|
Name |
Accession |
Description |
Interval |
E-value |
| PRK03633 |
PRK03633 |
putative MFS family transporter protein; Provisional |
1-381 |
0e+00 |
|
putative MFS family transporter protein; Provisional
Pssm-ID: 179614 [Multi-domain] Cd Length: 381 Bit Score: 671.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 1 MSTYTRPVMLLLCGLLLLTLAIAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLI 80
Cdd:PRK03633 1 MSTYTRPVLLLLCGLLLLTLAIAVLNTLVPLWLAQEHLPTWQVGVVSSSYFTGNLVGTLLAGYVIKRIGFNRSYYLASLI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 81 FAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGELLHV 160
Cdd:PRK03633 81 FAAGCAGLGLMVGFWSWLAWRFVAGIGCAMIWVVVESALMCSGTSRNRGRLLAAYMMVYYLGTVLGQLLVSKVSTELMSV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 161 LPWVTGMILAGILPLLFTRIVNQQTQARHSSSISAMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLKHQGMANASIGFW 240
Cdd:PRK03633 161 LPWVTGLVLAAILPLLFTRILNQQAENHDSTSIWPMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLNHQGMSDASIGFW 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 241 MAVLVSAGILGQWPMGRLADKFGRLLVLRVQVFVVILGSIAMLTQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLV 320
Cdd:PRK03633 241 MALLVSAGILGQWPIGRLADRFGRLLVLRVQVFVVILGSIAMLSQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHELV 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226710578 321 AMNQALLLSYTVGSLLGPSFAAMLMQNYSDNLLFIMIASVSFIYLLMLLRNAGQTPNPVAH 381
Cdd:PRK03633 321 AMNQALLLSYTVGSLLGPSFTAMLMQNYSDNLLFIMIASVSFIYLLMLLRKAGHTPTPVAH 381
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
21-368 |
4.35e-83 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 257.49 E-value: 4.35e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 21 AIAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSW 100
Cdd:cd17477 11 GSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 101 RFIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGELLHVLPWVTGMILAGILPLLFTRI 180
Cdd:cd17477 91 RFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 181 VnqQTQARHSSSISAMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLKHQGMANASIGFWMAVLVSAGILGQWPMGRLAD 260
Cdd:cd17477 171 A--APEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLAD 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 261 KFGRLLVLRVQVFVVILGSIAML----TQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLL 336
Cdd:cd17477 249 RFDRRRVLLGCALLGALAALLLPlvpgLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVI 328
|
330 340 350
....*....|....*....|....*....|..
gi 226710578 337 GPSFAAMLMQNYSDNLLFIMIASVSFIYLLML 368
Cdd:cd17477 329 GPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
21-334 |
1.54e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 111.22 E-value: 1.54e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 21 AIAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSW 100
Cdd:COG2814 25 GIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 101 RFIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLvskvSGELLHVLPWVTGMILAGILPLL---- 176
Cdd:COG2814 105 RFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLL----GGLLADLFGWRWVFLVNAVLALLalll 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 177 ---FTRIVNQQTQARHSSSISAMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLKHQ-GMANASIGFWMAVLVSAGILGQ 252
Cdd:COG2814 181 llrLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGA 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 253 WPMGRLADKFGRLLVLRVQVFVVILGSIAML---TQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLS 329
Cdd:COG2814 261 LLAGRLADRFGRRRLLLIGLLLLALGLLLLAlagSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
....*
gi 226710578 330 YTVGS 334
Cdd:COG2814 341 FFLGG 345
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
21-368 |
4.29e-22 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 96.46 E-value: 4.29e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 21 AIAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSW 100
Cdd:COG0738 23 ATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 101 RFIAGIGCAMIWVVVeSALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVS-----KVSGELLHVLPWVTGMILAGILPL 175
Cdd:COG0738 103 LFLLGLGLGLLDVAA-NPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGllillGLSLSWHLPYLILAVLLLLLALLF 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 176 LFTRI----VNQQTQARHSSSISAMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLKHQ-GMANASIGFWMAVLVSAGIL 250
Cdd:COG0738 182 LRSKLpeieEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVlGLSEATAALGLSLFWGGMTI 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 251 GQWPMGRLADKFGRLLVLRVQVFVVILGSIAMLTQAAMAPALFILGAAGF---TLYPVAMAWACEKVEHHQLVAMNQALL 327
Cdd:COG0738 262 GRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLglsLMFPTIFSLALDGLGKRTAAAVSAVLI 341
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 226710578 328 LSYtVGSLLGPSFAAMLMQNYSDNLLFIMIAsVSFIYLLML 368
Cdd:COG0738 342 MGI-VGGAIGPPLIGFLADAFGLRAAFLVPL-VCYLLILLL 380
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
21-369 |
4.26e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 93.65 E-value: 4.26e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 21 AIAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSW 100
Cdd:cd06174 11 ARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 101 RFIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGELLHVLPWVTGMILAGILPLLFT-- 178
Cdd:cd06174 91 RFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILll 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 179 --------RIVNQQTQARHSSSISAMLKLRQARLGVNGCIISGIVLGSLYGLMPLY----LKHQGMANASIGFWMAVLVS 246
Cdd:cd06174 171 lvvpdppeSARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLplflLDLGGLSVAVAGLLLSLFGL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 247 AGILGQWPMGRLADK-FGRLLVLRVQVFVVILGSIAML---TQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAM 322
Cdd:cd06174 251 AGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLlapSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTA 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 226710578 323 NQALLLSYTVGSLLGPSFAAML-MQNYSDNLLFIMIASVSFIYLLMLL 369
Cdd:cd06174 331 FGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
22-370 |
3.68e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 90.71 E-value: 3.68e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 22 IAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWR 101
Cdd:cd17325 12 YGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 102 FIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGELLHVLPWVTGMILAGILPLLFTRIV 181
Cdd:cd17325 92 FLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 182 ---------NQQTQARHSSSISAMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLKHQGMANAS-IGFWMAVLVSAGILG 251
Cdd:cd17325 172 peprpppnkRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAqIGLLFGAQGLASALS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 252 QWPMGRLADKFGRLLVLRVQVFVVILGSIAML---TQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLL 328
Cdd:cd17325 252 QPPAGKLSDRIGRKPLILIGLLLSAVALLLLPlatSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNT 331
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 226710578 329 SYTVGSLLGPSFAAMLMQNYSDNLLFIMIASVSFIYLLMLLR 370
Cdd:cd17325 332 AFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
21-338 |
8.97e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 77.46 E-value: 8.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 21 AIAVLNTLVPLWLAQA-NLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMS 99
Cdd:pfam07690 11 GRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 100 WRFIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLvskvSGELLHVLPWVTGMILAGILPLLFT- 178
Cdd:pfam07690 91 LRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLL----GGLLASLFGWRAAFLILAILSLLAAv 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 179 ------------RIVNQQTQARHSSSISAMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLKHQGMANASIGFWMAVLVS 246
Cdd:pfam07690 167 llllprpppeskRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 247 AGILGQWPMGRLADKFGRLLVLRVQVFVVILGSIAML------TQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLV 320
Cdd:pfam07690 247 LGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLllsltlSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERG 326
|
330
....*....|....*...
