Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797163 1593 PDAPRNLQLSlPREAEGVIVgHWAPPIHTHGLIREYIVEYSRSGSKMW---ASQRAASNFTEINNLLVNTLYTVRVAAVT 1669
Cdd:cd00063     1 PSPPTNLRVT-DVTSTSVTL-SWTPPEDDGGPITGYVVEYREKGSGDWkevEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 380797163 1670 SRGIGNWSDSKCITT 1684
Cdd:cd00063    79 GGGESPPSESVTVTT 93

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 380797163 1267 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1301
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|.
gi 380797163 1315 QFRCENGHCIPNRWKCDRENDCGDWTDEKDC 1345
Cdd:cd00112     5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|..
gi 380797163 1182 NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHC 1213
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 380797163 1499 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETH-SNKTNTVLKVLKPDTTYQVKVQ 1570
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVR 75

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....
gi 380797163 1062 DTQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 1095
Cdd:cd00112     3 PNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 380797163 1413 CDRFEFECHQpKKCIPNWKRCDGHRDCQDGRDEANC 1448
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|....
gi 380797163   1455 TCMSREFQCEDGEaCIVLSERCDGFLDCSDESDE 1488
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33

Fibronectin type 3 domain [General function prediction only];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797163 1749 VGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAP--SLKAKAINQTAVECTWTGPRNVV---YGIFYATSFLDL 1823
Cdd:COG3401   196 GGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAptGLTATADTPGSVTLSWDPVTESDatgYRVYRSNSGDGP 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797163 1824 YRNPKSLTTSLHNKTViVSKDEQYLFLVRVVVpYQGPLSDY-VVVKMIPDSRLP--PRHLHVVHTGKTSVVIKWEspyDS 1900
Cdd:COG3401   276 FTKVATVTTTSYTDTG-LTNGTTYYYRVTAVD-AAGNESAPsNVVSVTTDLTPPaaPSGLTATAVGSSSITLSWT---AS 350

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797163 1901 PDQDLL-YAIAvkdliRKTDRSY---KVKSRNSTVEYTLNKLEPGGKYHIIVQ----LGNMSkDASIKITTVSLSAPDAL 1972
Cdd:COG3401   351 SDADVTgYNVY-----RSTSGGGtytKIAETVTTTSYTDTGLTPGTTYYYKVTavdaAGNES-APSEEVSATTASAASGE 424

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797163 1973 KIITENDHVLLFWKSLGLKEKHFNESRGYEIHMYDSAMNITAYLGNTTDNFFKISNLKMGHNYTFTVQARCLFGSQICGE 2052
Cdd:COG3401   425 SLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASS 504

                         330
                  ....*....|....*
gi 380797163 2053 PAILLYDELGSGADA 2067
Cdd:COG3401   505 VTNSVSVIGASAAAA 519

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20
                    ....*....|....*....|....*...
gi 380797163   1223 FVCKNRQqCLFHSMVCDGIIQCRDGSDE 1250
Cdd:smart00192    7 FQCDNGR-CIPSSWVCDGVDDCGDGSDE 33

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797163   1691 PRPDIHIDSYGENYLSFTLTMESDIKVNGYVVNLFWAFDTHKQERRTLNFRGSILSHKVGNLTAHTSYEISAWAKTDLGD 1770
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82

                    .
gi 380797163   1771 S 1771
Cdd:smart00060   83 G 83

Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797163    75 SDVYVSYDYGKSFKKISEKLNfgvgnrsEAVIAQFYHSPADNKRYIFADAyAQYLWITFDFCNTLQGFSIPFRAA----D 150
Cdd:pfam15902    1 SEVYRSHDYGKTWKKVKDVPD-------GEAILAIYPHPYDNDRAYLLTD-GKKHYYTTDRGKTFRSFKLPFPPNlfgpP 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797163   151 LLLHSKASNLLLGFDR----SHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHEP------SGYSTVF 220
Cdd:pfam15902   73 LSFHPKDPDWLIWYGGkcfsGDCHSVAYYSTDGGKSWKLLLEYVRRCEWAVSSKADENLIFCEVYENesgnadDVKLRLV 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797163   221 RSTDFFQSREnqEVILEEVRDFQLRDKYMFATKVvhllgSQQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQ 300
Cdd:pfam15902  153 SSDDFFKSDK--VLFDDGVVGFAVVGEFIVVAVK-----SENTSELALYVSYDGKTFARAQFPHVLEQQAYTVLESSTHS 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797163   301 VFVCVSHSNNR--TNLYISEAEGLKFSLSLENVlyyspggagsdtlvrYFANEPFADFHRVEGLQGVYIA-TLIN----G 373
Cdd:pfam15902  226 IFLHVTTSSDNpyGSLYKSNSNGTYFVLSLENV---------------NRNERGYVDFEKVAGLEGVYLAnVVSNaeevG 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797163   374 SMNEENMRSVITFDKGGTWEFLQAPAFTGYGeKINCELSQGCSLHLAQRLSQLLSLQlrrMPILSKESAPGLIIATGSVG 453
Cdd:pfam15902  291 KGADKKLKTKITFNDGGTWQPLKPPDKDSEY-KCSGKGLEKCSLHLHGYTERLVNIG---RDTFSSPSAPGLIMGVGNVG 366

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 380797163   454 KNLASKT--NVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQ-GMETNELKYSTNEGETWKTFIFSEKPVFVYGL 528
Cdd:pfam15902  367 DSLGPYEdaDTFISRDGGITWKEVLKGPHKWEFGDQGSIIVAVKDeGDPTDEISYSLDEGKTWETYKFADEKIRVLDL 444

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 380797163  1099 QCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1134
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 380797163 1100 CRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1134
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 380797163  1140 TCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEdpVNC 1177
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE--ENC 37

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 380797163 1020 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 1054
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 380797163 1141 CEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDpvNC 1177
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE--NC 35

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 380797163  1267 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1301
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|..
gi 380797163   1267 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE 1298
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|
gi 380797163   1181 CNGFRCPNGTCIPSSKHCDGLRDCSDGSDE 1210
Cdd:smart00192    4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Fibronectin type III domain;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797163  1594 DAPRNLQLSlPREAEGVIVgHWAPPIHTHGLIREYIVEYSRSGS-KMWASQRAASN--FTEINNLLVNTLYTVRVAAVTS 1670
Cdd:pfam00041    1 SAPSNLTVT-DVTSTSLTV-SWTPPPDGNGPITGYEVEYRPKNSgEPWNEITVPGTttSVTLTGLKPGTEYEVRVQAVNG 78

                   ....*..
gi 380797163  1671 RGIGNWS 1677
Cdd:pfam00041   79 GGEGPPS 85

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 380797163  1182 NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHC 1213
Cdd:pfam00057    6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Fibronectin type 3 domain [General function prediction only];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797163 1484 DESDEKACSDELTVY-------KVQNLQWTADFSGDVTLTWMRPKKMPSAScvYNVYYRVVGESIWKTLEThSNKTNTVL 1556
Cdd:COG3401   213 DTGGESAPSNEVSVTtpttppsAPTGLTATADTPGSVTLSWDPVTESDATG--YRVYRSNSGDGPFTKVAT-VTTTSYTD 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797163 1557 KVLKPDTTYQVKVqvqclsKAHNTN-------DFVTLRTPEGLPDAPRNLQLSLPrEAEGVIVGhWAPPihTHGLIREYI 1629
Cdd:COG3401   290 TGLTNGTTYYYRV------TAVDAAgnesapsNVVSVTTDLTPPAAPSGLTATAV-GSSSITLS-WTAS--SDADVTGYN 359

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 380797163 1630 VEYSRSGSKMW---ASQRAASNFTeINNLLVNTLYTVRVAAVTSRGI 1673
Cdd:COG3401   360 VYRSTSGGGTYtkiAETVTTTSYT-DTGLTPGTTYYYKVTAVDAAGN 405

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 380797163   1500 VQNLQWTADFSGDVTLTWMRPKKMPSAScvYNVYYRVVGESI---WKTLETHSNKTNTVLKVLKPDTTYQVKVQV 1571
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDGITG--YIVGYRVEYREEgseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....
gi 380797163 1062 DTQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 1095
Cdd:cd00112     3 PNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 380797163 1876 PPRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAIAVKDLIRKTDRSYKVKSRNSTvEYTLNKLEPGGKYHIIVQ 1949
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET-SYTLTGLKPGTEYEFRVR 75

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 380797163 1413 CDRFEFECHQpKKCIPNWKRCDGHRDCQDGRDEANC 1448
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 380797163    855 YRLVSEDVKWPNGISVD--DQWIYWTDAYLNCIERITFSGQQR 895
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDwiEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|....
gi 380797163   1455 TCMSREFQCEDGEaCIVLSERCDGFLDCSDESDE 1488
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33

Fibronectin type III domain;

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 380797163  1499 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVG-ESIWKTLETHSNKTNTVLKVLKPDTTYQVKVQ 1570
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNsGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 380797163  1412 RCDRFEFECHQpKKCIPNWKRCDGHRDCQDGRDEANC 1448
Cdd:pfam00057    2 TCSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37

Fibronectin type 3 domain [General function prediction only];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797163 1749 VGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAP--SLKAKAINQTAVECTWTGPRNVV---YGIFYATSFLDL 1823
Cdd:COG3401   196 GGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAptGLTATADTPGSVTLSWDPVTESDatgYRVYRSNSGDGP 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797163 1824 YRNPKSLTTSLHNKTViVSKDEQYLFLVRVVVpYQGPLSDY-VVVKMIPDSRLP--PRHLHVVHTGKTSVVIKWEspyDS 1900
Cdd:COG3401   276 FTKVATVTTTSYTDTG-LTNGTTYYYRVTAVD-AAGNESAPsNVVSVTTDLTPPaaPSGLTATAVGSSSITLSWT---AS 350

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797163 1901 PDQDLL-YAIAvkdliRKTDRSY---KVKSRNSTVEYTLNKLEPGGKYHIIVQ----LGNMSkDASIKITTVSLSAPDAL 1972
Cdd:COG3401   351 SDADVTgYNVY-----RSTSGGGtytKIAETVTTTSYTDTGLTPGTTYYYKVTavdaAGNES-APSEEVSATTASAASGE 424

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 380797163 1973 KIITENDHVLLFWKSLGLKEKHFNESRGYEIHMYDSAMNITAYLGNTTDNFFKISNLKMGHNYTFTVQARCLFGSQICGE 2052
Cdd:COG3401   425 SLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASS 504

                         330
                  ....*....|....*
gi 380797163 2053 PAILLYDELGSGADA 2067
Cdd:COG3401   505 VTNSVSVIGASAAAA 519

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|....
gi 380797163   1412 RCDRFEFECHqPKKCIPNWKRCDGHRDCQDGRDE 1445
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33