|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
444-840 |
4.06e-90 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 294.46 E-value: 4.06e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 444 GWIICGVSFLVHILTTGLQLSYGLLWFYAVQYLH-NTSGIELLGALSWSVSMVATSFVVSLCRKRSIRLLSIVGGLVMPL 522
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGeSTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 523 GILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAGWRLGL 602
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 603 QIVAALTALSFFMGLMYRpaslyhpqrraiqhlknqrkkmrekkpilsqdvestpkyffldisSLKSVTVKILLMTSSVA 682
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR---------------------------------------------LLKDPTFVLLALGVSFA 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 683 SFGIYTPMFLMALNAAEQGSDVQELVLLQTFLGISMALGVVIAGALLRRCfviRHFVINTKIVTqlfLSIVALAILFLSF 762
Cdd:cd17352 196 MLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKP---RIGRLYLYIFT---LLILGLSLLAFPL 269
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1833085134 763 VMGYTGLCILSWLYGIGLGGFQYSLKILALERIKLKHFSKAWGFIRGVESVPVLISVPLTSFLNDYSLKYgRAGYYIC 840
Cdd:cd17352 270 ATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDY-DAAFYFC 346
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
434-840 |
8.76e-29 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 121.39 E-value: 8.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 434 RQYFYPDGGWGWIICGVSFLvhilTTGLqlSYGL-----LWFYAVQYLHNTSGIELlgalSWSVS-----MVATSFVVS- 502
Cdd:TIGR00892 7 PEGPPPDGGWGWVVLGATFV----SIGF--SYAFpkavtVFFKELQQIFQATYSET----AWISSimlavLYAGGPISSi 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 503 LCRKRSIRLLSIVGGLVMPLGILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVGI 582
Cdd:TIGR00892 77 LVNRFGCRPVVIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 583 ALFSVILKEGVGKAGWRLGLQIVAALTALSFFMGLMYRPASlyhPQRRAIQHLKNQRKKMREKKPILSQdvESTPKYF-- 660
Cdd:TIGR00892 157 STLAPLNQYLFESFGWRGSFLILGGLLLHCCVCGALMRPVG---PSQRVSKSKSKEGLPPDGSTKKLSK--KSTAEKInr 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 661 FLDISSLKSVTVKILLMTSSVASFGIYTPMFLMALNAAEQGSDVQELVLLQTFLGISMALGVVIAGALLRRCFVIRHfvi 740
Cdd:TIGR00892 232 FLDFSLFTHRGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPH--- 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 741 ntkiVTQLFlsivALAILF------LSFVMG-YTGLCILSWLYGIGLGG-----FQYSLKILALERiklkhFSKAWGFIR 808
Cdd:TIGR00892 309 ----VQYLF----SFALLFnglthlLCALAGdYTGLVIYCIFFGLSFGSvgallFEVLMDLVGAQR-----FSSAVGLVT 375
|
410 420 430
....*....|....*....|....*....|..
gi 1833085134 809 GVESVPVLISVPLTSFLNDYSLKYgRAGYYIC 840
Cdd:TIGR00892 376 IVECCAVLIGPPLAGRLVDATKNY-KYIFYAS 406
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
444-836 |
1.21e-23 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 104.92 E-value: 1.21e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 444 GWIICGVSFLVHILTTGLQLSYGLLWFYAVQYLHN------TSGIELLGALSWSVSMVATSFVVSLCRKRSIRLLSIVGG 517
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKlgdpeaSFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 518 LVMPLGILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAG 597
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 598 WRLGLQIVAALTALSFFMGLMYRPAslyhpqrraiqHLKNQRKKMREKKPILSQDVESTPKYFFlDISSLKSVTVKILLM 677
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPL-----------HPSPEDPKSKPGRRTLHSRINLFLRKIF-NVEIFKRKRYVIWAL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 678 TSSVASFGIYTPMFLMALNAAEQGSDVQELVLLQTFLGISMALGVVIAGallrrcfVIRHFV--INTKIVTQLFLSIVAL 755
Cdd:cd17420 229 GIPLALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFG-------VIADMPpgVKKMYLQVLSFVSIGL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 756 AILFLSFVMGYTGLCILSWLYGIGLGGFQYSLKILALERIKLKHFSKAWGFIRGVESVPVLISVPLTSFL----NDYSLK 831
Cdd:cd17420 302 MSMMIPLCNSFGILISVCLVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLrdstGSYTVA 381
|
....*
gi 1833085134 832 YGRAG 836
Cdd:cd17420 382 FYLAG 386
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
447-840 |
6.74e-22 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 99.04 E-value: 6.74e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 447 ICGVSFLVHILTTGLqlsYGLLWFYAVQYLHNTSGIELLGALSWSVSMVATSFVVSLCRKRSIRLLSIVGGLVMPLGILF 526
Cdd:cd06174 1 LLLGFFLTGLARGLI---SPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 527 TSFATEFGQVVFSYgIVFGVGVAMVREASTVMLGNYFKRRRQ-----FVEMVAMSGEGVGIALFSVILKEGVgkAGWRLG 601
Cdd:cd06174 78 FAFAPSFWLLLLGR-FLLGLGSGLIDPAVLALIADLFPERERgralgLLQAFGSVGGILGPLLGGILASSLG--FGWRAV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 602 LQIVAALTALSFF-MGLMYRPASLYHPQRRAIQHLKNQRKKMREkkpilsqdVESTPKYFFLDISslksvtvkILLMTSS 680
Cdd:cd06174 155 FLIAAALALLAAIlLLLVVPDPPESARAKNEEASSKSVLKLLKR--------VLKNPGLWLLLLA--------IFLVNLA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 681 VASFGIYTPMFLMALNaaeqGSDVQELVLLQTFLGISMALGVVIAGALLRRCFVIRHFvintkIVTQLFLSIVALAILFL 760
Cdd:cd06174 219 YYSFSTLLPLFLLDLG----GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPL-----LLIGLLLMALGLALLLL 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 761 SFVMGYTGLCILswLYGIGLGGFQYSLKILALERIKLKHFSKAWGFIRGVESVPVLISVPLTSFLNDYSLKYgRAGYYIC 840
Cdd:cd06174 290 APSLLLLLLLLL--LLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGL-TGAFLVL 366
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
444-839 |
2.83e-21 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 97.46 E-value: 2.83e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 444 GWIICGVSFLVHILTTGLQLSYGLLWFYAVQYLHNTSG-IELLGALSWSVSMVATSFVVSLCRKRSIRLLSIVGGLVMPL 522
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQrVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 523 GILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAGWRLGL 602
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 603 QIVAALTALSFFMGLMYRPASLYHPQRRAIQHLknqrkkmrekkpilsqdvestpkYFFLDISSLKSVTVKILLMTSSVA 682
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPLALPGDPPAPPRSL-----------------------SAAFGLSLLTHRAFLRYALATTLI 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 683 SFGIYTPMFLMALNAAEQGSDVQELVLLQTFLGISMALGVVIAGALL-RRCFVIRHFVIntkivtqLFLSIVALAILFLS 761
Cdd:cd17423 218 NTGYFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLAdLGPLRLLHLLV-------LWTALTGLSLLLLP 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 762 FVMGYTGLCILSWLYGIGLGG-----FQYSLKILALERIklkhfSKAWGFIRGVESVPVLISVPLTSFLND----YSLKY 832
Cdd:cd17423 291 LAKVYGSLLALAVAYGFCAGAlaplvFSVLPELVGVERV-----LNATGLLQMIESVGGLLGPPLSGWLRDitgdYTASF 365
|
....*..
gi 1833085134 833 GRAGYYI 839
Cdd:cd17423 366 LVAGSFL 372
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
444-837 |
3.87e-21 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 97.17 E-value: 3.87e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 444 GWIICGVSFLVHILTTGLQLSYGLLWFYAVQYLHNTSGIELLGALSW--SVSMVATSF---VVSL------CRKrsirlL 512
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKDDAQMRFKTAWvgSLSMGMIFFcspIVSVftdlfgCRK-----T 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 513 SIVGGLVMPLGILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEG 592
Cdd:cd17464 76 ATGGAAVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 593 VGKAGWRLGLQIVAALTALSFFMGLMYRPASlyhPQRRaiqhlKNQRKKMREKKPILSQdvestpkyfFLDISSLKSVTV 672
Cdd:cd17464 156 LDSVGLFNTLRVLCIFMFVLFLAGFTYKPLV---PMKK-----DKEGKKRKFKCPPLKK---------IFNFNIWKSTGY 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 673 KILLMTSSVASFGIYTP-MFLMALNAAEQGSDVQELVLLQTfLGISMALGVVIAGALLRrcFVIRHFVINTKIVTQLFLS 751
Cdd:cd17464 219 RIWAFGIPAALFGYFVPyVHLMNHVKERFGEDVNKEVLLMC-IGITSGIGRLIFGRVAD--YIPGVKKVYLQVSSFFFIG 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 752 IVALAILFLSFVMGYTGLCILSWLYGiglGGFQYSLKILALERIKLKHFSKAWGFIRGVESVPVLISVPLTSFLNDYSLK 831
Cdd:cd17464 296 LMSMMIPLCHVFGGLIAVCLFMGLFD---GCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGS 372
|
....*.
