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Conserved domains on  [gi|1039020415|gb|ANM69490|]
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tRNA/rRNA methyltransferase (SpoU) family protein [Arabidopsis thaliana]

Protein Classification

TrmH family RNA methyltransferase( domain architecture ID 13031027)

TrmH family RNA methyltransferase catalyzes the methylation of rRNA or tRNA at specific sites in a S-adenosyl-L-methionine (SAM)-dependent manner

CATH:  3.40.1280.10
EC:  2.1.1.-
Gene Ontology:  GO:0008173|GO:1904047|GO:0003723|GO:0032259|GO:0008168|GO:0030488
PubMed:  11763972|17338813|30457841|18029778
SCOP:  3001122

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 139-260 1.16e-51

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


:

Pssm-ID: 349965  Cd Length: 162  Bit Score: 165.72  E-value: 1.16e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039020415 139 ERTDRFRRVVENRSYSVCLVVEGLSDFGNISAAFRSADALGIQSVHVVSCDSSKRYNgnRHVSMGAEKWLDIEFWDTPKE 218
Cdd:cd18092     1 ERLERIEEVLARRTRDLTVVLENVHDPHNASAVLRTCDAFGVQDVHVIEPKNKFKKN--RGVAMGADKWLDVHRHDSTEE 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1039020415 219 CFKVLKSRGYRIATTHLGMDTVSIYDMDWSCPTAIVVGNEGR 260
Cdd:cd18092    79 CLAALKEQGYRIVATSLSPDAVPLDELDYTRPTALVFGNEKD 120
 
Name Accession Description Interval E-value
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 139-260 1.16e-51

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349965  Cd Length: 162  Bit Score: 165.72  E-value: 1.16e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039020415 139 ERTDRFRRVVENRSYSVCLVVEGLSDFGNISAAFRSADALGIQSVHVVSCDSSKRYNgnRHVSMGAEKWLDIEFWDTPKE 218
Cdd:cd18092     1 ERLERIEEVLARRTRDLTVVLENVHDPHNASAVLRTCDAFGVQDVHVIEPKNKFKKN--RGVAMGADKWLDVHRHDSTEE 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1039020415 219 CFKVLKSRGYRIATTHLGMDTVSIYDMDWSCPTAIVVGNEGR 260
Cdd:cd18092    79 CLAALKEQGYRIVATSLSPDAVPLDELDYTRPTALVFGNEKD 120
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 154-260 4.56e-27

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 101.84  E-value: 4.56e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039020415 154 SVCLVVEGLSDFGNISAAFRSADALGIQSVHVVSCDSSKRYNGN-RHVSMGAEKWLDIEFWDTPKECFKVLKSRGYRIAT 232
Cdd:pfam00588   1 PLVVVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRSADPYNPKaIRASAGALFHLPLVVVDNLEEALKDLKEAGYAVVA 80

                          90       100
                  ....*....|....*....|....*...
gi 1039020415 233 THLGmdTVSIYDMDWSCPTAIVVGNEGR 260
Cdd:pfam00588  81 TSLG--GKSLYEIDFPKKVALVFGNEGT 106
PRK11081 PRK11081
tRNA guanosine-2'-O-methyltransferase; Provisional
 136-258 5.52e-19

tRNA guanosine-2'-O-methyltransferase; Provisional


Pssm-ID: 236837 [Multi-domain]  Cd Length: 229  Bit Score: 82.73  E-value: 5.52e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039020415 136 MMEERTDRFRRVVENR--SYSVCLvvEGLSDFGNISAAFRSADALGIQSVHVVSCDSSKRYNGNrhVSMGAEKWLDIEFW 213
Cdd:PRK11081    1 MNPERYARICEMLARRqpDLTVCM--EQVHKPHNVSAIIRTADAVGVHEVHAVWPGSRMRTMGS--TAAGSNSWVQVKTH 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1039020415 214 DTPKECFKVLKSRGYRIATTHLGMDTVSIYDMDWSCPTAIVVGNE 258
Cdd:PRK11081   77 RTIGDAVAHLKGQGMQILATHLSDTAVDFREIDYTRPTCILMGQE 121
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 157-260 5.46e-15

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 72.54  E-value: 5.46e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039020415 157 LVVEGLSDFGNISAAFRSADALGIQSVhVVSCDSSKRYNGN--RhVSMGAEKWLDIEFWDTPKECFKVLKSRGYRIATTH 234
Cdd:COG0566   118 LVLDGVQDPGNLGAILRSAAAFGVDGV-ILPKRRADPYNPKvvR-ASAGALFHVPVARVTNLADALEELKEAGFWVVGTD 195

                          90       100
                  ....*....|....*....|....*.
gi 1039020415 235 LGmDTVSIYDMDWSCPTAIVVGNEGR 260
Cdd:COG0566   196 LD-GEASLYEVDLPGPVALVLGNEGK 220
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 119-260 3.83e-10

