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Conserved domains on  [gi|1039012797|gb|ANM62562|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD repeat BOP1/ERB1 family ribosome biogenesis protein( domain architecture ID 13743773)

WD repeat BOP1/ERB1 family ribosome biogenesis protein is a component of a complex that is required for maturation of ribosomal RNAs and formation of the 60S ribosome

CATH:  2.130.10.10
Gene Ontology:  GO:0042254|GO:0003676|GO:0043021|GO:0006364
PubMed:  10322433|30069656|21468892
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BOP1NT pfam08145
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 140-395 2.04e-156

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


:

Pssm-ID: 462371  Cd Length: 259  Bit Score: 453.53  E-value: 2.04e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 140 YEDEKHIGYDLTGKKITKKEKQDKLDSFLATIDDSKTWRKIYDEYNDEDVELTKEESKIVQRILKGEAPHADFDPYAPYV 219
Cdd:pfam08145   1 YDDYPHIGYDIDGKKIMKPAKGDALDKFLDSMDDPNAWRTVYDKLTGKDVVLTDEDLELIRRIQKGEFPDAGYDPYEPYV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 220 EWFKHDDAIHPLSSAPEPKRRFIPSKWEAKKVVKIVRAIRKGWIKFDKP-EEEPNVYLLWGD-DSTSDQKSKHLTYIPPP 297
Cdd:pfam08145  81 EWFTSEDEIHPLSNAPEPKRRFIPSKWEAKKVMKLVRAIRMGRIKPRKPkEEEPKFYDLWADeDETEEERRRRPDHIPAP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 298 KLKLPGHDESYNPSLEYIPTEEEKASYELMFEEDRPK-FIPTRFTSLRSIPAYENALKESFERCLDLYLCPRVRKKRINI 376
Cdd:pfam08145 161 KLPLPGHAESYNPPPEYLPTEEERKKWEEMDPEDRKLnFLPQKYDSLRLVPAYEKFIKERFERCLDLYLCPRVRKNRLNI 240

                         250
                  ....*....|....*....
gi 1039012797 377 DPESLKPKLPSRKDLRPYP 395
Cdd:pfam08145 241 DPESLLPKLPSPKDLRPFP 259
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 398-734 2.42e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 118.21  E-value: 2.42e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 398 CYLEYKGHTGAVTSISTDSSGEWIASGSTDGSVRMWEVETGRCLKVWQ----FDEAIMCVAWNPLsrlpVLAVAMGRDLF 473
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKghtgPVRDVAASADGTY----LASGSSDKTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 474 FLNTElgtdeeqeiTKERLHsgnipepdasvaaivtwlpdELYGgikirHFKSISSIDWHRKGDYLSTVMASGETRgvvL 553
Cdd:cd00200    77 LWDLE---------TGECVR--------------------TLTG-----HTSYVSSVAFSPDGRILSSSSRDKTIK---V 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 554 HQLSKQKTQRLPFKIRGLPVCTLFHPSLSYFFVATR-KDVRVYNLlKPGEATKKLETGLREISSMAIHPGGDNLIVGSKE 632
Cdd:cd00200   120 WDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQdGTIKLWDL-RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 633 GKMCWFDMDlSSKPYKTLKNHPKDITNVAVHRSYPLFASCSEDSTAYVFhgmvynDLNQNpliVPLEILRGHSSkgGVLD 712
Cdd:cd00200   199 GTIKLWDLS-TGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW------DLRTG---ECVQTLSGHTN--SVTS 266

                         330       340
                  ....*....|....*....|..
gi 1039012797 713 CKFHPRQPWLFTAGADSIIKLY 734
Cdd:cd00200   267 LAWSPDGKRLASGSADGTIRIW 288
 
Name Accession Description Interval E-value
BOP1NT pfam08145
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 140-395 2.04e-156

