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Conserved domains on  [gi|828178172|gb|AKK25348|]
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orthodenticle homeobox 2, partial [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 21)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

CATH:  1.10.10.60
Gene Ontology:  GO:0003677
PubMed:  26464018|1357790
SCOP:  4000291

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain super family cl47488
Homeodomain;
14-58 1.95e-14

Homeodomain;


The actual alignment was detected with superfamily member pfam00046:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 60.21  E-value: 1.95e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 828178172  14 RRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQ 58
Cdd:pfam00046  1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVK 45
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
14-58 1.95e-14

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 60.21  E-value: 1.95e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 828178172  14 RRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQ 58
Cdd:pfam00046  1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVK 45
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 14-58 9.10e-12

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 53.40  E-value: 9.10e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 828178172 14 RRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQ 58
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVK 45
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 13-58 9.34e-12

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 53.41  E-value: 9.34e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 828178172   13 QRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQ 58
Cdd:smart00389  1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVK 46
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
11-58 7.57e-08

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 45.51  E-value: 7.57e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 828178172  11 RKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQ 58
Cdd:COG5576   49 SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQ 96
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
14-58 1.95e-14

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 60.21  E-value: 1.95e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 828178172  14 RRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQ 58
Cdd:pfam00046  1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVK 45
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 14-58 9.10e-12

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 53.40  E-value: 9.10e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 828178172 14 RRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQ 58
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVK 45
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 13-58 9.34e-12

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 53.41  E-value: 9.34e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 828178172   13 QRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQ 58
Cdd:smart00389  1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVK 46
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
11-58 7.57e-08

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 45.51  E-value: 7.57e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 828178172  11 RKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQ 58
Cdd:COG5576   49 SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQ 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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