|
Name |
Accession |
Description |
Interval |
E-value |
| lacY |
PRK09528 |
galactoside permease; Reviewed |
1-420 |
0e+00 |
|
galactoside permease; Reviewed
Pssm-ID: 236549 Cd Length: 420 Bit Score: 589.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 1 MNSASTHKNPDFWIFGLFFFLYFFIMATCFPFLPVWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLI 80
Cdd:PRK09528 1 MATMYYLKNPNYWIFSLFFFFFFFIWSSWFSFFPIWLHDINGLSGTDTGIIFSANSLFALLFQPLYGLISDKLGLKKHLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 81 WSISLLLVFFAPFFLYVFAPLLRFNIWAGALTGGVFIGFVFSAGAGAIEAYIERVSRSRGFEYGKARMFGCLGWALCATM 160
Cdd:PRK09528 81 WIISGLLVLFGPFFIYVFAPLLQYNILLGAIVGGIYLGFGFLAGAGAIEAYIERVSRRSGFEYGRARMWGSLGWALCAFI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 161 AGMLFNVDPSLVFWMGSGGALLLLLLLFLARPSTSQTAMVMNTLGANSSLISTRMVFSLFRMRQMWMFVLYTIGVACVYD 240
Cdd:PRK09528 161 AGILFNINPQINFWLGSGSALILLVLLFFAKPDAPSTAKVANALGANASAVSLKDALALLKLPKFWFLVLYVIGVACFYD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 241 VFDQQFATFFRSFFDTPQAGIKAFGFATTAGEICNAIIMFCTPWIIHRIGAKNTLLVAGGIMTIRITGSAFATTATEVVI 320
Cdd:PRK09528 241 VFDQQFPNFFASFFATPEQGTRVFGYLNSFQVFLEALIMFFAPFIINRIGAKNALLLAGTIMAVRIIGSGFATGPLEVSI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 321 LKMLHALEVPFLLVGAFKYITAVFDTRLSATVYLIGFQFSKQLAAILLSTFAGHLYDRMGFQNTYFVLGMIALTVTVISA 400
Cdd:PRK09528 321 LKLLHAFEVPFLLVGVFKYITLNFDVRLSATIYLVGFQFAKQLGAVFLSTLAGNLYDSIGFQGTYLILGGIVLLFTLISV 400
|
410 420
....*....|....*....|
gi 1359420346 401 FTLSSSRGSVHPSVEKAPAA 420
Cdd:PRK09528 401 FTLSGDRELSLLRRQVPEAA 420
|
|
| LacY_symp |
pfam01306 |
LacY proton/sugar symporter; This family is closely related to the sugar transporter family. |
4-415 |
0e+00 |
|
LacY proton/sugar symporter; This family is closely related to the sugar transporter family.
Pssm-ID: 396050 Cd Length: 413 Bit Score: 581.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 4 ASTHKNPDFWIFGLFFFLYFFIMATCFPFLPVWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIWSI 83
Cdd:pfam01306 1 MYPLKNTNFWMFGLFFFFYFFIMSAYFPFFPIWLHDVNHLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLRKHLLWCI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 84 SLLLVFFAPFFLYVFAPLLRFNIWAGALTGGVFIGFVFSAGAGAIEAYIERVSRSRGFEYGKARMFGCLGWALCATMAGM 163
Cdd:pfam01306 81 TGLLVLFAPFFIYVFGPLLQSNILVGAIVGGVYLGFVFSAGAGAIEAYIEKVSRRSNFEYGKARMFGCVGWALCASIAGI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 164 LFNVDPSLVFWMGSGGALLLLLLLFLARPSTSQTAMVMNTLGANSSLISTRMVFSLFRMRQMWMFVLYTIGVACVYDVFD 243
Cdd:pfam01306 161 LFSIDPQIVFWLGSGFALILALLLMFAKPDKSSSAIVADALGANKSAFSLRLALELFRMPKFWVFVLYVVGVACVYDVFD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 244 QQFATFFRSFFDTPQAGIKAFGFATTAGEICNAIIMFCTPWIIHRIGAKNTLLVAGGIMTIRITGSAFATTATEVVILKM 323
Cdd:pfam01306 241 QQFANFFTSFFATPQQGTRVFGYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRILGSSFATTALEVVILKM 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 324 LHALEVPFLLVGAFKYITAVFDTRLSATVYLIGFQFSKQLAAILLSTFAGHLYDRMGFQNTYFVLGMIALTVTVISAFTL 403
Cdd:pfam01306 321 LHMFEVPFLLVGCFKYITSQFDVRLSATIYLIGFQFSKQLAMILLSTLAGIMYDSIGFQGAYLVLGGIVLSFTLISVFTL 400
|
410
....*....|...