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 462371  Cd Length: 259  Bit Score: 453.53  E-value: 2.04e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 140 YEDEKHIGYDLTGKKITKKEKQDKLDSFLATIDDSKTWRKIYDEYNDEDVELTKEESKIVQRILKGEAPHADFDPYAPYV 219
Cdd:pfam08145   1 YDDYPHIGYDIDGKKIMKPAKGDALDKFLDSMDDPNAWRTVYDKLTGKDVVLTDEDLELIRRIQKGEFPDAGYDPYEPYV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 220 EWFKHDDAIHPLSSAPEPKRRFIPSKWEAKKVVKIVRAIRKGWIKFDKP-EEEPNVYLLWGD-DSTSDQKSKHLTYIPPP 297
Cdd:pfam08145  81 EWFTSEDEIHPLSNAPEPKRRFIPSKWEAKKVMKLVRAIRMGRIKPRKPkEEEPKFYDLWADeDETEEERRRRPDHIPAP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 298 KLKLPGHDESYNPSLEYIPTEEEKASYELMFEEDRPK-FIPTRFTSLRSIPAYENALKESFERCLDLYLCPRVRKKRINI 376
Cdd:pfam08145 161 KLPLPGHAESYNPPPEYLPTEEERKKWEEMDPEDRKLnFLPQKYDSLRLVPAYEKFIKERFERCLDLYLCPRVRKNRLNI 240

                         250
                  ....*....|....*....
gi 1039012797 377 DPESLKPKLPSRKDLRPYP 395
Cdd:pfam08145 241 DPESLLPKLPSPKDLRPFP 259
BOP1NT smart01035
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 140-395 1.74e-146

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 214986  Cd Length: 264  Bit Score: 428.28  E-value: 1.74e-146
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797  140 YEDEKHIGYDLTGKKITKKEKQDKLDSFLATIDDSKTWRKIYDEYNDEDVELTKEESKIVQRILKGEAPHADFDPYAPYV 219
Cdd:smart01035   1 YDDYPHIGYDIDGKKIMKPAKGDALDKFLDSIDDPNFWRTVYDKQTGKDVNLTDEELELIKRIQRGEIPDENYDPYEPYV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797  220 EWFKHDDAIHPLSSAPEPKRRFIPSKWEAKKVVKIVRAIRKGWIKFDKP-------EEEPNVYLLWGDDSTSDQKSKHLT 292
Cdd:smart01035  81 EWFTSEVEIMPLSNAPEPKRRFVPSKHEAKKIMKLVHAIRMGWIKPDKPpkekeeeEEYPKFYDLWADEDETETKFRIIM 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797  293 YIPPPKLKLPGHDESYNPSLEYIPTEEEKASYELMFEEDRPK-FIPTRFTSLRSIPAYENALKESFERCLDLYLCPRVRK 371
Cdd:smart01035 161 HIPAPKLPLPGHAESYNPPPEYLPTEEEKKEWEELEPEDRKLnFLPQKFDSLRKVPGYTNFIKERFERCLDLYLAPRQRR 240

                          250       260
                   ....*....|....*....|....
gi 1039012797  372 KRINIDPESLKPKLPSRKDLRPYP 395
Cdd:smart01035 241 NKLNIDPESLLPKLPSPKDLRPFP 264
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 398-734 2.42e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.21  E-value: 2.42e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 398 CYLEYKGHTGAVTSISTDSSGEWIASGSTDGSVRMWEVETGRCLKVWQ----FDEAIMCVAWNPLsrlpVLAVAMGRDLF 473
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKghtgPVRDVAASADGTY----LASGSSDKTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 474 FLNTElgtdeeqeiTKERLHsgnipepdasvaaivtwlpdELYGgikirHFKSISSIDWHRKGDYLSTVMASGETRgvvL 553
Cdd:cd00200    77 LWDLE---------TGECVR--------------------TLTG-----HTSYVSSVAFSPDGRILSSSSRDKTIK---V 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 554 HQLSKQKTQRLPFKIRGLPVCTLFHPSLSYFFVATR-KDVRVYNLlKPGEATKKLETGLREISSMAIHPGGDNLIVGSKE 632
Cdd:cd00200   120 WDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQdGTIKLWDL-RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 633 GKMCWFDMDlSSKPYKTLKNHPKDITNVAVHRSYPLFASCSEDSTAYVFhgmvynDLNQNpliVPLEILRGHSSkgGVLD 712
Cdd:cd00200   199 GTIKLWDLS-TGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW------DLRTG---ECVQTLSGHTN--SVTS 266