gi 1833085134 832 YGRAGY 837
Cdd:cd17464 373 YDVAFY 378
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
444-840 |
1.37e-20 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 94.90 E-value: 1.37e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 444 GWIICGVSFLVHILTTGLQLSYGLLWFYAVQYLHNTSGIEL-LGALSWSVSMVATSFVVSLCRKRSIRLLSIVGGLVMPL 522
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAwISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 523 GILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAGWRLGL 602
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 603 QIVAALTALSFFMGLMYRpaslyhpqrraiqhlknqrkkmrekkpilsqdvestpkyFFLDISSLKSVTVKILLMTSSVA 682
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR---------------------------------------LFTNKVFVAFIFWALFAYCSFVI 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 683 SFgIYTPMFLMALNAAEQgsdvQELVLLQTFLGISMALGVVIAGallrrcFVIRHFVINTKIVTQLFLSIVALAILFLSF 762
Cdd:cd17429 202 PF-IHLPEIVKLYGLSEQ----NDKFPLTSIIAIVHIFGKVILG------IICDLPCISVWNVFILANFTLGVCILILPL 270
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1833085134 763 VMGYTGLCILSWLYGIGLGGFQYsLKILALERIKLKHFSKAWGFIRGVESVPVLISVPLTSFLNDYSLKYGRAgYYIC 840
Cdd:cd17429 271 MHTYTGLAIVCALIGFSSGYFSL-MPVVTEDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFS-FYVC 346
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
450-818 |
1.26e-19 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 91.71 E-value: 1.26e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 450 VSFLVHILTTGLQLSYGLLWFYAVQYLHNT-SGIELLGALSWSVSMVATSFVVSLCRKRSIRLLSIVGGLVMPLGILFTS 528
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISpTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 529 FATEFGQVVFSyGIVFGVGVAMVREASTVMLGNYF-KRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAGWRLGLQIVAA 607
Cdd:pfam07690 81 FASSLWLLLVL-RVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 608 LTALSFFMGLMYRPASlyhpqrraiqhlKNQRKKMREKKPILsqdvestpkyFFLDISSLKSVTVKILLMTSSVASFGIY 687
Cdd:pfam07690 160 LSLLAAVLLLLPRPPP------------ESKRPKPAEEARLS----------LIVAWKALLRDPVLWLLLALLLFGFAFF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 688 TPMFLMALNAAEQGSDVQELVLLQTFLGISMALGVVIAGALLRRcFVIRhfviNTKIVTQLFLSIVALAILFLSFVMGYT 767
Cdd:pfam07690 218 GLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDR-LGRR----RRLLLALLLLILAALGLLLLSLTLSSL 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1833085134 768 GLCILSWLYGIGLGGFQYSLKILALERIKLKHFSKAWGFIRGVESVPVLIS 818
Cdd:pfam07690 293 WLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
444-840 |
1.33e-18 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 89.04 E-value: 1.33e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 444 GWIICGVSFLVHILTTGLQLSYGLLWFYAVQYLHntsgiELLGALSWSVS-----MVATSFVVSLCRKR-SIRLLSIVGG 517
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFN-----ETNSRVSWIISicvfvMTFTAPLSTVLSNRfGHRPVVMVGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 518 LVMPLGILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAG 597
Cdd:cd17422 76 LLISLGMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 598 WRLGLQIVAALTALSFFMGLMYRpaslyhpqrraiqhlknqrkKMREKKPILsqdvestpkYFFLDIsslksvtvkillm 677
Cdd:cd17422 156 WRYCLLVVGALQLNIVVCGALLR--------------------VLKEPGFIC---------YALFGL------------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 678 tssVASFGIYTP-MFLMALNAAEQGSDVQELVLLQTfLGISMALGVVIAGALLRRCfVIRHFVINTKIVTqlflsIVALA 756
Cdd:cd17422 194 ---FATLGFFAPqLYIIPLSLSLGIDQDWAAYMLSA-MAIAELFGRISAGWVLNKC-PIRKIYIELICVI-----LLCVV 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 757 ILFLSFVMGYTGLCILSWLYGIGLGGFQYS-LKILALERI-KLKHFSKAWGFIRGVESVPVLISVPLTSFLNDYSLKYGR 834
Cdd:cd17422 264 LLLFPFAYGFWSLLVCSIFYGFMFGTVAGThIPLLAEDDVvGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGS 343
|
....*.
gi 1833085134 835 AgYYIC 840
Cdd:cd17422 344 A-FYSC 348
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
445-794 |
7.05e-18 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 86.57 E-value: 7.05e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 445 WIICGVSFLVHILTTGLQLSYGLLWFYAVQYLHNTSGIELLGALSWSVSMVATSFVVSLCRKRSIRLLSIVGGLVMPLGI 524
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 525 LFTSFATEFGQVVFSyGIVFGVGVAMVREASTVMLGNYF-KRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAGWRLGLQ 603
Cdd:COG2814 90 LLCALAPSLWLLLAA-RFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 604 IVAALTALSFFMGLMYRPASLYHPQRRAIQHLKnqrkkmrekkpilsqdvestpkyffldiSSLKSVTVKILLMTSSVAS 683
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRPAARARLRGSLR----------------------------ELLRRPRLLLLLLLAFLLG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 684 FGIYTPMFLMALNAAEQ-GSDVQELVLLQTFLGISMALGVVIAGALLRRcfvirhfvINTKIVTQLFLSIVALAILFLSF 762
Cdd:COG2814 221 FGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLADR--------FGRRRLLLIGLLLLALGLLLLAL 292
|
330 340 350
....*....|....*....|....*....|..
gi 1833085134 763 VMGYTGLCILSWLYGIGLGGFQYSLKILALER 794
Cdd:COG2814 293 AGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
441-829 |
3.33e-17 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 84.92 E-value: 3.33e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 441 GGWGWIICGVSFLVHILTTGLQLSYGLLWFYAVQYLHNTSGIELLGALSWSVSMVATSFVV-SLCRKRSIRLLSIVGGLV 519
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAgLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 520 MPLGILFTSFATEFGQVVFSYgIVFGVGVAMVREASTVMLGNYF-KRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAGW 598
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 599 RLGLQIVAALTALSFFMGLMYrpASLYhpqrraiqhlknqrkkmrekkpilsqdvestpkYFFLDISslksvtvkillmt 678
Cdd:COG2271 164 RAAFLILGLPGLLLALLRFWL--LALA---------------------------------YFLVYFA------------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 679 ssVASFGIYTPMFLMAlnaaEQGSDVQELVLLQTFLGISMALGVVIAGALLRRcfvirhFVINTKIVTQLFLSIVALAIL 758
Cdd:COG2271 196 --LYGFLTWLPTYLVE----VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR------LGRRRKLVLAIGLLLAALALL 263
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1833085134 759 FLSFVMGYTGLCILSWLYGIGLGGFQYSLKILALERIKLKHFSKAWGFIRGVESVPVLISVPLTSFLNDYS 829
Cdd:COG2271 264 LLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT 334
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
444-838 |
6.39e-15 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 78.08 E-value: 6.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 444 GWIICGVSFLVHILTTGLQLSYGLLWFYAVQYLH-NTSGIELLGALSWSVSMVATSFVVSLCRKRSIRLLSIVGGLVMPL 522
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGwSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 523 GILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNY-FKRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAGWRLG 601
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWwFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 602 LQIVAALtalsffMGLMYRPASLYHPQRRAIQHLknqrkkmREKKPILSQDVESTPKyffldiSSLKSVTVKILLMTSSV 681
Cdd:cd17355 161 LLVLALL------ALLVLVPVLLLLRRRPADLAL-------RAYDDASPASPGSTLK------EALRSASFWLLALAFFL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 682 ASFGIYTPMF-LMALnAAEQGSDVQELVLLQTFLGISMALGVVIAGALLRRcfvirhfvINTKIVTQLFLSIVALAILFL 760
Cdd:cd17355 222 CGFAVVGLIVhLVPY-LADRGISPAAAAVALALIGLFNIVGRLLSGWLGDR--------YSPRRLLAASYALRALGLALL 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1833085134 761 SFV-MGYTGLCILSWLYGIGLGGFQYSLKILALERIKLKHFskawGFIRGVESVPVLISVPLTSFLndYSLKYGRAGYY 838
Cdd:cd17355 293 LLLpFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSY----GTLFGLVFAPHQLGSALGPWL--GGLLYDRTGSY 365
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
454-840 |
1.89e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 76.84 E-value: 1.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 454 VHILTTGLQLSYGllwfyaVQYLHNTSGIELLGALSWSVS----MVATSFVVS---------LCRKRSIRLLSIVGGLVM 520
Cdd:COG2223 7 LLLATLAFFLAFG------VWYLWSVLAPPLAEEFGLSAAqlglLFAIPVLVGallriplgfLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 521 PLGILFTSFATEFGQVVFsYGIVFGVGVAMVREASTVMLGNYFKRRRQ-FVEMVAMSGEGVGIALFSVILKEGVGKAGWR 599
Cdd:COG2223 81 GIGLLLLALAVSYWLLLL-LGLLLGIGGGGSFAVGIALVSKWFPPDRRgLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 600 LGLQIVAALTALSFFMGLMYrpaslyhpqrraiqhlknqrkkMREKKPILSQDVESTPKYFFldiSSLKSVTVKILLMTS 679
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLF----------------------LRDPPAGAAAAAKASLRDQL---EALRDPRFWLLSLLY 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 680 SVASFGIYTPMFLMALNAAEQ-GSDVQELVLLQTFLGISMALGVVIAGALLRRcfvirhfvINTKIVTQLFLSIVALAIL 758
Cdd:COG2223 215 FGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDR--------IGGRRVLLIVFALMALGLL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 759 FLSFVMG-----YTGLCILSWLYGIGLGGFqYSlkiLALERIKLKHFSKAWGFIRGVESVPVLISVPLTSFLNDYSLKYg 833
Cdd:COG2223 287 LLALALGslwlfLVLFLLLGLALGGGNGAV-FA---LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSY- 361
|
....*..
