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Conserved domains on  [gi|957949716|gb|ALQ33630|]
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minichromosome maintenance complex component 7 isoform 1, partial [Homo sapiens]

Protein Classification

DNA replication licensing factor MCM( domain architecture ID 12168656)

DNA replication licensing factor MCM (minichromosome maintenance protein MCM) is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MCM smart00350
minichromosome maintenance proteins;
145-641 0e+00

minichromosome maintenance proteins;


:

Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 732.14  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   145 KPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSggRLYLQT 224
Cdd:smart00350   1 KPSSIRELRADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGATLGPEIQSGRETEPTVCPPRECQSPTP--FSLNHE 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   225 RgSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILrTGFRQVVQGLLSE--TYLEAHR 302
Cdd:smart00350  79 R-STFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVP-YGFKLNTVKGLPVfaTYIEANH 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   303 IVK--MNKSEDDESGA----GELTREELRQIAE-EDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQS-PRGMKIRGN 374
Cdd:smart00350 157 VRKldYKRSFEDSSFSvqslSDEEEEEIRKLSKdPDIYERLARSLAPSIYGHEDIKKAILLLLFGGVHKNlPDGMKIRGD 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   375 INICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEAD 454
Cdd:smart00350 237 INILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKMDDSD 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   455 RTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLA 534
Cdd:smart00350 317 RTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELA 396
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   535 QHITYVHQHSR-QPPSQFE-PLDMKLMRRYIAMCREK-QPMVPESLADYITAAYVEMRREAWASKDAT--YTSARTLLAI 609
Cdd:smart00350 397 KHVVDLHRYSHpEEDEAFEpPLSQEKLRKYIAYAREKiKPKLSEEAADKLVKAYVDLRKEDSQTESRSsiPITVRQLESI 476
                          490       500       510
                   ....*....|....*....|....*....|..
gi 957949716   610 LRLSTALARLRMVDVVEKEDVNEAIRLMEMSK 641
Cdd:smart00350 477 IRLSEAHAKMRLSDVVEEADVEEAIRLLRESI 508
MCM_N pfam14551
MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.
10-103 1.43e-17

MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.


:

Pssm-ID: 464206 [Multi-domain]  Cd Length: 95  Bit Score: 78.10  E-value: 1.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   10 KEKVKKFLQEFYQDDelgKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDPELVDSICENARRYAKLFADAVQELLPQYK 89
Cdd:pfam14551   1 KRKFKDFLEEFREDG---DGEFKYRDQLREMIEREQRSLEVDLDDLREFDPDLAEALLENPYEYLPLFEEALKEVVKELS 77
                          90
                  ....*....|....
gi 957949716   90 EREVVNKDVLDVYI 103
Cdd:pfam14551  78 EDPDYAEEEKEFQV 91
 
Name Accession Description Interval E-value
MCM smart00350
minichromosome maintenance proteins;
145-641 0e+00

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 732.14  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   145 KPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSggRLYLQT 224
Cdd:smart00350   1 KPSSIRELRADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGATLGPEIQSGRETEPTVCPPRECQSPTP--FSLNHE 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   225 RgSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILrTGFRQVVQGLLSE--TYLEAHR 302
Cdd:smart00350  79 R-STFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVP-YGFKLNTVKGLPVfaTYIEANH 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   303 IVK--MNKSEDDESGA----GELTREELRQIAE-EDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQS-PRGMKIRGN 374
Cdd:smart00350 157 VRKldYKRSFEDSSFSvqslSDEEEEEIRKLSKdPDIYERLARSLAPSIYGHEDIKKAILLLLFGGVHKNlPDGMKIRGD 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   375 INICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEAD 454
Cdd:smart00350 237 INILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKMDDSD 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   455 RTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLA 534
Cdd:smart00350 317 RTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELA 396
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   535 QHITYVHQHSR-QPPSQFE-PLDMKLMRRYIAMCREK-QPMVPESLADYITAAYVEMRREAWASKDAT--YTSARTLLAI 609
Cdd:smart00350 397 KHVVDLHRYSHpEEDEAFEpPLSQEKLRKYIAYAREKiKPKLSEEAADKLVKAYVDLRKEDSQTESRSsiPITVRQLESI 476
                          490       500       510
                   ....*....|....*....|....*....|..
gi 957949716   610 LRLSTALARLRMVDVVEKEDVNEAIRLMEMSK 641
Cdd:smart00350 477 IRLSEAHAKMRLSDVVEEADVEEAIRLLRESI 508
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
335-640 0e+00

