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Conserved domains on  [gi|5420463|dbj|BAA82321|]
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arylsulfotransferase ST1A4 [Mus musculus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
41-291 6.19e-103

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 301.18  E-value: 6.19e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5420463     41 PDDVLISTYPKSGTNWMSEIMDMIYQGGKLDKCGRAPV---YARIPFLEFSCP----GVPPGLETLKETPAPRIIKTHLP 113
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5420463    114 LSLLPQSLLDQKIKVIYVARNAKDVVVSYYNFYKMAKLHPDPGTWESFLENFMDGKVSYGSWYQHVKEWWELRRTHPVLY 193
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5420463    194 LFYEDMKENPKREIKKILEFLGRSLPEETVDLIVHHTSFKKMKENPMANYTTIPTEVmdhtiYPFMRKGTIGDWKNTFTV 273
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 5420463    274 AQSEHFDAHYAKLMTGCD 291
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
41-291 6.19e-103

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 301.18  E-value: 6.19e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5420463     41 PDDVLISTYPKSGTNWMSEIMDMIYQGGKLDKCGRAPV---YARIPFLEFSCP----GVPPGLETLKETPAPRIIKTHLP 113
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5420463    114 LSLLPQSLLDQKIKVIYVARNAKDVVVSYYNFYKMAKLHPDPGTWESFLENFMDGKVSYGSWYQHVKEWWELRRTHPVLY 193
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5420463    194 LFYEDMKENPKREIKKILEFLGRSLPEETVDLIVHHTSFKKMKENPMANYTTIPTEVmdhtiYPFMRKGTIGDWKNTFTV 273
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 5420463    274 AQSEHFDAHYAKLMTGCD 291
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 37-272 3.29e-20

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 89.21  E-value: 3.29e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5420463    37 FTAWPDDVLISTYPKSGTNWMSEIMDMIYQGGKLDKCGRaPVYAR-----IPFLEFSCPGVPPgLETLKETPAPrIIKTH 111
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIEIDFPFFPS-VDVLKDKGNT-LFSTH 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5420463   112 LPLSLLPQSLLDQKIKVIYVARNAKDVVVSYYNFYKMAKLHPDP-GTWESFLENFMDGKVSYGSWYQHVKEWWELRRTHP 190
Cdd:PLN02164 152 IPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGYWKAYQENP 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5420463   191 --VLYLFYEDMKENPKREIKKILEFLGRSLPEE-----TVDLIVHHTSFKKMKeNPMANYTTIPTEVMDhTIYP---FMR 260
Cdd:PLN02164 232 drILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSFETLK-NLEANKGEKDREDRP-AVYAnsaYFR 309

                        250
                 ....*....|..
gi 5420463   261 KGTIGDWKNTFT 272
Cdd:PLN02164 310 KGKVGDWQNYLT 321
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
125-249 6.31e-05

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 43.46  E-value: 6.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5420463  125 KIKVIYVARNakDVVVSYYNFYKMAKlhpdPGTWESF-LENF-MDGKVSY-----GSWYQHVKEW---WE--LRRT-HPV 191
Cdd:COG4424 103 DLKFIHLTRR--DKLAQAVSLVIAQQ----TGQWHSDaDDALaPTAPPEYdaeeiARLLEALQDFearWEawFARTgITP 176

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 5420463  192 LYLFYEDMKENPKREIKKILEFLGRSLPEETVDlivhhTSFKKMKENPMANYTTIPTE 249
Cdd:COG4424 177 LEITYEDLAADPVEVLNRVLDFLGVDPPLAPLR-----PALKKQADEPSDEWVARFRE 229
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
41-291 6.19e-103

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 301.18  E-value: 6.19e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5420463     41 PDDVLISTYPKSGTNWMSEIMDMIYQGGKLDKCGRAPV---YARIPFLEFSCP----GVPPGLETLKETPAPRIIKTHLP 113
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5420463    114 LSLLPQSLLDQKIKVIYVARNAKDVVVSYYNFYKMAKLHPDPGTWESFLENFMDGKVSYGSWYQHVKEWWELRRTHPVLY 193
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5420463    194 LFYEDMKENPKREIKKILEFLGRSLPEETVDLIVHHTSFKKMKENPMANYTTIPTEVmdhtiYPFMRKGTIGDWKNTFTV 273
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 5420463    274 AQSEHFDAHYAKLMTGCD 291
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 37-272 3.29e-20

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 89.21  E-value: 3.29e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5420463    37 FTAWPDDVLISTYPKSGTNWMSEIMDMIYQGGKLDKCGRaPVYAR-----IPFLEFSCPGVPPgLETLKETPAPrIIKTH 111
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIEIDFPFFPS-VDVLKDKGNT-LFSTH 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5420463   112 LPLSLLPQSLLDQKIKVIYVARNAKDVVVSYYNFYKMAKLHPDP-GTWESFLENFMDGKVSYGSWYQHVKEWWELRRTHP 190
Cdd:PLN02164 152 IPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGYWKAYQENP 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5420463   191 --VLYLFYEDMKENPKREIKKILEFLGRSLPEE-----TVDLIVHHTSFKKMKeNPMANYTTIPTEVMDhTIYP---FMR 260
Cdd:PLN02164 232 drILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSFETLK-NLEANKGEKDREDRP-AVYAnsaYFR 309

                        250
                 ....*....|..
gi 5420463   261 KGTIGDWKNTFT 272
Cdd:PLN02164 310 KGKVGDWQNYLT 321
Sulfotransfer_3 pfam13469
Sulfotransferase family;
127-220 5.50e-07

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 48.83  E-value: 5.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5420463    127 KVIYVARNAKDVVVSyyNFYKMAKLHPDPgtWESFLENFMDGKVSYgsWYQHVKEWWELRRTHP---VLYLFYEDMKENP 203
Cdd:pfam13469  83 KFIHLHRDPVDTVIS--SYCSLFGFTLSS--YSTAFLRDIGLALAR--WSRAYERLMAARARVPpgrFLDVRYEDLVADP 156

                          90
                  ....*....|....*..
gi 5420463    204 KREIKKILEFLGRSLPE 220
Cdd:pfam13469 157 EGTLRRILEFLGLPWDD 173
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
125-249 6.31e-05

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 43.46  E-value: 6.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5420463  125 KIKVIYVARNakDVVVSYYNFYKMAKlhpdPGTWESF-LENF-MDGKVSY-----GSWYQHVKEW---WE--LRRT-HPV 191
Cdd:COG4424 103 DLKFIHLTRR--DKLAQAVSLVIAQQ----TGQWHSDaDDALaPTAPPEYdaeeiARLLEALQDFearWEawFARTgITP 176

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 5420463  192 LYLFYEDMKENPKREIKKILEFLGRSLPEETVDlivhhTSFKKMKENPMANYTTIPTE 249
Cdd:COG4424 177 LEITYEDLAADPVEVLNRVLDFLGVDPPLAPLR-----PALKKQADEPSDEWVARFRE 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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