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Conserved domains on  [gi|1492128172|sp|B0R0D7|]
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RecName: Full=Coronin-1C-A

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-471 3.17e-106

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 324.54  E-value: 3.17e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172   9 SKFRHVFGQAVKNDQCYDDIRVSRVTWD-SAFCAVNPKFVALIVEASGGGAfmVLPLHKTGRIDKAYPTVCGHTGPVLDI 87
Cdd:PTZ00421    4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172  88 DWCPHNDQVIASGSEDCTVMVWQIPENGLVTSMSEPVVVLEGHSKRVGVVTWHPTARNVLLSAGCDNMIIIWNVGTGESM 167
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 168 ITLEDhHPDIIYSICWNRNGSLICTACKDKKIRVIDPRKEEIIAEKDkAHEGARPMRAIFLSDGK-VFTTGFSRMSERQL 246
Cdd:PTZ00421  162 EVIKC-HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 247 ALWDPENIDEPVAVHEMDTSNGVLLPFYDPDTNVVYLCGKGDSSIRYFEITDEAPFVHYlnTFTTKEPQRGMGYMPKRGL 326
Cdd:PTZ00421  240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 327 DVNKCEIARFYKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTAGPDAPLEAEEWFEGKNGDPVLISLkHGYIPGKNRDL- 403
Cdd:PTZ00421  318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM-SAVFDGTSPELm 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 404 KVVKKNilDNKMSKNTENTTPAHKTATSTPS----------------IKSEAKLEEVLKEIKSLRELVSSQEKRIGKLEE 467
Cdd:PTZ00421  397 GASALS--PSGKPRHSGVSVPASTSAMTHSFddntskhadpcamgvkRMDEGILDERLGRLQALSEKLRTQHEEIKRCRE 474


                  ....
gi 1492128172 468 QLSK 471
Cdd:PTZ00421  475 ALQK 478
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-471 3.17e-106

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 324.54  E-value: 3.17e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172   9 SKFRHVFGQAVKNDQCYDDIRVSRVTWD-SAFCAVNPKFVALIVEASGGGAfmVLPLHKTGRIDKAYPTVCGHTGPVLDI 87
Cdd:PTZ00421    4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172  88 DWCPHNDQVIASGSEDCTVMVWQIPENGLVTSMSEPVVVLEGHSKRVGVVTWHPTARNVLLSAGCDNMIIIWNVGTGESM 167
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 168 ITLEDhHPDIIYSICWNRNGSLICTACKDKKIRVIDPRKEEIIAEKDkAHEGARPMRAIFLSDGK-VFTTGFSRMSERQL 246
Cdd:PTZ00421  162 EVIKC-HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 247 ALWDPENIDEPVAVHEMDTSNGVLLPFYDPDTNVVYLCGKGDSSIRYFEITDEAPFVHYlnTFTTKEPQRGMGYMPKRGL 326
Cdd:PTZ00421  240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 327 DVNKCEIARFYKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTAGPDAPLEAEEWFEGKNGDPVLISLkHGYIPGKNRDL- 403
Cdd:PTZ00421  318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM-SAVFDGTSPELm 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 404 KVVKKNilDNKMSKNTENTTPAHKTATSTPS----------------IKSEAKLEEVLKEIKSLRELVSSQEKRIGKLEE 467
Cdd:PTZ00421  397 GASALS--PSGKPRHSGVSVPASTSAMTHSFddntskhadpcamgvkRMDEGILDERLGRLQALSEKLRTQHEEIKRCRE 474


                  ....
gi 1492128172 468 QLSK 471
Cdd:PTZ00421  475 ALQK 478
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 1.11e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 126.46  E-value: 1.11e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1492128172   4 RVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSAFCAVNPKFVALIVEASGGGAFMVLPLHKTGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 76-301 1.97e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.19  E-value: 1.97e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172  76 TVCGHTGPVLDIDWCPHNDQvIASGSEDCTVMVWQIpenglvtSMSEPVVVLEGHSKRVGVVTWHPTARnVLLSAGCDNM 155
Cdd:cd00200    46 TLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDL-------ETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 156 IIIWNVGTGESMITLEDhHPDIIYSICWNRNGSLICTACKDKKIRVIDPRKEEIIAEKdKAHEGarPMRAI-FLSDGKVF 234
Cdd:cd00200   117 IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL-TGHTG--EVNSVaFSPDGEKL 192