gi 1359420346 404 SSSRG-SVHPSVE 415
Cdd:pfam01306 401 SGSGPqILLPRPV 413
|
|
| 2A0105 |
TIGR00882 |
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
9-404 |
0e+00 |
|
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 211613 Cd Length: 396 Bit Score: 570.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 9 NPDFWIFGLFFFLYFFIMATCFPFLPVWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIWSISLLLV 88
Cdd:TIGR00882 1 NTNFWMFGLFFFLYFFIMSAYFPFFPIWLHDVNGLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLKKHLLWIISGLLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 89 FFAPFFLYVFAPLLRFNIWAGALTGGVFIGFVFSAGAGAIEAYIERVSRSRGFEYGKARMFGCLGWALCATMAGMLFNVD 168
Cdd:TIGR00882 81 LFAPFFIYVFGPLLQSNILVGAIVGGLYLGFVFSAGAGAIEAYIEKVSRNSNFEYGKARMFGCVGWALCASIAGILFSID 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 169 PSLVFWMGSGGALLLLLLLFLARPSTSQTAMVMNTLGANSSLISTRMVFSLFRMRQMWMFVLYTIGVACVYDVFDQQFAT 248
Cdd:TIGR00882 161 PQIVFWLGSGFALILMLLLMFAKPKAPSSATVANALGANASAFSLKLALELFRQRKFWMFVLYVVGVACVYDVFDQQFAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 249 FFRSFFDTPQAGIKAFGFATTAGEICNAIIMFCTPWIIHRIGAKNTLLVAGGIMTIRITGSAFATTATEVVILKMLHALE 328
Cdd:TIGR00882 241 FFTSFFATPQQGTRVFGYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRIIGSSFATTALEVVILKMLHAFE 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1359420346 329 VPFLLVGAFKYITAVFDTRLSATVYLIGFQFSKQLAAILLSTFAGHLYDRMGFQNTYFVLGMIALTVTVISAFTLS 404
Cdd:TIGR00882 321 VPFLLVGCFKYITSQFDVRLSATIYLIGFQFAKQLAMIFLSTLAGNMYDSIGFQGAYLVLGCIVLLFTLISVFTLS 396
|
|
| MFS_LacY |
cd06172 |
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ... |
12-403 |
2.14e-178 |
|
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340862 [Multi-domain] Cd Length: 389 Bit Score: 502.92 E-value: 2.14e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 12 FWIFGLFFFLYFFIMATCFPFLPVWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIWSISLLLVFFA 91
Cdd:cd06172 1 YWKFSLFFFLFFFIWSASFSFFPIWLTQINHLSGSETGIVFSANSLFALLFQPVYGLISDKLGLKKHLLWFISGLLVLFG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 92 PFFLYVFAPLLRFNIWAGALTGGVFIGFVFSAGAGAIEAYIERVSRSRGFEYGKARMFGCLGWALCATMAGMLFNVDPSL 171
Cdd:cd06172 81 PFFIFVYGPLLQSNILLGAIVGGIYLGFAFLAGCGAIESYIERVSRRFNFEYGRARMWGSLGWALAAFFAGILFNINPNI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 172 VFWMGSGGALLLLLLLFLARPSTSQTAMVMntlGANSSLISTRMVFSLFRMRQMWMFVLYTIGVACVYDVFDQQFATFFR 251
Cdd:cd06172 161 NFWLGSGFALILLLLLLFAKPEDSDTAAAA---GANASSVSLKDVLELFRMPKFWFFILFVIGVSCFYDVFDQQFPPYFT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 252 SFFDTPQAGIKAFGFATTAGEICNAIIMFCTPWIIHRIGAKNTLLVAGGIMTIRITGSAFATTATEVVILKMLHALEVPF 331
Cdd:cd06172 238 SLFATPEQGNRVFGYLNSAQVFLEAGMMFLAPLIVNRIGAKNGLLLAGTIMAVRIIGSGLATSPLEISILKLLHAFEVPL 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1359420346 332 LLVGAFKYITAVFDTRLSATVYLIGFQFSKQLAAILLSTFAGHLYDRMGFQNTYFVLGMIALTVTVISAFTL 403
Cdd:cd06172 318 LLVSIFKYITSHFDTRLSATLYLVGFQFAKQLGAVVLSPLAGNLYDSIGFQQTYLVLGGIVLVFTLISVFTL 389
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
23-401 |
6.33e-18 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 84.94 E-value: 6.33e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 23 FFIMATCFPFLPVWLSDvVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIW-SISLLLVFFAPFFLYVFAPL 101
Cdd:cd17335 10 FAALGSLLPFLSVYLKQ-LGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLlSLLAAVLFFLSLFFVAQIFW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 102 LRFNIWAGAltggvfiGFVFSAGAGAIEAYIERVSRSRGFEYGKARMFGCLGWALCATMAGMLFN-----VDPSLVFWMG 176
