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Conserved domains on  [gi|1353832897|gb|AVK08478|]
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ribonucleotide reductase, small chain family protein [Pseudomonas paraeruginosa]

Protein Classification

ribonucleotide-diphosphate reductase subunit beta( domain architecture ID 10792892)

ribonucleotide-diphosphate reductase subunit beta catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides, providing the precursors necessary for DNA synthesis

CATH:  1.10.620.20
EC:  1.17.4.1
Gene Ontology:  GO:0009263|GO:0006260|GO:0046872|GO:0004748|GO:0005971
PubMed:  34461093|16756507
SCOP:  4000846

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK07209 PRK07209
ribonucleotide-diphosphate reductase subunit beta; Validated
 51-415 0e+00

ribonucleotide-diphosphate reductase subunit beta; Validated


:

Pssm-ID: 235968  Cd Length: 369  Bit Score: 773.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897  51 SDAVARAKKALNDLDIQEGLDDLEGSAARVQVGDKQMINARADLNQLVPFKYDWAWQKYLDGCANHWMPQEVNMNADIAL 130
Cdd:PRK07209    5 DDEVKAVMPALDALAVATGLEELEGGAARVNVDDKRIINCRADVNQLVPFKYKWAWEKYLAGCANHWMPQEVNMSRDIAL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 131 WKSKDGLSEDERRIVMRNLGFFSTADSLVANNLVLAVYRLITNPECRQYILRQAFEEAIHTHAYQYCIESLGMDEGEIFN 210
Cdd:PRK07209   85 WKSPNGLTEDERRIVKRNLGFFSTADSLVANNIVLAIYRHITNPECRQYLLRQAFEEAIHTHAYQYIVESLGLDEGEIFN 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 211 MYHEIPSVAKKASWGLKYTRSISDPMFQTGTPETDRQFLRNLIAYYCVLEGIFFYCGFTQILSMGRRNKMTGTAEQFQYI 290
Cdd:PRK07209  165 MYHEVPSIRAKDEFLIPFTRSLTDPNFKTGTPENDQKLLRNLIAFYCIMEGIFFYVGFTQILSLGRQNKMTGIAEQYQYI 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 291 LRDESMHLNFGIDVINQIKIENPHLWDAQMKDEATQMILQGTQLEIEYARDTMPRGVLGMNAAMMEDYLKFIANRRLTQI 370
Cdd:PRK07209  245 LRDESMHLNFGIDLINQIKLENPHLWTAEFQAEIRELIKEAVELEYRYARDTMPRGVLGLNASMFKDYLRFIANRRLQQI 324

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1353832897 371 GLKEEYPGTTNPFPWMSEIMDLKKEKNFFETRVIEYQTGGALSWD 415
Cdd:PRK07209  325 GLKPQYPGTENPFPWMSEMIDLKKEKNFFETRVIEYQTGGALSWD 369
 
Name Accession Description Interval E-value
PRK07209 PRK07209
ribonucleotide-diphosphate reductase subunit beta; Validated
 51-415 0e+00

ribonucleotide-diphosphate reductase subunit beta; Validated


Pssm-ID: 235968  Cd Length: 369  Bit Score: 773.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897  51 SDAVARAKKALNDLDIQEGLDDLEGSAARVQVGDKQMINARADLNQLVPFKYDWAWQKYLDGCANHWMPQEVNMNADIAL 130
Cdd:PRK07209    5 DDEVKAVMPALDALAVATGLEELEGGAARVNVDDKRIINCRADVNQLVPFKYKWAWEKYLAGCANHWMPQEVNMSRDIAL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 131 WKSKDGLSEDERRIVMRNLGFFSTADSLVANNLVLAVYRLITNPECRQYILRQAFEEAIHTHAYQYCIESLGMDEGEIFN 210
Cdd:PRK07209   85 WKSPNGLTEDERRIVKRNLGFFSTADSLVANNIVLAIYRHITNPECRQYLLRQAFEEAIHTHAYQYIVESLGLDEGEIFN 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 211 MYHEIPSVAKKASWGLKYTRSISDPMFQTGTPETDRQFLRNLIAYYCVLEGIFFYCGFTQILSMGRRNKMTGTAEQFQYI 290
Cdd:PRK07209  165 MYHEVPSIRAKDEFLIPFTRSLTDPNFKTGTPENDQKLLRNLIAFYCIMEGIFFYVGFTQILSLGRQNKMTGIAEQYQYI 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 291 LRDESMHLNFGIDVINQIKIENPHLWDAQMKDEATQMILQGTQLEIEYARDTMPRGVLGMNAAMMEDYLKFIANRRLTQI 370
Cdd:PRK07209  245 LRDESMHLNFGIDLINQIKLENPHLWTAEFQAEIRELIKEAVELEYRYARDTMPRGVLGLNASMFKDYLRFIANRRLQQI 324

