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Conserved domains on  [gi|1417949077|gb|AWY56414|]
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GNAT family N-acetyltransferase [Burkholderia gladioli pv. gladioli]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10456837)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  15581578|10940244|9175471|27367672|26818562
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 73-163 6.12e-15

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


:

Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 67.54  E-value: 6.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417949077  73 QRASSDQSTTFLLYTEGHPAGMIGAYLDNTPERRAFVSELWVAHAVRHLRGGVLLVNTARDWLAGQGATEIYAWIAEQNR 152
Cdd:pfam00583  26 DWDEDASEGFFVAEEDGELVGFASLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNL 105

                          90
                  ....*....|.
gi 1417949077 153 NAIRFYEHMGF 163
Cdd:pfam00583 106 AAIALYEKLGF 116
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 73-163 6.12e-15

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 67.54  E-value: 6.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417949077  73 QRASSDQSTTFLLYTEGHPAGMIGAYLDNTPERRAFVSELWVAHAVRHLRGGVLLVNTARDWLAGQGATEIYAWIAEQNR 152
Cdd:pfam00583  26 DWDEDASEGFFVAEEDGELVGFASLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNL 105

                          90
                  ....*....|.
gi 1417949077 153 NAIRFYEHMGF 163
Cdd:pfam00583 106 AAIALYEKLGF 116
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 93-169 4.16e-10

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 54.28  E-value: 4.16e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1417949077  93 GMIGAYLdNTPERRAFVSELWVAHAVRHlRG-GVLLVNTARDWLAGQGATEIYAWIAEQNRNAIRFYEHMGFTNLGEH 169
Cdd:COG0456     1 GFALLGL-VDGGDEAEIEDLAVDPEYRG-RGiGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGER 76
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 83-146 5.37e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.57  E-value: 5.37e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1417949077  83 FLLYTEGHPAGMIGAYLDNTPERRAFVSELWVAHAVRHLRGGVLLVNTARDWLAGQGATEIYAW 146
Cdd:cd04301     2 LVAEDDGEIVGFASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 73-163 6.12e-15

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 67.54  E-value: 6.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417949077  73 QRASSDQSTTFLLYTEGHPAGMIGAYLDNTPERRAFVSELWVAHAVRHLRGGVLLVNTARDWLAGQGATEIYAWIAEQNR 152
Cdd:pfam00583  26 DWDEDASEGFFVAEEDGELVGFASLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNL 105

                          90
                  ....*....|.
gi 1417949077 153 NAIRFYEHMGF 163
Cdd:pfam00583 106 AAIALYEKLGF 116
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 93-169 4.16e-10

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 54.28  E-value: 4.16e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1417949077  93 GMIGAYLdNTPERRAFVSELWVAHAVRHlRG-GVLLVNTARDWLAGQGATEIYAWIAEQNRNAIRFYEHMGFTNLGEH 169
Cdd:COG0456     1 GFALLGL-VDGGDEAEIEDLAVDPEYRG-RGiGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGER 76
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 73-168 4.67e-10

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 55.06  E-value: 4.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417949077  73 QRASSDQSTTFLL-YTEGHPAGMIGayLDNTPERRAFVSELWVAHAVRHLRGGVLLVNTARDWLAGQGATEIYAWIAEQN 151
Cdd:COG0454    26 AMEGSLAGAEFIAvDDKGEPIGFAG--LRRLDDKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGN 103

                          90
                  ....*....|....*..
gi 1417949077 152 RNAIRFYEHMGFTNLGE 168
Cdd:COG0454   104 PAAIRFYERLGFKEIER 120
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
88-186 2.21e-09

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 53.85  E-value: 2.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417949077  88 EGHPAGMIGAYLDNTPERRAFVSE--LWVAHAVRHlRG-GVLLVNTARDWLAGQGATEIYAWIAEQNRNAIRFYEHMGFT 164
Cdd:COG1247    60 DGEVVGFASLGPFRPRPAYRGTAEesIYVDPDARG-RGiGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFE 138