gi 226710578 321 AMNQALLLSYTVGSLLGP 338
Cdd:pfam07690 327 TASGLYNTAGSLGGALGP 344
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
21-369 |
1.74e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 76.86 E-value: 1.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 21 AIAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSW 100
Cdd:cd17489 11 SFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 101 RFIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYY----MGTFLGQLLVSKVSGELLHVLPWVTGMILAGILPLL 176
Cdd:cd17489 91 RLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTlamaLGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 177 FTRIVNQQTQARHSSSISAMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLKHQGMANAsiGFWMAVLVSAGILGQWPMG 256
Cdd:cd17489 171 KDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNA--GLFFTVYAIALLLSRPFSG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 257 RLADKFGRLLVLRVQVFVVILGsIAMLTQAAMAPALFILGA---AGF-TLYPVAMAWACEKVEHHQLVAMNQALLLSYTV 332
Cdd:cd17489 249 KLSDRKGPKTVIIPGLLLLALG-LLLLSFAGSPWMLLLAAVlygLGFgLLFPALQALAVDLVPPHRRGAANGTFFIFFDL 327
|
330 340 350
....*....|....*....|....*....|....*..
gi 226710578 333 GSLLGPSFAAMLMQNYSDNLLFIMIASVSFIYLLMLL 369
Cdd:cd17489 328 GIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
23-370 |
2.81e-15 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 76.45 E-value: 2.81e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 23 AVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRF 102
Cdd:COG2271 27 SNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 103 IAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMmvyyMGTFLGQLLVSKVSGELLHVLPWVTGMILAGILPLLFTRIvn 182
Cdd:COG2271 107 LLGLGEAGFFPAALKLIAEWFPPKERGRALGIFN----AGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL-- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 183 qqtqarhsssisamlklrQARLGVNGCIISGIVLGSLYGLMPLYLK-HQGMANASIGFWMAVLVSAGILGQWPMGRLADK 261
Cdd:COG2271 181 ------------------RFWLLALAYFLVYFALYGFLTWLPTYLVeVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 262 FGRLLVlRVQVFVVILGSIAML------TQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSL 335
Cdd:COG2271 243 LGRRRK-LVLAIGLLLAALALLllallpSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGA 321
|
330 340 350
....*....|....*....|....*....|....*
gi 226710578 336 LGPSFAAMLMQNYSDNLLFIMIASVSFIYLLMLLR 370
Cdd:COG2271 322 LGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
37-366 |
5.97e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 72.20 E-value: 5.97e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 37 NLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVE 116
Cdd:cd17324 30 GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 117 SALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGEL-LHVLPWVTGMILAGILPLLFTRI-VNQQTQARHSSSIS 194
Cdd:cd17324 110 AYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLgWRAAFLAIAVLALLAALLLWRLLpSLPPKKPGSLGLLS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 195 AMLKLRQARLGVNGCIISGIVLGSLYGL---MPLYLKHQ-GMANASIGFWMAVLVSAGILGQWPMGRLADKFGRLLVLRV 270
Cdd:cd17324 190 SLLLLLRNPRLRLAYLITFLLFGGFFALytyLAPFLTDVpGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIA 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 271 QVFVVILGSIAMLT---QAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNqALLLSYTVGSLLGPSFAAMLMQN 347
Cdd:cd17324 270 LLLLAAALLLLTLLgpsPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASS-LYLAAYNLGGALGAALGGLVLDH 348
|
330
....*....|....*....
gi 226710578 348 YSDNLLFIMIASVSFIYLL 366
Cdd:cd17324 349 GGWAGVGWVGAALLLLALL 367
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
42-300 |
1.24e-13 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 71.45 E-value: 1.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 42 QVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVESALMC 121
Cdd:COG2223 41 QLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 122 SGTSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGEL-LHVLPWVTGMILAGILPLLFTRIVN-----QQTQARHSSSISA 195
Cdd:COG2223 121 WFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFgWRNAFLILGILLLVVAVLAWLFLRDppagaAAAAKASLRDQLE 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 196 MLKLRQARLGVNGCIISGIVLGSLYGLMPLYLKHQ-GMANASIGFWMAVLVSAGILGQWPMGRLADKFGRLLVLRVqVFV 274
Cdd:COG2223 201 ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLI-VFA 279
|
250 260
....*....|....*....|....*.
