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Conserved domains on  [gi|380797743|gb|AFE70747|]
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protein spinster homolog 2, partial [Macaca mulatta]

Protein Classification

spinster family MFS transporter( domain architecture ID 13023647)

spinster family major facilitator superfamily (MFS) transporter may function as a sphingolipid transporter that plays a central role in endosome and/or lysosome storage

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0006869
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1.49

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 67-481 0e+00

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 528.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  67 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 146
Cdd:cd17328    2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 147 SFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRV 226
Cdd:cd17328   82 SFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 227 SPVLGMITGTLILILVPATKRGHADQLGDQLKTRTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQV 306
Cdd:cd17328  160 TGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 307 VqktaetcnSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLKTQRADPLVCAVGMLGSAIFICLIFVAAKSSIVGA 386
Cdd:cd17328  240 V--------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLA 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 387 YICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQStKDSPLWEFLSLGYAL 466
Cdd:cd17328  312 WVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN-KDSPLAEAASLQYAL 390

                        410
                 ....*....|....*
gi 380797743 467 MLCPFVVVLGGMFFL 481
Cdd:cd17328  391 LLCSFVLVLGGFFFL 405
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 67-481 0e+00

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 528.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  67 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 146
Cdd:cd17328    2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 147 SFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRV 226
Cdd:cd17328   82 SFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 227 SPVLGMITGTLILILVPATKRGHADQLGDQLKTRTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQV 306
Cdd:cd17328  160 TGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 307 VqktaetcnSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLKTQRADPLVCAVGMLGSAIFICLIFVAAKSSIVGA 386
Cdd:cd17328  240 V--------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLA 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 387 YICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQStKDSPLWEFLSLGYAL 466
Cdd:cd17328  312 WVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN-KDSPLAEAASLQYAL 390

                        410
                 ....*....|....*
gi 380797743 467 MLCPFVVVLGGMFFL 481
Cdd:cd17328  391 LLCSFVLVLGGFFFL 405
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
56-481 2.09e-31

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 124.60  E-value: 2.09e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  56 ASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCG 135
Cdd:COG2271    2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 136 IFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ 215
Cdd:COG2271   82 LLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 216 AAGdWHWALRVSPVLGMITGTLILILVpatkrghadqlgdqlktrtswlrdmkalirnrsyvfsSLATSAVSFATGALGM 295
Cdd:COG2271  160 AFG-WRAAFLILGLPGLLLALLRFWLL-------------------------------------ALAYFLVYFALYGFLT 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 296 WIPLYLHRAQVVqktaetcnsppcGAKDSLIFGAITCFTGFLGVVTGAgatrWCRLKTQRADPLVCAVGMLGSAIFICLI 375
Cdd:COG2271  202 WLPTYLVEVRGL------------SLAQAGLLLSLPFLAGIVGSLLGG----WLSDRLGRRRKLVLAIGLLLAALALLLL 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 376 FVAakSSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSfTSHLLGDAGSPYLIGFISDLirqstkdsp 455
Cdd:COG2271  266 ALL--PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVN-TFGFLGGALGPLLVGYLLDA--------- 333

                        410       420
                 ....*....|....*....|....*.
gi 380797743 456 lwefLSLGYALMLCPFVVVLGGMFFL 481
Cdd:COG2271  334 ----TGYQAAFLLLAALALLAALLAL 355
MFS_1 pfam07690
Major Facilitator Superfamily;
69-430 5.57e-23

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 99.80  E-value: 5.57e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743   69 LSLGNVLNYLDRYTVAGVL-LDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSS 147
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  148 FIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVS 227
Cdd:pfam07690  81 FASS--LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  228 PVLGMITGTLILILVPATKRGHADQLGDQLKTRTSWLRDmkalIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVV 307
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA----LLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  308 QKTAetcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLKTQRadpLVCAVGMLGSAIFICLIFVAAKSSIVGAY 387
Cdd:pfam07690 234 ALLA------------GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL---LALLLLILAALGLLLLSLTLSSLWLLLAL 298

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 380797743  388 ICIFVGETLLFSNWAItadILMYVVIPTRRATAVALQSFTSHL 430
Cdd:pfam07690 299 LLLGFGFGLVFPALNA---LVSDLAPKEERGTASGLYNTAGSL 338
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 71-475 1.43e-16

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 81.61  E-value: 1.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743   71 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIp 150
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  151 qQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGY-ITGSSVkqAAGDWHWALRVSPV 229
Cdd:TIGR00893  80 -GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGpLVGWIL--IHFSWQWAFIIEGV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  230 LGMITGTLILILVP----------------ATKRGHADQLGDQlKTRTSWLRDMKALiRNRSYVFSSLATSAVSFATGAL 293
Cdd:TIGR00893 157 LGIIWGVLWLKFIPdppqkakwlteeekyiVVGGLLAEQQGKG-PSTPKKYQIKELL-KDRRVWGLALGQFLVNIGLGFF 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  294 GMWIPLYLHRAQVVQktaetcnsppcgAKDSLIFGAITCFTGFLGVVTGAGATRWCRLKTQR---ADPLVCAVGMLGS-A 369
Cdd:TIGR00893 235 LTWFPTYLVQERGLS------------ILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSlvfARKTAIIAGLVLSlL 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  370 IFICLIFVAAKSSIVGAYICIFvGETLLFSNWAITADILmyvvipTRRATAVALQSFtsHLLGDAGS---PYLIGFIsdl 446
Cdd:TIGR00893 303 MFATNYVNIPYAALALVALGFF-GLGAGAIGWALISDNA------PGNIAGLTGGLI--NSLGNLGGivgPIVIGAI--- 370

                         410       420
                  ....*....|....*....|....*....
gi 380797743  447 irQSTKDSPLWEFLSLGYALMLCPFVVVL 475
Cdd:TIGR00893 371 --AATTGSFAGALMVVAALALIGALSYLL 397
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
87-289 4.54e-04

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 42.59  E-value: 4.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  87 LLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIpqQYFWLLVLSRGLVGI 166
Cdd:PRK11102  14 LPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALA--QTIDQLIYMRFLHGL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 167 GEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVPATk 246
Cdd:PRK11102  92 AAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFS-WHAIFWVLALAAILAAALVFFFIPET- 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 380797743 247 rgHADQLGDQLKTRTSwLRDMKALIRNRSyVFSSLATSAVSFA 289
Cdd:PRK11102 170 --LPKERRQPFHLRTT-IRNFASLFRHKR-VLGYMLASGFSFA 208
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 67-481 0e+00

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 528.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  67 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 146
Cdd:cd17328    2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 147 SFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRV 226
Cdd:cd17328   82 SFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 227 SPVLGMITGTLILILVPATKRGHADQLGDQLKTRTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQV 306
Cdd:cd17328  160 TGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 307 VqktaetcnSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLKTQRADPLVCAVGMLGSAIFICLIFVAAKSSIVGA 386
Cdd:cd17328  240 V--------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLA 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 387 YICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQStKDSPLWEFLSLGYAL 466
Cdd:cd17328  312 WVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN-KDSPLAEAASLQYAL 390

                        410
                 ....*....|....*
gi 380797743 467 MLCPFVVVLGGMFFL 481
Cdd:cd17328  391 LLCSFVLVLGGFFFL 405
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
56-481 2.09e-31

