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Conserved domains on  [gi|972905324|gb|ALW83270|]
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wingless (wg), partial [Bembidarenas reicheellum]

Protein Classification

wnt family protein( domain architecture ID 1562737)

wnt family protein may function in development and differentiation

Gene Ontology:  GO:0016055|GO:0005102|GO:0005576
PubMed:  22952392|20477987|8167409
SCOP:  4005649|4007801

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Wnt super family cl38924
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 1-159 8.71e-53

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


The actual alignment was detected with superfamily member cd19333:

Pssm-ID: 393294  Cd Length: 311  Bit Score: 169.46  E-value: 8.71e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************anmigNSIHSNHAGPERgq***** 80
Cdd:cd19333  165 GSCTVKTCWMRLPTFRTVGDRLKDRFDGASRVAYGNNGNNRGSRRAKKFLL----------EPENPNHKPPTS------- 227

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERCA 159
Cdd:cd19333  228 -------------------KDLVYFEESPNFCEKNPKLGTLGTRGRECNATSIGLDGCDLMCCGRGYRTETEEVKERCN 287
 
Name Accession Description Interval E-value
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 1-159 8.71e-53

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 169.46  E-value: 8.71e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************anmigNSIHSNHAGPERgq***** 80
Cdd:cd19333  165 GSCTVKTCWMRLPTFRTVGDRLKDRFDGASRVAYGNNGNNRGSRRAKKFLL----------EPENPNHKPPTS------- 227

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERCA 159
Cdd:cd19333  228 -------------------KDLVYFEESPNFCEKNPKLGTLGTRGRECNATSIGLDGCDLMCCGRGYRTETEEVKERCN 287
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 1-158 2.23e-45

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 150.40  E-value: 2.23e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324    1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************anmignSIHSNHAGPERGQ***** 80
Cdd:pfam00110 170 GSCSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRRNKRGRLV-------------------PRNSRFKPPTKND----- 225

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972905324   81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:pfam00110 226 ---------------------LVYLEKSPDYCERNPKTGSLGTRGRECNKTSSGPDGCDLLCCGRGYNTRTVTVTERC 282
WNT1 smart00097
found in Wnt-1;
1-158 4.11e-44

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 147.08  E-value: 4.11e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324     1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************ANMIGNSIHSNHAGPErgq***** 80
Cdd:smart00097 167 GSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNK---------------APVPKNSTFKPPTETD-------- 223

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972905324    81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:smart00097 224 ---------------------LVYLESSPDFCEKNPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERC 280
 
Name Accession Description Interval E-value
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 1-159 8.71e-53

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 169.46  E-value: 8.71e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************anmigNSIHSNHAGPERgq***** 80
Cdd:cd19333  165 GSCTVKTCWMRLPTFRTVGDRLKDRFDGASRVAYGNNGNNRGSRRAKKFLL----------EPENPNHKPPTS------- 227

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERCA 159
Cdd:cd19333  228 -------------------KDLVYFEESPNFCEKNPKLGTLGTRGRECNATSIGLDGCDLMCCGRGYRTETEEVKERCN 287
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 1-158 2.23e-45

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 150.40  E-value: 2.23e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324    1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************anmignSIHSNHAGPERGQ***** 80
Cdd:pfam00110 170 GSCSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRRNKRGRLV-------------------PRNSRFKPPTKND----- 225

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972905324   81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:pfam00110 226 ---------------------LVYLEKSPDYCERNPKTGSLGTRGRECNKTSSGPDGCDLLCCGRGYNTRTVTVTERC 282
WNT1 smart00097
found in Wnt-1;
1-158 4.11e-44

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 147.08  E-value: 4.11e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324     1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************ANMIGNSIHSNHAGPErgq***** 80
Cdd:smart00097 167 GSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNK---------------APVPKNSTFKPPTETD-------- 223

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972905324    81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:smart00097 224 ---------------------LVYLESSPDFCEKNPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERC 280
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
 1-158 5.09e-41

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 139.28  E-value: 5.09e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSqr***************aNMIGNSihSNHAGPERGQ***** 80
Cdd:cd19338  174 GSCTLKTCWRKMPPFREVGDRLKERFDGAIKVKGSNDGK------------------SLIPEG--KTIKPPTKED----- 228

