NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|929654355|dbj|BAA74846|]
View 

KIAA0823 protein [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
71-321 6.99e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.55  E-value: 6.99e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  71 ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLV 150
Cdd:COG0666   57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 151 KILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETcmayqgitqekinemrvapeqqmiadihcMIAAGQDLDWIDAQGA 230
Cdd:COG0666  137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKL-----------------------------LLEAGADVNARDNDGE 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 231 TLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVL 310
Cdd:COG0666  188 TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALI 267

                        250
                 ....*....|.
gi 929654355 311 LLELKHKHDVI 321
Cdd:COG0666  268 VKLLLLALLLL 278
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
71-321 6.99e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.55  E-value: 6.99e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  71 ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLV 150
Cdd:COG0666   57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 151 KILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETcmayqgitqekinemrvapeqqmiadihcMIAAGQDLDWIDAQGA 230
Cdd:COG0666  137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKL-----------------------------LLEAGADVNARDNDGE 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 231 TLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVL 310
Cdd:COG0666  188 TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALI 267

                        250
                 ....*....|.
gi 929654355 311 LLELKHKHDVI 321
Cdd:COG0666  268 VKLLLLALLLL 278
Ank_2 pfam12796
Ankyrin repeats (3 copies);
72-164 1.54e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 92.10  E-value: 1.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355   72 LLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHgANVNAKDNElWTPLHAAATCGHINLVK 151
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 929654355  152 ILVQYGADLLAVN 164
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 71-301 7.80e-18

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 86.23  E-value: 7.80e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  71 ALLEASLRNDAEEVRYFLKNKV---SPDLCnedGLTALHQC-CIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAAT--C 144
Cdd:PHA03095  53 LYLHYSSEKVKDIVRLLLEAGAdvnAPERC---GFTPLHLYlYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfN 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 145 GHINLVKILVQYGADLLAVNSDGNMPYD--LCEDEPTLDVIETCMAYQGITQEKINEMRVAPEQqmIAD--------IHC 214
Cdd:PHA03095 130 INPKVIRLLLRKGADVNALDLYGMTPLAvlLKSRNANVELLRLLIDAGADVYAVDDRFRSLLHH--HLQsfkprariVRE 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 215 MIAAGQDLDWIDAQGATLLHIAGANGYLRAAEL--LLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSART 292
Cdd:PHA03095 208 LIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287


                 ....*....
gi 929654355 293 SMDEMPIDL 301
Cdd:PHA03095 288 SDGNTPLSL 296
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 67-170 3.47e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.01  E-value: 3.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  67 EASVALLEASlrndaeevryflknkvsPDLCNE-------DGLTALHQCCIDNFEEIVKLLLSHGANVNA---------- 129
Cdd:cd22192   65 EAAVVLMEAA-----------------PELVNEpmtsdlyQGETALHIAVVNQNLNLVRELIARGADVVSpratgtffrp 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 929654355 130 -KDNELW---TPLHAAATCGHINLVKILVQYGADLLAVNSDGNMP 170
Cdd:cd22192  128 gPKNLIYygeHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTV 172
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 100-129 1.43e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.80  E-value: 1.43e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 929654355   100 DGLTALHQCCIDNFEEIVKLLLSHGANVNA 129
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 67-178 7.76e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 42.38  E-value: 7.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355   67 EASVALLEASLRndaEEVRYFLKNkvSPDLCNE-DGLTALHQCCIDNFEEIVKLLLSHGANVNAKDN------------- 132
Cdd:TIGR00870  98 EAILLHLLAAFR---KSGPLELAN--DQYTSEFtPGITALHLAAHRQNYEIVKLLLERGASVPARACgdffvksqgvdsf 172

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 929654355  133 ---ELwtPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEP 178
Cdd:TIGR00870 173 yhgES--PLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLLVMEN 219
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
71-321 6.99e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.55  E-value: 6.99e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  71 ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLV 150
Cdd:COG0666   57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 151 KILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETcmayqgitqekinemrvapeqqmiadihcMIAAGQDLDWIDAQGA 230
Cdd:COG0666  137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKL-----------------------------LLEAGADVNARDNDGE 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 231 TLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVL 310
Cdd:COG0666  188 TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALI 267

