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Conserved domains on  [gi|1039010061|gb|ANM60048|]
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HCO3- transporter family [Arabidopsis thaliana]

Protein Classification

anion exchanger family transporter( domain architecture ID 705853)

anion exchanger family transporter similar to human SLC4 proteins which function as bicarbonate transporters

Gene Ontology:  GO:0005452|GO:0022857|GO:0055085
SCOP:  4003612
TCDB:  2.A.31

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Band_3_cyto super family cl26877
Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion ...
10-470 4.11e-38

Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk).


The actual alignment was detected with superfamily member TIGR00834:

Pssm-ID: 452680 [Multi-domain]  Cd Length: 900  Bit Score: 149.53  E-value: 4.11e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061  10 INRFTRiagELFGMLIAVLFLQQTIKGMVSEFR-------IPKGEDSK----------------------LEKYQFEWLY 60
Cdd:TIGR00834 482 ISRFTQ---EIFSFLISLIFIYETFSKLIKIFQehplqvfYNTLFCVPpkpqgpsvsallekdcsklggtLGGNNCRFQP 558
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061  61 TNGLLGLIFTVGLVYTALKSRKARSWPYGTGCCRSFVADYGVPLMVVVWTALSFS-----TPS-KLPSGVprRLVSPlpw 134
Cdd:TIGR00834 559 NTALLSLVLMLGTFFLAMFLRKFKNSRYFPGKARRLIGDFGVPISILIMVLVDIFigdtyTQKlSVPSGL--KVTNP--- 633
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061 135 dsvSLTHWtVIKDMGKVSPGYI---FAAFIPALMIAGLYFFDHSVVSQLAQQKEFNLKNPSAYHYDILLLGFMVLICGML 211
Cdd:TIGR00834 634 ---SARGW-FIPPLGENRPFPWwmmFAAALPALLVFILIFMEQQITTLIVSKKERKLKKGSGFHLDLLLVVGMGGVAALF 709
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061 212 GLPpsngvlpqspmhtkslavfkrqlmrrKMVMTAKESIrqkatssqvyedmeqvfiemdksplaeTHttlINELQdlke 291
Cdd:TIGR00834 710 GLP--------------------------WLSAATVRSV---------------------------TH---ANALT---- 729
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061 292 aVMKKSDDDGDTGEESGfdpekhvdaylpvrVNEQRVSNLLQSLLVIGAVFALPVIKLIPTSLLWGYFAYMAIDSLPDNQ 371
Cdd:TIGR00834 730 -VMSKASAPGEKAQIQE--------------VREQRVTGLLVAVLVGLSILMEPILKRIPLAVLFGIFLYMGVTSLSGIQ 794
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061 372 FFERTVLLFVPPTRRFKVlegahaSFVEKVPHKSIAAFTLFQILYFGLCYGVTWIPvAGIMFPVLFFLLVAIRQYLLPKL 451
Cdd:TIGR00834 795 LFDRLLLLLMPPKYHPDV------PYVRRVKTWRMHLFTAIQILCLALLWVVKSTP-ASLAFPFVLILTVPLRRLLLPRL 867
                         490       500
                  ....*....|....*....|...
gi 1039010061 452 FKPAYLRELDAAE----YEEIPG 470
Cdd:TIGR00834 868 FTERELKCLDKEDakvtFDEEDG 890
 
Name Accession Description Interval E-value
ae TIGR00834
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein ...
10-470 4.11e-38

anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein members of the AE family are found only in animals.They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule. [Transport and binding proteins, Anions]