                          90       100
                  ....*....|....*....|..
gi 1417949077 165 NLGEHAPIARVPGAMKSLFVWR 186
Cdd:COG1247   139 EVGTLPEVGFKFGRWLDLVLMQ 160
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 83-186 1.39e-06

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 45.75  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417949077  83 FLLYTEGHPAGMIGayLDNTPERRAFVSELWVAHAVRHLRGGVLLVNTARDWLAGQGATEIYAWIaeqNRNAIRFYEHMG 162
Cdd:COG1246    31 WVAEEDGEIVGCAA--LHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLT---TSAAIHFYEKLG 105

                          90       100
                  ....*....|....*....|....
gi 1417949077 163 FTNLGEHAPIARVPGAMKSLFVWR 186
Cdd:COG1246   106 FEEIDKEDLPYAKVWQRDSVVMEK 129
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 78-164 2.41e-06

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 43.98  E-value: 2.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417949077  78 DQSTTFLLYTEGHPAGMIGAYLDNTPERRAFVSeLWVAHAVRHlRG-GVLLVNTARDWLAGQGATEIYAwiaEQNRNAIR 156
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDDEGALAELR-LAVHPEYRG-QGiGRALLEAAEAAAKEGGIKLLEL---ETTNRAAA 75


                  ....*...
gi 1417949077 157 FYEHMGFT 164
Cdd:pfam13508  76 FYEKLGFE 83
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
74-169 1.71e-05

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 42.77  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417949077  74 RASSDQSTTFLLYTEGHPAGMIGAYL--DNTPERRAFVSELWVAHAVRHlRG-GVLLVNTARDWLAGQGATEIYAWiaeQ 150
Cdd:COG3153    33 REDPAAGLSLVAEDDGEIVGHVALSPvdIDGEGPALLLGPLAVDPEYRG-QGiGRALMRAALEAARERGARAVVLL---G 108

                          90
                  ....*....|....*....
gi 1417949077 151 NRNAIRFYEHMGFTNLGEH 169
Cdd:COG3153   109 DPSLLPFYERFGFRPAGEL 127
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 83-146 5.37e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.57  E-value: 5.37e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1417949077  83 FLLYTEGHPAGMIGAYLDNTPERRAFVSELWVAHAVRHLRGGVLLVNTARDWLAGQGATEIYAW 146
Cdd:cd04301     2 LVAEDDGEIVGFASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 88-186 3.28e-04

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 39.60  E-value: 3.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417949077  88 EGHPAGMIGAYLDNTPERRAFVSeLWVAHAVRHlRG-GVLLVNTARDWLAGQ-GATEIYAWIAEQNRNAIRFYEHMGFTN 165
Cdd:COG1670    70 DGELIGVVGLYDIDRANRSAEIG-YWLAPAYWG-KGyATEALRALLDYAFEElGLHRVEAEVDPDNTASIRVLEKLGFRL 147

                          90       100
                  ....*....|....*....|.
gi 1417949077 166 LGEHAPIARVPGAMKSLFVWR 186
Cdd:COG1670   148 EGTLRDALVIDGRYRDHVLYS 168
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 73-168 1.49e-03

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 37.25  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417949077  73 QRASSDQSTTFLLYTEGHPAGMIGAYldntpeRRAFVSELWVAHAVRHlRG-GVLLVNTARDWLAGQGAtEIYAWIAEQN 151
Cdd:pfam13673  24 ERIDQGEYFFFVAFEGGQIVGVIALR------DRGHISLLFVDPDYQG-QGiGKALLEAVEDYAEKDGI-KLSELTVNAS 95

                          90
                  ....*....|....*..
gi 1417949077 152 RNAIRFYEHMGFTNLGE 168
Cdd:pfam13673  96 PYAVPFYEKLGFRATGP 112
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
90-168 2.69e-03

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 35.65  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417949077  90 HPAGMIGAYLDNtpERRAFVSELWVAHAVRHlRG-GVLLVNTARDWLAGQGATEIYAWIAEQNRNAIRFYEHMGFTNLGE 168
Cdd:COG3393     1 ELVAMAGVRAES--PGVAEISGVYTHPEYRG-RGlASALVAALAREALARGARTPFLYVDADNPAARRLYERLGFRPVGE 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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