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Conserved domains on  [gi|1039019591|gb|ANM68733|]
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receptor like protein 56 [Arabidopsis thaliana]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 13746049)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 41-854 2.42e-62

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 228.96  E-value: 2.42e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591  41 LPTWtnDTKSDCCQWENIKCNRTSRrltglslytsyyleisllnlsllhpfeeVRSLDLSNSRLNGLVDdvegyKSLRRL 120
Cdd:PLN00113   48 LSNW--NSSADVCLWQGITCNNSSR----------------------------VVSIDLSGKNISGKIS-----SAIFRL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 121 RNLQILNFSSNEFNNSI-FPFLNAATSLTTLSLRRNNMYGPIPLKelkNLTNLELLDLSGNRIDGSMPvREFPYLKKLKA 199
Cdd:PLN00113   93 PYIQTINLSNNQLSGPIpDDIFTTSSSLRYLNLSNNNFTGSIPRG---SIPNLETLDLSNNMLSGEIP-NDIGSFSSLKV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 200 LDLSSNGIYSSMEwQGLKNLTNLEVLSLGYNYFDGPIPIEVfCEMKNLQELDLRGINFVGQLPLCFGNLNKLRFLDLSSN 279
Cdd:PLN00113  169 LDLGGNVLVGKIP-NSLTNLTSLEFLTLASNQLVGQIPREL-GQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 280 QLTGNIPPSFSSLESLEYLSLSDNSFEGffslnpltnltklkvfifsskddmvqvkiestwqplfqlsvlvlrlcsleKI 359
Cdd:PLN00113  247 NLTGPIPSSLGNLKNLQYLFLYQNKLSG--------------------------------------------------PI 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 360 PNFLMYQKNLHVVDLSGNRISGIIPtwllennpELeVLQLKNnsftifqmptsvhnLQVLDFSENNIGGLFPDNFGRvLP 439
Cdd:PLN00113  277 PPSIFSLQKLISLDLSDNSLSGEIP--------EL-VIQLQN--------------LEILHLFSNNFTGKIPVALTS-LP 332

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 440 NLVHMNGSNNGFQGNFPSSMGEMYNISFLDLSYNNLSGELPQSFVSSCfSLSILQLSHNKFSGHFLPRQTNFTSLIVLRI 519
Cdd:PLN00113  333 RLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSG-NLFKLILFSNSLEGEIPKSLGACRSLRRVRL 411

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 520 NNNLFTGKIGVGLLTLvdlcildmsnnflegelpplllvfEYLNFLDLSgnllsgalpshvsldnvlflhNNNFTGPIPD 599
Cdd:PLN00113  412 QDNSFSGELPSEFTKL------------------------PLVYFLDIS---------------------NNNLQGRINS 446

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 600 TF--LGSIQILDLRNNKLSGNIPQFVDTqdisflllrgnsltgyipstlcefSKMRLLDLSDNKLNGFIPSCFnnlsfgl 677
Cdd:PLN00113  447 RKwdMPSLQMLSLARNKFFGGLPDSFGS------------------------KRLENLDLSRNQFSGAVPRKL------- 495

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 678 arkeeitnyyvavalesfylgfykstfvvenfrldysnyfeidvkfatkqrydsyigafqfseGTLNSMYGLDLSSNELS 757
Cdd:PLN00113  496 ---------------------------------------------------------------GSLSELMQLKLSENKLS 512

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 758 GVIPAELGDLFKLRALNLSHNFLSSHIPDSFSKLQDIESLDLSYNMLQGSIPHQLTNLTSLAIFNVSYNNLSGIIPQGKQ 837
Cdd:PLN00113  513 GEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPSTGA 592

                         810
                  ....*....|....*..
gi 1039019591 838 FNTFDENSYLGNPLLCG 854
Cdd:PLN00113  593 FLAINASAVAGNIDLCG 609
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 17-61 7.89e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 34.96  E-value: 7.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1039019591  17 ERKALLELKKFVMSRceeceyDSVLPTWTNDTkSDCCQWENIKCN 61
Cdd:pfam08263   4 DGQALLAFKSSLNDP------PGALSSWNSSS-SDPCSWTGVTCD 41
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 41-854 2.42e-62

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 228.96  E-value: 2.42e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591  41 LPTWtnDTKSDCCQWENIKCNRTSRrltglslytsyyleisllnlsllhpfeeVRSLDLSNSRLNGLVDdvegyKSLRRL 120
Cdd:PLN00113   48 LSNW--NSSADVCLWQGITCNNSSR----------------------------VVSIDLSGKNISGKIS-----SAIFRL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 121 RNLQILNFSSNEFNNSI-FPFLNAATSLTTLSLRRNNMYGPIPLKelkNLTNLELLDLSGNRIDGSMPvREFPYLKKLKA 199
Cdd:PLN00113   93 PYIQTINLSNNQLSGPIpDDIFTTSSSLRYLNLSNNNFTGSIPRG---SIPNLETLDLSNNMLSGEIP-NDIGSFSSLKV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 200 LDLSSNGIYSSMEwQGLKNLTNLEVLSLGYNYFDGPIPIEVfCEMKNLQELDLRGINFVGQLPLCFGNLNKLRFLDLSSN 279
Cdd:PLN00113  169 LDLGGNVLVGKIP-NSLTNLTSLEFLTLASNQLVGQIPREL-GQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 280 QLTGNIPPSFSSLESLEYLSLSDNSFEGffslnpltnltklkvfifsskddmvqvkiestwqplfqlsvlvlrlcsleKI 359
Cdd:PLN00113  247 NLTGPIPSSLGNLKNLQYLFLYQNKLSG--------------------------------------------------PI 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 360 PNFLMYQKNLHVVDLSGNRISGIIPtwllennpELeVLQLKNnsftifqmptsvhnLQVLDFSENNIGGLFPDNFGRvLP 439
Cdd:PLN00113  277 PPSIFSLQKLISLDLSDNSLSGEIP--------EL-VIQLQN--------------LEILHLFSNNFTGKIPVALTS-LP 332