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 611.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 335 KLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGL 414
Cdd:cd17758    1 KLAASIAPEIYGHEDVKKALLLLLVGGVDKRGDGMKIRGDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 415 TAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGR 494
Cdd:cd17758   81 TAAVMKDPVTGEMTLEGGALVLADQGICCIDEFDKMDESDRTAIHEVMEQQTISIAKAGITTTLNARTSILAAANPAYGR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 495 YNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVP 574
Cdd:cd17758  161 YNPRRSPEQNINLPAALLSRFDLLFLILDKPDRDNDLRLAEHVTYVHQHNKQPDSDFEPLDPKLLRAYIALAKRKRPTVP 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 957949716 575 ESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 640
Cdd:cd17758  241 PALADYIVQAYVEMRQEAKRSKDFTFTTPRTLLAILRLSQALARLRLSDSVEIDDVEEALRLMEMS 306
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
10-638 0e+00

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 535.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716  10 KEKVKKFLqefyqddelgkKQFKYGNQLVRLAHR--EQVALYVDLDDVAEDDPELVDSICENARRYAKLFADAVQELLPq 87
Cdd:COG1241    6 VDKFEEFL-----------RRYKYRDEILELAQEypEKRSLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALREIDL- 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716  88 ykerEVVNKDVLDVYIehrlmmeqrsrdpgmvrspqnqypaelmrRFelyfqgpsSNKPRV--IREVRADSVGKLVTVRG 165
Cdd:COG1241   74 ----EPYDVSLGDAHV-----------------------------RI--------TNLPETvpIRDIRSDHIGKLISVEG 112
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 166 IVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQtnrsgGRLYLQTRGSRFIKFQEMKMQEHSDQVP 245
Cdd:COG1241  113 IVRKATEVKPKITEAAFECPRCGTETYVPQTGEKLQEPHECPGCGRQ-----GPFKLLPEKSEFIDAQKIRIQEPPEDLP 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 246 VGNIPRSITVLVEGENTRIAQPGDHVSVTGIflpiLRTGFRQVVQGLLS--ETYLEAHRIVKMNKSEDDEsgagELTREE 323
Cdd:COG1241  188 GGQQPQSIDVILEDDLVGEVRPGDRVTVTGI----LRIEQRTSGRGKSTifDLYLEANSIEVEEKEFEEI----EITEED 259
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 324 LRQIAE----EDFYEKLAASIAPEIYGHEDVKKALLLllvggvdQ--------SPRGMKIRGNINICLMGDPGVAKSQLL 391
Cdd:COG1241  260 EEKIKElskdPDIYEKIIASIAPSIYGYEEIKEAIAL-------QlfggvpkvLPDGSRIRGDIHILLVGDPGTAKSQLL 332
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 392 SYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVS-GELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIA 470
Cdd:COG1241  333 RYAARLAPRGVYTSGKGSTAAGLTAAAVRDDFGtGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIA 412
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 471 KAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQ 550
Cdd:COG1241  413 KAGIVATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHILKVHRAGELLEQE 492
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 551 FE--------PLDMKLMRRYIAMCREK-QPMVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRM 621
Cdd:COG1241  493 IEeeteevkpEIDPDLLRKYIAYARRNvFPVLTEEAKDLIEDFYVDMRKKGEDEDSPVPITARQLEALIRLAEASARMRL 572
                        650
                 ....*....|....*..
gi 957949716 622 VDVVEKEDVNEAIRLME 638
Cdd:COG1241  573 SDTVTEEDAERAIRLVD 589
minchrom_main_MCM NF040949
minichromosome maintenance protein MCM;
10-638 4.36e-176

minichromosome maintenance protein MCM;


Pssm-ID: 468880 [Multi-domain]  Cd Length: 681  Bit Score: 519.48  E-value: 4.36e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716  10 KEKVKKFLQEFYQDDElgkkQFKYGNQLVRLAHREQVALYVDLDDVAEDDPELVDSICENARRYAKLFADAVQELLpqyk 89
Cdd:NF040949   2 GEKFKEFIRTFRDSFG----NEKYKERIFEMIAMRKRSLVVDFNDLYMFDPELADLLIEKPDEVLPAASKALKEIV---- 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716  90 erevvnkdvldvyiehrlmmeqRSRDPGMVRSPQNQYPaelmrRFElyfqgpssNKPRV--IREVRADSVGKLVTVRGIV 167
Cdd:NF040949  74 ----------------------EEEDPEYAEEVAKFHV-----RFR--------NLPRTvpLRDLRSEYIGKLIAVEGIV 118
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 168 TRVSEVKPKMVVATYTCDQCGAETYQPiQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVG 247
Cdd:NF040949 119 TRTTPVKPRIVKAVFRCRDCGCEFEWP-EEEEESYEIVEPPTVCPVCGKPGSFRLLQEKSKFIDWQKIVVQERPEELPPG 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 248 NIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSeTYLEAHRIVKMNKsEDDESgagELTREELRQI 327
Cdd:NF040949 198 QLPRSIEVVLEDDLVDTARPGDRVTVTGILRIKPDSSLKKGSRPIFK-NYIEANHIEVSQK-ELEEV---EITEEDEEKI 272
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 328 AE----EDFYEKLAASIAPEIYGHEDVKKALLLLLVG-GVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQ 402
Cdd:NF040949 273 LElakdPWIREKIIASIAPSIYGHWEIKEAIALLLFGgVPKVLPDGTRIRGDIHVLIVGDPGTAKSQLLQYVARLAPRAV 352
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 403 YTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARC 482
Cdd:NF040949 353 YTSGKGSTAAGLTAAVVRDKLTGEYYLEAGALVLADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATLNARA 432
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 483 SILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSrqppSQFEP-LDMKLMRR 561
Cdd:NF040949 433 SVLAAGNPKFGRYDPNRSVAENIDLPPTILSRFDLIFVIRDKPNEERDRRLARHILDVHSGK----EKVKPeIDPDLLKK 508
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 562 YIAMCREK-QPMVPESLADYITAAYVEMRREAWASKD---ATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLM 637
Cdd:NF040949 509 YIAYARKYvRPKLTEEAKKLIEDFYVEMRKSSKSSEDpdsPIPITARQLEALIRLSEAHAKMRLKDEVTAEDAERAIRLM 588

