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Conserved domains on  [gi|1512483039|gb|AYV87258|]
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dual oxidase 2, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
An_peroxidase_like super family cl14561
Animal heme peroxidases and related proteins; A diverse family of enzymes, which includes ...
1-49 5.25e-21

Animal heme peroxidases and related proteins; A diverse family of enzymes, which includes prostaglandin G/H synthase, thyroid peroxidase, myeloperoxidase, linoleate diol synthase, lactoperoxidase, peroxinectin, peroxidasin, and others. Despite its name, this family is not restricted to metazoans: members are found in fungi, plants, and bacteria as well.


The actual alignment was detected with superfamily member cd09820:

Pssm-ID: 353811 [Multi-domain]  Cd Length: 558  Bit Score: 83.50  E-value: 5.25e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1512483039   1 YWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNP 49
Cdd:cd09820   373 YLFGPLEFSRRDLMALNIQRGRDHGLPDYNTAREAFGLPPRTTWSDINP 421
 
Name Accession Description Interval E-value
dual_peroxidase_like cd09820
Dual oxidase and related animal heme peroxidases; Animal heme peroxidases of the dual-oxidase ...
1-49 5.25e-21

Dual oxidase and related animal heme peroxidases; Animal heme peroxidases of the dual-oxidase like subfamily play vital roles in the innate mucosal immunity of gut epithelia. They provide reactive oxygen species which help control infection.


Pssm-ID: 188652 [Multi-domain]  Cd Length: 558  Bit Score: 83.50  E-value: 5.25e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1512483039   1 YWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNP 49
Cdd:cd09820   373 YLFGPLEFSRRDLMALNIQRGRDHGLPDYNTAREAFGLPPRTTWSDINP 421
An_peroxidase pfam03098
Animal haem peroxidase;
4-53 3.48e-12

Animal haem peroxidase;


Pssm-ID: 460804 [Multi-domain]  Cd Length: 531  Bit Score: 58.34  E-value: 3.48e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1512483039   4 GPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDP 53
Cdd:pfam03098 386 PPGEFSGLDLAALNIQRGRDHGLPGYNDYREFCGLPPAKSFEDLTDVIPN 435
 
Name Accession Description Interval E-value
dual_peroxidase_like cd09820
Dual oxidase and related animal heme peroxidases; Animal heme peroxidases of the dual-oxidase ...
1-49 5.25e-21

Dual oxidase and related animal heme peroxidases; Animal heme peroxidases of the dual-oxidase like subfamily play vital roles in the innate mucosal immunity of gut epithelia. They provide reactive oxygen species which help control infection.


Pssm-ID: 188652 [Multi-domain]  Cd Length: 558  Bit Score: 83.50  E-value: 5.25e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1512483039   1 YWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNP 49
Cdd:cd09820   373 YLFGPLEFSRRDLMALNIQRGRDHGLPDYNTAREAFGLPPRTTWSDINP 421
An_peroxidase pfam03098
Animal haem peroxidase;
4-53 3.48e-12

Animal haem peroxidase;


Pssm-ID: 460804 [Multi-domain]  Cd Length: 531  Bit Score: 58.34  E-value: 3.48e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1512483039   4 GPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDP 53
Cdd:pfam03098 386 PPGEFSGLDLAALNIQRGRDHGLPGYNDYREFCGLPPAKSFEDLTDVIPN 435
peroxinectin_like_bacterial cd09822
Uncharacterized family of heme peroxidases, mostly bacterial; Animal heme peroxidases are ...
3-47 8.39e-10

Uncharacterized family of heme peroxidases, mostly bacterial; Animal heme peroxidases are diverse family of enzymes which are not restricted to animals. Members are also found in metazoans, fungi, and plants, and also in bacteria - like most members of this family of uncharacterized proteins.


Pssm-ID: 188654 [Multi-domain]  Cd Length: 420  Bit Score: 51.54  E-value: 8.39e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1512483039   3 PGPGKFsrtDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDL 47
Cdd:cd09822   281 PGAGGF---DLAALNIQRGRDHGLPSYNQLREALGLPAVTSFSDI 322
peroxinectin_like cd09823
peroxinectin_like animal heme peroxidases; Peroxinectin is an arthropod protein that plays a ...
5-53 3.91e-06

peroxinectin_like animal heme peroxidases; Peroxinectin is an arthropod protein that plays a role in invertebrate immunity mechanisms. Specifically, peroxinectins are secreted as cell-adhesive and opsonic peroxidases. The immunity mechanism appears to involve an interaction between peroxinectin and a transmembrane receptor of the integrin family. Human myeloperoxidase, which is included in this wider family, has also been reported to interact with integrins.


Pssm-ID: 188655 [Multi-domain]  Cd Length: 378  Bit Score: 41.02  E-value: 3.91e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1512483039   5 PGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDP 53
Cdd:cd09823   245 GGNPFGLDLAALNIQRGRDHGLPGYNDYREFCGLPRATTFDDLLGIMSP 293
peroxidasin_like cd09826
Animal heme peroxidase domain of peroxidasin and related proteins; Peroxidasin is a secreted ...
12-47 8.86e-05

Animal heme peroxidase domain of peroxidasin and related proteins; Peroxidasin is a secreted heme peroxidase which is involved in hydrogen peroxide metabolism and peroxidative reactions in the cardiovascular system. The domain co-occurs with extracellular matrix domains and may play a role in the formation of the extracellular matrix.


Pssm-ID: 188658  Cd Length: 440  Bit Score: 37.29  E-value: 8.86e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1512483039  12 DYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDL 47
Cdd:cd09826   290 DLAALNIQRGRDHGLPGYNDYRKFCNLSVAETFEDL 325
An_peroxidase_like cd05396
Animal heme peroxidases and related proteins; A diverse family of enzymes, which includes ...
1-53 1.84e-04

Animal heme peroxidases and related proteins; A diverse family of enzymes, which includes prostaglandin G/H synthase, thyroid peroxidase, myeloperoxidase, linoleate diol synthase, lactoperoxidase, peroxinectin, peroxidasin, and others. Despite its name, this family is not restricted to metazoans: members are found in fungi, plants, and bacteria as well.


Pssm-ID: 188647 [Multi-domain]  Cd Length: 370  Bit Score: 36.64  E-value: 1.84e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1512483039   1 YWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDP 53
Cdd:cd05396   237 FLFGPLEGVGLDLAALNIQRGRDLGLPSYNEVRRFIGLKPPTSFQDILTDPEL 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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