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 440 NLVHMNGSNNGFQGNFPSSMGEMYNISFLDLSYNNLSGELPQSFVSSCfSLSILQLSHNKFSGHFLPRQTNFTSLIVLRI 519
Cdd:PLN00113  333 RLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSG-NLFKLILFSNSLEGEIPKSLGACRSLRRVRL 411

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 520 NNNLFTGKIGVGLLTLvdlcildmsnnflegelpplllvfEYLNFLDLSgnllsgalpshvsldnvlflhNNNFTGPIPD 599
Cdd:PLN00113  412 QDNSFSGELPSEFTKL------------------------PLVYFLDIS---------------------NNNLQGRINS 446

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 600 TF--LGSIQILDLRNNKLSGNIPQFVDTqdisflllrgnsltgyipstlcefSKMRLLDLSDNKLNGFIPSCFnnlsfgl 677
Cdd:PLN00113  447 RKwdMPSLQMLSLARNKFFGGLPDSFGS------------------------KRLENLDLSRNQFSGAVPRKL------- 495

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 678 arkeeitnyyvavalesfylgfykstfvvenfrldysnyfeidvkfatkqrydsyigafqfseGTLNSMYGLDLSSNELS 757
Cdd:PLN00113  496 ---------------------------------------------------------------GSLSELMQLKLSENKLS 512

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 758 GVIPAELGDLFKLRALNLSHNFLSSHIPDSFSKLQDIESLDLSYNMLQGSIPHQLTNLTSLAIFNVSYNNLSGIIPQGKQ 837
Cdd:PLN00113  513 GEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPSTGA 592

                         810
                  ....*....|....*..
gi 1039019591 838 FNTFDENSYLGNPLLCG 854
Cdd:PLN00113  593 FLAINASAVAGNIDLCG 609
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-440 1.67e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 1.67e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591  70 LSLYTSYYLEISLLNLSLLHPFEEVRSLDLSNSRLNGLVDDVEGYKSLRRLRNLQILNFSSNEFnnsifpfLNAATSLTT 149
Cdd:COG4886    45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLES 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 150 LSLRRNNMyGPIPlKELKNLTNLELLDLSGNRIDgSMPvREFPYLKKLKALDLSSNGIySSMEwQGLKNLTNLEVLSLGY 229
Cdd:COG4886   118 LDLSGNQL-TDLP-EELANLTNLKELDLSNNQLT-DLP-EPLGNLTNLKSLDLSNNQL-TDLP-EELGNLTNLKELDLSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 230 NYFDgPIPiEVFCEMKNLQELDLRGiNFVGQLPLCFGNLNKLRFLDLSSNQLTGniPPSFSSLESLEYLSLSDNSFEGFF 309
Cdd:COG4886   192 NQIT-DLP-EPLGNLTNLEELDLSG-NQLTDLPEPLANLTNLETLDLSNNQLTD--LPELGNLTNLEELDLSNNQLTDLP 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 310 SLNPLTNLTKLKVFIFSSKDDMVQVKIESTWQPLFQLSVLVLRLCSLEKIPNFLMYQKNLHVVDLSGNRISGIIPTWLLE 389
Cdd:COG4886   267 PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1039019591 390 NNPELEVLQLKNNSFTIFQMPTSVHNLQVLDFSENNIGGLFPDNFGRVLPN 440
Cdd:COG4886   347 LALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 165-322 1.66e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 1.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 165 ELKNLTNLELLDLSGNRIDgSMPvrEFPYLKKLKALDLSSNGIySSMEwqGLKNLTNLEVLSLGYNYfdgpipIEVFC-- 242
Cdd:cd21340    19 NLSLCKNLKVLYLYDNKIT-KIE--NLEFLTNLTHLYLQNNQI-EKIE--NLENLVNLKKLYLGGNR------ISVVEgl 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 243 -EMKNLQELDLRGINFVGQLPLCFGN------LNKLRFLDLSSNQLTgnIPPSFSSLESLEYLSLSDNSFEGF----FSL 311
Cdd:cd21340    87 eNLTNLEELHIENQRLPPGEKLTFDPrslaalSNSLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISDLeellDLL 164

                         170
                  ....*....|.
gi 1039019591 312 NPLTNLTKLKV 322
Cdd:cd21340   165 SSWPSLRELDL 175
LRR_8 pfam13855
Leucine rich repeat;
769-828 1.52e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.52e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 769 KLRALNLSHNFLSSHIPDSFSKLQDIESLDLSYNMLQGSIPHQLTNLTSLAIFNVSYNNL 828
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 17-61 7.89e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 34.96  E-value: 7.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1039019591  17 ERKALLELKKFVMSRceeceyDSVLPTWTNDTkSDCCQWENIKCN 61
Cdd:pfam08263   4 DGQALLAFKSSLNDP------PGALSSWNSSS-SDPCSWTGVTCD 41
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 41-854 2.42e-62