                        250
                 ....*....|.
gi 929654355 311 LLELKHKHDVI 321
Cdd:COG0666  268 VKLLLLALLLL 278
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
71-315 3.66e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 131.23  E-value: 3.66e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  71 ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLV 150
Cdd:COG0666   24 LLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 151 KILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETcmayqgitqekinemrvapeqqmiadihcMIAAGQDLDWIDAQGA 230
Cdd:COG0666  104 KLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKL-----------------------------LLEAGADVNAQDNDGN 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 231 TLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVL 310
Cdd:COG0666  155 TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEI 234


                 ....*
gi 929654355 311 LLELK 315
Cdd:COG0666  235 VKLLL 239
Ank_2 pfam12796
Ankyrin repeats (3 copies);
72-164 1.54e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 92.10  E-value: 1.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355   72 LLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHgANVNAKDNElWTPLHAAATCGHINLVK 151
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 929654355  152 ILVQYGADLLAVN 164
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 71-301 7.80e-18

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 86.23  E-value: 7.80e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  71 ALLEASLRNDAEEVRYFLKNKV---SPDLCnedGLTALHQC-CIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAAT--C 144
Cdd:PHA03095  53 LYLHYSSEKVKDIVRLLLEAGAdvnAPERC---GFTPLHLYlYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfN 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 145 GHINLVKILVQYGADLLAVNSDGNMPYD--LCEDEPTLDVIETCMAYQGITQEKINEMRVAPEQqmIAD--------IHC 214
Cdd:PHA03095 130 INPKVIRLLLRKGADVNALDLYGMTPLAvlLKSRNANVELLRLLIDAGADVYAVDDRFRSLLHH--HLQsfkprariVRE 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 215 MIAAGQDLDWIDAQGATLLHIAGANGYLRAAEL--LLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSART 292
Cdd:PHA03095 208 LIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287


                 ....*....
gi 929654355 293 SMDEMPIDL 301
Cdd:PHA03095 288 SDGNTPLSL 296
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 84-311 6.46e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 77.01  E-value: 6.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  84 VRYFLKNKVSPDLCNEDGLTALHQCCIDNFE-----EIVKLLLSHGANVNAKDNELWTPLHAAATC--GHINLVKILVQY 156
Cdd:PHA03100  51 VKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 157 GADLLAVNSDGNMP--YDLCEDEPTLDVIETcMAYQGItqeKINEM-RVapeqqmiadihcmiaagqdldwidaqgatll 233
Cdd:PHA03100 131 GANVNIKNSDGENLlhLYLESNKIDLKILKL-LIDKGV---DINAKnRV------------------------------- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 234 hiagangylraaELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMP----IDLCEEEEFKV 309
Cdd:PHA03100 176 ------------NYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPlhiaILNNNKEIFKL 243


                 ..
gi 929654355 310 LL 311
Cdd:PHA03100 244 LL 245
Ank_2 pfam12796
Ankyrin repeats (3 copies);
105-259 1.44e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.37  E-value: 1.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  105 LHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGadllavnsDGNMpydlcedeptldvie 184
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA--------DVNL--------------- 57

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 929654355  185 tcmayqgitqekinemrvapeqqmiadihcmiaagqdldwiDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKD 259
Cdd:pfam12796  58 -----------------------------------------KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 78-170 4.17e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 71.23  E-value: 4.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  78 RNDAEEVRYFLKNKVSPDLCNEDGLTALHQ----CCIDNfeEIVKLLLSHGANVNAKDN-EL---------------WTP 137
Cdd:PHA03100 118 SNSYSIVEYLLDNGANVNIKNSDGENLLHLylesNKIDL--KILKLLIDKGVDINAKNRvNYllsygvpinikdvygFTP 195

                         90       100       110
                 ....*....|....*....|....*....|...
gi 929654355 138 LHAAATCGHINLVKILVQYGADLLAVNSDGNMP 170
Cdd:PHA03100 196 LHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTP 228
Ank_2 pfam12796
Ankyrin repeats (3 copies);
212-291 1.97e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.21  E-value: 1.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  212 IHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHgVRVDVKDwDGWEPLHAAAFWGQMQMAELLVSHGASLSAR 291
Cdd:pfam12796  13 VKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADINVK 90
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 20-361 4.97e-12