gi 1833085134 834 RAGYYIC 840
Cdd:COG2223 362 TAAFLVF 368
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
503-840 |
3.53e-14 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 75.68 E-value: 3.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 503 LCRKRSIRLLSIVGGLVMPLGILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVGI 582
Cdd:cd17426 61 LVNKYGSRPIMIAGGCLSGAGLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFL 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 583 ALFSVILKEGVGKAGWRLGLQIVAALTALSFFMGLMYRPASlyhpqrraiqhlknqrkkmreKKPilsqdvestpkyfFL 662
Cdd:cd17426 141 STLAPLNQWFFDIFGWRGSFLILGGLLLNCCVAGSLMRPIG---------------------PKP-------------FL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 663 DISSLKSVTVKILLMTSSVASFGIYTPMFLMALNAAEQGSDVQELVLLQTFLGISMALGVVIAGallrrcfvirhFVINT 742
Cdd:cd17426 187 DLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMG-----------IVANT 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 743 KIV---TQLFLSIVALAI----LFLSFVMGYTGLCILSWLYGIGLGGFQYSLKILALERIKLKHFSKAWGFIRGVESVPV 815
Cdd:cd17426 256 KWVrprIQYFFAASVLYNgvchLLAPLSTSYVGFCIYAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPV 335
|
330 340
....*....|....*....|....*
gi 1833085134 816 LISVPLTSFLNDYSLKYgRAGYYIC 840
Cdd:cd17426 336 LLGPPLLGRLNDIYGDY-KYTYWAC 359
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
445-807 |
8.96e-14 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 74.57 E-value: 8.96e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 445 WIICGVSFLVHiLTTGLQLSYGLLWFYAVQYLHNTSGIELLGALSWSVSMVATSFVVSLCRKR-SIRLLSIVGGLVMPLG 523
Cdd:cd17353 3 WLVLLGAVLMH-LILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRgGPRKAILIGGILFGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 524 ILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAGWRLGLQ 603
Cdd:cd17353 82 FILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 604 IVAALTALSFFMG--LMYRPASLYHPQrrAIQHLKNQRKKMREKKPilSQDVESTPKYFFLdisslksvtvkiLLMTSSV 681
Cdd:cd17353 162 ILGIIFLIIIVIGafLIRDPPKGWVPP--GVDPLANNAENSPRDYT--PREMLRTPTFWLL------------WLMFFLN 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 682 ASFGIYTPMFLMALNAAEQGSDVQELVLLQTFLGISMALGVVIAGAL---LRRcfvirhfvINTKIVTQLFLSIVALAIL 758
Cdd:cd17353 226 ATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLsdkIGR--------KNTLSIAFLIQGVAMFLLP 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1833085134 759 FlsFVMGYTGLCILSWLYGIGLGGFqYSLkILAL--ERIKLKHFSKAWGFI 807
Cdd:cd17353 298 F--IGSVAVLFVLGVALIGFCYGGG-FAL-FPALtaDFFGTKNAGTNYGLL 344
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
444-840 |
1.44e-13 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 73.99 E-value: 1.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 444 GWIICGVSFLVHILTTGLQLSYGLLWFYAVQYLHntsgiELLGALSWSVSMVA-----TSFVVSLC-RKRSIRLLSIVGG 517
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFG-----YSSSQIATAASLSNlgmllTQPILGFIaDSFGPRPLMALAG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 518 LVMPLGILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAG 597
Cdd:cd17314 76 IMVLAGYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 598 WRLGLQIVAALTALSFFMGLMYRPAslyHPQRraiqhlKNQRKKMREKKPILSQDVESTPKYFFLdisslksvtvkillm 677
Cdd:cd17314 156 LALVYTILGILAAIVLSVVSLLGFK---EPPD------NQARLHVQKKKTQTMGEIFRDKVFWIL--------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 678 tsSVASFGIYTPMFLMALNAAE-----QGSDVQELVLLQTFLGISMALGVVIAGallrrcfVIRHFVINT--KIVTQLFL 750
Cdd:cd17314 212 --FIAIFLVLIGGFLFIANMASlvrslQLDAPSFVTKLMSIYGLFNAFGRLLWG-------IVADFFGGRlsTLSILLTI 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 751 SIVALAILFLSFVMGYTGLCILSWLYGIGLGGFQYSLKILALERIKLKHFSKAWGFIRGVESVPVLISVPLTSFLNDYSL 830
Cdd:cd17314 283 LGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTP 362
|
410
....*....|
gi 1833085134 831 KYGRAgYYIC 840
Cdd:cd17314 363 SYISA-VYIY 371
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
497-832 |
2.56e-13 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 72.84 E-value: 2.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 497 TSFVVSLCRKR-SIRLLSIVGGLVMPLGILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAM 575
Cdd:cd17430 54 TGPLCSILVNRfGCRPVMLVGGLLASLGMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAA 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 576 SGEGVGIALFSVILKEGVGKAGWRLGLQIVAALTALSFFMGLMYRPaslyhpqrraiqhlknqrkkmrekkpilsqdves 655
Cdd:cd17430 134 AGSPVFLSALSPLGQILLEEYGWRGGFLILGGLLLNCCTCGAVMRP---------------------------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 656 tpkyffLDISSLKSVTVKILLMTSSVASFGIYTPMFLMALNAAEQGSDVQELVLLQTFLG----ISMALGVVIAGALLRR 731
Cdd:cd17430 180 ------LDFSVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKDIGVPDTEAAFLLSILGfidiFARPACGVVAGLKWVR 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 732 CFVIRHFvintkivtqlflsivALAILF--LSFVMG-----YTGLCILSWLYGIGLG-----GFQYSLKILALERiklkh 799
Cdd:cd17430 254 PRVVYLF---------------SFAMLFngLTDLCSataadYGGLVVFCVFFGISYGmvgalQFEVLMAIVGTQK----- 313
|
330 340 350
....*....|....*....|....*....|...
gi 1833085134 800 FSKAWGFIRGVESVPVLISVPLTSFLNDYSLKY 832
Cdd:cd17430 314 FSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNY 346
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
447-827 |
3.69e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 72.61 E-value: 3.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 447 ICGVSFLVHIlttGLQLSYGLLWFYAVQyLHNTSGieLLGAL--SWSVSMVATSFVV-SLCRKRSIRLLSIVGGLVMPLG 523
Cdd:cd17325 1 LSLALFLDML---GYGIIIPILPLYAES-LGASVA--QIGLIvaAYALAQLLFSPPAgRLSDRFGRKRLLLLGLLLLAVS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 524 ILFTSFATEFGQVVFSYgIVFGVGVAMVREASTVMLGNYFKRRRQFVEM-VAMSGEGVGIA---LFSVILkegVGKAGWR 599
Cdd:cd17325 75 TLLFAFATSYWQLLLAR-FLQGLASAAVWPAAMALIADIAPPEERGRAMgIFSSAIGLGFLigpLLGGLL---ADALGYR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 600 LGLQIVAALTALSFFMGLMYRPASlyhpqrraiqhlknqrKKMREKKPILSQDVESTPKYFFLDiSSLKSVTVKILLMTS 679
Cdd:cd17325 151 APFLVCAALALLALVLALLLLPEP----------------RPPPNKRAVSAARLRSGLRLLLRD-RRLLALFLAIFVLAF 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 680 SVASFGIYTPMFLMALNaaeqGSDVQELVLLQTFLGISMALGVVIAGALLRRcfvirhfvINTKIVTQLFLSIVALAILF 759
Cdd:cd17325 214 AFGALEPFLPLYAAELG----GLSPAQIGLLFGAQGLASALSQPPAGKLSDR--------IGRKPLILIGLLLSAVALLL 281
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1833085134 760 LSFVMGYTGLCILSWLYGIGLGGFQYSLKILALERIKLKHFSKAWGFIRGVESVPVLISVPLTSFLND 827
Cdd:cd17325 282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD 349
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
444-838 |
4.98e-13 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 72.16 E-value: 4.98e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 444 GWIICGVSFLVHILTTGLQLSYGLL---WFYAVQylhntsgiELLGALSWSVSMVA-----TSFVVSLCRKR-SIRLLSI 514
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLypeWLDAFG--------EGKGMTAWVGSLASgvgliASPVCSACVSSfGARPVTI 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 515 VGGLVMPLGILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEGVG 594
Cdd:cd17428 73 FSGFMVAGGLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 595 KAGWRLGLQIVAALTALSFFMGLMYRpaslyhpqrraiqHLKNQrkkmrekkpilsqdvestpkyffldisSLKSVTVKI 674
Cdd:cd17428 153 LYGLDGCLLIVGALALNLLACGSLMR-------------LFKNR---------------------------VFSALFIAI 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 675 LLMtssvaSFGIYTPMFLMALNAAEQGSDVQELVL-LQTFLGISMALGVVIAGALLRRCFVirhfviNTKIVTQLFLSIV 753
Cdd:cd17428 193 LLF-----DIGAFPPSLLMEDVARSENIIEEIALIpLVSIIGITTAIGKLILGVLADFKWV------NSLYLYVLTLIGM 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 754 ALAILFLSFVMGYTGLCILSWLYGIGLGG---FQY-SLKILALERIklkhfSKAWGFIRGVESVPVLISVPLTSFLNDYS 829
Cdd:cd17428 262 GAALLAIPFAKSYLTLAVLSAILGFLSGNwsiFPYvTTKTVGIEKL-----GHAYGILMFFAGLGNSLGPPIVGWFYDWT 336
|
....*....