Pssm-ID: 273290 [Multi-domain]  Cd Length: 900  Bit Score: 149.53  E-value: 4.11e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061  10 INRFTRiagELFGMLIAVLFLQQTIKGMVSEFR-------IPKGEDSK----------------------LEKYQFEWLY 60
Cdd:TIGR00834 482 ISRFTQ---EIFSFLISLIFIYETFSKLIKIFQehplqvfYNTLFCVPpkpqgpsvsallekdcsklggtLGGNNCRFQP 558
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061  61 TNGLLGLIFTVGLVYTALKSRKARSWPYGTGCCRSFVADYGVPLMVVVWTALSFS-----TPS-KLPSGVprRLVSPlpw 134
Cdd:TIGR00834 559 NTALLSLVLMLGTFFLAMFLRKFKNSRYFPGKARRLIGDFGVPISILIMVLVDIFigdtyTQKlSVPSGL--KVTNP--- 633
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061 135 dsvSLTHWtVIKDMGKVSPGYI---FAAFIPALMIAGLYFFDHSVVSQLAQQKEFNLKNPSAYHYDILLLGFMVLICGML 211
Cdd:TIGR00834 634 ---SARGW-FIPPLGENRPFPWwmmFAAALPALLVFILIFMEQQITTLIVSKKERKLKKGSGFHLDLLLVVGMGGVAALF 709
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061 212 GLPpsngvlpqspmhtkslavfkrqlmrrKMVMTAKESIrqkatssqvyedmeqvfiemdksplaeTHttlINELQdlke 291
Cdd:TIGR00834 710 GLP--------------------------WLSAATVRSV---------------------------TH---ANALT---- 729
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061 292 aVMKKSDDDGDTGEESGfdpekhvdaylpvrVNEQRVSNLLQSLLVIGAVFALPVIKLIPTSLLWGYFAYMAIDSLPDNQ 371
Cdd:TIGR00834 730 -VMSKASAPGEKAQIQE--------------VREQRVTGLLVAVLVGLSILMEPILKRIPLAVLFGIFLYMGVTSLSGIQ 794
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061 372 FFERTVLLFVPPTRRFKVlegahaSFVEKVPHKSIAAFTLFQILYFGLCYGVTWIPvAGIMFPVLFFLLVAIRQYLLPKL 451
Cdd:TIGR00834 795 LFDRLLLLLMPPKYHPDV------PYVRRVKTWRMHLFTAIQILCLALLWVVKSTP-ASLAFPFVLILTVPLRRLLLPRL 867
                         490       500
                  ....*....|....*....|...
gi 1039010061 452 FKPAYLRELDAAE----YEEIPG 470
Cdd:TIGR00834 868 FTERELKCLDKEDakvtFDEEDG 890
HCO3_cotransp pfam00955
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
1-412 9.88e-35

HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.


Pssm-ID: 460009  Cd Length: 497  Bit Score: 136.89  E-value: 9.88e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061   1 MAIFNMAYIINRFTRIAGELFGMLIAVLFLQQTIKGMVSEFR-------------------------------------I 43
Cdd:pfam00955 128 LVAFDASFLVRYITRFTEEIFALLISLIFIYEAFKKLIKIFKkyplylnydctcvppssnnttnstlslstesssinwsS 207
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061  44 PKGEDSKLEKYQFEWLYTNG-------LLGLIFTVGLVYTALKSRKARSWPYGTGCCRSFVADYGVPLMVVVWTALSFST 116
Cdd:pfam00955 208 LLTNSECTESYGGTLVGSGCgyvpdtaLLSLILFLGTFWLAYFLKQFKNSPFFPTKVRRLISDFAVPIAILIMVLVDYFL 287
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061 117 P---SKLPsgVPRRLVSPLPWDSvslthWTVIKdMGKVSPGYIFAAFIPALMIAGLYFFDHSVVSQLAQQKEFNLKNPSA 193
Cdd:pfam00955 288 GvytPKLQ--VPSGFKPTRPDRG-----WIINP-FGKNPWWLILAAILPALLVTILIFMDQQITAVIVNRKENKLKKGSG 359
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061 194 YHYDILLLGFMVLICGMLGLPPSNGVLPQSPMHTKSLAVfkrqlmrrkmvmtakESirqkatssqvyedmeqvfiemdks 273
Cdd:pfam00955 360 YHLDLFVVAILNGICSLFGLPWMVAATVRSITHVNSLKV---------------ES------------------------ 400
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061 274 plaETHttlinelqdlkeavmkksdddgDTGEESGFdpekhvdaylpVRVNEQRVSNLLQSLLVIGAVFALPVIKLIPTS 353
Cdd:pfam00955 401 ---ECV----------------------APGEKPKI-----------LGVREQRVTGLLVFILIGLSVFMTPVLKLIPMP 444
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039010061 354 LLWGYFAYMAIDSLPDNQFFERTVLLFVPPTrrfkvlegAH--ASFVEKVPHKSIAAFTLF 412
Cdd:pfam00955 445 VLYGVFLYMGVTSLSGIQFFDRILLLFMPQK--------HQpdTHYLRHVPLRKVHLFTLI 497
 
Name Accession Description Interval E-value
ae TIGR00834
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein ...
10-470 4.11e-38

anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein members of the AE family are found only in animals.They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule. [Transport and binding proteins, Anions]