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 235 TTGFsrmSERQLALWDPENiDEPVAV---HEmDTSNGVLlpfYDPDTNVVyLCGKGDSSIRYFEITDEAP 301
Cdd:cd00200   193 LSSS---SDGTIKLWDLST-GKCLGTlrgHE-NGVNSVA---FSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
76-253 3.99e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 3.99e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172  76 TVCGHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENglvtsmsEPVVVLEGHSKRVGVVTWHPTARnVLLSAGCDNM 155
Cdd:COG2319   199 TLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATG-------KLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGT 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 156 IIIWNVGTGESMITLeDHHPDIIYSICWNRNGSLICTACKDKKIRVIDPRKEEIIAEkDKAHEGARpmRAI-FLSDGKVF 234
Cdd:COG2319   270 VRLWDLATGELLRTL-TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTGAV--RSVaFSPDGKTL 345

                         170
                  ....*....|....*....
gi 1492128172 235 TTGFsrmSERQLALWDPEN 253
Cdd:COG2319   346 ASGS---DDGTVRLWDLAT 361
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 79-109 9.02e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 9.02e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1492128172   79 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVW 109
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-471 3.17e-106

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 324.54  E-value: 3.17e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172   9 SKFRHVFGQAVKNDQCYDDIRVSRVTWD-SAFCAVNPKFVALIVEASGGGAfmVLPLHKTGRIDKAYPTVCGHTGPVLDI 87
Cdd:PTZ00421    4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172  88 DWCPHNDQVIASGSEDCTVMVWQIPENGLVTSMSEPVVVLEGHSKRVGVVTWHPTARNVLLSAGCDNMIIIWNVGTGESM 167
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 168 ITLEDhHPDIIYSICWNRNGSLICTACKDKKIRVIDPRKEEIIAEKDkAHEGARPMRAIFLSDGK-VFTTGFSRMSERQL 246
Cdd:PTZ00421  162 EVIKC-HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 247 ALWDPENIDEPVAVHEMDTSNGVLLPFYDPDTNVVYLCGKGDSSIRYFEITDEAPFVHYlnTFTTKEPQRGMGYMPKRGL 326
Cdd:PTZ00421  240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 327 DVNKCEIARFYKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTAGPDAPLEAEEWFEGKNGDPVLISLkHGYIPGKNRDL- 403
Cdd:PTZ00421  318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM-SAVFDGTSPELm 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 404 KVVKKNilDNKMSKNTENTTPAHKTATSTPS----------------IKSEAKLEEVLKEIKSLRELVSSQEKRIGKLEE 467
Cdd:PTZ00421  397 GASALS--PSGKPRHSGVSVPASTSAMTHSFddntskhadpcamgvkRMDEGILDERLGRLQALSEKLRTQHEEIKRCRE 474


                  ....
gi 1492128172 468 QLSK 471
Cdd:PTZ00421  475 ALQK 478
PTZ00420 PTZ00420
coronin; Provisional
 25-460 2.56e-70