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 228.96  E-value: 2.42e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591  41 LPTWtnDTKSDCCQWENIKCNRTSRrltglslytsyyleisllnlsllhpfeeVRSLDLSNSRLNGLVDdvegyKSLRRL 120
Cdd:PLN00113   48 LSNW--NSSADVCLWQGITCNNSSR----------------------------VVSIDLSGKNISGKIS-----SAIFRL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 121 RNLQILNFSSNEFNNSI-FPFLNAATSLTTLSLRRNNMYGPIPLKelkNLTNLELLDLSGNRIDGSMPvREFPYLKKLKA 199
Cdd:PLN00113   93 PYIQTINLSNNQLSGPIpDDIFTTSSSLRYLNLSNNNFTGSIPRG---SIPNLETLDLSNNMLSGEIP-NDIGSFSSLKV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 200 LDLSSNGIYSSMEwQGLKNLTNLEVLSLGYNYFDGPIPIEVfCEMKNLQELDLRGINFVGQLPLCFGNLNKLRFLDLSSN 279
Cdd:PLN00113  169 LDLGGNVLVGKIP-NSLTNLTSLEFLTLASNQLVGQIPREL-GQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 280 QLTGNIPPSFSSLESLEYLSLSDNSFEGffslnpltnltklkvfifsskddmvqvkiestwqplfqlsvlvlrlcsleKI 359
Cdd:PLN00113  247 NLTGPIPSSLGNLKNLQYLFLYQNKLSG--------------------------------------------------PI 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 360 PNFLMYQKNLHVVDLSGNRISGIIPtwllennpELeVLQLKNnsftifqmptsvhnLQVLDFSENNIGGLFPDNFGRvLP 439
Cdd:PLN00113  277 PPSIFSLQKLISLDLSDNSLSGEIP--------EL-VIQLQN--------------LEILHLFSNNFTGKIPVALTS-LP 332

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 440 NLVHMNGSNNGFQGNFPSSMGEMYNISFLDLSYNNLSGELPQSFVSSCfSLSILQLSHNKFSGHFLPRQTNFTSLIVLRI 519
Cdd:PLN00113  333 RLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSG-NLFKLILFSNSLEGEIPKSLGACRSLRRVRL 411

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 520 NNNLFTGKIGVGLLTLvdlcildmsnnflegelpplllvfEYLNFLDLSgnllsgalpshvsldnvlflhNNNFTGPIPD 599
Cdd:PLN00113  412 QDNSFSGELPSEFTKL------------------------PLVYFLDIS---------------------NNNLQGRINS 446

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 600 TF--LGSIQILDLRNNKLSGNIPQFVDTqdisflllrgnsltgyipstlcefSKMRLLDLSDNKLNGFIPSCFnnlsfgl 677
Cdd:PLN00113  447 RKwdMPSLQMLSLARNKFFGGLPDSFGS------------------------KRLENLDLSRNQFSGAVPRKL------- 495

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 678 arkeeitnyyvavalesfylgfykstfvvenfrldysnyfeidvkfatkqrydsyigafqfseGTLNSMYGLDLSSNELS 757
Cdd:PLN00113  496 ---------------------------------------------------------------GSLSELMQLKLSENKLS 512

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 758 GVIPAELGDLFKLRALNLSHNFLSSHIPDSFSKLQDIESLDLSYNMLQGSIPHQLTNLTSLAIFNVSYNNLSGIIPQGKQ 837
Cdd:PLN00113  513 GEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPSTGA 592

                         810
                  ....*....|....*..
gi 1039019591 838 FNTFDENSYLGNPLLCG 854
Cdd:PLN00113  593 FLAINASAVAGNIDLCG 609
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
70-440 1.67e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 1.67e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591  70 LSLYTSYYLEISLLNLSLLHPFEEVRSLDLSNSRLNGLVDDVEGYKSLRRLRNLQILNFSSNEFnnsifpfLNAATSLTT 149
Cdd:COG4886    45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLES 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 150 LSLRRNNMyGPIPlKELKNLTNLELLDLSGNRIDgSMPvREFPYLKKLKALDLSSNGIySSMEwQGLKNLTNLEVLSLGY 229
Cdd:COG4886   118 LDLSGNQL-TDLP-EELANLTNLKELDLSNNQLT-DLP-EPLGNLTNLKSLDLSNNQL-TDLP-EELGNLTNLKELDLSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 230 NYFDgPIPiEVFCEMKNLQELDLRGiNFVGQLPLCFGNLNKLRFLDLSSNQLTGniPPSFSSLESLEYLSLSDNSFEGFF 309
Cdd:COG4886   192 NQIT-DLP-EPLGNLTNLEELDLSG-NQLTDLPEPLANLTNLETLDLSNNQLTD--LPELGNLTNLEELDLSNNQLTDLP 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 310 SLNPLTNLTKLKVFIFSSKDDMVQVKIESTWQPLFQLSVLVLRLCSLEKIPNFLMYQKNLHVVDLSGNRISGIIPTWLLE 389
Cdd:COG4886   267 PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1039019591 390 NNPELEVLQLKNNSFTIFQMPTSVHNLQVLDFSENNIGGLFPDNFGRVLPN 440
Cdd:COG4886   347 LALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-320 6.23e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 99.62  E-value: 6.23e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591  52 CCQWENIKCNRTSRRLTGLSLYTSYYLEISLLNLSLLHPFEEVRSLDLSNSRLNGLVDDVEGYKSLRRLRNLQILNFSSN 131
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 132 EFNNSIFPF--LNAATSLTTLSLRRNNmygpiplkELKNLTNLELLDLSGNRIDgSMPVrEFPYLKKLKALDLSSNGIYS 209
Cdd:COG4886    81 LLSLLLLGLtdLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLT-DLPE-ELANLTNLKELDLSNNQLTD 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 210 SMEWqgLKNLTNLEVLSLGYNYFDGpIPiEVFCEMKNLQELDLRGiNFVGQLPLCFGNLNKLRFLDLSSNQLTgNIPPSF 289
Cdd:COG4886   151 LPEP--LGNLTNLKSLDLSNNQLTD-LP-EELGNLTNLKELDLSN-NQITDLPEPLGNLTNLEELDLSGNQLT-DLPEPL 224

