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Conserved domains on  [gi|1352182897|gb|AVI53913|]
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AsnC family transcriptional regulator [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

transcriptional regulator AsnC( domain architecture ID 11485253)

transcriptional regulator AsnC acts as an autogenously regulated activator of asparagine synthetase A transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-152 4.83e-117

DNA-binding transcriptional regulator AsnC; Provisional


:

Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 326.67  E-value: 4.83e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352182897   1 MENYLIDNLDRGILEALMGNARTAYAELAKQFGVSPGTIHVRVEKMKQAGIITGARIDVSPKQLGYDVGCFIGIILKSAK 80
Cdd:PRK11179    2 MENYQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSAK 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1352182897  81 DYPSALAKLESLDEVTEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLIVLQNPIMRTIKP 152
Cdd:PRK11179   82 DYPSALAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLISLQNPIMRTIKP 153
 
Name Accession Description Interval E-value
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-152 4.83e-117

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 326.67  E-value: 4.83e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352182897   1 MENYLIDNLDRGILEALMGNARTAYAELAKQFGVSPGTIHVRVEKMKQAGIITGARIDVSPKQLGYDVGCFIGIILKSAK 80
Cdd:PRK11179    2 MENYQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSAK 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1352182897  81 DYPSALAKLESLDEVTEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLIVLQNPIMRTIKP 152
Cdd:PRK11179   82 DYPSALAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLISLQNPIMRTIKP 153
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
6-142 2.05e-47

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 149.93  E-value: 2.05e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352182897   6 IDNLDRGILEALMGNARTAYAELAKQFGVSPGTIHVRVEKMKQAGIITGARIDVSPKQLGYDVGCFIGIILKSaKDYPSA 85
Cdd:COG1522     3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPP-HRLDEF 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1352182897  86 LAKLESLDEVTEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLIVL 142
Cdd:COG1522    82 AEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 6-113 7.53e-41

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 132.25  E-value: 7.53e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352182897    6 IDNLDRGILEALMGNARTAYAELAKQFGVSPGTIHVRVEKMKQAGIITGARIDVSPKQLGYDVGCFIGIILKSAKDYPSA 85
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKLEEF 80

                           90       100
                   ....*....|....*....|....*...
gi 1352182897   86 LAKLESLDEVTEAYYTTGHYSIFIKVMC 113
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 72-143 6.34e-18

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 72.94  E-value: 6.34e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1352182897  72 IGIILKSAKDYPSALAKLESLDEVTEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLIVLQ 143
Cdd:pfam01037   1 VEVKLEPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLS 72
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 5-56 5.30e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 44.60  E-value: 5.30e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1352182897   5 LIDNLDRGILEALMGNARTAyAELAKQFGVSPGTIHVRVEKMKQAGIITGAR 56
Cdd:cd00090     4 LSDPTRLRILRLLLEGPLTV-SELAERLGLSQSTVSRHLKKLEEAGLVESRR 54
 
Name Accession Description Interval E-value
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-152 4.83e-117

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 326.67  E-value: 4.83e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352182897   1 MENYLIDNLDRGILEALMGNARTAYAELAKQFGVSPGTIHVRVEKMKQAGIITGARIDVSPKQLGYDVGCFIGIILKSAK 80
Cdd:PRK11179    2 MENYQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSAK 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1352182897  81 DYPSALAKLESLDEVTEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLIVLQNPIMRTIKP 152
Cdd:PRK11179   82 DYPSALAKLESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLISLQNPIMRTIKP 153
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
6-142 2.05e-47

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 149.93  E-value: 2.05e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352182897   6 IDNLDRGILEALMGNARTAYAELAKQFGVSPGTIHVRVEKMKQAGIITGARIDVSPKQLGYDVGCFIGIILKSaKDYPSA 85
Cdd:COG1522     3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPP-HRLDEF 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1352182897  86 LAKLESLDEVTEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLIVL 142
Cdd:COG1522    82 AEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 6-113 7.53e-41

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 132.25  E-value: 7.53e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352182897    6 IDNLDRGILEALMGNARTAYAELAKQFGVSPGTIHVRVEKMKQAGIITGARIDVSPKQLGYDVGCFIGIILKSAKDYPSA 85
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKLEEF 80

                           90       100
                   ....*....|....*....|....*...
gi 1352182897   86 LAKLESLDEVTEAYYTTGHYSIFIKVMC 113
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 72-143 6.34e-18

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 72.94  E-value: 6.34e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1352182897  72 IGIILKSAKDYPSALAKLESLDEVTEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLIVLQ 143
Cdd:pfam01037   1 VEVKLEPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLS 72
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
7-47 6.85e-13

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 58.92  E-value: 6.85e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1352182897   7 DNLDRGILEALMGNARTAYAELAKQFGVSPGTIHVRVEKMK 47
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
9-52 2.18e-10

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 52.82  E-value: 2.18e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1352182897   9 LDRGILEALMGNARTAYAELAKQFGVSPGTIHVRVEKMKQAGII 52
Cdd:pfam13412   2 TDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
6-143 2.23e-09

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 52.84  E-value: 2.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352182897   6 IDNLDRGILEALMGNARTAYAELAKQFGVSPGTIHVRVEKMKQAGIITGARIDVSPKQLGYDVGCFIGIILksAKDYPSA 85
Cdd:PRK11169   12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITL--NRGAPDV 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1352182897  86 LAK----LESLDEVTEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLIVLQ 143
Cdd:PRK11169   90 FEQfnaaVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVME 151
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 5-56 5.30e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 44.60  E-value: 5.30e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1352182897   5 LIDNLDRGILEALMGNARTAyAELAKQFGVSPGTIHVRVEKMKQAGIITGAR 56
Cdd:cd00090     4 LSDPTRLRILRLLLEGPLTV-SELAERLGLSQSTVSRHLKKLEEAGLVESRR 54
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 11-56 2.12e-06

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 42.53  E-value: 2.12e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1352182897  11 RGILEALMGNARTAYAELAKQFGVSPGTIHVRVEKMKQAGIITGAR 56
Cdd:pfam12840  13 LRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVR 58
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
11-56 5.28e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 40.40  E-value: 5.28e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1352182897  11 RGILEALMGNARTAYaELAKQFGVSPGTIHVRVEKMKQAGIITGAR 56
Cdd:COG1777    20 RRILALLSEEPAYVS-ELARELGVSRQAVYKHLRKLEEAGLVESYR 64
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
10-53 2.01e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 39.48  E-value: 2.01e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1352182897  10 DRGILEALMGNARTAYAELAKQFGVSPGTIHVRVEKMKQAGIIT 53
Cdd:COG3398    99 PRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVE 142
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
11-56 3.95e-04

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 37.56  E-value: 3.95e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1352182897  11 RGILEALMGNARTAyAELAKQFGVSPGTI--HVRVekMKQAGIITGAR 56
Cdd:COG0640    23 LRILRLLAEGELCV-GELAEALGLSQSTVshHLKV--LREAGLVTSRR 67
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
13-53 2.20e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.88  E-value: 2.20e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1352182897   13 ILEALMGNARTAyAELAKQFGVSPGTIHVRVEKMKQAGIIT 53
Cdd:smart00418   2 ILKLLAEGELCV-CELAEILGLSQSTVSHHLKKLREAGLVE 41
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
13-53 7.44e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 34.17  E-value: 7.44e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1352182897  13 ILEALMGNARTAyAELAKQFGVSPGTIHVRVEKMKQAGIIT 53
Cdd:COG4189    24 ILRLLAEEPLNV-NELAEALGLPKSTVSYHIRKLEEAGLIR 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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