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Conserved domains on  [gi|387019555|gb|AFJ51895|]
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Ubiquitin-associated protein 1-like [Crotalus adamanteus]

Protein Classification

UBA1_UBAP1 and UBA2_UBAP1_like domain-containing protein( domain architecture ID 10198572)

UBA1_UBAP1 and UBA2_UBAP1_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UBA1_UBAP1 cd14315
UBA1 domain found in vertebrate ubiquitin-associated protein 1 (UBAP-1); UBAP-1, also called ...
 386-428 7.60e-20

UBA1 domain found in vertebrate ubiquitin-associated protein 1 (UBAP-1); UBAP-1, also called nasopharyngeal carcinoma-associated gene 20 protein, is a ubiquitously expressed protein that may play an important role in the ubiquitin pathway and cell progression. It co-localizes with TDP-43 proteins in neuronal cytoplasmic inclusions and acts as a genetic risk factor for frontotemporal lobar degeneration (FTLD). Moreover, UBAP-1, together with VPS37A, forms an endosome-specific endosomal sorting complexes I required for transport (ESCRT-I) complex that displays a restricted cellular function, ubiquitin-dependent endosomal sorting and multivesicular body (MVB) biogenesis. UBAP-1 contains an N-terminal UBAP-1-MVB12-associated (UMA) domain, and two tandem ubiquitin-associated (UBA) domains that may be responsible for the binding of ubiquitin-conjugating enzymes. This model corresponds to UBA1 domain.


:

Pssm-ID: 270500  Cd Length: 43  Bit Score: 82.59  E-value: 7.60e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 387019555 386 LTSSEREYLEIVVGMGYSYEDVLKAMKRKGQSIDQILEYLVVR 428
Cdd:cd14315    1 LSPSERQCVETVVGMGYSYECVLKAMKKKGQNIEQILEYLFAH 43
UBA2_UBAP1_like cd14316
UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, ...
 459-494 4.08e-13

UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, also called nasopharyngeal carcinoma-associated gene 20 protein, is a ubiquitously expressed protein that may play an important role in the ubiquitin pathway and cell progression. It co-localizes with TDP-43 proteins in neuronal cytoplasmic inclusions and acts as a genetic risk factor for frontotemporal lobar degeneration (FTLD). Moreover, UBAP-1, together with VPS37A, forms an endosome-specific endosomal sorting complexes I required for transport (ESCRT-I) complex that displays a restricted cellular function, ubiquitin-dependent endosomal sorting and multivesicular body (MVB) biogenesis. UBAP-1 contains an N-terminal UBAP-1-MVB12-associated (UMA) domain, and two tandem ubiquitin-associated (UBA) domains that may be responsible for the binding of ubiquitin-conjugating enzymes. This model corresponds to UBA2 domain.


:

Pssm-ID: 270501  Cd Length: 37  Bit Score: 63.32  E-value: 4.08e-13
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 387019555 459 LQLMSKFQEMGFKLKDIKEALLLHNNDQDNALEDLM 494
Cdd:cd14316    2 LKLLNQLHELGFPEDKIKEALLKHNNDRDKALDELV 37
 
Name Accession Description Interval E-value
UBA1_UBAP1 cd14315
UBA1 domain found in vertebrate ubiquitin-associated protein 1 (UBAP-1); UBAP-1, also called ...
 386-428 7.60e-20

UBA1 domain found in vertebrate ubiquitin-associated protein 1 (UBAP-1); UBAP-1, also called nasopharyngeal carcinoma-associated gene 20 protein, is a ubiquitously expressed protein that may play an important role in the ubiquitin pathway and cell progression. It co-localizes with TDP-43 proteins in neuronal cytoplasmic inclusions and acts as a genetic risk factor for frontotemporal lobar degeneration (FTLD). Moreover, UBAP-1, together with VPS37A, forms an endosome-specific endosomal sorting complexes I required for transport (ESCRT-I) complex that displays a restricted cellular function, ubiquitin-dependent endosomal sorting and multivesicular body (MVB) biogenesis. UBAP-1 contains an N-terminal UBAP-1-MVB12-associated (UMA) domain, and two tandem ubiquitin-associated (UBA) domains that may be responsible for the binding of ubiquitin-conjugating enzymes. This model corresponds to UBA1 domain.