gi 226710578 275 VILGSIAMLTQAAMAPALFILGAAGF 300
Cdd:COG2223 280 LMALGLLLLALALGSLWLFLVLFLLL 305
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
35-370 |
1.41e-13 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 71.49 E-value: 1.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 35 QANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVV 114
Cdd:cd17329 29 QLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 115 VESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVS---KVSGELLHVLPWVTGMILAGILPLLFTRIVNQQTQARHSS 191
Cdd:cd17329 109 SEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGlllLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 192 SISAMLKLRQARLGVNGCIISGI---VLGSLYGLMPLYLKHQGMANAS-IGFWMAVLVSAGILGQWPMGRLADKFGRLLV 267
Cdd:cd17329 189 ILRGYKIVLRDRAFLLFLLASFLislIYFQLESTLPVYVVEILGLGESlLGLLLALNALLIVLLQFPVARLVERFRLRKI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 268 LRVQVFVVILGsiAMLTQAAMAPALFILGAAGFTL-----YPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLLGPSFAA 342
Cdd:cd17329 269 LMIGILLFAIG--FAVLAFANTLAVLILAMIVLTLgemlvFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGG 346
|
330 340
....*....|....*....|....*...
gi 226710578 343 MLMQNYSDNLLFIMIASVSFIYLLMLLR 370
Cdd:cd17329 347 LLLDLLGPGLPWLILAALGLIAAALLLG 374
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
21-370 |
2.47e-13 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 70.67 E-value: 2.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 21 AIAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSW 100
Cdd:COG2807 33 AITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAG 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 101 RFIAGIGCAMIWVVVESALMcSGTSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGELLHVLPWVTGMILAGILPLLFTRI 180
Cdd:COG2807 113 TALIGAGIAVGNVLLPGLIK-RWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 181 VNQQTQARHSSSISAMLK-LRQARLGVNGCIISGIVLGSLYGL---MPLYLKHQGMANASIGFWMAVLVSAGILGQWPMG 256
Cdd:COG2807 192 LRRRPAAAAAAPAAASLRsLWRSPLAWLLTLFFGLQSLLYYAVvawLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVP 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 257 RLADKFGRLLVLRVQVFVVILGSIAML---TQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLS-YTV 332
Cdd:COG2807 272 LLADRLGDRRPLLLLLGLLGLAGLLGLllaPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSvGYL 351
|
330 340 350
....*....|....*....|....*....|....*....
gi 226710578 333 GSLLGPSFAAMLMQNYSD-NLLFIMIASVSFIYLLMLLR 370
Cdd:COG2807 352 LAALGPLLVGALHDATGSwTAALLLLAALAVLMLVAGLL 390
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
37-369 |
2.89e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 64.16 E-value: 2.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 37 NLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVE 116
Cdd:cd17316 32 GLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 117 SALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGELLHVLPW----VTGMILAGILPLLFTRIVnqqtqarhsss 192
Cdd:cd17316 112 TYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWrilfLIGALPALLALLLRRRTL----------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 193 isamlklrqarLGVNGCIISGIVLGSLYGLMPLYLKH-QGMANASIGFWMAVLVSAGILGQWPMGRLADKFGRLLVLRV- 270
Cdd:cd17316 181 -----------LLILLWFFISFGYYGLTTFLPTYLQTvLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIg 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 271 ----QVFVVILGSIAMLTQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQ-LVAMNQALLLSYTVGSLLGPSFAAMLM 345
Cdd:cd17316 250 lilsGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVrATGVGLSYNLGRLGGGGAPPLIALLLA 329
|
330 340
....*....|....*....|....
gi 226710578 346 QNYSDNLLFIMIASVSFIYLLMLL 369
Cdd:cd17316 330 STGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
23-310 |
6.17e-11 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 63.34 E-value: 6.17e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 23 AVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRF 102
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 103 IAGIGCAMIWVvvESALMCSGTS-HNRGRLLAAYMMVYYMGTFLGQLLVSKV--SGELLHVLPWVTGMILAGILPLLFTR 179
Cdd:cd17478 93 LAGIGSAAFHP--EGARLASQAAgGRRGLAMSIFSVGGNLGFALGPLIAAALvaLFGGLGLLILLIIPGLAVALLLLRLR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 180 IVNQQTQARHSSSISAMLKLRQARLGVN----GCIISGIVLGSLYGLMPLYLKHQGMANASIGFWMAVLVSAGILGQWPM 255
Cdd:cd17478 171 PLKKPEAKKAAAKSSARSTLKGVWRALLllliIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIG 250
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 226710578 256 GRLADKFGRLLVLRVQVFVVILGSIAML--TQAAMAPALFILGAAGFTLYPVAMAWA 310
Cdd:cd17478 251 GPLSDRFGRRRVIIASLLLAAPFLLLFLltPGIWSYILLVLAGFLLFASFPVTVVLA 307
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
24-264 |
2.12e-09 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 58.47 E-value: 2.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 24 VLNTLVPLWlaqaNLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFI 103
Cdd:cd17371 21 VLPALIAEF----GLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 104 AGIGCAMIWVVVeSALM--CSGTSHnRGRLLAAYMMVYYMGTFLGQLLVSKVSGELLHVLPWvTGMILAGILPLLFTRIV 181
Cdd:cd17371 97 AGLGFGGEWAAG-AALMaeYVPARH-RGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAW-RVLFLLGALPALLVLFI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 182 N---------QQTQARHSS-----SISAMLKLRQARLGVNGCIISGIVLGSLYGL---MPLYLK-HQGMANASIGFWMAV 243
Cdd:cd17371 174 RrfvkeppqwQAARAARRHfadrpSLRELFSPPLLRTTLLASLLATGALGGYYGIttwLPSYLTgERGLSFEGSAGYLVV 253
|
250 260
....*....|....*....|.
gi 226710578 244 LVSAGILGQWPMGRLADKFGR 264
Cdd:cd17371 254 TILGGFLGYLAGGFLADRIGR 274
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
22-349 |
2.30e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 58.36 E-value: 2.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 22 IAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWR 101
Cdd:cd17503 12 TTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 102 FIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLvskvSGELLHVLPW--------VTGMILAGIL 173
Cdd:cd17503 92 ILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTL----GGWLTDNLSWrwifyinlPIGILALLLA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 174 PLLFTRIvnqqtqarhsssisamLKLRQARLGVNGCIISGIVLGSLYGLMPLYLkhQGMANAS---IGFWMAVLVSAGIL 250
Cdd:cd17503 168 PLLDLRL----------------FKDRNFTLGLLLSFLLGLGLFGAMFLLPLYL--QNVLGYSafeSGLVLAPGGLASAI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 251 GQWPMGRLADKFG-RLLVLrvQVFVVILGSIAMLTQ-------AAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAM 322
Cdd:cd17503 230 LSPLVGRLLDKFGpRLLLL--AGLLLLALGTLLLAFltpdtslWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDA 307
|
330 340
....*....|....*....|....*..
gi 226710578 323 NQALLLSYTVGSLLGPSFAAMLMQNYS 349
Cdd:cd17503 308 TALFNTIRQLGGSIGTALLATLLTNRT 334
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
6-178 |
2.97e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.97 E-value: 2.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 6 RPVMLLLCGLLLLTLAIAVLNTLVPLWLAQ-ANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAG 84
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPLYAAElGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 85 CVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLvskvSGELLHVLPWV 164
Cdd:cd17325 279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL----GGFLYDAFGFA 354
|
170
....*....|....
gi 226710578 165 TGMILAGILPLLFT 178
Cdd:cd17325 355 TPFLAAAALLLLAA 368
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
37-370 |
8.04e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.81 E-value: 8.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 37 NLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVE 116
Cdd:cd17474 30 GASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 117 SALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLL---VSKVSGELLHVLPWVTgmILAGILPLLFTRIVNQQTQARHSSSI 193
Cdd:cd17474 110 TLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLgglLAAISWRYPFFLLAAL--IPVAFLAILFLLPEPKEKAKSSSATK 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 194 SAMLKLRQARLGVNGCIISGIVLGSLYGL----MPLYLKHQGMANAS-IGFWMAVLVSAGILGQWPMGRLADKFGRLLVL 268
Cdd:cd17474 188 LRDLKKALRGRGLLTFLVSAFLYFFLYFAfltyLPFLLELLYGISPIiIGLLFAGWSVLLALGSLFVGRLLKKRFGARRI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 269 RVQVFVVILGSIAML----TQAAMAPALFILGAA---GFTLYPVAMAWACEKVEHHQLVAMNQALLlsyTVGSLLGPSFA 341
Cdd:cd17474 268 LVIGLLLYALSLLLLgfvpSLALLLIAIVLFGLGlglNLPLLTTLVTELAPEEERGTASSLYNFVR---FLGQAVGPLLF 344
|
330 340
....*....|....*....|....*....
gi 226710578 342 AMLMQNYSDNLLFIMIASVSFIYLLMLLR 370
Cdd:cd17474 345 GLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
22-293 |
1.93e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 55.20 E-value: 1.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 22 IAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWR 101
Cdd:COG0477 30 FTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAAR 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 102 FIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLlvskVSGELLHVLPWVTGMILAGILPLLFTRIV 181
Cdd:COG0477 110 ALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPL----LGGLLVAALGWRWIFLINAPLGLLALVLR 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 182 NQQTQARhsSSISAMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLKHQGMANASIGFWMAVLVSAGILGQWPMGRLADK 261
Cdd:COG0477 186 LRLPESR--GLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALL 263
|
250 260 270
....*....|....*....|....*....|..
gi 226710578 262 FGRLLVLRVQVFVVILGSIAMLTQAAMAPALF 293
Cdd:COG0477 264 LLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
28-361 |
2.55e-08 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 55.00 E-value: 2.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 28 LVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIG 107
Cdd:cd06180 21 LLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 108 CAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGELLHvlpWVTGMILAGILPLLFTRIVnqQTQA 187
Cdd:cd06180 101 SAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGLS---WRAGWLALALLSAVLLLLS--FLLL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 188 RHSSSISAMLKLRQARLGVNGCIISGIVLGSLYGL--------MPLYLKHQGMANASIGFWMAVLVSAGILGQWPMGRLA 259
Cdd:cd06180 176 RRGPSAPTEASAAESAPGLNRPLWRLALAYGLFGFgyiitatfLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALS 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 260 DKFGRLLVLRVQVFVVILGSIAMLTQAamAPALFILGAAGFTLYPVA-----MAWACEKVEHHQLVAMNqALLLSYTVGS 334
Cdd:cd06180 256 DRWGTRRALAANLLVQAVGVLLPLLSP--GPAGLVLSAVLFGGTFMAitalvMALARELAPPAAPRALA-LMTASFGVGQ 332
|
330 340
....*....|....*....|....*..
gi 226710578 335 LLGPSFAAMLMQNYSDNLLFIMIASVS 361
Cdd:cd06180 333 ILGPLLAGWLADATGGFAPALILAAAA 359
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
22-300 |
4.02e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 54.67 E-value: 4.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 22 IAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWR 101
Cdd:TIGR00895 33 LAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILR 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 102 FIAGIGCAMIWVVVeSALMCSGTSHNRGRLLAAYMMV-YYMGTFLGQLLvskvSGELLHVLPWVTGMILAGILPLLF--- 177
Cdd:TIGR00895 113 FLAGLGLGGLMPNL-NALVSEYAPKRFRGTAVGLMFCgYPIGAAVGGFL----AGWLIPVFGWRSLFYVGGIAPLLLlll 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 178 --------------------TRIVNQQTQARHSSSISAMLKLRQA---RLGVNGCIISGIV--------------LGSLY 220
Cdd:TIGR00895 188 lmrflpesidflvskrpetvRRIVNAIAPQMQAEAQSALPEQKSTqgtKRSVFKALFQGKTaritvllwllyfmlLVGVY 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 221 GL---MPLYLKHQGMANASIGFWMAVLVSAGILGQWPMGRLADKFGRLLVLRVQVFVVILGSIAMLTQAAMAPALFILGA 297
Cdd:TIGR00895 268 FLtnwLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAI 347
|
...