gi 1833085134 830 LKYGRAGYY 838
Cdd:cd17428 337 QTYDIAFYF 345
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
444-621 |
7.63e-13 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 71.39 E-value: 7.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 444 GWIICGVSFLVHILTTGLQLSYGLlWFYAVQYLHNTSG--IELLGALSWSVSMVATSFVVSLCRKRSIRLLSIVGGLVMP 521
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGI-FFVAFQEEFGGSSeqISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 522 LGILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVGIAL--FSVILKEgvgKAGWR 599
Cdd:cd17421 80 AGFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTFALapFTQLLLD---EYDWQ 156
|
170 180
....*....|....*....|..
gi 1833085134 600 LGLQIVAALTALSFFMGLMYRP 621
Cdd:cd17421 157 GALLIFGGIMLNLVASGMLLRP 178
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
460-838 |
2.24e-12 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 70.21 E-value: 2.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 460 GLQLSYGLLWFYAVQYLHNT--SGIELLGALSWSVSMVATSF---VVSLCRKR-SIRLLSIVGGLVMPLGILFTSFATEF 533
Cdd:cd17465 17 GIQNSFGILYVMLLNEQEDQkdQAVQFKTAWVGALAMGMIFFcspVVSIFTDRfGCRKTAMGGAAVAFIGLLSSSFTKSL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 534 GQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAGWRLGLQIVAALTALSF 613
Cdd:cd17465 97 GLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIGLAHTFQVLSLFMFIQI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 614 FMGLMYRpaslyhpqrraiqhlknqrkkmrekkpilsqdvestpkyffldisSLKSVTVKILLMTSSVASFGIYTPMFLM 693
Cdd:cd17465 177 FLSLTYK---------------------------------------------VFRRKTYRIWAFGIATAVLGYFVPYVHL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 694 ALNAAEQGSDVQELVLLQTFLGISMALGVVIAGAllrrcfvIRHFVINTKIVTQLFLSIVALAIL--FLSFVMGYTGLCI 771
Cdd:cd17465 212 MKYVEEEFKENKREWVLLVCIGASSGIGRLMSGK-------IGDLIPGLKKIYLQVASFLLLGIMsmMIPLCQVFEGVIV 284
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1833085134 772 LSWLYGIGLGGFQYSLKILALERIKLKHFSKAWGFIRGVESVPVLISVPLTSFLNDYSLKYGRAGYY 838
Cdd:cd17465 285 VCLFLGLCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYL 351
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
510-833 |
5.68e-12 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 68.64 E-value: 5.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 510 RLLSIVGGLVMPLGILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVGIALFSVIL 589
Cdd:cd17425 68 RVTVMLGGLLSGVGMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLS 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 590 KEGVGKAGWRLGLQIVAALTALSFFMGLMYRPasLYHPQRRAIQHLknqrkkmrekkpilsqdvestpkyffldisslkS 669
Cdd:cd17425 148 QYLLEEMGWRGSFLVFGGVLLNCCVCGAVMRP--FCSNTRYQIYTL---------------------------------G 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 670 VTVKILlmtssvasfGIYTPMFLMALNAAEQGSDVQELVLLQTFLGISMALGVVIAGALlrrcFVIRHFVINTKIVTQLF 749
Cdd:cd17425 193 VTWMVL---------GFVLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLL----SGLPVFKGRRIYLFSLA 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 750 LSIVALAILFLSFVMGYTGLCILSWLYGIGLGGFQYSLKILALERIKLKHFSKAWGFIRGVESVPVLISVPLTSFLNDYS 829
Cdd:cd17425 260 LLLNGLSNLICAISASFPVLLVYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDIT 339
|
....
gi 1833085134 830 LKYG 833
Cdd:cd17425 340 QQYS 343
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
444-840 |
1.77e-11 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 67.14 E-value: 1.77e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 444 GWIICGVSFLVHILTTGLQLSYGLLWF-YAVQYLHNTSGIELLGALSWSVSMVATSFVVSLCRKRSIRLLSIVGGLVMPL 522
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVeFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 523 GILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAGWRLGL 602
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 603 QIVAALTALSFFMGLMYRpaslyhpqrraiqhlknqrkkmrekkpilsqdvestpkyfFLDISSLKSVTVKILLMtssva 682
Cdd:cd17424 161 LILGGFVLNLCVCGALMR----------------------------------------FLLMPDFLVLAVSVLFL----- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 683 SFGIYTPMFLMALNAAEQGSDVQELVLLQTFLGISMALGVVIAGALLRRCFVIRHfvinTKIVTQLFLSIVALAILFLSF 762
Cdd:cd17424 196 AYGCSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKY----RYFCYLFAVGMDGLCCLFLPI 271
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1833085134 763 VMGYTGLCILSWLYGIGLGGFQYSLKILALERIKLKHFSKAWGFIRGVESVPVLISVPLTSFLNDYSLKYgRAGYYIC 840
Cdd:cd17424 272 LKTFPLLVPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTY-TAAFLLS 348
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
444-840 |
2.89e-11 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 66.76 E-value: 2.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 444 GWIICGVSFLvhilttGLQLSYGL-----LWFYAVQYLHNTSGIEL--LGALSWSVSMVATSFVVSLCRKRSIRLLSIVG 516
Cdd:cd17427 1 GWAVVFGAFI------SIGFSYAFpkaitVFFKEIQEIFHTSYSEIawISSIMLAVMYAGGPISSILVNKYGSRPVVIAG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 517 GLVMPLGILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEGVGKA 596
Cdd:cd17427 75 GLLCSLGMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 597 GWRLGLQIVAALTALSFFMGLMYRPASLYHPQRRaiqhlknqrkkmrekkpilsqdvestpkyfFLdisslksvtvkILL 676
Cdd:cd17427 155 GWRGSFLILGGLLLNCCVAGSLMRPLGPLFKHRG------------------------------FL-----------IYL 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 677 MTSSVASFGIYTPMFLMALNAAEQGSDVQELVLLQTFLGISMALGVVIAGallrrcfvirhFVINTKIV---TQLFLSIV 753
Cdd:cd17427 194 SGNVIMFLGFFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMG-----------LVANSKWIrprIQYFFSFA 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 754 AL----AILFLSFVMGYTGLCILSWLYGIGLGGFQYSLKILALERIKLKHFSKAWGFIRGVESVPVLISVPLTSFLNDYS 829
Cdd:cd17427 263 VMyngvCHLLCPLAEDYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVT 342
|
410
....*....|.
gi 1833085134 830 LKYgRAGYYIC 840
Cdd:cd17427 343 GNY-KYMYFVC 352
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
484-782 |
1.41e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 64.51 E-value: 1.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 484 LLGALSWSVSMVATSFVVSLCRKRSIRLLSIVGGLVMPLGILFTSFATEFGQVVFSYgIVFGVGVAMVREASTVMLGNYF 563
Cdd:COG2807 57 LLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGT-ALIGAGIAVGNVLLPGLIKRWF 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 564 KRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAGWRLGLQIVAALTALSFFmglmyrPASLYHPQRRAIQHLKNQRKKMR 643
Cdd:COG2807 136 PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALL------LWLPLLRRRPAAAAAAPAAASLR 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 644 ekkpilsqdvestpkyffldiSSLKSVTVKILLMTSSVASFGIYTPMFLMALNAAEQGSDVQELVLLQTFLGISMALGVV 723
Cdd:COG2807 210 ---------------------SLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSL 268
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1833085134 724 IAGALLRRCFVIRHFvintkivtqLFLSIVALAILFLSFVMGYTGLCILsW--LYGIGLGG 782
Cdd:COG2807 269 LVPLLADRLGDRRPL---------LLLLGLLGLAGLLGLLLAPGSLPWL-WavLLGLGQGG 319
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
442-618 |
9.64e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 58.72 E-value: 9.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 442 GWGWI------ICGVSFLVHILTTGLQLS-------YGLLWFYAVQYLHNTSGIELLGA----LSWSVSMVATSFVVS-L 503
Cdd:cd17321 148 GWRWIflinvpIGLVALLLARTFSGAVLAafllgaaLGGLLFLLPLYLQGVLGYSPLQAglalLPLALAMLVAAPLAGrL 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 504 CRKRSIRLLSIVGGLVMPLGILFTSF---ATEFGQVVFSYgIVFGVGVAMVREASTVMLGNYFKRRRQ-----FVEMVAM 575
Cdd:cd17321 228 ADRFGPRLVLVAGLLLTAVGLLLLALlgaDSSVWLLLPGL-VLLGLGLGLFATPLTNAALSSVPKEKAgaasgILNTARQ 306
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1833085134 576 SGEGVGIALFSVILKEGVGK-------------------AGWRLGLQIVAALTALSFFMGLM 618
Cdd:cd17321 307 LGGALGVALLGALLTAGLSAnlgdsgvaallsaaaaafaAGFHLAFLVAAALALLAALLALL 368
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
445-621 |
1.18e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 58.34 E-value: 1.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 445 WIICGVSFLVHILTTGLqlsygllWFYAVQYLHNTSGIELLGALSWSVSMVATSFVVSLC-------RKRSIRLLSIVGG 517
Cdd:COG2271 183 WLLALAYFLVYFALYGF-------LTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLggwlsdrLGRRRKLVLAIGL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 518 LVMPLGILFTSFATEFGqVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQ-----FVEMVAMSGEGVGIALFSVILkeg 592
Cdd:COG2271 256 LLAALALLLLALLPSPA-LAIALLFLAGFGLGGAFGLLWALAAELFPKKARgtasgLVNTFGFLGGALGPLLVGYLL--- 331
|
170 180
....*....|....*....|....*....
gi 1833085134 593 vGKAGWRLGLQIVAALTALSFFMGLMYRP 621
Cdd:COG2271 332 -DATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
443-781 |
5.72e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 56.40 E-value: 5.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 443 WGWIICGVSFLVHILTTGLQLSYGLLwfyavqylhntSGIELLGALSWSVSMVATSFVVslcRKRSIRLLSIVGGLVMPL 522
Cdd:COG0738 20 WGFATALWGPLIPALKDAFGLSDAQA-----------GLLLFAFFLGYLLASLPAGRLI---DRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 523 GILFTSFATEFGQVVFSYgIVFGVGVAMVREASTVMLGNYFKRRR-------QFVEMVAMSgegVGIALFSVILKEGVGk 595
Cdd:COG0738 86 GLLLFALAPSYPLLLLAL-FLLGLGLGLLDVAANPYVAALGPETAasrlnllHAFFSLGAL---LGPLLGGLLILLGLS- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 596 AGWRLGLQIVAALTALSFFMGLmyrpaslyhpqrraiqhlknqRKKMREKKPILSQDVESTPKYFFLdiSSLKSVTVKIL 675
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALLFL---------------------RSKLPEIEEEEEEAAGSAASLKSL--LKNPRLLLGGL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 676 LMTSSVA---SFGIYTPMFLMalnaAEQGSDVQELVLLQTFLGISMALGVVIAGALLRRCfvirhfvintKIVTQLFLSI 752
Cdd:COG0738 218 AIFLYVGaegAIGDWLPLYLK----DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF----------GPVRLLRLSA 283
|
330 340
....*....|....*....|....*....
gi 1833085134 753 VALAILFLSFVMGYTGLCILSWLYGIGLG 781
Cdd:COG0738 284 LLAAVGLLLALLAPGPWLALIGLALVGLG 312
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
486-794 |
1.26e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 55.25 E-value: 1.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 486 GALSWSVS------MVATSFVVSLCRKRSIRLLSIVGGLVMPLGILFTSFATEFGQVV-------FSYGIVFGVGVAMVR 552
Cdd:cd17324 34 AQAGLLVSayalgyALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLlaralagLAHGGFWAIAAAYAA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 553 EASTvmlgnyfKRRRQFVEMVAMSGEGVGIALfSVILKEGVGKA-GWRLGLQIVAALTALSFFMGLMYRPASLyHPQRRA 631
Cdd:cd17324 114 DLVP-------PEKRGRAIGLVFSGLTLGLVL-GRPLGGLLGQLlGWRAAFLAIAVLALLAALLLWRLLPSLP-PKKPGS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 632 IQHLKNQRKKMREKKPILSqdvestpkyFFLdisslksvtvkILLMTSSVasFGIYT--PMFLMALnaaeQGSDVQELVL 709
Cdd:cd17324 185 LGLLSSLLLLLRNPRLRLA---------YLI-----------TFLLFGGF--FALYTylAPFLTDV----PGFSSSAIIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 710 LQTFLGISMALGVVIAGALLRRcfvirhFVINTKIVTQLFLSIVALAILFLSFVMGytGLCILSWLYGIGLGGFQYSLKI 789
Cdd:cd17324 239 LLLLFGVAGVVGSPLAGRLADR------GGRRALLIALLLLAAALLLLTLLGPSPL--LLLVGLVLWGLGFFAAHSALQT 310
|
....*
gi 1833085134 790 LALER 794
Cdd:cd17324 311 RVLRL 315
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
665-828 |
4.52e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 53.44 E-value: 4.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 665 SSLKSVTVKILLMTSSVASFGIYTPMFLMALNAAEQGSDVQELVLLQTFLGISMALGVVIAGALLRRcfvirhfvINTKI 744
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR--------FGRRR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 745 VTQLFLSIVALAILFLSFVMGYTGLCILSWLYGIGLGGFQYSLKILALERIKLKHFSKAWGFIRGVESVPVLISVPLTSF 824
Cdd:COG2814 77 VLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156
|
....
gi 1833085134 825 LNDY 828
Cdd:COG2814 157 LADL 160
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
682-784 |
7.40e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 52.93 E-value: 7.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 682 ASFGIYTPMFLMALNAaeqgSDVQeLVLLQTFLGISMALGVVIAGALLRRcfvirhfvINTKIVTQLFLSIVALAILFLS 761
Cdd:COG0738 25 ALWGPLIPALKDAFGL----SDAQ-AGLLLFAFFLGYLLASLPAGRLIDR--------FGYKRGLLLGLLLMALGLLLFA 91
|
90 100
....*....|....*....|...
gi 1833085134 762 FVMGYTGLCILSWLYGIGLGGFQ 784
Cdd:COG0738 92 LAPSYPLLLLALFLLGLGLGLLD 114
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
453-783 |
1.00e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 52.17 E-value: 1.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 453 LVHILTTGLQLSYGLLWFYAVQYLHNTSGieLLGALSwSVSMVATS----FVVSLCRKRSIRLLSIVGGLVMPLGILFTS 528
Cdd:cd17478 3 LGHFLNDFYQGFLPALLPLLIAKLGLSYA--QAGLLV-SVFSITSSllqpLFGYLADRKPRRYLLPLGPLLTGLGLSLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 529 FATEFGQVVFSYGIVfGVGVAMVREASTVMLGNYFKRRRQFvemvAMS----GEGVGIALFSVIlkegvgkAGWRLGLQI 604
Cdd:cd17478 80 FAPNYWLLLLLVALA-GIGSAAFHPEGARLASQAAGGRRGL----AMSifsvGGNLGFALGPLI-------AAALVALFG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 605 VAALTALSFFMGLMYrpASLYHPQRRAIQHLKNQRKKMREKKPilsqdvestpkYFFLDISSLKSVTVKILLMTSSVASF 684
Cdd:cd17478 148 GLGLLILLIIPGLAV--ALLLLRLRPLKKPEAKKAAAKSSARS-----------TLKGVWRALLLLLIIVFLRSWVLSSL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 685 GIYTPMFLMalnaaEQGSDVQEL-VLLQTFLGISmALGVVIAGALLRRcfvirhfvINTKIVtqLFLSIVALAILFLSFV 763
Cdd:cd17478 215 TTFLPFYLV-----QRGYSLVFAgLLLSLFLFAG-AIGTLIGGPLSDR--------FGRRRV--IIASLLLAAPFLLLFL 278
|
330 340
....*....|....*....|
gi 1833085134 764 mgYTGLcILSWLyGIGLGGF 783
Cdd:cd17478 279 --LTPG-IWSYI-LLVLAGF 294
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
445-615 |
1.28e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 52.04 E-value: 1.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 445 WIICGVSFLVhilttglQLSYGLLWFYAVQYLHNTSGI-ELLGALSWSVSMVATSFVVSLC-----RKRSIRLLSIVGGL 518
Cdd:cd06174 206 WLLLLAIFLV-------NLAYYSFSTLLPLFLLDLGGLsVAVAGLLLSLFGLAGALGSLLLgllsdRLIGRKPLLLIGLL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 519 VMPLGILFTSFATeFGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQ-----FVEMVAMSGEGVGIALFSVILkegV 593
Cdd:cd06174 279 LMALGLALLLLAP-SLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRgtafgLLNTFGFLGGAIGPLLAGFLL---A 354
|
170 180
....*....|....*....|..
gi 1833085134 594 GKAGWRLGLQIVAALTALSFFM 615
Cdd:cd06174 355 ATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
466-795 |
1.62e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.85 E-value: 1.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 466 GLLWFyAVQYLHNTSGIELLGALSWSVSMVATSFVVSLCRKRSIRLLSIVGGLVM--PLGILFTSFATEFGQVVFSYGIV 543
Cdd:cd06173 21 ALPWL-VLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRalLAAVLALLALLGSLSLWLLLVLA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 544 FGVGVAM-----VREASTVML--GNYFKRRRQFVEMVAMSGEGVGIALFSVILkegvgkaGWrLGLQIVAALTALSFFMG 616
Cdd:cd06173 100 FLLGIASaffgpARQALLPELvpKEQLVRANALNSLATQLARIIGPALGGLLV-------AL-LGPGGAFAINALSFLLS 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 617 LmyrpASLyhpqrRAIQHLKNQRKkmREKKPILSQDVESTPKYFFldisslKSVTVKILLMTSSVASFGIYTPMFLMALN 696
Cdd:cd06173 172 A----LLL-----LFIRRPPPAAP--GESSSLLLRDLREGLRYLR------RSPLLRLLLLALALFALLGGALTVLLPLL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 697 AAEQ-GSDVQELVLLQTFLGISMALGVVIAGALLRRcfvirhfvINTKIVTQLFLSIVALAILFLSFVMGYTGLCILSWL 775
Cdd:cd06173 235 AKEVlGGGAAGYGLLLAAFGVGALLGALLLGRLSKR--------RRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFL 306
|
330 340
....*....|....*....|
gi 1833085134 776 YGIGLGGFQYSLKILALERI 795
Cdd:cd06173 307 LGLAGGLFNVPLNTLLQLRV 326
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
449-787 |
4.61e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 50.31 E-value: 4.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 449 GVSFLVHILTTGLQLSYGLLWFyavqylhntsgieLLGALSW--SVSMVATSFVVSlcrKRSIRLLSIVGGLVMPLGILF 526
Cdd:cd17475 14 GIPALAPFLQEDLHLSLAQVGL-------------LLSALNLgvAVSMLPAGWLLD---RFGERRVLAVGLLLMGAAALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 527 TSFATEFGqVVFSYGIVFGVGVAMVREASTVMLGNYF-KRRRQFvemvAMS----GEGVGIALFSVILKEGVGKAGWRLG 601
Cdd:cd17475 78 MALVGSYP-VLLVLLFLVGAGYGSVQPGGGRAIMRWFpPRERGL----AMGirqtGVPLGGALAAALLPPLALHYGWRAA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 602 LqivAALTALSFFMGLMYrpASLYHPQRRAIQHLKNQRKKMREKKPILSQdvestpkyffldiSSLKSVTVKILLMTSSV 681
Cdd:cd17475 153 F---VVAGLVSILAAVLF--WLFYREPPAASAATESASTLLRSLKEVLRN-------------RDVWLIAIAGALLVAPQ 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 682 ASFGIYTPMFlmalnaaeqgsdvqelvlLQTFLGISMALG------VVIAGALLRRCF-VI--RHFVINTKIVTQLFLSI 752
Cdd:cd17475 215 FALLTFLLLF------------------LHDHLGLSVVAAgallavAQLGGALGRIGLgRVsdRVFGGRRRPVLVITAAI 276
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1833085134 753 VALAILFLSFVMGYT------GLCILSWLYGIGLGGFQYSL 787
Cdd:cd17475 277 AAAALLVLSLLSPGTplwllvLLLILLGLFAIGWNGLYLTL 317
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
460-784 |
3.26e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.97 E-value: 3.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 460 GLQLSYGLLWFYAVQYLHNTSGI--ELLGALsWSVSMVATSFV------VS------LCRKRS-IRLLSIVGGLVMPLgi 524
Cdd:COG2211 21 GLNLAFGLLSAYLLYFYTDVLGLsaALVGLI-LLVARLWDAITdpligaLSdrtrtrWGRRRPwILIGAIPLALSFVL-- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 525 LFTSFA-TEFGQVVFSYG--IVFGVGVAMVREA----STVMLGNYFKRRR--QFVEMVAMSGEGVGIALFSVILKEGVGK 595
Cdd:COG2211 98 LFTAPDlSPTGKLIYALVtyLLLGLAYTLVNIPysalGAELTPDYEERTRlsSWRFAFAGLGGLLASVLPPPLVAAFGGD 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 596 A--GWRLGLQIVAALTALSFFmgLMYRpaslyhpqrraiqhlknqrkKMREKKPilsqdVESTPKYFFLDISSLKS---- 669
Cdd:COG2211 178 AalGYRLTALIFAVLGLLAFL--LTFF--------------------GTKERPV-----PEEEKVSLKESLKALLKnrpf 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 670 ---VTVKILLMTSSVASFGIYTPMFLMALnaaeqGSDVQELVLLQTFLGISMALGVVIAGALLRRcfvirhfvINTKIVT 746
Cdd:COG2211 231 lllLLAYLLFFLALALVAALLLYYFKYVL-----GLSAALVGLLLALYFLAALLGAPLWPRLAKR--------FGKKKAF 297
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1833085134 747 Q--LFLSIVALAILFLSFVMGYTGLCILSWLYGIGLGGFQ 784
Cdd:COG2211 298 IigLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAIL 337
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
674-839 |
3.34e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.56 E-value: 3.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 674 ILLMTSSVASFGIYTPMFLMALNAAEQGSDVQELVLLQTFLGISMALGVVIAGALLRRcfvirhfvINTKIVTQLFLSIV 753
Cdd:COG2271 14 LLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADR--------FGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 754 ALAILFLSFVMGYTGLCILSWLYGIGLGGFQYS-LKILAlERIKLKHFSKAWGFIRGVESVPVLISVPLTSFLNDYslkY 832
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAaLKLIA-EWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA---F 161
|
....*...
gi 1833085134 833 G-RAGYYI 839
Cdd:COG2271 162 GwRAAFLI 169
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
445-625 |
5.32e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.20 E-value: 5.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 445 WIICGVSFLVhilTTGLQLSYGLLWFYAVQYLHNTSGIELLGALSWSVSMVATSFVVS-----LCRKRSIRLLSIVGGLV 519
Cdd:COG2211 231 LLLLLAYLLF---FLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPrlakrFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 520 MpLGILFTSFATEFGQVV------FSYGIVFGVGVAMVreASTVMLGNYFKRRRQ---------FVEMVAMsgeGVGIAL 584
Cdd:COG2211 308 L-LLLFFLGPGNLWLLLVlaalagIGLGAILVLPWAML--ADVVDYDEWKTGRRReglyfgiftFAIKLGQ---ALAGAL 381
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1833085134 585 FSVILkegvGKAGWRLGL-QIVAALTALSFFMGLMyrPASLY 625
Cdd:COG2211 382 AGLLL----ALFGYVAGAaQSPSALTGIRLLFFLL--PAVLL 417
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
505-793 |
7.49e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.44 E-value: 7.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 505 RKRSIrLLSIvggLVMPLGILFTSFATEFGQVVFSYGIV-FGVGVAMVrEASTVMLGNYFKRRRQFVEMVAMSGEGVGI- 582
Cdd:cd17316 65 RKKAL-ILTL---LLFGLATLLIGLLPTPILLLVLRFLQgIGIGGEYP-GASTYVAEFAPSKRRGFALGLLQSGWALGAl 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 583 --ALFSVILKEGVGKA-GWRLGLqIVAALTALsffMGLMYRPASLyhpqrraiqhlknqrkkmrekkpilsqdvestpky 659
Cdd:cd17316 140 laALVASLLIPLLSGDwGWRILF-LIGALPAL---LALLLRRRTL----------------------------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 660 ffldisslksvtvkILLMTSSVASFGIYT-PMFLMALNAAEQGSDVQELVLLQTFLGISMALGVVIAGALLRRcfVIRHF 738
Cdd:cd17316 181 --------------LLILLWFFISFGYYGlTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR--IGRKK 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1833085134 739 VintkIVTQLFLSIVALAILFLSFVMGYTGLCILSWLYGIGLGGFQYSLKILALE 793
Cdd:cd17316 245 T----LVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAE 295
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
511-781 |
1.17e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 45.64 E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 511 LLSIVGGlVMPLgilftsFATEFGQVVFSYgIVFGVGVAMVREASTVMLGNYF--KRRRQFVEMVAMSGEGVGIALFSVI 588
Cdd:cd17473 73 LLYGIGG-VAGL------FLDSLYALLASR-ALLGIGVAGIMTLATALIGDYFegEERAKMLGLQSAAMSLGGVVFLLLG 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 589 lkEGVGKAGWRL-----GLQIVAALTALSFfmglmyrpasLYHPQRRAIQHlKNQRKKMREKKPILSqdvestpkyffld 663
Cdd:cd17473 145 --GALAEIGWRApflvyLLALPVLILVLLF----------LPEPARKSKSA-ASPGAATAAALPWKR------------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 664 isslksvtVKILLMTSSVASFGIYTPMFLMALnaaeqgsdvqelvLLQTFLGIS----------MALGVVIAGALLRRcf 733
Cdd:cd17473 199 --------VLPIYFLAFLAMLLFYVIPIQLPF-------------LLQERGGGSaaliglalaiASLAGAIGALLFGR-- 255
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1833085134 734 VIRHfvINTKIVTQLFLSIVALAILFLSFVMGYTGLCILSWLYGIGLG 781
Cdd:cd17473 256 LKRR--LGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFG 301
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
450-825 |
1.38e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.78 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 450 VSFLVHILTTGLqlsYGLLWFYAVQYLH-NTSGIELL------GALSwsVSMVATSFVVSLCRKRSIrllsIVGGLVMPL 522
Cdd:cd17333 3 ISFFSNGLTDAL---LGILGPSLEEAFNlNVADVSVIfssqnaGYLI--GSLLAGFLMKRLGRRRTL----ILGLLLISL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 523 ---GILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEGVGkagWR 599
Cdd:cd17333 74 alaLIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELS---WS 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 600 LGLQIVAaLTALSFFMGLMyRPASLYHPQRRaiQHLKNQRKKMREKKPILSQdvestPKYFFLDISslksvtvkILLMTS 679
Cdd:cd17333 151 WAYLIIG-LIYLLLAILIL-LTLFPELPSAR--NPQQSVGAFSASASRLLRN-----PSIILGALA--------LFLYVG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 680 SVASFGIYTPMFLMAlnaaEQGSDVQELVLLQTFLGISMALGVVIAGALLRRcfvirhfvinTKIVTQLFLSIV-ALAIL 758
Cdd:cd17333 214 AETAFSSWVPSYLVE----KKHVSDGLAGYLLSGFWVGITIGRLLGGPISRR----------IKPHTLLVLSGSgALLGL 279
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1833085134 759 F-LSFVMGYTGLCILSWLYGIGLGGFQYSLKILALERIKLKHfSKAWGFIRGVESVPVLISVPLTSFL 825
Cdd:cd17333 280 LiLLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAK-GKGTSVLLAAGSIGGAIIPFIMGFI 346
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
489-783 |
1.55e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 45.43 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 489 SWSVSMVATSFVVS---------------LCRKRSIRLLSIVGGLVMPLGILFTSFATEFGQVVFsYGIVFGVGVAMVRE 553
Cdd:TIGR00895 46 EWGLDPVQLGFLFSagligmafgalffgpLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLI-LRFLAGLGLGGLMP 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 554 ASTVMLGNYF-KRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAGWRLGLQIVAALTALSFFMGLMYRPASLYHPQRRAI 632
Cdd:TIGR00895 125 NLNALVSEYApKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRP 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 633 QHLKNQRKKMREKKPILSQDVESTPKYF-----------FLDISSLKSVtvkILLMTSSVASFGIYTPMFLMALNAAEQG 701
Cdd:TIGR00895 205 ETVRRIVNAIAPQMQAEAQSALPEQKSTqgtkrsvfkalFQGKTARITV---LLWLLYFMLLVGVYFLTNWLPKLMVELG 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 702 SDVQELVLLQTFLGISMALGVVIAGALLRRcfvirhfvINTKIVTQLFLSIVALAIL----FLSFVMGYTGLCILSWLYG 777
Cdd:TIGR00895 282 FSLSLAATGGALFNFGGVIGSIIFGWLADR--------LGPRVTALLLLLGAVFAVLvgstLFSPTLLLLLGAIAGFFVN 353
|
....*.