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1353832897 371 GLKEEYPGTTNPFPWMSEIMDLKKEKNFFETRVIEYQTGGALSWD 415
Cdd:PRK07209  325 GLKPQYPGTENPFPWMSEMIDLKKEKNFFETRVIEYQTGGALSWD 369
NrdB COG0208
Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and ...
 84-414 7.24e-168

Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and metabolism]; Ribonucleotide reductase beta subunit, ferritin-like domain is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 439978 [Multi-domain]  Cd Length: 326  Bit Score: 473.12  E-value: 7.24e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897  84 DKQMINA-RADLNQLVPFKYDWAWQKYLDGCANHWMPQEVNMNADIALWKskdGLSEDERRIVMRNLGFFSTADSLVANN 162
Cdd:COG0208     2 DEPIINGlTTNRINWNPIKYPWAYELYKKQLANFWLPEEVPLSNDIKDWK---KLSDDERHLIKRVLGFLTLLDSIQGNN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 163 LVLAVYRLITNPECRQYILRQAFEEAIHTHAYQYCIESLGMDEGEIFNMYHEIPSVAKKASWGLKYTRSIsdpmfqtGTP 242
Cdd:COG0208    79 LVLALYPHVTAPEVRAVLSRQAFMEAIHAKSYSYILETLGLDIDEIFNWIEENPALQKKAEFILKYYDDL-------GTR 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 243 ETDRQFLRNLIAYYCvLEGIFFYCGFTQILSMGRRNKMTGTAEQFQYILRDESMHLNFGIDVINQIKIENPHLWDAQMKD 322
Cdd:COG0208   152 ETKKDLLKSLVASVF-LEGIFFYSGFAYPLSLARRGKMKGTAEIIRLILRDESLHGNFGIYLINTIREENPELFTEELKE 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 323 EATQMILQGTQLEIEYARDTMPRGVLGMNAAMMEDYLKFIANRRLTQIGLKEEYPGTTNPFPWMSEIMDLKKEKNFFETR 402
Cdd:COG0208   231 EIYELLKEAVELEKEYADDLFPDGILGLNAEDVKQYIRYIANKRLMNLGLEPLFEGDVNPFPWMSEGLDLNKKTDFFETR 310

                         330
                  ....*....|..
gi 1353832897 403 VIEYQTGGALSW 414
Cdd:COG0208   311 VTEYQKGGVEST 322
Ribonuc_red_sm pfam00268
Ribonucleotide reductase, small chain;
95-382 1.60e-118

Ribonucleotide reductase, small chain;


Pssm-ID: 425568 [Multi-domain]  Cd Length: 276  Bit Score: 346.02  E-value: 1.60e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897  95 NQLVPFKYDWAWQKYLDGCANHWMPQEVNMNADIALWKSkdgLSEDERRIVMRNLGFFSTADSLVANNLVLAVYRLITNP 174
Cdd:pfam00268   2 FNLNPIKYPEIWEFYKKLEANFWTPEEIPLSKDIKDWKK---LSEDEREFIKRVLAFLALLDTLVNENLVERFSREVQTP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 175 ECRQYILRQAFEEAIHTHAYQYCIESLGMDEGEI---FNMYHEIPSVAKKASWGLKYTRSisdpmfqtgtpeTDRQFLRN 251
Cdd:pfam00268  79 EARAFYGFQAFMENIHSESYSYILDTLGKDPEEIdelFNWIETNPALQKKAEWILKWYQD------------FDSDFLER 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 252 LIAYYCvLEGIFFYCGFTQILSMGRRNKMTGTAEQFQYILRDESMHLNFGIDVINQIKIENPHLWDAQMKDEATQMILQG 331
Cdd:pfam00268 147 LVAFAI-LEGIFFYSGFAAILWLKRRGKMPGLAEIIELISRDEGLHGDFACLLFQHLKEENPELETKELKEEVYDLIKEA 225

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1353832897 332 TQLEIEYARDTMPRGVLGMNAAMMEDYLKFIANRRLTQIGLKEEYPGTTNP 382
Cdd:pfam00268 226 VELEKEFLDDALPVGLLGMNAEDVKQYIEYVADRRLMNLGYEKLYNVEVNP 276
RNRR2 cd01049
Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide ...
 95-391 3.50e-113

Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide Reductase, R2/beta subunit (RNRR2) is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in all eukaryotes, many prokaryotes, several viruses, and few archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites. The beta subunit (R2) contains a diiron cluster that, in its reduced state, reacts with dioxygen to form a stable tyrosyl radical and a diiron(III) cluster. This essential tyrosyl radical is proposed to generate a thiyl radical, located on a cysteine residue in the R1 active site that initiates ribonucleotide reduction. The beta subunit is composed of 10-13 helices, the 8 longest helices form an alpha-helical bundle; some have 2 addition beta strands. Yeast is unique in that it assembles both homodimers and heterodimers of RNRR2. The yeast heterodimer, Y2Y4, contains R2 (Y2) and a R2 homolog (Y4) that lacks the diiron center and is proposed to only assist in cofactor assembly, and perhaps stabilize R1 (Y1) in its active conformation.