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 124.60  E-value: 2.09e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  56 ASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCG 135
Cdd:COG2271    2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 136 IFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ 215
Cdd:COG2271   82 LLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 216 AAGdWHWALRVSPVLGMITGTLILILVpatkrghadqlgdqlktrtswlrdmkalirnrsyvfsSLATSAVSFATGALGM 295
Cdd:COG2271  160 AFG-WRAAFLILGLPGLLLALLRFWLL-------------------------------------ALAYFLVYFALYGFLT 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 296 WIPLYLHRAQVVqktaetcnsppcGAKDSLIFGAITCFTGFLGVVTGAgatrWCRLKTQRADPLVCAVGMLGSAIFICLI 375
Cdd:COG2271  202 WLPTYLVEVRGL------------SLAQAGLLLSLPFLAGIVGSLLGG----WLSDRLGRRRKLVLAIGLLLAALALLLL 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 376 FVAakSSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSfTSHLLGDAGSPYLIGFISDLirqstkdsp 455
Cdd:COG2271  266 ALL--PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVN-TFGFLGGALGPLLVGYLLDA--------- 333

                        410       420
                 ....*....|....*....|....*.
gi 380797743 456 lwefLSLGYALMLCPFVVVLGGMFFL 481
Cdd:COG2271  334 ----TGYQAAFLLLAALALLAALLAL 355
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 69-481 1.28e-26

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 110.98  E-value: 1.28e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  69 LSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSF 148
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 149 IPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAG-DWHWALRVS 227
Cdd:cd06174   81 APS--FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGfGWRAVFLIA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 228 PVLGMITGTLILILVPATKrgHADQLGDQLKTRTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRaqvv 307
Cdd:cd06174  159 AALALLAAILLLLVVPDPP--ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD---- 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 308 qktaetcnsppCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLKTQRADPLVCAVGMLGSAIFICLIFVAAKSSIVGAY 387
Cdd:cd06174  233 -----------LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLL 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 388 ICIFVGETLLFSNWAITADIlmyvVIPTRRATAVALQSFTSHlLGDAGSPYLIGFISDlirqstkdsplwEFLSLGYALM 467
Cdd:cd06174  302 LLGFGLGGLLPLSFALIAEL----FPPEIRGTAFGLLNTFGF-LGGAIGPLLAGFLLA------------ATFGLTGAFL 364

                        410
                 ....*....|....
gi 380797743 468 LCPFVVVLGGMFFL 481
Cdd:cd06174  365 VLAVLLLLAAILLL 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
56-434 2.12e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 110.06  E-value: 2.12e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  56 ASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCG 135
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 136 IFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ 215
Cdd:COG2814   82 LLLFALGSLLCALAPS--LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 216 AAGdWHWALRVSPVLGMITGTLILILVPATKRghadqlgdqlKTRTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGM 295
Cdd:COG2814  160 LFG-WRWVFLVNAVLALLALLLLLRLLPESRP----------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFT 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 296 WIPLYLHRAqvvqktaetcnsppCGAKDSLIFGAITCFtgflGVVTGAGATRWCRLKTQRADPLVCAVGMLGSAIFICLI 375
Cdd:COG2814  229 YLPLYLQEV--------------LGLSASAAGLLLALF----GLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLL 290

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 380797743 376 FVAakSSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDA 434
Cdd:COG2814  291 ALA--GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 92-476 1.05e-23

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 102.65  E-value: 1.05e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  92 QHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASY 171
Cdd:cd17325   24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS--YWQLLLARFLQGLASAAV 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 172 STIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVPATKRGHAD 251
Cdd:cd17325  102 WPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCAALALLALVLALLLLPEPRPPPNK 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 252 QLGDQLKTRTSwlrdMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLhrAQVVQKTAETCnsppcgakdSLIFGAIT 331
Cdd:cd17325  181 RAVSAARLRSG----LRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYA--AELGGLSPAQI---------GLLFGAQG 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 332 CFTGFLGVVTGAGATRWCRLKtqradplVCAVGMLGSAI-FICLIFVAAKSSIVGAYICIFVGETLLFSnwAITAdILMY 410
Cdd:cd17325  246 LASALSQPPAGKLSDRIGRKP-------LILIGLLLSAVaLLLLPLATSFWLLLLLLALLGLGLGLVFP--ATLA-LLAD 315

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 380797743 411 VVIPTRRATAVAL-QSFTShlLGDAGSPYLIGFISDLIrqstkdSPLWEFLSLGYALMLCPFVVVLG 476
Cdd:cd17325  316 IVPPEGRGTAMGLfNTAFS--LGMVLGPLLGGFLYDAF------GFATPFLAAAALLLLAAVLFLLL 374
MFS_1 pfam07690
Major Facilitator Superfamily;
69-430 5.57e-23

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 99.80  E-value: 5.57e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743   69 LSLGNVLNYLDRYTVAGVL-LDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSS 147
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  148 FIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVS 227
Cdd:pfam07690  81 FASS--LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  228 PVLGMITGTLILILVPATKRGHADQLGDQLKTRTSWLRDmkalIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVV 307
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA----LLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  308 QKTAetcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLKTQRadpLVCAVGMLGSAIFICLIFVAAKSSIVGAY 387
Cdd:pfam07690 234 ALLA------------GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL---LALLLLILAALGLLLLSLTLSSLWLLLAL 298

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 380797743  388 ICIFVGETLLFSNWAItadILMYVVIPTRRATAVALQSFTSHL 430
Cdd:pfam07690 299 LLLGFGFGLVFPALNA---LVSDLAPKEERGTASGLYNTAGSL 338
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 67-475 1.60e-20

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 93.02  E-value: 1.60e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  67 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 146
Cdd:cd17319    6 PLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 147 SFIpqQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVkQAAGDWHWALRV 226
Cdd:cd17319   86 GFA--TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL-LLLFGWRWAFII 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 227 SPVLGMITGTLILILVpatkrghadqlgdqlktrtswlrdmkalirnRSYVFSSLATSAVSFATGALGMWIPLYLHRAqv 306
Cdd:cd17319  163 EGLLGLLLAVLWWFYL-------------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQA-- 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 307 vqktaetcnsppcGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLKTQRADPLVCAVGMLGSAIFICLIFVAakSSIVGA 386
Cdd:cd17319  210 -------------RGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLT--TSPVVA 274

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 387 YICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGdAGSPYLIGFISDlirqsTKDSPLWEFLSLGyAL 466
Cdd:cd17319  275 VILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGG-FVAPLLIGYLVD-----ATGSYTAAFLFLA-AV 347


                 ....*....
gi 380797743 467 MLCPFVVVL 475
Cdd:cd17319  348 ALLAALLVL 356
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 68-303 1.96e-17

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 83.75  E-value: 1.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  68 ILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSS 147
Cdd:cd17324    3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 148 FIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVS 227
Cdd:cd17324   83 LAPS--FALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFLAI 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 380797743 228 PVLGMITGTLILILVPATKRGHAdqlgdqlkTRTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHR 303
Cdd:cd17324  160 AVLALLAALLLWRLLPSLPPKKP--------GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTD 227
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 55-345 2.83e-17

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 82.17  E-value: 2.83e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  55 PASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSC 134
Cdd:COG0477    5 DAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 135 GIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVK 214
Cdd:COG0477   85 GLLLFGLASLLCGLAPS--PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 215 QAAGdWHWALRVSPVLGMItGTLILILVPATKRGHADQLGDQLKTRTSWLRDMKALIRNRSYVFSSLATSAVSFATGALG 294
Cdd:COG0477  163 AALG-WRWIFLINAPLGLL-ALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALL 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 380797743 295 MWIPLYLHRAQVVQKTAETCNSPPCGAKDSLIFGAITCFTGFLGVVTGAGA 345
Cdd:COG0477  241 LLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLL 291
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 71-475 1.43e-16