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1039019591 290 SSLESLEYLSLSDNSFEGFFSLNPLTNLTKL 320
Cdd:COG4886   225 ANLTNLETLDLSNNQLTDLPELGNLTNLEEL 255
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
120-521 1.31e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 1.31e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 120 LRNLQILNFSSNEFNNSIFPFLNAATSLTTLSLRRNNMYGPIPLKELKNLTNLELLDLSGNRIDGSMPVREFPYLKKLKA 199
Cdd:COG4886    21 LTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 200 LDLSSNgiyssmewQGLKNLTNLEVLSLGYNYFDGpIPIEvFCEMKNLQELDLRGiNFVGQLPLCFGNLNKLRFLDLSSN 279
Cdd:COG4886   101 LDLSGN--------EELSNLTNLESLDLSGNQLTD-LPEE-LANLTNLKELDLSN-NQLTDLPEPLGNLTNLKSLDLSNN 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 280 QLTgNIPPSFSSLESLEYLSLSDNSFEGFFSlnPLTNLTKLKVfifsskddmvqvkiestwqplfqlsvLVLRLCSLEKI 359
Cdd:COG4886   170 QLT-DLPEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEE--------------------------LDLSGNQLTDL 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 360 PNFLMYQKNLHVVDLSGNRISGIIPtwlLENNPELEVLQLKNNSFTIFQMPTSVHNLQVLDFSENNIGGLFPDNFGRVLP 439
Cdd:COG4886   221 PEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLG 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 440 NLVHMNGSNNGFQGNFPSSMGEMYNISFLDLSYNNLSGELPQSFVSSCFSLSILQLSHNKFSGHFLPRQTNFTSLIVLRI 519
Cdd:COG4886   298 LNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEA 377


                  ..
gi 1039019591 520 NN 521
Cdd:COG4886   378 TL 379
PLN03150 PLN03150
hypothetical protein; Provisional
 748-861 6.18e-19

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 91.80  E-value: 6.18e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 748 GLDLSSNELSGVIPAELGDLFKLRALNLSHNFLSSHIPDSFSKLQDIESLDLSYNMLQGSIPHQLTNLTSLAIFNVSYNN 827
Cdd:PLN03150  422 GLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNS 501

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1039019591 828 LSGIIP--------QGKQFNTFDensylgNPLLCGPPTDTSC 861
Cdd:PLN03150  502 LSGRVPaalggrllHRASFNFTD------NAGLCGIPGLRAC 537
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
749-831 6.10e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.26  E-value: 6.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 749 LDLSSNELSGvIPAELGDLFKLRALNLSHNFLSShIPDSFSKLQDIESLDLSYNMLQgSIPHQLTNLTSLAIFNVSYNNL 828
Cdd:COG4886   164 LDLSNNQLTD-LPEELGNLTNLKELDLSNNQITD-LPEPLGNLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQL 240


                  ...
gi 1039019591 829 SGI 831
Cdd:COG4886   241 TDL 243
PLN03150 PLN03150
hypothetical protein; Provisional
 743-831 6.99e-10

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 62.91  E-value: 6.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 743 LNSMYGLDLSSNELSGVIPAELGDLFKLRALNLSHNFLSSHIPDSFSKLQDIESLDLSYNMLQGSIPHQL-TNLTSLAIF 821
Cdd:PLN03150  441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALgGRLLHRASF 520

                          90
                  ....*....|.
gi 1039019591 822 NVSYN-NLSGI 831
Cdd:PLN03150  521 NFTDNaGLCGI 531
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
509-831 2.71e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 2.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 509 TNFTSLIVLRINNNLFTGKIGVGLLTLVDLCILDMSNNFLEGELPPLLLVFEYLNFLDLSGNLLSGALPSHVSLDNVLFL 588
Cdd:COG4886    19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 589 HNNNFTGPIPDTFLGSIQILDLRNNKLSGNIPQFVDTQDISFLLLRGNSLTgYIPSTLCEFSKMRLLDLSDNKLNGfIPS 668
Cdd:COG4886    99 TELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLTD-LPE 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 669 CFNNLSfglarkeeitnyyvavALESfylgfykstfvvenfrldysnyfeidvkfatkqrydsyigafqfsegtlnsmyg 748
Cdd:COG4886   177 ELGNLT----------------NLKE------------------------------------------------------ 186

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 749 LDLSSNELSgVIPAELGDLFKLRALNLSHNFLSShIPDSFSKLQDIESLDLSYNMLQgSIPhQLTNLTSLAIFNVSYNNL 828
Cdd:COG4886   187 LDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLTD-LPEPLANLTNLETLDLSNNQLT-DLP-ELGNLTNLEELDLSNNQL 262


                  ...
gi 1039019591 829 SGI 831
Cdd:COG4886   263 TDL 265
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
297-733 4.78e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 4.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 297 YLSLSDNSFEGFFSLNPLTNLTKLKVFIFSSKDDMVQVKIESTWQPLFQLSVLVLRLCSLEKIPNFLMYQKNLHVVDLSG 376
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 377 NRISGIIPTWLLENNPELEVLQLKNNSFTifqmpTSVHNLQVLDFSENNIGGLfPDNFGRvLPNLVHMNGSNNGFQgNFP 456
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGNEEL-----SNLTNLESLDLSGNQLTDL-PEELAN-LTNLKELDLSNNQLT-DLP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 457 SSMGEMYNISFLDLSYNNLSgELPQSFvSSCFSLSILQLSHNKFSghFLPRQ-TNFTSLIVLRINNNLftgkigvglLTL 535
Cdd:COG4886   153 EPLGNLTNLKSLDLSNNQLT-DLPEEL-GNLTNLKELDLSNNQIT--DLPEPlGNLTNLEELDLSGNQ---------LTD 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 536 VDLCILDMSNnflegelpplllvfeyLNFLDLSGNLLSgALPSHVSLDN--VLFLHNNNFTGPIPDTFLGSIQILDLRNN 613
Cdd:COG4886   220 LPEPLANLTN----------------LETLDLSNNQLT-DLPELGNLTNleELDLSNNQLTDLPPLANLTNLKTLDLSNN 282

