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Conserved domains on  [gi|384942406|gb|AFI34808|]
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nucleolar protein 14 [Macaca mulatta]

Protein Classification

nucleolar 14 family protein( domain architecture ID 12050684)

nucleolar 14 family protein similar to human nucleolar protein 14 (NOP14) that is involved in nucleolar processing of pre-18S ribosomal RNA

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Nop14 pfam04147
Nop14-like family; Emg1 and Nop14 are novel proteins whose interaction is required for the ...
30-846 0e+00

Nop14-like family; Emg1 and Nop14 are novel proteins whose interaction is required for the maturation of the 18S rRNA and for 40S ribosome production.


:

Pssm-ID: 461196  Cd Length: 835  Bit Score: 894.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406   30 NPFEVKVNRQKFQILGRKTRHDVGLPGVSRARALRKRTQTLLKEYKERDKSNVFRDKRFGEYNSSMSPEEKMMKRFALEQ 109
Cdd:pfam04147   9 NPFEVKVNKPKFDVLGRKTKGDVGRPGVSRSAAEEKRKKTLLKEYQRRNKSGGFVDRRFGENDPTMSPEEKMLERFTRER 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  110 QRHHEKKSIYNLNEDEE--LTHYGQSLADIEKHNDIVDSDSDAEDRGALSAELT-AAHFGGGGGLlhkktqqEGEEQGKA 186
Cdd:pfam04147  89 QRKSKKKSMFNLEDDEEegLTHYGQSLSDIDDFDDDDDDDSEEEEDGQLDLKRVrRAHFGGGEDD-------EEEEPERK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  187 KSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKP------DAYDMMVREL 260
Cdd:pfam04147 162 KSKKEVMEEVIAKSKLHKYERQKAKEEDEELREELDKELKDLRSLLSGSKRPKPEQAKKPEEKPdrkkpdDDYDKLVREL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  261 GFEMKAQPSNRMKTEAELAKEEQERLKKLEAERLRRMLGK---DEDENVKKPKHISADDLNDGFVLDK--DDRRLLSYKD 335
Cdd:pfam04147 242 AFDKRAKPSDRTKTEEELAEEEKERLEKLEEERLRRMRGEedeEEEDGKKKKKHKSADDLDDDFVVDDddDDEEFGLGKG 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  336 GKM---------NVEEDGQEEQSKEASDPESNEEEGDSSGREDTEESDSPDGHSDLESNVESEEENEKPAKEqrqtPGRG 406
Cdd:pfam04147 322 IKErptatelgdEDEDDFIIDDDLVESESDLELDEEEEDEEEEDDEDEDEEEEEDDDDLSDLESEEDEEDDE----FEEE 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  407 PTSGKGRAGKAAGDELPYTFAAPESYEELRSLLLGRSMEEQLLVVERIQKCNHPSLAEGNKAKLEKLFGFLLEYVGDLAT 486
Cdd:pfam04147 398 KKKKKKKDEEGAKEELPYTFPCPESHEEFLELLEGHSPEDLPTVVQRIRALHHPSLAEGNKEKLQKFFGVLLQHILYLAS 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  487 -DDPPDLRVIDKLVVHLYNLCQMFPESASDAVKFVLRDAMHEMEemietKGRATLPGLDVLIYLQITRLLFPTSDFWHPV 565
Cdd:pfam04147 478 qPPPPEFKVLESLVRHLHSLAKMFPEEAAECFREKLREMYKNRP-----KGLSTWPSLGDLILLRLIGLLFPTSDFFHPV 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  566 VTPALVCLSQLLTKCPVLSLQDVVKGLFVCCLFLEYVALSQRFIPELINFLLGILYIATPNKASQgSTLVHPFRALGKHS 645
Cdd:pfam04147 553 VTPALLLMGEYLGQCPIRSLQDIASGLFLCTLALQYQSLSKRYVPEVINFLLNTLLLLAPSKPKK-VPGVFPFREVGKPS 631
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  646 ELLvvSDREDVATWQQSSLSLRWASGLRAPTST-EANHIRLSCLAVGLALLKRCVLMYGSLPSFHAITGPLRALLTDHLA 724
Cdd:pfam04147 632 KLL--KSIKESSTSEKTPRKLSLSDLLTESSSSsETDSLKLSLLSTTLSLLDAFADLYSGLPAFPEIFEPILRLLQHLLN 709
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  725 DCSHPQELQELCQSTLTEMESQKQLC----RPLTCEKSKPVPLKLFTPRLVKVLEFGRKQGSSKEEQERKRLIHKHKREF 800
Cdd:pfam04147 710 KKLLPKALQEKLESLLDKLERLLKFArlsrRPLELQKHKPLPIKTYIPKFEENYDPDKHYDPDRERAELAKLKAEHKRER 789
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....*.
gi 384942406  801 KGAVREIRKDNQFLARMQLSEIMERDAERKRKVKQLFNSLATQEGE 846
Cdd:pfam04147 790 KGAIRELRKDARFLAREKLKEKKEKDAEYEKKVKRIVAELQSEEGE 835
 