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:cd19338  229 ---------------------LVYLEESPDFCEPNKKTGSLGTRGRECNRTSMGVDGCDLLCCGRGYQTEVRVVEENC 285
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 1-158 1.65e-36

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 127.02  E-value: 1.65e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************anmigNSIHSNHagpergq***** 80
Cdd:cd13113  151 GSCTTKTCWRQLPSFREIGDYLKEKYDNAVKVKLNNNGSGLRLVPKRSRF-----------RSPTETD------------ 207

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:cd13113  208 ---------------------LVYLEESPDYCEPNPTLGSLGTAGRECNPTSPGPDSCELLCCGRGYRTETEIVTEKC 264
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
 1-159 5.86e-36

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 126.28  E-value: 5.86e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************anmigNSIHSNHAgpergq***** 80
Cdd:cd19336  172 GSCELKTCWRAMPTFREVGNILKEKFDGATEVQQKRIGSRPVLVPK---------------NPQFKPHT----------- 225

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERCA 159
Cdd:cd19336  226 ------------------DADLVYLDSSPDFCEPDPKTGSLGTHGRVCNKTSKAIDGCDLLCCGRGYVTRTEEVVERCS 286
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
 1-159 2.00e-33

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 119.66  E-value: 2.00e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************anmignsihSNHAGPERgq***** 80
Cdd:cd19337  177 GSCSLKTCWRQLAPFREVGDRLKDKYDGAVKVKLNRRGTLLRRRNSR------------------FNKPTKDD------- 231

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERCA 159
Cdd:cd19337  232 ---------------------LVYLDDSPDYCERNPKTGSLGTKGRECNKTSSGTDGCELLCCGRGYNTKKVEVVERCH 289
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
 1-158 2.56e-33

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 119.32  E-value: 2.56e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************anmignSIHSNHAGPERgq***** 80
Cdd:cd19339  171 GSCTTKTCWTTLPSFREIGDYLKKKYERARRVEPVRGRRRRRPTFLKL--------------KISRKYKKPRP------- 229

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:cd19339  230 -------------------RDLVYLEKSPNYCEKDPLTGSLGTVGRRCNRTSTGTDGCDLMCCGRGYNTHQYTKTWQC 288
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
 1-158 9.40e-32

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 115.44  E-value: 9.40e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************ANmignsihsnhagpergq***** 80
Cdd:cd19342  176 GSCELKTCWKAAPDFREVGDILKEKYDHATLVDQSNLNNGARRRRLTRRKRRRRPPKT---------------------- 233

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:cd19342  234 --------------------DLVYYERSPNFCEADPSLDSPGTRGRVCNKTSTGPDSCDSLCCGRGYNTVRQTRTERC 291
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
 1-158 2.01e-31

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 114.28  E-value: 2.01e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************ANMIGNSIHSNHagpergq***** 80
Cdd:cd19343  167 GSCSVKTCWKALPDLSEVASRLKRKYARAVEVVSRKVGSRRKLVP-----------KSLKVRPYTKDD------------ 223

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:cd19343  224 ---------------------LIYLTKSPDYCLPDEKLGSLGTRGRECNKTSVGSDSCDSMCCGRGYRTYTVEVVERC 280
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
 1-158 3.89e-30

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 110.94  E-value: 3.89e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************anMIGNSIHSNHAGPergq***** 80
Cdd:cd19335  172 GSCELKTCWWAQPDFRKIGDYLKDKYDSASEMVVERHRESRGWVET------------LRPKYKLFKPPTE--------- 230

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:cd19335  231 -------------------RDLIYYEESPNFCEPNPETGSFGTRGRECNVTSHGIDGCDLLCCGRGYNTRTEKRTEKC 289
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
 1-158 3.39e-29

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 108.58  E-value: 3.39e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQr***************anmiGNSIHSNHAGPERgq***** 80
Cdd:cd19334  178 GSCTIRTCWRALAEFREVGDYLREKYDGAVQVTMNQSGTN--------------------LLAANKGHKKPTR------- 230

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:cd19334  231 -------------------SDLVYFESSPDYCVPNPETGSLGTAGRVCNKTSTGTDGCDIMCCGRGYDTTRVRRTTKC 289
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
 1-158 4.38e-29

