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Conserved domains on  [gi|1368342677|gb|AVP48984|]
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ROK family protein [Williamsoniiplasma luminosum]

Protein Classification

ROK family protein( domain architecture ID 19235420)

ROK (Repressor, ORF, Kinase) family protein functions as a sugar kinase and/or a transcriptional regulator involved in carbohydrate-dependent transcriptional control

CATH:  3.30.420.40
PubMed:  20512568
SCOP:  4000330

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 1-287 5.57e-86

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


:

Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 259.04  E-value: 5.57e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   1 MNLVLDIGGMSTKIAICDNNNKFIYRHNFSYPNLisidvLVRELEQRIFDIILT--NKIDNICISSPGNVNPVSGEIKGL 78
Cdd:cd24152     1 KYLVFDIGGTFIKYALVDENGNIIKKGKIPTPKD-----SLEEFLDYIKKIIKRydEEIDGIAISAPGVIDPETGIIYGG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  79 SAIQGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGEYGY 158
Cdd:cd24152    76 GALPYLKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIGGAIIIDGKLYRGSHFFAGEFSY 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 159 LLNTKYGNDrYLNVSQSIGIANLIQSFKKRTNKE-VNGEQIYDLYNT-DNDAKTVVEEMIHNTSKLIYNLSFIIDPDLIL 236
Cdd:cd24152   156 LLTDDDDKD-LLFFSGLASMFGLVKRYNKAKGLEpLDGEEIFEKYAKgDEAAKKILDEYIRNLAKLIYNIQYILDPEVIV 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1368342677 237 IGGAISKNILFINLVNKELKTLYKKI-GLEPQFLIKSCKYYNDSNLIGANML 287
Cdd:cd24152   235 IGGGISEQPLFIEDLKKEVNEILANRpGSIPKPEIKACKFGNDANLLGALYN 286
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 1-287 5.57e-86

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 259.04  E-value: 5.57e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   1 MNLVLDIGGMSTKIAICDNNNKFIYRHNFSYPNLisidvLVRELEQRIFDIILT--NKIDNICISSPGNVNPVSGEIKGL 78
Cdd:cd24152     1 KYLVFDIGGTFIKYALVDENGNIIKKGKIPTPKD-----SLEEFLDYIKKIIKRydEEIDGIAISAPGVIDPETGIIYGG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  79 SAIQGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGEYGY 158
Cdd:cd24152    76 GALPYLKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIGGAIIIDGKLYRGSHFFAGEFSY 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 159 LLNTKYGNDrYLNVSQSIGIANLIQSFKKRTNKE-VNGEQIYDLYNT-DNDAKTVVEEMIHNTSKLIYNLSFIIDPDLIL 236
Cdd:cd24152   156 LLTDDDDKD-LLFFSGLASMFGLVKRYNKAKGLEpLDGEEIFEKYAKgDEAAKKILDEYIRNLAKLIYNIQYILDPEVIV 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1368342677 237 IGGAISKNILFINLVNKELKTLYKKI-GLEPQFLIKSCKYYNDSNLIGANML 287
Cdd:cd24152   235 IGGGISEQPLFIEDLKKEVNEILANRpGSIPKPEIKACKFGNDANLLGALYN 286
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 3-287 1.06e-47

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 161.60  E-value: 1.06e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   3 LVLDIGGMSTKIAICDNNNKFIYRHNFSYPNLISIDVLVRELEQRIFDIILTNKIDN-----ICISSPGNVNPVSGEIKG 77
Cdd:COG1940     8 IGIDIGGTKIKAALVDLDGEVLARERIPTPAGAGPEAVLEAIAELIEELLAEAGISRgrilgIGIGVPGPVDPETGVVLN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  78 LSAIQGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNvvvivigtgvggS------------LIIDGKI 145
Cdd:COG1940    88 APNLPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADN------------VvyltlgtgigggIVINGKL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 146 HRGNHFFAGEYGYLL----NTKYGNDRYLNVSQSIGIANLIQSFKKRTNKE-VNGEQIYDLYNT-DNDAKTVVEEMIHNT 219
Cdd:COG1940   156 LRGANGNAGEIGHMPvdpdGPLCGCGNRGCLETYASGPALLRRARELGGAEkLTAEELFAAARAgDPLALEVLDEAARYL 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 220 SKLIYNLSFIIDPDLILIGGAISKNI-LFINLVNKELKT-LYKKIGLEPQflIKSCKYYNDSNLIGANML 287
Cdd:COG1940   236 GIGLANLINLLDPEVIVLGGGVSAAGdLLLEPIREALAKyALPPAREDPR--IVPASLGDDAGLLGAAAL 303
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 5-284 1.01e-21

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 92.40  E-value: 1.01e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   5 LDIGGmsTKIAIC--DNNNKFIYRHNFSYPNLI-------SIDVLVRELEQRifdiilTNKIDNICISSPGNVNPVSGEI 75
Cdd:pfam00480   3 IDIGG--TKIAAAlfDEEGEILARERVPTPTTTteetlvdAIAFFVDSAQRK------FGELIAVGIGSPGLISPKYGYI 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  76 KGLSAIQGLEtFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGE 155
Cdd:pfam00480  75 TNTPNIGWDN-FDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 156 YGYLL---NTKYGNDRYLNVSQSIgIANliQSFKKRTNKEVNG----EQIYDLYNTDNDAKTVVEEMIHNTSKLIYNLSF 228
Cdd:pfam00480 154 IGHIQldpNGPKCGCGNHGCLETI-ASG--RALEKRYQQKGEDlegkDIIVLAEQGDEVAEEAVERLARYLAKAIANLIN 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1368342677 229 IIDPDLILIGGAISKNILFINLVNKELKT-LYKKIGLEPQFLIKScKYYNDSNLIGA 284
Cdd:pfam00480 231 LFDPQAIVLGGGVSNADGLLEAIRSLVKKyLNGYLPVPPVIIVAA-SLGDNAGALGA 286
ROK_glcA_fam TIGR00744
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ...
 3-296 7.71e-13

ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]


Pssm-ID: 273246 [Multi-domain]  Cd Length: 318  Bit Score: 67.62  E-value: 7.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   3 LVLDIGGMSTKIAICDNNNKFIYRHNFSYPNL--ISIDVLVRELEQRIFDII-LTNKIDNICISSPGNVNPVSGEIKGLS 79
Cdd:TIGR00744   1 IGVDIGGTTIKLGVVDEEGNILSKWKVPTDTTpeTIVDAIASAVDSFIQHIAkVGHEIVAIGIGAPGPVNRQRGTVYFAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  80 AIqGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGEYGYL 159
Cdd:TIGR00744  81 NL-DWKQEPLKEKVEARVGLPVVVENDANAAALGEYKKGAGKGARDVICITLGTGLGGGIIINGEIRHGHNGVGAEIGHI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 160 LNTKYGNDR--------YLNVSQSIGIANLIQ------SFKKRTNKEVNGEQI--YDLYNT----DNDAKTVVEEMIHNT 219
Cdd:TIGR00744 160 RMVPDGRLLcncgkqgcIETYASATGLVRYAKranakpERAEVLLALGDGDGIsaKHVFVAarqgDPVAVDSYREVARWA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 220 SKLIYNLSFIIDPDLILIGGAISKNILfinLVNKELKTLYKKI---GLEPQFLIKSCKYYNDSNLIGANMLSSLFGVKVD 296
Cdd:TIGR00744 240 GAGLADLASLFNPSAIVLGGGLSDAGD---LLLDPIRKSYKRWlfgGARQVADIIAAQLGNDAGLVGAADLARTYIIEPD 316
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 1-284 1.76e-09

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 57.62  E-value: 1.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   1 MN-LVLDIGGmsTKI--AICDNNNKFIYRHNFSYPNLISIDVLVRELEQRIFDiiLTNKIDNICISSPGNVNPvsgeiKG 77
Cdd:PRK05082    1 MTtLAIDIGG--TKIaaALVGEDGQIRQRRQIPTPASQTPEALRQALSALVSP--LQAQADRVAVASTGIIND-----GI 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  78 LSAIQ-----GLETFNFKLTWEPKFKLPVFIDNDANCAAIAEleYGNAKNE-KNVVVIVIGTGVGGSLIIDGKIHRGNHF 151
Cdd:PRK05082   72 LTALNphnlgGLLHFPLVQTLEQLTDLPTIALNDAQAAAWAE--YQALPDDiRNMVFITVSTGVGGGIVLNGKLLTGPGG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 152 FAGEYGYLL----NTKYGNDRYLNVsQSIGIANLIQSFKKRTNKEVNGEQIYDLYNTDN-DAKTVVEEMIHNTSKLIYNL 226
Cdd:PRK05082  150 LAGHIGHTLadphGPVCGCGRRGCV-EAIASGRAIAAAAQGWLAGCDAKTIFERAGQGDeQAQALINRSAQAIARLIADL 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1368342677 227 SFIIDPDLILIGGAISKNILFINLVNKELKTlykkiglEPQFL---IKSCKYYNDSNLIGA 284
Cdd:PRK05082  229 KATLDCQCVVLGGSVGLAEGYLELVQAYLAQ-------EPAIYhvpLLAAHYRHDAGLLGA 282
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 1-287 5.57e-86

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 259.04  E-value: 5.57e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   1 MNLVLDIGGMSTKIAICDNNNKFIYRHNFSYPNLisidvLVRELEQRIFDIILT--NKIDNICISSPGNVNPVSGEIKGL 78
Cdd:cd24152     1 KYLVFDIGGTFIKYALVDENGNIIKKGKIPTPKD-----SLEEFLDYIKKIIKRydEEIDGIAISAPGVIDPETGIIYGG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  79 SAIQGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGEYGY 158
Cdd:cd24152    76 GALPYLKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIGGAIIIDGKLYRGSHFFAGEFSY 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 159 LLNTKYGNDrYLNVSQSIGIANLIQSFKKRTNKE-VNGEQIYDLYNT-DNDAKTVVEEMIHNTSKLIYNLSFIIDPDLIL 236
Cdd:cd24152   156 LLTDDDDKD-LLFFSGLASMFGLVKRYNKAKGLEpLDGEEIFEKYAKgDEAAKKILDEYIRNLAKLIYNIQYILDPEVIV 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1368342677 237 IGGAISKNILFINLVNKELKTLYKKI-GLEPQFLIKSCKYYNDSNLIGANML 287
Cdd:cd24152   235 IGGGISEQPLFIEDLKKEVNEILANRpGSIPKPEIKACKFGNDANLLGALYN 286
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 3-287 1.06e-47

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 161.60  E-value: 1.06e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   3 LVLDIGGMSTKIAICDNNNKFIYRHNFSYPNLISIDVLVRELEQRIFDIILTNKIDN-----ICISSPGNVNPVSGEIKG 77
Cdd:COG1940     8 IGIDIGGTKIKAALVDLDGEVLARERIPTPAGAGPEAVLEAIAELIEELLAEAGISRgrilgIGIGVPGPVDPETGVVLN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  78 LSAIQGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNvvvivigtgvggS------------LIIDGKI 145
Cdd:COG1940    88 APNLPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADN------------VvyltlgtgigggIVINGKL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 146 HRGNHFFAGEYGYLL----NTKYGNDRYLNVSQSIGIANLIQSFKKRTNKE-VNGEQIYDLYNT-DNDAKTVVEEMIHNT 219
Cdd:COG1940   156 LRGANGNAGEIGHMPvdpdGPLCGCGNRGCLETYASGPALLRRARELGGAEkLTAEELFAAARAgDPLALEVLDEAARYL 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 220 SKLIYNLSFIIDPDLILIGGAISKNI-LFINLVNKELKT-LYKKIGLEPQflIKSCKYYNDSNLIGANML 287
Cdd:COG1940   236 GIGLANLINLLDPEVIVLGGGVSAAGdLLLEPIREALAKyALPPAREDPR--IVPASLGDDAGLLGAAAL 303
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 3-284 2.13e-47

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 160.42  E-value: 2.13e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   3 LVLDIGGMSTKIAICDNNNKFIYRHNFSypnlISIDVLVRELEQRIFDIILTNK----IDNICISSPGNVNPVSGEIKGL 78
Cdd:cd24068     3 LGIDIGGTKIKYGLVDADGEILEKDSVP----TPASKGGDAILERLLEIIAELKekydIEGIGISSAGQVDPKTGEVIYA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  79 SA-IQGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGEYG 157
Cdd:cd24068    79 TDnLPGWTGTNLKEELEERFGLPVAVENDVNCAALAEKWLGAAKGLDDFLCLTLGTGIGGAIILDGRLYRGANGSAGELG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 158 YLL------NTKYGNDRYLNVSQSiGIAnLIQSFKKRTNKE-VNGEQIYDLYNT-DNDAKTVVEEMIHNTSKLIYNLSFI 229
Cdd:cd24068   159 HMVvdpggrPCCCGGKGCLEQYAS-GTA-LVRRVAEALGEPgIDGREIFDLADAgDPLAKEVVEEFAEDLATGLANLVHI 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1368342677 230 IDPDLILIGGAISK-NILFINLVNKELKTLYKKIGLEPqFLIKSCKYYNDSNLIGA 284
Cdd:cd24068   237 FDPEVIVIGGGISAqGELFLEELREELRKLLMPPLLDA-TKIEPAKLGNDAGLLGA 291
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 5-287 2.37e-31

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 116.79  E-value: 2.37e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   5 LDIGGMSTKIAICDNNNKFIYRHNFSYPNLISIDVLVRELEQRIFDII----LTNKIDNICISSPGNVNPVSGEIKGLSA 80
Cdd:cd23763     3 IDIGGTKIRAALVDLDGEILARERVPTPAEEGPEAVLDRIAELIEELLaeagVRERILGIGIGVPGPVDPETGIVLFAPN 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  81 IQGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNvvvivigtgvggSLIIDGKIHRGNHFFAGEYGYLl 160
Cdd:cd23763    83 LPWWKNVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRGVRNfvyitlgtgiggGIIIDGKLYRGANGAAGEIGHI- 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 161 ntkygndrylnvsqsigianliqsfkkrtnkevngeqiydlyntdndakTVVEEMIHNTSKLIYNLSFIIDPDLILIGGA 240
Cdd:cd23763   162 -------------------------------------------------TVLEEAARYLGIGLANLINLLNPELIVLGGG 192

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1368342677 241 ISKNI-LFINLVNKELKTLYKKIGLEPqFLIKSCKYYNDSNLIGANML 287
Cdd:cd23763   193 VAEAGdLLLEPIREAVRRRALPPLRRR-VRIVPSELGDDAGLLGAAAL 239
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 5-239 1.29e-24

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 100.35  E-value: 1.29e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   5 LDIGGMSTKIAICDNNNKFIYRHNFSYPNLISIDVLVRELEQRIFDII----LTNKIDNICISSPGNVNPVSGEIKGLSA 80
Cdd:cd24059     6 VEIGRDLLSAVLCDLSGNILAREKYPLDEKENPEEVLEKLYELIDRLLekenIKSKILGIGIGAPGPLDVEKGIILNPPN 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  81 IQGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGEYGYLL 160
Cdd:cd24059    86 FPGWENIPLVELLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGVDGYAGEIGHTS 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 161 ---NTKY---GNDRYLNVsqSIGIANLIQSFKKRTNKEV-NGEQIYDLYNTDN-DAKTVVEEMIHNTSKLIYNLSFIIDP 232
Cdd:cd24059   166 idiNGPRcscGNRGCLEL--YASIPAIEKKARSALGSGRsFQLDIVEALQKGDpIADEVIEEAAKYLGIGLVNLINLLNP 243


                  ....*..
gi 1368342677 233 DLILIGG 239
Cdd:cd24059   244 EAIIIGG 250
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 5-284 1.01e-21

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 92.40  E-value: 1.01e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   5 LDIGGmsTKIAIC--DNNNKFIYRHNFSYPNLI-------SIDVLVRELEQRifdiilTNKIDNICISSPGNVNPVSGEI 75
Cdd:pfam00480   3 IDIGG--TKIAAAlfDEEGEILARERVPTPTTTteetlvdAIAFFVDSAQRK------FGELIAVGIGSPGLISPKYGYI 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  76 KGLSAIQGLEtFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGE 155
Cdd:pfam00480  75 TNTPNIGWDN-FDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 156 YGYLL---NTKYGNDRYLNVSQSIgIANliQSFKKRTNKEVNG----EQIYDLYNTDNDAKTVVEEMIHNTSKLIYNLSF 228
Cdd:pfam00480 154 IGHIQldpNGPKCGCGNHGCLETI-ASG--RALEKRYQQKGEDlegkDIIVLAEQGDEVAEEAVERLARYLAKAIANLIN 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1368342677 229 IIDPDLILIGGAISKNILFINLVNKELKT-LYKKIGLEPQFLIKScKYYNDSNLIGA 284
Cdd:pfam00480 231 LFDPQAIVLGGGVSNADGLLEAIRSLVKKyLNGYLPVPPVIIVAA-SLGDNAGALGA 286
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 13-287 3.44e-18