Name Accession Description Interval E-value
Nop14 pfam04147
Nop14-like family; Emg1 and Nop14 are novel proteins whose interaction is required for the ...
30-846 0e+00

Nop14-like family; Emg1 and Nop14 are novel proteins whose interaction is required for the maturation of the 18S rRNA and for 40S ribosome production.


Pssm-ID: 461196  Cd Length: 835  Bit Score: 894.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406   30 NPFEVKVNRQKFQILGRKTRHDVGLPGVSRARALRKRTQTLLKEYKERDKSNVFRDKRFGEYNSSMSPEEKMMKRFALEQ 109
Cdd:pfam04147   9 NPFEVKVNKPKFDVLGRKTKGDVGRPGVSRSAAEEKRKKTLLKEYQRRNKSGGFVDRRFGENDPTMSPEEKMLERFTRER 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  110 QRHHEKKSIYNLNEDEE--LTHYGQSLADIEKHNDIVDSDSDAEDRGALSAELT-AAHFGGGGGLlhkktqqEGEEQGKA 186
Cdd:pfam04147  89 QRKSKKKSMFNLEDDEEegLTHYGQSLSDIDDFDDDDDDDSEEEEDGQLDLKRVrRAHFGGGEDD-------EEEEPERK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  187 KSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKP------DAYDMMVREL 260
Cdd:pfam04147 162 KSKKEVMEEVIAKSKLHKYERQKAKEEDEELREELDKELKDLRSLLSGSKRPKPEQAKKPEEKPdrkkpdDDYDKLVREL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  261 GFEMKAQPSNRMKTEAELAKEEQERLKKLEAERLRRMLGK---DEDENVKKPKHISADDLNDGFVLDK--DDRRLLSYKD 335
Cdd:pfam04147 242 AFDKRAKPSDRTKTEEELAEEEKERLEKLEEERLRRMRGEedeEEEDGKKKKKHKSADDLDDDFVVDDddDDEEFGLGKG 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  336 GKM---------NVEEDGQEEQSKEASDPESNEEEGDSSGREDTEESDSPDGHSDLESNVESEEENEKPAKEqrqtPGRG 406
Cdd:pfam04147 322 IKErptatelgdEDEDDFIIDDDLVESESDLELDEEEEDEEEEDDEDEDEEEEEDDDDLSDLESEEDEEDDE----FEEE 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  407 PTSGKGRAGKAAGDELPYTFAAPESYEELRSLLLGRSMEEQLLVVERIQKCNHPSLAEGNKAKLEKLFGFLLEYVGDLAT 486
Cdd:pfam04147 398 KKKKKKKDEEGAKEELPYTFPCPESHEEFLELLEGHSPEDLPTVVQRIRALHHPSLAEGNKEKLQKFFGVLLQHILYLAS 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  487 -DDPPDLRVIDKLVVHLYNLCQMFPESASDAVKFVLRDAMHEMEemietKGRATLPGLDVLIYLQITRLLFPTSDFWHPV 565
Cdd:pfam04147 478 qPPPPEFKVLESLVRHLHSLAKMFPEEAAECFREKLREMYKNRP-----KGLSTWPSLGDLILLRLIGLLFPTSDFFHPV 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  566 VTPALVCLSQLLTKCPVLSLQDVVKGLFVCCLFLEYVALSQRFIPELINFLLGILYIATPNKASQgSTLVHPFRALGKHS 645
Cdd:pfam04147 553 VTPALLLMGEYLGQCPIRSLQDIASGLFLCTLALQYQSLSKRYVPEVINFLLNTLLLLAPSKPKK-VPGVFPFREVGKPS 631
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  646 ELLvvSDREDVATWQQSSLSLRWASGLRAPTST-EANHIRLSCLAVGLALLKRCVLMYGSLPSFHAITGPLRALLTDHLA 724
