|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
31-460 |
2.37e-174 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 495.60 E-value: 2.37e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 31 CILVFFGLAVAYSLRVNLSVAIVAMTDRNASNPD-------------FPEFDWNESTKSYLLSSFFWGYVVTQIPGGYLS 97
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNnntstdkdtlpveAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 98 AIYGAKYMLFYGVLICSCLALLTPFCAvNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFG 177
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPLAA-RGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 178 TVVMLSVSGYIAsSSLGWPSTFYIPGCVGIVWSFVWLYLCsstpaqhptitpnerrfiessgqarrpsdagreeqprppt 257
Cdd:cd17318 160 TVIAMPLSGFLC-ESLGWPSIFYIFGGLGLLWCLLWFFLV---------------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 258 pwwriftsVPFLVLVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRGTvIP 337
Cdd:cd17318 199 --------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGI-LS 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 338 LGFSRKFFNTLGMWLPMLALIGLGYITEgeaNVRLAIGLLTAAVATNSATYLGFHVNHIDLSPNYAGTLMGITNCAANFM 417
Cdd:cd17318 270 TTTVRKLFTSIGFLGPGVFLIALGYLGS---NATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIA 346
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 761631414 418 SILAPLIVGLIVWDETNPAQWRIVFFFTAFVYFIGNLLFMLFG 460
Cdd:cd17318 347 GIISPLIVGAIVKNDQTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
18-469 |
6.85e-92 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 287.41 E-value: 6.85e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 18 GNTGPRFGVRHLQCILVFFGLAVAYSL------RVNLSVAIVAMTDRNASNPD-------------FPEFDWNESTKSYL 78
Cdd:TIGR00894 2 ENVFASTKLPYFCSFRLFLSFLLHICNviiiaqRICLSLTMVAMVNKENSTDLaclsaeneldnikNPNFKWSGALQGLI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 79 LSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLTPFCAvNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWA 158
Cdd:TIGR00894 82 LSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAA-GGGIALVVFCRVIQGLAQGSVSPATHKIIVKWA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 159 PAEERGRLVGYTYSGSQFGTVVMLSVSGYIASSSLGWPSTFYIPGCVGIVWSFVWLYLCSSTPAQHPTITPNERRFIESS 238
Cdd:TIGR00894 161 PPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 239 GQARRPSDagreeqpRPPTPWWRIFTSVPFLVLVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAMILL 318
Cdd:TIGR00894 241 LQGQKGST-------RQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLC 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 319 TCVFIWLSDTLKQRGTVIpLGFSRKFFNTLGMWLPMLALIGLGYITegeANVRLAIGLLTAAVATNSATYLGFHVNHIDL 398
Cdd:TIGR00894 314 SIFAGYLADFLKSSKTLS-LTAARKIFNGIGGLGPGIFAYALPYLS---AAFYLTIIILTLANAVSSGPLAGVLINSLDL 389
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 761631414 399 SPNYAGTLMGITNCAANFMSILAPLIVGLIVWDETNpAQWRIVFFFTAFVYFIGNLLFMLFGRTRVQPWNS 469
Cdd:TIGR00894 390 APRFLGFIKGITGLPGFIGGLIASTLAGNILSQDSK-NVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAK 459
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
32-460 |
1.25e-89 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 279.36 E-value: 1.25e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 32 ILVFFGLAVAYSLRVNLSVAIVAMTDRNASNPD---------------------FPEFDWNESTKSYLLSSFFWGYVVTQ 90
Cdd:cd17381 3 LLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSnnssnacpehssspsvehnetGKKYDWDAETQGWILGSFFYGYIITQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 91 IPGGYLSAIYGAKYMLFYGVLICSCLALLTPFCAVNG-GWtvVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGY 169
Cdd:cd17381 83 IPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGaGY--LIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 170 TYSGSQFGTVVMLSVSGYIAsSSLGWPSTFYIPGCVGIVWSFVWLYLCsstpaqhptitpnerrfiessgqarrpsdagr 249
Cdd:cd17381 161 SYAGAQLGTVVSLPLSGLIC-YYLDWTYVFYIFGAVGLLWFFLWIWLV-------------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 250 eeqprppTPWWRIftsvpflvlVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTL 329
Cdd:cd17381 208 -------MPLWAI---------VVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNL 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 330 KQRgTVIPLGFSRKFFNTLGMWLPMLALIGLGYITegeANVRLAIGLLTAAVATNSATYLGFHVNHIDLSPNYAGTLMGI 409
Cdd:cd17381 272 REK-QNFSTVCVRKIFTLIGMIGPAVFLLAAGFTG---CNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGI 347
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 761631414 410 TNCAANFMSILAPLIVGLIVWDETNPaQWRIVFFFTAFVYFIGNLLFMLFG 460
Cdd:cd17381 348 TNTFATIPGMVGPVIAKSLTHNNTVE-EWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
32-460 |
1.80e-88 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 275.20 E-value: 1.80e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 32 ILVFFGLAVAYSLRVNLSVAIVAMTDrnasnpdfpEFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVL 111
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAK---------EFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 112 ICSCLALLTPFCAvNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIASS 191
Cdd:cd17380 73 LWSLATLLTPLLA-YSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEY 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 192 SlGWPSTFYIPGCVGIVWSFVWLYLcsstpaqhptitpnerrfiessgqarrpsdagreeqprpptpwwriftSVPFLVL 271
Cdd:cd17380 152 Y-GWPSVFYFFGLLGLLWALVWLIY------------------------------------------------LPPVWAI 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 272 VLAHCANNWGFWTLLTEIPTFMKNVLGmDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRGtvIPLGFSRKFFNTLGMW 351
Cdd:cd17380 183 IVAHFCMNWGFYILLSWLPTYFHEVLV-PLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRG--WTVTSVRKLMQSIGFL 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 352 LPMLALIGLGYITegeaNVRLAIGLLTAAVATNSATYLGFHVNHIDLSPNYAGTLMGITNCAANFMSILAPLIVGLIVwd 431
Cdd:cd17380 260 GPALFLLLLSHTD----SFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYIL-- 333
|
410 420
....*....|....*....|....*....
gi 761631414 432 eTNPAQWRIVFFFTAFVYFIGNLLFMLFG 460
Cdd:cd17380 334 -EATGSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
32-460 |
9.55e-77 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 245.71 E-value: 9.55e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 32 ILVFFGLAVAYSLRVNLSVAIVAMTDRN------ASNPDFPEFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYM 105
Cdd:cd17382 2 IMAGLGFCISFGIRCNLGVAIVRMVNNFtdayggKVIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 106 LFYGVLICSCLALLTPFcAVNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVS 185
Cdd:cd17382 82 FGLAIFVTSTLNMLIPI-AARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 186 GYIAsSSLGWPSTFYIPGCVGIVWSFVWLYLCSstpaqhptitpnerrfiessgqarrpsdagreeqprpptPWWRIfts 265
Cdd:cd17382 161 GILV-QYVGWSSPFYVYGVFGIIWYMFWMLVSM---------------------------------------PVYAI--- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 266 vpflvlVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRG----TVIplgfs 341
Cdd:cd17382 198 ------IVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGilstTAV----- 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 342 RKFFNTLGMWLPMLALIGLGYITegeaNVRLAIGLLTAAVATNSATYLGFHVNHIDLSPNYAGTLMGITNCAANFMSILA 421
Cdd:cd17382 267 RKIFNCGGFGMEATFLLVVAFSH----SPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVC 342
|
410 420 430
....*....|....*....|....*....|....*....
gi 761631414 422 PLIVGLIVWDETnPAQWRIVFFFTAFVYFIGNLLFMLFG 460
Cdd:cd17382 343 PVIVGALTKHKT-REEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
26-463 |
1.90e-47 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 168.12 E-value: 1.90e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 26 VRHLQCILVFFGLAVAYSLRVNLSVAIVAMTDrnasnpdfpEFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYM 105
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQA---------DLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 106 LFYGVLICSCLALLTPFCavnGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVS 185
Cdd:COG2271 78 LAIGLLLWGLATLLFGFA---TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 186 GYIAsSSLGWPSTFYIPGCVGIVWSFvwlylcsstpaqhptitpnerrfiessgqarrpsdagreeqprpptpwwrifts 265
Cdd:COG2271 155 GWLL-AAFGWRAAFLILGLPGLLLAL------------------------------------------------------ 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 266 VPFLVLVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRGTVIPLgfsrkff 345
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLA------- 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 346 ntLGMWLPMLALIGLGYITegeaNVRLAIGLLTAAVATNSATYLGFHVNHIDLSP-NYAGTLMGITNCAANFMSILAPLI 424
Cdd:COG2271 253 --IGLLLAALALLLLALLP----SPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLL 326
|
410 420 430
....*....|....*....|....*....|....*....
gi 761631414 425 VGLIVwDETNpaqWRIVFFFTAFVYFIGNLLFMLFGRTR 463
Cdd:COG2271 327 VGYLL-DATG---YQAAFLLLAALALLAALLALLLLRET 361
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
27-458 |
9.08e-47 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 166.21 E-value: 9.08e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 27 RHLQCILVFFGLAVAYSLRVNLSVAIVAMTDrnasnpdfpEFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYML 106
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMK---------DLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 107 FYGVLICSCLALLTPFCavnGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSG 186
Cdd:cd17319 72 AVSMLLWSLFTALTGFA---TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 187 YIAsSSLGWPSTFYIPGCVGIVWSFVWlylcsstpaqhptitpnerrfiessgqarrpsdagreeqprpptpWWRIFTsv 266
Cdd:cd17319 149 WLL-LLFGWRWAFIIEGLLGLLLAVLW---------------------------------------------WFYLRQ-- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 267 pFLVLVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLkqrgtvipLGFSRKFFN 346
Cdd:cd17319 181 -VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRL--------LRGARRLVI 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 347 TLGMWLPMLALIGLGYITegeaNVRLAIGLLTAAVATNSATYLGFHVNHID-LSPNYAGTLMGITNCAANFMSILAPLIV 425
Cdd:cd17319 252 IIGLLLAAVGLLLAYLTT----SPVVAVILLSLAGFGIGAASPVFWSLPADlLPGEAAATAGGLINSGGNLGGFVAPLLI 327
|
410 420 430
....*....|....*....|....*....|...
gi 761631414 426 GLIVwDETNpaQWRIVFFFTAFVYFIGNLLFML 458
Cdd:cd17319 328 GYLV-DATG--SYTAAFLFLAAVALLAALLVLL 357
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
39-429 |
2.53e-38 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 144.40 E-value: 2.53e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 39 AVAYSLRVNLSVAIVAMTDrnasnpdfpEFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLAL 118
Cdd:TIGR00893 4 VINYLDRANLSFAAPMLQE---------DLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 119 LTPFCavnGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIAsSSLGWPST 198
Cdd:TIGR00893 75 LQAFA---GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWIL-IHFSWQWA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 199 FYIPGCVGIVWSFVWLYLCSSTPaQHPTITPNERRFIESsgQARRPSDAGREEQPRPPTPWWRIFTSVPFLVLVLAHCAN 278
Cdd:TIGR00893 151 FIIEGVLGIIWGVLWLKFIPDPP-QKAKWLTEEEKYIVV--GGLLAEQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 279 NWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRGtvIPLGFSRKFFNTLGMWLpMLALI 358
Cdd:TIGR00893 228 NIGLGFFLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRG--KSLVFARKTAIIAGLVL-SLLMF 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 761631414 359 GLGYITegeaNVRLAIGLLTAAVATNSATYLGFHVNHIDLSPNYAGTLMGITNCAANFMSILAPLIVGLIV 429
Cdd:TIGR00893 305 ATNYVN----IPYAALALVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIA 371
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
48-422 |
7.69e-33 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 127.92 E-value: 7.69e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 48 LSVAIVAMTDRNASNPDFP-----EFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLIcscLALLTPF 122
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPlllaeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLL---FALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 123 CAVNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIAsSSLGWPSTFYIP 202
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-SLFGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 203 GCVGIVWSFVWLYLCSSTPaqhptitpnerrfiessgqarRPSDAGREEQPRPPTPWWRIFTSVPFLVLVLAHCANNWGF 282
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPE---------------------SKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAF 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 283 WTLLTEIPTFMKnVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRGTVIPLGFSrkffntLGMWLPMLALIGLGY 362
Cdd:pfam07690 217 FGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLL------LILAALGLLLLSLTL 289
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 363 ITEGEANVRLAIGLLTAAVATNSATYLGFHVnhidlSPNYAGTLMGITNCAANFMSILAP 422
Cdd:pfam07690 290 SSLWLLLALLLLGFGFGLVFPALNALVSDLA-----PKEERGTASGLYNTAGSLGGALGP 344
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
25-466 |
9.78e-31 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 123.07 E-value: 9.78e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 25 GVRHLQCILVFFGLAVAYSLRVNLSVAIVAMTDrnasnpdfpEFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKY 104
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAE---------EFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 105 MLFYGVLICSCLALLTPFcAVNggWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSV 184
Cdd:COG2223 72 VLLIGLLLLGIGLLLLAL-AVS--YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 185 SGYIAsSSLGWPSTFYIPGCVGIVWSFVWLYLcsstpaqhptitpnerrfiessgqARRPSDAGREEQPRPPTPWWRIFT 264
Cdd:COG2223 149 APLLI-AAFGWRNAFLILGILLLVVAVLAWLF------------------------LRDPPAGAAAAAKASLRDQLEALR 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 265 SVPFLVLVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRGTVIplgfsrkf 344
Cdd:COG2223 204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLL-------- 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 345 fntLGMWLPMLALIGLGYITEGEANVRLAIGLLTAAV-ATNSATYlgFHVNHIdLSPNYAGTLMGITNCAANFMSILAPL 423
Cdd:COG2223 276 ---IVFALMALGLLLLALALGSLWLFLVLFLLLGLALgGGNGAVF--ALVPDI-FPTKNAGAVYGLVGAAGGLGGFLGPL 349
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 761631414 424 IVGLIVwDETNpaQWRIVFFFTAFVYFIGnLLFMLFGRTRVQP 466
Cdd:COG2223 350 LFGALL-DATG--SYTAAFLVFAVLALVA-LVLTLLLYRRPRR 388
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
34-456 |
3.65e-30 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 120.99 E-value: 3.65e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 34 VFFGLAVAYSLRVNLSVAIVAMTDrnasnpdfpEFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLIC 113
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQ---------SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLF 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 114 SCLALLTpfcAVNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIASS-S 192
Cdd:cd06174 72 ALGALLF---AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 193 LGWPSTFYIPGCVGIVWSFVWLylcsstpaqhptitpnerrFIESSGQARRPSDAGREEQPRPPTPWWRIFTSVPFLVLV 272
Cdd:cd06174 149 FGWRAVFLIAAALALLAAILLL-------------------LVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 273 LAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRGTVIPLGFsrkffntlGMWL 352
Cdd:cd06174 210 LAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGL--------LLMA 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 353 PMLALIGLGYITEGEANVRLAIGLLTAAVATNSATYLGFHVnhidlSPNYAGTLMGITNCAANFMSILAPLIVGLIVWDE 432
Cdd:cd06174 282 LGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELF-----PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT 356
|
410 420
....*....|....*....|....
gi 761631414 433 TNpaqWRIVFFFTAFVYFIGNLLF 456
Cdd:cd06174 357 FG---LTGAFLVLAVLLLLAAILL 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
67-421 |
8.76e-26 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 108.14 E-value: 8.76e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 67 EFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLtpfCAVNGGWTVVVVLRAVQGLCQGVI 146
Cdd:COG2814 39 DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL---CALAPSLWLLLAARFLQGLGAGAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 147 FPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIAsSSLGWPSTFYIPGCVGIV-WSFVWLYLCSSTPaqhp 225
Cdd:COG2814 116 FPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA-DLFGWRWVFLVNAVLALLaLLLLLRLLPESRP---- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 226 titpnerrfiessgqarrpsdagrEEQPRPPTPWWRIFTSVPFLVLVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNG 305
Cdd:COG2814 191 ------------------------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 306 PLSALPYFAMILLTCVFIWLSDTLKQRGTVIplgfsrkffntLGMWLPMLALIGLGYITEGEANV--RLAIGLLTAAVAT 383
Cdd:COG2814 247 LLLALFGLGGVLGALLAGRLADRFGRRRLLL-----------IGLLLLALGLLLLALAGSLWLLLlaLFLLGFGFGLLFP 315
|
330 340 350
....*....|....*....|....*....|....*...
gi 761631414 384 NSATYLGFHVnhidlSPNYAGTLMGITNCAANFMSILA 421
Cdd:COG2814 316 LLQALVAELA-----PPEARGRASGLYNSAFFLGGPLA 348
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
35-429 |
1.67e-25 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 107.85 E-value: 1.67e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 35 FFGLAVAYSLRVNLSVAIVAMTDrnasnpdfpEFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICS 114
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVE---------EIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 115 CLALLtpFCAVNGGWtVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIASSSLG 194
Cdd:TIGR00881 72 IVNLF--FGFSTSLW-VMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYS 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 195 WPSTFYIPGCVGIVWSFVWLYLCSSTPaQHPTITPNERRFIESS-------GQARRPSDAGREEQPRPPTPWWRIFtsVP 267
Cdd:TIGR00881 149 WHWVFIVPGIIAIIVSLICFLLLRDSP-QSCGLPPAEEMPNEEPdgdaekkEEELTKKQIFLQYVLLNKVLWYISL--GY 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 268 FLVLVLAHCANNWGfwtllteiPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLkQRGTVIPLGFSRkffnt 347
Cdd:TIGR00881 226 VFVYVVRTGILDWS--------PLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKL-FNGRRGPLAVFF----- 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 348 lgMWLPMLALIGLGYITEGEANVRLAIGLLTAAVATNSATYLGFHVNhiDLSP-NYAGTLMGITNCAANFMSILAPLIVG 426
Cdd:TIGR00881 292 --MALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVIAS--ELAPkKAAGTAAGFVGFFAYLGGILAGLPLG 367
|
...
gi 761631414 427 LIV 429
Cdd:TIGR00881 368 YLA 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
76-459 |
1.19e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 99.57 E-value: 1.19e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 76 SYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLIcscLALLTPFCAVNGGWTVVVVLRAVQGLCQGVIFPSTHTFLS 155
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLL---LAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 156 KWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIAsSSLGWPSTFYIPGCVGIVwSFVWLYLcsstpaqhptitpnerrFI 235
Cdd:cd17325 111 DIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLA-DALGYRAPFLVCAALALL-ALVLALL-----------------LL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 236 ESSgqaRRPSDAGREEQPRPPTPWWRIFTSVPFLVLVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAM 315
Cdd:cd17325 172 PEP---RPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLAS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 316 ILLTCVFIWLSDTlkqrgtviplgFSRKFFNTLGMWLPMLALIGLGYITEGEANVRLA--IGLLTAAVATNSATYLGfhv 393
Cdd:cd17325 249 ALSQPPAGKLSDR-----------IGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLalLGLGLGLVFPATLALLA--- 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 761631414 394 nhiDLSPNYA-GTLMGITNCAANFMSILAPLIVGLIVwdetNPAQWRIVFFFTAFVYFIGNLLFMLF 459
Cdd:cd17325 315 ---DIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLY----DAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
67-456 |
1.26e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 78.36 E-value: 1.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 67 EFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLIcscLALLTPFCAVNGGWTVVVVLRAVQGLCQGVI 146
Cdd:cd17324 28 DFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLL---FILGNLLAALAPSFALLLLARALAGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 147 FPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIAsSSLGWPSTFYIPGCVGIVWSFVWLYLCSSTPAQHPT 226
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLG-QLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 227 ITPNERRFiessgqarrpsdagreeqprpptpwWRIFTSVPFLVLVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGP 306
Cdd:cd17324 184 SLGLLSSL-------------------------LLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 307 LSALPYFAMILLTCVFIWLSDTLKQRGTVIPLGFSrkffntlgmwlpMLALIGLGYITEGEANVRLAIGLLTAAVATNSA 386
Cdd:cd17324 239 LLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLL------------AAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHS 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 387 TYLGFHVnhiDLSPNYAGTLMGITNCAANFMSILAPLIVGLiVWDEtnpAQWRIVFFFTAFVYFIGNLLF 456
Cdd:cd17324 307 ALQTRVL---RLAPEARGLASSLYLAAYNLGGALGAALGGL-VLDH---GGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
31-333 |
1.49e-14 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 75.36 E-value: 1.49e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 31 CILVFFGL--AVAYSLRVNLSVAIVA--MTDRNASNPDFpefdwnestkSYLLSSFFWGYVVTQIPGGYLSAIYGAKYML 106
Cdd:cd17327 5 FILPLLCIlyFLQYLDKSNISNAAVMgmKEDLKLVGNQY----------NWGNTVFYVGYIIFELPGNLLLQRFPPSKWL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 107 FYGVLICSCLALLTPFCAVNGGwtvVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVvmlsVSG 186
Cdd:cd17327 75 SVFIVLWGLLTLLTAAVKNFGG---LIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSI----FGG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 187 YIASSSL---------GWPSTFYIPGCVGIVWSFVWLYLCSSTPAQHPTITPNERRFIESSGQARRPSDagrEEQPRPPT 257
Cdd:cd17327 148 LLAYGVFkilgvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGK---GDQKFKWK 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 258 PWWRIFTSVPFLVLVLahcannwgFWTLLTEIPTFMKNVLGMDIKNNGP-------LSALPYFAMILLTCVFIWLSDTLK 330
Cdd:cd17327 225 QIKEAFKDPRTWLLFL--------FFFCSQITNNGISNFLPLILKSLGFyslqtnlLSVPIGALGAVSLLIAALLSDRFK 296
|
...
gi 761631414 331 QRG 333
Cdd:cd17327 297 KRG 299
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
67-216 |
1.61e-14 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 74.08 E-value: 1.61e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 67 EFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLtpfCAVNGGWTVVVVLRAVQGLCQGVI 146
Cdd:COG0477 43 DLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL---CGLAPSPELLIAARALQGIGAGGL 119
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 147 FPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIAsSSLGWPSTFYIPGCVGIVWSFVWLYL 216
Cdd:COG0477 120 MPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV-AALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
69-363 |
3.83e-13 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 70.85 E-value: 3.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 69 DWNESTKS--YLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLtpfCAVNGGWTVVVVLRAVQGLCQGVI 146
Cdd:TIGR00895 46 EWGLDPVQlgFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLL---CALATNVTQLLILRFLAGLGLGGL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 147 FPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTvvmlSVSGYIAS---SSLGWPSTFYIPGCVG-IVWSFVWLYLCSSTPA 222
Cdd:TIGR00895 123 MPNLNALVSEYAPKRFRGTAVGLMFCGYPIGA----AVGGFLAGwliPVFGWRSLFYVGGIAPlLLLLLLMRFLPESIDF 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 223 QHPTITPNERRFI-ESSGQARRPSDAGREEQPRPPTPWWRIF-------TSVPFLVLVLAHCANNWGFWTLLTEIPTFMK 294
Cdd:TIGR00895 199 LVSKRPETVRRIVnAIAPQMQAEAQSALPEQKSTQGTKRSVFkalfqgkTARITVLLWLLYFMLLVGVYFLTNWLPKLMV 278
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 761631414 295 NvLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQR---------GTVIPLGFSrKFFNTLGMwLPMLALIGLGYI 363
Cdd:TIGR00895 279 E-LGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRvtalllllgAVFAVLVGS-TLFSPTLL-LLLGAIAGFFVN 353
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
66-451 |
6.72e-13 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 69.94 E-value: 6.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 66 PEFDWNESTK--SYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLTPFCavnGGWTVVVVLRAVQGLCQ 143
Cdd:cd17316 27 AEFSLGLSLLqtGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLL---PTPILLLVLRFLQGIGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 144 GVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVS---GYIASSSLGWPSTFYIPGCVGIVwsfvwlylcsst 220
Cdd:cd17316 104 GGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVAsllIPLLSGDWGWRILFLIGALPALL------------ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 221 paqhptitpnerrfiessgqarrpsdagreeqprppTPWWRIFTsvpfLVLVLAHCANNWGFWTLLTEIPTFMKNVLGMD 300
Cdd:cd17316 172 ------------------------------------ALLLRRRT----LLLILLWFFISFGYYGLTTFLPTYLQTVLGLS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 301 IKNNGPLSALPYFAMILLTCVFIWLSDTlkqrgtviplgFSRKFFNTLGMWLPMLALIGLGYITEGEANVRLAIGLLTAA 380
Cdd:cd17316 212 PATSSLYLLLISLGALVGALIAGLLSDR-----------IGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSF 280
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 761631414 381 VATNSATYLGFHVNhiDLSP-NYAGTLMGITNCAANFMSILAPLIVGLIVWDETNPAQWRIVFFFTAFVYFI 451
Cdd:cd17316 281 FVGGVWGALYAYLA--ELFPtEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
66-336 |
2.99e-12 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 68.10 E-value: 2.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 66 PEFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLIcscLALLTPFCAVNGGWTVVVVLRAVQGLCQGV 145
Cdd:cd17371 27 AEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILL---FAVFTLLCGFAQNYWQLLILRALAGLGFGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 146 IFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGY---IASSSLGWPSTFYipgcVGIVWSFVWLYLcsstpa 222
Cdd:cd17371 104 EWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALlfpLLPPEIAWRVLFL----LGALPALLVLFI------ 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 223 qhptitpneRRFIESSGQARRPSDAGREEQPRPPTpwWRIF---TSVPFLVLVLAHCANNWGFWTLLTEIPTFMKNVLGM 299
Cdd:cd17371 174 ---------RRFVKEPPQWQAARAARRHFADRPSL--RELFsppLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGL 242
|
250 260 270
....*....|....*....|....*....|....*..
gi 761631414 300 DIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRGTVI 336
Cdd:cd17371 243 SFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFA 279
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
27-459 |
3.59e-11 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 64.60 E-value: 3.59e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 27 RHLQCILVFFGLAVAYSLRVNLSVAIVAMTDrnasnpdfpEFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYML 106
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVE---------EIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFM 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 107 FYGVLICSCLALLtpFCAVNGGWtVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSG 186
Cdd:cd17312 72 SAGLLLSALANIF--MGFSTSLW-FFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 187 YIAsSSLGWPSTFYIPGCVGIVWS-FVWLYLcsstpaqhptitpnerrfiessgqarrpsdagREeqpRPPTPWwrIFTS 265
Cdd:cd17312 149 SLA-SYYGWRAAFLVPGIVGLVVAiILFFFL--------------------------------RD---SPPYVW--VLSL 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 266 VPFLVLVLAHCANNWGfwtllteiPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRGTVIPLGFsrkff 345
Cdd:cd17312 191 AYAFVYIVRYACLDWG--------PLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVI----- 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 346 ntlgMWLPMLALIGLGYITEGEANVRLAIGLLTAAVATNSATYLGFHVNHIDLSPNYAGTLMGITNCAANFMSILAPLIV 425
Cdd:cd17312 258 ----YMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPL 333
|
410 420 430
....*....|....*....|....*....|....*
gi 761631414 426 GLIVWDetnpaqwriVFFFTAFVYFIG-NLLFMLF 459
Cdd:cd17312 334 GYIIDH---------YGWSTVFYFLISaALLSVLL 359
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
78-456 |
1.05e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 63.41 E-value: 1.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 78 LLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLtpfCAVNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKW 157
Cdd:cd17475 36 LLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALL---MALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRW 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 158 APAEERGRLVGYTYSGSQFGTVVMLSVSGYIAsSSLGWPSTFYIPGCVGI---VWSFVWLylcsSTPAQHPTITPNERRF 234
Cdd:cd17475 113 FPPRERGLAMGIRQTGVPLGGALAAALLPPLA-LHYGWRAAFVVAGLVSIlaaVLFWLFY----REPPAASAATESASTL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 235 IESSGQARRPSDAgreeqprpptpwWRIFTSVPFLVLVLahcannwgfWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFA 314
Cdd:cd17475 188 LRSLKEVLRNRDV------------WLIAIAGALLVAPQ---------FALLTFLLLFLHDHLGLSVVAAGALLAVAQLG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 315 MILLTCVFIWLSDTLKQRGTVIPLGFSrkffntlgMWLPMLALIGLGYITEGeaNVRLAIGLLTAAVatnSATYLGFHVN 394
Cdd:cd17475 247 GALGRIGLGRVSDRVFGGRRRPVLVIT--------AAIAAAALLVLSLLSPG--TPLWLLVLLLILL---GLFAIGWNGL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 761631414 395 HIDL-----SPNYAGTLMGITNCAANFMSILAPLIVGLIVWDETNpaqWRIVFFFTAFVYFIGNLLF 456
Cdd:cd17475 314 YLTLvaesaGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHS---YAPAWLALALLLVLAALLL 377
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
76-459 |
1.11e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 63.36 E-value: 1.11e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 76 SYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLtpfCAVNGGWTVVVVLRAVQGLCQGVIFPSTHTFLS 155
Cdd:cd17474 37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL---CGLSDSFALLLAGRALQGIGAAGLGPLALTLIG 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 156 KWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIASSSLGWPstFYIPGCVGIVWSFVWLYLCSSTPAQHPTITPNERRFI 235
Cdd:cd17474 114 DLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYP--FFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 236 EssgqarrpsdagreeqprpptpwwRIFTSVPFLVLVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAM 315
Cdd:cd17474 192 K------------------------KALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 316 ILLTCVFIWLSDTLKQRGTVIPLGFS--------RKFFNTLGMWLPMLALIGLGyitegeanvrlaIGLLTAAVATNSAT 387
Cdd:cd17474 248 ALGSLFVGRLLKKRFGARRILVIGLLlyalslllLGFVPSLALLLIAIVLFGLG------------LGLNLPLLTTLVTE 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 761631414 388 ylgfhvnhidLSPNYA-GTLMGITNCAANFMSILAPLIVGLIVwdetNPAQWRIVFFFTAFVYFIGNLLFMLF 459
Cdd:cd17474 316 ----------LAPEEErGTASSLYNFVRFLGQAVGPLLFGLLL----EIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
67-216 |
1.64e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 62.59 E-value: 1.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 67 EFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICsclALLTPFCAVNGGWTVVVVLRAVQGLCQGVI 146
Cdd:cd17325 229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS---AVALLLLPLATSFWLLLLLLALLGLGLGLV 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 147 FPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIAsSSLGWPSTFYIPGCVGIVWSFVWLYL 216
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLY-DAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
130-456 |
4.21e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 61.44 E-value: 4.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 130 TVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIAssSLGWPSTFYIPGCVGIVW 209
Cdd:cd17473 89 YALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA--EIGWRAPFLVYLLALPVL 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 210 SFVWLYLcsstpaqhptitpnerrfiessgqaRRPSDAgREEQPRPPTPWWRIFTSVPFLVLVLAHCANNWGFWTLLTEI 289
Cdd:cd17473 167 ILVLLFL-------------------------PEPARK-SKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQL 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 290 PTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRGTvIPLGFSRKFFNTLGMWL-PMLALIGLGYITEGea 368
Cdd:cd17473 221 PFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRL-LAIGFALMALGFLLLALaSGLWVVLLGAILAG-- 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 369 nvrLAIGLLTAAVATNSATYLGFHVNhidlspnyaGTLMGITNCAANFMSILAPLIVGLIVWDETNPAQWRIVFFFTAFV 448
Cdd:cd17473 298 ---LGFGLLLPTLNSWAMSLVPPELR---------GRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALV 365
|
....*...
gi 761631414 449 YFIGNLLF 456
Cdd:cd17473 366 LAIVLLLL 373
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
76-212 |
4.96e-10 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 57.66 E-value: 4.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 76 SYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLtpfCAVNGGWTVVVVLRAVQGLCQGVIFPSTHTFLS 155
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAM---FALSSNITVLIIARFLQGFGAAFALVAGAALIA 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 761631414 156 KWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIASSsLGWPSTFYIPGCVGIVWSFV 212
Cdd:TIGR00880 78 DIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQF-LGWRAPFLFLAILALAAFIL 133
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
77-208 |
8.08e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 57.63 E-value: 8.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 77 YLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLtpfCAVNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSK 156
Cdd:cd17328 38 LLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL---SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIAD 114
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 761631414 157 WAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIASSSLGWPSTFYIPGCVGIV 208
Cdd:cd17328 115 LFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVL 166
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
76-201 |
2.19e-08 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 55.65 E-value: 2.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 76 SYLLSSffwgyVVTQIPGGYLSAIYGAKYMLFYGVLIcscLALLTPFCAVNGGWTVVVVLRAVQGLCQGVIFPSTHTFLS 155
Cdd:cd17502 38 AYLLTS-----TAFQPIYGKLSDLFGRKWVLLIAIVI---FELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIA 109
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 761631414 156 KWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIAsSSLGWPSTFYI 201
Cdd:cd17502 110 DLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFT-DHLSWRWCFYI 154
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
67-466 |
6.76e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 54.49 E-value: 6.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 67 EFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYG-VLICSCLALLtpfcAVNGGWTVVVVLRAVQGLCQGV 145
Cdd:COG2807 47 DLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLAlLLLAAGLLLR----SLAPSVALLLAGTALIGAGIAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 146 IFPSTHTFLSKWAPaEERGRLVGYTYSGSQFGTVVMLSVSGYIASSsLGWPSTFYIPGCVGIVWSFVWLYLCSstpaqhp 225
Cdd:COG2807 123 GNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAA-LGWRGALAVWALLALLALLLWLPLLR------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 226 titpnerrfiessgqaRRPSDAGREEQPRPPTPWWRiftSVPFLVLVLAHCANNWGFWTLLTEIPTFMKNvLGMDIKNNG 305
Cdd:COG2807 194 ----------------RRPAAAAAAPAAASLRSLWR---SPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 306 PLSALPYFAMILLTCVFIWLSDTLKQRGTVIPLGFSRKFFNTLGMWL-----PMLALIGLGyitegeanvrLAIGLLTAA 380
Cdd:COG2807 254 LLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLapgslPWLWAVLLG----------LGQGGLFPL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 381 VATNSATYLGfhvnhidlSPNYAGTLMGITNCAANFMSILAPLIVGLIvWDETNPaqWRIVFFFTAFVYFIGNLLFMLFG 460
Cdd:COG2807 324 ALTLIGLRAR--------TPAEAAALSGMAQSVGYLLAALGPLLVGAL-HDATGS--WTAALLLLAALAVLMLVAGLLAG 392
|
....*.
gi 761631414 461 RTRVQP 466
Cdd:COG2807 393 RPYVED 398
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
78-221 |
1.03e-07 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 54.20 E-value: 1.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 78 LLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLTPFCAVNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKW 157
Cdd:pfam00083 51 IVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEI 130
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 158 APAEERGRLVGYTYSGSQFGTVVMlSVSGYI---ASSSLGWPSTFYipgcVGIVWS---FVWLYLCSSTP 221
Cdd:pfam00083 131 APKKLRGALGSLYQLAITFGILLA-YIFGLGlnkTSNSDGWRIPLG----LQLVPAlllIIGLLFLPESP 195
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
67-208 |
2.21e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 52.95 E-value: 2.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 67 EFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLIcSCLALLtpFCAVNGGWTVVVVLRAVQGLCQGVI 146
Cdd:cd17321 25 DLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLAL-FGLASL--LCALAPSLAFLIAARALQGIGAAAI 101
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 761631414 147 FPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIAsSSLGWPSTFYIPGCVGIV 208
Cdd:cd17321 102 MPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLL-ELFGWRWIFLINVPIGLV 162
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
80-222 |
3.29e-07 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 52.34 E-value: 3.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 80 SSFFWGYVVTQIPGGYLSAIYGAKYMLFYGvLICSCLALLTpFCAVNGGWtVVVVLRAVQGLCQGVIFPSTHTFLSKWap 159
Cdd:cd17343 45 SSQSLAYAISKFIGGVLSDQISARWLFSSG-LVLSGLTTVA-FSGSSSVW-VFSILWFLNGLAQGLGWPPCAKILRKW-- 119
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 761631414 160 aeergrlvgytYSGSQFGTV-VMLSVSGYIASS-----------SLGWPSTFYIPGCVGIVWSFVWLYLCSSTPA 222
Cdd:cd17343 120 -----------FSPSQFGTWwSVLSTSMNLAGSlgpilatllalSYGWRSTLSISGTVAVVMSVVCLLFIKNEPS 183
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
32-429 |
8.64e-07 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 51.09 E-value: 8.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 32 ILVFFGLAVAYSLRVNLSVAIVAMTDRNasnpdfpefDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVL 111
Cdd:cd17345 6 LGIFIGYAGYYLVRNNFSLAQPYLIEQY---------GLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 112 ICSCLALLTPFC-AVNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGT--VVMLSVSGYI 188
Cdd:cd17345 77 LSAIINILIGFVpSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGglVGPLAGLGLA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 189 ASSSLGWPSTFYIPGCVGIVWSFVWLYLCSSTPaQHPTITPNERRFIEssgqarRPSDAGREEQPRPPTPwWRIFTSvpf 268
Cdd:cd17345 157 IFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTP-ESEGLPPIEEYKGD------YPEEADGEEEEQELSA-WEIFVK--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 269 lvlvlaHCANNWGFWTL--------------LTEIPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDtlkqrgt 334
Cdd:cd17345 226 ------YVLKNKLLWYIaianvfvylvrygiLDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSD------- 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 335 viplgfsrKFFNTLGMWLPMLALIGLGYITEGEANVRLAIGLLTAAVATNSATY-----LGFHVnhIDLSP-NYAGTLMG 408
Cdd:cd17345 293 --------KLFKGRRAPTGIIFMILVIVALIVYWLAPNVLVDLIALIALGFLIYgpvmlIGLQA--LELVPkKAAGTAAG 362
|
410 420
....*....|....*....|..
gi 761631414 409 ITN-CAANFMSILAPLIVGLIV 429
Cdd:cd17345 363 LTGlFGYLGGSVLATALIGIIV 384
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
31-428 |
1.15e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 50.62 E-value: 1.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 31 CILVFFGLAVAYSLrvnLSVAIVAMTDrnasnpdfpEFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGV 110
Cdd:COG0738 13 IYLLFFLWGFATAL---WGPLIPALKD---------AFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 111 LICSCLALLTpfcAVNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLvgytySGSQ----FGTVVMLSVSG 186
Cdd:COG0738 81 LLMALGLLLF---ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRL-----NLLHaffsLGALLGPLLGG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 187 YIASSSLG--WPSTFYIPGCVGIVWSFVWLylcsstPAQHPTITPNERRFIESSGQARRPsdagreeqprpptpwWRIFT 264
Cdd:COG0738 153 LLILLGLSlsWHLPYLILAVLLLLLALLFL------RSKLPEIEEEEEEAAGSAASLKSL---------------LKNPR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 265 SVPFLVLVLAHCANNWGFWTLlteIPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRGTVipLGFSrkF 344
Cdd:COG0738 212 LLLGGLAIFLYVGAEGAIGDW---LPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLL--RLSA--L 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 345 FNTLGMWL------PMLALIGLgyitegeanvrLAIGLLTAAV--ATNSATylgfhvnhIDLSPNYAGTLMGITNCAANF 416
Cdd:COG0738 285 LAAVGLLLallapgPWLALIGL-----------ALVGLGLSLMfpTIFSLA--------LDGLGKRTAAAVSAVLIMGIV 345
|
410
....*....|..
gi 761631414 417 MSILAPLIVGLI 428
Cdd:COG0738 346 GGAIGPPLIGFL 357
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
21-216 |
2.09e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.92 E-value: 2.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 21 GPRFGVRHLQCILVFFGLAVAYSLRVNLSVAIVAMTDRNasnpdfpeFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIY 100
Cdd:cd06173 200 GLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEV--------LGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 101 GAKYMLFYGVLICsclALLTPFCAVNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVV 180
Cdd:cd06173 272 RRGRLLLIGALLL---GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPL 348
|
170 180 190
....*....|....*....|....*....|....*.
gi 761631414 181 MLSVSGYIAsSSLGWPSTFYIPGCVGIVWSFVWLYL 216
Cdd:cd06173 349 GALLAGLLA-DALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
66-339 |
3.42e-06 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 49.22 E-value: 3.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 66 PEFDWNESTKSYLLSS---FFWGYVVTQIPG---GYLSAIYGAKYMLFYGVLI---CSCLALLTPFCAVNGGWT--VVVV 134
Cdd:cd17367 27 PQFFPSGDPTVALLSTaavFAVGFLMRPIGGwlfGRLADRIGRRAALTLSVSLmaaGSLVIAVTPTYATIGIWApiILLL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 135 LRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTV-------VMLSVSGYIASSSLGWpstfYIPGCVGI 207
Cdd:cd17367 107 ARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLlalgvllVLQHTLGEDQMAAWGW----RIPFLLGG 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 208 VWSFVWLYLcsstpaqhptitpneRRFIESSgqarrPSDAGREEQPRPPTPWWRIFTSVP--FLVLVLAHCANNWGFWTL 285
Cdd:cd17367 183 VLAVVVLWL---------------RRGLEET-----ESFEAIAESNEASAGTLRELRRHPreLLLVVGLTAGGTLAFYTW 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 761631414 286 LTEIPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRGTVIPLG 339
Cdd:cd17367 243 TTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFG 296
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
94-210 |
3.56e-06 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 49.17 E-value: 3.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 94 GYLSAIYGAKYMLFYGVLICSCLALLTpfCAVNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSG 173
Cdd:cd17356 66 SFLSDRIGRKKSIQIGCVIYIIGAIIQ--VAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLA 143
|
90 100 110
....*....|....*....|....*....|....*..
gi 761631414 174 SQFGTVVMLSVSgyIASSSLGWPSTFYIPGCVGIVWS 210
Cdd:cd17356 144 ITIGILVAYCIN--YGTHKLDGSAQWRIPLGLQIVWG 178
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
78-245 |
4.43e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 48.74 E-value: 4.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 78 LLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLTPFCavnGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKW 157
Cdd:cd17489 36 VVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA---TSVALLLVLRLIHGIGWGAFTTAAATLVADI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 158 APAEERGRLVGYTYSGSQFGTVVMLSVSGYIASSslgwpSTFYIPGCVGIVWSFVWLYLCSSTPAQHPTITPNERRFIES 237
Cdd:cd17489 113 IPPSRRGEGIGYYGLATTLAMALGPALGLFLYQH-----LGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRA 187
|
....*...
gi 761631414 238 SGQARRPS 245
Cdd:cd17489 188 FRRLVEKK 195
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
85-214 |
4.92e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 48.75 E-value: 4.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 85 GYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLTPFCAVNGGWTVVVVLRAVQGLCQGViFPSTHTFLSKWAPAEERG 164
Cdd:cd17316 225 GALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGV-WGALYAYLAELFPTEVRA 303
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 761631414 165 RLVGYTYSGSQFGTVVMLSVSGYIASSSLGWPSTFYIPGCVGIVWSFVWL 214
Cdd:cd17316 304 TGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
104-459 |
1.55e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.20 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 104 YMLFYGVLICSCLALL--TPFCAVNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAP-AEERGRLVGYTYSGSQFGTVV 180
Cdd:COG2211 83 WILIGAIPLALSFVLLftAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 181 MLSVSGYI-----ASSSLGWPSTFYIPGCVGIVwSFVWLYLCSstpAQHPTITPNERRFIESsgqarrpsdagreeqprp 255
Cdd:COG2211 163 ASVLPPPLvaafgGDAALGYRLTALIFAVLGLL-AFLLTFFGT---KERPVPEEEKVSLKES------------------ 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 256 ptpWWRIFTSVPFLVLVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRGTV 335
Cdd:COG2211 221 ---LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAF 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 336 IP------LGFSRKFFNTLGMWLPMLALIGLGYITEGeanvrlAIGLLTAAVATNSATYlgfhvNHIDLSPNYAGTLMGI 409
Cdd:COG2211 298 IIglllaaLGLLLLFFLGPGNLWLLLVLAALAGIGLG------AILVLPWAMLADVVDY-----DEWKTGRRREGLYFGI 366
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 410 TNCAANFMSILAPLIVGLIVW------DETNPAQW----RIVFFFTAFVYFIGNLLFMLF 459
Cdd:COG2211 367 FTFAIKLGQALAGALAGLLLAlfgyvaGAAQSPSAltgiRLLFFLLPAVLLLLAALLLLF 426
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
67-216 |
4.91e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 45.26 E-value: 4.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 67 EFDWNESTKSYLLSSFFWGYVVTQIP-GGYLSAIYGAKYMLFYGVLICSCLALLTPFCAVNGgwtVVVVLRAVQGLCQGV 145
Cdd:cd17330 204 RFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVP---LLVLAAAILAFGTGI 280
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 761631414 146 IFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIASSSlgWPSTFYIPGCVGIVWSFVWLYL 216
Cdd:cd17330 281 VFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFL--GPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
94-208 |
7.45e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 44.87 E-value: 7.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 94 GYLSAIYGAKyMLFYGVLICSCLALLtpFCAVNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSG 173
Cdd:cd17503 52 GWLADRFGTR-RLFLTALALFTLGSL--LCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLV 128
|
90 100 110
....*....|....*....|....*....|....*
gi 761631414 174 SQFGTVVMLSVSGYIaSSSLGWPSTFYIPGCVGIV 208
Cdd:cd17503 129 ILLAPAIGPTLGGWL-TDNLSWRWIFYINLPIGIL 162
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
73-215 |
1.45e-04 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 44.25 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 73 STKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLTPFCAVNGGWTVVVVLRAVQGLCQGVIFPSTHT 152
Cdd:TIGR00879 71 SLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPM 150
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 761631414 153 FLSKWAPAEERGRLVGYTYSGSQFGTVV--MLSVSGYIASSSLGWPSTFY------IPGCVGIVW---SFVWLY 215
Cdd:TIGR00879 151 YLSEIAPKALRGALTSLYQLAITFGILVayGFGSGKVSLNNTLGWRIPLGlqlipaGLLFLGLFFlpeSPRWLV 224
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
32-224 |
1.57e-04 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 44.29 E-value: 1.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 32 ILVFFGLAVAYSLRVnLSVAIVAMTDRNASNP---DFPEFDWneSTKSYLLSSffwgyvVTQIP-GGYLSAIYGAKYMLF 107
Cdd:TIGR00711 1 LLLTIVLMLGTFMAV-LDSTIVNVAIPTIAGDlgsSLSQVQW--VITSYMLAN------AISIPlTGWLAKRFGTRRLFL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 108 YGVLicsCLALLTPFCAVNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGY 187
Cdd:TIGR00711 72 ISTF---AFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGW 148
|
170 180 190
....*....|....*....|....*....|....*...
gi 761631414 188 IaSSSLGWPSTFYIPGCVGI-VWSFVWLYLCSSTPAQH 224
Cdd:TIGR00711 149 I-IENYHWRWIFLINVPIGIiVVVVAFFILPRDKPAAS 185
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
271-485 |
1.79e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.56 E-value: 1.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 271 LVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRGTVIPLGFSRKFFNTLGM 350
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 351 WLPMLALIGLGyitegeanvRLAIGLLTAAVATNSATYLGFHVnhidlSPNYAGTLMGITNCAANFMSILAPLIVGLIVw 430
Cdd:pfam07690 81 FASSLWLLLVL---------RVLQGLGAGALFPAALALIADWF-----PPEERGRALGLVSAGFGLGAALGPLLGGLLA- 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 761631414 431 detNPAQWRIVFFFTAFVYFIGnLLFMLFGRTRVQPWNSRPTTRTPSPGGGGERD 485
Cdd:pfam07690 146 ---SLFGWRAAFLILAILSLLA-AVLLLLPRPPPESKRPKPAEEARLSLIVAWKA 196
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
67-458 |
2.25e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 43.33 E-value: 2.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 67 EFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLIcscLALLTPFCAVNGGWTVVVVLRAVQGLCQGVI 146
Cdd:cd17320 28 DLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLL---FILASLLCALASSIEQLLIARFLQGLGAAAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 147 FPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIAsSSLGWPSTFYIPGCVGIVwSFVWLYLCSSTPAQHPT 226
Cdd:cd17320 105 SVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLL-LFFGWRAIFVFLALLGLL-LLLLVLLFLPETLPEEK 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 227 ITPNERRFIESSGqarrpsdagreeqprpptpwwRIFTSVPFLVLVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGP 306
Cdd:cd17320 183 RKPLLSSLLRAYK---------------------RVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 307 LSALPYFAMILLTCVFIWLSDTLKQRGTVIplgfsrkffntLGMWLPMLALIGL-GYITEGEANVRLAIGLLTAAVATNS 385
Cdd:cd17320 242 LFALNAIALILGSLLNGRLVRRFGPRRLLR-----------LGLLLLLAAALVLlLAALLGGLSLWPLVAPLFLIFFGFG 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 761631414 386 ATYLGFHVNHIDLSPNYAGTLMGITNCAANFMSILAPLIVGLIvWDETnpaQWRIVFFFTAFVYFIGNLLFML 458
Cdd:cd17320 311 LIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLL-PNGT---ALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
63-214 |
4.27e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 42.69 E-value: 4.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 63 PDFPE-FDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLTPFCAvngGWTVVVVLRAVQGL 141
Cdd:cd17333 20 PSLEEaFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP---SIYLFVVLMFLAGL 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 761631414 142 CQGVIFPSTHTFLSKWAPaEERGRLVGYTYSGSQFGTVVMLSVSGYIASSSLGWPSTFYIPGCVGIVWSFVWL 214
Cdd:cd17333 97 GAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILIL 168
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
32-460 |
5.60e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 42.24 E-value: 5.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 32 ILVFFGLAVAYSLRVNLSVAIVAMTDrnasnpdfpEFDWNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMlFYGVL 111
Cdd:cd17341 2 HLSWLSFFLGFMVWFLFAPLGPVIRD---------DLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRV-FIASL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 112 ICSCLALLTPFCAVNGGWtVVVVLRAVQGLCqGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVV------MLSVS 185
Cdd:cd17341 72 LLLLIPLLALALAVSSYW-GLLVLGFLLGFA-GANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVsqllapLIAGA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 186 GYIASSSLGWPSTFYIPGCVGIVWSFVWLYLCSSTPaqhptitpnerrfiessgqarrpsdAGREEQPRPPTPWWRIFTS 265
Cdd:cd17341 150 IVFDGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLP-------------------------TGKASALEFLKVQLAVLKN 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 266 VPFLVLVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQRGtviplgfsRKFF 345
Cdd:cd17341 205 YRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRR--------RLWW 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 346 NTLGMWLPMLALIGLGYITEGEANVRLAIGLLtAAVATNSATYLGFHVNHiDLSPNYAGTLMGITNCAANFMSILAPLIv 425
Cdd:cd17341 277 LFIVMTIGAALLSLSLPTSGTNLVLFLALFVA-LGLGAGAGNGSVFRMVP-FIFRRELGAVTGLVGAIGGLGGFFLPLL- 353
|
410 420 430
....*....|....*....|....*....|....*
gi 761631414 426 glivwdetnpaqwrivFFFTAFVYFIGNLLFMLFG 460
Cdd:cd17341 354 ----------------FGSSALMTGSGVGAFSLFG 372
|
|
| PTZ00334 |
PTZ00334 |
trans-sialidase; Provisional |
228-281 |
6.96e-04 |
|
trans-sialidase; Provisional
Pssm-ID: 240366 [Multi-domain] Cd Length: 780 Bit Score: 42.19 E-value: 6.96e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 761631414 228 TPNERRFIESSGQARRpsdaGREEQPRPPTPWWRIFTSVPFLVLVLAHCANNWG 281
Cdd:PTZ00334 13 THNRRRVTGSSGRRRE----GRESEPQRPNMSRRVFTSAVLLLLVVMMCCGSGG 62
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
110-208 |
7.80e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 41.80 E-value: 7.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 110 VLICSCL--ALLTPFCAVNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVvmlsVSGY 187
Cdd:cd17365 66 VLLVSVAlfGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAA----LGGF 141
|
90 100
....*....|....*....|....
gi 761631414 188 IAS---SSLGWPSTFYIPGCVGIV 208
Cdd:cd17365 142 LAAaliPAFGWRSVFLLGGVPPLI 165
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
82-339 |
1.67e-03 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 40.95 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 82 FFWGYVVTQIPG---GYLSAIYGAKY-------MLFYGVLICSCLalltPFCAVNGGWTVVVVL--RAVQGLCQGVIFPS 149
Cdd:PRK10406 69 FAAGFLMRPIGGwlfGRIADKHGRKKsmlisvcMMCFGSLVIACL----PGYETIGTWAPALLLlaRLFQGLSVGGEYGT 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 150 THTFLSKWAPAEERGRLVGYTYS---GSQFGTVVMLSVSGYIASS----SLGWpstfYIPGCVGIVWSFVWLYLcsstpa 222
Cdd:PRK10406 145 SATYMSEVAVEGRKGFYASFQYVtliGGQLLALLVVVVLQQTLEDaelrEWGW----RIPFALGAVLAVVALWL------ 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 223 qhptitpnERRFIESSGQARRP-SDAGREEQprpptpWWRifTSVPFLVLVLAHCANNWGFWTLLTEIPTFMKNVLGMDI 301
Cdd:PRK10406 215 --------RRQLDETSQQETRAlKEAGSLKG------LWR--NRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHA 278
|
250 260 270
....*....|....*....|....*....|....*...
gi 761631414 302 KNNGPLSALPYFAMILLTCVFIWLSDTLKQRGTVIPLG 339
Cdd:PRK10406 279 NVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFG 316
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
93-203 |
1.99e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 40.33 E-value: 1.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 93 GGYLSAIYGAKYMLFYGVLICSCLALLTPFCAvngGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYS 172
Cdd:PRK11551 70 GGRLADRIGRKRILIVSVALFGLFSLATAQAW---DFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYC 146
|
90 100 110
....*....|....*....|....*....|.
gi 761631414 173 GSQFGTVVMlSVSGYIASSSLGWPSTFYIPG 203
Cdd:PRK11551 147 GVPFGGALA-SVIGVLAAGDAAWRHIFYVGG 176
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
269-459 |
2.05e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 40.69 E-value: 2.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 269 LVLVLAHCANNWGFwTLLTEIPTFMKNVLGmDIKNNGPLSALPYFAMILLTCVFIWLSDTlkqrgtviplgFSRKFFnTL 348
Cdd:cd06179 1 AALCLAYFAQLFGV-TLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDL-----------FGRRWF-FI 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 349 GMWLpmLALIGlgYITEGEA-NVRLAIGLLTAAVATNSATYLGFHVNHIDLSPNYAGTLMGITNCAANFMSILAPLIVGL 427
Cdd:cd06179 67 GGNL--LGVVG--SIVAGTAkSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGA 142
|
170 180 190
....*....|....*....|....*....|..
gi 761631414 428 IVwdETNPAQWRIVFFFTAFVYFIGNLLFMLF 459
Cdd:cd06179 143 LV--EANAAGWRWIFYINAIFNALALILLFFF 172
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
34-221 |
2.11e-03 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 40.47 E-value: 2.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 34 VFFGLAVAYSLRVNLSVAIVAM-TDRNASNPDFpefdwnestkSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLI 112
Cdd:cd17488 8 MFIGYAVFYLTRKSFNAAMPAMlADLGLDKSDI----------GILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 113 CSCLALLTPFcavNGGWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIASSS 192
Cdd:cd17488 78 TGIINILFGF---SSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTY 154
|
170 180
....*....|....*....|....*....
gi 761631414 193 lGWPSTFYIPGCVGIVWSFVWLYLCSSTP 221
Cdd:cd17488 155 -GWRAGMYVPGIIAILMGIVLCWRLRDRP 182
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
80-176 |
2.34e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 40.38 E-value: 2.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 80 SSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLTPFcAVNggWTVVVVLRAVQGLCQGVIFPSTHTFLSKWAP 159
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAF-SPN--YTVFLVFRLLVGMGIGGIWVQAVVLNTEFLP 210
|
90 100
....*....|....*....|
gi 761631414 160 AEERGR---LVGYTYSGSQF 176
Cdd:TIGR00898 211 KKQRAIvgtLIQVFFSLGLV 230
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
70-263 |
2.36e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 40.37 E-value: 2.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 70 WNESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICsclALLTPFCAVNGGWTVVVVLRAVQGLCQGVIFPS 149
Cdd:cd06180 31 LSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLT---VLLLAAMALTSGFAALLALRFLAGAASAFVFVF 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 150 THTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIASSSLGWPSTFYIPGCVGIVWSFVWLYLCSSTPAQHPTITP 229
Cdd:cd06180 108 GSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASA 187
|
170 180 190
....*....|....*....|....*....|....
gi 761631414 230 NERRfiessgqarrpsdagreeqPRPPTPWWRIF 263
Cdd:cd06180 188 AESA-------------------PGLNRPLWRLA 202
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
78-459 |
2.91e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.91 E-value: 2.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 78 LLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLTPFCAVNGGWTV--VVVLRAVQGLCQGVIFPSTHTFLS 155
Cdd:cd06173 39 VLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLwlLLVLAFLLGIASAFFGPARQALLP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 156 KWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIASssLGWPSTFYIPGCVGIVWSFVWLYLCSSTPAQHPTITPNERRFI 235
Cdd:cd06173 119 ELVPKEQLVRANALNSLATQLARIIGPALGGLLVA--LLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRD 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 236 ESSGqarrpsdagreeqprpptpwWRIFTSVPFLVLVLAHCANNWGFWTLLTE-IPTFMKNVLGMDIKNNGPLSALPYFA 314
Cdd:cd06173 197 LREG--------------------LRYLRRSPLLRLLLLALALFALLGGALTVlLPLLAKEVLGGGAAGYGLLLAAFGVG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 315 MILLTCVFIWLSDTLKqRGTVIPLGFSrkffnTLGMWLPMLALIGLGYITegeANVRLAIGLLTAAVATNSATYLgfhvn 394
Cdd:cd06173 257 ALLGALLLGRLSKRRR-RGRLLLIGAL-----LLGLALLVLGLSPSLWLL---LAALFLLGLAGGLFNVPLNTLL----- 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 761631414 395 HIDLSPNYAGTLMGITNCAANFMSILAPLIVGLIvwdeTNPAQWRIVFFFTAFVYFIGNLLFMLF 459
Cdd:cd06173 323 QLRVPDELRGRVFSVYNALNSGAMPLGALLAGLL----ADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
110-211 |
5.35e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.17 E-value: 5.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 110 VLICSCLA--LLTPFCAVNGGWTVVVvLRAVQGLCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSgSQFGTVVMLSVSGY 187
Cdd:cd17391 273 LLGALLASalLYIPQAFVQTPWQLGI-LRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQS-FQYLGNVAGPLLGS 350
|
90 100
....*....|....*....|....*..
gi 761631414 188 IASSSLGWPSTFYIPG---CVGIVWSF 211
Cdd:cd17391 351 AIAAHFGYRAVFVVTAllvLLNAIWSF 377
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
71-227 |
6.12e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 38.71 E-value: 6.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 71 NESTKSYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLfygvLICSCLALLTP-FCAVNGGWTVVVVLRAVQGLCQGVIFPS 149
Cdd:cd17315 32 STSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSL----LIAAVLYVIGAlLSALAPNVWVLIVGRFLLGLGVGLASVL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 761631414 150 THTFLSKWAPAEERGRLVgytySGSQ-FGTVVMLSVS----GYIASSSLGWPSTFYipgcVGIVWSFVWLYLCSSTPAQH 224
Cdd:cd17315 108 VPLYISEIAPAKIRGALG----TLNQlMITFGILLAYllglALSLSPPGWWRLMFA----LAAVPALLQLLLMFFLPESR 179
|
...
gi 761631414 225 PTI 227
Cdd:cd17315 180 ALL 182
|
|
| |