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 82.72  E-value: 3.44e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  13 KIAICDNNNKFIYRHNFSY-----PNLIsIDVLVRELEQRIFDIILTNKIDNICISSPGNVNPVSGEIKGlSAIQGLETF 87
Cdd:cd24071    14 VLALTDLKGKILEKTRIPFdhetdPEKV-IELIAENIKKLIKNKHVEKKLLGIGIAVSGLVDSKKGIVIR-STILGWENV 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  88 NFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGEYGYLLNTK---- 163
Cdd:cd24071    92 ELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICVTVGAGIGSSLVIDGKLYTGNFGGAGEIGHMTIQPdgrk 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 164 -----------YGNDRYL-NVSQSIGIANLIQSFKKRTNKEVngEQIYD-LYNTDNDAKTVVEEMIHNTSKLIYNLSFII 230
Cdd:cd24071   172 cycgqkgcleaYASFEALvNEIKELTESYPLSLLKELEDFEI--EKVREaAEEGDSVATELFKKAGEYLGIGIKNLINIF 249

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1368342677 231 DPDLILIGGA--ISKNILFINLVNKELKTLYKKIGLEPQFLIKSCKyyNDSNLIGANML 287
Cdd:cd24071   250 NPEAIIIGGEglEFKDYFLPKIIEIAKENFFGKAGRNVIILVDSLG--EDAWVLGAALL 306
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 5-244 1.48e-16

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 78.14  E-value: 1.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   5 LDIGGmsTKIAI-CDNNNKFIYRHNFSYPN------LISIDVLVRELEQRifdiilTNKIDNICISSPGNVNPVSGEIKG 77
Cdd:cd24065     5 LDLGG--TKIAAgVVDGGRILSRLVVPTPReggeavLDALARAVEALQAE------APGVEAVGLGVPGPLDFRRGRVRF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  78 LSAIQGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGEYG 157
Cdd:cd24065    77 APNIPGLTDFPIRRGLAERLGLPVVLENDANAAALAEHHYGAARGTESSVYVTISTGIGGGLVLGGRVLRGRHGQAGEIG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 158 YLLNTKY------GNDRYLNvSQSIGIAnLIQSFKKRTNKEVNGEQIYDLYNT-DNDAKTVVEEMIHNTSKLIYNLSFII 230
Cdd:cd24065   157 HTTVLPGgpmcgcGLVGCLE-ALASGRA-LARDASFAYGRPMSTAELFELAQQgEPKALRIVEQAAAHLGIGLANLQKAL 234

                         250
                  ....*....|....
gi 1368342677 231 DPDLILIGGAISKN 244
Cdd:cd24065   235 DPEVFVLGGGVAQV 248
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 6-284 5.80e-15

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 73.86  E-value: 5.80e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   6 DIGGMSTKIAICDNNNKFIYRH------NFSYPNLI-----SIDVLVRELEQRIFDIIltnkidNICISSPGNVNPVSGE 74
Cdd:cd24062     6 DVGGTTIKMAFLTQEGEIVQKWeiptnkLEGGENIItdiaeSIQQLLEELGYSKEDLI------GIGVGVPGPVDVETGT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  75 IKGLSAIqGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAG 154
Cdd:cd24062    80 VEVAVNL-GWKNFPLKDKLEALTGIPVVIDNDANAAALGEMWKGAGQGAKDLVFITLGTGVGGGVIANGKIVHGANGAAG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 155 EYGYL-LNTKYGndRYLN---------VSQSIGIANL----IQSFKKRT-------NKEVNGEQIYDLYNTDND-AKTVV 212
Cdd:cd24062   159 EIGHItVNPEGG--APCNcgktgcletVASATGIVRIareeLEEGKGSSalrilalGGELTAKDVFEAAKAGDElALAVV 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1368342677 213 EEMIHNTSKLIYNLSFIIDPDLILIGGAISK--NILFinlvnKELKTLYKKIGLePQFL----IKSCKYYNDSNLIGA 284
Cdd:cd24062   237 DTVARYLGLALANLANTLNPEKIVIGGGVSAagEFLL-----SPVKEYFDRFTF-PRVRqdteIVLATLGNDAGVIGA 308
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 60-242 6.91e-14

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 70.67  E-value: 6.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  60 ICISSPGNVNPVSGEIkGLSAIQGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSL 139
Cdd:cd24076    66 IGVGVPGLVDSEDGVV-LLAPNLGWRDVPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGI 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 140 IIDGKIHRGNHFFAGEYGYllNTKYGNDRYLN------VSQSIGIANLIQSFKKRTNKEVNG--EQIYDLYNT-DNDAKT 210
Cdd:cd24076   145 ILDGELYRGASGFAGEIGH--MTVDPDGPPCScgnrgcWETYASERALLRAAGRLGAGGEPLslAELVEAARAgDPAALA 222

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1368342677 211 VVEEMIHNTSKLIYNLSFIIDPDLILIGGAIS 242
Cdd:cd24076   223 ALEEVGEYLGIGLANLVNTFNPELVVLGGALA 254
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 6-243 2.16e-13

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 69.16  E-value: 2.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   6 DIGGMSTKIAICDNNNKFIYRHNFSYPN------LISIDVLVRELEQRIfdiiltNKIDNICISSPGNVNPVSGEIKGlS 79
Cdd:cd24066     5 DLGGTKIEGIALDRAGRELLRRRVPTPRgdyeatLDAIADLVEEAEEEL------GAPATVGIGTPGSISPRTGLVKN-A 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  80 AIQGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGEYGYl 159
Cdd:cd24066    78 NSTWLNGKPLKADLEARLGRPVRIENDANCFALSEATDGAGAGAGVVFGVILGTGVGGGIVVNGRVLTGANGIAGEWGH- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 160 lNT-KYGNDRYLN-----------VSQSIGIANLIQSFKKRTNKEVNGEQIYDLYNT-DNDAKTVVEEMIHNTSKLIYNL 226
Cdd:cd24066   157 -NPlPWPDEDELPgppcycgkrgcVETFLSGPALERDYARLTGKTLSAEEIVALARAgDAAAVATLDRFLDRLGRALANV 235