                 .
gi 957949716 638 E 638
Cdd:NF040949 589 L 589
MCM pfam00493
MCM P-loop domain;
322-541 2.24e-132

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 389.97  E-value: 2.24e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716  322 EELRQIA-EEDFYEKLAASIAPEIYGHEDVKKALLLLLVG-GVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAP 399
Cdd:pfam00493   3 EEIKELAkRPDIYDKLADSIAPSIYGHEDVKKAILLQLFGgVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKIAP 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716  400 RSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLN 479
Cdd:pfam00493  83 RAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIVATLN 162
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 957949716  480 ARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVH 541
Cdd:pfam00493 163 ARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
137-640 2.19e-84

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 286.12  E-value: 2.19e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 137 YFQGPSSNKPRVIREVRADSvgkLVTVRGIVTRVSEVKPKMVVATYTC---DQCGAETYQPIQSPTFMPLIMCPSQE--- 210
Cdd:PTZ00111 209 LMNKPVSDCVGNLEPSMADS---LVQFSGTVVRQTWIVPEITMACFRCrgqKKIGLNDYQPCTCEHYEYVIQGEVNEpll 285
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 211 CQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIP-RSITVLVEGENTRI-------------------AQPGDH 270
Cdd:PTZ00111 286 CNECNSKYTFELNHNMCVYSTKKIVKLLQSNSSLNNPDKDgLDNSVDNSGLNGEIymkdnevinlnlyddlidsVKTGDR 365
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 271 VSVTGIF--LPIlRTGFRQVVQGLLSETYLEA-H-RIVKMNKSEDDESG------AGELTREELRQIAE----EDFYEKL 336
Cdd:PTZ00111 366 VTVVGILkvTPI-RTSTTRRTLKSLYTYFVNViHvKVINSTNANQPEKGlkylgnENDFSDLQVYKILElsrnPMIYRIL 444
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 337 AASIAPEIYGHEDVKK----------ALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTG 406
Cdd:PTZ00111 445 LDSFAPSIKARNNVKIgllcqlfsgnKNSSDFNKSPDACYKVDNFRGIINVLLCGDPGTAKSQLLHYTHLLSPRSIYTSG 524
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 407 RGSSGVGLTAAV-LRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSIL 485
Cdd:PTZ00111 525 KSSSSVGLTASIkFNESDNGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYEVMEQQTVTIAKAGIVATLKAETAIL 604
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 486 AAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHI-----------------TY-------VH 541
Cdd:PTZ00111 605 ASCNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIakdfllphmtgsgndedTYdrsntmhVE 684
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 542 QHSRQPPSQFEPLDMKLMRRYIAMCR-EKQPMVPESLADYITAAYVEMRREAWASKD----------------------- 597
Cdd:PTZ00111 685 DESLRSEKDYNKNDLDMLRMYIKFSKlHCFPKLSDEAKKVITREYVKMRQGNFQTSNldelehaqedddddlyyqssgtr 764
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|...
gi 957949716 598 ATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 640
Cdd:PTZ00111 765 MIYVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSS 807
MCM_N pfam14551
MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.
10-103 1.43e-17

MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.


Pssm-ID: 464206 [Multi-domain]  Cd Length: 95  Bit Score: 78.10  E-value: 1.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   10 KEKVKKFLQEFYQDDelgKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDPELVDSICENARRYAKLFADAVQELLPQYK 89
Cdd:pfam14551   1 KRKFKDFLEEFREDG---DGEFKYRDQLREMIEREQRSLEVDLDDLREFDPDLAEALLENPYEYLPLFEEALKEVVKELS 77
                          90
                  ....*....|....
gi 957949716   90 EREVVNKDVLDVYI 103
Cdd:pfam14551  78 EDPDYAEEEKEFQV 91
 
Name Accession Description Interval E-value
MCM smart00350
minichromosome maintenance proteins;
145-641 0e+00

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 732.14  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   145 KPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSggRLYLQT 224
Cdd:smart00350   1 KPSSIRELRADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGATLGPEIQSGRETEPTVCPPRECQSPTP--FSLNHE 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   225 RgSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILrTGFRQVVQGLLSE--TYLEAHR 302
Cdd:smart00350  79 R-STFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVP-YGFKLNTVKGLPVfaTYIEANH 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   303 IVK--MNKSEDDESGA----GELTREELRQIAE-EDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQS-PRGMKIRGN 374
Cdd:smart00350 157 VRKldYKRSFEDSSFSvqslSDEEEEEIRKLSKdPDIYERLARSLAPSIYGHEDIKKAILLLLFGGVHKNlPDGMKIRGD 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   375 INICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEAD 454
Cdd:smart00350 237 INILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKMDDSD 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   455 RTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLA 534
Cdd:smart00350 317 RTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELA 396
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   535 QHITYVHQHSR-QPPSQFE-PLDMKLMRRYIAMCREK-QPMVPESLADYITAAYVEMRREAWASKDAT--YTSARTLLAI 609
Cdd:smart00350 397 KHVVDLHRYSHpEEDEAFEpPLSQEKLRKYIAYAREKiKPKLSEEAADKLVKAYVDLRKEDSQTESRSsiPITVRQLESI 476
                          490       500       510
                   ....*....|....*....|....*....|..
gi 957949716   610 LRLSTALARLRMVDVVEKEDVNEAIRLMEMSK 641
Cdd:smart00350 477 IRLSEAHAKMRLSDVVEEADVEEAIRLLRESI 508
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
335-640 0e+00

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 611.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 335 KLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGL 414
Cdd:cd17758    1 KLAASIAPEIYGHEDVKKALLLLLVGGVDKRGDGMKIRGDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 415 TAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGR 494
Cdd:cd17758   81 TAAVMKDPVTGEMTLEGGALVLADQGICCIDEFDKMDESDRTAIHEVMEQQTISIAKAGITTTLNARTSILAAANPAYGR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 495 YNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVP 574
Cdd:cd17758  161 YNPRRSPEQNINLPAALLSRFDLLFLILDKPDRDNDLRLAEHVTYVHQHNKQPDSDFEPLDPKLLRAYIALAKRKRPTVP 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 957949716 575 ESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 640
Cdd:cd17758  241 PALADYIVQAYVEMRQEAKRSKDFTFTTPRTLLAILRLSQALARLRLSDSVEIDDVEEALRLMEMS 306
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
10-638 0e+00

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 535.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716  10 KEKVKKFLqefyqddelgkKQFKYGNQLVRLAHR--EQVALYVDLDDVAEDDPELVDSICENARRYAKLFADAVQELLPq 87
Cdd:COG1241    6 VDKFEEFL-----------RRYKYRDEILELAQEypEKRSLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALREIDL- 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716  88 ykerEVVNKDVLDVYIehrlmmeqrsrdpgmvrspqnqypaelmrRFelyfqgpsSNKPRV--IREVRADSVGKLVTVRG 165
Cdd:COG1241   74 ----EPYDVSLGDAHV-----------------------------RI--------TNLPETvpIRDIRSDHIGKLISVEG 112
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 166 IVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQtnrsgGRLYLQTRGSRFIKFQEMKMQEHSDQVP 245
Cdd:COG1241  113 IVRKATEVKPKITEAAFECPRCGTETYVPQTGEKLQEPHECPGCGRQ-----GPFKLLPEKSEFIDAQKIRIQEPPEDLP 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 246 VGNIPRSITVLVEGENTRIAQPGDHVSVTGIflpiLRTGFRQVVQGLLS--ETYLEAHRIVKMNKSEDDEsgagELTREE 323
Cdd:COG1241  188 GGQQPQSIDVILEDDLVGEVRPGDRVTVTGI----LRIEQRTSGRGKSTifDLYLEANSIEVEEKEFEEI----EITEED 259
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 324 LRQIAE----EDFYEKLAASIAPEIYGHEDVKKALLLllvggvdQ--------SPRGMKIRGNINICLMGDPGVAKSQLL 391
Cdd:COG1241  260 EEKIKElskdPDIYEKIIASIAPSIYGYEEIKEAIAL-------QlfggvpkvLPDGSRIRGDIHILLVGDPGTAKSQLL 332
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 392 SYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVS-GELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIA 470
Cdd:COG1241  333 RYAARLAPRGVYTSGKGSTAAGLTAAAVRDDFGtGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIA 412
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 471 KAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQ 550
Cdd:COG1241  413 KAGIVATLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHILKVHRAGELLEQE 492
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 551 FE--------PLDMKLMRRYIAMCREK-QPMVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRM 621
Cdd:COG1241  493 IEeeteevkpEIDPDLLRKYIAYARRNvFPVLTEEAKDLIEDFYVDMRKKGEDEDSPVPITARQLEALIRLAEASARMRL 572
                        650
                 ....*....|....*..
gi 957949716 622 VDVVEKEDVNEAIRLME 638
Cdd:COG1241  573 SDTVTEEDAERAIRLVD 589
minchrom_main_MCM NF040949
minichromosome maintenance protein MCM;
10-638 4.36e-176

minichromosome maintenance protein MCM;


Pssm-ID: 468880 [Multi-domain]  Cd Length: 681  Bit Score: 519.48  E-value: 4.36e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716  10 KEKVKKFLQEFYQDDElgkkQFKYGNQLVRLAHREQVALYVDLDDVAEDDPELVDSICENARRYAKLFADAVQELLpqyk 89
Cdd:NF040949   2 GEKFKEFIRTFRDSFG----NEKYKERIFEMIAMRKRSLVVDFNDLYMFDPELADLLIEKPDEVLPAASKALKEIV---- 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716  90 erevvnkdvldvyiehrlmmeqRSRDPGMVRSPQNQYPaelmrRFElyfqgpssNKPRV--IREVRADSVGKLVTVRGIV 167
Cdd:NF040949  74 ----------------------EEEDPEYAEEVAKFHV-----RFR--------NLPRTvpLRDLRSEYIGKLIAVEGIV 118
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 168 TRVSEVKPKMVVATYTCDQCGAETYQPiQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVG 247
Cdd:NF040949 119 TRTTPVKPRIVKAVFRCRDCGCEFEWP-EEEEESYEIVEPPTVCPVCGKPGSFRLLQEKSKFIDWQKIVVQERPEELPPG 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 248 NIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSeTYLEAHRIVKMNKsEDDESgagELTREELRQI 327
Cdd:NF040949 198 QLPRSIEVVLEDDLVDTARPGDRVTVTGILRIKPDSSLKKGSRPIFK-NYIEANHIEVSQK-ELEEV---EITEEDEEKI 272
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 328 AE----EDFYEKLAASIAPEIYGHEDVKKALLLLLVG-GVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQ 402
Cdd:NF040949 273 LElakdPWIREKIIASIAPSIYGHWEIKEAIALLLFGgVPKVLPDGTRIRGDIHVLIVGDPGTAKSQLLQYVARLAPRAV 352
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 403 YTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARC 482
Cdd:NF040949 353 YTSGKGSTAAGLTAAVVRDKLTGEYYLEAGALVLADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATLNARA 432
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 483 SILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSrqppSQFEP-LDMKLMRR 561
Cdd:NF040949 433 SVLAAGNPKFGRYDPNRSVAENIDLPPTILSRFDLIFVIRDKPNEERDRRLARHILDVHSGK----EKVKPeIDPDLLKK 508
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 562 YIAMCREK-QPMVPESLADYITAAYVEMRREAWASKD---ATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLM 637
Cdd:NF040949 509 YIAYARKYvRPKLTEEAKKLIEDFYVEMRKSSKSSEDpdsPIPITARQLEALIRLSEAHAKMRLKDEVTAEDAERAIRLM 588

                 .
gi 957949716 638 E 638
Cdd:NF040949 589 L 589
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
335-640 4.74e-138

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 407.88  E-value: 4.74e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 335 KLAASIAPEIYGHEDVKKALLLLLVGGVDQS-PRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVG 413
Cdd:cd17706    1 ILADSIAPSIYGHEDVKKAVLLQLFGGVQKIlEDGTRIRGDIHILLVGDPGTAKSQILKYVLKIAPRGVYTSGKGSSGAG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 414 LTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYG 493
Cdd:cd17706   81 LTAAVVRDSETGEWYLEAGALVLADGGVCCIDEFDKMKELDRTALHEAMEQQTISIAKAGIVTTLNARCSILAAANPKGG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 494 RYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHS-----RQPPSQFEPLDMKLMRRYIAMCRE 568
Cdd:cd17706  161 RYNPKLSPIENINLPSPLLSRFDLIFVIRDDPDEERDEELAEHIIDLHRGSdpeeqVKPEEDGIPIDIELLRKYILYARQ 240
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 957949716 569 KQPMVPESLADYITAAYVEMRREAwASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 640
Cdd:cd17706  241 IHPKISEEAREKLVRWYVELRKES-ERRSTIPITARQLESVIRLAEAHAKMRLSEVVTEEDVEEAIRLVRHS 311
MCM pfam00493
MCM P-loop domain;
322-541 2.24e-132

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 389.97  E-value: 2.24e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716  322 EELRQIA-EEDFYEKLAASIAPEIYGHEDVKKALLLLLVG-GVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAP 399
Cdd:pfam00493   3 EEIKELAkRPDIYDKLADSIAPSIYGHEDVKKAILLQLFGgVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKIAP 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716  400 RSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLN 479
Cdd:pfam00493  83 RAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIVATLN 162
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 957949716  480 ARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVH 541
Cdd:pfam00493 163 ARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
335-637 5.82e-121

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 364.06  E-value: 5.82e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 335 KLAASIAPEIYGHEDVKKALLLLL--VGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGV 412
Cdd:cd17755    1 RLARSIAPSIYELEDVKKGILLQLfgGTRKDFTKTGGKYRGDINILLCGDPGTSKSQLLQYVHKISPRGVYTSGKGSSAV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 413 GLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAY 492
Cdd:cd17755   81 GLTAYVTRDPDTKQLVLESGALVLSDGGICCIDEFDKMSDSTRSVLHEVMEQQTLSIAKAGIITTLNARTSILASANPIG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 493 GRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREK-QP 571
Cdd:cd17755  161 SRYNPKLTVVENIDLPPTLLSRFDLIYLVLDKVDEKYDRRLAKHLVSLYLEDTPEHIQDEVLDVEVLTDYISYAREHiHP 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 957949716 572 MVPESLADYITAAYVEMRReAWASKDATYTSA-RTLLAILRLSTALARLRMVDVVEKEDVNEAIRLM 637
Cdd:cd17755  241 KLSEEAAQELVQAYVDMRK-MGSDARKRITATpRQLESLIRLAEAHAKMRLSNVVEAEDVEEAVRLI 306
MCM5 cd17756
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ...
335-640 2.92e-120

DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350662 [Multi-domain]  Cd Length: 317  Bit Score: 362.47  E-value: 2.92e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 335 KLAASIAPEIYGHEDVKKALLLLLVGGVDQS-PRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVG 413
Cdd:cd17756    1 IISKSIAPSIYGNEDIKKAIACLLFGGSRKRlPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSGKGSSAAG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 414 LTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYG 493
Cdd:cd17756   81 LTASVMRDPSTREFYLEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRTSVLAAANPVFG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 494 RYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSR--QPPSQFEP-LDMKLMRRYIAMCREK- 569
Cdd:cd17756  161 RYDDLKTPGDNIDFQTTILSRFDMIFIVKDKHDEERDITIAKHVINIHASARkaSQSQENEGeIPISKLKRYIAYCRAKc 240
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 957949716 570 QPMVPESLADYITAAYVEMRREAWASKDATYTSA------RTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 640
Cdd:cd17756  241 APRLSEEAAEKLSNHYVTIRKDVRQNELESDNRSsipitvRQLEAIIRISESLAKMELSPIATEKHVEEAIRLFQVS 317
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
334-637 3.77e-118

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 356.76  E-value: 3.77e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 334 EKLAASIAPEIYGHEDVKKALLLLL-VGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGV 412
Cdd:cd17761    1 EKIISSIAPSIYGHEDVKEAIALQLfGGVPKVLPDGTRIRGDIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGKGSTAA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 413 GLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAY 492
Cdd:cd17761   81 GLTAAVVRDEGTGEWYLEAGALVLADKGIAVVDEIDKMRKEDRSALHEAMEQQTISIAKAGIVATLNARAAVLAAANPKF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 493 GRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRqpPSQFEP-LDMKLMRRYIAMCREK-Q 570
Cdd:cd17761  161 GRFDSYRPVAEQIDLPPTLLSRFDLIFVLKDTPNEEKDRRLANHILDTHSGGE--MREIKPeIDPDLLRKYIAYARKNvR 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 957949716 571 PMVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLM 637
Cdd:cd17761  239 PVLTEEAKQLIKDFYVEMRKSGQETPSPVPITARQLEALVRLSEASARMRLSQEVTLEDAERAIRIM 305
MCM2 cd17753
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ...
335-637 1.34e-116

DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350659 [Multi-domain]  Cd Length: 325  Bit Score: 353.29  E-value: 1.34e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 335 KLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGM-KIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVG 413
Cdd:cd17753    1 RIINSIAPSIYGHDDIKTAIALALFGGVAKNPGGKhRIRGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFTTGQGASAVG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 414 LTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYG 493
Cdd:cd17753   81 LTASVRKDPVTKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPIGG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 494 RYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHItyVHQHSRQPPS--------------------QFEP 553
Cdd:cd17753  161 RYNPTLTFAQNVNLTEPILSRFDILCVVRDTVDPEEDERLAKFV--VGSHVRSHPEndedregeeeknqrqrpketKVEP 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 554 LDMKLMRRYIAMCREK-QPMVPESLADYITAAYVEMRREAWASKDATYTsARTLLAILRLSTALARLRMVDVVEKEDVNE 632
Cdd:cd17753  239 IPQELLRKYIHYAREKvRPKLNQMDMDKVSRVYADLRKESMATGSLPIT-VRHLESIIRISEAHAKMHLREYVSEEDVDM 317

                 ....*
gi 957949716 633 AIRLM 637
Cdd:cd17753  318 AIRVM 322
MCM6 cd17757
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ...
335-640 1.37e-116

DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350663 [Multi-domain]  Cd Length: 307  Bit Score: 352.83  E-value: 1.37e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 335 KLAASIAPEIYGHEDVKKALLLLLVG-GVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVG 413
Cdd:cd17757    1 NLVRSIAPSIYGHEEVKKGILLMLLGgVHKITREGISLRGDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSAAG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 414 LTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYG 493
Cdd:cd17757   81 LTAAVVRDEETGDFVIEAGALMLADNGICCIDEFDKMDIKDQVAIHEAMEQQTISITKAGIQATLNARTSILAAANPVGG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 494 RYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHItyVHQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMV 573
Cdd:cd17757  161 RYDRSKSLKQNINISAPIMSRFDLFFVLLDECNEVTDYAIASHI--VDLHSKREEAIEPPFTAEQLKRYIAYARTFKPKL 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 957949716 574 PESLADYITAAYVEMR-REAWASKDATY-TSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 640
Cdd:cd17757  239 TKEAKDELVEQYKELRqDDASGSTRSSYrITVRQLESLIRLSEAIARLHCSDEVTPEHVEEAARLLKKS 307
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
336-637 2.42e-112

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 341.37  E-value: 2.42e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 336 LAASIAPEIYGHEDVKKALLLLLVGGVDQS-PRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGL 414
Cdd:cd17754    2 LSKSLAPSIYGHEYIKKAILLMLLGGVEKNlENGSHLRGDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSSGVGL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 415 TAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGR 494
Cdd:cd17754   82 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHASLNARCSVLAAANPVYGR 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 495 YNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHsrqppsqfepldMKLMRRYIAMCREK-QPMV 573
Cdd:cd17754  162 YDVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRMHRY------------IKFLRKYIHYAKERiKPKL 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 957949716 574 PESLADYITAAYVEMRREAWASKDATYTS---ARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLM 637
Cdd:cd17754  230 TQEAAEYIAEEYADLRNDDNTKTDKARTSpitARTLETLIRLATAHAKARLSKTVDKVDAEVALNLL 296
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
137-640 2.19e-84

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 286.12  E-value: 2.19e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 137 YFQGPSSNKPRVIREVRADSvgkLVTVRGIVTRVSEVKPKMVVATYTC---DQCGAETYQPIQSPTFMPLIMCPSQE--- 210
Cdd:PTZ00111 209 LMNKPVSDCVGNLEPSMADS---LVQFSGTVVRQTWIVPEITMACFRCrgqKKIGLNDYQPCTCEHYEYVIQGEVNEpll 285
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 211 CQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIP-RSITVLVEGENTRI-------------------AQPGDH 270
Cdd:PTZ00111 286 CNECNSKYTFELNHNMCVYSTKKIVKLLQSNSSLNNPDKDgLDNSVDNSGLNGEIymkdnevinlnlyddlidsVKTGDR 365
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 271 VSVTGIF--LPIlRTGFRQVVQGLLSETYLEA-H-RIVKMNKSEDDESG------AGELTREELRQIAE----EDFYEKL 336
Cdd:PTZ00111 366 VTVVGILkvTPI-RTSTTRRTLKSLYTYFVNViHvKVINSTNANQPEKGlkylgnENDFSDLQVYKILElsrnPMIYRIL 444
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 337 AASIAPEIYGHEDVKK----------ALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTG 406
Cdd:PTZ00111 445 LDSFAPSIKARNNVKIgllcqlfsgnKNSSDFNKSPDACYKVDNFRGIINVLLCGDPGTAKSQLLHYTHLLSPRSIYTSG 524
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 407 RGSSGVGLTAAV-LRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSIL 485
Cdd:PTZ00111 525 KSSSSVGLTASIkFNESDNGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYEVMEQQTVTIAKAGIVATLKAETAIL 604
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 486 AAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHI-----------------TY-------VH 541
Cdd:PTZ00111 605 ASCNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIakdfllphmtgsgndedTYdrsntmhVE 684
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 542 QHSRQPPSQFEPLDMKLMRRYIAMCR-EKQPMVPESLADYITAAYVEMRREAWASKD----------------------- 597
Cdd:PTZ00111 685 DESLRSEKDYNKNDLDMLRMYIKFSKlHCFPKLSDEAKKVITREYVKMRQGNFQTSNldelehaqedddddlyyqssgtr 764
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|...
gi 957949716 598 ATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 640
Cdd:PTZ00111 765 MIYVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSS 807
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
336-640 1.74e-81

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 261.33  E-value: 1.74e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 336 LAASIAPEIYGHEDVKKALLLLLV---GGVDQSprGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGV 412
Cdd:cd17760    2 ILASLCPQVFGLYNVKLAVAMVLAggvQRIDAS--GTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 413 GLTAAVLRDSvsGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAy 492
Cdd:cd17760   80 GLTVTAVKDG--GEWNLEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 493 GRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITyvhqHSRQPPSQFEPL-DMKLMRRYIAMCREKQP 571
Cdd:cd17760  157 GQYDPNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFIL----ENKGEPSKSSKLwSMEKMRTYFCLIKNLRP 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 957949716 572 MVPESlADYITAAYVEMRREAwASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 640
Cdd:cd17760  233 VLSDE-ANAILLRYYQLQRQS-DCRNAARTTIRMLESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
336-640 3.30e-73