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 81.61  E-value: 1.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743   71 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIp 150
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  151 qQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGY-ITGSSVkqAAGDWHWALRVSPV 229
Cdd:TIGR00893  80 -GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGpLVGWIL--IHFSWQWAFIIEGV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  230 LGMITGTLILILVP----------------ATKRGHADQLGDQlKTRTSWLRDMKALiRNRSYVFSSLATSAVSFATGAL 293
Cdd:TIGR00893 157 LGIIWGVLWLKFIPdppqkakwlteeekyiVVGGLLAEQQGKG-PSTPKKYQIKELL-KDRRVWGLALGQFLVNIGLGFF 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  294 GMWIPLYLHRAQVVQktaetcnsppcgAKDSLIFGAITCFTGFLGVVTGAGATRWCRLKTQR---ADPLVCAVGMLGS-A 369
Cdd:TIGR00893 235 LTWFPTYLVQERGLS------------ILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSlvfARKTAIIAGLVLSlL 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  370 IFICLIFVAAKSSIVGAYICIFvGETLLFSNWAITADILmyvvipTRRATAVALQSFtsHLLGDAGS---PYLIGFIsdl 446
Cdd:TIGR00893 303 MFATNYVNIPYAALALVALGFF-GLGAGAIGWALISDNA------PGNIAGLTGGLI--NSLGNLGGivgPIVIGAI--- 370

                         410       420
                  ....*....|....*....|....*....
gi 380797743  447 irQSTKDSPLWEFLSLGYALMLCPFVVVL 475
Cdd:TIGR00893 371 --AATTGSFAGALMVVAALALIGALSYLL 397
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
60-446 9.81e-15

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 75.69  E-value: 9.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  60 RGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFW 139
Cdd:COG2223    1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 140 SAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGd 219
Cdd:COG2223   81 GIGLLLLALAVS--YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 220 WHWALRVSPVLGMITGTLILILVPATKRGHAdqlgdqlKTRTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPL 299
Cdd:COG2223  158 WRNAFLILGILLLVVAVLAWLFLRDPPAGAA-------AAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPP 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 300 YLH-RAQVVQKTAetcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLKTqradplvcAVGMLGSAIFICLIFVA 378
Cdd:COG2223  231 YLVdQFGLSAATA------------GLLAALFALLGALGRPLGGWLSDRIGGRRV--------LLIVFALMALGLLLLAL 290

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 380797743 379 AKSSIVGAYICIFVgetlLFSNWAITADILMYVV---IPTRRATAVALQSFTSHLLGDAGSPYLIGFISDL 446
Cdd:COG2223  291 ALGSLWLFLVLFLL----LGLALGGGNGAVFALVpdiFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA 357
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 67-393 1.14e-14

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 75.28  E-value: 1.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  67 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 146
Cdd:cd17380    2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 147 SFIPQQYFWLLVLSRGLVGIGEA-SYSTIApTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALR 225
Cdd:cd17380   82 PLLAYSSLPLLILSRILLGLGEGvHFPSMT-SLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYG-WPSVFY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 226 VSPVLGMITGTLILILVPATkrghadqlgdqlktrtsWlrdmkALIrnrsyvfssLATSAVSFATGALGMWIPLYLHRAQ 305
Cdd:cd17380  160 FFGLLGLLWALVWLIYLPPV-----------------W-----AII---------VAHFCMNWGFYILLSWLPTYFHEVL 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 306 VVQktaetcnsppcgaKDSLIFGAITCFTGFL-GVVTGAGATRWC--RLKTQRADPLVCAVGMLGSAifICLIFVAAKSS 382
Cdd:cd17380  209 VPL-------------AKGWVFNVVPWLVMFPsSNVAGWLADHLIsrGWTVTSVRKLMQSIGFLGPA--LFLLLLSHTDS 273

                        330
                 ....*....|.
gi 380797743 383 IVGAYICIFVG 393
Cdd:cd17380  274 FSLALLCMSVA 284
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
82-481 3.36e-14

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 74.12  E-value: 3.36e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  82 TVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSR 161
Cdd:COG0738   26 LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS--YPLLLLAL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 162 GLVGIGEASYSTIAPTIIGDLFTKNTRTLMlSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVspvlgMITGTLILIL 241
Cdd:COG0738  104 FLLGLGLGLLDVAANPYVAALGPETAASRL-NLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPY-----LILAVLLLLL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 242 VPATKRGHADQLGDQLKTRTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQvvqktaetcnsppcGA 321
Cdd:COG0738  178 ALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL--------------GL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 322 KDSLIFGAITCFTG--FLGVVTGAGATRWCRLKTqradplVCAVGMLGSAIFIcLIFVAAKSSIVGAYICIFVGetLLFS 399
Cdd:COG0738  244 SEATAALGLSLFWGgmTIGRFLGGFLLKRFGPVR------LLRLSALLAAVGL-LLALLAPGPWLALIGLALVG--LGLS 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 400 NWAITADILMYVVIPTRRATAVALQSFTShLLGDAGSPYLIGFISDLIRqstkdsplwefLSLGYALMLCPFVVVLGGMF 479
Cdd:COG0738  315 LMFPTIFSLALDGLGKRTAAAVSAVLIMG-IVGGAIGPPLIGFLADAFG-----------LRAAFLVPLVCYLLILLLAL 382


                 ..
gi 380797743 480 FL 481
Cdd:COG0738  383 AL 384
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 68-444 1.18e-13

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 72.25  E-value: 1.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  68 ILSLGNVLNYLDRYTVAGVLLDIQQHF--GVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFS 145
Cdd:cd17316    3 LAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 146 SSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWhWALR 225
Cdd:cd17316   83 IGLLPT--PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGD-WGWR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 226 VSPVLGMITGTLILILVPATkrghadqlgdqlktrtswlrdmkalirnrsyVFSSLATSAVSFATGALGMWIPLYLhraq 305
Cdd:cd17316  160 ILFLIGALPALLALLLRRRT-------------------------------LLLILLWFFISFGYYGLTTFLPTYL---- 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 306 vvqktAETCNSPPcgAKDSLIFGAITCFTGFLGVVTGAGATRWCRLKTQradplvcAVGMLGSAIFICLIFVAAKSSIVG 385
Cdd:cd17316  205 -----QTVLGLSP--ATSSLYLLLISLGALVGALIAGLLSDRIGRKKTL-------VIGLILSGILALPLFYLLSGSPTL 270

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 386 AYICIFVGETLLFSNWAItADILMYVVIPTR-RATAVALQSFTSHLLGdAGSPYLIGFIS 444
Cdd:cd17316  271 LLLLLFILSFFVGGVWGA-LYAYLAELFPTEvRATGVGLSYNLGRLGG-GGAPPLIALLL 328
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 63-475 1.41e-13

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 72.22  E-value: 1.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  63 GAAAAILSLGNVLnyldrytVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAV 142
Cdd:cd17474    5 FFATLLAVLGVSI-------VDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 143 TFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVkqAAGDWHW 222
Cdd:cd17474   78 GLLCGLSDS--FALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL--AAISWRY 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 223 ALRVSPVLGMITGTLILILVPATKRghadqlgDQLKTRTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLH 302
Cdd:cd17474  154 PFFLLAALIPVAFLAILFLLPEPKE-------KAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLE 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 303 RAQVVqktaetcnsppcgakDSLIFGAITCFTGFLGVVTGAGATRWCRLKTQRADPLVcaVGMLGSAIFICLIFVAakSS 382
Cdd:cd17474  227 LLYGI---------------SPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILV--IGLLLYALSLLLLGFV--PS 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 383 IVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTsHLLGDAGSPYLIGFISDLIrqstkdSPLWEFLSL 462
Cdd:cd17474  288 LALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFV-RFLGQAVGPLLFGLLLEIF------GLSAPFLVG 360

                        410
                 ....*....|...
gi 380797743 463 GyALMLCPFVVVL 475
Cdd:cd17474  361 A-AIALAAAVLLA 372
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 82-265 9.83e-12