Pssm-ID: 153108 [Multi-domain]  Cd Length: 288  Bit Score: 333.05  E-value: 3.50e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897  95 NQLVPFKYDWAWQKYLDGCANHWMPQEVNMNADIALWKSkdgLSEDERRIVMRNLGFFSTADSLVANNLVLAVYRLITNP 174
Cdd:cd01049     1 FNLNPIKYPWAWELYKKAEANFWTPEEIDLSKDLKDWEK---LTEAERHFIKRVLAFLAALDSIVGENLVELFSRHVQIP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 175 ECRQYILRQAFEEAIHTHAYQYCIESLGMDE--GEIFNMYHEIPSVAKKASWGLKYTRSISDPmfqtgtpeTDRQFLRNL 252
Cdd:cd01049    78 EARAFYGFQAFMENIHSESYSYILDTLGKDEerDELFEAIETDPALKKKADWILRWYDNLDDN--------TKESFAERL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 253 IAYYCvLEGIFFYCGFTQILSMGRRNKMTGTAEQFQYILRDESMHLNFGIDVINQIKIENPHLWDAQMKDEATQMILQGT 332
Cdd:cd01049   150 VAFAI-LEGIFFYSGFAAIFWLARRGKMPGLAEIIELISRDESLHGDFACLLIRELLNENPELFTEEFKEEVYELIKEAV 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 333 QLEIEYARDTMPRGVLGMNAAMMEDYLKFIANRRLTQIGLKEEYPG-TTNPFPWMSEIMD 391
Cdd:cd01049   229 ELEKEFARDLLPDGILGLNKEDMKQYIEYVANRRLENLGLEKLFNVeDKNPFDWMELISD 288
 
Name Accession Description Interval E-value
PRK07209 PRK07209
ribonucleotide-diphosphate reductase subunit beta; Validated
 51-415 0e+00

ribonucleotide-diphosphate reductase subunit beta; Validated


Pssm-ID: 235968  Cd Length: 369  Bit Score: 773.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897  51 SDAVARAKKALNDLDIQEGLDDLEGSAARVQVGDKQMINARADLNQLVPFKYDWAWQKYLDGCANHWMPQEVNMNADIAL 130
Cdd:PRK07209    5 DDEVKAVMPALDALAVATGLEELEGGAARVNVDDKRIINCRADVNQLVPFKYKWAWEKYLAGCANHWMPQEVNMSRDIAL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 131 WKSKDGLSEDERRIVMRNLGFFSTADSLVANNLVLAVYRLITNPECRQYILRQAFEEAIHTHAYQYCIESLGMDEGEIFN 210
Cdd:PRK07209   85 WKSPNGLTEDERRIVKRNLGFFSTADSLVANNIVLAIYRHITNPECRQYLLRQAFEEAIHTHAYQYIVESLGLDEGEIFN 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 211 MYHEIPSVAKKASWGLKYTRSISDPMFQTGTPETDRQFLRNLIAYYCVLEGIFFYCGFTQILSMGRRNKMTGTAEQFQYI 290
Cdd:PRK07209  165 MYHEVPSIRAKDEFLIPFTRSLTDPNFKTGTPENDQKLLRNLIAFYCIMEGIFFYVGFTQILSLGRQNKMTGIAEQYQYI 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 291 LRDESMHLNFGIDVINQIKIENPHLWDAQMKDEATQMILQGTQLEIEYARDTMPRGVLGMNAAMMEDYLKFIANRRLTQI 370
Cdd:PRK07209  245 LRDESMHLNFGIDLINQIKLENPHLWTAEFQAEIRELIKEAVELEYRYARDTMPRGVLGLNASMFKDYLRFIANRRLQQI 324

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1353832897 371 GLKEEYPGTTNPFPWMSEIMDLKKEKNFFETRVIEYQTGGALSWD 415
Cdd:PRK07209  325 GLKPQYPGTENPFPWMSEMIDLKKEKNFFETRVIEYQTGGALSWD 369
NrdB COG0208
Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and ...
 84-414 7.24e-168

Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and metabolism]; Ribonucleotide reductase beta subunit, ferritin-like domain is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 439978 [Multi-domain]  Cd Length: 326  Bit Score: 473.12  E-value: 7.24e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897  84 DKQMINA-RADLNQLVPFKYDWAWQKYLDGCANHWMPQEVNMNADIALWKskdGLSEDERRIVMRNLGFFSTADSLVANN 162
Cdd:COG0208     2 DEPIINGlTTNRINWNPIKYPWAYELYKKQLANFWLPEEVPLSNDIKDWK---KLSDDERHLIKRVLGFLTLLDSIQGNN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 163 LVLAVYRLITNPECRQYILRQAFEEAIHTHAYQYCIESLGMDEGEIFNMYHEIPSVAKKASWGLKYTRSIsdpmfqtGTP 242
Cdd:COG0208    79 LVLALYPHVTAPEVRAVLSRQAFMEAIHAKSYSYILETLGLDIDEIFNWIEENPALQKKAEFILKYYDDL-------GTR 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 243 ETDRQFLRNLIAYYCvLEGIFFYCGFTQILSMGRRNKMTGTAEQFQYILRDESMHLNFGIDVINQIKIENPHLWDAQMKD 322
Cdd:COG0208   152 ETKKDLLKSLVASVF-LEGIFFYSGFAYPLSLARRGKMKGTAEIIRLILRDESLHGNFGIYLINTIREENPELFTEELKE 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 323 EATQMILQGTQLEIEYARDTMPRGVLGMNAAMMEDYLKFIANRRLTQIGLKEEYPGTTNPFPWMSEIMDLKKEKNFFETR 402
Cdd:COG0208   231 EIYELLKEAVELEKEYADDLFPDGILGLNAEDVKQYIRYIANKRLMNLGLEPLFEGDVNPFPWMSEGLDLNKKTDFFETR 310

                         330
                  ....*....|..
gi 1353832897 403 VIEYQTGGALSW 414
Cdd:COG0208   311 VTEYQKGGVEST 322
Ribonuc_red_sm pfam00268
Ribonucleotide reductase, small chain;
95-382 1.60e-118

Ribonucleotide reductase, small chain;


Pssm-ID: 425568 [Multi-domain]  Cd Length: 276  Bit Score: 346.02  E-value: 1.60e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897  95 NQLVPFKYDWAWQKYLDGCANHWMPQEVNMNADIALWKSkdgLSEDERRIVMRNLGFFSTADSLVANNLVLAVYRLITNP 174
Cdd:pfam00268   2 FNLNPIKYPEIWEFYKKLEANFWTPEEIPLSKDIKDWKK---LSEDEREFIKRVLAFLALLDTLVNENLVERFSREVQTP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 175 ECRQYILRQAFEEAIHTHAYQYCIESLGMDEGEI---FNMYHEIPSVAKKASWGLKYTRSisdpmfqtgtpeTDRQFLRN 251
Cdd:pfam00268  79 EARAFYGFQAFMENIHSESYSYILDTLGKDPEEIdelFNWIETNPALQKKAEWILKWYQD------------FDSDFLER 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 252 LIAYYCvLEGIFFYCGFTQILSMGRRNKMTGTAEQFQYILRDESMHLNFGIDVINQIKIENPHLWDAQMKDEATQMILQG 331
Cdd:pfam00268 147 LVAFAI-LEGIFFYSGFAAILWLKRRGKMPGLAEIIELISRDEGLHGDFACLLFQHLKEENPELETKELKEEVYDLIKEA 225

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1353832897 332 TQLEIEYARDTMPRGVLGMNAAMMEDYLKFIANRRLTQIGLKEEYPGTTNP 382
Cdd:pfam00268 226 VELEKEFLDDALPVGLLGMNAEDVKQYIEYVADRRLMNLGYEKLYNVEVNP 276
RNRR2 cd01049
Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide ...
 95-391 3.50e-113

Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide Reductase, R2/beta subunit (RNRR2) is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in all eukaryotes, many prokaryotes, several viruses, and few archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites. The beta subunit (R2) contains a diiron cluster that, in its reduced state, reacts with dioxygen to form a stable tyrosyl radical and a diiron(III) cluster. This essential tyrosyl radical is proposed to generate a thiyl radical, located on a cysteine residue in the R1 active site that initiates ribonucleotide reduction. The beta subunit is composed of 10-13 helices, the 8 longest helices form an alpha-helical bundle; some have 2 addition beta strands. Yeast is unique in that it assembles both homodimers and heterodimers of RNRR2. The yeast heterodimer, Y2Y4, contains R2 (Y2) and a R2 homolog (Y4) that lacks the diiron center and is proposed to only assist in cofactor assembly, and perhaps stabilize R1 (Y1) in its active conformation.


Pssm-ID: 153108 [Multi-domain]  Cd Length: 288  Bit Score: 333.05  E-value: 3.50e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897  95 NQLVPFKYDWAWQKYLDGCANHWMPQEVNMNADIALWKSkdgLSEDERRIVMRNLGFFSTADSLVANNLVLAVYRLITNP 174
Cdd:cd01049     1 FNLNPIKYPWAWELYKKAEANFWTPEEIDLSKDLKDWEK---LTEAERHFIKRVLAFLAALDSIVGENLVELFSRHVQIP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 175 ECRQYILRQAFEEAIHTHAYQYCIESLGMDE--GEIFNMYHEIPSVAKKASWGLKYTRSISDPmfqtgtpeTDRQFLRNL 252
Cdd:cd01049    78 EARAFYGFQAFMENIHSESYSYILDTLGKDEerDELFEAIETDPALKKKADWILRWYDNLDDN--------TKESFAERL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 253 IAYYCvLEGIFFYCGFTQILSMGRRNKMTGTAEQFQYILRDESMHLNFGIDVINQIKIENPHLWDAQMKDEATQMILQGT 332
Cdd:cd01049   150 VAFAI-LEGIFFYSGFAAIFWLARRGKMPGLAEIIELISRDESLHGDFACLLIRELLNENPELFTEEFKEEVYELIKEAV 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 333 QLEIEYARDTMPRGVLGMNAAMMEDYLKFIANRRLTQIGLKEEYPG-TTNPFPWMSEIMD 391
Cdd:cd01049   229 ELEKEFARDLLPDGILGLNKEDMKQYIEYVANRRLENLGLEKLFNVeDKNPFDWMELISD 288
nrdF PRK09614
ribonucleotide-diphosphate reductase subunit beta; Reviewed
 99-415 8.49e-75

