFSSMQSLTLV 123
Cdd:cd15052  14 TIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGGVWpLPLVLCLLWVTLDVLFCTASIMHLC 93

                        90
                ....*....|....*.
gi 6009737  124 VMAYDRLIAICLPLRY 139
Cdd:cd15052  94 TISLDRYMAIRYPLRT 109

7tmA_TACR

cd15390

neurokinin receptors (or tachykinin receptors), member of the class A family of ...

46-138

7.12e-03

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320512 [Multi-domain] Cd Length: 289 Bit Score: 37.66 E-value: 7.12e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIgetnalipnMMKTF--LFDSQYISYNA-------CLVNMFFVFLFSS 116
Cdd:cd15390  15 IGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADL---------LISAFntVFNFTYLLYNDwpfglfyCKFSNFVAITTVA 85

                        90       100
                ....*....|....*....|..
gi 6009737  117 MQSLTLVVMAYDRLIAICLPLR 138
Cdd:cd15390  86 ASVFTLMAISIDRYIAIVHPLR 107

7tmA_TACR-like

cd15202

tachykinin receptors and related receptors, member of the class A family of ...

45-138

7.47e-03

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320330 [Multi-domain] Cd Length: 288 Bit Score: 37.49 E-value: 7.47e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15202  14 SLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVSAYTLTA 93

                        90
                ....*....|....
gi 6009737  125 MAYDRLIAICLPLR 138
Cdd:cd15202  94 IAVDRYQAIMHPLK 107

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

46-222

7.81e-03

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 37.61 E-value: 7.81e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLvILLIVLDRSLHSPKYIGVFNLALADIGE-----TNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSL 120
Cdd:cd14978  15 IIGNIL-NLVVLTRKSMRSSTNVYLAALAVSDILVllsalPLFLLPYIADYSSSFLSYFYAYFLPYIYPLANTFQTASVW 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  121 TLVVMAYDRLIAICLPLRYHVIVN-NTSMISIFSAVFMfnSIIVASMVSLVTNISFCKSNVIQSYLCDHGPMFRMacNDN 199
Cdd:cd14978  94 LTVALTVERYIAVCHPLKARTWCTpRRARRVILIIIIF--SLLLNLPRFFEYEVVECENCNNNSYYYVIPTLLRQ--NET 169

                       170       180
                ....*....|....*....|...
gi 6009737  200 NINKIMGFLYTTLYLIAPMLVIF 222
Cdd:cd14978 170 YLLKYYFWLYAIFVVLLPFILLL 192

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

46-309

7.96e-03

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 37.24 E-value: 7.96e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   46 VIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVN--MFFVFLFSSMqsLTLV 123
Cdd:cd14982  15 LLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTglLFYINMYGSI--LFLT 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  124 VMAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFnsIIVASMVSLVTNISFCKSNviQSYLCDHGPMFRmacndNNINK 203
Cdd:cd14982  93 CISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWIL--VLVASVPLLLLRSTIAKEN--NSTTCFEFLSEW-----LASAA 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737  204 IMGFLYTTLYLIAPMLVIFLSYLGIFLVVSKIAT----WERRLKALKTCVSHLLLVGIYFLP---IFFTYLTSLLLFSTS 276
Cdd:cd14982 164 PIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKqsqkSVRKRKALRMILIVLAVFLVCFLPyhvTRILYLLVRLSFIAD 243

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 6009737  277 NSRVISTSLAYAIP-------PMLNPIIYVLNTAEITNTI 309
Cdd:cd14982 244 CSARNSLYKAYRITlclaslnSCLDPLIYYFLSKTFRKRL 283

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

45-162

8.15e-03

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 37.25 E-value: 8.15e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6009737   45 TVIGNFLVILLIVLDRSLHSPKYIGVFNLALADIGETNALIPNMMKTFLFDSQYISYNACLVNMFFVFLFSSMQSLTLVV 124
Cdd:cd15329  14 TVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVLLCTASILNLCA 93

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 6009737  125 MAYDRLIAICLPLRYHVIVNNTSMISIFSAVFMFNSII 162
Cdd:cd15329  94 ISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALI 131

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01