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 233.69  E-value: 2.56e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172  25 YDDIRV-SRVTwDSAFCAVNPKFVALIVEASGGGAFMVLPLHKTGRidkaYPTVC---GHTGPVLDIDWCPHNDQVIASG 100
Cdd:PTZ00420   19 FDDLRIcSRVI-DSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR----KPPVIklkGHTSSILDLQFNPCFSEILASG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 101 SEDCTVMVWQIPENG-LVTSMSEPVVVLEGHSKRVGVVTWHPTARNVLLSAGCDNMIIIWNVGTGESmiTLEDHHPDIIY 179
Cdd:PTZ00420   94 SEDLTIRVWEIPHNDeSVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKR--AFQINMPKKLS 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 180 SICWNRNGSLICTACKDKKIRVIDPRKEEIiAEKDKAHEGARPMRAIFL-----SDGKVFTTGFSRMSERQLALWDPENI 254
Cdd:PTZ00420  172 SLKWNIKGNLLSGTCVGKHMHIIDPRKQEI-ASSFHIHDGGKNTKNIWIdglggDDNYILSTGFSKNNMREMKLWDLKNT 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 255 DEPVAVHEMDTSNGVLLPFYDPDTNVVYLCGKGDSSIRYFEITDEApfVHYLNTFTTKEPQRGMGYMPKRGLDVNKCEIA 334
Cdd:PTZ00420  251 TSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDVYKCEIG 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 335 RFYK-LHERKCEPIIMTVPRK-SDLFQDDLYPDTAGPDAPLEAEEWFEGKNGDPVLISLKHgyipGKNRDLKVVKKNILD 412
Cdd:PTZ00420  329 RVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKD----LTEDDLRITKKYKFV 404

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1492128172 413 NKMSK-------NTENTTPAHKTATSTPSIKSEAKLEEVLKEIKSLRELVSSQEK 460
Cdd:PTZ00420  405 PQSFNsiiigenYTSKRTSIIRQFTKKFTFFKKGEHNDGFSSVDSFKESVFIYPK 459
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 1.11e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 126.46  E-value: 1.11e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1492128172   4 RVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSAFCAVNPKFVALIVEASGGGAFMVLPLHKTGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 76-301 1.97e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.19  E-value: 1.97e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172  76 TVCGHTGPVLDIDWCPHNDQvIASGSEDCTVMVWQIpenglvtSMSEPVVVLEGHSKRVGVVTWHPTARnVLLSAGCDNM 155
Cdd:cd00200    46 TLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDL-------ETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 156 IIIWNVGTGESMITLEDhHPDIIYSICWNRNGSLICTACKDKKIRVIDPRKEEIIAEKdKAHEGarPMRAI-FLSDGKVF 234
Cdd:cd00200   117 IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL-TGHTG--EVNSVaFSPDGEKL 192

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 235 TTGFsrmSERQLALWDPENiDEPVAV---HEmDTSNGVLlpfYDPDTNVVyLCGKGDSSIRYFEITDEAP 301
Cdd:cd00200   193 LSSS---SDGTIKLWDLST-GKCLGTlrgHE-NGVNSVA---FSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-300 1.09e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.57  E-value: 1.09e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172  79 GHTGPVLDIDWCPHNDqVIASGSEDCTVMVWQIPENGLVTSmsepvvvLEGHSKRVGVVTWHPtARNVLLSAGCDNMIII 158
Cdd:cd00200     7 GHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGELLRT-------LKGHTGPVRDVAASA-DGTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 159 WNVGTGESMITLEdHHPDIIYSICWNRNGSLICTACKDKKIRVIDPRKEEIIAEKdKAHEGarPMRAIFLSDGKVFTTGF 238
Cdd:cd00200    78 WDLETGECVRTLT-GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL-RGHTD--WVNSVAFSPDGTFVASS 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1492128172 239 SRmsERQLALWDPENIdEPVAVHEMDTSNGVLLPFyDPDTNVVYLCGkGDSSIRYFEITDEA 300
Cdd:cd00200   154 SQ--DGTIKLWDLRTG-KCVATLTGHTGEVNSVAF-SPDGEKLLSSS-SDGTIKLWDLSTGK 210
WD40 COG2319
WD40 repeat [General function prediction only];
76-253 3.99e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 3.99e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172  76 TVCGHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENglvtsmsEPVVVLEGHSKRVGVVTWHPTARnVLLSAGCDNM 155
Cdd:COG2319   199 TLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATG-------KLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGT 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 156 IIIWNVGTGESMITLeDHHPDIIYSICWNRNGSLICTACKDKKIRVIDPRKEEIIAEkDKAHEGARpmRAI-FLSDGKVF 234
Cdd:COG2319   270 VRLWDLATGELLRTL-TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTGAV--RSVaFSPDGKTL 345