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 66.44  E-value: 9.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  82 TVAGVLLDIQQHF-GVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLS 160
Cdd:cd17473   17 AIAPALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDS--LYALLAS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 161 RGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVkqAAGDWHWalrvsPVLGMITGTLILI 240
Cdd:cd17473   95 RALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL--AEIGWRA-----PFLVYLLALPVLI 167

                        170       180       190
                 ....*....|....*....|....*....|.
gi 380797743 241 LV------PATKRGHADQLGDQLKTRTSWLR 265
Cdd:cd17473  168 LVllflpePARKSKSAASPGAATAAALPWKR 198
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
82-446 6.50e-11

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 64.12  E-value: 6.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  82 TVAGVLLD-IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLS 160
Cdd:COG2807   35 TSVGPLLPeIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPS--VALLLAG 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 161 RGLVGIGEASYSTIAPTIIGDLFTKNtRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITgtlILI 240
Cdd:COG2807  113 TALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALG-WRGALAVWALLALLA---LLL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 241 LVPATKRGHADQlgdqlkTRTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQKTAetcnsppcg 320
Cdd:COG2807  188 WLPLLRRRPAAA------AAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATA--------- 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 321 akdslifGAITCFTGFLGVVTGAGATRWC-RLKTQRadPLVCAVGMLGSAIFICLIFVAAKSSIVGAyICIFVGETLLFS 399
Cdd:COG2807  253 -------GLLLSLFQLAGIPGSLLVPLLAdRLGDRR--PLLLLLGLLGLAGLLGLLLAPGSLPWLWA-VLLGLGQGGLFP 322

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 380797743 400 nwAITADILMYVVIPTRRATAVAL-QSFTShlLGDAGSPYLIGFISDL 446
Cdd:COG2807  323 --LALTLIGLRARTPAEAAALSGMaQSVGY--LLAALGPLLVGALHDA 366
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 84-243 1.21e-10

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 62.98  E-value: 1.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  84 AGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGL 163
Cdd:cd17323   19 SPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPN--IAMLIILRFL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 164 VGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVP 243
Cdd:cd17323   97 QGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLG-WRWIFWFLAIISGFCLILIFLFLP 175
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 71-446 2.06e-10

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 62.39  E-value: 2.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743   71 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP 150
Cdd:TIGR00881   2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  151 QqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVL 230
Cdd:TIGR00881  82 S--LWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGII 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  231 GMITGTLILILV---PATK----------RGHADQLGDQLKTRTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWI 297
Cdd:TIGR00881 160 AIIVSLICFLLLrdsPQSCglppaeempnEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  298 PLYLhrAQVVQKTAETCNSppcgakdslifgAITCFtgFLGVVTGAGATRWCrlktqrADPLVCAVGMLGSAIFICLIFV 377
Cdd:TIGR00881 240 PLYL--TQEKGFSKEKASW------------AFTLY--ELGGLVGTLLAGWL------SDKLFNGRRGPLAVFFMALIIV 297

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 380797743  378 A-------AKSSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAgSPYLIGFISDL 446
Cdd:TIGR00881 298 SllvywlnPAANPLMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGIL-AGLPLGYLADG 372
Sugar_tr pfam00083
Sugar (and other) transporter;
65-243 2.20e-10

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 62.67  E-value: 2.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743   65 AAAILSLGNVLNYLDRYTVAGV--LLDIQQHFGVKDR-----GAGLLQSVFICSFMVAAPI----FGYLGDRFNRKVILS 133
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFltLIDFFKNFGLSKSvsslaALSVLSGLIVSIFSVGCFIgslfAGKLGDRFGRKKSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  134 CGIFFWSAVTFSSSFIPQQY-FWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSS 212
Cdd:pfam00083  81 IANVLFVIGAVLQGAAKGKWsVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160

                         170       180       190
                  ....*....|....*....|....*....|.
gi 380797743  213 VKQAAGDWHWalRVSPVLGMITGTLILILVP 243
Cdd:pfam00083 161 LNKTSNSDGW--RIPLGLQLVPALLLIIGLL 189
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 90-377 6.79e-10

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 61.45  E-value: 6.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743   90 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAvtfsSSFI---PqqYFWLLVLSRGLVGI 166
Cdd:pfam03137  27 IEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGL----GSLLfalP--HFLSFFLGQLLLGI 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  167 GEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWH-WALRVSPV---------LGMITGT 236
Cdd:pfam03137 101 GGTPIYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGkVSITLTPKdprwvgawwLGFLIAG 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  237 LILILV------------------------PATKRGHADQLGDQLKTRTSWLRD----MKALIRNRSYVFSSLATsaVSF 288
Cdd:pfam03137 181 LLLLLTaipffffpkslpgaakrrakkkkePHSQDIADLKKTKSLKKLGPSLKDfpkaLKRLLKNPVYMLLTLAS--VFE 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  289 ATGALGMWI--PLYLhrAQVVQKTAetcnsppcgAKDSLIFGAITCFTGFLGVVTGAGATRWCRLKTQRADPLVCAVGML 366
Cdd:pfam03137 259 FLLIAGYATflPKYI--ETQFGLSA---------STANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLV 327

                         330
                  ....*....|.
gi 380797743  367 GSAIFICLIFV 377
Cdd:pfam03137 328 SLLLSLLLFFL 338
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 83-238 2.42e-09

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 59.13  E-value: 2.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  83 VAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRG 162
Cdd:cd17504   15 LSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPN--LPVLIAGRA 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 380797743 163 LVGIGEASYsTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLI 238
Cdd:cd17504   93 LQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLG-WRWIFWTAAPVAVLLAALV 166
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 83-481 2.79e-09

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 58.72  E-value: 2.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  83 VAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRG 162
Cdd:cd17478   15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPN--YWLLLLLVA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 163 LVGIGEASYSTIAPTIIGDLFTKNtRTLMLSVFYFAIPLGSGLGYITGSSVKQaagdwHWALRVSPVLGMITGTLILIL- 241
Cdd:cd17478   93 LAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVA-----LFGGLGLLILLIIPGLAVALLl 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 242 --VPATKRGHADQLGDQLKTRTSWLRDMKALIRnrsYVFSSLATSAVSFATGALgmwIPLYLHRAQVVQKTAETCNSPpc 319
Cdd:cd17478  167 lrLRPLKKPEAKKAAAKSSARSTLKGVWRALLL---LLIIVFLRSWVLSSLTTF---LPFYLVQRGYSLVFAGLLLSL-- 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 320 gakdSLIFGAITCFTGflgvvtGAGATRWCRLKtqradplVCAVGMLGSAIFICLIFVAaksSIVGAYICIFVGETLLFS 399
Cdd:cd17478  239 ----FLFAGAIGTLIG------GPLSDRFGRRR-------VIIASLLLAAPFLLLFLLT---PGIWSYILLVLAGFLLFA 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 400 NWAITadiLMYV--VIPTRRATAVALQSFTSHLLGDAGSPyLIGFISDLIrqstkdsplweflSLGYALMLCPFVVVLGG 477
Cdd:cd17478  299 SFPVT---VVLAqeLLPGNVGLASGLMMGLSFGLGGIGAP-VLGALADAF-------------GLESVLLILALLPLLGA 361


                 ....
gi 380797743 478 MFFL 481
Cdd:cd17478  362 LLAF 365
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
68-260 3.08e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 59.15  E-value: 3.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  68 ILSLGNVLNYLDRYTVAGVLL-DIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 146
Cdd:COG2211  232 LLLLAYLLFFLALALVAALLLyYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 147 SFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDL-------FTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAG- 218
Cdd:COG2211  312 FFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydewkTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGy 391