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 68.74  E-value: 4.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  20 LERLRAAQKRRAQQLKKwaqyeQD--------LQHRKRKH-----ERKRSTGGRRKKVSFEASVaLLEASLRNDA--EEV 84
Cdd:PLN03192 471 LLRLKTSTLIEAMQTRQ-----EDnvvilknfLQHHKELHdlnvgDLLGDNGGEHDDPNMASNL-LTVASTGNAAllEEL 544

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  85 ryfLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGAdllavn 164
Cdd:PLN03192 545 ---LKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFAS------ 615

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 165 sdgnmpydlcedeptldvietcmayqgitqekinemrvapeqqmIADIHCmiaagqdldwidaqGATLLHIAGANGYLRA 244
Cdd:PLN03192 616 --------------------------------------------ISDPHA--------------AGDLLCTAAKRNDLTA 637

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 245 AELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEM-PIDLCEEEEFKvlllELKHKHDV--- 320
Cdd:PLN03192 638 MKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDDFsPTELRELLQKR----ELGHSITIvds 713

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 929654355 321 ---IMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRKE 361
Cdd:PLN03192 714 vpaDEPDLGRDGGSRPGRLQGTSSDNQCRPRVSIYKGHPLLRNE 757
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 70-287 5.51e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 67.71  E-value: 5.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  70 VALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINL 149
Cdd:PHA02875   4 VALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 150 VKILV---QYGADLLAvnSDGNMPYDLCEDEPTLDVIETCMAYqgitqekinemrvapeqqmiadihcmiaaGQDLDWID 226
Cdd:PHA02875  84 VEELLdlgKFADDVFY--KDGMTPLHLATILKKLDIMKLLIAR-----------------------------GADPDIPN 132

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 929654355 227 AQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGAS 287
Cdd:PHA02875 133 TDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGAN 193
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 109-300 7.79e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 67.30  E-value: 7.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 109 CIDNfeEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCM- 187
Cdd:PHA02874 101 CIEK--DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLe 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 188 --AYQGITQEKINE-MRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGAngYLRAAELLLDHGVRVDVKDWDGWE 264
Cdd:PHA02874 179 kgAYANVKDNNGESpLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGST 256

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 929654355 265 PLH-AAAFWGQMQMAELLVSHGASLSARTSMDEMPID 300
Cdd:PHA02874 257 PLHhAINPPCDIDIIDILLYHKADISIKDNKGENPID 293
Ank_4 pfam13637
Ankyrin repeats (many copies);
101-154 8.87e-12

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 59.98  E-value: 8.87e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 929654355  101 GLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILV 154
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 117-189 3.57e-11

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 66.07  E-value: 3.57e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654355 117 VKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAY 189
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 116-314 5.94e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 65.08  E-value: 5.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 116 IVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQG-ITQ 194
Cdd:PHA02876 160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSnINK 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 195 EKINEMRVAPEQQMIADIhCMIAAGQDLDWIDAQGATLLHIAGANGYL-RAAELLLDHGVRVDVKDWDGWEPLHAAAFWG 273
Cdd:PHA02876 240 NDLSLLKAIRNEDLETSL-LLYDAGFSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERGADVNAKNIKGETPLYLMAKNG 318

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 929654355 274 -QMQMAELLVSHGASLSARTSMDEMPI----DLCEEEEFKVLLLEL 314
Cdd:PHA02876 319 yDTENIRTLIMLGADVNAADRLYITPLhqasTLDRNKDIVITLLEL 364
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 112-323 5.38e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 61.52  E-value: 5.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 112 NFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSdgNMPYdlcedePTLDVIETcMAYQG 191
Cdd:PHA02874  13 DIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINT--KIPH------PLLTAIKI-GAHDI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 192 ITQEKIN--EMRVAP----EQQMIADIhcmIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEP 265
Cdd:PHA02874  84 IKLLIDNgvDTSILPipciEKDMIKTI---LDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYP 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 929654355 266 LHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI-DLCEEEEFKVLLLELKHKHDVIMK 323
Cdd:PHA02874 161 IHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLhNAAEYGDYACIKLLIDHGNHIMNK 219
Ank_2 pfam12796
Ankyrin repeats (3 copies);
233-284 8.16e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.89  E-value: 8.16e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 929654355  233 LHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSH 284
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH 52
PHA02798 PHA02798
ankyrin-like protein; Provisional
 115-267 8.39e-10