gi 226710578 298 AGF 300
Cdd:TIGR00895 348 AGF 350
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
5-178 |
6.97e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.77 E-value: 6.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 5 TRPVMLLLCGLLLLTLAIAVLNTLVPLWLAQA-NLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAA 83
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVlGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 84 GCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVskvsGELLHVLPW 163
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLA----GLLADALGL 362
|
170
....*....|....*
gi 226710578 164 VTGMILAGILPLLFT 178
Cdd:cd06173 363 SAVFLLAGALLLLAA 377
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
42-370 |
1.04e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 53.35 E-value: 1.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 42 QVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVESALMC 121
Cdd:cd17320 35 AVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 122 SGTSHNRGRLLAAYMMVYYMGTFLGQLLvskvSGELLHVLPW---------VTGMILAGILPLLFTRIVNQQTQARHSSS 192
Cdd:cd17320 115 LYSGAELAKIFSLLMMILAIAPALAPLL----GGLLLLFFGWraifvflalLGLLLLLLVLLFLPETLPEEKRKPLLSSL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 193 ISAMLKLRQARLGVNGCIISGIVLGSLYGLMP----LYLKHQGMANASIGFWMAVLVSAGILGQWPMGRLADKFGRLLVL 268
Cdd:cd17320 191 LRAYKRVLKNRRFLGYALALGLSFAGLFAYLAaapfIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 269 RVQVFVVILGSIAMLTQAA---------MAPALFILGAAGFtLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLLGpS 339
Cdd:cd17320 271 RLGLLLLLAAALVLLLAALlgglslwplVAPLFLIFFGFGL-IFPNATSLALEPFPHVAGTASALLGFLQFLIGALAG-A 348
|
330 340 350
....*....|....*....|....*....|.
gi 226710578 340 FAAMLMQNYSDNLLFIMIASVSFIYLLMLLR 370
Cdd:cd17320 349 LVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
22-298 |
1.41e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 52.97 E-value: 1.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 22 IAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWR 101
Cdd:cd17365 15 LAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 102 FIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVSKvsgeLLHVLPWVTGMILAGILPLLFTRIV 181
Cdd:cd17365 95 FLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAA----LIPAFGWRSVFLLGGVPPLILLPLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 182 nqqtqarhsssisamlklrqaRLGVNGCIISGIVLGSLYGL---MPLYLKHQGMANASIGFWMAVLVSAGILGQWPMGRL 258
Cdd:cd17365 171 ---------------------RGTLLLWVTFFMGLLLVYLLnswLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWL 229
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 226710578 259 ADKFGRLLVLRVQVFVVILGSIAMLTQAAMAPALFILGAA 298
Cdd:cd17365 230 ADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFL 269
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
42-370 |
1.44e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 52.96 E-value: 1.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 42 QVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVESALMC 121
Cdd:cd17319 39 QYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 122 SGTSHNRGRLLAAYMmvyyMGTFLGQLLVSKVSGELLHVLPWVTGMILAGILPLLFTrivnqqtqarhsssISAMLKLRQ 201
Cdd:cd17319 119 WFPARERGRATGLFN----SGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLA--------------VLWWFYLRQ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 202 ARLGVNGCIISGIVLGSLYGLMPLYLKHQ-GMANASIGFWMAVLVSAGILGQWPMGRLADKF-----GRLLVLRVQVFVV 275
Cdd:cd17319 181 VWGLALGYFGINYALYGLLTWLPTYLKQArGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgarRLVIIIGLLLAAV 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 276 ILGSIAMLTQAAMAPALFILGAAG-FTLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLLGPSFAAMLMQ-NYSDNLL 353
Cdd:cd17319 261 GLLLAYLTTSPVVAVILLSLAGFGiGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDaTGSYTAA 340
|
330
....*....|....*..
gi 226710578 354 FIMIASVSFIYLLMLLR 370
Cdd:cd17319 341 FLFLAAVALLAALLVLL 357
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
208-370 |
4.50e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.13 E-value: 4.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 208 GCIISGIVLGSLYGLMPLYLKHQGMANASIGFWMAVLVSAGILGQWPMGRLADKFGRLLVLRVQVFVVILGSIAML---T 284
Cdd:COG2814 18 GAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAlapS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 285 QAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLLGPSFAAMLMQNYSDNLLFIMIASVSFIY 364
Cdd:COG2814 98 LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLA 177
|
....*.
gi 226710578 365 LLMLLR 370
Cdd:COG2814 178 LLLLLR 183
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
42-297 |
9.13e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 50.25 E-value: 9.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 42 QVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVESALMC 121
Cdd:cd17321 32 QLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 122 SGTSHNRGRLLAAYMMVYYMGTFLGQLLvskvSGELLHVLPWvtGMILAGILPLlftrivnqqtqarhssSISAMLKLRQ 201
Cdd:cd17321 112 TFPGERRGRALGLWGAVVGIGAALGPLL----GGLLLELFGW--RWIFLINVPI----------------GLVALLLART 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 202 ARLGVNGCIISGIVLGSLYGLMPLYLKH-QGMANASIGFWMAVLVSAGILGQWPMGRLADKFGRLLVLRVQVFVVILGSI 280
Cdd:cd17321 170 FSGAVLAAFLLGAALGGLLFLLPLYLQGvLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLL 249
|
250 260
....*....|....*....|...