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 108.09  E-value: 4.38e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNT--------GSQR***************anmignSIHSNhagpe 72
Cdd:cd19344  168 GSCEVKTCWKTMPSFEEVGDFLKQKYENSIQIATKKSkrrlrrreRRKRKV-------------------PISKD----- 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324  73 rgq**************************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEI 152
Cdd:cd19344  224 ----------------------------ELVYIHKSPNYCVRDPKKGILGTSGRECNRTSTGPDSCDLLCCGRGYNTQVV 275


                 ....*.
gi 972905324 153 VVVERC 158
Cdd:cd19344  276 RHVERC 281
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
 1-158 7.86e-23

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 91.58  E-value: 7.86e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************anmignsIHSNHAGPERGQ***** 80
Cdd:cd19348  177 GSCSLKTCWLQLADFRKVGDLLKEKYDSAAAMRINRKGKLE----------------------LVNSRFNPPTAED---- 230

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:cd19348  231 ---------------------LVYIDPSPDYCLRNETTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQVERC 287
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
 1-158 1.87e-22

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 90.89  E-value: 1.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************anmignSIHSNHAGPergq***** 80
Cdd:cd19347  177 GSCSLKTCWLQLADFRKVGDALKEKYDSAAAMKLNSRGKLV---------------------QVNSRFNPP--------- 226

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:cd19347  227 -----------------TTLDLVYIDPSPDYCVRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERC 287
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
 1-158 2.42e-21

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 87.73  E-value: 2.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGsqr***************anmiGNSIHSNHAGPERgq***** 80
Cdd:cd19355  164 GSCQLKTCWQVTPEFRTVGSLLKDRFYVATLIKPHNRN----------------------TGQLEPGHAPHRR------- 214

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:cd19355  215 ---------------RASINDLVYFEKSPDFCEREPRLDSAGTQGRICNKTSPGMDNCESLCCGRGHNILRQTRSERC 277
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
 1-158 4.41e-21

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 86.96  E-value: 4.41e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************anmignsiHSNHAGPERGq***** 80
Cdd:cd19341  161 GSCTVKTCWKQLAPFNEIGKILKRKYEKAVKVVSENNAATGGSQLRKGKSGS------------VKKKSRPRRK------ 222

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGieGTHGRFCNDTsigvDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:cd19341  223 --------------------DLVYLEKSPSFCRSTRYSP--GTKGRRCLKG----DNCDTLCCGRGYNTQSEVVVKPC 274
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
 1-158 9.57e-21

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 86.22  E-value: 9.57e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************anmignsihSNHAGPergq***** 80
Cdd:cd19350  176 GSCTTKTCWTTLPKFREIGYVLKEKYNAAVQVEVVRASRLRQPTFLKIKKR--------------RSYQKP--------- 232

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:cd19350  233 -----------------METDLVYIERSPNYCEEDAATGSVGTQGRLCNRTSPHTDGCDLMCCGRGYNTHQYTKVWQC 293
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
 1-158 1.92e-19

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 82.68  E-value: 1.92e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSqr***************anmiGNSI-HSNHAGPERGQ**** 79
Cdd:cd19345  178 GSCTVRTCWLAMADFRKTGDYLRKKYNGAIQVVMNQDGT---------------------GFTVaNKHFKKPTKND---- 232

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 972905324  80 **********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:cd19345  233 ----------------------LVYFENSPDYCVRDRDAGSLGTAGRVCNRTSRGMDGCEVMCCGRGYDTSRVGRMTKC 289
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
 1-158 2.54e-19

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 82.41  E-value: 2.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGAsrVMVSNTGSQR***************ANMIGNSihsnhagpergq***** 80
Cdd:cd19349  176 GSCTTKTCWTTLPKFRELGYILKDKYNEA--VHVEPVRASRNKRPTFLKIKKPLSYRKPMDTD----------------- 236

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:cd19349  237 ---------------------LVYIEKSPNYCEEDPVTGSVGTQGRMCNKTAQQNNGCDLMCCGRGYNTHQYSRVWQC 293
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
 1-158 1.16e-18