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 61.39  E-value: 8.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 115 EIVKLLLSHGANVNAKDNELWTPLHAAATC-----GHINLVKILVQYGADLLAVNSDGNMPydLCedeptldvietCMAY 189
Cdd:PHA02798  52 DIVKLFINLGANVNGLDNEYSTPLCTILSNikdykHMLDIVKILIENGADINKKNSDGETP--LY-----------CLLS 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 190 QGItqekINEMRVapeqqmiadIHCMIAAGQDLDWIDAQGATLLHI---AGANGYLRAAELLLDHGVRVDV-KDWDGWEP 265
Cdd:PHA02798 119 NGY----INNLEI---------LLFMIENGADTTLLDKDGFTMLQVylqSNHHIDIEIIKLLLEKGVDINThNNKEKYDT 185


                 ..
gi 929654355 266 LH 267
Cdd:PHA02798 186 LH 187
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 82-332 9.54e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 61.05  E-value: 9.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  82 EEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAatCGHIN------LVKILVQ 155
Cdd:PHA02878  18 KYIEYIDHTENYSTSASLIPFIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHII--CKEPNklgmkeMIRSINK 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 156 --YGADLLAVNSDGN---------MPYDLCEDEPTLDVIETC-MAYQGITQEKInemrvapeqqmiadIHCMIAAGQDLD 223
Cdd:PHA02878  96 csVFYTLVAIKDAFNnrnveifkiILTNRYKNIQTIDLVYIDkKSKDDIIEAEI--------------TKLLLSYGADIN 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 224 WIDA-QGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMP--ID 300
Cdd:PHA02878 162 MKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPlhIS 241

                        250       260       270
                 ....*....|....*....|....*....|..
gi 929654355 301 LCEEEEFKVLLLELKHKHDVIMKSQLRHKSSL 332
Cdd:PHA02878 242 VGYCKDYDILKLLLEHGVDVNAKSYILGLTAL 273
Ank_5 pfam13857
Ankyrin repeats (many copies);
120-174 1.49e-09

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 53.89  E-value: 1.49e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 929654355  120 LLSHG-ANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLC 174
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
231-282 2.63e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.05  E-value: 2.63e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 929654355  231 TLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLV 282
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 79-159 3.71e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 58.91  E-value: 3.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  79 NDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGA 158
Cdd:PHA03100 170 NAKNRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249


                 .
gi 929654355 159 D 159
Cdd:PHA03100 250 S 250
PHA03095 PHA03095
ankyrin-like protein; Provisional
 115-288 7.17e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 58.11  E-value: 7.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 115 EIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKI---LVQYGADLLAVNSDGNMPYDLC-EDEPTLDVIETcmayq 190
Cdd:PHA03095  28 EEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHLYlYNATTLDVIKL----- 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 191 gitqekinemrvapeqqmiadihcMIAAGQDLDWIDAQGATLLHI--AGANGYLRAAELLLDHGVRVDVKDWDGWEPLHA 268
Cdd:PHA03095 103 ------------------------LIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLRKGADVNALDLYGMTPLAV 158

                        170       180
                 ....*....|....*....|
gi 929654355 269 aafwgqmqmaeLLVSHGASL 288
Cdd:PHA03095 159 -----------LLKSRNANV 167
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 78-170 1.04e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.58  E-value: 1.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  78 RNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYG 157
Cdd:PHA02874 134 KGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHG 213

                         90
                 ....*....|...
gi 929654355 158 ADLLAVNSDGNMP 170
Cdd:PHA02874 214 NHIMNKCKNGFTP 226
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 71-201 1.74e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.52  E-value: 1.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  71 ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL----WTPLHAaatcgh 146
Cdd:PHA03100 195 PLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIETLlyfkDKDLNT------ 268

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 929654355 147 INLVKILVQYGADLLAVNSD--GNMPYdLCEDEPTLDVIETCmayqgitQEKINEMR 201
Cdd:PHA03100 269 ITKIKMLKKSIMYMFLLDPGfyKNRKL-IENSKSLKDVINEC-------EKEIERMK 317
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 80-288 2.62e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.53  E-value: 2.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  80 DAEEVRYFLKNKVSPDLCNEDGLTALHQC-CIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGA 158
Cdd:PHA02876 320 DTENIRTLIMLGADVNAADRLYITPLHQAsTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGA 399

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 159 DLLAVNSD--GNMPYDLCEDEPTLDVietcmayqgitqekinemrvapeqqmiadiHCMIAAGQDLDWIDAQGATLLHIA 236
Cdd:PHA02876 400 DIEALSQKigTALHFALCGTNPYMSV------------------------------KTLIDRGANVNSKNKDLSTPLHYA 449

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 929654355 237 -GANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAfwGQMQMAELLVSHGASL 288
Cdd:PHA02876 450 cKKNCKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGAEL 500
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 84-170 2.70e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 53.35  E-value: 2.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  84 VRYFLKNKVSPDLCNEDGLTALHQC---CIDnfEEIVKLLLSHGANVNAKDNEL-WTPLHAAATCGHInlVKILVQYGAD 159
Cdd:PHA02878 217 VHILLENGASTDARDKCGNTPLHISvgyCKD--YDILKLLLEHGVDVNAKSYILgLTALHSSIKSERK--LKLLLEYGAD 292

                         90
                 ....*....|.
gi 929654355 160 LLAVNSDGNMP 170
Cdd:PHA02878 293 INSLNSYKLTP 303
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 100-132 3.24e-07

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 46.51  E-value: 3.24e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 929654355  100 DGLTALHQCCID-NFEEIVKLLLSHGANVNAKDN 132
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
PHA03095 PHA03095
ankyrin-like protein; Provisional
 147-300 6.46e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.95  E-value: 6.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 147 INLVKILVQYGADllaVNSDGnmPYDLCedeptldVIETCMAYQGITQEKInemrvapeqqmiadIHCMIAAGQDLDWID 226
Cdd:PHA03095  27 VEEVRRLLAAGAD---VNFRG--EYGKT-------PLHLYLHYSSEKVKDI--------------VRLLLEAGADVNAPE 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 929654355 227 AQGATLLHIAGANGY-LRAAELLLDHGVRVDVKDWDGWEPLHA--AAFWGQMQMAELLVSHGASLSARTSMDEMPID 300
Cdd:PHA03095  81 RCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLRKGADVNALDLYGMTPLA 157
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 103-299 7.71e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.99  E-value: 7.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 103 TALHQCC-IDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGH-INLVKILVQYGADLLAVNSDGNMPYdlcEDEPTL 180
Cdd:PHA02876 275 TPLHHASqAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPL---HQASTL 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 181 D-----VIETCMAYQGITQEKINE---MRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIA--GANGYLrAAELLLD 250
Cdd:PHA02876 352 DrnkdiVITLLELGANVNARDYCDktpIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlcGTNPYM-SVKTLID 430

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 929654355 251 HGVRVDVKDWDGWEPLHAAAFWG-QMQMAELLVSHGASLSARTSMDEMPI 299
Cdd:PHA02876 431 RGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPL 480
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 212-297 1.48e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.05  E-value: 1.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 212 IHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGA---SL 288
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQchfEL 177