                         250
                  ....*....|....*..
gi 1368342677 227 SFIIDPDLILIGGAISK 243
Cdd:cd24066   236 INILDPDVIVLGGGLSN 252
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 6-284 4.81e-13

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 68.15  E-value: 4.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   6 DIGGMSTKIAICDNNNKFIYRHNFSYPNLIS--IDV---LVRELEQRiFDIIltnkidNICISSPGNVNPVSGEIKGLSA 80
Cdd:cd24061     5 DIGGTKIAAGVVDEEGEILATERVPTPPTADgiVDAiveAVEELREG-HDVS------AVGVAAAGFVDADRATVLFAPN 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  81 IqGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGEYGYLL 160
Cdd:cd24061    78 I-AWRNEPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDMVMITVGTGLGGGIVIGGKLLRGAFGIAGEFGHIR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 161 NT---------------KYGNDRYL-NVSQSIGIANLIQSFKKRTNKEVN---GEQIYDLYNT-DNDAKTVVEEMIHNTS 220
Cdd:cd24061   157 VVpdgllcgcgsrgcweQYASGRALvRYAKEAANATPEGAAVLLADGSVDgitGKHISEAARAgDPVALDALRELARWLG 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1368342677 221 KLIYNLSFIIDPDLILIGGAISKN-ILFINLVNKELKTLYKKIGL--EPQFLIKSCkyYNDSNLIGA 284
Cdd:cd24061   237 AGLASLAALLDPELFVIGGGVSDAgDLLLDPIREAFERWLPGRGWrpIPRLRTAQL--GNDAGLIGA 301
ROK_glcA_fam TIGR00744
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ...
 3-296 7.71e-13

ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]


Pssm-ID: 273246 [Multi-domain]  Cd Length: 318  Bit Score: 67.62  E-value: 7.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   3 LVLDIGGMSTKIAICDNNNKFIYRHNFSYPNL--ISIDVLVRELEQRIFDII-LTNKIDNICISSPGNVNPVSGEIKGLS 79
Cdd:TIGR00744   1 IGVDIGGTTIKLGVVDEEGNILSKWKVPTDTTpeTIVDAIASAVDSFIQHIAkVGHEIVAIGIGAPGPVNRQRGTVYFAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  80 AIqGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGEYGYL 159
Cdd:TIGR00744  81 NL-DWKQEPLKEKVEARVGLPVVVENDANAAALGEYKKGAGKGARDVICITLGTGLGGGIIINGEIRHGHNGVGAEIGHI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 160 LNTKYGNDR--------YLNVSQSIGIANLIQ------SFKKRTNKEVNGEQI--YDLYNT----DNDAKTVVEEMIHNT 219
Cdd:TIGR00744 160 RMVPDGRLLcncgkqgcIETYASATGLVRYAKranakpERAEVLLALGDGDGIsaKHVFVAarqgDPVAVDSYREVARWA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 220 SKLIYNLSFIIDPDLILIGGAISKNILfinLVNKELKTLYKKI---GLEPQFLIKSCKYYNDSNLIGANMLSSLFGVKVD 296
Cdd:TIGR00744 240 GAGLADLASLFNPSAIVLGGGLSDAGD---LLLDPIRKSYKRWlfgGARQVADIIAAQLGNDAGLVGAADLARTYIIEPD 316
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 3-241 7.95e-13

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 67.19  E-value: 7.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   3 LVLDIGGMSTKIAICDNNNK--FIYRHN----FSYPNLISidVLVRELEQRIFDiiLTNKIDNICISSPGNVNPVSGEIk 76
Cdd:cd24070     4 LGIDIGGTNIRIGLVDEDGKllDFEKVPskdlLRAGDPVE--VLADLIREYIEE--AGLKPAAIVIGVPGTVDKDRRTV- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  77 gLSA--IQGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAG 154
Cdd:cd24070    79 -ISTpnIPGLDGVNLADILENKLGIPVILERDVNLLLLYDMRAGNLDDEGVVLGFYIGTGIGNAILINGKPLRGKNGVAG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 155 EYG---YLLNTK------------YGNDRYLnvsqsigianliQSFKKRTNKEVNGEQIYdlynTDNDAKTVVEEMIHNT 219
Cdd:cd24070   158 ELGhipVYGNGKpcgcgntgcletYASGRAL------------EEIAEEHYPDTPILDIF----VDHGDEPELDEFVEDL 221

                         250       260
                  ....*....|....*....|..
gi 1368342677 220 SKLIYNLSFIIDPDLILIGGAI 241
Cdd:cd24070   222 ALAIATEINILDPDAVILGGGV 243
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 1-287 6.09e-12

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 64.95  E-value: 6.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   1 MNLVLDIGGmsTKIAIC--DNNNKFIYRHNF-----SYPNLIS-IDVLVRELEQRiFDIILTnkidnICISSPGNVNPVS 72
Cdd:cd24057     1 MYYGFDIGG--TKIEFAvfDEALQLVWTKRVptptdDYAAFLAaIAELVAEADAR-FGVKGP-----VGIGIPGVIDPED 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  73 GEIK--GLSAIQGLetfNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNH 150
Cdd:cd24057    73 GTLItaNIPAAKGR---PLRADLSARLGRPVRIDNDANCFALSEAWDGAGRGYPSVFGLILGTGVGGGLVVNGRLVGGRS 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 151 FFAGEYG------YLLNTKY-------GNDRYLNVSQSI---GIANLIQSFkkrTNKEVNGEQIYDLY-NTDNDAKTVVE 213
Cdd:cd24057   150 GIAGEWGhgplpaDALLLGYdlpvlrcGCGQTGCLETYLsgrGLERLYAHL---YGEELDAPEIIAAWaAGDPQAVAHVD 226