Cdd:pfam04147 632 KLL--KSIKESSTSEKTPRKLSLSDLLTESSSSsETDSLKLSLLSTTLSLLDAFADLYSGLPAFPEIFEPILRLLQHLLN 709
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  725 DCSHPQELQELCQSTLTEMESQKQLC----RPLTCEKSKPVPLKLFTPRLVKVLEFGRKQGSSKEEQERKRLIHKHKREF 800
Cdd:pfam04147 710 KKLLPKALQEKLESLLDKLERLLKFArlsrRPLELQKHKPLPIKTYIPKFEENYDPDKHYDPDRERAELAKLKAEHKRER 789
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....*.
gi 384942406  801 KGAVREIRKDNQFLARMQLSEIMERDAERKRKVKQLFNSLATQEGE 846
Cdd:pfam04147 790 KGAIRELRKDARFLAREKLKEKKEKDAEYEKKVKRIVAELQSEEGE 835
PTZ00121 PTZ00121
MAEBL; Provisional
61-370 2.56e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.21  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406   61 RALRKRTQTLLKEYKERDKSNVFR---DKRFGEYNSSMSPEEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYGQSLADI 137
Cdd:PTZ00121 1517 KAEEAKKADEAKKAEEAKKADEAKkaeEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEE 1596
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  138 EKHNDIVDSDSDAEDRGALSAELTAAHFGGGGGLLHKKTQQ----EGEEQGKAKSRKELIEELIAKSKQEKRERQAQRED 213
Cdd:PTZ00121 1597 VMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQlkkkEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKK 1676
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  214 ALELTEKLDQDWKEIQTLlshKTPKSENRDKKEKPKPDAYDmmVRELGFEMKAQPSNRMKTEaELAKEEQERLKKleAER 293
Cdd:PTZ00121 1677 AEEAKKAEEDEKKAAEAL---KKEAEEAKKAEELKKKEAEE--KKKAEELKKAEEENKIKAE-EAKKEAEEDKKK--AEE 1748
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 384942406  294 LRrmlgKDEDENvKKPKHISADDLNDGFVLDKDDRRLLsyKDGKMNVEEDGQEEQSKEASDPESNEEEGDSSGREDT 370
Cdd:PTZ00121 1749 AK----KDEEEK-KKIAHLKKEEEKKAEEIRKEKEAVI--EEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGN 1818
CDC37_N smart01071
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
202-321 1.88e-04

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 198139 [Multi-domain]  Cd Length: 154  Bit Score: 42.79  E-value: 1.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406   202 QEKRERQAQREDALELTEKLDQDWKEIQTLLSHKtpksenRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKE 281
Cdd:smart01071  39 QARVERMEEIKNLKYELIMNDHLNKRIDKLLKGL------REEELSPETPTYNEMLAELQDQLKKELEEANGDSEGLLEE 112
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 384942406   282 EQERLKKLEAErLRRMLGKDEDENVKKPKHISADDLNDGF 321
Cdd:smart01071 113 LKKHRDKLKKE-QKELRKKLDELEKEEKKKIWSVDTHTGF 151
 
Name Accession Description Interval E-value
Nop14 pfam04147
Nop14-like family; Emg1 and Nop14 are novel proteins whose interaction is required for the ...
30-846 0e+00

Nop14-like family; Emg1 and Nop14 are novel proteins whose interaction is required for the maturation of the 18S rRNA and for 40S ribosome production.


Pssm-ID: 461196  Cd Length: 835  Bit Score: 894.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406   30 NPFEVKVNRQKFQILGRKTRHDVGLPGVSRARALRKRTQTLLKEYKERDKSNVFRDKRFGEYNSSMSPEEKMMKRFALEQ 109
Cdd:pfam04147   9 NPFEVKVNKPKFDVLGRKTKGDVGRPGVSRSAAEEKRKKTLLKEYQRRNKSGGFVDRRFGENDPTMSPEEKMLERFTRER 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  110 QRHHEKKSIYNLNEDEE--LTHYGQSLADIEKHNDIVDSDSDAEDRGALSAELT-AAHFGGGGGLlhkktqqEGEEQGKA 186
Cdd:pfam04147  89 QRKSKKKSMFNLEDDEEegLTHYGQSLSDIDDFDDDDDDDSEEEEDGQLDLKRVrRAHFGGGEDD-------EEEEPERK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  187 KSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKP------DAYDMMVREL 260
Cdd:pfam04147 162 KSKKEVMEEVIAKSKLHKYERQKAKEEDEELREELDKELKDLRSLLSGSKRPKPEQAKKPEEKPdrkkpdDDYDKLVREL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  261 GFEMKAQPSNRMKTEAELAKEEQERLKKLEAERLRRMLGK---DEDENVKKPKHISADDLNDGFVLDK--DDRRLLSYKD 335
Cdd:pfam04147 242 AFDKRAKPSDRTKTEEELAEEEKERLEKLEEERLRRMRGEedeEEEDGKKKKKHKSADDLDDDFVVDDddDDEEFGLGKG 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  336 GKM---------NVEEDGQEEQSKEASDPESNEEEGDSSGREDTEESDSPDGHSDLESNVESEEENEKPAKEqrqtPGRG 406
Cdd:pfam04147 322 IKErptatelgdEDEDDFIIDDDLVESESDLELDEEEEDEEEEDDEDEDEEEEEDDDDLSDLESEEDEEDDE----FEEE 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  407 PTSGKGRAGKAAGDELPYTFAAPESYEELRSLLLGRSMEEQLLVVERIQKCNHPSLAEGNKAKLEKLFGFLLEYVGDLAT 486
Cdd:pfam04147 398 KKKKKKKDEEGAKEELPYTFPCPESHEEFLELLEGHSPEDLPTVVQRIRALHHPSLAEGNKEKLQKFFGVLLQHILYLAS 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  487 -DDPPDLRVIDKLVVHLYNLCQMFPESASDAVKFVLRDAMHEMEemietKGRATLPGLDVLIYLQITRLLFPTSDFWHPV 565
Cdd:pfam04147 478 qPPPPEFKVLESLVRHLHSLAKMFPEEAAECFREKLREMYKNRP-----KGLSTWPSLGDLILLRLIGLLFPTSDFFHPV 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  566 VTPALVCLSQLLTKCPVLSLQDVVKGLFVCCLFLEYVALSQRFIPELINFLLGILYIATPNKASQgSTLVHPFRALGKHS 645
Cdd:pfam04147 553 VTPALLLMGEYLGQCPIRSLQDIASGLFLCTLALQYQSLSKRYVPEVINFLLNTLLLLAPSKPKK-VPGVFPFREVGKPS 631
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  646 ELLvvSDREDVATWQQSSLSLRWASGLRAPTST-EANHIRLSCLAVGLALLKRCVLMYGSLPSFHAITGPLRALLTDHLA 724
Cdd:pfam04147 632 KLL--KSIKESSTSEKTPRKLSLSDLLTESSSSsETDSLKLSLLSTTLSLLDAFADLYSGLPAFPEIFEPILRLLQHLLN 709
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  725 DCSHPQELQELCQSTLTEMESQKQLC----RPLTCEKSKPVPLKLFTPRLVKVLEFGRKQGSSKEEQERKRLIHKHKREF 800
Cdd:pfam04147 710 KKLLPKALQEKLESLLDKLERLLKFArlsrRPLELQKHKPLPIKTYIPKFEENYDPDKHYDPDRERAELAKLKAEHKRER 789
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....*.
gi 384942406  801 KGAVREIRKDNQFLARMQLSEIMERDAERKRKVKQLFNSLATQEGE 846
Cdd:pfam04147 790 KGAIRELRKDARFLAREKLKEKKEKDAEYEKKVKRIVAELQSEEGE 835
PTZ00121 PTZ00121
MAEBL; Provisional
61-370 2.56e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.21  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406   61 RALRKRTQTLLKEYKERDKSNVFR---DKRFGEYNSSMSPEEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYGQSLADI 137
Cdd:PTZ00121 1517 KAEEAKKADEAKKAEEAKKADEAKkaeEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEE 1596
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  138 EKHNDIVDSDSDAEDRGALSAELTAAHFGGGGGLLHKKTQQ----EGEEQGKAKSRKELIEELIAKSKQEKRERQAQRED 213
Cdd:PTZ00121 1597 VMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQlkkkEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKK 1676
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  214 ALELTEKLDQDWKEIQTLlshKTPKSENRDKKEKPKPDAYDmmVRELGFEMKAQPSNRMKTEaELAKEEQERLKKleAER 293
Cdd:PTZ00121 1677 AEEAKKAEEDEKKAAEAL---KKEAEEAKKAEELKKKEAEE--KKKAEELKKAEEENKIKAE-EAKKEAEEDKKK--AEE 1748
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 384942406  294 LRrmlgKDEDENvKKPKHISADDLNDGFVLDKDDRRLLsyKDGKMNVEEDGQEEQSKEASDPESNEEEGDSSGREDT 370
Cdd:PTZ00121 1749 AK----KDEEEK-KKIAHLKKEEEKKAEEIRKEKEAVI--EEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGN 1818
CDC37_N smart01071
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
202-321 1.88e-04

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 198139 [Multi-domain]  Cd Length: 154  Bit Score: 42.79  E-value: 1.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406   202 QEKRERQAQREDALELTEKLDQDWKEIQTLLSHKtpksenRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEAELAKE 281
Cdd:smart01071  39 QARVERMEEIKNLKYELIMNDHLNKRIDKLLKGL------REEELSPETPTYNEMLAELQDQLKKELEEANGDSEGLLEE 112
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 384942406   282 EQERLKKLEAErLRRMLGKDEDENVKKPKHISADDLNDGF 321
Cdd:smart01071 113 LKKHRDKLKKE-QKELRKKLDELEKEEKKKIWSVDTHTGF 151
PRK05901 PRK05901
RNA polymerase sigma factor; Provisional
174-376 1.22e-03

RNA polymerase sigma factor; Provisional


Pssm-ID: 235640 [Multi-domain]  Cd Length: 509  Bit Score: 42.29  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406 174 KKTQQEGEE-QGKAKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIqtllshKTPKSENRDKKEKPKPDA 252
Cdd:PRK05901  14 EEAKKKLKKlAAKSKSKGFITKEEIKEALESKKKTPEQIDQVLIFLSGMVKDTDDA------TESDIPKKKTKTAAKAAA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406 253 ydmmvrelgfemKAQPSNRmKTEAELAKEEQERLKKLEAERLRRMLGKDEDENVKKPKHISADDLNDGFVLDKDDRRLLS 332
Cdd:PRK05901  88 ------------AKAPAKK-KLKDELDSSKKAEKKNALDKDDDLNYVKDIDVLNQADDDDDDDDDDDLDDDDIDDDDDDE 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 384942406 333 YKDGKMNVEEDGQEEQSK-EASDPESNEEEGDSSGREDTEESDSP 376
Cdd:PRK05901 155 DDDEDDDDDDVDDEDEEKkEAKELEKLSDDDDFVWDEDDSEALRQ 199
PTZ00121 PTZ00121
MAEBL; Provisional
59-372 1.34e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 1.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406   59 RARALRKRTQTLLKEYKERDKSNVFRDKRFGEYNSSMSPEEKmmKRFALEQQRHHEKKSIYNLNEDEELTHyGQSLADIE 138
Cdd:PTZ00121 1491 KAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEE--AKKADEAKKAEEKKKADELKKAEELKK-AEEKKKAE 1567
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  139 KHNDIVDSDSDAEDRGALSAELTAAHFGGGGGLLHKKTQQEGEEQGKAKSRKELIEELiAKSKQEKRERQAQREDALELT 218
Cdd:PTZ00121 1568 EAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEEL-KKAEEEKKKVEQLKKKEAEEK 1646
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  219 EKLDQDWKEIQtllSHKTPKSENRDKKEKPKPDAYdmmvrelgfEMKAQPSNRMKTEAELAKEEQERLKkleAERLRrml 298
Cdd:PTZ00121 1647 KKAEELKKAEE---ENKIKAAEEAKKAEEDKKKAE---------EAKKAEEDEKKAAEALKKEAEEAKK---AEELK--- 1708
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 384942406  299 gKDEDENVKKPKHISADDlndgfvldkddrrllsyKDGKMNVEE--DGQEEQSKEASDPESNEEEGDSSGREDTEE 372
Cdd:PTZ00121 1709 -KKEAEEKKKAEELKKAE-----------------EENKIKAEEakKEAEEDKKKAEEAKKDEEEKKKIAHLKKEE 1766
PTZ00121 PTZ00121
MAEBL; Provisional
178-371 1.81e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  178 QEGEEQGKA-KSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMM 256
Cdd:PTZ00121 1581 RKAEEAKKAeEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENK 1660
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  257 VRELGFEMKAQPSNRMKTEAELAKEEQER-----LKKLEAERLRRMLGKDEDENVKKPKHISADDLNDGFVLDKDDRRll 331
Cdd:PTZ00121 1661 IKAAEEAKKAEEDKKKAEEAKKAEEDEKKaaealKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKE-- 1738
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 384942406  332 SYKDGKMNVEEDGQEEQSKEASDPESNEEEGDSSGREDTE 371
Cdd:PTZ00121 1739 AEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKE 1778
DUF612 pfam04747
Protein of unknown function, DUF612; This family includes several uncharacterized proteins ...
174-312 3.47e-03

Protein of unknown function, DUF612; This family includes several uncharacterized proteins from Caenorhabditis elegans.


Pssm-ID: 282585 [Multi-domain]  Cd Length: 511  Bit Score: 40.82  E-value: 3.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  174 KKTQQEGEEQGKAKSRKELIEELIAKSKQEKRER-QAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDA 252
Cdd:pfam04747  95 KKAAEKEARRAEAEAKKRAAQEEEHKQWKAEQERiQKEQEKKEADLKKLQAEKKKEKAVKAEKAEKAEKTKKASTPAPVE 174
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  253 YDMMVRELGFEMKAQPSNRMKTEAELAKEEQERLKKLEAERLRRMLGKDEDENVKKPKHI 312
Cdd:pfam04747 175 EEIVVKKVANDRSAAPAPEPKTPTNTPAEPAEQVQEITGKKNKKNKKKSESEATAAPASV 234
PTZ00121 PTZ00121
MAEBL; Provisional
64-361 6.99e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 6.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406   64 RKRTQTLLKEYKERDKSNVFRDKRFGEYNSSMSPEEKMMKRFALEQQRHHEKKSIYNLNEDEELTHYGQSLADIEKHNDI 143
Cdd:PTZ00121 1314 AKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKA 1393
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  144 VDSDSDAEDRGALSAELTAAHFGGGGGLLHKKTQQE----------GEEQGKAKSRKELIEEliAKSKQEKRERQAQRED 213
Cdd:PTZ00121 1394 DEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEkkkadeakkkAEEAKKADEAKKKAEE--AKKAEEAKKKAEEAKK 1471
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  214 ALELTEKLDQDWK--EIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRE---LGFEMKAQPSNRMKTEAELAKEEQ--ERL 286
Cdd:PTZ00121 1472 ADEAKKKAEEAKKadEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEeakKADEAKKAEEAKKADEAKKAEEKKkaDEL 1551
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 384942406  287 KKLE----AERLRRMLGKDEDENVKKPKHISADDLNDGFVLDKDDRRLLSYKDGKMNVEEDGQEEQSKEASDPESNEEE 361
Cdd:PTZ00121 1552 KKAEelkkAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEE 1630
PTZ00121 PTZ00121
MAEBL; Provisional
104-446 7.35e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 7.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  104 RFALEQQRHHEKKSIYNLNEDEELTHYGQSLADIEKHNDIVDSDSDAEDRGALSAELTAAhfGGGGGLLHKKTQQEGEEQ 183
Cdd:PTZ00121 1212 RKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAA--IKAEEARKADELKKAEEK 1289
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  184 GKAKSRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDaydmmvrELGFE 263
Cdd:PTZ00121 1290 KKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAAD-------EAEAA 1362
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  264 MKAQPSNRMKTEAELAKEEQERlKKLEAERLRRMLGKDEDENVKKpkhisADDLNDGFVLDKDDRRLlsykdgKMNVEED 343
Cdd:PTZ00121 1363 EEKAEAAEKKKEEAKKKADAAK-KKAEEKKKADEAKKKAEEDKKK-----ADELKKAAAAKKKADEA------KKKAEEK 1430
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  344 GQEEQSKEASDPESNEEEgdssGREDTEESDSPDGHSDLESNVESEEENEKPAKEQRQTPgrgPTSGKGRAGKAAGDELP 423
Cdd:PTZ00121 1431 KKADEAKKKAEEAKKADE----AKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKAD---EAKKKAEEAKKKADEAK 1503
                         330       340
                  ....*....|....*....|...
gi 384942406  424 YTFAAPESYEELRSLLLGRSMEE 446
Cdd:PTZ00121 1504 KAAEAKKKADEAKKAEEAKKADE 1526
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
174-372 9.37e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 39.72  E-value: 9.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  174 KKTQQEGEEQGKAKSRKELIEELIAKSKQEKR---ERQAQRE---DALELTEKLDQDWKEIQTLLSHKTPKSEnrdKKEK 247
Cdd:pfam17380 351 ERIRQEERKRELERIRQEEIAMEISRMRELERlqmERQQKNErvrQELEAARKVKILEEERQRKIQQQKVEME---QIRA 427
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384942406  248 PKPDAYDMMVRELGfEMKAQPSNRMKTEAELAKEEQERLKKLEAERLRRMLGKDEDENVKKpkhiSADDLNDGFV---LD 324
Cdd:pfam17380 428 EQEEARQREVRRLE-EERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRK----RAEEQRRKILekeLE 502
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 384942406  325 KDDRRLLSYKDGKMNVEEDGQEEQSKEASDPESNEEEGDSSGREDTEE 372
Cdd:pfam17380 503 ERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEE 550
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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