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 380797743 219 --------DWHWALRVS----PVLGMITGTLILILVPATKRGHAdQLGDQLKTR 260
Cdd:COG2211  392 vagaaqspSALTGIRLLffllPAVLLLLAALLLLFYPLTRERHA-EIRAELAAR 444
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 92-300 7.63e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 57.60  E-value: 7.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  92 QHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASY 171
Cdd:cd17489   24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS--VALLLVLRLIHGIGWGAF 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 172 STIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdwHWALRVSPVLGMITGTLILILVPATKRGHad 251
Cdd:cd17489  102 TTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG--FAVLFIVAAVLALLALLLVFLVKDPPPVA-- 177

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 380797743 252 qlgdqlKTRTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLY 300
Cdd:cd17489  178 ------AEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLY 220
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 88-242 8.18e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 57.59  E-value: 8.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  88 LDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIG 167
Cdd:cd17325  224 LYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATS--FWLLLLLLALLGLG 301

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 380797743 168 EASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILV 242
Cdd:cd17325  302 LGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLLLR 375
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 83-247 3.08e-08

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 55.74  E-value: 3.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  83 VAGVLLDIQQHFGVKDRGAG---LLQSVFICSFMVAAPIFGYLGDRFNRK--VILSCGIFFWSAVTFSSSfipqQYFWLL 157
Cdd:cd17360   16 ISGALLYIKDDLGEVVLSTGwqeLIVSSTVAGAAVGAAIGGWLNDRFGRRpcILLADALFTIGAIVMAAA----PNKEVL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 158 VLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTL 237
Cdd:cd17360   92 IVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPGGWRWMLGLAAVPAVLQFIG 171

                        170
                 ....*....|
gi 380797743 238 ILILvPATKR 247
Cdd:cd17360  172 LLFL-PESPR 180
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 114-301 4.89e-08

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 54.93  E-value: 4.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 114 VAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLS 193
Cdd:cd17329   50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS--PWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFS 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 194 VFYFAIPLGSGLGYITGSSVKQAAGDW-HWALRVSPVLGMItgtLILILVPATKRGHADQlgdqlkTRTSWLRDMKALIR 272
Cdd:cd17329  128 LLYWAINLGVAIGPLLGGLLLLYSFRLlFLAAAVLFLLAAL---VLLFLLPETRPKRRAA------EKTEILRGYKIVLR 198

                        170       180
                 ....*....|....*....|....*....
gi 380797743 273 NRSYVFSSLATSAVSFATGALGMWIPLYL 301
Cdd:cd17329  199 DRAFLLFLLASFLISLIYFQLESTLPVYV 227
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 85-211 9.02e-08

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 54.17  E-value: 9.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  85 GVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFwSAVTFSSSFIPQqyfwLLVLSRGLV 164
Cdd:cd17336   24 STITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSIL-MGLGCFLLALPH----FLFVGQFLL 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 380797743 165 GIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGS 211
Cdd:cd17336   99 GIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGS 145
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 82-473 1.33e-07

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 53.48  E-value: 1.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  82 TVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRK--VILSCGIFfwsaVTFSSSFIPQQYFWLLVL 159
Cdd:cd17333   14 LLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRrtLILGLLLI----SLALALIFATPSIYLFVV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 160 SRGLVGIGEASYSTIAPTIIGDLFtKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALrvspvlgMITGTLIL 239
Cdd:cd17333   90 LMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAY-------LIIGLIYL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 240 ILVPATKRGHADQLGD---QLKTRTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVqktaetcns 316
Cdd:cd17333  162 LLAILILLTLFPELPSarnPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHV--------- 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 317 ppcGAKDSLIFGAITCFTGFLGVVTGAGATRwcrlktqRADPLVCAVGMLGSAIFICLIFVAAKSSIVGAYICIFVGetL 396
Cdd:cd17333  233 ---SDGLAGYLLSGFWVGITIGRLLGGPISR-------RIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLG--L 300

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 380797743 397 LFSNWAITADILMYVVIPTRRATAVALQSfTSHLLGDAGSPYLIGFIsdlIRQSTKDSPLWEFLSLgYALMLCPFVV 473
Cdd:cd17333  301 FMAALFPTILSLGISNLPYAKGKGTSVLL-AAGSIGGAIIPFIMGFI---AEAVGIQTAMLLITIL-YAIIFVLALL 372
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 105-211 1.65e-07

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 52.97  E-value: 1.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 105 QSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFT 184
Cdd:cd17317   31 QTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSP--SYELFLVLRFLVGVTSAGIFTVGFVLGMEIVG 108

                         90       100       110
                 ....*....|....*....|....*....|.
gi 380797743 185 KNTRTLMLSVFYFAIPLG----SGLGYITGS 211
Cdd:cd17317  109 PKYRSFVGILFGLFWALGymllALLAYLIRD 139
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 101-241 2.10e-07

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 53.48  E-value: 2.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  101 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPqQYFWLLVLsRGLVGIGEASYSTIAPTIIG 180
Cdd:TIGR00898 129 VDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSP-NYTVFLVF-RLLVGMGIGGIWVQAVVLNT 206

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 380797743  181 DLFTKNTRTL--MLSVFYFAIplgsglGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILIL 241
Cdd:TIGR00898 207 EFLPKKQRAIvgTLIQVFFSL------GLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFV 263
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 71-483 2.43e-07

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 53.07  E-value: 2.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  71 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIp 150
Cdd:cd17371    6 LGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 151 qQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDwHWALRVSPVL 230
Cdd:cd17371   85 -QNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPP-EIAWRVLFLL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 231 GMITGTLILIL---VPATKRGHADQLGDQLKTRTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVV 307
Cdd:cd17371  163 GALPALLVLFIrrfVKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 308 QktaetcnsppcgAKDSLIFGAITCFTGFLG-VVTGAGATRWCRLKTqradplvCAVGMLGSAIFICLIFVAAKSSIVGA 386
Cdd:cd17371  243 S------------FEGSAGYLVVTILGGFLGyLAGGFLADRIGRRNN-------FALFALGSAISILLYFFLPLSPTLIL 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 387 YICIFVGETL--LFSNWAitadILMYVVIPTR-RATAVALQSFTSHLLGdAGSPYLIGFISDLIrqstkdsplweflSLG 463
Cdd:cd17371  304 ILGFPLGFFAsgPFSGMG----AYLTELFPTAvRATAQGFCYNVGRIIG-ALFPFLVGFLATSG-------------SLG 365

                        410       420
                 ....*....|....*....|...
gi 380797743 464 YALML---CPFVVVLGGMFFLAT 483
Cdd:cd17371  366 TAIAVfaaVYYIAGLVLALLLPE 388
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 69-245 2.44e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 52.59  E-value: 2.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  69 LSLGNVLNYLDRY--TVAGVLL-DIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFS 145
Cdd:cd17365    1 LALCFLIIVLDGFdlAVMGFVApALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 146 SSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALr 225
Cdd:cd17365   81 TAFAQS--VLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFG-WRSVF- 156