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1368342677 214 EMIHNTSKLIYNLSFIIDPDLILIGGAISKNILFINLVNKELKT-LYKKIGLePQflIKSCKYYNDSNLIGANML 287
Cdd:cd24057   227 RWLDLLAGCLANILTALDPDVVVLGGGLSNFPALIAELPAALPAhLLSGART-PR--IVPARHGDAGGVRGAAFL 298
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 3-159 8.96e-12

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 64.36  E-value: 8.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   3 LVLDIGGMSTKIAICDNNNKFIYRHNFSYP--NLISIDVLVREL-EQRIFDIILTNKIDNICISSPGNVNPVSGEI-KGL 78
Cdd:cd24060     3 LAVDLGGTNLRVAIVSMKGEIVKKYTQPNPktYEERIDLILQMCvEAASEAVKLNCRILGVGISTGGRVNPREGIVlHST 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  79 SAIQGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGEYGY 158
Cdd:cd24060    83 KLIQEWSSVDLRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITGTGIGGGIILNHELIHGSSFCAAELGH 162


                  .
gi 1368342677 159 L 159
Cdd:cd24060   163 I 163
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 3-287 1.69e-11

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 63.46  E-value: 1.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   3 LVLDIGGmsTKIAICD-NNNKFIYRHNFSYPNLISIDVLVRELEQRIFDIILTNkiDNICISSPGNVNpvSGEIKGLSA- 80
Cdd:cd24069     1 LAIDIGG--TKIAAALiGNGQIIDRRQIPTPRSGTPEALADALASLLADYQGQF--DRVAVASTGIIR--DGVLTALNPk 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  81 -IQGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGEYGYL 159
Cdd:cd24069    75 nLGGLSGFPLADALQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGNLVFITVSTGVGGGLVLNGQLLTGPNGLAGHIGHT 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 160 LNT----KYGNDRyLNVSQSI----GIANLIQsfkKRTNKEVNGEQIYDLYNT-DNDAKTVVEEMIHNTSKLIYNLSFII 230
Cdd:cd24069   155 LADppgpVCGCGR-RGCVEAIasgtAIAAAAS---EILGEPVDAKDVFERARSgDEEAARLIDRAARALADLIADLKATL 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 231 DPDLILIGGAISKNILFINLVNkelktlyKKIGLEPQF---LIKSCKYYNDSNLIGANML 287
Cdd:cd24069   231 DLDCVVIGGSVGLAEGFLERVE-------QYLADEPAIfrvSLEPARLGQDAGLLGAALL 283
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 5-256 2.80e-11

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 62.90  E-value: 2.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   5 LDIGGMSTKIAICDNNNKFIYRhnfsypnlISIDVLV--------RELEQRIFDIILTNKIDNICISSPGNVNPVSGEIK 76
Cdd:cd24064     4 IDLGGTDTKIGIVDENGDILKK--------KTIDTKVengkedviNRIAETVNELIEEMELLGIGIGSPGSIDRENGIVR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  77 GLSAIQGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGEY 156
Cdd:cd24064    76 FSPNFPDWRNFPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNHIIGLTLGTGVGSGVICHGQLLTGYDGIAAEL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 157 GYLL------NTKYGNDRYLN-VSQSIGIANLIQSFKKR-------TNKEVNGEQIYDLY-NTDNDAKTVVEEMIHNTSK 221
Cdd:cd24064   156 GHVIvepngpICGCGNRGCVEaFASATAIIRYARESRKRypdslagESEKINAKHVFDAArKNDPLATMVFRRVVDALAI 235

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1368342677 222 LIYNLSFIIDPDLILIGGAISK--NILFINLVNKELK 256
Cdd:cd24064   236 AIGGFVHIFNPEIIIIGGGISRagSFLLDPIREKTKK 272
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 33-158 6.33e-11

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 62.05  E-value: 6.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  33 NLISIDVLVRELEQRIFDIILTNK--IDNICISSPGNVNPVSGEIKgLSAIQGLETFNFKLTWEPKFKLPVFIDNDANCA 110
Cdd:cd24072    34 TLETPEALIDEIIDCIDRLLKLWKdrVKGIALAIQGLVDSHKGVSL-WSPGAPWRNIEIKYLLEERYGIPVFVENDCNML 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1368342677 111 AIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGEYGY 158
Cdd:cd24072   113 ALAEKWQGELRQSRDFCVINLDYGIGSAIVIDNKLYIGASSGSGEIGH 160
ASKHA_ATPase_ROK_SaXylR-like cd24077
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ...
 94-257 3.01e-10

ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466927 [Multi-domain]  Cd Length: 295  Bit Score: 59.86  E-value: 3.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  94 EPKFKLPVFIDNDANCAAIAELEYGNakNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGEYGYLL------NTKYGND 167
Cdd:cd24077    96 EEKFNVPVYLENEANLSALAERTFSE--DYDNLISISIHSGIGAGIIINNQLYRGYNGFAGEIGHMIivpngkPCPCGNK 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 168 ----RYlnVSQSIgianLIQSFKKRTN-KEVNGEQIYDLYNTDN-DAKTVVEEMIHNTSKLIYNLSFIIDPDLILIGGAI 241
Cdd:cd24077   174 gcleQY--ASEKA----LLKELSEKKGlETLTFDDLIQLYNEGDpEALELIDQFIKYLAIGINNIINTFNPEIIIINSSL 247

                         170
                  ....*....|....*..
gi 1368342677 242 SKNI-LFINLVNKELKT 257
Cdd:cd24077   248 INEIpELLEKIKEQLSS 264
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 1-284 1.76e-09

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 57.62  E-value: 1.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   1 MN-LVLDIGGmsTKI--AICDNNNKFIYRHNFSYPNLISIDVLVRELEQRIFDiiLTNKIDNICISSPGNVNPvsgeiKG 77
Cdd:PRK05082    1 MTtLAIDIGG--TKIaaALVGEDGQIRQRRQIPTPASQTPEALRQALSALVSP--LQAQADRVAVASTGIIND-----GI 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  78 LSAIQ-----GLETFNFKLTWEPKFKLPVFIDNDANCAAIAEleYGNAKNE-KNVVVIVIGTGVGGSLIIDGKIHRGNHF 151
Cdd:PRK05082   72 LTALNphnlgGLLHFPLVQTLEQLTDLPTIALNDAQAAAWAE--YQALPDDiRNMVFITVSTGVGGGIVLNGKLLTGPGG 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 152 FAGEYGYLL----NTKYGNDRYLNVsQSIGIANLIQSFKKRTNKEVNGEQIYDLYNTDN-DAKTVVEEMIHNTSKLIYNL 226
Cdd:PRK05082  150 LAGHIGHTLadphGPVCGCGRRGCV-EAIASGRAIAAAAQGWLAGCDAKTIFERAGQGDeQAQALINRSAQAIARLIADL 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1368342677 227 SFIIDPDLILIGGAISKNILFINLVNKELKTlykkiglEPQFL---IKSCKYYNDSNLIGA 284
Cdd:PRK05082  229 KATLDCQCVVLGGSVGLAEGYLELVQAYLAQ-------EPAIYhvpLLAAHYRHDAGLLGA 282
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 54-266 4.64e-09

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 56.22  E-value: 4.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  54 TNKIDNICISSPGNVNPVSGEIKGLSAIQgLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGT 133
Cdd:cd24075    59 TQRLIAISITLPGLINPKTGVVHYMPHIQ-VKSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHH 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 134 GVGGSLIIDGKIHRGNHFFAGEYGYL----------------LNTKYGNDRYLNVSQsigiaNLIQS--FKKRTNKEVNG 195
Cdd:cd24075   138 GIGAGIIIDGKLFLGQNGNAGEIGHIqieplgerchcgnfgcLETVASNAAIEQRVK-----KLLKQgyASQLTLQDCTI 212

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1368342677 196 EQIYDLYNT-DNDAKTVVEEMIHNTSKLIYNLSFIIDPDLILIGGAISK--NILF--IN--LVNKELKTLYKKIGLEP 266
Cdd:cd24075   213 KDICQAALNgDQLAQDVIKRAGRYLGKVIAILINLLNPQKIIIAGEITQadKVLLpvIKkcIQSQALPDFRQELKIVA 290
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 3-247 5.11e-08

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 53.08  E-value: 5.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   3 LVLDIGGMSTKIAICDNNNKFIYRHNFSYPNLISIDVLVRELEQRI-FDIILTNKIDN---ICISSPGNVNPVSGEIKGL 78
Cdd:cd24074     5 LSIRIGRGYITLALRDLNGRLLAEERYPLPAKDNDPFLDRLLESISeFFSRHQKKLERltaIAITLPGIIDPESGIVHRL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  79 SAIQgLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGEYGY 158
Cdd:cd24074    85 PFYD-IKNLPLGEALEQHTGLPVYVQHDISAWTLAERFFGAAKGAKNIIQIVIDDDIGAGVITDGQLLHAGSSRLGELGH 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 159 LLNTKYGNDRYLN----VSQSIGIANLIQSFKKR---------TNKEVNGEQIYDLYNT-DNDAKTVVEEMIHNTSKLIY 224
Cdd:cd24074   164 TQIDPYGKRCYCGnhgcLETVASIPAILEQANQLleqspdsmlHGQPISIESLCQAALAgDPLAQDIIIQVGRHLGRILA 243

                         250       260
                  ....*....|....*....|....*
gi 1368342677 225 NLSFIIDPDLILIGGAIS--KNILF 247
Cdd:cd24074   244 ILVNLFNPEKILIGSPLNnaAEILF 268
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 99-157 9.38e-08

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 52.55  E-value: 9.38e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1368342677  99 LPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGEYG 157
Cdd:cd24073   103 LPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRGAHGGAGEIG 161
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 5-245 9.45e-08

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 52.34  E-value: 9.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   5 LDIGGMSTKIAICDNNNKFIYRHNFSYPNLISIDVLVRELEQRIFDIILTNKIDN---ICISSPGNVNPVSGEIKGlSAI 81
Cdd:cd24063     5 VDIGGTWIRAGLVDEDGRILLKIRQPTPKTGDPGTVSEQVLGLIETLLSKAGKDSiegIGVSSAGPLDLRKGTIVN-SPN 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  82 QGLETFNFKLTWEPKFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGKIHRGNHFFAGEYGYLLN 161
Cdd:cd24063    84 IKGKEIPLVEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYITISTGIGGGVIVDGRLLLGKNGNAAEVGHLVV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 162 TKYGNDR----YLNVSQSI----GIANLIQSFKKRTNKE------------VNGEQIYDLYNTDND-AKTVVEEMIHNTS 220
Cdd:cd24063   164 DTESGLKcgcgGYGHWEAFasgrGIPRFAREWAEGFSSRtslklrnpggegITAKEVFSAARKGDPlALKIIEKLARYNG 243

                         250       260
                  ....*....|....*....|....*
gi 1368342677 221 KLIYNLSFIIDPDLILIGGAISKNI 245
Cdd:cd24063   244 RGIANVINAYDPELIVIGGSVFNNN 268
PRK09557 PRK09557
fructokinase; Reviewed
 1-245 2.81e-06

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 47.71  E-value: 2.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   1 MNLVLDIGGMSTKIAICDNNNKFIYRHNFSYP------NLISIDVLVRELEQrifdiiLTNKIDNICISSPGNVNPVSGE 74
Cdd:PRK09557    1 MRIGIDLGGTKIEVIALDDAGEELFRKRLPTPrddyqqTIEAIATLVDMAEQ------ATGQRGTVGVGIPGSISPYTGL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  75 IKglsaiqgletfNFKLTW---EP-------KFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGK 144
Cdd:PRK09557   75 VK-----------NANSTWlngQPldkdlsaRLNREVRLANDANCLAVSEAVDGAAAGKQTVFAVIIGTGCGAGVAINGR 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 145 IHRGNHFFAGEYGY--LLNTKYGNDRYLN-----------VSQSIGIANLIQSFKKRTNKEVNGEQIYDLYNT-DNDAKT 210
Cdd:PRK09557  144 VHIGGNGIAGEWGHnpLPWMDEDELRYRNevpcycgkqgcIETFISGTGFATDYRRLSGKALKGSEIIRLVEEgDPVAEL 223