                         170
                  ....*....|....*....
gi 1492128172 235 TTGFsrmSERQLALWDPEN 253
Cdd:COG2319   346 ASGS---DDGTVRLWDLAT 361
WD40 COG2319
WD40 repeat [General function prediction only];
79-253 2.51e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 2.51e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172  79 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENglvtsmsEPVVVLEGHSKRVGVVTWHPTARnVLLSAGCDNMIII 158
Cdd:COG2319   244 GHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATG-------ELLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRL 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 159 WNVGTGESMITLEDHHpDIIYSICWNRNGSLICTACKDKKIRVIDPRKEEIIAEKdKAHEGArPMRAIFLSDGKVFTTGf 238
Cdd:COG2319   315 WDLATGKLLRTLTGHT-GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-TGHTGA-VTSVAFSPDGRTLASG- 390

                         170
                  ....*....|....*
gi 1492128172 239 SRmsERQLALWDPEN 253
Cdd:COG2319   391 SA--DGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
79-252 4.18e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.76  E-value: 4.18e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172  79 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIpENGlvtsmsEPVVVLEGHSKRVGVVTWHPTARnVLLSAGCDNMIII 158
Cdd:COG2319   118 GHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL-ATG------KLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 159 WNVGTGESMITLEDhHPDIIYSICWNRNGSLICTACKDKKIRVIDPRKEEIIAEKDkaHEGARPMRAIFLSDGKVFTTGf 238
Cdd:COG2319   189 WDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSPDGRLLASG- 264

                         170
                  ....*....|....
gi 1492128172 239 srMSERQLALWDPE 252
Cdd:COG2319   265 --SADGTVRLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-237 2.06e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 2.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172  79 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENGLVTsmsepvvVLEGHSKRVGVVTWHPTARNvLLSAGCDNMIII 158
Cdd:cd00200   133 GHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVA-------TLTGHTGEVNSVAFSPDGEK-LLSSSSDGTIKL 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 159 WNVGTGESMITLEDHhPDIIYSICWNRNGSLICTACKDKKIRVIDPRKEEIIAEKdKAHEGarPMRAIFLS-DGKVFTTG 237
Cdd:cd00200   204 WDLSTGKCLGTLRGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL-SGHTN--SVTSLAWSpDGKRLASG 279
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 344-386 2.76e-20

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 83.72  E-value: 2.76e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1492128172 344 CEPIIMTVPRKS-DLFQDDLYPDTAGPDAPLEAEEWFEGKNGDP 386
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-201 2.34e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.16  E-value: 2.34e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172  79 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIpenglvtSMSEPVVVLEGHSKRVGVVTWHPTaRNVLLSAGCDNMIII 158
Cdd:cd00200   175 GHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDL-------STGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRV 245

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1492128172 159 WNVGTGESMITLEdHHPDIIYSICWNRNGSLICTACKDKKIRV 201
Cdd:cd00200   246 WDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 126-292 2.75e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.14  E-value: 2.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 126 VLEGHSKRVGVVTWHPTaRNVLLSAGCDNMIIIWNVGTGESMITLEDHHpDIIYSICWNRNGSLICTACKDKKIRVIDPR 205
Cdd:cd00200     4 TLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHT-GPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 206 KEEIIAEKdKAHEGarPMRAI-FLSDGKVFTTGfsrMSERQLALWDPENiDEPVAV---HEMDTSNGVllpfYDPDTNVV 281
Cdd:cd00200    82 TGECVRTL-TGHTS--YVSSVaFSPDGRILSSS---SRDKTIKVWDVET-GKCLTTlrgHTDWVNSVA----FSPDGTFV 150