                        170       180
                 ....*....|....*....|
gi 380797743 226 vspVLGMITGTLILILVPAT 245
Cdd:cd17365  157 ---LLGGVPPLILLPLLRGT 173
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
113-501 2.52e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 52.98  E-value: 2.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 113 MVAAPIFGYLGDRFNRKV----------ILSCGIFFWsAVTFSSSFIPQQYFWLLVLSRGLVGIG----EASYSTIAPTI 178
Cdd:COG2211   60 AITDPLIGALSDRTRTRWgrrrpwiligAIPLALSFV-LLFTAPDLSPTGKLIYALVTYLLLGLAytlvNIPYSALGAEL 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 179 IGDlftKNTRTLMLSVFYFAIPLGSGLGYITGSS-VKQAAGDWHWALRVSPVLGMITGTL-ILILVPATKRGHADQlgdq 256
Cdd:COG2211  139 TPD---YEERTRLSSWRFAFAGLGGLLASVLPPPlVAAFGGDAALGYRLTALIFAVLGLLaFLLTFFGTKERPVPE---- 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 257 lKTRTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLhrAQVVQKTAETcnsppcgakdSLIFGAITCFTGF 336
Cdd:COG2211  212 -EEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYF--KYVLGLSAAL----------VGLLLALYFLAAL 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 337 LGV-VTGAGATRWCRLKTqradplvCAVGMLGSAIFICLIFVAAKSSIVGAYICIFVGE----TLLFSNWAITADILMYV 411
Cdd:COG2211  279 LGApLWPRLAKRFGKKKA-------FIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGiglgAILVLPWAMLADVVDYD 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 412 VIPT---RRATAVALQSFTSHlLGDAGSPYLIGFISDLIR-QSTKDSPLWEFLSLGYALMLCPFVVVLGGMFFLataLFF 487
Cdd:COG2211  352 EWKTgrrREGLYFGIFTFAIK-LGQALAGALAGLLLALFGyVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLL---LFY 427

                        410
                 ....*....|....
gi 380797743 488 LSDRAKAEQQVNQL 501
Cdd:COG2211  428 PLTRERHAEIRAEL 441
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 70-241 3.00e-07

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 52.58  E-value: 3.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  70 SLGNVLNYLDRYTVAGVLLDIQQHFGVKdrGAGLLQSVFICSFMVAAPI----FGYLGDRFNRKVILSCGIFFWSAVTFS 145
Cdd:cd17315    3 ALGGLLFGYDLGVINGALLYIAKDLGFG--LSTSLQGLVVSSLLLGAAIgslfGGPLADRFGRRKSLLIAAVLYVIGALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 146 SSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ-AAGDWHWAL 224
Cdd:cd17315   81 SALAPN--VWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLsPPGWWRLMF 158

                        170
                 ....*....|....*..
gi 380797743 225 RVSPVLGMITGTLILIL 241
Cdd:cd17315  159 ALAAVPALLQLLLMFFL 175
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 101-206 5.32e-07

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 51.81  E-value: 5.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 101 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFwSAVTFSSSFIpQQYFWLLVLSRGLVGIGeASYSTIAPTIIG 180
Cdd:cd17330   36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAG-SAVSYVLLGL-SRNLWLLFLARFLDGLT-GGNVSVAQAYIA 112

                         90       100
                 ....*....|....*....|....*.
gi 380797743 181 DLFTKNTRTLMLSVFYFAIPLGSGLG 206
Cdd:cd17330  113 DITDEEERAKAFGIISAAFGLGFILG 138
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 69-430 9.81e-07

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 51.02  E-value: 9.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  69 LSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSF 148
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 149 IPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSP 228
Cdd:cd17321   81 APS--LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFG-WRWIFLINV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 229 VLGMItgtlililvpatkrghadqlgdqlktrtswlrdmkALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQvvq 308
Cdd:cd17321  158 PIGLV-----------------------------------ALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVL--- 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 309 ktaetcNSPPCGAkdSLIFGAITCFTGFLGVVTGAGATRWCRLKTQRADPLVCAVGMLGSAIficLIFVAAKSSIVGAYI 388
Cdd:cd17321  200 ------GYSPLQA--GLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL---LGADSSVWLLLPGLV 268

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 380797743 389 CIFVGETLLfsnWAITADILMYVVIPTRRATAVALQSFTSHL 430
Cdd:cd17321  269 LLGLGLGLF---ATPLTNAALSSVPKEKAGAASGILNTARQL 307
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 71-242 1.26e-06

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 50.74  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  71 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP 150
Cdd:cd17312   10 LGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFST 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 151 QqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQaAGDWHWALRVSPVL 230
Cdd:cd17312   90 S--LWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLAS-YYGWRAAFLVPGIV 166

                        170
                 ....*....|..
gi 380797743 231 GMITGTLILILV 242
Cdd:cd17312  167 GLVVAIILFFFL 178
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 113-265 2.66e-06

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 49.88  E-value: 2.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 113 MVAAPIFGYLGDRFNRK-VILSCGIFF---WSAVTFSSSFipqqyfWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTR 188
Cdd:cd17358   55 LIGALLSGKLADRIGRKrTLLISAIPCilgWLLIAFAKDV------WMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVR 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 189 TLMLSVFYFAIPLGSGLGYITGSSVkqaagdwHWalRVSPVLGMI---TGTLILILVPAT-----KRGHADQLGDQLKtr 260
Cdd:cd17358  129 GALGSLNQLLVNIGILLGYVLGSFL-------PW--RTLALIGAIppvVFLILLFFIPESprwlaKKGREEEAEKSLQ-- 197


                 ....*
gi 380797743 261 tsWLR 265
Cdd:cd17358  198 --FLR 200
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
 101-241 3.58e-06

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 49.11  E-value: 3.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 101 AGLLQSVFiCSFMVAAPIF-GYLGDRF--NRKVILSCGIFFwsAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPT 177
Cdd:cd17346   42 AASIYGAY-TALVYLTPIIgGWLADKVlgARRTVFIGGILM--ALGYLLLALSPFSVSMLYLGLALIIVGNGLFKPNISS 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 380797743 178 IIGDLFTKN--TRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVlGMITGTLILIL 241
Cdd:cd17346  119 LVGKLYDENdpRRDSGFSIFYMGINLGAFLAPLLCGTLGDNYG-YHYGFGLAAV-GMLLGLLIFLL 182
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 83-247 8.57e-06

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 47.95  E-value: 8.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  83 VAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRK--VILSCGIFFWSAV--TFSSSFipqqyfWLLV 158
Cdd:cd17359   20 INGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRktLLISAVLFFISALgsAFSPNF------TIFI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 159 LSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGD-------WHWALRVSPVLG 231
Cdd:cd17359   94 IARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGAdwlgaegWRWMLGLEAIPA 173

                        170
                 ....*....|....*.
gi 380797743 232 MITGtLILILVPATKR 247
Cdd:cd17359  174 ILFL-LGMLFIPESPR 188
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
68-247 1.21e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 47.56  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  68 ILSLGNVLNYLDRYTVAGVLLDI-QQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 146
Cdd:COG2271  184 LLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALL 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 147 SFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRV 226
Cdd:COG2271  264 LLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLL 342

                        170       180
                 ....*....|....*....|.
gi 380797743 227 SPVLGMITGTLILILVPATKR 247
Cdd:COG2271  343 LAALALLAALLALLLLRETRK 363
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 105-222 1.67e-05

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 46.90  E-value: 1.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 105 QSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFT 184
Cdd:cd17374   41 QSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPT--FPVYCVLRFLAGFAVSGISINTLILGTEWTT 118

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 380797743 185 KNTRTLM--LSVFYFAIplgsglGYITGSSVKQAAGDWHW 222
Cdd:cd17374  119 PRHRALAitLTSCFFSI------GQMLLAGLAYAIRDWRL 152
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 92-206 2.85e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 46.38  E-value: 2.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  92 QHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFssSFIPQQYFWLLVLSRGLVGIGEASY 171
Cdd:cd17370  227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYL--GFALGSSLWLLLLGFILWGLYMGAQ 304

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 380797743 172 STIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLG 206
Cdd:cd17370  305 ESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLA 339
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 87-289 3.27e-05

