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Conserved domains on  [gi|1039015329|gb|ANM64882|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
52-394 1.33e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.74  E-value: 1.33e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329  52 PPLAVSFcktSRNSQLFAVSDEDGHVSLFNSsskkfassathqenTEKARFRDWIAHYNAIFDISWIKGDSCLLTASGDQ 131
Cdd:COG2319   122 AVRSVAF---SPDGKTLASGSADGTVRLWDL--------------ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 132 TIKVWDVEENKCTGVLIGHTGTVKSMCSHPtNSDLLVSGSRDGCFALWDLRckssshkeefcinsTGmvkgahlsplsKR 211
Cdd:COG2319   185 TVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLA--------------TG-----------KL 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 212 IRRRKAASSSITSVLYVKDEITIATAGApDSALKFWDIRKLKapfaqaspqsdPTNTKEKRSHGIVSLSQDSSGTYLTAS 291
Cdd:COG2319   239 LRTLTGHSGSVRSVAFSPDGRLLASGSA-DGTVRLWDLATGE-----------LLRTLTGHSGGVNSVAFSPDGKLLASG 306

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 292 CKDNRIYLYNtlrLDKG-PVQSFSGcriDSFFVRTM-ISPDGEYVLSGSSDGNAYIWQVNKPQVdPIILKGHDFEVTAVD 369
Cdd:COG2319   307 SDDGTVRLWD---LATGkLLRTLTG---HTGAVRSVaFSPDGKTLASGSDDGTVRLWDLATGEL-LRTLTGHTGAVTSVA 379

                         330       340
                  ....*....|....*....|....*.
gi 1039015329 370 WSPSeiGK-VATASDDFTVRLWNIEN 394
Cdd:COG2319   380 FSPD--GRtLASGSADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
52-394 1.33e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.74  E-value: 1.33e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329  52 PPLAVSFcktSRNSQLFAVSDEDGHVSLFNSsskkfassathqenTEKARFRDWIAHYNAIFDISWIKGDSCLLTASGDQ 131
Cdd:COG2319   122 AVRSVAF---SPDGKTLASGSADGTVRLWDL--------------ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 132 TIKVWDVEENKCTGVLIGHTGTVKSMCSHPtNSDLLVSGSRDGCFALWDLRckssshkeefcinsTGmvkgahlsplsKR 211
Cdd:COG2319   185 TVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLA--------------TG-----------KL 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 212 IRRRKAASSSITSVLYVKDEITIATAGApDSALKFWDIRKLKapfaqaspqsdPTNTKEKRSHGIVSLSQDSSGTYLTAS 291
Cdd:COG2319   239 LRTLTGHSGSVRSVAFSPDGRLLASGSA-DGTVRLWDLATGE-----------LLRTLTGHSGGVNSVAFSPDGKLLASG 306

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 292 CKDNRIYLYNtlrLDKG-PVQSFSGcriDSFFVRTM-ISPDGEYVLSGSSDGNAYIWQVNKPQVdPIILKGHDFEVTAVD 369
Cdd:COG2319   307 SDDGTVRLWD---LATGkLLRTLTG---HTGAVRSVaFSPDGKTLASGSDDGTVRLWDLATGEL-LRTLTGHTGAVTSVA 379

                         330       340
                  ....*....|....*....|....*.
gi 1039015329 370 WSPSeiGK-VATASDDFTVRLWNIEN 394
Cdd:COG2319   380 FSPD--GRtLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 56-391 3.11e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 138.62  E-value: 3.11e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329  56 VSFCKTSRNSQLFAVSDEDGHVSLFNSSSKKFASSAThqentekarfrdwiAHYNAIFDISWIKGDSCLLTASGDQTIKV 135
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK--------------GHTGPVRDVAASADGTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 136 WDVEENKCTGVLIGHTGTVKSMCSHPtNSDLLVSGSRDGCFALWDLRckssshkeefcinsTGmvkgahlsplsKRIRRR 215
Cdd:cd00200    78 WDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVE--------------TG-----------KCLTTL 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 216 KAASSSITSVLYVKDEITIATAGApDSALKFWDIRKLKapfaqaspqsdPTNTKEKRSHGIVSLSQDSSGTYLTASCKDN 295
Cdd:cd00200   132 RGHTDWVNSVAFSPDGTFVASSSQ-DGTIKLWDLRTGK-----------CVATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 296 RIYLYNtlrLDKG-PVQSFSGCriDSFFVRTMISPDGEYVLSGSSDGNAYIWQVNKPQVDPiILKGHDFEVTAVDWSPSe 374
Cdd:cd00200   200 TIKLWD---LSTGkCLGTLRGH--ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ-TLSGHTNSVTSLAWSPD- 272