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 58.51  E-value: 3.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039020415 119 GEVHlssREVLEAVSPHMMEERTDrFRRVVENRSYSVCLVVEGLSDFGNISAAFRSADALGIQSVhVVSCDSSKRYN-GN 197
Cdd:TIGR00186  59 GGNH---QGIAAKVKPILYKDLND-LYKTAKSKKQPFLLILDEITDPHNLGAILRTAEAFGVDGV-ILPKRRSAPLNsTV 133

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039020415 198 RHVSMGAEKWLDIEFWDTPKECFKVLKSRGYRI-ATTHLGMDTvsIYDMDWSCPTAIVVGNEGR 260
Cdd:TIGR00186 134 VKTSSGAVEYVPLARVTNLSRTITKLKESGFWTvGTDLDAQDT--LYQVKLTKPLALVVGNEGE 195
 
Name Accession Description Interval E-value
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 139-260 1.16e-51

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349965  Cd Length: 162  Bit Score: 165.72  E-value: 1.16e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039020415 139 ERTDRFRRVVENRSYSVCLVVEGLSDFGNISAAFRSADALGIQSVHVVSCDSSKRYNgnRHVSMGAEKWLDIEFWDTPKE 218
Cdd:cd18092     1 ERLERIEEVLARRTRDLTVVLENVHDPHNASAVLRTCDAFGVQDVHVIEPKNKFKKN--RGVAMGADKWLDVHRHDSTEE 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1039020415 219 CFKVLKSRGYRIATTHLGMDTVSIYDMDWSCPTAIVVGNEGR 260
Cdd:cd18092    79 CLAALKEQGYRIVATSLSPDAVPLDELDYTRPTALVFGNEKD 120
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 154-260 4.56e-27

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 101.84  E-value: 4.56e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039020415 154 SVCLVVEGLSDFGNISAAFRSADALGIQSVHVVSCDSSKRYNGN-RHVSMGAEKWLDIEFWDTPKECFKVLKSRGYRIAT 232
Cdd:pfam00588   1 PLVVVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRSADPYNPKaIRASAGALFHLPLVVVDNLEEALKDLKEAGYAVVA 80

                          90       100
                  ....*....|....*....|....*...
gi 1039020415 233 THLGmdTVSIYDMDWSCPTAIVVGNEGR 260
Cdd:pfam00588  81 TSLG--GKSLYEIDFPKKVALVFGNEGT 106
PRK11081 PRK11081
tRNA guanosine-2'-O-methyltransferase; Provisional
 136-258 5.52e-19

tRNA guanosine-2'-O-methyltransferase; Provisional


Pssm-ID: 236837 [Multi-domain]  Cd Length: 229  Bit Score: 82.73  E-value: 5.52e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039020415 136 MMEERTDRFRRVVENR--SYSVCLvvEGLSDFGNISAAFRSADALGIQSVHVVSCDSSKRYNGNrhVSMGAEKWLDIEFW 213
Cdd:PRK11081    1 MNPERYARICEMLARRqpDLTVCM--EQVHKPHNVSAIIRTADAVGVHEVHAVWPGSRMRTMGS--TAAGSNSWVQVKTH 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1039020415 214 DTPKECFKVLKSRGYRIATTHLGMDTVSIYDMDWSCPTAIVVGNE 258
Cdd:PRK11081   77 RTIGDAVAHLKGQGMQILATHLSDTAVDFREIDYTRPTCILMGQE 121
SpoU-like cd18097
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 155-258 3.68e-17

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349970  Cd Length: 144  Bit Score: 75.68  E-value: 3.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039020415 155 VCLVVEGLSDFGNISAAFRSADALGIQSVHVVSCDSSKRYNGNRHVSMGAEKWLDIEFWDTPKECFKVLKSRGYRIATTH 234
Cdd:cd18097     1 LVVVLDNLRSAHNVGSIFRTADAAGVEKIYLCGYTPTPPHPKVAKTALGAEESVPWEHFEDTLEAVRALKARGYTIIALE 80

                          90       100
                  ....*....|....*....|....
gi 1039020415 235 LGMDTVSIYDMDWSCPTAIVVGNE 258
Cdd:cd18097    81 TTENSVPLHEARLPRPLALVLGNE 104
SpoU-like_family cd18082
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 157-260 3.27e-16

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349955  Cd Length: 145  Bit Score: 73.41  E-value: 3.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039020415 157 LVVEGLSDFGNISAAFRSADALGIQSVHVVScDSSKRYNGNR-HVSMGAEKWLDIEFWDTPKECFKVLKSRGYRIATTHL 235
Cdd:cd18082     2 LVLDNIRSPGNIGSIFRTADAFGVEKIYLVG-PTADIFDPKAkRTSRGTHFSVPYERVDNFEEYLKSLKEEGYPLIGLEL 80

                          90       100
                  ....*....|....*....|....*..
gi 1039020415 236 GMDTVSIYDMDWSC--PTAIVVGNEGR 260
Cdd:cd18082    81 TDGSIPLSEFKFKKpkKIALIFGNERS 107
SpoU-like_rRNA-MTase cd18095
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 156-260 3.55e-16

SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349968  Cd Length: 143  Bit Score: 73.23  E-value: 3.55e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039020415 156 CLVVEGLSDFGNISAAFRSADALGIQSVhVVSCDSSKRYNGN--RhVSMGAEKWLDIEFWDTPKECFKVLKSRGYRIATT 233
Cdd:cd18095     2 VLVLDGVQDPGNLGTIIRTAAAFGVDGV-ILSKGTVDPYNPKvvR-ASMGALFRLPIIRVDDLEELLEELKEAGYKVVAA 79

                          90       100
                  ....*....|....*....|....*..
gi 1039020415 234 HLGmDTVSIYDMDWSCPTAIVVGNEGR 260
Cdd:cd18095    80 DLD-GGSSLYDLDLPKPVALVLGNEGN 105
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 157-260 5.46e-15

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 72.54  E-value: 5.46e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039020415 157 LVVEGLSDFGNISAAFRSADALGIQSVhVVSCDSSKRYNGN--RhVSMGAEKWLDIEFWDTPKECFKVLKSRGYRIATTH 234
Cdd:COG0566   118 LVLDGVQDPGNLGAILRSAAAFGVDGV-ILPKRRADPYNPKvvR-ASAGALFHVPVARVTNLADALEELKEAGFWVVGTD 195

                          90       100
                  ....*....|....*....|....*.
gi 1039020415 235 LGmDTVSIYDMDWSCPTAIVVGNEGR 260
Cdd:COG0566   196 LD-GEASLYEVDLPGPVALVLGNEGK 220
SpoU-like cd18096
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 157-259 3.64e-14

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349969  Cd Length: 140  Bit Score: 67.63  E-value: 3.64e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039020415 157 LVVEGLSDFGNISAAFRSADALGIQSVHVVscdSSKRYngNRHVSMGAEKWLDIEFWDTPKECFKVLKSRGYRIATTHLG 236
Cdd:cd18096     3 LVLHNVAKRHNIGTIVRSANAFGVKEVHLV---GRRKF--NPFGAMGTDRHVKFRHFDTLAEAKEYLKERGIRLVGVEIV 77

                          90       100
                  ....*....|....*....|...
gi 1039020415 237 MDTVSIYDMDWSCPTAIVVGNEG 259
Cdd:cd18096    78 PGAEPIETHPFPGDTAFVLGNEG 100
SpoU-like_RNA-MTase cd18104
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 157-258 1.38e-11

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349977  Cd Length: 146  Bit Score: 60.67  E-value: 1.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039020415 157 LVVEGLSDFGNISAAFRSADALGIQSVHVvsCDS-SKRYNGN--RhVSMGAEKWLDIeFWDTPKECFKVLKSRGYRIATT 233
Cdd:cd18104     3 LVLEGLEKPGNLGAILRSADAAGADAVIL--CDPkTDLFNPNviR-ASLGAVFTLPV-AEASSEETLAWLKENKIRILAT 78

                          90       100
                  ....*....|....*....|....*
gi 1039020415 234 HLGMDTvSIYDMDWSCPTAIVVGNE 258
Cdd:cd18104    79 TPKAEK-LYYEADLRGPIAIVVGSE 102
SpoU-like_RlmB cd18103
SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the ...
 157-260 2.09e-10

SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349976  Cd Length: 143  Bit Score: 57.39  E-value: 2.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039020415 157 LVVEGLSDFGNISAAFRSADALGIQSVhVVSCDSSKRYNGN-RHVSMGAEKWLDIEFWDTPKECFKVLKSRGYRIATTHL 235
Cdd:cd18103     3 LILDGITDPHNLGAIIRSAEAFGVDGV-IIPKRRSAPLTPTvAKASAGALEHLPIARVTNLARALEELKEAGFWIYGADG 81

                          90       100
                  ....*....|....*....|....*
gi 1039020415 236 GmDTVSIYDMDWSCPTAIVVGNEGR 260
Cdd:cd18103    82 E-AEKSLYDVDLTGPLALVLGSEGK 105
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 119-260 3.83e-10

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 58.51  E-value: 3.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039020415 119 GEVHlssREVLEAVSPHMMEERTDrFRRVVENRSYSVCLVVEGLSDFGNISAAFRSADALGIQSVhVVSCDSSKRYN-GN 197
Cdd:TIGR00186  59 GGNH---QGIAAKVKPILYKDLND-LYKTAKSKKQPFLLILDEITDPHNLGAILRTAEAFGVDGV-ILPKRRSAPLNsTV 133

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039020415 198 RHVSMGAEKWLDIEFWDTPKECFKVLKSRGYRI-ATTHLGMDTvsIYDMDWSCPTAIVVGNEGR 260
Cdd:TIGR00186 134 VKTSSGAVEYVPLARVTNLSRTITKLKESGFWTvGTDLDAQDT--LYQVKLTKPLALVVGNEGE 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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