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 46.03  E-value: 3.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  87 LLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGI 166
Cdd:cd17320   22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASS--IEQLLIARFLQGL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 167 GEASYSTIAPTIIGDLFTKNTRTLMLS----VFYFAIPLGSGLGyitgsSVKQAAGDWHWALRVSPVLGMITGTLILILV 242
Cdd:cd17320  100 GAAAGSVVARAIVRDLYSGAELAKIFSllmmILAIAPALAPLLG-----GLLLLFFGWRAIFVFLALLGLLLLLLVLLFL 174

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 380797743 243 PATKRGHADQLGDQLKtrtswLRDMKALIRNR---SYVFSSLATSAVSFA 289
Cdd:cd17320  175 PETLPEEKRKPLLSSL-----LRAYKRVLKNRrflGYALALGLSFAGLFA 219
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 67-233 4.64e-05

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 45.60  E-value: 4.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  67 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGiFFWSAV-TFS 145
Cdd:cd17372    2 AYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIIS-ALWTFYaGFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 146 SSFIPqQYFWLLVLsRGLVGIGEASYSTIApTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALR 225
Cdd:cd17372   81 SAFAP-NYMWLIIL-RCLVGLGLGGGPQLA-SWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLG-WRWLLA 156


                 ....*...
gi 380797743 226 VSPVLGMI 233
Cdd:cd17372  157 FSSVPSSL 164
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
 84-211 1.01e-04

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 44.65  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  84 AGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWS--AVTFSssfIPQqyfwLLVLSR 161
Cdd:cd17404   23 NSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIAlgSFLFS---LPH----FFILAQ 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 380797743 162 GLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGS 211
Cdd:cd17404   96 ILIGMGGTPIFTLGTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGG 145
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 68-243 1.64e-04

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 44.16  E-value: 1.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  68 ILSLGNVLNYLDRYTVA-GVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 146
Cdd:cd17327    9 LLCILYFLQYLDKSNISnAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 147 SFIpqQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGS--------GLGYITGSSVKQaag 218
Cdd:cd17327   89 AAV--KNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSifggllayGVFKILGVGGLA--- 163

                        170       180
                 ....*....|....*....|....*
gi 380797743 219 DWHWALRVSPVLGMITGTLILILVP 243
Cdd:cd17327  164 GWRWLFIIEGLITIIIGLVIFFWLP 188
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 102-247 2.71e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 43.40  E-value: 2.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 102 GLLQSVFICSFMVAAPIFGYLGDRFNRKVIL---SCGIFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTI 178
Cdd:cd17357   52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLlisNALLVVSSLLMFLSKSAK--SPELLIFGRFLVGIACGLSTGFVPMY 129

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 179 IGDLFTKNTRTLMLSVFYFAIPLGSGLGYITG-SSVKQAAGDWHWALrVSPVLGMITGTLILILVPATKR 247
Cdd:cd17357  130 LQEISPSELRGALGSLTQIGVTLGILLGQVFGlPSVLGTETLWPYLL-FFPGIPALLQLAALPFFPESPK 198
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 112-233 2.75e-04

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 43.26  E-value: 2.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 112 FMVAAPIFGYLGDRFNRKVILScGIFFWSA-VTFSSSFIPqQYFWLLVLsRGLVGIGEASYSTiAPTIIGDLFTKNTRTL 190
Cdd:cd17442   49 YMVFSILLGLLADRYGRWKILL-LSFVWGAyFSLLTSFAP-SYIWFVFL-RCMVGCGVSGHSQ-GLIIKTEFLPTKYRGY 124

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 380797743 191 ML---SVFYFAiplGSGLGYITGSSVKQAAGdWHWALRVSPVLGMI 233
Cdd:cd17442  125 MLplsQIFWLA---GSLLIIGLASVVIPTLG-WRWLIRFASIPGII 166
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 92-176 2.86e-04

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 43.34  E-value: 2.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  92 QHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFN-RKVILSCGIFFWSAVTFSSSFIPQQYFWLLVlsrgLVGIGEAS 170
Cdd:cd17335   25 KQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAQIFWLLLL----LVILGAFF 100


                 ....*.
gi 380797743 171 YSTIAP 176
Cdd:cd17335  101 SAPVVP 106
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 55-422 3.60e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 42.73  E-value: 3.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743   55 PASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSC 134
Cdd:TIGR00895   8 KQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLW 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  135 GIFFWSAVTFSSSFipQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVK 214
Cdd:TIGR00895  88 SILLFSVFTLLCAL--ATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  215 QAAGdWHWALRVSPVLGMITGTLILILVP----------------------ATKRGHADQLGDQLKTRTSWLRDMKALI- 271
Cdd:TIGR00895 166 PVFG-WRSLFYVGGIAPLLLLLLLMRFLPesidflvskrpetvrrivnaiaPQMQAEAQSALPEQKSTQGTKRSVFKALf 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  272 ---RNRSYVFSSLATSAVSFATGALGMWIPLYlhraqvvqkTAETCNSPpcgaKDSLIFGAITCFTGFLGVVTGAGAtrw 348
Cdd:TIGR00895 245 qgkTARITVLLWLLYFMLLVGVYFLTNWLPKL---------MVELGFSL----SLAATGGALFNFGGVIGSIIFGWL--- 308

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 380797743  349 crlkTQRADPLVCAVGMLGSAIFICLIFVAAKSSIVGAYICIFVGetlLFSNWAITADI-LMYVVIPTR-RATAVA 422
Cdd:TIGR00895 309 ----ADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAG---FFVNGGQSGLYaLMALFYPTAiRATGVG 377
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 82-301 3.71e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 42.95  E-value: 3.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  82 TVAGVLL-DIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKvilscGIFFWSAVTF-SSSFIP--QQYFWLL 157
Cdd:cd17503   13 TIVNVALpTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTR-----RLFLTALALFtLGSLLCglAPNLASL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 158 VLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMItgtl 237
Cdd:cd17503   88 IIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLS-WRWIFYINLPIGIL---- 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 380797743 238 ILILVPatkrghadqlgdqlktrtswLRDMKALiRNRSYVFSSLATSAVSFATGALGMWIPLYL 301
Cdd:cd17503  163 ALLLAP--------------------LLDLRLF-KDRNFTLGLLLSFLLGLGLFGAMFLLPLYL 205
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 64-240 3.87e-04

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 43.12  E-value: 3.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743   64 AAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGvKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRK--VILSCGIFFWSA 141
Cdd:pfam06609  44 ASFAAFSLNVCATYFVLQASASALPNILQDIG-QSENQGLFSTLWTMGQAVSILMMGRLTDRFGRRpfVIATHIIGLVGA 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  142 VTFSSSfipqQYFWLLVLSRGLVGIGeASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVkQAAGDWH 221
Cdd:pfam06609 123 IVGCTA----NKFNTLLAAMTLLGVA-AGPAGASPLFIGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRL-AIQGNWR 196

                         170
                  ....*....|....*....
gi 380797743  222 WALRVSPVLGMITGTLILI 240
Cdd:pfam06609 197 WIFYIYIIMSAIAVLLIII 215
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
87-289 4.54e-04

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 42.59  E-value: 4.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  87 LLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIpqQYFWLLVLSRGLVGI 166
Cdd:PRK11102  14 LPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALA--QTIDQLIYMRFLHGL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 167 GEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVPATk 246
Cdd:PRK11102  92 AAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFS-WHAIFWVLALAAILAAALVFFFIPET- 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 380797743 247 rgHADQLGDQLKTRTSwLRDMKALIRNRSyVFSSLATSAVSFA 289
Cdd:PRK11102 170 --LPKERRQPFHLRTT-IRNFASLFRHKR-VLGYMLASGFSFA 208
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 90-462 6.61e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 41.84  E-value: 6.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  90 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFipQQYFWLLVLSRGLVGIGea 169
Cdd:cd17475   22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL--VGSYPVLLVLLFLVGAG-- 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 170 sYSTIAPT---IIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILilvpatk 246
Cdd:cd17475   98 -YGSVQPGggrAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYG-WRAAFVVAGLVSILAAVLFW------- 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 247 RGHADQLGDQLKTRTS--WLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVqktaetcnSPPCGAkds 324
Cdd:cd17475  169 LFYREPPAASAATESAstLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGL--------SVVAAG--- 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 325 lIFGAITCFTGFLGVVTGAGATRwcRLKTQRADPLVCAVGMLGSAIFICLIFVAAKSSIVGAY-ICIFVGetLLFSNWAI 403
Cdd:cd17475  238 -ALLAVAQLGGALGRIGLGRVSD--RVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVlLLILLG--LFAIGWNG 312