Pssm-ID: 273290 [Multi-domain]  Cd Length: 900  Bit Score: 149.53  E-value: 4.11e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061  10 INRFTRiagELFGMLIAVLFLQQTIKGMVSEFR-------IPKGEDSK----------------------LEKYQFEWLY 60
Cdd:TIGR00834 482 ISRFTQ---EIFSFLISLIFIYETFSKLIKIFQehplqvfYNTLFCVPpkpqgpsvsallekdcsklggtLGGNNCRFQP 558
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061  61 TNGLLGLIFTVGLVYTALKSRKARSWPYGTGCCRSFVADYGVPLMVVVWTALSFS-----TPS-KLPSGVprRLVSPlpw 134
Cdd:TIGR00834 559 NTALLSLVLMLGTFFLAMFLRKFKNSRYFPGKARRLIGDFGVPISILIMVLVDIFigdtyTQKlSVPSGL--KVTNP--- 633
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061 135 dsvSLTHWtVIKDMGKVSPGYI---FAAFIPALMIAGLYFFDHSVVSQLAQQKEFNLKNPSAYHYDILLLGFMVLICGML 211
Cdd:TIGR00834 634 ---SARGW-FIPPLGENRPFPWwmmFAAALPALLVFILIFMEQQITTLIVSKKERKLKKGSGFHLDLLLVVGMGGVAALF 709
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061 212 GLPpsngvlpqspmhtkslavfkrqlmrrKMVMTAKESIrqkatssqvyedmeqvfiemdksplaeTHttlINELQdlke 291
Cdd:TIGR00834 710 GLP--------------------------WLSAATVRSV---------------------------TH---ANALT---- 729
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061 292 aVMKKSDDDGDTGEESGfdpekhvdaylpvrVNEQRVSNLLQSLLVIGAVFALPVIKLIPTSLLWGYFAYMAIDSLPDNQ 371
Cdd:TIGR00834 730 -VMSKASAPGEKAQIQE--------------VREQRVTGLLVAVLVGLSILMEPILKRIPLAVLFGIFLYMGVTSLSGIQ 794
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061 372 FFERTVLLFVPPTRRFKVlegahaSFVEKVPHKSIAAFTLFQILYFGLCYGVTWIPvAGIMFPVLFFLLVAIRQYLLPKL 451
Cdd:TIGR00834 795 LFDRLLLLLMPPKYHPDV------PYVRRVKTWRMHLFTAIQILCLALLWVVKSTP-ASLAFPFVLILTVPLRRLLLPRL 867
                         490       500
                  ....*....|....*....|...
gi 1039010061 452 FKPAYLRELDAAE----YEEIPG 470
Cdd:TIGR00834 868 FTERELKCLDKEDakvtFDEEDG 890
HCO3_cotransp pfam00955
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
1-412 9.88e-35

HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.


Pssm-ID: 460009  Cd Length: 497  Bit Score: 136.89  E-value: 9.88e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061   1 MAIFNMAYIINRFTRIAGELFGMLIAVLFLQQTIKGMVSEFR-------------------------------------I 43
Cdd:pfam00955 128 LVAFDASFLVRYITRFTEEIFALLISLIFIYEAFKKLIKIFKkyplylnydctcvppssnnttnstlslstesssinwsS 207
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061  44 PKGEDSKLEKYQFEWLYTNG-------LLGLIFTVGLVYTALKSRKARSWPYGTGCCRSFVADYGVPLMVVVWTALSFST 116
Cdd:pfam00955 208 LLTNSECTESYGGTLVGSGCgyvpdtaLLSLILFLGTFWLAYFLKQFKNSPFFPTKVRRLISDFAVPIAILIMVLVDYFL 287
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061 117 P---SKLPsgVPRRLVSPLPWDSvslthWTVIKdMGKVSPGYIFAAFIPALMIAGLYFFDHSVVSQLAQQKEFNLKNPSA 193
Cdd:pfam00955 288 GvytPKLQ--VPSGFKPTRPDRG-----WIINP-FGKNPWWLILAAILPALLVTILIFMDQQITAVIVNRKENKLKKGSG 359
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061 194 YHYDILLLGFMVLICGMLGLPPSNGVLPQSPMHTKSLAVfkrqlmrrkmvmtakESirqkatssqvyedmeqvfiemdks 273
Cdd:pfam00955 360 YHLDLFVVAILNGICSLFGLPWMVAATVRSITHVNSLKV---------------ES------------------------ 400
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039010061 274 plaETHttlinelqdlkeavmkksdddgDTGEESGFdpekhvdaylpVRVNEQRVSNLLQSLLVIGAVFALPVIKLIPTS 353
Cdd:pfam00955 401 ---ECV----------------------APGEKPKI-----------LGVREQRVTGLLVFILIGLSVFMTPVLKLIPMP 444
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039010061 354 LLWGYFAYMAIDSLPDNQFFERTVLLFVPPTrrfkvlegAH--ASFVEKVPHKSIAAFTLF 412
Cdd:pfam00955 445 VLYGVFLYMGVTSLSGIQFFDRILLLFMPQK--------HQpdTHYLRHVPLRKVHLFTLI 497
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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