                         330       340
                  ....*....|....*....|..
gi 1039012797 713 CKFHPRQPWLFTAGADSIIKLY 734
Cdd:cd00200   267 LAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
398-734 3.73e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.70  E-value: 3.73e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 398 CYLEYKGHTGAVTSISTDSSGEWIASGSTDGSVRMWEVETGRCLKVWQ-FDEAIMCVAWNPLSRLpvLAVAmGRDlffln 476
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGKL--LASG-SDD----- 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 477 telGTdeeqeitkerlhsgnipepdasvaaIVTWlpdELYGGIKIR----HFKSISSIDWHRKGDYLSTvmaSGETRGVV 552
Cdd:COG2319   184 ---GT-------------------------VRLW---DLATGKLLRtltgHTGAVRSVAFSPDGKLLAS---GSADGTVR 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 553 LHQLSKQKTQRlPFKIRGLPVCTL-FHPSLSYFFVATR-KDVRVYNLlKPGEATKKLETGLREISSMAIHPGGDNLIVGS 630
Cdd:COG2319   230 LWDLATGKLLR-TLTGHSGSVRSVaFSPDGRLLASGSAdGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 631 KEGKMCWFDMDlSSKPYKTLKNHPKDITNVAVHRSYPLFASCSEDSTAYVFhgmvynDLNQNPLivpLEILRGHSskGGV 710
Cdd:COG2319   308 DDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW------DLATGEL---LRTLTGHT--GAV 375

                         330       340
                  ....*....|....*....|....
gi 1039012797 711 LDCKFHPRQPWLFTAGADSIIKLY 734
Cdd:COG2319   376 TSVAFSPDGRTLASGSADGTVRLW 399
WD40 pfam00400
WD domain, G-beta repeat;
396-434 1.76e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 1.76e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1039012797 396 NSCYLEYKGHTGAVTSISTDSSGEWIASGSTDGSVRMWE 434
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 395-434 3.65e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 3.65e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039012797  395 PNSCYLEYKGHTGAVTSISTDSSGEWIASGSTDGSVRMWE 434
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
BOP1NT pfam08145
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 140-395 2.04e-156

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 462371  Cd Length: 259  Bit Score: 453.53  E-value: 2.04e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 140 YEDEKHIGYDLTGKKITKKEKQDKLDSFLATIDDSKTWRKIYDEYNDEDVELTKEESKIVQRILKGEAPHADFDPYAPYV 219
Cdd:pfam08145   1 YDDYPHIGYDIDGKKIMKPAKGDALDKFLDSMDDPNAWRTVYDKLTGKDVVLTDEDLELIRRIQKGEFPDAGYDPYEPYV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 220 EWFKHDDAIHPLSSAPEPKRRFIPSKWEAKKVVKIVRAIRKGWIKFDKP-EEEPNVYLLWGD-DSTSDQKSKHLTYIPPP 297
Cdd:pfam08145  81 EWFTSEDEIHPLSNAPEPKRRFIPSKWEAKKVMKLVRAIRMGRIKPRKPkEEEPKFYDLWADeDETEEERRRRPDHIPAP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 298 KLKLPGHDESYNPSLEYIPTEEEKASYELMFEEDRPK-FIPTRFTSLRSIPAYENALKESFERCLDLYLCPRVRKKRINI 376
Cdd:pfam08145 161 KLPLPGHAESYNPPPEYLPTEEERKKWEEMDPEDRKLnFLPQKYDSLRLVPAYEKFIKERFERCLDLYLCPRVRKNRLNI 240

                         250
                  ....*....|....*....
gi 1039012797 377 DPESLKPKLPSRKDLRPYP 395
Cdd:pfam08145 241 DPESLLPKLPSPKDLRPFP 259
BOP1NT smart01035
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 140-395 1.74e-146