ribonucleotide-diphosphate reductase subunit beta; Reviewed


Pssm-ID: 236591 [Multi-domain]  Cd Length: 324  Bit Score: 235.87  E-value: 8.49e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897  99 PFKYDWA---WQKYLdgcANHWMPQEVNMNADIALWKSkdgLSEDERRIVMRNLGFFSTADSLVANNLVLAVYRLITNPE 175
Cdd:PRK09614   16 KIEDPWDyeaWKRLT---ANFWLPEEVPLSNDLKDWKK---LSDEEKNLYTRVFGGLTLLDTLQNNNGMPNLMPDITTPE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 176 CRQYILRQAFEEAIHTHAYQYCIESLGM--DEGEIFNMYHEIPSVAKKAswglKYTRSISDPMfqtgtpetDRQFLRNLI 253
Cdd:PRK09614   90 EEAVLANIAFMEAVHAKSYSYIFSTLCSpeEIDEAFEWAEENPYLQKKA----DIIQDFYEPL--------KKKILRKAA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 254 AYYCVLEGIFFYCGFTQILSMGRRNKMTGTAEQFQYILRDESMHLNFGIDVINQIKIENPHLWDAQMKDEATQMILQGTQ 333
Cdd:PRK09614  158 VASVFLEGFLFYSGFYYPLYLARQGKMTGTAQIIRLIIRDESLHGYYIGYLFQEGLEELPELEQEELKDEIYDLLYELYE 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 334 LEIEYARDTMprGVLGmNAAMMEDYLKFIANRRLTQIGLKEEYPG-TTNPFPWMSEIMDLKKEK-NFFETRVIEYQTGGA 411
Cdd:PRK09614  238 NEEAYTELLY--DIVG-LAEDVKKYIRYNANKRLMNLGLEPLFPEeEEVNPIWLNGLSNNADENhDFFEGKGTSYVKGAT 314


                  ....*
gi 1353832897 412 L-SWD 415
Cdd:PRK09614  315 EaTED 319
PTZ00211 PTZ00211
ribonucleoside-diphosphate reductase small subunit; Provisional
 87-413 3.07e-53

ribonucleoside-diphosphate reductase small subunit; Provisional


Pssm-ID: 240315 [Multi-domain]  Cd Length: 330  Bit Score: 180.35  E-value: 3.07e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897  87 MINARADLNQLVPFKYDWAWQKYLDGCANHWMPQEVNMNADIALWKSkdgLSEDERRIVMRNLGFFSTADSLVANNLVLA 166
Cdd:PTZ00211   14 LLKENPDRFVLFPIKYPDIWRMYKKAEASFWTAEEIDLGNDLKDWEK---LNDGERHFIKHVLAFFAASDGIVLENLAQR 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 167 VYRLITNPECRQYILRQAFEEAIHTHAYQYCIESLGMDEGE---IFNMYHEIPSVAKKASWGLKYTRSisdpmfqtgtpe 243
Cdd:PTZ00211   91 FMREVQVPEARCFYGFQIAMENIHSETYSLLIDTYITDEEEkdrLFHAIETIPAIKKKAEWAAKWINS------------ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 244 tDRQFLRNLIAYYCVlEGIFFYCGFTQILSMGRRNKMTGTAEQFQYILRDESMHLNFGIDVINQIKIENPhlwdaqmKDE 323
Cdd:PTZ00211  159 -SNSFAERLVAFAAV-EGIFFSGSFCAIFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLYSHLKNKLP-------RER 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 324 ATQMILQGTQLEIEYARDTMPRGVLGMNAAMMEDYLKFIANRRLTQIGLKEEYpGTTNPFPWMsEIMDLKKEKNFFETRV 403
Cdd:PTZ00211  230 VQEIIKEAVEIEREFICDALPVDLIGMNSRLMAQYIEFVADRLLVALGVPKIY-NSKNPFDWM-DMISLQGKTNFFEKRV 307