gi 226710578 281 AML------TQAAMAPALFILGA 297
Cdd:cd17321 250 LLAllgadsSVWLLLPGLVLLGL 272
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
21-323 |
1.15e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 50.01 E-value: 1.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 21 AIAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSW 100
Cdd:cd17333 11 TDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 101 RFIAGIgCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVSK-VSGELLHVLPWVTGMILAGILPLLFTR 179
Cdd:cd17333 91 MFLAGL-GAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSlLTSELSWSWAYLIIGLIYLLLAILILL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 180 I---------VNQQTQARHSSSISAMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLKH-QGMANASIGFWMAVLVSAGI 249
Cdd:cd17333 170 TlfpelpsarNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEkKHVSDGLAGYLLSGFWVGIT 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226710578 250 LGQWPMGRLADKFGRLLVLRVQVFVVILGSIAML---TQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMN 323
Cdd:cd17333 250 IGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLlapTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTS 326
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
211-370 |
1.73e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 49.50 E-value: 1.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 211 ISGIVLGSLYGLMPLYLKHQGMANASIGFWMAVLVSAGILGQWPMGRLADKFGRLLVLRVQVFVVILGSIAML---TQAA 287
Cdd:cd17325 7 LDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAfatSYWQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 288 MAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLLGPSFAAMLMQNYSDNLLFIMIASVSFIYLLM 367
Cdd:cd17325 87 LLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVL 166
|
...
gi 226710578 368 LLR 370
Cdd:cd17325 167 ALL 169
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
41-114 |
4.19e-06 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 47.96 E-value: 4.19e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226710578 41 WQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVV 114
Cdd:cd17317 25 WLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTV 98
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
122-302 |
4.40e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.36 E-value: 4.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 122 SGTSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGELLHVLPW---VTGMILAGILPLLFT--------RIVNQQTQARHS 190
Cdd:COG2211 139 TPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALgyrLTALIFAVLGLLAFLltffgtkeRPVPEEEKVSLK 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 191 SSISAMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLKHQ-GMANASIGFWMAVLVSAGILGQWPMGRLADKFGRLLVLR 269
Cdd:COG2211 219 ESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFI 298
|
170 180 190
....*....|....*....|....*....|...
gi 226710578 270 VQVFVVILGSIAMLTQAAMAPALFILGAAGFTL 302
Cdd:COG2211 299 IGLLLAALGLLLLFFLGPGNLWLLLVLAALAGI 331
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
210-370 |
1.14e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.03 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 210 IISGIVLGSLYGLMPLYLKHQ-GMANASIGFWMAVLVSAGILGQWPMGRLADKFGRLLVLRVQVFVVILGSIAML---TQ 285
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLfasSL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 286 AAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLLGPSFAAMLMQNYSDNLLFIMIASVSFIYL 365
Cdd:pfam07690 86 WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAA 165
|
....*
gi 226710578 366 LMLLR 370
Cdd:pfam07690 166 VLLLL 170
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
22-148 |
2.20e-05 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 46.02 E-value: 2.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 22 IAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWR 101
Cdd:cd17359 17 TGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIAR 96
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 226710578 102 FIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQL 148
Cdd:cd17359 97 IIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYI 143
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
28-344 |
2.41e-05 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 45.82 E-value: 2.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 28 LVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCV--GLGVMVGFWSWMSWRFIAG 105
Cdd:pfam06779 15 ILPVMIAEGQFSLSQAGLLAAANYAGYLAGALLASFAWRHGASRLRPALLAGLLATVLLllAMAATSSFWAVLLIRFLAG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 106 IGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGELLHVLPWVTGMILAGILPLLFTRIVNQQT 185
Cdd:pfam06779 95 VASAAVMIFGSSLILGHATAARRAFVGALLFAGVGIGIALSGLLVPLGLQLGLGGSSLWYGAGVLSAVLTLAVFPLLPRR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 186 QARHSSSISAMLKLRQARLGVngciisgIVLGSLYGL-----------MPLYLKHQ-GMANASIGFWMAVLVSAgILGQW 253
Cdd:pfam06779 175 APRHASAPAPAAKPLQRSLPL-------WILTLAYGLagfgyiitatfLPAMARDGfGGPAAAALFWSLFGLAA-ALGVL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 254 PMGRLADKFGRLLVLRVQVFVVILGsiAMLTQAAMAPALFILGAAGFTLY-----PVAMAWACEKVEHHQLVAMNQaLLL 328
Cdd:pfam06779 247 VWLRAAKRWGTRPALTAALLIQALG--VLLSLLSPSPAGLAVSSLLFGGTfmaitSLVMQLARELAPPAPRRLLGL-MTA 323
|
330
....*....|....*.
gi 226710578 329 SYTVGSLLGPSFAAML 344
Cdd:pfam06779 324 SFGIGQILGPLLASLL 339
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
44-300 |
5.00e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 44.87 E-value: 5.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 44 GMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVESALMCSG 123
Cdd:cd17315 37 GLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 124 TSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGELLHVLPWvtgMILAGILPLLFTRIVNQQTQARHSSSISAMLKLRQAR 203
Cdd:cd17315 117 PAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWRL---MFALAAVPALLQLLLMFFLPESRALLVGVGLQLLQQL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 204 LGVNGCI-ISGIVLGSLYGLMPLYLkhqgmANASIGFWM--AVLVSAgilgqwpmgRLADKFGRLLVLRVQVFVVILG-- 278
Cdd:cd17315 194 TGINAVMyYAPTIFKSAGGGTASIL-----ASIIVGVVNllATLVAI---------RLVDKVGRRPLLLIGFAGMAASll 259
|
250 260
....*....|....*....|....*.