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 214986  Cd Length: 264  Bit Score: 428.28  E-value: 1.74e-146
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797  140 YEDEKHIGYDLTGKKITKKEKQDKLDSFLATIDDSKTWRKIYDEYNDEDVELTKEESKIVQRILKGEAPHADFDPYAPYV 219
Cdd:smart01035   1 YDDYPHIGYDIDGKKIMKPAKGDALDKFLDSIDDPNFWRTVYDKQTGKDVNLTDEELELIKRIQRGEIPDENYDPYEPYV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797  220 EWFKHDDAIHPLSSAPEPKRRFIPSKWEAKKVVKIVRAIRKGWIKFDKP-------EEEPNVYLLWGDDSTSDQKSKHLT 292
Cdd:smart01035  81 EWFTSEVEIMPLSNAPEPKRRFVPSKHEAKKIMKLVHAIRMGWIKPDKPpkekeeeEEYPKFYDLWADEDETETKFRIIM 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797  293 YIPPPKLKLPGHDESYNPSLEYIPTEEEKASYELMFEEDRPK-FIPTRFTSLRSIPAYENALKESFERCLDLYLCPRVRK 371
Cdd:smart01035 161 HIPAPKLPLPGHAESYNPPPEYLPTEEEKKEWEELEPEDRKLnFLPQKFDSLRKVPGYTNFIKERFERCLDLYLAPRQRR 240

                          250       260
                   ....*....|....*....|....
gi 1039012797  372 KRINIDPESLKPKLPSRKDLRPYP 395
Cdd:smart01035 241 NKLNIDPESLLPKLPSPKDLRPFP 264
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 398-734 2.42e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.21  E-value: 2.42e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 398 CYLEYKGHTGAVTSISTDSSGEWIASGSTDGSVRMWEVETGRCLKVWQ----FDEAIMCVAWNPLsrlpVLAVAMGRDLF 473
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKghtgPVRDVAASADGTY----LASGSSDKTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 474 FLNTElgtdeeqeiTKERLHsgnipepdasvaaivtwlpdELYGgikirHFKSISSIDWHRKGDYLSTVMASGETRgvvL 553
Cdd:cd00200    77 LWDLE---------TGECVR--------------------TLTG-----HTSYVSSVAFSPDGRILSSSSRDKTIK---V 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 554 HQLSKQKTQRLPFKIRGLPVCTLFHPSLSYFFVATR-KDVRVYNLlKPGEATKKLETGLREISSMAIHPGGDNLIVGSKE 632
Cdd:cd00200   120 WDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQdGTIKLWDL-RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 633 GKMCWFDMDlSSKPYKTLKNHPKDITNVAVHRSYPLFASCSEDSTAYVFhgmvynDLNQNpliVPLEILRGHSSkgGVLD 712
Cdd:cd00200   199 GTIKLWDLS-TGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW------DLRTG---ECVQTLSGHTN--SVTS 266

                         330       340
                  ....*....|....*....|..
gi 1039012797 713 CKFHPRQPWLFTAGADSIIKLY 734
Cdd:cd00200   267 LAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
398-734 3.73e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.70  E-value: 3.73e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 398 CYLEYKGHTGAVTSISTDSSGEWIASGSTDGSVRMWEVETGRCLKVWQ-FDEAIMCVAWNPLSRLpvLAVAmGRDlffln 476
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGKL--LASG-SDD----- 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 477 telGTdeeqeitkerlhsgnipepdasvaaIVTWlpdELYGGIKIR----HFKSISSIDWHRKGDYLSTvmaSGETRGVV 552
Cdd:COG2319   184 ---GT-------------------------VRLW---DLATGKLLRtltgHTGAVRSVAFSPDGKLLAS---GSADGTVR 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 553 LHQLSKQKTQRlPFKIRGLPVCTL-FHPSLSYFFVATR-KDVRVYNLlKPGEATKKLETGLREISSMAIHPGGDNLIVGS 630
Cdd:COG2319   230 LWDLATGKLLR-TLTGHSGSVRSVaFSPDGRLLASGSAdGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 631 KEGKMCWFDMDlSSKPYKTLKNHPKDITNVAVHRSYPLFASCSEDSTAYVFhgmvynDLNQNPLivpLEILRGHSskGGV 710
Cdd:COG2319   308 DDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW------DLATGEL---LRTLTGHT--GAV 375