Cdd:cd17335 89 LLLLLVILG-------AFFSAPVVPLVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDrsstyKNYTIAFYVF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 177 SGGALLLLLLLFLARPSTSQTAMVMNTLGansslistrmVFSLFRMRQMWMFVLytigVACVYDVFDQQFATFFRSFFDT 256
Cdd:cd17335 162 AVLMLLALLLALKFPFRPKHPEPNENTGG----------LLALLRNPRVLAFLL----VAFLMGFGHGLIYSFLFWHLQD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 257 PQAGIKAFGFATTAGEICNAIIMFCTPWIIHRIGAKNTLLVAGGIMTIRITGSAFATTATEVVILKMLHALEVPFLLVGA 336
Cdd:cd17335 228 LGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAA 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1359420346 337 FKYITAVFDTRLSATV----YLIGFQFSKQLAAILlstfAGHLYDRMGFQNTYFVLGMIALTVTVISAF 401
Cdd:cd17335 308 VSYASAAAPPGLRATAqgllQGLYFGLGGGLGSLI----GGYLYEAFGARTTFRFFAIAALAGLLAFFL 372
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
30-412 |
1.09e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 78.38 E-value: 1.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 30 FPFLPVWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKnliWSISLLLVFFAPFFLYVFAPLLRFNIWAG 109
Cdd:COG2223 24 WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRR---VLLIGLLLLGIGLLLLALAVSYWLLLLLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 110 ALtGGVFIGFVFSAGAGAIEAYIERvsRSRGFEYGKARMFGCLGWALCATMAGMLFN-VDPSLVFWMGSGGALLLLLLLF 188
Cdd:COG2223 101 LL-LGIGGGGSFAVGIALVSKWFPP--DRRGLALGLAAGGGNLGAAVAAFLAPLLIAaFGWRNAFLILGILLLVVAVLAW 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 189 LARPSTSQTAmvmntlgANSSLISTRMVFSLFRMRQMWMFVLYTIGVACVYDVFDQQFATFFRSFFDTPQAgikAFGFAT 268
Cdd:COG2223 178 LFLRDPPAGA-------AAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAA---TAGLLA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 269 TAGEICNAIIMFCTPWIIHRIGAKNTLLVAGGIMTIRITGSAFAT-TATEVVILKMLHALEVPFLLVGAFKYITAVFDTR 347
Cdd:COG2223 248 ALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTK 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1359420346 348 LSATVYLIGFqFSKQLAAILLSTFAGHLYDRMG-FQNTYFVLGMIALTVTVISAFTLSSSRGSVHP 412
Cdd:COG2223 328 NAGAVYGLVG-AAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
30-401 |
1.79e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 65.29 E-value: 1.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 30 FPFLPVWLSDVvGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIWSislLLVFFAPFFLYVFAPLLRFNIwAG 109
Cdd:cd17325 16 IPILPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLG---LLLLAVSTLLFAFATSYWQLL-LA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 110 ALTGGVFIGFVFSAGAGAIEAYIERvsRSRGFEYGKARMFGCLGWALCATMAGMLFNV-DPSLVFWMGSGGALLLLLLLF 188
Cdd:cd17325 91 RFLQGLASAAVWPAAMALIADIAPP--EERGRAMGIFSSAIGLGFLIGPLLGGLLADAlGYRAPFLVCAALALLALVLAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 189 LARPSTSQTAmvmnTLGANSSLISTRMVFSLFRMRQMWMFVLYTIGVACVYDVFDQQFATFFRSFFDTPQAGIkafGFAT 268
Cdd:cd17325 169 LLLPEPRPPP----NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI---GLLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 269 TAGEICNAIIMFCTPWIIHRIGAKNTLLVAGGIMTIRITGSAFATTATEVVILKMLHALEVPFLLVGAFKYITAVFDTRL 348
Cdd:cd17325 242 GAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1359420346 349 SATVYLIgFQFSKQLAAILLSTFAGHLYDRMGFQNTYFVLGMIALTVTVISAF 401
Cdd:cd17325 322 RGTAMGL-FNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
31-401 |