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 614 KLSGNIPQFVDTQDISFLLLRGNSLTGYIPSTLCEFSKMRLLDLSDNKLNGFIPSCFNNLSFGLARKEEITNYYVAVALE 693
Cdd:COG4886   283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1039019591 694 SFYLGFYKSTFVVENFRLDYSNYFEIDVKFATKQRYDSYI 733
Cdd:COG4886   363 LTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
PLN03150 PLN03150
hypothetical protein; Provisional
 244-307 1.54e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 58.29  E-value: 1.54e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039019591 244 MKNLQELDLRGINFVGQLPLCFGNLNKLRFLDLSSNQLTGNIPPSFSSLESLEYLSLSDNSFEG 307
Cdd:PLN03150  441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSG 504
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 165-322 1.66e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 1.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 165 ELKNLTNLELLDLSGNRIDgSMPvrEFPYLKKLKALDLSSNGIySSMEwqGLKNLTNLEVLSLGYNYfdgpipIEVFC-- 242
Cdd:cd21340    19 NLSLCKNLKVLYLYDNKIT-KIE--NLEFLTNLTHLYLQNNQI-EKIE--NLENLVNLKKLYLGGNR------ISVVEgl 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 243 -EMKNLQELDLRGINFVGQLPLCFGN------LNKLRFLDLSSNQLTgnIPPSFSSLESLEYLSLSDNSFEGF----FSL 311
Cdd:cd21340    87 eNLTNLEELHIENQRLPPGEKLTFDPrslaalSNSLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISDLeellDLL 164

                         170
                  ....*....|.
gi 1039019591 312 NPLTNLTKLKV 322
Cdd:cd21340   165 SSWPSLRELDL 175
PLN03150 PLN03150
hypothetical protein; Provisional
 424-502 3.29e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 57.52  E-value: 3.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 424 NNIG--GLFPDNFGRvLPNLVHMNGSNNGFQGNFPSSMGEMYNISFLDLSYNNLSGELPQSfVSSCFSLSILQLSHNKFS 501
Cdd:PLN03150  426 DNQGlrGFIPNDISK-LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPES-LGQLTSLRILNLNGNSLS 503


                  .
gi 1039019591 502 G 502
Cdd:PLN03150  504 G 504
PLN03150 PLN03150
hypothetical protein; Provisional
 94-187 5.19e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 56.75  E-value: 5.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591  94 VRSLDLSNSRLNGLVDDvegykSLRRLRNLQILNFSSNEFNNSIFPFLNAATSLTTLSLRRNNMYGPIPlKELKNLTNLE 173
Cdd:PLN03150  420 IDGLGLDNQGLRGFIPN-----DISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIP-ESLGQLTSLR 493

                          90
                  ....*....|....
gi 1039019591 174 LLDLSGNRIDGSMP 187
Cdd:PLN03150  494 ILNLNGNSLSGRVP 507
PLN03150 PLN03150
hypothetical protein; Provisional
 734-787 6.21e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 56.36  E-value: 6.21e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039019591 734 GAFQFSEGTLNSMYGLDLSSNELSGVIPAELGDLFKLRALNLSHNFLSSHIPDS 787
Cdd:PLN03150  456 GNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAA 509
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
368-788 9.23e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.32  E-value: 9.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 368 NLHVVDLSGNRISGIIPTWLLENNPELEVLQLKNNSFTIFQMPTSVHNLQVLDFSENNIGGLFPDNFGRVLPNLVHMNGS 447
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 448 NNGFQGNFPSSMGEMYNISFLDLSYNNLSGELPQsfvsscfsLSILQLSHNKFSGhfLPRQ-TNFTSLIVLRINNNLFTg 526
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTN--------LESLDLSGNQLTD--LPEElANLTNLKELDLSNNQLT- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 527 KIGVGLLTLVDLCILDMSNNFLEGELPPLLLvFEYLNFLDLSGNLLSgALPSHVS-LDN--VLFLHNNNFTgPIPDTF-- 601
Cdd:COG4886   150 DLPEPLGNLTNLKSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQIT-DLPEPLGnLTNleELDLSGNQLT-DLPEPLan 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 602 LGSIQILDLRNNKLSgNIPQFVDTQDISFLLLRGNSLTGYipSTLCEFSKMRLLDLSDNKLNGFIPSCFNNLSFGLARKE 681
Cdd:COG4886   227 LTNLETLDLSNNQLT-DLPELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 682 EITNYYVAVALESFYLGFYKSTFVVENFRLDYSNYFEIDVKFATKQRYDSYIGAFQFSEGTLNSMYGLDLSSNELSGVIP 761
Cdd:COG4886   304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                         410       420
                  ....*....|....*....|....*..
gi 1039019591 762 AELGDLFKLRALNLSHNFLSSHIPDSF 788
Cdd:COG4886   384 LLLLTLLLLLLTTTAGVLLLTLALLDA 410
PLN03150 PLN03150
hypothetical protein; Provisional
 250-320 1.55e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 55.21  E-value: 1.55e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039019591 250 LDLRGINfvGQLPLCFGNLNKLRFLDLSSNQLTGNIPPSFSSLESLEYLSLSDNSFEGFF--SLNPLTNLTKL 320
Cdd:PLN03150  425 LDNQGLR--GFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIpeSLGQLTSLRIL 495
PLN03150 PLN03150
hypothetical protein; Provisional
 414-482 3.39e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 54.05  E-value: 3.39e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039019591 414 HNLQVLDFSENNIGGLFPDNFGRVlPNLVHMNGSNNGFQGNFPSSMGEMYNISFLDLSYNNLSGELPQS 482
Cdd:PLN03150  442 RHLQSINLSGNSIRGNIPPSLGSI-TSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAA 509
PLN03150 PLN03150
hypothetical protein; Provisional
 586-668 7.58e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.90  E-value: 7.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 586 LFLHNNNFTGPIPDTF--LGSIQILDLRNNKLSGNIPQFVDT-QDISFLLLRGNSLTGYIPSTLCEFSKMRLLDLSDNKL 662
Cdd:PLN03150  423 LGLDNQGLRGFIPNDIskLRHLQSINLSGNSIRGNIPPSLGSiTSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502


