NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|460002182|gb|AGH06158|]
View 

KCC2 transcript variant 9 [Homo sapiens]

Protein Classification

APC family permease( domain architecture ID 1903533)

APC (amino acid/polyamine/organocation) family permease is involved in the uptake of a specific amino acid and/or polyamine substrate with the concomitant import of a proton

Gene Ontology:  GO:0055085|GO:0022857
TCDB:  2.A.3

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
AA_permease_2 super family cl45918
Amino acid permease;
21-433 1.89e-153

Amino acid permease;


The actual alignment was detected with superfamily member TIGR00930:

Pssm-ID: 459263 [Multi-domain]  Cd Length: 953  Bit Score: 459.95  E-value: 1.89e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182   21 NPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPV-QAPRMGT 99
Cdd:TIGR00930   1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPPaGAVKFGW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182  100 FMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGA 179
Cdd:TIGR00930  81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182  180 VGLCFYLGTTFAGAMYILGTIEILLaylfpamAIFKaEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVF 259
Cdd:TIGR00930 161 IGLIFAFANAVAVAMYVVGFAETVL-------DLLR-ENGSKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182  260 LGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHgfdvcaklawegnetvttrlwglfcssrflnatcdeyftrnn 339
Cdd:TIGR00930 233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEIFSEN------------------------------------------ 270
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182  340 vtEIQGIPGAASGlikenlwssyltkgviversgmtsvgladgtpidmdhpyvfsdmtsyFTLLVGIYFPSVTGIMAGSN 419
Cdd:TIGR00930 271 --FIPGIPGPEGG-----------------------------------------------FFSLFGIFFPSVTGILAGAN 301
                         410
                  ....*....|....
gi 460002182  420 RSGDLRDAQKSIPV 433
Cdd:TIGR00930 302 ISGDLKDPQKAIPK 315
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
21-433 1.89e-153

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 459.95  E-value: 1.89e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182   21 NPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPV-QAPRMGT 99
Cdd:TIGR00930   1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPPaGAVKFGW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182  100 FMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGA 179
Cdd:TIGR00930  81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182  180 VGLCFYLGTTFAGAMYILGTIEILLaylfpamAIFKaEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVF 259
Cdd:TIGR00930 161 IGLIFAFANAVAVAMYVVGFAETVL-------DLLR-ENGSKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182  260 LGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHgfdvcaklawegnetvttrlwglfcssrflnatcdeyftrnn 339
Cdd:TIGR00930 233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEIFSEN------------------------------------------ 270
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182  340 vtEIQGIPGAASGlikenlwssyltkgviversgmtsvgladgtpidmdhpyvfsdmtsyFTLLVGIYFPSVTGIMAGSN 419
Cdd:TIGR00930 271 --FIPGIPGPEGG-----------------------------------------------FFSLFGIFFPSVTGILAGAN 301
                         410
                  ....*....|....
gi 460002182  420 RSGDLRDAQKSIPV 433
Cdd:TIGR00930 302 ISGDLKDPQKAIPK 315
AA_permease pfam00324
Amino acid permease;
102-286 2.88e-15

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 77.75  E-value: 2.88e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182  102 GVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVpAGGSYYMISRSLGPEFGGAVG 181
Cdd:pfam00324   1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182  182 LcFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEdasgeaaamlnnmrVYGTCVLTCMATVVFVGVKYVNKFALVFLG 261
Cdd:pfam00324  80 W-NYWLSWITVLALELTAASILIQFWELVPDIPYLW--------------VWGAVFLVLLTIINLVGVKWYGEAEFWFAL 144
                         170       180
                  ....*....|....*....|....*..
gi 460002182  262 CVILSILA--IYAGVIKSAFDPPNFPI 286
Cdd:pfam00324 145 IKIIAIIGfiIVGIILLSGGNPNDGAI 171
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
110-284 1.55e-08