                 ....*....
gi 929654355 289 SARTSMDEM 297
Cdd:PTZ00322 178 GANAKPDSF 186
Ank_4 pfam13637
Ankyrin repeats (many copies);
71-121 3.43e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.19  E-value: 3.43e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 929654355   71 ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLL 121
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 67-170 3.47e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.01  E-value: 3.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  67 EASVALLEASlrndaeevryflknkvsPDLCNE-------DGLTALHQCCIDNFEEIVKLLLSHGANVNA---------- 129
Cdd:cd22192   65 EAAVVLMEAA-----------------PELVNEpmtsdlyQGETALHIAVVNQNLNLVRELIARGADVVSpratgtffrp 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 929654355 130 -KDNELW---TPLHAAATCGHINLVKILVQYGADLLAVNSDGNMP 170
Cdd:cd22192  128 gPKNLIYygeHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTV 172
PHA02946 PHA02946
ankyin-like protein; Provisional
 80-235 3.52e-06

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 49.67  E-value: 3.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  80 DAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGH--INLVKILVQYG 157
Cdd:PHA02946  51 DERFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYG 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 158 ADL-LAVNSDGNMPYDLCEDePTLDVIETCMA--YQGITQEKINEMRVapEQQMIAD------IHCMIAAGQDLDWIDAQ 228
Cdd:PHA02946 131 AKInNSVDEEGCGPLLACTD-PSERVFKKIMSigFEARIVDKFGKNHI--HRHLMSDnpkastISWMMKLGISPSKPDHD 207


                 ....*..
gi 929654355 229 GATLLHI 235
Cdd:PHA02946 208 GNTPLHI 214
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 75-212 4.91e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.22  E-value: 4.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  75 ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILV 154
Cdd:PHA02875 109 ATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLL 188

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 929654355 155 QYGADLLAVNSDGN---MPYDLCEDEPTL-----------DVIETCMAYQGITQEKINEMRVAPEQQ----MIADI 212
Cdd:PHA02875 189 DSGANIDYFGKNGCvaaLCYAIENNKIDIvrlfikrgadcNIMFMIEGEECTILDMICNMCTNLESEaidaLIADI 264
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 80-170 7.69e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 48.72  E-value: 7.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  80 DAEEVRYFLKNKVSPDLCNEDGL-TALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGA 158
Cdd:PHA02878 146 EAEITKLLLSYGADINMKDRHKGnTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225

                         90
                 ....*....|..
gi 929654355 159 DLLAVNSDGNMP 170
Cdd:PHA02878 226 STDARDKCGNTP 237
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 135-164 1.06e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 42.28  E-value: 1.06e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 929654355  135 WTPLHAAAT-CGHINLVKILVQYGADLLAVN 164
Cdd:pfam00023   3 NTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 100-129 1.43e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.80  E-value: 1.43e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 929654355   100 DGLTALHQCCIDNFEEIVKLLLSHGANVNA 129
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 135-160 2.70e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.03  E-value: 2.70e-05
                           10        20
                   ....*....|....*....|....*.
gi 929654355   135 WTPLHAAATCGHINLVKILVQYGADL 160
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADI 28
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
 80-170 2.86e-05

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 47.21  E-value: 2.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  80 DAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNF--EEIVKLLLSHGANVNAKDNELWTPLHA------------AATCG 145
Cdd:PHA02716 296 DISVVYSFLQPGVKLHYKDSAGRTCLHQYILRHNisTDIIKLLHEYGNDLNEPDNIGNTVLHTylsmlsvvnildPETDN 375

                         90       100
                 ....*....|....*....|....*..
gi 929654355 146 HINL--VKILVQYGADLLAVNSDGNMP 170
Cdd:PHA02716 376 DIRLdvIQCLISLGADITAVNCLGYTP 402
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 69-160 3.08e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 46.80  E-value: 3.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  69 SVALLEASLRNDAEEVRYFL---KNKVSPDLCNEdglTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLH-AAATC 144
Cdd:PHA02878 169 NTALHYATENKDQRLTELLLsygANVNIPDKTNN---SPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHiSVGYC 245

                         90
                 ....*....|....*.
gi 929654355 145 GHINLVKILVQYGADL 160
Cdd:PHA02878 246 KDYDILKLLLEHGVDV 261
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 232-316 3.33e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.82  E-value: 3.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 232 LLHIAgANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFK-VL 310
Cdd:PTZ00322  86 LCQLA-ASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFReVV 164


                 ....*.
gi 929654355 311 LLELKH 316
Cdd:PTZ00322 165 QLLSRH 170
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 100-129 3.53e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 40.70  E-value: 3.53e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 929654355  100 DGLTALHQCCIDNFEEIVKLLLSHGANVNA 129
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 37-283 3.72e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 46.54  E-value: 3.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  37 WAQY--EQDLQHRKRKHErkrstggrrkkvsfeasVALLEASLRNDAEEVRYFLKNKvSPDLCNEDGL--TALHQCCIDN 112
Cdd:cd22192    1 WAQMldELHLLQQKRISE-----------------SPLLLAAKENDVQAIKKLLKCP-SCDLFQRGALgeTALHVAALYD 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 113 FEEIVKLLLSHGAN-VN-AKDNELW---TPLHAAATCGHINLVKILVQYGADLLAVNSDGNM----PYDLCE-DEPTLdV 182
Cdd:cd22192   63 NLEAAVVLMEAAPElVNePMTSDLYqgeTALHIAVVNQNLNLVRELIARGADVVSPRATGTFfrpgPKNLIYyGEHPL-S 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 183 IETCMAYQGITQekinemrvapeqqmiadihCMIAAGQDLDWIDAQGATLLHI----AGANGYLRAAELLL-----DHGV 253
Cdd:cd22192  142 FAACVGNEEIVR-------------------LLIEHGADIRAQDSLGNTVLHIlvlqPNKTFACQMYDLILsydkeDDLQ 202

                        250       260       270
                 ....*....|....*....|....*....|.
gi 929654355 254 RVD-VKDWDGWEPLHAAAFWGQMQMAELLVS 283
Cdd:cd22192  203 PLDlVPNNQGLTPFKLAAKEGNIVMFQHLVQ 233
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 75-170 4.26e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.60  E-value: 4.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  75 ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALH-QCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAA--TCgHINLVK 151
Cdd:PHA02876 382 AAVRNNVVIINTLLDYGADIEALSQKIGTALHfALCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACkkNC-KLDVIE 460

                         90
                 ....*....|....*....
gi 929654355 152 ILVQYGADLLAVNSDGNMP 170
Cdd:PHA02876 461 MLLDNGADVNAINIQNQYP 479
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 242-397 1.66e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 44.67  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 242 LRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSA---------------------------RTSM 294
Cdd:PHA02876 158 LLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIialddlsvlecavdsknidtikaiidnRSNI 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 295 DEMPIDLC-----EEEEFKVLLLELK---HKHDVIMKSQLRHKS---SLSRRTSSAGSRGKVVRRASLSDRTNLY---RK 360
Cdd:PHA02876 238 NKNDLSLLkairnEDLETSLLLYDAGfsvNSIDDCKNTPLHHASqapSLSRLVPKLLERGADVNAKNIKGETPLYlmaKN 317

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 929654355 361 EYEGEAI--LWQRSAAEDQRTSTYNGDIRETRTDQENKD 397
Cdd:PHA02876 318 GYDTENIrtLIMLGADVNAADRLYITPLHQASTLDRNKD 356
Ank_4 pfam13637
Ankyrin repeats (many copies);
135-170 1.84e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 1.84e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 929654355  135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMP 170
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETA 37
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 135-162 2.00e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.78  E-value: 2.00e-04
                          10        20
                  ....*....|....*....|....*...
gi 929654355  135 WTPLHAAATCGHINLVKILVQYGADLLA 162
Cdd:pfam13606   3 NTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 75-290 3.82e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.51  E-value: 3.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  75 ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALhQCCID-NFEEIVKLLLSHGANVNAKDNELW------------------ 135
Cdd:PHA02876 185 AAERGNAKMVNLLLSYGADVNIIALDDLSVL-ECAVDsKNIDTIKAIIDNRSNINKNDLSLLkairnedletslllydag 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 136 -----------TPLHAAATCGHIN-LVKILVQYGADLLAVNSDGNMPYDLcedeptldvietcMAYQGITQEkinemrva 203
Cdd:PHA02876 264 fsvnsiddcknTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLYL-------------MAKNGYDTE-------- 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 204 peqqmiaDIHCMIAAGQDLDWIDAQGATLLHIAGA-NGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLV 282
Cdd:PHA02876 323 -------NIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLL 395


                 ....*...
gi 929654355 283 SHGASLSA 290
Cdd:PHA02876 396 DYGADIEA 403
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 78-171 4.87e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 41.73  E-value: 4.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355  78 RNDAEEVRYFLKnkvSPDLCNEDGLTALHQCCIDNF--EEIVKLLLSHGANVNAK--DNELwTPLHAAATCG---HINLV 150
Cdd:PHA02859  31 KDDIEGVKKWIK---FVNDCNDLYETPIFSCLEKDKvnVEILKFLIENGADVNFKtrDNNL-SALHHYLSFNknvEPEIL 106

                         90       100
                 ....*....|....*....|.
gi 929654355 151 KILVQYGADLLAVNSDGNMPY 171
Cdd:PHA02859 107 KILIDSGSSITEEDEDGKNLL 127
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 261-292 6.08e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 6.08e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 929654355  261 DGWEPLHAAA-FWGQMQMAELLVSHGASLSART 292
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Ank_5 pfam13857
Ankyrin repeats (many copies);
92-141 6.73e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.10  E-value: 6.73e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 929654355   92 VSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAA 141
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 67-178 7.76e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 42.38  E-value: 7.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355   67 EASVALLEASLRndaEEVRYFLKNkvSPDLCNE-DGLTALHQCCIDNFEEIVKLLLSHGANVNAKDN------------- 132
Cdd:TIGR00870  98 EAILLHLLAAFR---KSGPLELAN--DQYTSEFtPGITALHLAAHRQNYEIVKLLLERGASVPARACgdffvksqgvdsf 172

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 929654355  133 ---ELwtPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEP 178
Cdd:TIGR00870 173 yhgES--PLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLLVMEN 219
Ank_5 pfam13857
Ankyrin repeats (many copies);
215-269 1.29e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 1.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 929654355  215 MIAAGQ-DLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAA 269
Cdd:pfam13857   1 LLEHGPiDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 117-173 2.18e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 40.35  E-value: 2.18e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 929654355 117 VKLLLSHGANVNAKDNEL-WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDL 173
Cdd:PHA02884  86 AKLLIRYGADVNRYAEEAkITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIEL 143
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 228-259 3.05e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 3.05e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 929654355  228 QGATLLHIA-GANGYLRAAELLLDHGVRVDVKD 259
Cdd:pfam00023   1 DGNTPLHLAaGRRGNLEIVKLLLSKGADVNARD 33
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 114-206 3.10e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 39.42  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 114 EEIVKLLLSHGANVNAKDNELWTPLHAAAT-CG-HINLVKILVQYGADLLAVNSDGN---MPYDLCEDEptlDVIETCMA 188
Cdd:PHA02859 103 PEILKILIDSGSSITEEDEDGKNLLHMYMCnFNvRINVIKLLIDSGVSFLNKDFDNNnilYSYILFHSD---KKIFDFLT 179

                         90
                 ....*....|....*...
gi 929654355 189 YQGITQEKINEMRVAPEQ 206
Cdd:PHA02859 180 SLGIDINETNKSGYNCYD 197
PHA03095 PHA03095
ankyrin-like protein; Provisional
 216-320 3.52e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.01  E-value: 3.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654355 216 IAAGQDLDWIDAQGATLLHIAGANG---YLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQ-MQMAELLVSHGASLSAR 291
Cdd:PHA03095  34 LAAGADVNFRGEYGKTPLHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAK 113

                         90       100       110
                 ....*....|....*....|....*....|..
gi 929654355 292 TSMDEMPIDLC---EEEEFKVLLLELKHKHDV 320
Cdd:PHA03095 114 DKVGRTPLHVYlsgFNINPKVIRLLLRKGADV 145
Ank_5 pfam13857
Ankyrin repeats (many copies);
75-106 4.78e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.40  E-value: 4.78e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 929654355   75 ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALH 106
Cdd:pfam13857  23 AAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 261-290 4.78e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 4.78e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 929654355   261 DGWEPLHAAAFWGQMQMAELLVSHGASLSA 290
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH