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Conserved domains on  [gi|401712786|gb|AFP99126|]
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retinoic acid early transcript 1L, partial [Homo sapiens]

Protein Classification

MHC_I domain-containing protein( domain architecture ID 194)

major histocompatibility complex class I (MHC_I) domain-containing protein similar to Homo sapiens endothelial protein C receptor and retinoic acid early transcript 1L protein

CATH:  3.30.500.10
Gene Ontology:  GO:0006955

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MHC_I super family cl08246
Class I Histocompatibility antigen, domains alpha 1 and 2;
3-81 2.58e-08

Class I Histocompatibility antigen, domains alpha 1 and 2;


The actual alignment was detected with superfamily member pfam00129:

Pssm-ID: 471794  Cd Length: 179  Bit Score: 48.54  E-value: 2.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401712786    3 TLQARMSCEQKAEGHSS-GSWQFSIDGQTFLLFDSEKRMWTTVHPGARKMKEKWENDKDVAMSFHYISmGDCIGWLEDFL 81
Cdd:pfam00129  94 TLQWMYGCDVGPDGRLLrGYEQFAYDGKDYIALNEDLRSWTAADPAAQITKRKWEAAGEAERQRAYLE-GECVEWLRRYL 172
 
Name Accession Description Interval E-value
MHC_I pfam00129
Class I Histocompatibility antigen, domains alpha 1 and 2;
3-81 2.58e-08

Class I Histocompatibility antigen, domains alpha 1 and 2;


Pssm-ID: 395078  Cd Length: 179  Bit Score: 48.54  E-value: 2.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401712786    3 TLQARMSCEQKAEGHSS-GSWQFSIDGQTFLLFDSEKRMWTTVHPGARKMKEKWENDKDVAMSFHYISmGDCIGWLEDFL 81
Cdd:pfam00129  94 TLQWMYGCDVGPDGRLLrGYEQFAYDGKDYIALNEDLRSWTAADPAAQITKRKWEAAGEAERQRAYLE-GECVEWLRRYL 172
 
Name Accession Description Interval E-value
MHC_I pfam00129
Class I Histocompatibility antigen, domains alpha 1 and 2;
3-81 2.58e-08

Class I Histocompatibility antigen, domains alpha 1 and 2;


Pssm-ID: 395078  Cd Length: 179  Bit Score: 48.54  E-value: 2.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401712786    3 TLQARMSCEQKAEGHSS-GSWQFSIDGQTFLLFDSEKRMWTTVHPGARKMKEKWENDKDVAMSFHYISmGDCIGWLEDFL 81
Cdd:pfam00129  94 TLQWMYGCDVGPDGRLLrGYEQFAYDGKDYIALNEDLRSWTAADPAAQITKRKWEAAGEAERQRAYLE-GECVEWLRRYL 172
MHC_I_2 pfam14586
Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2; Members of this family are ...
 4-81 7.76e-05

Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2; Members of this family are known as retinoic-acid-inducible proteins. They are ligands for the activating immunoreceptor NKG2D, which is widely expressed on natural killer cells, T cells, and macrophages.


Pssm-ID: 291265  Cd Length: 174  Bit Score: 38.97  E-value: 7.76e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 401712786    4 LQARMSCEQKAEGHSSGSWQFSIDGQTFLLFDSEKRMWTTVHPGARKMKEKWENDKDVAMSFHYIsMGDCIGWLEDFL 81
Cdd:pfam14586  92 LQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTENMSWRSANDESGVIMNKWNDDGDLVQRLKYF-IPECRQKIDEFL 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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