Pssm-ID: 270500  Cd Length: 43  Bit Score: 82.59  E-value: 7.60e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 387019555 386 LTSSEREYLEIVVGMGYSYEDVLKAMKRKGQSIDQILEYLVVR 428
Cdd:cd14315    1 LSPSERQCVETVVGMGYSYECVLKAMKKKGQNIEQILEYLFAH 43
UBA2_UBAP1_like cd14316
UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, ...
 459-494 4.08e-13

UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, also called nasopharyngeal carcinoma-associated gene 20 protein, is a ubiquitously expressed protein that may play an important role in the ubiquitin pathway and cell progression. It co-localizes with TDP-43 proteins in neuronal cytoplasmic inclusions and acts as a genetic risk factor for frontotemporal lobar degeneration (FTLD). Moreover, UBAP-1, together with VPS37A, forms an endosome-specific endosomal sorting complexes I required for transport (ESCRT-I) complex that displays a restricted cellular function, ubiquitin-dependent endosomal sorting and multivesicular body (MVB) biogenesis. UBAP-1 contains an N-terminal UBAP-1-MVB12-associated (UMA) domain, and two tandem ubiquitin-associated (UBA) domains that may be responsible for the binding of ubiquitin-conjugating enzymes. This model corresponds to UBA2 domain.


Pssm-ID: 270501  Cd Length: 37  Bit Score: 63.32  E-value: 4.08e-13
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 387019555 459 LQLMSKFQEMGFKLKDIKEALLLHNNDQDNALEDLM 494
Cdd:cd14316    2 LKLLNQLHELGFPEDKIKEALLKHNNDRDKALDELV 37
UBA pfam00627
UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes ...
 389-425 6.03e-03

UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes the previously defined UBA and TS-N domains. The UBA-domain (ubiquitin associated domain) is a novel sequence motif found in several proteins having connections to ubiquitin and the ubiquitination pathway. The structure of the UBA domain consists of a compact three helix bundle. This domain is found at the N terminus of EF-TS hence the name TS-N. The structure of EF-TS is known and this domain is implicated in its interaction with EF-TU. The domain has been found in non EF-TS proteins such as alpha-NAC and MJ0280.


Pssm-ID: 395502 [Multi-domain]  Cd Length: 37  Bit Score: 34.34  E-value: 6.03e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 387019555  389 SEREYLEIVVGMGYSYEDVLKAMKRKGQSIDQILEYL 425
Cdd:pfam00627   1 EDEEAIQRLVEMGFDREQVREALRATGNNVERAAEYL 37
 
Name Accession Description Interval E-value
UBA1_UBAP1 cd14315
UBA1 domain found in vertebrate ubiquitin-associated protein 1 (UBAP-1); UBAP-1, also called ...
 386-428 7.60e-20

UBA1 domain found in vertebrate ubiquitin-associated protein 1 (UBAP-1); UBAP-1, also called nasopharyngeal carcinoma-associated gene 20 protein, is a ubiquitously expressed protein that may play an important role in the ubiquitin pathway and cell progression. It co-localizes with TDP-43 proteins in neuronal cytoplasmic inclusions and acts as a genetic risk factor for frontotemporal lobar degeneration (FTLD). Moreover, UBAP-1, together with VPS37A, forms an endosome-specific endosomal sorting complexes I required for transport (ESCRT-I) complex that displays a restricted cellular function, ubiquitin-dependent endosomal sorting and multivesicular body (MVB) biogenesis. UBAP-1 contains an N-terminal UBAP-1-MVB12-associated (UMA) domain, and two tandem ubiquitin-associated (UBA) domains that may be responsible for the binding of ubiquitin-conjugating enzymes. This model corresponds to UBA1 domain.