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1368342677 211 VVEEMIHNTSKLIYNLSFIIDPDLILIGGAISkNI 245
Cdd:PRK09557  224 AFRRYEDRLAKSLAHVINILDPDVIVLGGGMS-NV 257
PRK13310 PRK13310
N-acetyl-D-glucosamine kinase; Provisional
 5-242 7.54e-06

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 183967 [Multi-domain]  Cd Length: 303  Bit Score: 46.52  E-value: 7.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   5 LDIGGmsTKIAICDNNNKF--IYRHNF-----SYPNLIS-IDVLVRELEQRiFDIILTnkidnICISSPGNVNPVSG--E 74
Cdd:PRK13310    5 FDIGG--TKIELGVFNEKLelQWEERVptprdSYDAFLDaVCELVAEADQR-FGCKGS-----VGIGIPGMPETEDGtlY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  75 IKGLSAIQG------LETfnfKLTWEpkfklpVFIDNDANCAAIAEleygnAKNEKNVVVIVIGTGVGG-----SLIIDG 143
Cdd:PRK13310   77 AANVPAASGkplradLSA---RLGRD------VRLDNDANCFALSE-----AWDDEFTQYPLVMGLILGtgvggGLVFNG 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 144 KIHRGNHFFAGEYGY----------------LLNTKYGN----DRYLNvsqSIGIANLIQSFKkrtNKEVNGEQIYDLYN 203
Cdd:PRK13310  143 KPISGRSYITGEFGHmrlpvdaltllgwdapLRRCGCGQkgciENYLS---GRGFEWLYQHYY---GEPLQAPEIIALYY 216

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1368342677 204 tDNDAKTV--VEEMIHNTSKLIYNLSFIIDPDLILIGGAIS 242
Cdd:PRK13310  217 -QGDEQAVahVERYLDLLAICLGNILTIVDPHLVVLGGGLS 256
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 96-287 4.32e-04

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 40.99  E-value: 4.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677  96 KFKLPVFIDNDANCAAIAELEYGNAKNEKNVVVIVIGTGVGGSLIIDGK----------------IHRGNHFFAGeygyl 159
Cdd:cd24067    94 AFPVPVGFDTDVNAAALAEYRWGAAKGLDSLAYITVGTGIGVGLVVNGKpvhgllhpemghirvpRHPDDDGFPG----- 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677 160 lNTKYGNDRYLNVSQSIGIAnliqsfkKRTNKEvnGEQIydlynTDNDAKTVVEEmiHNTSKLIYNLSFIIDPDLILIGG 239
Cdd:cd24067   169 -VCPFHGDCLEGLASGPAIA-------ARWGIP--AEEL-----PDDHPAWDLEA--YYLAQACANLTLTLSPERIVLGG 231

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1368342677 240 AISKNILFINLVNKELKTL---YKKIGLEPQFL---IKSCKYYNDSNLIGANML 287
Cdd:cd24067   232 GVMQRPGLFPRIREKFRKLlngYLEVPRLLPDIdeyIVPPALGNDAGILGALAL 285
ASKHA_NBD_eukNAGK-like cd24007
nucleotide-binding domain (NBD) of the eukaryotic-type N-acetylglucosamine kinase (NAGK) ...
 3-116 2.23e-03

nucleotide-binding domain (NBD) of the eukaryotic-type N-acetylglucosamine kinase (NAGK) family; The eukaryotic-type NAGK-like family includes a group of proteins similar to eukaryotic N-acetyl-D-glucosamine kinases, such as Vibrio cholerae glucosamine kinase GspK, Sulfurisphaera tokodaii ATP-dependent hexokinase (StHK), Thermoplasma acidophilum 2-dehydro-3-deoxygluconokinase (KdgK) and Clostridium acetobutylicum N-acetylmuramic acid/N-acetylglucosamine kinase (MurK). NAGK (EC 2.7.1.59), also called GlcNAc kinase, converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. It is involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. NAGK also has ManNAc kinase activity. GspK (EC 2.7.1.8), also called GlcN kinase, acts as ATP-dependent kinase, which is specific for glucosamine. StHK is a novel hexokinase that can phosphorylate not only glucose but also GlcNAc, glucosamine, and mannose. KdgK (EC 2.7.1.45), also called 2-keto-3-deoxy-D-gluconate kinase, or KDG kinase, catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). It is specific for KDG. MurK (EC 2.7.1.-/EC 2.7.1.59), also known MurNAc/GlcNAc kinase, or murein sugar kinase, catalyzes the ATP-dependent phosphorylation of both cell wall (peptidoglycan) amino sugars, N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), at the 6-hydroxyl group. The eukaryotic-type N-acetylglucosamine kinase (NAGK) family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466857 [Multi-domain]  Cd Length: 295  Bit Score: 38.83  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1368342677   3 LVLDIGGMSTKIAICDNNNKFIYRHNFSYPNLISIDvlVRELEQRIFDIIltnkidNICISSPGNVNPVSGEIKGLSaiq 82
Cdd:cd24007     2 LGVDGGGTKTRAVLADEDGKILGRGKGGPSNPASVG--IEEAKENLKEAV------REALSQAGSLGEIDAICLGLA--- 70

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1368342677  83 GLETFNFKLTWEPKFK-----LPVFIDNDANCAAIAELE 116
Cdd:cd24007    71 GIDSEEDRERLRSALKelflsGRIIIVNDAEIALAAALG 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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