                  ....*.
gi 1039019591 663 NGFIPS 668
Cdd:PLN03150  503 SGRVPA 508
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 245-481 1.47e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.20  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 245 KNLQELDLRGIN------FVGQLPLCFGNLNKLRFLDLSSNQLTGNIPPSFSSL---ESLEYLSLSDNSFEgffslnplt 315
Cdd:cd00116    51 PSLKELCLSLNEtgriprGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLG--------- 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 316 nltklkvfifsskDDMVQVKIESTWQPLFQLSVLVLRLCSL-----EKIPNFLMYQKNLHVVDLSGNRI--SGIIPTWL- 387
Cdd:cd00116   122 -------------DRGLRLLAKGLKDLPPALEKLVLGRNRLegascEALAKALRANRDLKELNLANNGIgdAGIRALAEg 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 388 LENNPELEVLQLKNNSFT------IFQMPTSVHNLQVLDFSENNIGGL----FPDNFGRVLPNLVHMNGSNN-----GFQ 452
Cdd:cd00116   189 LKANCNLEVLDLNNNGLTdegasaLAETLASLKSLEVLNLGDNNLTDAgaaaLASALLSPNISLLTLSLSCNditddGAK 268

                         250       260
                  ....*....|....*....|....*....
gi 1039019591 453 gNFPSSMGEMYNISFLDLSYNNLSGELPQ 481
Cdd:cd00116   269 -DLAEVLAEKESLLELDLRGNKFGEEGAQ 296
LRR_8 pfam13855
Leucine rich repeat;
769-828 1.52e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.52e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 769 KLRALNLSHNFLSSHIPDSFSKLQDIESLDLSYNMLQGSIPHQLTNLTSLAIFNVSYNNL 828
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 141-303 1.57e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 1.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 141 LNAATSLTTLSLRRNNMYGpipLKELKNLTNLELLDLSGN---RIDGsmpvreFPYLKKLKALDLSSNGIySSMEwqGLK 217
Cdd:cd21340    20 LSLCKNLKVLYLYDNKITK---IENLEFLTNLTHLYLQNNqieKIEN------LENLVNLKKLYLGGNRI-SVVE--GLE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 218 NLTNLEVLSLGYN--------YFDgpiPIEVFCEMKNLQELDLRGINFVGQLPLcfGNLNKLRFLDLSSNQLT--GNIPP 287
Cdd:cd21340    88 NLTNLEELHIENQrlppgeklTFD---PRSLAALSNSLRVLNISGNNIDSLEPL--APLRNLEQLDASNNQISdlEELLD 162

                         170
                  ....*....|....*.
gi 1039019591 288 SFSSLESLEYLSLSDN 303
Cdd:cd21340   163 LLSSWPSLRELDLTGN 178
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 86-281 1.96e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.82  E-value: 1.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591  86 SLLHPFEEVRSLDLSNSRLNGlvDDVEGY-KSLRRLRNLQILNFSSNEFNN----SIFPFLNAATSLTTLSLRRN--NMY 158
Cdd:cd00116   131 GLKDLPPALEKLVLGRNRLEG--ASCEALaKALRANRDLKELNLANNGIGDagirALAEGLKANCNLEVLDLNNNglTDE 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 159 GPIPLKE-LKNLTNLELLDLSGNRIdGSMPVREF-----PYLKKLKALDLSSNGIyssmewqglknlTNLEVLSLgynyf 232
Cdd:cd00116   209 GASALAEtLASLKSLEVLNLGDNNL-TDAGAAALasallSPNISLLTLSLSCNDI------------TDDGAKDL----- 270

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039019591 233 dgpipIEVFCEMKNLQELDLRGINF-------VGQLPLCFGnlNKLRFLDLSSNQL 281
Cdd:cd00116   271 -----AEVLAEKESLLELDLRGNKFgeegaqlLAESLLEPG--NELESLWVKDDSF 319
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 117-254 2.98e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 2.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 117 LRRLRNLQILNFssneFNNSI--FPFLNAATSLTTLSLRRNNMYgpiPLKELKNLTNLELLDLSGNRI------DGSMPV 188
Cdd:cd21340    20 LSLCKNLKVLYL----YDNKItkIENLEFLTNLTHLYLQNNQIE---KIENLENLVNLKKLYLGGNRIsvveglENLTNL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 189 REFpYLKK----------------------LKALDLSSNGIySSMEwqGLKNLTNLEVLSLGYNYFDGPIPI-EVFCEMK 245
Cdd:cd21340    93 EEL-HIENqrlppgekltfdprslaalsnsLRVLNISGNNI-DSLE--PLAPLRNLEQLDASNNQISDLEELlDLLSSWP 168


                  ....*....
gi 1039019591 246 NLQELDLRG 254
Cdd:cd21340   169 SLRELDLTG 177
PLN03150 PLN03150
hypothetical protein; Provisional
 565-646 6.02e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.20  E-value: 6.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 565 LDLSGNLLSGALPSHVS----LDNvLFLHNNNFTGPIPDTF--LGSIQILDLRNNKLSGNIPQFV-DTQDISFLLLRGNS 637
Cdd:PLN03150  423 LGLDNQGLRGFIPNDISklrhLQS-INLSGNSIRGNIPPSLgsITSLEVLDLSYNSFNGSIPESLgQLTSLRILNLNGNS 501