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 56.44  E-value: 1.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182 110 NIFGVILFLRLTWVVGIAG--IMESFCMVFICCsctMLTAISMSAIATNgvVP-AGGSYYMISRSLGPEFGGAVGLCFYL 186
Cdd:COG0531   25 AIIGAGIFVLPGLAAGLAGpaAILAWLIAGLLA---LLVALSYAELASA--FPrAGGAYTYARRALGPLLGFLAGWALLL 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182 187 GTTFAGAMYILGTIEiLLAYLFPAMAIFkaedasgeaaamlnnmrVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILS 266
Cdd:COG0531  100 SYVLAVAAVAVAFGG-YLSSLFPAGGSV-----------------LIALVLILLLTLLNLRGVKESAKVNNILTVLKLLV 161
                        170
                 ....*....|....*...
gi 460002182 267 ILAIYAGVIkSAFDPPNF 284
Cdd:COG0531  162 LLLFIVVGL-FAFDPANF 178
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
21-433 1.89e-153

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 459.95  E-value: 1.89e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182   21 NPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPV-QAPRMGT 99
Cdd:TIGR00930   1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPPaGAVKFGW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182  100 FMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGA 179
Cdd:TIGR00930  81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182  180 VGLCFYLGTTFAGAMYILGTIEILLaylfpamAIFKaEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVF 259
Cdd:TIGR00930 161 IGLIFAFANAVAVAMYVVGFAETVL-------DLLR-ENGSKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182  260 LGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHgfdvcaklawegnetvttrlwglfcssrflnatcdeyftrnn 339
Cdd:TIGR00930 233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEIFSEN------------------------------------------ 270
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182  340 vtEIQGIPGAASGlikenlwssyltkgviversgmtsvgladgtpidmdhpyvfsdmtsyFTLLVGIYFPSVTGIMAGSN 419
Cdd:TIGR00930 271 --FIPGIPGPEGG-----------------------------------------------FFSLFGIFFPSVTGILAGAN 301
                         410
                  ....*....|....
gi 460002182  420 RSGDLRDAQKSIPV 433
Cdd:TIGR00930 302 ISGDLKDPQKAIPK 315
AA_permease pfam00324
Amino acid permease;
102-286 2.88e-15

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 77.75  E-value: 2.88e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182  102 GVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVpAGGSYYMISRSLGPEFGGAVG 181
Cdd:pfam00324   1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182  182 LcFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEdasgeaaamlnnmrVYGTCVLTCMATVVFVGVKYVNKFALVFLG 261
Cdd:pfam00324  80 W-NYWLSWITVLALELTAASILIQFWELVPDIPYLW--------------VWGAVFLVLLTIINLVGVKWYGEAEFWFAL 144
                         170       180
                  ....*....|....*....|....*..
gi 460002182  262 CVILSILA--IYAGVIKSAFDPPNFPI 286
Cdd:pfam00324 145 IKIIAIIGfiIVGIILLSGGNPNDGAI 171
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
110-284 1.55e-08

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 56.44  E-value: 1.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182 110 NIFGVILFLRLTWVVGIAG--IMESFCMVFICCsctMLTAISMSAIATNgvVP-AGGSYYMISRSLGPEFGGAVGLCFYL 186
Cdd:COG0531   25 AIIGAGIFVLPGLAAGLAGpaAILAWLIAGLLA---LLVALSYAELASA--FPrAGGAYTYARRALGPLLGFLAGWALLL 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 460002182 187 GTTFAGAMYILGTIEiLLAYLFPAMAIFkaedasgeaaamlnnmrVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILS 266
Cdd:COG0531  100 SYVLAVAAVAVAFGG-YLSSLFPAGGSV-----------------LIALVLILLLTLLNLRGVKESAKVNNILTVLKLLV 161
                        170
                 ....*....|....*...
gi 460002182 267 ILAIYAGVIkSAFDPPNF 284
Cdd:COG0531  162 LLLFIVVGL-FAFDPANF 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure