frizzled-related protein, partial [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| NTR_like super family | cl02512 | NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in ... |
1-66 | 1.29e-38 | ||
NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the domain plays a role in controlling axon branching in neural development, while the common function of these modules in TIMPs appears to be binding to metzincins. A subset of this family is also known as the C345C domain because it occurs as a C-terminal domain in complement C3, C4 and C5. In C5, the domain interacts with various partners during the formation of the membrane attack complex. The actual alignment was detected with superfamily member cd03581: Pssm-ID: 470599 Cd Length: 111 Bit Score: 123.35 E-value: 1.29e-38
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| Name | Accession | Description | Interval | E-value | ||
| NTR_Sfrp3_like | cd03581 | NTR domain, Secreted frizzled-related protein (Sfrp) 3-like subfamily; composed of proteins ... |
1-66 | 1.29e-38 | ||
NTR domain, Secreted frizzled-related protein (Sfrp) 3-like subfamily; composed of proteins similar to human Sfrp3 and Sfrp4. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse functions and are thought to work in Wnt signaling indirectly, as modulators or antagonists by binding Wnt ligands, and directly, via the Wnt receptor, Frizzled. They participate in regulating the patterning along the anteroposterior axis in vertebrates. Human Sfrp3 may suppress the growth and invasiveness of androgen-independent prostate cancer cells. Pssm-ID: 239636 Cd Length: 111 Bit Score: 123.35 E-value: 1.29e-38
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| NTR | pfam01759 | UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein ... |
1-66 | 5.05e-18 | ||
UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein family members, and hence the existence of the UNC-6 module, was first reported in. Subsequently, many additional members of the family were identified on the basis of sequence similarity between the C-terminal domains of netrins, complement proteins C3, C4, C5, secreted frizzled-related proteins, and type I pro-collagen C-proteinase enhancer proteins (PCOLCEs), which are homologous with the N-terminal domains of tissue inhibitors of metalloproteinases (TIMPs). The TIMPs are classified as a separate family in Pfam (pfam00965). This expanded domain family has been named as the NTR module. Pssm-ID: 396359 Cd Length: 106 Bit Score: 70.83 E-value: 5.05e-18
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| C345C | smart00643 | Netrin C-terminal Domain; |
1-60 | 3.69e-05 | ||
Netrin C-terminal Domain; Pssm-ID: 214759 Cd Length: 114 Bit Score: 38.12 E-value: 3.69e-05
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| Name | Accession | Description | Interval | E-value | ||
| NTR_Sfrp3_like | cd03581 | NTR domain, Secreted frizzled-related protein (Sfrp) 3-like subfamily; composed of proteins ... |
1-66 | 1.29e-38 | ||
NTR domain, Secreted frizzled-related protein (Sfrp) 3-like subfamily; composed of proteins similar to human Sfrp3 and Sfrp4. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse functions and are thought to work in Wnt signaling indirectly, as modulators or antagonists by binding Wnt ligands, and directly, via the Wnt receptor, Frizzled. They participate in regulating the patterning along the anteroposterior axis in vertebrates. Human Sfrp3 may suppress the growth and invasiveness of androgen-independent prostate cancer cells. Pssm-ID: 239636 Cd Length: 111 Bit Score: 123.35 E-value: 1.29e-38
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| NTR_like | cd03523 | NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in ... |
1-66 | 7.57e-21 | ||
NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the domain plays a role in controlling axon branching in neural development, while the common function of these modules in TIMPs appears to be binding to metzincins. A subset of this family is also known as the C345C domain because it occurs as a C-terminal domain in complement C3, C4 and C5. In C5, the domain interacts with various partners during the formation of the membrane attack complex. Pssm-ID: 239600 Cd Length: 105 Bit Score: 77.89 E-value: 7.57e-21
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| NTR | pfam01759 | UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein ... |
1-66 | 5.05e-18 | ||
UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein family members, and hence the existence of the UNC-6 module, was first reported in. Subsequently, many additional members of the family were identified on the basis of sequence similarity between the C-terminal domains of netrins, complement proteins C3, C4, C5, secreted frizzled-related proteins, and type I pro-collagen C-proteinase enhancer proteins (PCOLCEs), which are homologous with the N-terminal domains of tissue inhibitors of metalloproteinases (TIMPs). The TIMPs are classified as a separate family in Pfam (pfam00965). This expanded domain family has been named as the NTR module. Pssm-ID: 396359 Cd Length: 106 Bit Score: 70.83 E-value: 5.05e-18
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| NTR_netrin-4_like | cd03578 | NTR domain, Netrin-4-like subfamily; composed of the C-terminal NTR domains of netrin-4 (beta ... |
1-63 | 1.06e-06 | ||
NTR domain, Netrin-4-like subfamily; composed of the C-terminal NTR domains of netrin-4 (beta netrin) and similar proteins. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration during neural development. Netrin-4 is a basement membrane component that is important in neural, kidney and vascular development. It may also be involved in regulating the outgrowth and shape of epithelial cells during lung branching morphogenesis. Pssm-ID: 239633 Cd Length: 111 Bit Score: 42.16 E-value: 1.06e-06
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| C345C | smart00643 | Netrin C-terminal Domain; |
1-60 | 3.69e-05 | ||
Netrin C-terminal Domain; Pssm-ID: 214759 Cd Length: 114 Bit Score: 38.12 E-value: 3.69e-05
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