                  ....*....
gi 1039019591 638 LTGYIPSTL 646
Cdd:PLN03150  502 LSGRVPAAL 510
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 65-282 8.12e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.40  E-value: 8.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591  65 RRLTGLSLYTSYYLEISLLNLSLLHPFEE-----VRSLDLSNSRLnGLVDDVEGYKSLRRLRNLQILNFSSNEFNNSIFP 139
Cdd:COG5238   148 KDPLGGNAVHLLGLAARLGLLAAISMAKAlqnnsVETVYLGCNQI-GDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAE 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 140 FLNAA----TSLTTLSLRRNNM--YGPIPLKE-LKNLTNLELLDLSGNRIDGSMPVREFPYLKK---LKALDLSSNGIyS 209
Cdd:COG5238   227 ILAEAlkgnKSLTTLDLSNNQIgdEGVIALAEaLKNNTTVETLYLSGNQIGAEGAIALAKALQGnttLTSLDLSVNRI-G 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 210 SMEW----QGLKNLTNLEVLSLGYNYF--DGPIPI-EVFCEMKNLQELDLRG--INFVGQLPLC-FGNLNK-LRFLDLSS 278
Cdd:COG5238   306 DEGAialaEGLQGNKTLHTLNLAYNGIgaQGAIALaKALQENTTLHSLDLSDnqIGDEGAIALAkYLEGNTtLRELNLGK 385


                  ....
gi 1039019591 279 NQLT 282
Cdd:COG5238   386 NNIG 389
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 94-282 2.00e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 48.25  E-value: 2.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591  94 VRSLDLSNsrlNGLVDD--VEGYKSLRRLRNLQILNFSSNEFNNS----IFPFLNAATSLTTLSLRRNNM--YGPIPL-K 164
Cdd:COG5238   210 VTTLWLKR---NPIGDEgaEILAEALKGNKSLTTLDLSNNQIGDEgviaLAEALKNNTTVETLYLSGNQIgaEGAIALaK 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 165 ELKNLTNLELLDLSGNRIDGSMPVREFPYLKK---LKALDLSSNGIySSMEW----QGLKNLTNLEVLSLGYNYFdGPIP 237
Cdd:COG5238   287 ALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGnktLHTLNLAYNGI-GAQGAialaKALQENTTLHSLDLSDNQI-GDEG 364

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039019591 238 IEVFCEM----KNLQELDLRG--INFVGQLPLCFG-NLNKLRFLDLSSNQLT 282
Cdd:COG5238   365 AIALAKYlegnTTLRELNLGKnnIGKQGAEALIDAlQTNRLHTLILDGNLIG 416
PLN03150 PLN03150
hypothetical protein; Provisional
 175-288 3.16e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 3.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 175 LDLSGNRIDGSMPvREFPYLKKLKALDLSSNGIYSSMEwQGLKNLTNLEVLSLGYNYFDGPIPIEVfcemknlqeldlrg 254
Cdd:PLN03150  423 LGLDNQGLRGFIP-NDISKLRHLQSINLSGNSIRGNIP-PSLGSITSLEVLDLSYNSFNGSIPESL-------------- 486

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1039019591 255 infvgqlplcfGNLNKLRFLDLSSNQLTGNIPPS 288
Cdd:PLN03150  487 -----------GQLTSLRILNLNGNSLSGRVPAA 509
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 95-305 3.21e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.96  E-value: 3.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591  95 RSLDLSNSRLNGlvDDVEGYKSLRRLRNLQILNFSSNEFNNSIFPFLNAA-----TSLTTLSLRRNNMYGP--IPL-KEL 166
Cdd:cd00116    84 QELDLSDNALGP--DGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGlkdlpPALEKLVLGRNRLEGAscEALaKAL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 167 KNLTNLELLDLSGNRIDGS---MPVREFPYLKKLKALDLSSNGIyssmewqglknlTNLEVLSLGynyfdgpipiEVFCE 243
Cdd:cd00116   162 RANRDLKELNLANNGIGDAgirALAEGLKANCNLEVLDLNNNGL------------TDEGASALA----------ETLAS 219

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039019591 244 MKNLQELDLRG--INFVGQLPLCFGNLN---KLRFLDLSSNQLTGNIPPSFSSL----ESLEYLSLSDNSF 305
Cdd:cd00116   220 LKSLEVLNLGDnnLTDAGAAALASALLSpniSLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKF 290
PLN03150 PLN03150
hypothetical protein; Provisional
 150-266 4.09e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.50  E-value: 4.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 150 LSLRRNNMYGPIPlKELKNLTNLELLDLSGNRIDGSMPVrefpylkklkaldlssngiyssmewqGLKNLTNLEVLSLGY 229
Cdd:PLN03150  423 LGLDNQGLRGFIP-NDISKLRHLQSINLSGNSIRGNIPP--------------------------SLGSITSLEVLDLSY 475

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1039019591 230 NYFDGPIPiEVFCEMKNLQELDLRGINFVGQLPLCFG 266
Cdd:PLN03150  476 NSFNGSIP-ESLGQLTSLRILNLNGNSLSGRVPAALG 511
LRR_8 pfam13855
Leucine rich repeat;
749-804 5.54e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 5.54e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039019591 749 LDLSSNELSGVIPAELGDLFKLRALNLSHNFLSSHIPDSFSKLQDIESLDLSYNML 804
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
246-305 6.29e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 6.29e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 246 NLQELDLRGINFVGQLPLCFGNLNKLRFLDLSSNQLTGNIPPSFSSLESLEYLSLSDNSF 305
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 605-674 1.34e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.58  E-value: 1.34e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039019591 605 IQILDLRNNKLSG----NIPQFVDTQDISfllLRGNSLTGYIPSTLCEFSKMRLLDLSDNKLNGFIPSCFNNLS 674
Cdd:PLN03150  420 IDGLGLDNQGLRGfipnDISKLRHLQSIN---LSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLT 490
PLN03150 PLN03150
hypothetical protein; Provisional
 448-580 2.59e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.81  E-value: 2.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 448 NNGFQGNFPSSMGEMYNISFLDLSYNNLSGELPQSFvSSCFSLSILQLSHNKFSGHfLPRQtnftslivlrinnnlftgk 527
Cdd:PLN03150  427 NQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSL-GSITSLEVLDLSYNSFNGS-IPES------------------- 485