                         330
                  ....*....|
gi 1353832897 404 IEYQTGGALS 413
Cdd:PTZ00211  308 GEYQKAGVMA 317
PLN02492 PLN02492
ribonucleoside-diphosphate reductase
 97-413 7.41e-52

ribonucleoside-diphosphate reductase


Pssm-ID: 215272  Cd Length: 324  Bit Score: 176.39  E-value: 7.41e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897  97 LVPFKYDWAWQKYLDGCANHWMPQEVNMNADIALWkskDGLSEDERRIVMRNLGFFSTADSLVANNLVLAVYRLITNPEC 176
Cdd:PLN02492   13 MFPIKYPQIWEMYKKAEASFWTAEEVDLSADLKDW---EKLTDDERHFISHVLAFFAASDGIVLENLAARFMKEVQVPEA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 177 RQYILRQAFEEAIHTHAYQYCIESLGMDEGE---IFNMYHEIPSVAKKASWGLKYTRSisdpmfqtgtpetDRQFLRNLI 253
Cdd:PLN02492   90 RAFYGFQIAIENIHSEMYSLLLDTYIKDPKEkdrLFNAIETIPCVAKKADWALRWIDS-------------SASFAERLV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 254 AYYCVlEGIFFYCGFTQILSMGRRNKMTGTAEQFQYILRDESMHLNFGIDVINqiKIENPHLWDaqmkdEATQMILQGTQ 333
Cdd:PLN02492  157 AFACV-EGIFFSGSFCAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLLYS--LLKNKLSEE-----RVKEIVCEAVE 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 334 LEIEYARDTMPRGVLGMNAAMMEDYLKFIANRRLTQIGLKEEYpGTTNPFPWMsEIMDLKKEKNFFETRVIEYQTGGALS 413
Cdd:PLN02492  229 IEKEFVCDALPCALVGMNADLMSQYIEFVADRLLVALGYEKVY-NVVNPFDWM-ELISLQGKTNFFEKRVGEYQKAGVMS 306
PRK12759 PRK12759
bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional
 99-415 5.40e-34

bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional


Pssm-ID: 139206 [Multi-domain]  Cd Length: 410  Bit Score: 130.92  E-value: 5.40e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897  99 PFKYDWAWQKYLDGCANHWMPQEVNMNADIALWKSKDgLSEDERRIVMRNLGFFSTADSLVANNLVLAVYRLITNPECRQ 178
Cdd:PRK12759  102 PFNYPWAVDLTVKHEKAHWIEDEIDLSEDVTDWKNGK-ITKVEKEYITNILRLFTQSDVAVGQNYYDQFIPLFKNNEIRN 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 179 YILRQAFEEAIHTHAYQYCIESLGMDEGEifnmYHEIpsvakkaswgLKYTRSISDPMFQTGTPETDRQFLRNLIAYYCV 258
Cdd:PRK12759  181 MLGSFAAREGIHQRAYALLNDTLGLPDSE----YHAF----------LEYKAMTDKIDFMMDADPTTRRGLGLCLAKTVF 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 259 LEGIFFYCGFTQILSMGRRNKMTGTAEQFQYILRDESMHLNFGIDVINQIKIENPHLWDAQMKDEATQMILQGTQLEIEY 338
Cdd:PRK12759  247 NEGVALFASFAMLLNFQRFGKMKGMGKVVEWSIRDESMHVEGNAALFRIYCQENPYIVDNEFKKEIYLMASKAVELEDRF 326

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1353832897 339 ARDTMPRGVL-GMNAAMMEDYLKFIANRRLTQIGLKEEYPGTTNPFPWMSEIMDLKKEKNFFETRVIEYQTGGAL-SWD 415
Cdd:PRK12759  327 IELAYELGTIeGLKADEVKQYIRHITDRRLNQLGLKEIYNIEKNPLTWLEWILNGADHTNFFENRVTEYEVAGLTgSWD 405
nrdB PRK09101
ribonucleotide-diphosphate reductase subunit beta; Reviewed
 117-386 4.68e-21

ribonucleotide-diphosphate reductase subunit beta; Reviewed


Pssm-ID: 181647  Cd Length: 376  Bit Score: 93.87  E-value: 4.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 117 WMPQEVNMNADIALWKSkdgLSEDERRIVMRNLGFFSTADSLVANNLVLAVYRLITNPECRQYILRQAFEEAIHTHAYQY 196
Cdd:PRK09101   49 WRPEEVDVSRDRIDYQA---LPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLVSIPELETWIETWSFSETIHSRSYTH 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 197 CIESLGMDEGEIFNMYHEIPSVAKKASwglkytrSIS---DPMFQT---------GTPETDRQ----FLRNLIA--YYC- 257
Cdd:PRK09101  126 IIRNIVNDPSVVFDDIVTNEEILKRAK-------DISsyyDDLIEMtsyyhllgeGTHTVNGKtvtvSLRELKKklYLCl 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 258 ----VLEGIFFYCGFTQILSMGRRNKMTGTAEQFQYILRDESMHLNFGIDVIN--QIKIENPHLWD--AQMKDEATQMIL 329
Cdd:PRK09101  199 msvnALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNlmRSGKDDPEMAEiaEECKQECYDLFV 278