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 80.35  E-value: 1.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSqr***************ANmignsihSNHAGPERGQ***** 80
Cdd:cd19346  178 GSCTLRTCWLAMSDFRKTGDYLRKRYNGAVQVTMNQDGT-------------GFTVAN-------KNFRKATKTD----- 232

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:cd19346  233 ---------------------LVYFENSPDYCVMDKSAGSLGTAGRVCNKSSRGTDGCEVMCCGRGYDTTRVTRVTKC 289
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
 1-158 1.46e-16

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 74.54  E-value: 1.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVmvsntgsqr***************anmigNSIHSNHAGPERGQ***** 80
Cdd:cd19356  164 GSCQFKTCWHVTPEFRLVGALLREKFQRAIFI-----------------------------NSHNKNSGVFLPRLRPRRL 214

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGRGYLTKEIVVVERC 158
Cdd:cd19356  215 ARE------------------LVYFEKSPDFCERDPAVDSPGTQGRICNKTSPGMDGCGSLCCGRGHNILKQTRSERC 274
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
 1-158 6.58e-13

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 64.62  E-value: 6.58e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************ANMIGNSIHSNHAGPErgq***** 80
Cdd:cd19340  155 GSCSTQTCWMQLAPFREIGTDLKRKYDRAVRVDYENGGLRE---------------TNGSRAIKLLNIKKND-------- 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCN-DTSIGVDGCDLMCCGR-----GYLTKEIVV 154
Cdd:cd19340  212 ---------------------LVYLEKSPNYCRANVTLGWPGTLGRQCSrDKKESVSRWERKSCRRlcracGLKVRKKVV 270


                 ....*.
gi 972905324 155 VE--RC 158
Cdd:cd19340  271 EVtsSC 276
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 1-158 2.72e-12

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 62.61  E-value: 2.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVM-VSNTGSQR***************anmiGNSIHSNHAgpergq**** 79
Cdd:cd19354  158 GSCAVRTCWKQLSPFHETGRLLKLKYENAVKVHsVTNDATGETELWSPERH----------GHTLKGHSP---------- 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324  80 **********************LVYLE*SPGFCEknPKLGIEGTHGRFCN-DTSigvdgCDLMCCGRGYLTKEIVVVERC 158
Cdd:cd19354  218 ------------------RSTDLVYLEDSPSFCR--PSKYSPGTAGRTCSrETN-----CDSLCCGRGYNTQSRLVTFSC 272
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
 1-145 2.09e-08

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 51.83  E-value: 2.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGSQR***************anmiGNSIHSNHAGPErgq***** 80
Cdd:cd19351  157 GSCSIQTCWLQLADFREIGNYLKVKHDQALKLEMDKRRMRA-------------------GNSADNRGAIAE-------- 209

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFCNDTSIGVDGCDLMCCGR 145
Cdd:cd19351  210 ------------AFGSVAETELIYLEDSPDYCTKNASLGLQGTEGRECLQSGKNLSQWERRSCRR 262
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
 1-158 1.14e-07

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 49.65  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVmvsntGSQr***************anmignsihSNHAGPERGq***** 80
Cdd:cd19353  159 GSCTVRTCWRQLSPFHEIGKQLKQKYETSLKV-----GST-------------------------TNEATGEGD------ 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324  81 *********************LVYLE*SPGFC---EKNPklgieGTHGRFCNDTSigvdGCDLMCCGRGYLTKEIVVVER 157
Cdd:cd19353  203 -ISPPKKSGAGHSDQIPRTTDLVYIDDSPSFClmsRFSP-----GTSGRRCYKDK----NCESICCGRGHNTQSRVVTRP 272


                 .
gi 972905324 158 C 158
Cdd:cd19353  273 C 273
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
 1-128 1.44e-07

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 49.25  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972905324   1 GSCTVKTCWMRLPSFRVIGDNLKDRFDGASRVMVSNTGsqr***************anmiGNSIHSNHAGPErgq***** 80
Cdd:cd19352  158 GSCTTQTCWLQLPEFREVGNYLKEKYHRALKVDLLQGA----------------------GNSAASRGAIAE-------- 207

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 972905324  81 *********************LVYLE*SPGFCEKNPKLGIEGTHGRFC 128
Cdd:cd19352  208 ------------TFRSISKKELVHLEDSPDYCLENKTLGLLGTEGREC 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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