5.78e-11 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 63.60 E-value: 5.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 31 PFLPVWLSDVvGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIWSISLLLVFFAPFFLyvfapllrFNIWAGA 110
Cdd:cd06174 17 PLLPALLQSF-GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF--------APSFWLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 111 LTGGVFIGFVFSAGAGAIEAYIERVS--RSRGFEYGKARMFGCLGWALCATMAGMLFNVDPS---LVFWMGSGGALLLLL 185
Cdd:cd06174 88 LLGRFLLGLGSGLIDPAVLALIADLFpeRERGRALGLLQAFGSVGGILGPLLGGILASSLGFgwrAVFLIAAALALLAAI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 186 LLFLARPSTSQTAmvmntLGANSSLISTRMVFSLFRMRQMWMFVLYTIGVACVYDVFDQQFATFFRSFFDTPQAGIKAFG 265
Cdd:cd06174 168 LLLLVVPDPPESA-----RAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 266 FATTAGEICNAIIMFCTPWIIHR-IGAKNTLLVAGGIMTIRITGSAFATTATEVVILKMLHALEVPFLLVGAFKYITAVF 344
Cdd:cd06174 243 LLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELF 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1359420346 345 DTRLSATVYLIgFQFSKQLAAILLSTFAGHLYDRMGFQNTYFVLGMIALTVTVISAF 401
Cdd:cd06174 323 PPEIRGTAFGL-LNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
8-178 |
6.74e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 60.28 E-value: 6.74e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 8 KNPDFWIFGLFFFLYFFIMATCFPFLPVWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIWSISLLL 87
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 88 VFFAPFFLYVFAPLLrfniWAGALTGGVFIGFVFSAGAGAIEAYIERvsRSRGFEYGKARMFGCLGWALCATMAGMLF-N 166
Cdd:cd17325 277 VALLLLPLATSFWLL----LLLLALLGLGLGLVFPATLALLADIVPP--EGRGTAMGLFNTAFSLGMVLGPLLGGFLYdA 350
|
170
....*....|..
gi 1359420346 167 VDPSLVFWMGSG 178
Cdd:cd17325 351 FGFATPFLAAAA 362
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
30-178 |
1.51e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 56.08 E-value: 1.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 30 FPFLPVWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIWSISLLLVFFAPFFLYVFAPLlrfnIWAG 109
Cdd:cd17329 19 WPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWL----FAIA 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1359420346 110 AltggVFIGFVFSAGAGAIEAYIERVSRSRGFEYGKA--RMFGCLGWALCATMAGMLFNVDPSLVFWMGSG 178
Cdd:cd17329 95 L----VLTGFGGGLFEPASEAMIADVTTPENRTRAFSllYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAV 161
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-352 |
1.06e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 53.44 E-value: 1.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 1 MNSASTHKNPDFWIFGLFFFLYFFIMATCFPFLPvWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLI 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 81 WSislLLVFFAPFFLYVFAPLLRFNIWAGALTgGVFIGFVFSAGAGAIEAYIERVSRSRGFeyGKARMFGCLGWALCATM 160
Cdd:COG2814 80 LG---LLLFALGSLLCALAPSLWLLLAARFLQ-GLGAGALFPAALALIADLVPPERRGRAL--GLLGAGLGLGPALGPLL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 161 AGMLFN-VDPSLVFWMGSGGALLLLLLLFLARPSTSQTAMVMntlganssliSTRMVFSLFRMRQMWMFVLYTIGVACVY 239
Cdd:COG2814 154 GGLLADlFGWRWVFLVNAVLALLALLLLLRLLPESRPAARAR----------LRGSLRELLRRPRLLLLLLLAFLLGFGF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 240 DVFDQQFATFFRSFFDTPQAGIkafGFATTAGEICNAIIMFCTPWIIHRIGAKNTLLVAGGIMTIRITGSAFATTATEVV 319
Cdd:COG2814 224 FALFTYLPLYLQEVLGLSASAA---GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLL 300
|
330 340 350
....*....|....*....|....*....|...
gi 1359420346 320 ILKMLHALEVPFLLVGAFKYITAVFDTRLSATV 352
Cdd:COG2814 301 LALFLLGFGFGLLFPLLQALVAELAPPEARGRA 333
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
32-321 |
1.71e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.98 E-value: 1.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 32 FLPVWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKK----------NLIWSISLLLVFFAPFFLYVFApl 101
Cdd:COG2211 32 YLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwiligAIPLALSFVLLFTAPDLSPTGK-- 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 102 lrfniWAGALTGGVFIGFVFSAGAGAIEAYIERVSRS---RGFEYGKARMFGCLGWALCATMAGMLFNV----DPSLVFW 174
Cdd:COG2211 110 -----LIYALVTYLLLGLAYTLVNIPYSALGAELTPDyeeRTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdAALGYRL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 175 MGSGGALLLLLLLFLARPSTSQTAMVmntlgANSSLISTRMVFSLFRMRQMWMFVLYTIGVACVYDVFDQQFATFFRSFF 254
Cdd:COG2211 185 TALIFAVLGLLAFLLTFFGTKERPVP-----EEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL 259
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1359420346 255 DTPQAgikAFGFATTAGEICNAIIMFCTPWIIHRIGAKNTLLVAGGIMTIRITGSAFATTATEVVIL 321
Cdd:COG2211 260 GLSAA---LVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLL 323
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
30-327 |
3.39e-07 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 51.86 E-value: 3.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 30 FPFLPVWLSDVvGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIwsiSLLLVFFAPFFLYVFAPLLRFNIWAG 109
Cdd:pfam12832 19 LPYWGLYLRSI-GLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVV---RLASILAAVLFLSVLFIPISLTFWWL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 110 ALTGGVFiGFVFSAGAGAIEAYIERVSRSRGFEYGKARMFGCLGWALCATMAGMLFN-----VDPSLVFWMgSGGALLLL 184
Cdd:pfam12832 95 ALLVVLF-SFFWNAILPQFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDhysvgLLPSVLFYL-FAALMLLS 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 185 LLLFLARPSTSqtamvmntlgANSSLISTRMVFSLFRMRQMWMFVLytigVACVYDVFDQQFATFFRSFFDTPQAGIKAF 264
Cdd:pfam12832 173 LLLPLAPPEME----------YESKGGSKAVFWNLLKQPEVIIFFL----AAFLLGFSHGPFYTFLFLYLENLGASNTLL 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1359420346 265 GFATTAGEICNAIIMFCTPWIIHRIGAKNTLLVAGGIMTIRITG-SAFATTATEVVILKMLHAL 327
Cdd:pfam12832 239 GALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLyAFFVENPWLVLPIQFLHAI 302
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
30-321 |
8.11e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.49 E-value: 8.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 30 FPFLPVWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKnlIWSISLLLVFFAPFFLYVFAPLlrFNIWAG 109
Cdd:pfam07690 16 GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRR--VLLIGLLLFALGLLLLLFASSL--WLLLVL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 110 ALTGGVFIGFVFSAGAGAIEAYIERvsRSRGFEYGKARMFGCLGWALCATMAGMLF-NVDPSLVFWMGSGGALLLLLLLF 188
Cdd:pfam07690 92 RVLQGLGAGALFPAALALIADWFPP--EERGRALGLVSAGFGLGAALGPLLGGLLAsLFGWRAAFLILAILSLLAAVLLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 189 LARPSTSQTamvmNTLGANSSLISTRMVFSLFRMRQMWMFVLYTIGVACVYDVFDQQFATFFRSFFDTPQAGIKAFGFAT 268
Cdd:pfam07690 170 LPRPPPESK----RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGG 245
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1359420346 269 TAGeicnAIIMFCTPWIIHRIGAKNTLLVAGGIMTIRITGSAFATTATEVVIL 321
Cdd:pfam07690 246 LLG----AIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWL 294
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
25-401 |
1.78e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.41 E-value: 1.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 25 IMATC--FPFLPVWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIWSISLLLVF-FAPFFLYVFAPL 101
Cdd:cd17473 12 VMAGAaiAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGgVAGLFLDSLYAL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 102 LrfniwAGALTGGVFIGFVFSAGAGAIEAYIERVSRSRGFeyGKARMFGCLGWALCATMAGMLFNVDPSLVFWMGSGGAL 181
Cdd:cd17473 92 L-----ASRALLGIGVAGIMTLATALIGDYFEGEERAKML--GLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 182 LLLLLLFLARPSTSQTAMVMNTLGANSSLISTRMVFSLFRMRQMWMFVLYTIGVacvydvfdqQFATFFRSFFDTPQAGI 261
Cdd:cd17473 165 VLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPI---------QLPFLLQERGGGSAALI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 262 kafGFATTAGEICNAIIMFCTPWIIHRIGAKNTLLVAGGIMTIRITGSAFATTATEVVILKMLHALEVPFLLVGAFKYIT 341
Cdd:cd17473 236 ---GLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAM 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1359420346 342 AVFDTRLS--ATVYLIGFQFSKQLAAILLSTFAGHLYdrMGFQNTYFVLGMIALTVTVISAF 401
Cdd:cd17473 313 SLVPPELRgrAMGIVTSAFFLGQFLSPLVLGPLVNLT--GGLSGAFLILGVLALVLAIVLLL 372
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
8-141 |
3.02e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.74 E-value: 3.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 8 KNPDFWIFGLFFFLYFFIMATCFPFLPVWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIWSISLLL 87
Cdd:COG2814 205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1359420346 88 VFFAPFFLYVFAPLLrfniWAGALTGGVFIGFVFSAGAGAIEAYIERVSRSRGF 141
Cdd:COG2814 285 LGLLLLALAGSLWLL----LLALFLLGFGFGLLFPLLQALVAELAPPEARGRAS 334
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-139 |
4.38e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 45.26 E-value: 4.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 8 KNPDFWIFGLFFFLYFFIMATCFPFLPVWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIWSISLLL 87
Cdd:COG2223 203 RDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMA 282
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1359420346 88 VFFAPFFLYVFApllrfniWAGALTGGVFIGFVFSAGAGAIEAYIERVSRSR 139
Cdd:COG2223 283 LGLLLLALALGS-------LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTK 327
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
28-401 |
4.50e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 45.25 E-value: 4.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 28 TCFPFLPVWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKK-----NLIWSISLLLVFFAPFFLYVFApll 102
Cdd:COG2271 27 SNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRvlaigLLLWGLATLLFGFATSFWQLLL--- 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 103 rfniwaGALTGGVFIGFVFSAGAGAIEAYIERvsRSRGFEYGKARMFGCLGWALCATMAGMLF-NVDPSLVFWMGSGGAl 181
Cdd:COG2271 104 ------LRFLLGLGEAGFFPAALKLIAEWFPP--KERGRALGIFNAGGPLGGALAPPLLGWLLaAFGWRAAFLILGLPG- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 182 llllllflarpstsqtamvmntlgansslistrMVFSLFRMrqmWMFVLYTIGVACVYDVFDQQFATFFRSFFDTPQAGI 261
Cdd:COG2271 175 ---------------------------------LLLALLRF---WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 262 kafGFATTAGEICNAIIMFCTPWIIHRIGA--KNTLLVAGGIMTIRITGSAFATTATEVVILKMLHALEVPFLLVGAFKY 339
Cdd:COG2271 219 ---GLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWAL 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1359420346 340 ITAVFDTRLSATVYLIGFQFSkQLAAILLSTFAGHLYDRMGFQNTYFVLGMIALTVTVISAF 401
Cdd:COG2271 296 AAELFPKKARGTASGLVNTFG-FLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
8-164 |
7.40e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.89 E-value: 7.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 8 KNPDFWIFGLFFFLYFFIMATCFPFLPVWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIWSISLLL 87
Cdd:COG2211 226 KNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 88 VFFAPFFLYVFAPLLRFNIWA--GALTGGVFIGFVFSAGAGAIEA-YIERVSRSRGFEYGKARMFGCLGWALCATMAGML 164
Cdd:COG2211 306 LGLLLLFFLGPGNLWLLLVLAalAGIGLGAILVLPWAMLADVVDYdEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
32-130 |
7.54e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 44.83 E-value: 7.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 32 FLPVWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIWSISLLLVFFAPFFlyvfaPLLRFNIWAGAL 111
Cdd:cd17369 250 FALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFF-----WLLDTGSTWLIV 324
|
90
....*....|....*....