                         170
                  ....*....|.
gi 1492128172 282 YlCGKGDSSIR 292
Cdd:cd00200   151 A-SSSQDGTIK 160
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-160 1.93e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 1.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172  79 GHTGPVLDIDWCPHNDqVIASGSEDCTVMVWQIpENGlvtsmsEPVVVLEGHSKRVGVVTWHPTArNVLLSAGCDNMIII 158
Cdd:cd00200   217 GHENGVNSVAFSPDGY-LLASGSEDGTIRVWDL-RTG------ECVQTLSGHTNSVTSLAWSPDG-KRLASGSADGTIRI 287


                  ..
gi 1492128172 159 WN 160
Cdd:cd00200   288 WD 289
WD40 COG2319
WD40 repeat [General function prediction only];
79-253 1.83e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 1.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172  79 GHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLVTsmsepvvvLEGHSKRVGVVTWHPTARnVLLSAGCDNMIII 158
Cdd:COG2319    34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAT--------LLGHTAAVLSVAFSPDGR-LLASASADGTVRL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172 159 WNVGTGESMITLEdHHPDIIYSICWNRNGSLICTACKDKKIRVIDPRKEEIIAEKdKAHEGArpMRAI-FLSDGKVFTTG 237
Cdd:COG2319   105 WDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGA--VTSVaFSPDGKLLASG 180

                         170
                  ....*....|....*.
gi 1492128172 238 FsrmSERQLALWDPEN 253
Cdd:COG2319   181 S---DDGTVRLWDLAT 193
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 79-109 9.02e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 9.02e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1492128172   79 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVW 109
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
76-109 5.57e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 5.57e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1492128172  76 TVCGHTGPVLDIDWCPhNDQVIASGSEDCTVMVW 109
Cdd:pfam00400   6 TLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 163-203 1.80e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.80e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1492128172  163 TGESMITLEdHHPDIIYSICWNRNGSLICTACKDKKIRVID 203
Cdd:smart00320   1 SGELLKTLK-GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 122-160 5.68e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 5.68e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1492128172  122 EPVVVLEGHSKRVGVVTWHPTaRNVLLSAGCDNMIIIWN 160
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
121-160 2.52e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.52e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1492128172 121 SEPVVVLEGHSKRVGVVTWHPTaRNVLLSAGCDNMIIIWN 160
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
164-203 3.35e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.35e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1492128172 164 GESMITLEdHHPDIIYSICWNRNGSLICTACKDKKIRVID 203
Cdd:pfam00400   1 GKLLKTLE-GHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 66-110 3.51e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 3.51e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1492128172  66 KTGRIDKaypTVCGHTGPVLDIDWCPHNdQVIASGSEDCTVMVWQ 110
Cdd:cd00200   249 RTGECVQ---TLSGHTNSVTSLAWSPDG-KRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 66-171 1.15e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.61  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172  66 KTGRiDKAYPTV-CGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLVTSMSEpvvvlegHSKRVGVVTWHPTAR 144
Cdd:PLN00181  517 KDGR-DIHYPVVeLASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKE-------HEKRVWSIDYSSADP 588

                          90       100
                  ....*....|....*....|....*..
gi 1492128172 145 NVLLSAGCDNMIIIWNVGTGESMITLE 171
Cdd:PLN00181  589 TLLASGSDDGSVKLWSINQGVSIGTIK 615
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 89-186 7.38e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.72  E-value: 7.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492128172  89 WCPHNDqVIASGSEDCTV--------MVWQIP---ENGLVTSMSepvvvleghskrvgvvtWHPTARnVLLSAGCDNMII 157
Cdd:pfam12894   3 WCPTMD-LIALATEDGELllhrlnwqRVWTLSpdkEDLEVTSLA-----------------WRPDGK-LLAVGYSDGTVR 63

                          90       100
                  ....*....|....*....|....*....
gi 1492128172 158 IWNVGTGESMITLEDHHPDIIySICWNRN 186
Cdd:pfam12894  64 LLDAENGKIVHHFSAGSDLIT-CLGWGEN 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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