gi 226710578 279 ----SIAMLTQAAMAPALFILGAAGF 300
Cdd:cd17315 260 llaiAFLLPALAKAAGWLALLGILLY 285
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
41-370 |
6.82e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.57 E-value: 6.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 41 WQVGMVSSSYFTGNLVGTL---FTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWM-SWRFIAGIGCAMIWVVVE 116
Cdd:cd17355 35 WSRAVISLAFTVGLLAFGLaqpFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYlLWGLLGGGGAGTLAAVAF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 117 SALMCSGTSHNRGRLLAaymmVYYMGTFLGQLLVSKVSGELLHVLPWVTGMILAGILPLLFT----------------RI 180
Cdd:cd17355 115 ATVAAWWFERRRGLALG----ILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLvpvllllrrrpadlalRA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 181 VNQQTQARHSSSISAMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLKHQGMANASIGFWMAVLVSAGILGQWPMGRLAD 260
Cdd:cd17355 191 YDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGD 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 261 KFGRLLVLRVQVFVVILGSIAML----TQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLL 336
Cdd:cd17355 271 RYSPRRLLAASYALRALGLALLLllpfPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSAL 350
|
330 340 350
....*....|....*....|....*....|....*
gi 226710578 337 GP-SFAAMLMQNYSDNLLFIMIASVSFIYLLMLLR 370
Cdd:cd17355 351 GPwLGGLLYDRTGSYTAAWALAVALGLIAALLVLP 385
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
21-366 |
9.41e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 44.11 E-value: 9.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 21 AIAVLNTLVPLWLAQANLPTWQVG-MVSSSYFTGnLVGTLFTGYLIKRIGFNRSYYLASLIFAA--GCVGLGVMVGFWSW 97
Cdd:cd17335 12 ALGSLLPFLSVYLKQLGLSPTQIGiLIGIRPFVR-FLSAPLWGALADRFGKRKALLLLSLLAAVlfFLSLFFVAQIFWLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 98 MSWRFIAGIGCAMIWVVVESALMCSGTSHN----RGRLLAAYMMVyyMGTFLGQLLVSKVSGELLHVLPWVTGMILAGIL 173
Cdd:cd17335 91 LLLVILGAFFSAPVVPLVDSITLQYLGEERerygKQRLWGSIGFG--IAALLVGILIDRSSTYKNYTIAFYVFAVLMLLA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 174 PLLFTRIVNQQTQARHSSSISAMLKL---RQARLGVNGCIISGIVLGSLYGLMPLYLKHQGMANASIGFWMAVLVSAGIL 250
Cdd:cd17335 169 LLLALKFPFRPKHPEPNENTGGLLALlrnPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSKTLIGLLWTVGVVSEIP 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 251 GQWPMGRLADKFG--RLLVLRVQVFVVILGSIAMLTQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALL- 327
Cdd:cd17335 249 FFFFSSRLIQRFGhvGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATAQGLLq 328
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 226710578 328 -LSYTVGSLLGPSFAAMLMQNYSDNLLFIMIASVSFIYLL 366
Cdd:cd17335 329 gLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLL 368
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
42-150 |
1.16e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 43.72 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 42 QVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVESALMC 121
Cdd:cd17473 234 LIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMS 313
|
90 100
....*....|....*....|....*....
gi 226710578 122 SGTSHNRGRLLAAYMMVYYMGTFLGQLLV 150
Cdd:cd17473 314 LVPPELRGRAMGIVTSAFFLGQFLSPLVL 342
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
41-115 |
2.06e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 43.08 E-value: 2.06e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226710578 41 WQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVV 115
Cdd:TIGR00898 127 WKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQA 201
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
5-146 |
2.29e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.79 E-value: 2.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 5 TRPVMLLLCGLLLLTLAIAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAG 84
Cdd:pfam07690 199 RDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA 278
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 226710578 85 CVGLGVMVGFWSWMSWR---FIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLG 146
Cdd:pfam07690 279 ALGLLLLSLTLSSLWLLlalLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
42-173 |
7.10e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 41.49 E-value: 7.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 42 QVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWmsW-----RFIAGIGCAMIWVVVE 116
Cdd:pfam00083 47 LSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSV--YqlivgRVLVGIGVGGASVLAP 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 117 SALMCSGTSHNRGRLLAAYMMVYYMGTFLGQ---LLVSKVSGELLHVLPWVTGMILAGIL 173
Cdd:pfam00083 125 MYISEIAPKKLRGALGSLYQLAITFGILLAYifgLGLNKTSNSDGWRIPLGLQLVPALLL 184
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
38-180 |
7.11e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.40 E-value: 7.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 38 LPTWQVGMVSSSYFTGNLVGTLFTGYLI-KRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVE 116
Cdd:cd17474 231 ISPIIIGLLFAGWSVLLALGSLFVGRLLkKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLT 310
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226710578 117 SALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGELLHVLPWVTGMILAGILPLLFTRI 180
Cdd:cd17474 311 TLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
6-158 |
9.02e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.04 E-value: 9.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 6 RPVMLLLCGLLLLTLAIAVLNTLVPLWLAQA-NLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAG 84
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226710578 85 CVGLGVMVG--FWSWMSWRFIAGIGCAMIWVVVESALMCS---GTSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGELL 158
Cdd:COG2211 308 LLLLFFLGPgnLWLLLVLAALAGIGLGAILVLPWAMLADVvdyDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLL 386
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
27-318 |
9.39e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.07 E-value: 9.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 27 TLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGI 106
Cdd:cd17475 17 ALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 107 GCAMIWVVVESALMCSGTSHNRGrlLAayMMVYYMGTFLGQLLVSKVSGELLHVLPWVTGMILAGILPLLFTRIV----- 181