gi 1833085134 778 IGLGGF 783
Cdd:TIGR00895 354 GGQSGL 359
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
510-793 |
2.44e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 44.88 E-value: 2.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 510 RLLSIVGGLVMpLGILFTSFATEFGQVVFSYGI------VFGVGVAMVREastvmlgnYFKRRRQFVE---MVAMSGEGV 580
Cdd:cd17504 62 KVLLIVLAIYT-AGSLLAAFAPNLPVLIAGRALqgiggaVFPLAFALVRE--------EFPPERVPVAqgiLSATFGIGA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 581 GIALF--SVIlkegVGKAGWRLGLQIVAALTALSFFMglmyrpaslyhpqrraiqhlknqrkkmrekkpilsqdvesTPk 658
Cdd:cd17504 133 GIGLPlgGWI----VQHLGWRWIFWTAAPVAVLLAAL----------------------------------------VP- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 659 yfFLDISSLKSVTVKILLMTSSVASFGIYT-----PMFLMALNAAEQGSDVQELVLLQTFLGISMALGVVIAGALLRRcf 733
Cdd:cd17504 168 --LIDLRLLRRRNVLLANITALLAGFGMFMvfqllPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIAR-- 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1833085134 734 virhfvINTKIVTQLFLSIVALAILFLSFVMGYTGLCILSW-LYGIGLGGFQYSLKILALE 793
Cdd:cd17504 244 ------VGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALlLIGIGLGLAFASLPNIVVE 298
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
497-782 |
3.46e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 44.53 E-value: 3.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 497 TSFVVSLCrkrsirLLSIVGG---------LVMPLGILF-------TSFATEFGQVVFSYGIVfGVGVAMVREASTVMLG 560
Cdd:cd17328 41 TVFIISYM------VLSPIFGylgdrynrkWILAVGILIwsaatllSSFAPNFWQLLLFRALV-GIGEASYSPIAPTIIA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 561 NYFKR-RRQFVEMV-AMS---GEGVGIALFSVILKEGvgkAGWRLGLQIVAALTAL-SFFMGLMYRPaslyhPQRRAIQH 634
Cdd:cd17328 114 DLFPKeKRTRALGVfYFAiplGSGLGYVVGGLVAQAT---GGWRWAFRVTGVLGVLlAILLLLFVRE-----PPRGAAEG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 635 LKNQRKKMREKKPILSQdVESTPKYFfldISSLKSVTVkillmTSSVASFGIYTPMFLM-ALNAAEQGSDVQELVllqtF 713
Cdd:cd17328 186 GVMAKSTATSFLADLKA-LAKNPSFI---LSTLGFTAV-----SFVTGALAFWAPTFFLrAFGVGDLSSADVGLI----F 252
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1833085134 714 LGISMA---LGVVIAGALLRRCfviRHFVINTKIVTQLFLSIVALAILFLSFVMGYTGlciLSWLYGIGLGG 782
Cdd:cd17328 253 GAITCIagvLGVLLGGILADRL---RRKTPRADPLVCAVGLLAAAPFLFLALVLALSN---LLLAWVLLFLG 318
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
453-779 |
3.49e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.14 E-value: 3.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 453 LVHILTTGLQLSYGLLWFYAVQYLHNtsgiellgALSWSVSMV--------ATSFVVSLC---------RKRSIrllsIV 515
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWPFMAIYLHQ--------QLGLSASIVglvlalsaVAGIVASLIggrladrfgRKPVM----LA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 516 GGLVMPLGILFTSFATEFGQVVFSYgIVFGVGVAMVREASTVMLGNYFK-RRRQFVEMVAMSGEGVGIALFSVIlkegvg 594
Cdd:cd17329 71 GLLLRALGFALLGFAHSPWLFAIAL-VLTGFGGGLFEPASEAMIADVTTpENRTRAFSLLYWAINLGVAIGPLL------ 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 595 kAGW--RLGLQIVAALTALSFFMGLMyrpASLYHPQRRAIQHLKNQRKKMREKKPILSQDvestpKYFFLdisslksVTV 672
Cdd:cd17329 144 -GGLllLYSFRLLFLAAAVLFLLAAL---VLLFLLPETRPKRRAAEKTEILRGYKIVLRD-----RAFLL-------FLL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 673 KILLMTSSVASFGIYTPMFLmalnaaeqgsdVQELVLLQTFLGISMAL-GVVIAGALlrrcFVIRHFVINTKIVTQLFLS 751
Cdd:cd17329 208 ASFLISLIYFQLESTLPVYV-----------VEILGLGESLLGLLLALnALLIVLLQ----FPVARLVERFRLRKILMIG 272
|
330 340 350
....*....|....*....|....*....|
gi 1833085134 752 IV--ALAILFLSFVMGYTGLCILSWLYGIG 779
Cdd:cd17329 273 ILlfAIGFAVLAFANTLAVLILAMIVLTLG 302
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
483-819 |
4.01e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 4.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 483 ELLGALSWSVSMVATSFVV----------SLCRKRSIRLLSIVGGLVMPLGILFTSFATEFGQVVFSYgIVFGVGVAMVR 552
Cdd:cd17474 27 EALGASPAQVGLLITAFTLpaavlmpvagVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGR-ALQGIGAAGLG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 553 EASTVMLGNYFK-RRRQFVEMVAMSGEGVGIALFSVIlkeG--VGKAGWR-----LGLQIVAALTALSFFMglmyrpasl 624
Cdd:cd17474 106 PLALTLIGDLFEgGERAKAMGLYEAALGLGIAVGPLL---GglLAAISWRypfflLAALIPVAFLAILFLL--------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 625 yhpqrraiqhlknqrKKMREKKPILSQDVESTPKYFFLDISSLKSVTVKILLMtssVASFGI--YTPMFLmalnAAEQGS 702
Cdd:cd17474 174 ---------------PEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYF---FLYFAFltYLPFLL----ELLYGI 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 703 DVQELVLLQTFLGISMALGVVIAGALLRRCFVIRHFvintkivtqLFLSIVALAILF--LSFVMGYTGLCILSWLYGIGL 780
Cdd:cd17474 232 SPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRI---------LVIGLLLYALSLllLGFVPSLALLLIAIVLFGLGL 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1833085134 781 GGFQYSLKILALERIKLKH---FSKAWGFIR--GVESVPVLISV 819
Cdd:cd17474 303 GLNLPLLTTLVTELAPEEErgtASSLYNFVRflGQAVGPLLFGL 346
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
683-783 |
5.84e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.70 E-value: 5.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 683 SFGIYTPmfLMALNAAEQGSDVQELVLLQTFLGISMALGVVIAGALLRRCFVIRHFVintkivtqLFLSIVALAILFLSF 762
Cdd:cd17477 11 GSGLLLP--LLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFA--------AGAAITAVSVLLLAL 80
|
90 100
....*....|....*....|.
gi 1833085134 763 VMGYTGLCILSWLYGIGLGGF 783
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGL 101
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
505-757 |
6.41e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 43.26 E-value: 6.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 505 RKRSIrllsIVGGLVMPLGILFTSFATEFGQVVFSYgIVFGVGVAMVREASTVMLGNYF-KRRRQFVEMVAMSGEGVGIA 583
Cdd:COG0477 78 RKRVL----LIGLLLFGLASLLCGLAPSPELLIAAR-ALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLA 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 584 ---LFSVILkegVGKAGWRLGLQIVAALTALSFFMglmyrpaslyhpqrraiqhlknqRKKMREKKPILSQDVESTPKYF 660
Cdd:COG0477 153 lgpLLGGLL---VAALGWRWIFLINAPLGLLALVL-----------------------RLRLPESRGLLLALLALALAAL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 661 FLDISSLKSVTVKILLMTSSVASFGIYTPMFLMALNAAeqgsdvqeLVLLQTFLGISMALGVVIAGALLRRCFVIRHFVI 740
Cdd:COG0477 207 LLAALALALLALLLLLLLLLLALLALLLAGAALLLLLA--------LLLLALLLLLALLLLAALLLLLLLLLLLALLLAL 278
|
250
....*....|....*..