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 404 TADILMYVVIPTRRA-TAVALqSFTSHLLGDAGSPYLIGFISDlirQSTKDSPLWEFLSL 462
Cdd:cd17475  313 LYLTLVAESAGPEQAgTALGL-ANTINFIGIAIGPPLFGLLVD---ATHSYAPAWLALAL 368
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 69-222 8.76e-04

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 41.40  E-value: 8.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  69 LSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRgAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFW---SAVTFS 145
Cdd:cd17502    1 LMLALFLAALDQTIVATALPTIVAEFGGLSL-VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFelgSLLCGL 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 380797743 146 SSFIPQqyfwlLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHW 222
Cdd:cd17502   80 APNMTM-----LIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLS-WRW 150
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
 90-211 1.20e-03

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 41.47  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  90 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWS--AVTFSssfIPQqyFWLLVLSRGLVGIG 167
Cdd:cd17403   30 IEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIMGigSLVFA---LPH--FTVFILAQLLHGAG 104

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 380797743 168 EASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGS 211
Cdd:cd17403  105 ATPLYTLGVTYLDENVSTKMSPLYIGIFYAMAILGPAIGYVLGG 148
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 114-258 1.42e-03

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 41.07  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 114 VAAPIFGYLGDRFNRKVILSCGIFFW---SAVTFSSSFIPQqyfwlLVLSRGLVGIGeASYSTIAPTIIGDLFTKNTRTL 190
Cdd:cd06179   47 VLGPIVGRLSDLFGRRWFFIGGNLLGvvgSIVAGTAKSVNM-----LIGGQALIGIG-AGTQGLGAAVASELVPNKYRGL 120

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 380797743 191 MLSVFYFAIPLGSGLG-YITGSSVKQAAGDWHWALRVSPVLGMITGTLILILV--PATKRGHADQLGDQLK 258
Cdd:cd06179  121 VQGVVNLVASPGSALGpLIAGALVEANAAGWRWIFYINAIFNALALILLFFFYhpPPRPQLHGSSTRQKLK 191
MFS_1 pfam07690
Major Facilitator Superfamily;
90-206 1.83e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.48  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743   90 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP-QQYFWLLVLSRGLVGIGE 168
Cdd:pfam07690 226 YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSlTLSSLWLLLALLLLGFGF 305

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 380797743  169 ASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLG 206
Cdd:pfam07690 306 GLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 66-240 2.76e-03

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 39.93  E-value: 2.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  66 AAILSLGNVLNYLDRYTVAGVL--LDIQQHFGVKDRGAGLLQSV--FICSFMVAAPIFG-----YLGDRFNRKVILSCGI 136
Cdd:cd17356    3 CAFVSLGGFLFGYDTGSISGILnmKSFQKYFADNTGTYYPSSSRqgLIVSIVNLGSFFGalissFLSDRIGRKKSIQIGC 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 137 FFWS-AVTFSSSFIPQQyfWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ 215
Cdd:cd17356   83 VIYIiGAIIQVAAIGKW--YQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHK 160

                        170       180
                 ....*....|....*....|....*
gi 380797743 216 AAGDWHWalRVSPVLGMITGTLILI 240
Cdd:cd17356  161 LDGSAQW--RIPLGLQIVWGLLLLI 183
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 59-169 3.74e-03

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 39.96  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743   59 GRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFF 138
Cdd:TIGR01299 162 GRFQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSV 241

                          90       100       110
                  ....*....|....*....|....*....|.
gi 380797743  139 WSAVTFSSSFIPQQYFWLLVLSRGLVGIGEA 169
Cdd:TIGR01299 242 NGFFAFFSSFVQGYGFFLFCRLLSGFGIGGA 272
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 101-213 4.48e-03

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 39.57  E-value: 4.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 101 AGLLQSVFICSFMVAAPIFGYLGDRFNRK-------VILSCGIFfwsAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYST 173
Cdd:cd17364   41 SGLVNAAALVGTIIGQLFFGFLGDRFGRKrvygvelIIMIIGTI---LSALSPGSTPLGVMGWLIFFRFLLGIGIGGDYP 117

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 380797743 174 IAPTIIGDLFTKNTRTLMLSVFYFAIplgsGLGYITGSSV 213
Cdd:cd17364  118 LSATIMSEYANKKRRGALIAAVFAMQ----GFGILAGAIV 153
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
 136-241 4.73e-03

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 39.22  E-value: 4.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  136 IFFWSAVtfsSSFIPQQYFWLLVLSRGLVGIGeasYSTIAPTI---IGDLFTKNT---RTLMLSVFYFAIPLGSGLGYIT 209
Cdd:pfam00854  17 LLALSAI---PSLRPPVHVALFFIGLALIALG---TGGIKPNVssfGGDQFEETDprrRSRFFSIFYFSINAGSLISTII 90

                          90       100       110
                  ....*....|....*....|....*....|..
gi 380797743  210 GSSVKQAAGdWHWALRVsPVLGMITGTLILIL 241
Cdd:pfam00854  91 TPYLQQNYG-YPLGFGL-PAVGMIIALLVFLL 120
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 101-210 6.39e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 38.75  E-value: 6.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 101 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFF----WSAVTFSSSFIpqqyfwLLVLSRGLVGIGEASySTIAP 176
Cdd:cd17390   33 IGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLtalgYVLLGFSTSLA------LLFLSRIPLGIFKHT-QSLCK 105

                         90       100       110
                 ....*....|....*....|....*....|....
gi 380797743 177 TIIGDLFTKNTRTLMLSVFYFAiplgSGLGYITG 210
Cdd:cd17390  106 AYLSDLVSEQERSRVLGRFNAA----SSLGFILG 135
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
 90-213 6.44e-03

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 38.98  E-value: 6.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743  90 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSS---FIPQQY-FWLLVLSRGLVG 165
Cdd:cd17460   29 IEKRFGLSSQTSGLLASFNEVGNTVLIVFVSYFGSRVHRPRFIGCGAILVSLAGFLMAlphFISEPYeYGILFLGQLLLG 108

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 380797743 166 IGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSV 213
Cdd:cd17460  109 IGGVPIQPFGISYIDDFASESNSPLYLGILFAVTVLGPGFGFMLGSAM 156
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 102-246 7.97e-03

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 38.49  E-value: 7.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797743 102 GLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGD 181
Cdd:cd17362   42 GLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPS--YPVLLVGRLIYGVGIGLAMHAAPVYIAE 119

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 380797743 182 LFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILVPATK 246
Cdd:cd17362  120 TSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVGGWRYMYGLAAPPALLLGIGMWFLPPSPR 184
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 101-164 8.91e-03

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 38.19  E-value: 8.91e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 380797743 101 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVIL----SCGIFFWSAVTFSS---SFIPQQYFWLLVLSRGLV 164
Cdd:cd17375   37 AKLIQPIFMLGVLLGAVIFGDIADRIGRRPVLwftsTGQFVFGIAVAFTFdyySFVIVRFLLAMVSSGYLV 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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