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039019591 528 igVGLLTLvdlcildmsnnflegelpplllvfeyLNFLDLSGNLLSGALPSHV 580
Cdd:PLN03150  486 --LGQLTS--------------------------LRILNLNGNSLSGRVPAAL 510
PLN03150 PLN03150
hypothetical protein; Provisional
 359-460 5.45e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 5.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 359 IPNFLMYQKNLHVVDLSGNRISGIIPTWLlennpelevlqlknnsftifqmpTSVHNLQVLDFSENNIGGLFPDNFGRvL 438
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRGNIPPSL-----------------------GSITSLEVLDLSYNSFNGSIPESLGQ-L 489

                          90       100
                  ....*....|....*....|..
gi 1039019591 439 PNLVHMNGSNNGFQGNFPSSMG 460
Cdd:PLN03150  490 TSLRILNLNGNSLSGRVPAALG 511
LRR_8 pfam13855
Leucine rich repeat;
145-207 1.71e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.71e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039019591 145 TSLTTLSLRRNNMYGpIPLKELKNLTNLELLDLSGNRIDGSMPvREFPYLKKLKALDLSSNGI 207
Cdd:pfam13855   1 PNLRSLDLSNNRLTS-LDDGAFKGLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
196-254 1.76e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.76e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039019591 196 KLKALDLSSNGIySSMEWQGLKNLTNLEVLSLGYNYFDGpIPIEVFCEMKNLQELDLRG 254
Cdd:pfam13855   2 NLRSLDLSNNRL-TSLDDGAFKGLSNLKVLDLSNNLLTT-LSPGAFSGLPSLRYLDLSG 58
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 367-478 1.85e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 367 KNLHVVDLSGNRIS--GIIPTW-LLENNPELEVLQLKNNSFT------IFQMPTSVHNLQVLDFSENNIGGLFPDNFGRV 437
Cdd:COG5238   180 NSVETVYLGCNQIGdeGIEELAeALTQNTTVTTLWLKRNPIGdegaeiLAEALKGNKSLTTLDLSNNQIGDEGVIALAEA 259

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1039019591 438 LPN---LVHMNGSNNGFQGNFPSSMGEMY----NISFLDLSYNNLSGE 478
Cdd:COG5238   260 LKNnttVETLYLSGNQIGAEGAIALAKALqgntTLTSLDLSVNRIGDE 307
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 356-498 3.26e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 3.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 356 LEKIPNFLMYqKNLHVVDLSGNRISGIIPtwlLENNPELEVLQLKNNSFTIFQMPTSVHNLQVLDFSENNIG---GL--- 429
Cdd:cd21340    14 ITKIDNLSLC-KNLKVLYLYDNKITKIEN---LEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISvveGLenl 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 430 --------------------F-PDNFGRVLPNLVHMNGSNNGFQgnFPSSMGEMYNISFLDLSYNNLS--GELpQSFVSS 486
Cdd:cd21340    90 tnleelhienqrlppgekltFdPRSLAALSNSLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISdlEEL-LDLLSS 166

                         170
                  ....*....|..
gi 1039019591 487 CFSLSILQLSHN 498
Cdd:cd21340   167 WPSLRELDLTGN 178
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 17-61 7.89e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 34.96  E-value: 7.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1039019591  17 ERKALLELKKFVMSRceeceyDSVLPTWTNDTkSDCCQWENIKCN 61
Cdd:pfam08263   4 DGQALLAFKSSLNDP------PGALSSWNSSS-SDPCSWTGVTCD 41
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 342-663 9.28e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 9.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 342 PLFQLSVLVLRLCSL-----EKIPNFLMYQKNLHVVDLSGNRISGIIPTWL-----LENNPELEVLQLKNNSFTIFQMP- 410
Cdd:cd00116    21 KLLCLQVLRLEGNTLgeeaaKALASALRPQPSLKELCLSLNETGRIPRGLQsllqgLTKGCGLQELDLSDNALGPDGCGv 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 411 ----TSVHNLQVLDFSENNIGGLFPDNFGRVLPNLVHmngsnngfqgnfpssmgemyNISFLDLSYNNLSGElpqsfvsS 486
Cdd:cd00116   101 leslLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPP--------------------ALEKLVLGRNRLEGA-------S 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 487 CFSLSILqLSHNkfsghflprqtnfTSLIVLRINNNLFTG----KIGVGLLTLVDLCILDMSNNFlegelpplllvfeyl 562
Cdd:cd00116   154 CEALAKA-LRAN-------------RDLKELNLANNGIGDagirALAEGLKANCNLEVLDLNNNG--------------- 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039019591 563 nFLDLSGNLLSGALPShvsldnvlflhnnnftgpipdtfLGSIQILDLRNNKLSGNIPQFVDTQDISF------LLLRGN 636
Cdd:cd00116   205 -LTDEGASALAETLAS-----------------------LKSLEVLNLGDNNLTDAGAAALASALLSPnislltLSLSCN 260

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1039019591 637 SLTGYIPSTLCEF--SKMRL--LDLSDNKLN 663
Cdd:cd00116   261 DITDDGAKDLAEVlaEKESLleLDLRGNKFG 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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