Pssm-ID: 270500  Cd Length: 43  Bit Score: 82.59  E-value: 7.60e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 387019555 386 LTSSEREYLEIVVGMGYSYEDVLKAMKRKGQSIDQILEYLVVR 428
Cdd:cd14315    1 LSPSERQCVETVVGMGYSYECVLKAMKKKGQNIEQILEYLFAH 43
UBA2_UBAP1_like cd14316
UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, ...
 459-494 4.08e-13

UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins; UBAP-1, also called nasopharyngeal carcinoma-associated gene 20 protein, is a ubiquitously expressed protein that may play an important role in the ubiquitin pathway and cell progression. It co-localizes with TDP-43 proteins in neuronal cytoplasmic inclusions and acts as a genetic risk factor for frontotemporal lobar degeneration (FTLD). Moreover, UBAP-1, together with VPS37A, forms an endosome-specific endosomal sorting complexes I required for transport (ESCRT-I) complex that displays a restricted cellular function, ubiquitin-dependent endosomal sorting and multivesicular body (MVB) biogenesis. UBAP-1 contains an N-terminal UBAP-1-MVB12-associated (UMA) domain, and two tandem ubiquitin-associated (UBA) domains that may be responsible for the binding of ubiquitin-conjugating enzymes. This model corresponds to UBA2 domain.


Pssm-ID: 270501  Cd Length: 37  Bit Score: 63.32  E-value: 4.08e-13
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 387019555 459 LQLMSKFQEMGFKLKDIKEALLLHNNDQDNALEDLM 494
Cdd:cd14316    2 LKLLNQLHELGFPEDKIKEALLKHNNDRDKALDELV 37
UBA2_KPC2 cd14304
UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar ...
 460-494 2.91e-04

UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins; KPC2, also called ubiquitin-associated domain-containing protein 1 (UBAC1), or glialblastoma cell differentiation-related protein 1, is one of two subunits of Kip1 ubiquitination-promoting complex (KPC), a novel E3 ubiquitin-protein ligase that also contains KPC1 subunit and regulates the ubiquitin-dependent degradation of the cyclin-dependent kinase (CDK) inhibitor p27 at G1 phase. KPC2 contains a ubiquitin-like (UBL) domain and two ubiquitin-associated (UBA) domains. This model corresponds to the UBA2 domain.


Pssm-ID: 270489  Cd Length: 39  Bit Score: 38.39  E-value: 2.91e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 387019555 460 QLMSKFQEMGFKLKDIKEALLLHNNDQDNALEDLM 494
Cdd:cd14304    4 RAVQSLMEMGFEEEDVLEALRVTRNNQNAACEWLL 38
UBA cd14270
UBA domain found in proteins involved in ubiquitin-mediated proteolysis; The ...
 458-491 1.06e-03

UBA domain found in proteins involved in ubiquitin-mediated proteolysis; The ubiquitin-associated (UBA) domains are commonly occurring sequence motifs found in proteins involved in ubiquitin-mediated proteolysis. They contribute to ubiquitin (Ub) binding or ubiquitin-like (UbL) domain binding. However, some kinds of UBA domains can only the bind UbL domain, but not the Ub domain. UBA domains are normally comprised of compact three-helix bundles which contain a conserved GF/Y-loop. They can bind polyubiquitin with high affinity. They also bind monoubiquitin and other proteins. Most UBA domain-containing proteins have one UBA domain, but some harbor two or three UBA domains.


Pssm-ID: 270456 [Multi-domain]  Cd Length: 30  Bit Score: 36.56  E-value: 1.06e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 387019555 458 ILQLMskfqEMGFKLKDIKEALLLHNNDQDNALE 491
Cdd:cd14270    1 LAQLV----EMGFSREQARRALRATNGDVEAAVE 30
UBA pfam00627
UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes ...
 389-425 6.03e-03

UBA/TS-N domain; This small domain is composed of three alpha helices. This family includes the previously defined UBA and TS-N domains. The UBA-domain (ubiquitin associated domain) is a novel sequence motif found in several proteins having connections to ubiquitin and the ubiquitination pathway. The structure of the UBA domain consists of a compact three helix bundle. This domain is found at the N terminus of EF-TS hence the name TS-N. The structure of EF-TS is known and this domain is implicated in its interaction with EF-TU. The domain has been found in non EF-TS proteins such as alpha-NAC and MJ0280.


Pssm-ID: 395502 [Multi-domain]  Cd Length: 37  Bit Score: 34.34  E-value: 6.03e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 387019555  389 SEREYLEIVVGMGYSYEDVLKAMKRKGQSIDQILEYL 425
Cdd:pfam00627   1 EDEEAIQRLVEMGFDREQVREALRATGNNVERAAEYL 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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