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1353832897 330 QGTQLEIEYARDTMPRG-VLGMNAAMMEDYLKFIANRRLTQIGLKEEYPGTTNPFPWM 386
Cdd:PRK09101  279 QAAEQEKEWADYLFKDGsMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRSNPIPWI 336
PRK08326 PRK08326
R2-like ligand-binding oxidase;
91-371 5.96e-16

R2-like ligand-binding oxidase;


Pssm-ID: 236242  Cd Length: 311  Bit Score: 78.12  E-value: 5.96e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897  91 RADLNQLVPFKYDWA------WQKyldGCANHWMPQEVNMNADIALWKSkdgLSEDERRIVMRNLGFFSTADSLVANNL- 163
Cdd:PRK08326   10 HTDFKSLRSGGLNWNsfpmklFAK---GNAKFWNPADIDFSRDAEDWEK---LSDEERDYATRLCAQFIAGEEAVTLDIq 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 164 -----VLAVYRLitnpECRQYILRQAFEEAIHTHAYQYCIESLGMDEG------------EIFnmYHEIPSvakkASWGL 226
Cdd:PRK08326   84 plisaMAAEGRL----EDEMYLTQFAFEEAKHTEAFRRWFDAVGVTEDlsvytddnpsyrQIF--YEELPA----ALNRL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 227 KytrsiSDPmfqtgTPETdrqFLRNLIAYYCVLEGIFF---YCGFTQILsmGRRNKMTGTAEQFQYILRDESMHLNFGID 303
Cdd:PRK08326  154 S-----TDP-----SPEN---QVRASVTYNHVVEGVLAetgYYAWRKIC--VTRGILPGLQELVRRIGDDERRHIAWGTY 218

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 304 VINQIKIENPHLWDAQMK--DEATQMILQGTQLEIEYARDTMPrgvLGMNAAMMEDYLKFIANRRLTQIG 371
Cdd:PRK08326  219 TCRRLVAADDSNWDVFEErmNELLPLALGLIDEIFALYGDQIP---FELSNDEFVDYAADRGQRRLGAIE 285
nrdF2 PRK13966
ribonucleotide-diphosphate reductase subunit beta; Provisional
 114-415 3.11e-14

ribonucleotide-diphosphate reductase subunit beta; Provisional


Pssm-ID: 140022  Cd Length: 324  Bit Score: 73.22  E-value: 3.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 114 ANHWMPQEVNMNADIALWKSkdgLSEDERRIVMRNLGFFSTADSLVANNLVLAVYRLITNPECRQYILRQAFEEAIHTHA 193
Cdd:PRK13966   33 GNFWLPEKVPVSNDIPSWGT---LTAGEKQLTMRVFTGLTMLDTIQGTVGAVSLIPDALTPHEEAVLTNIAFMESVHAKS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 194 YQYCIESL--GMDEGEIFNMYHEIPSVAKKASWGLKYTRsisdpmfqtGTPETDRQFLRNLiayycvLEGIFFYCGFTQI 271
Cdd:PRK13966  110 YSQIFSTLcsTAEIDDAFRWSEENRNLQRKAEIVLQYYR---------GDEPLKRKVASTL------LESFLFYSGFYLP 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 272 LSMGRRNKMTGTAEQFQYILRDESMHLNF-------GIDVINQIKIEnphlwdaQMKDEATQMILQGTQLEIEYARDtmp 344
Cdd:PRK13966  175 MYWSSRAKLTNTADMIRLIIRDEAVHGYYigykfqrGLALVDDVTRA-------ELKDYTYELLFELYDNEVEYTQD--- 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 345 rgvLGMNAAMMED---YLKFIANRRLTQIGLKEEYP---GTTNPFPWMSEIMDLKKEKNFFETRVIEYQTGGALS----- 413
Cdd:PRK13966  245 ---LYDEVGLTEDvkkFLRYNANKALMNLGYEALFPrdeTDVNPAILSALSPNADENHDFFSGSGSSYVIGKAVVteddd 321


                  ..
gi 1353832897 414 WD 415
Cdd:PRK13966  322 WD 323
PRK13965 PRK13965
ribonucleotide-diphosphate reductase subunit beta; Provisional
 106-377 1.28e-11

ribonucleotide-diphosphate reductase subunit beta; Provisional


Pssm-ID: 184425 [Multi-domain]  Cd Length: 335  Bit Score: 65.18  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 106 WQKYldgCANHWMPQEVNMNADIALWKSkdgLSEDERRIVMRNLGFFSTADSLVANnlVLAVYRLitnPECR----QYIL 181
Cdd:PRK13965   39 WNRV---TQNFWLPEKVPVSNDLNSWRS---LGEDWQQLITRTFTGLTLLDTVQAT--VGDVAQI---PHSQtdheQVIY 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 182 RQ-AFEEAIHTHAYqycieslgmdeGEIFNMYHEIPSVAKKASWglkytrSISDPMFQtgtpetdrQFLRNLIAYY---- 256
Cdd:PRK13965  108 TNfAFMVAIHARSY-----------GTIFSTLCSSEQIEEAHEW------VVSTESLQ--------RRARVLIPYYtgdd 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 257 --------CVLEGIFFYCGFTQILSMGRRNKMTGTAEQFQYILRDESMHlNFGIDVINQIKIENPHLW-DAQMKDEATQM 327
Cdd:PRK13965  163 plkskvaaAMMPGFLLYGGFYLPFYLSARGKLPNTSDIIRLILRDKVIH-NYYSGYKYQQKVARLSPEkQAEMKAFVFDL 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1353832897 328 ILQGTQLEIEYARDtmprgvLGMNAAMMEDYLKFI---ANRRLTQIGLKEEYP 377
Cdd:PRK13965  242 LYELIDLEKAYLRE------LYAGFDLAEDAIRFSlynAGKFLQNLGYESPFT 288
nrdF1 PRK13967
ribonucleotide-diphosphate reductase subunit beta; Provisional
 95-376 4.69e-11

ribonucleotide-diphosphate reductase subunit beta; Provisional


Pssm-ID: 140023  Cd Length: 322  Bit Score: 63.59  E-value: 4.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897  95 NQLVPFKYDWAWQKYldgCANHWMPQEVNMNADIALWKSkdgLSEDERRIVMRNLGFFSTADSLVANNLVLAVYRLITNP 174
Cdd:PRK13967   15 NRLLDAKDLQVWERL---TGNFWLPEKIPLSNDLASWQT---LSSTEQQTTIRVFTGLTLLDTAQATVGAVAMIDDAVTP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 175 ECRQYILRQAFEEAIHTHAYQYCIESLGMDE--GEIFNMYHEIPSVAKKASWGLKYTRsisdpmfqtGTPETDRQflrnl 252
Cdd:PRK13967   89 HEEAVLTNMAFMESVHAKSYSSIFSTLCSTKqiDDAFDWSEQNPYLQRKAQIIVDYYR---------GDDALKRK----- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 253 iAYYCVLEGIFFYCGFTQILSMGRRNKMTGTAEQFQYILRDESMHlnfGIDVINQIKIENPHLWDAQMKD--EATQMILQ 330
Cdd:PRK13967  155 -ASSVMLESFLFYSGFYLPMYWSSRGKLTNTADLIRLIIRDEAVH---GYYIGYKCQRGLADLTDAERADhrEYTCELLH 230

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1353832897 331 GTQL-EIEYARDTMPRgvLGMNAAMMEdYLKFIANRRLTQIGLKEEY 376
Cdd:PRK13967  231 TLYAnEIDYAHDLYDE--LGWTDDVLP-YMRYNANKALANLGYQPAF 274
RNRR2_Rv0233_like cd07911
Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Rv0233 is a Mycobacterium ...
 117-372 7.02e-10

Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Rv0233 is a Mycobacterium tuberculosis ribonucleotide reductase R2 protein with a heterodinuclear manganese/iron-carboxylate cofactor located in its metal center. The Rv0233-like family may represent a structural/functional counterpart of the evolutionary ancestor of the RNRR2's (Ribonucleotide Reductase, R2/beta subunit) and the bacterial multicomponent monooxygenases. RNRR2s belong to a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in prokaryotes and archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites.


Pssm-ID: 153120  Cd Length: 280  Bit Score: 59.66  E-value: 7.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 117 WMPQEVNMNADIALWkskDGLSEDERRIVMRNLGFFSTADSLVANNL--VLAVYRLITNPECRQYILRQAFEEAIHTHAY 194
Cdd:cd07911    22 WNPADIDFSQDREDW---EQLSEEERDLALRLCAGFIAGEEAVTLDLlpLMMAMAAEGRLEEEMYLTQFLFEEAKHTDFF 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 195 QYCIESLGMDEG----------EIFnmYHEIPSvakkASWGLKYTRSisdpmfqtgtpetDRQFLRNLIAYYCVLEGIFF 264
Cdd:cd07911    99 RRWLDAVGVSDDlsdlhtavyrEPF--YEALPY----AELRLYLDAS-------------PAAQVRASVTYNMIVEGVLA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1353832897 265 ---YCGFTQILSmgRRNKMTGTAEQFQYILRDESMHLNFGIDVINQIKIENPHLWDA---QMkDEATQMILQgtqlEIEY 338
Cdd:cd07911   160 etgYYAWRTICE--KRGILPGMQEGIRRLGDDESRHIAWGTFTCRRLVAADDANWDVfeeRM-NELVPHALG----LIDE 232

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1353832897 339 ARDTMPRGVLGMNAAMMEDYLKFIANRRLTQIGL 372
Cdd:cd07911   233 IFELYDEMPFGLDPDELMQYAVDQFQRRLGYIER 266
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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