gi 1833085134 741 NTKIVTQLFLSIVALAI 757
Cdd:COG0477 279 LLLLLLLLLLLLLALLL 295
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
661-792 |
1.13e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.56 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 661 FLDISSLKSVTVKILLMTSSVASFGIYTPMFLMAL--------NAAEQGsdvqeLVLLqtFLGISMALGVVIAGALLRRc 732
Cdd:cd17503 169 LLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLylqnvlgySAFESG-----LVLA--PGGLASAILSPLVGRLLDK- 240
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1833085134 733 fvirhfvINTKIVTQLFLSIVALAILFLSFVMGYTGLCILSWLY---GIGLGGFQYSLKILAL 792
Cdd:cd17503 241 -------FGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLfirGLGMGLVFMPLNTLAL 296
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
484-618 |
1.55e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 42.17 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 484 LLGALSwsVSMVATSFVVSLC--RKRSIRLLSIVGGLVMPLGILFTSFATEFGQVVFSygIVFGVGVAMVREASTVMLGN 561
Cdd:COG2807 255 LLSLFQ--LAGIPGSLLVPLLadRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWA--VLLGLGQGGLFPLALTLIGL 330
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1833085134 562 YFKRRRQFVEMVAMSgEGVGIALFSV------ILKEGVGkaGWRLGLQIVAALTALSFFMGLM 618
Cdd:COG2807 331 RARTPAEAAALSGMA-QSVGYLLAALgpllvgALHDATG--SWTAALLLLAALAVLMLVAGLL 390
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
740-825 |
1.57e-03 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 42.21 E-value: 1.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 740 INTKIVTQLFLSIVALAILFLSFVMGYTGLCILSWLYGIGLGGFQYSLKILALERIKLKHFSKAWGFIRGVESVPVLISV 819
Cdd:PRK10213 82 TDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAA 161
|
....*.
gi 1833085134 820 PLTSFL 825
Cdd:PRK10213 162 PLGSFL 167
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
510-648 |
2.68e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 41.84 E-value: 2.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 510 RLLSIVGGLVMPLGILFTSFATEFGQVVFSyGIVFGVGvamvreASTVMLGNYF------KRRRQFVEMVAMSGEGVGIA 583
Cdd:cd06179 62 RWFFIGGNLLGVVGSIVAGTAKSVNMLIGG-QALIGIG------AGTQGLGAAVaselvpNKYRGLVQGVVNLVASPGSA 134
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1833085134 584 LFSVI----LKEGVgkAGWRLGLQIVAALTALSFFmGLMYrpasLYHPQRRAIQHLKNQRKKMREKKPI 648
Cdd:cd06179 135 LGPLIagalVEANA--AGWRWIFYINAIFNALALI-LLFF----FYHPPPRPQLHGSSTRQKLKRLDWV 196
|
|
| YoaK |
COG3619 |
Uncharacterized membrane protein YoaK, UPF0700 family [Function unknown]; |
511-617 |
3.23e-03 |
|
Uncharacterized membrane protein YoaK, UPF0700 family [Function unknown];
Pssm-ID: 442837 Cd Length: 228 Bit Score: 40.29 E-value: 3.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 511 LLSIVGGLV-----MPLGILFTSFAT-------------EFGQVVFSYGIV--FGVGVAmvreASTVMLgNYFKRRRQFV 570
Cdd:COG3619 20 LLAFVAGFVdavgfLALGGVFTSHMTgnvvllgialaggDWAGALLALLAIlaFVLGAA----LSGLLI-RRARRRLRRW 94
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1833085134 571 EMVAMSGEGVGIALFSVilkegvgkagWRLGLQIVAALTALSFFMGL 617
Cdd:COG3619 95 YALLLLLEAVLLLLAGL----------LGLSLPDLLAVLLLAFAMGL 131
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
447-794 |
4.45e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.66 E-value: 4.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 447 ICGVSFLVhILTTGLQLSygLLWFYAVQYLHNTSGIELLGALSWSVSMVATSFVVSLCRKRSIRLLSIVGGLVMPLGILF 526
Cdd:cd17489 1 ILLANFFF-FLSFYLLLP--VLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 527 TSFATEFGQVVFSYgIVFGVGVAMVREASTVMLGNYFKRRRqFVEMVAMSGEGVGI--ALFSVIlkeGVGKAGWrLGLQ- 603
Cdd:cd17489 78 YLLATSVALLLVLR-LIHGIGWGAFTTAAATLVADIIPPSR-RGEGIGYYGLATTLamALGPAL---GLFLYQH-LGFAv 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 604 --IVAALTALSFFMGLMYRPASlYHPQRRAIQHLKNQRKKMREKKPILsqdvestpkyffldisslksVTVKILLMTSSV 681
Cdd:cd17489 152 lfIVAAVLALLALLLVFLVKDP-PPVAAEEAEAGTRAFRRLVEKKVLP--------------------PALILFLASIAY 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 682 ASFGIYTPMFLMALNAAEQGsdvqelvllqTFLGIsMALGVVIAGALLRRcFVIRHfviNTKIVTQLFLSIVALAILFLS 761
Cdd:cd17489 211 GAISTFLPLYAAERGISNAG----------LFFTV-YAIALLLSRPFSGK-LSDRK---GPKTVIIPGLLLLALGLLLLS 275
|
330 340 350
....*....|....*....|....*....|...
gi 1833085134 762 FVMGYTGLCILSWLYGIGLGGFQYSLKILALER 794
Cdd:cd17489 276 FAGSPWMLLLAAVLYGLGFGLLFPALQALAVDL 308
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
488-778 |
6.59e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 40.37 E-value: 6.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 488 LSWSV---SMVATS----------FVVSLCRKRSIRLLSIVGGLVMPLGILFTSFATEFGQVVFSYGIVfGVGVAMVREA 554
Cdd:cd06180 29 LGLSYaqaGWIATAnyagylvgalLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLA-GAASAFVFVF 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 555 -STVMLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEGVGKA-GWRlglQIVAALTALSFFMGLMYRPASLYHPQRRAI 632
Cdd:cd06180 108 gSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGlSWR---AGWLALALLSAVLLLLSFLLLRRGPSAPTE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 633 QHLKNQRkkmrekkpilsqdvestpkyffldisSLKSVTVKILLMTSSVASFGIYTPMFLMALNAAEQGSDVQELVLLQT 712
Cdd:cd06180 185 ASAAESA--------------------------PGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWS 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1833085134 713 FLGISMALGVVIAGALLRRCFVIRHFVINtkivtqlfLSIVALAILfLSFVM-GYTGLCILSWLYGI 778
Cdd:cd06180 239 LFGLAAVPSCFLWGALSDRWGTRRALAAN--------LLVQAVGVL-LPLLSpGPAGLVLSAVLFGG 296
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
690-825 |
6.99e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 40.36 E-value: 6.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 690 MFLMALNA--AEQGSDVQELVLLQTFLGISMALGVVIAGALLRRcfvirhfVINTKIVTqlfLSIV--ALAILFLSFVMG 765
Cdd:cd17371 17 LLGLVLPAliAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADR-------FGRVRVLV---ITILlfAVFTLLCGFAQN 86
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 766 YTGLCILSWLYGIGLGGFQYSLKILALERIKLKHFSKAWGFIRGVESVPVLISVPLTSFL 825
Cdd:cd17371 87 YWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALL 146
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
441-617 |
7.22e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 39.94 E-value: 7.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 441 GGWGW------IICGVSFLVHIL-----TTGLQLSYGLLW-------FYAVQYLHNTSGIELLGALSW----SVSMVATS 498
Cdd:cd17476 150 AWWPWifwflaILAAIVAVAAIFwtspsFIAVLLAVFLGWasfgiwvFYATQYFQNVRGYSPLLTSARfipmAIGGVLAA 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 499 FVVSLCRKRsirllsIVGGLVMPLGILFTSFATEF------GQVVFSYG----IVFGVGVAMVREASTVMLGNYFKRRRQ 568
Cdd:cd17476 230 ITVGFLIAR------LPPSYIMAISMVAFLVGPILfatmpvHQTYWAQAfpamIVAPFGMDFSFPAATIIASNAVPREYQ 303
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1833085134 569 ------FVEMVAMSGE-GVGIA---LFSVILKEGVGKAGWRLGLQIVAALTALSFFMGL 617
Cdd:cd17476 304 glagslVNTVVNYGISiGLGIAgtvETSVNEDGADLLKGYRAAWYLGIGLAALGLLISV 362
|
|
| RhaT |
COG0697 |
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ... |
420-619 |
7.62e-03 |
|
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];
Pssm-ID: 440461 [Multi-domain] Cd Length: 290 Bit Score: 39.83 E-value: 7.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 420 IPALRRTGVDTTRIRQyfypdGGWGWIIcGVSFLVHILttglqlsYGLLWFYAVQYLhnTSGielLGALSWSVSMVATSF 499
Cdd:COG0697 47 LPLLLLRGRRLPPLSR-----RDWLLLL-LRGLLGLAL-------AFLLFFLALQYT--PAA---LAALLLALAPLFVAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833085134 500 VVSLCRKRSIRLLSIVGGLVMPLGILFTSFATEFGQVVFSYGIVFGVGVAMVReASTVMLGNYFKRRRQFVEMVAMSGEG 579
Cdd:COG0697 109 LAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGGGGSLLGDLLALLAALSW-ALYTVLTRRLSRRLDPLTLTFWQMLV 187
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1833085134 580 VGIALFSVILkegVGKAGWRLGLQIVAALTALSFF-MGLMY 619
Cdd:COG0697 188 GALLLLPLAL---LTGLPLPLSAAAWLALLYLGLFgTALAY 225
|
|
| |
