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Conserved domains on  [gi|440215759|gb|AGB94513|]
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endosulfine, isoform E [Drosophila melanogaster]

Protein Classification

endosulfine family protein( domain architecture ID 7824)

endosulfine family protein similar to Homo sapiens alpha-endosulfine and cAMP-regulated phosphoprotein 19, which are protein phosphatase inhibitor that specifically inhibit protein phosphatase 2A (PP2A) during mitosis

Gene Ontology:  GO:0051301|GO:0019888|GO:0000278|GO:0005102|GO:0004864|GO:0051721

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Endosulfine super family cl08423
cAMP-regulated phosphoprotein/endosulfine conserved region; Conserved region found in both ...
 33-118 1.97e-05

cAMP-regulated phosphoprotein/endosulfine conserved region; Conserved region found in both cAMP-regulated phosphoprotein 19 (ARPP-19) and Alpha/Beta endosulfine. No function has yet been assigned to ARPP-19. Endosulfine is the endogenous ligand for the ATP-dependent potassium (K ATP) channels which occupy a key position in the control of insulin release from the pancreatic beta cell by coupling cell polarity to metabolism. In both cases the region occupies the majority of the protein.


The actual alignment was detected with superfamily member pfam04667:

Pssm-ID: 398375  Cd Length: 80  Bit Score: 39.99  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215759   33 EEEKLKSKY---PSgmrvpggHSAFLQKRLQKgQKFFDSGDYQMAKQkggGVKQVFANKVTTGEAIPTPEtvparKTSII 109
Cdd:pfam04667   8 EELKLYKKYgklPK-------KKDLLSKKLQE-RKYFDSGDYALSKA---GVKKSQKSPGGLPSLHPSPE-----RTPHI 71


                  ....*....
gi 440215759  110 QPCNKFPAT 118
Cdd:pfam04667  72 QRRSSRSAC 80
 
Name Accession Description Interval E-value
Endosulfine pfam04667
cAMP-regulated phosphoprotein/endosulfine conserved region; Conserved region found in both ...
 33-118 1.97e-05

cAMP-regulated phosphoprotein/endosulfine conserved region; Conserved region found in both cAMP-regulated phosphoprotein 19 (ARPP-19) and Alpha/Beta endosulfine. No function has yet been assigned to ARPP-19. Endosulfine is the endogenous ligand for the ATP-dependent potassium (K ATP) channels which occupy a key position in the control of insulin release from the pancreatic beta cell by coupling cell polarity to metabolism. In both cases the region occupies the majority of the protein.


Pssm-ID: 398375  Cd Length: 80  Bit Score: 39.99  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215759   33 EEEKLKSKY---PSgmrvpggHSAFLQKRLQKgQKFFDSGDYQMAKQkggGVKQVFANKVTTGEAIPTPEtvparKTSII 109
Cdd:pfam04667   8 EELKLYKKYgklPK-------KKDLLSKKLQE-RKYFDSGDYALSKA---GVKKSQKSPGGLPSLHPSPE-----RTPHI 71


                  ....*....
gi 440215759  110 QPCNKFPAT 118
Cdd:pfam04667  72 QRRSSRSAC 80
 
Name Accession Description Interval E-value
Endosulfine pfam04667
cAMP-regulated phosphoprotein/endosulfine conserved region; Conserved region found in both ...
 33-118 1.97e-05

cAMP-regulated phosphoprotein/endosulfine conserved region; Conserved region found in both cAMP-regulated phosphoprotein 19 (ARPP-19) and Alpha/Beta endosulfine. No function has yet been assigned to ARPP-19. Endosulfine is the endogenous ligand for the ATP-dependent potassium (K ATP) channels which occupy a key position in the control of insulin release from the pancreatic beta cell by coupling cell polarity to metabolism. In both cases the region occupies the majority of the protein.


Pssm-ID: 398375  Cd Length: 80  Bit Score: 39.99  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440215759   33 EEEKLKSKY---PSgmrvpggHSAFLQKRLQKgQKFFDSGDYQMAKQkggGVKQVFANKVTTGEAIPTPEtvparKTSII 109
Cdd:pfam04667   8 EELKLYKKYgklPK-------KKDLLSKKLQE-RKYFDSGDYALSKA---GVKKSQKSPGGLPSLHPSPE-----RTPHI 71


                  ....*....
gi 440215759  110 QPCNKFPAT 118
Cdd:pfam04667  72 QRRSSRSAC 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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