                         330
                  ....*....|....*..
gi 1039015329 375 IGKVATASDDFTVRLWN 391
Cdd:cd00200   273 GKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
141-180 1.02e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.02e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1039015329 141 NKCTGVLIGHTGTVKSMCSHPtNSDLLVSGSRDGCFALWD 180
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-180 2.31e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.31e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1039015329  142 KCTGVLIGHTGTVKSMCSHPtNSDLLVSGSRDGCFALWD 180
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 332-394 4.72e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.63  E-value: 4.72e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 332 EYVLSGSSDGNAYIWQV--NKPQV----DPI-ILKGHDFEVTAVDWSPSEIGKVATASDDFTVRLWNIEN 394
Cdd:PTZ00420   88 EILASGSEDLTIRVWEIphNDESVkeikDPQcILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIEN 157
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
52-394 1.33e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.74  E-value: 1.33e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329  52 PPLAVSFcktSRNSQLFAVSDEDGHVSLFNSsskkfassathqenTEKARFRDWIAHYNAIFDISWIKGDSCLLTASGDQ 131
Cdd:COG2319   122 AVRSVAF---SPDGKTLASGSADGTVRLWDL--------------ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 132 TIKVWDVEENKCTGVLIGHTGTVKSMCSHPtNSDLLVSGSRDGCFALWDLRckssshkeefcinsTGmvkgahlsplsKR 211
Cdd:COG2319   185 TVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLA--------------TG-----------KL 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 212 IRRRKAASSSITSVLYVKDEITIATAGApDSALKFWDIRKLKapfaqaspqsdPTNTKEKRSHGIVSLSQDSSGTYLTAS 291
Cdd:COG2319   239 LRTLTGHSGSVRSVAFSPDGRLLASGSA-DGTVRLWDLATGE-----------LLRTLTGHSGGVNSVAFSPDGKLLASG 306

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 292 CKDNRIYLYNtlrLDKG-PVQSFSGcriDSFFVRTM-ISPDGEYVLSGSSDGNAYIWQVNKPQVdPIILKGHDFEVTAVD 369
Cdd:COG2319   307 SDDGTVRLWD---LATGkLLRTLTG---HTGAVRSVaFSPDGKTLASGSDDGTVRLWDLATGEL-LRTLTGHTGAVTSVA 379

                         330       340
                  ....*....|....*....|....*.
gi 1039015329 370 WSPSeiGK-VATASDDFTVRLWNIEN 394
Cdd:COG2319   380 FSPD--GRtLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 56-391 3.11e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 138.62  E-value: 3.11e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329  56 VSFCKTSRNSQLFAVSDEDGHVSLFNSSSKKFASSAThqentekarfrdwiAHYNAIFDISWIKGDSCLLTASGDQTIKV 135
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK--------------GHTGPVRDVAASADGTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 136 WDVEENKCTGVLIGHTGTVKSMCSHPtNSDLLVSGSRDGCFALWDLRckssshkeefcinsTGmvkgahlsplsKRIRRR 215
Cdd:cd00200    78 WDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVE--------------TG-----------KCLTTL 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 216 KAASSSITSVLYVKDEITIATAGApDSALKFWDIRKLKapfaqaspqsdPTNTKEKRSHGIVSLSQDSSGTYLTASCKDN 295
Cdd:cd00200   132 RGHTDWVNSVAFSPDGTFVASSSQ-DGTIKLWDLRTGK-----------CVATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 296 RIYLYNtlrLDKG-PVQSFSGCriDSFFVRTMISPDGEYVLSGSSDGNAYIWQVNKPQVDPiILKGHDFEVTAVDWSPSe 374
Cdd:cd00200   200 TIKLWD---LSTGkCLGTLRGH--ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ-TLSGHTNSVTSLAWSPD- 272

                         330
                  ....*....|....*..
gi 1039015329 375 IGKVATASDDFTVRLWN 391
Cdd:cd00200   273 GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
55-398 3.29e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.19  E-value: 3.29e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329  55 AVSFCKTSRNSQLFAVSDEDGHVSLFNSsskkfassathqenTEKARFRDWIAHYNAIFDISWIKGDSCLLTASGDQTIK 134
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDL--------------ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVR 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 135 VWDVEENKCTGVLIGHTGTVKSMCSHPtNSDLLVSGSRDGCFALWDLRckssshkeefcinsTGmvkgahlsplsKRIRR 214
Cdd:COG2319   146 LWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLA--------------TG-----------KLLRT 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 215 RKAASSSITSVLYVKDEITIATAGApDSALKFWDIRKLKAPFAQASPQSDPTNtkekrshgiVSLSQDssGTYLTASCKD 294
Cdd:COG2319   200 LTGHTGAVRSVAFSPDGKLLASGSA-DGTVRLWDLATGKLLRTLTGHSGSVRS---------VAFSPD--GRLLASGSAD 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 295 NRIYLYNtlrLDKG-PVQSFSGcriDSFFVRTM-ISPDGEYVLSGSSDGNAYIWQVNKPQVdPIILKGHDFEVTAVDWSP 372
Cdd:COG2319   268 GTVRLWD---LATGeLLRTLTG---HSGGVNSVaFSPDGKLLASGSDDGTVRLWDLATGKL-LRTLTGHTGAVRSVAFSP 340

                         330       340
                  ....*....|....*....|....*..
gi 1039015329 373 SeiGK-VATASDDFTVRLWNIENNICT 398
Cdd:COG2319   341 D--GKtLASGSDDGTVRLWDLATGELL 365
WD40 COG2319
WD40 repeat [General function prediction only];
103-394 4.63e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.33  E-value: 4.63e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 103 RDWIAHYNAIFDISWIKGDSCLLTASGDQTIKVWDVEENKCTGVLIGHTGTVKSMCSHPtNSDLLVSGSRDGCFALWDLR 182
Cdd:COG2319    72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLA 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 183 ckssshkeefcinsTGmvkgahlsplsKRIRRRKAASSSITSVLYVKDEITIATAGApDSALKFWDIRKLKapfaqaspq 262
Cdd:COG2319   151 --------------TG-----------KLLRTLTGHSGAVTSVAFSPDGKLLASGSD-DGTVRLWDLATGK--------- 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 263 sdPTNTKEKRSHGI--VSLSQDssGTYLTASCKDNRIYLYNtlrLDKG-PVQSFSGcriDSFFVRTM-ISPDGEYVLSGS 338
Cdd:COG2319   196 --LLRTLTGHTGAVrsVAFSPD--GKLLASGSADGTVRLWD---LATGkLLRTLTG---HSGSVRSVaFSPDGRLLASGS 265

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039015329 339 SDGNAYIWQVNKPQVdPIILKGHDFEVTAVDWSPSeiGK-VATASDDFTVRLWNIEN 394
Cdd:COG2319   266 ADGTVRLWDLATGEL-LRTLTGHSGGVNSVAFSPD--GKlLASGSDDGTVRLWDLAT 319
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 143-398 9.38e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.26  E-value: 9.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 143 CTGVLIGHTGTVKSMCSHPtNSDLLVSGSRDGCFALWDLrckssshkeefcinSTGMVkgahlsplskrIRRRKAASSSI 222
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDL--------------ETGEL-----------LRTLKGHTGPV 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 223 TSVLYVKDEITIATAGaPDSALKFWDIRKLKapfaqaspqsdPTNTKEKRSHGIVSLSQDSSGTYLTASCKDNRIYLYNT 302
Cdd:cd00200    55 RDVAASADGTYLASGS-SDKTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 303 lrLDKGPVQSFSGCRIDSFFVRtmISPDGEYVLSGSSDGNAYIWQVNKPQVDpIILKGHDFEVTAVDWSPSEiGKVATAS 382
Cdd:cd00200   123 --ETGKCLTTLRGHTDWVNSVA--FSPDGTFVASSSQDGTIKLWDLRTGKCV-ATLTGHTGEVNSVAFSPDG-EKLLSSS 196

                         250
                  ....*....|....*.
gi 1039015329 383 DDFTVRLWNIENNICT 398
Cdd:cd00200   197 SDGTIKLWDLSTGKCL 212
WD40 COG2319
WD40 repeat [General function prediction only];
47-182 3.12e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.64  E-value: 3.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329  47 DGIWTPPLAVSFcktSRNSQLFAVSDEDGHVSLFNSsskkfassathqenTEKARFRDWIAHYNAIFDISWIKGDSCLLT 126
Cdd:COG2319   285 TGHSGGVNSVAF---SPDGKLLASGSDDGTVRLWDL--------------ATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039015329 127 ASGDQTIKVWDVEENKCTGVLIGHTGTVKSMCSHPtNSDLLVSGSRDGCFALWDLR 182
Cdd:COG2319   348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 327-399 1.91e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 1.91e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039015329 327 ISPDGEYVLSGSSDGNAYIWQVNKPQVdPIILKGHDFEVTAVDWSPSEiGKVATASDDFTVRLWNIENNICTN 399
Cdd:cd00200    17 FSPDGKLLATGSGDGTIKVWDLETGEL-LRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVR 87
WD40 pfam00400
WD domain, G-beta repeat;
141-180 1.02e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.02e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1039015329 141 NKCTGVLIGHTGTVKSMCSHPtNSDLLVSGSRDGCFALWD 180
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-180 2.31e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.31e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1039015329  142 KCTGVLIGHTGTVKSMCSHPtNSDLLVSGSRDGCFALWD 180
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 357-391 2.84e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 2.84e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1039015329  357 ILKGHDFEVTAVDWSPSEiGKVATASDDFTVRLWN 391
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 358-409 5.96e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 5.96e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039015329 358 LKGHDFEVTAVDWSPSEiGKVATASDDFTVRLWNIENNIC--TNANATASVSRV 409
Cdd:cd00200     5 LKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELlrTLKGHTGPVRDV 57
WD40 pfam00400
WD domain, G-beta repeat;
357-391 1.60e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.60e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1039015329 357 ILKGHDFEVTAVDWSPSEiGKVATASDDFTVRLWN 391
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 107-137 3.39e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.39e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1039015329  107 AHYNAIFDISWIKGDSCLLTASGDQTIKVWD 137
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 332-394 4.72e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.63  E-value: 4.72e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 332 EYVLSGSSDGNAYIWQV--NKPQV----DPI-ILKGHDFEVTAVDWSPSEIGKVATASDDFTVRLWNIEN 394
Cdd:PTZ00420   88 EILASGSEDLTIRVWEIphNDESVkeikDPQcILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIEN 157
PTZ00421 PTZ00421
coronin; Provisional
 121-257 6.97e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.19  E-value: 6.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 121 DSCLLTASGDQTIKVWDVEENKCTGV-------LIGHTGTVKSMCSHPTNSDLLVSGSRDGCFALWDL-RCKS----SSH 188
Cdd:PTZ00421   88 PQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVeRGKAveviKCH 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039015329 189 KEE------------FCINSTGMVKGAhLSPLSKRIRRRKAASSSITS--VLYVKDEITIATAGAPDS---ALKFWDIRK 251
Cdd:PTZ00421  168 SDQitslewnldgslLCTTSKDKKLNI-IDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIITLGCSKSqqrQIMLWDTRK 246


                  ....*.
gi 1039015329 252 LKAPFA 257
Cdd:PTZ00421  247 MASPYS 252
WD40 pfam00400
WD domain, G-beta repeat;
107-137 2.02e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 2.02e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1039015329 107 AHYNAIFDISWIKGDSCLLTASGDQTIKVWD 137
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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