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 238.97  E-value: 3.30e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 336 LAASIAPEIYGHEDVKKALLLL----LVGGVDQSPRgMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSG 411
Cdd:cd17759    2 IVNSLCPAIYGHELVKAGLLLSlfggKQKYADDKNR-IPIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 412 VGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEaDRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPA 491
Cdd:cd17759   81 SGLTVTLTKDGRSGDFALEAGALVLGDQGICGIDEFDKMGS-QHQALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 492 YGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHityvhqhsrqppsqfepldMKLMRRYIAMCR-EKQ 570
Cdd:cd17759  160 GGHYNKGKTVSENLKMGPALLSRFDLVFILLDTPSEEHDHLLSEH-------------------HQLLRKYISYARqYVN 220
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 571 PMVPESLADYITAAYVEMRREAwASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 640
Cdd:cd17759  221 PVLSKDASEALQEFYLELRKQN-QLADSSPITTRQLESLIRLTEARARLELREEATKEDAEDVIEIMKES 289
MCM_OB pfam17207
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
149-280 8.35e-52

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 175.75  E-value: 8.35e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716  149 IREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTfmpliMCPSQECQtnrSGGRLYLQTRGSR 228
Cdd:pfam17207   2 IRDLRSEHIGKLVSVSGIVTRTSEVRPKLKKATFTCRKCGHTVGVKITEPT-----KCPNPECG---NKDPFKLVHEKSK 73
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 957949716  229 FIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPI 280
Cdd:pfam17207  74 FVDFQKIKIQESPEEVPAGELPRSLDVILDDDLVDRVKPGDRVTVTGIYRVV 125
MCM_lid pfam17855
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
558-641 3.34e-26

MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.


Pssm-ID: 465534 [Multi-domain]  Cd Length: 86  Bit Score: 102.62  E-value: 3.34e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716  558 LMRRYIAMCREK-QPMVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRL 636
Cdd:pfam17855   2 LLRKYIAYAREKiKPKLSEEAREKLVDAYVELRKESTGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEAIRL 81

                  ....*
gi 957949716  637 MEMSK 641
Cdd:pfam17855  82 LKESL 86
MCM_N pfam14551
MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.
10-103 1.43e-17

MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.


Pssm-ID: 464206 [Multi-domain]  Cd Length: 95  Bit Score: 78.10  E-value: 1.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716   10 KEKVKKFLQEFYQDDelgKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDPELVDSICENARRYAKLFADAVQELLPQYK 89
Cdd:pfam14551   1 KRKFKDFLEEFREDG---DGEFKYRDQLREMIEREQRSLEVDLDDLREFDPDLAEALLENPYEYLPLFEEALKEVVKELS 77
                          90
                  ....*....|....
gi 957949716   90 EREVVNKDVLDVYI 103
Cdd:pfam14551  78 EDPDYAEEEKEFQV 91
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
376-515 1.07e-05

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 45.75  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716  376 NICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSgvGLTAAVLRDSVS---GELTLEGGALVLADQ--GVCCIDEFDKm 450
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAALSNRPVFYVQLTR--DTTEEDLFGRRNidpGGASWVDGPLVRAARegEIAVLDEINR- 77
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 957949716  451 AEADRTAI-HEVMEQQTISIAKAGILTTLNARC-SILAAANPAYGRYNPrrsleqniqLPAALLSRF 515
Cdd:pfam07728  78 ANPDVLNSlLSLLDERRLLLPDGGELVKAAPDGfRLIATMNPLDRGLNE---------LSPALRSRF 135
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
444-630 8.71e-05

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 45.16  E-value: 8.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 444 IDEFDKmaeAD-RT--AIHEVMEQQTISIAKAGIltTLNARCSILAAANP--AYGRYnprrsleqniQLPAALLSRFDL- 517
Cdd:COG0714  100 ADEINR---APpKTqsALLEAMEERQVTIPGGTY--KLPEPFLVIATQNPieQEGTY----------PLPEAQLDRFLLk 164
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 957949716 518 LWLiqDRPDRDNDLRLaqhityVHQHSRQPPSQFEPLdmkLMRRYIAMCRE--KQPMVPESLADYITAAYVEMRREAWAS 595
Cdd:COG0714  165 LYI--GYPDAEEEREI------LRRHTGRHLAEVEPV---LSPEELLALQElvRQVHVSEAVLDYIVDLVRATREHPDLR 233
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 957949716 596 KDAtytSARTLLAILRLSTALARLRMVDVVEKEDV 630
Cdd:COG0714  234 KGP---SPRASIALLRAARALALLDGRDYVTPDDV 265
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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