                         330       340
                  ....*....|....*....|....
gi 1039012797 711 LDCKFHPRQPWLFTAGADSIIKLY 734
Cdd:COG2319   376 TSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 395-681 2.78e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.57  E-value: 2.78e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 395 PNSCYLEYKGHTGAVTSISTDSSGEWIASGSTDGSVRMWEVETGRCLKVW-QFDEAIMCVAWNPLSRLpvlAVAMGRDlf 473
Cdd:cd00200    40 TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLtGHTSYVSSVAFSPDGRI---LSSSSRD-- 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 474 flntelGTDeeqeitkeRLHSGNIPEPDASVAAivtwlpdelyggikirHFKSISSIDWHRKGDYLSTVMASGETRgvvL 553
Cdd:cd00200   115 ------KTI--------KVWDVETGKCLTTLRG----------------HTDWVNSVAFSPDGTFVASSSQDGTIK---L 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 554 HQLSKQKTQRLpFKIRGLPVCTL-FHPSLSYFFVATR-KDVRVYNLLKpGEATKKLETGLREISSMAIHPGGDNLIVGSK 631
Cdd:cd00200   162 WDLRTGKCVAT-LTGHTGEVNSVaFSPDGEKLLSSSSdGTIKLWDLST-GKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039012797 632 EGKMCWFDMDlSSKPYKTLKNHPKDITNVAVHRSYPLFASCSEDSTAYVF 681
Cdd:cd00200   240 DGTIRVWDLR-TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
502-734 2.00e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 2.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 502 ASVAAIVTWLPDELYGGIKIRHFKSISSIDWHRKGDYLSTVMASGETRGVVLHQLSKQKTQRLPFKIRGLPVCTLFHPSL 581
Cdd:COG2319    10 AAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039012797 582 SYFFVATRKD--VRVYNLlKPGEATKKLETGLREISSMAIHPGGDNLIVGSKEGKMCWFDMDlSSKPYKTLKNHPKDITN 659
Cdd:COG2319    90 GRLLASASADgtVRLWDL-ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA-TGKLLRTLTGHSGAVTS 167

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039012797 660 VAVHRSYPLFASCSEDSTAYVFhgmvynDLNQNPLIvplEILRGHSskGGVLDCKFHPRQPWLFTAGADSIIKLY 734
Cdd:COG2319   168 VAFSPDGKLLASGSDDGTVRLW------DLATGKLL---RTLTGHT--GAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 pfam00400
WD domain, G-beta repeat;
396-434 1.76e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 1.76e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1039012797 396 NSCYLEYKGHTGAVTSISTDSSGEWIASGSTDGSVRMWE 434
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 395-434 3.65e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 3.65e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039012797  395 PNSCYLEYKGHTGAVTSISTDSSGEWIASGSTDGSVRMWE 434
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
398-437 4.75e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 4.75e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1039012797 398 CYLEYKGHTGAVTSISTDSSGEWIASGSTDGSVRMWEVET 437
Cdd:COG2319   364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 397-434 8.83e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 8.83e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1039012797 397 SCYLEYKGHTGAVTSISTDSSGEWIASGSTDGSVRMWE 434
Cdd:cd00200   252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 643-682 2.05e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 2.05e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039012797  643 SSKPYKTLKNHPKDITNVAVHRSYPLFASCSEDSTAYVFH 682
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 697-734 3.29e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 3.29e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1039012797  697 PLEILRGHSskGGVLDCKFHPRQPWLFTAGADSIIKLY 734
Cdd:smart00320   4 LLKTLKGHT--GPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
697-734 7.55e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 7.55e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1039012797 697 PLEILRGHSskGGVLDCKFHPRQPWLFTAGADSIIKLY 734
Cdd:pfam00400   3 LLKTLEGHT--GSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
644-681 1.52e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.52e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1039012797 644 SKPYKTLKNHPKDITNVAVHRSYPLFASCSEDSTAYVF 681
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 404-456 5.11e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 5.11e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039012797 404 GHTGAVTSISTDSSGEWIASGSTDGSVRMWEVETGRCLKVWQF-DEAIMCVAWN 456
Cdd:pfam12894  36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAgSDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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