gi 1359420346 112 TGGVFIGFVFSAGAGAIEA 130
Cdd:cd17369 325 LAAVVVLGVLHGMMYGPQA 343
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
30-95 |
7.68e-04 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 41.57 E-value: 7.68e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1359420346 30 FPFLPVWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIWSISLLLVFFAPFFL 95
Cdd:cd17366 213 LSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFL 278
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-180 |
1.03e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.01 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 12 FWIFGLFFFLYFFIMATCFPFLPVWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIWSISLLLVFFA 91
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 92 PFFLYVFAPLlrfniwAGALTGGVFIGFVFSAGAGAIEAYIERV--SRSRGFEYGKARMFGCLGWALCATMAGMLF-NVD 168
Cdd:COG2271 262 LLLLALLPSP------ALAIALLFLAGFGLGGAFGLLWALAAELfpKKARGTASGLVNTFGFLGGALGPLLVGYLLdATG 335
|
170
....*....|..
gi 1359420346 169 PSLVFWMGSGGA 180
Cdd:COG2271 336 YQAAFLLLAALA 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
8-156 |
2.51e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.71 E-value: 2.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 8 KNPDFWIFGLFFFLYFFIMATcFPFLPVWLsDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIWSISLLL 87
Cdd:pfam07690 199 RDPVLWLLLALLLFGFAFFGL-LTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLI 276
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1359420346 88 VFFAPFFLYVFAPLLRFNIWAGALTgGVFIGFVFSAGAGAIEAYIERvsRSRGFEYGKARMFGCLGWAL 156
Cdd:pfam07690 277 LAALGLLLLSLTLSSLWLLLALLLL-GFGFGLVFPALNALVSDLAPK--EERGTASGLYNTAGSLGGAL 342
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
32-116 |
3.00e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 39.41 E-value: 3.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 32 FLPVWLSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIW------SISLLLVFFAPFFlyvFAPllrfN 105
Cdd:cd17337 230 FMPLYFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVRWfggvgcAISTLLFYYVPQL---FGH----N 302
|
90
....*....|.
gi 1359420346 106 IWAGALTGGVF 116
Cdd:cd17337 303 YWAALIAAILF 313
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
37-401 |
8.64e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 38.30 E-value: 8.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 37 LSDVVGLSKTDTGIVFSCLSLFAISFQPLLGVISDRLGLKKNLIWSislLLVFFAPFFLYVFAPllrfnIWAGALTGGVF 116
Cdd:COG0738 34 LKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLG---LLLMALGLLLFALAP-----SYPLLLLALFL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 117 IGFVFSAGAGAIEAYIERVSRsrgfEYGKARM-----FGCLGWALCATMAGMLF--NVDPSLVFWMGSGGALLLLLLLFL 189
Cdd:COG0738 106 LGLGLGLLDVAANPYVAALGP----ETAASRLnllhaFFSLGALLGPLLGGLLIllGLSLSWHLPYLILAVLLLLLALLF 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 190 ARpstsqTAMVMNTLGANSSLISTRMVFSLFRMRQMWMFVLYTIGVACVYDVFDQQFATFFRSFFDTPQAgikAFGFATT 269
Cdd:COG0738 182 LR-----SKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEA---TAALGLS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 270 AGEICNAIIMFCTPWIIHRIGAKNTLLVAGGIMTIRITGSAFATTATEVVILkmlhalevpFLLVGAFkyITAVFDTRLS 349
Cdd:COG0738 254 LFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIG---------LALVGLG--LSLMFPTIFS 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1359420346 350 ATVYLIGFQFSKQLAAILLSTFA---------GHLYDRMGFQNTYFVLGMIALTVTVISAF 401
Cdd:COG0738 323 LALDGLGKRTAAAVSAVLIMGIVggaigppliGFLADAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
263-421 |
9.24e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 37.93 E-value: 9.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 263 AFGFATTAGEICNAIIMFCTPWIIHRIGAKNTLLVAGGIMTIRITGSAFATTATEVVILKMLHALEVPFLLVGAFKYITA 342
Cdd:COG2807 54 QAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKR 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1359420346 343 VFDTRLSA--TVYLIGFqfskQLAAILLSTFAGHLYDRMGFQNTYFVLGMIALTVTVISAFTLSSSRGSVHPSVEKAPAA 420
Cdd:COG2807 134 WFPDRVGLmtGLYTAAM----GLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLR 209
|
.
gi 1359420346 421 H 421
Cdd:COG2807 210 S 210
|
|
| |