Cdd:cd17475 97 GYGSVQPGGGRAIMRWFPPRERG--LA--MGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFwlfyr 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 182 NQQTQARHSSSISAMLKLRQARLG----VNGCIISGIVLGSLYGL---MPLYLK-HQGMANASIGFWMAVLVSAGILGQW 253
Cdd:cd17475 173 EPPAASAATESASTLLRSLKEVLRnrdvWLIAIAGALLVAPQFALltfLLLFLHdHLGLSVVAAGALLAVAQLGGALGRI 252
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226710578 254 PMGRLADKFG---RLLVLRVQVFVVILGSIAML------TQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQ 318
Cdd:cd17475 253 GLGRVSDRVFggrRRPVLVITAAIAAAALLVLSllspgtPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQ 326
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
29-370 |
1.30e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.67 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 29 VPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFA-AGCVGLGVMVGFWSWMSWRFIAGIG 107
Cdd:cd17490 19 LSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTvLASLIMILFPSPWGLLIARFLSGIA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 108 CAMiWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGEL-LHVLPWVTgmILAGILPLLFTRIVNQQTQ 186
Cdd:cd17490 99 AAT-WVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFgMRAPFLLA--ALAGVLGFILSLFIKEERR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 187 ARHS--SSISAMLK-LRQARL---GVNGCIISGIVLGSLYGLMPLYLKHQGMANASIGFWMAVLVSAGILGqwpmGRLA- 259
Cdd:cd17490 176 EKKPvlTELKELLSvLKDKKLlffSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALA----SLLSg 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 260 DKFGRLLVLRVQVFVVILGSIAMLTQAAMAPALFIL-------GAAGFTLYPVAMAWACEKV-EHHQLVAMN--QALlls 329
Cdd:cd17490 252 TLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLyllqalnGFGTGILFPLLMSLSIEGVpAEQRSTAMGffQAI--- 328
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 226710578 330 YTVGSLLGPSFAAMLMQNYSDNLLFIMIASVSFIYLLMLLR 370
Cdd:cd17490 329 YALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLA 369
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-176 |
1.36e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 40.24 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 21 AIAVLNTLVPLWLAQA-NLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLA--SLIFAAGCVGLGVMVGFWSW 97
Cdd:COG2271 195 ALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAigLLLAALALLLLALLPSPALA 274
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226710578 98 MSWRFIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVskvsGELLHVLPWVTGMILAGILPLL 176
Cdd:COG2271 275 IALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLV----GYLLDATGYQAAFLLLAALALL 349
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
209-369 |
1.38e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 40.29 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 209 CIISGIVLGSLYGLMPLYLKHQGMANASIGfwMAVLVSAGILGQWPMGRLADKFGRLLVLRVqVFVVILGSIAMLTQAAM 288
Cdd:cd17353 225 NATAGLMLIGQAKPIGQEFAGLDAGIAALA--VSILSIFNGGGRPFWGWLSDKIGRKNTLSI-AFLIQGVAMFLLPFIGS 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 289 APALFILGAA--------GFTLYPVAMAwacEKVEHHQLVAMNQALLLSYTVGSLLGPSFAAMLMQNYSDNLLFIMIASV 360
Cdd:cd17353 302 VAVLFVLGVAligfcyggGFALFPALTA---DFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAAL 378
|
....*....
gi 226710578 361 SFIYLLMLL 369
Cdd:cd17353 379 SLVALALAL 387
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
223-370 |
1.58e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.27 E-value: 1.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 223 MPLYLKHQGMANASIGFWMAVLVSAGILGQWPMGRLADKFGRLLVLRVQVFVVILGSIAMLTQAAMAP---ALFILGAAG 299
Cdd:cd17489 19 LPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALllvLRLIHGIGW 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226710578 300 FTLYPVAMAWACEKV-EHHQLVAMNqALLLSYTVGSLLGPSFAAMLMQNYSDNLLFIMIASVSFIYLLMLLR 370
Cdd:cd17489 99 GAFTTAAATLVADIIpPSRRGEGIG-YYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFL 169
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
21-115 |
1.75e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 40.28 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 21 AIAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVG--FWSWM 98
Cdd:cd17332 236 AFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPgnLVLIL 315
|
90
....*....|....*..
gi 226710578 99 SWRFIAGIGCAMIWVVV 115
Cdd:cd17332 316 VLAVLAGIGYGGANLLP 332
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
39-314 |
5.11e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 38.71 E-value: 5.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 39 PTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVESA 118
Cdd:cd17473 33 SELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 119 LMCSGTSHNRGRLLAAYMMVYYMG----TFLGQLLVSK--VSGELLHVLPWVtgmILAGILPLLFTRIVNQQTQARHSSS 192
Cdd:cd17473 113 IGDYFEGEERAKMLGLQSAAMSLGgvvfLLLGGALAEIgwRAPFLVYLLALP---VLILVLLFLPEPARKSKSAASPGAA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 193 ISAMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLKHQGMANAS-IGFWMAVLVSAGILGQWPMGRLADKFGRLLVLRVQ 271
Cdd:cd17473 190 TAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAAlIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIG 269
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 226710578 272 VFVVILGSIAM---LTQAAMAPALFILGAAGFTLYPVAMAWACEKV 314
Cdd:cd17473 270 FALMALGFLLLalaSGLWVVLLGAILAGLGFGLLLPTLNSWAMSLV 315
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
37-145 |
5.45e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 38.41 E-value: 5.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 37 NLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVE 116
Cdd:cd17360 31 VLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVP 110
|
90 100
....*....|....*....|....*....
gi 226710578 117 SALMCSGTSHNRGRLLAAYMMVYYMGTFL 145
Cdd:cd17360 111 LYIAEAAPPRIRGRLVTINVLFITGGQFV 139
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
48-178 |
6.38e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 38.33 E-value: 6.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710578 48 SSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVESALMCSGTSHN 127
Cdd:cd17323 41 SLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEE 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 226710578 128 RGRllaaYMMVYYMGTFLGQLLVSKVSGELLHVLPW----VTGMILAGILPLLFT 178
Cdd:cd17323 121 RGK----AMGVYSLGPLLGPALGPIIGGFITQSLGWrwifWFLAIISGFCLILIF 171
|
|
| |
