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Conserved domains on  [gi|375755393|gb|AFA76172|]
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transcriptional regulator, arsR family (plasmid) [Gordonia polyisoprenivorans VH2]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 16677510)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR_Rv2640c_fam NF041413
Rv2640c family ArsR-like transcriptional regulator; Mycobacterium tuberculosis has several ...
 1-121 2.81e-74

Rv2640c family ArsR-like transcriptional regulator; Mycobacterium tuberculosis has several ArsR-related transcriptional regulators, including Rv2640c, a member of this family, and Rv2642, encoded nearby. Members of the Rv2640c family have two invariant CC motifs, one at (or a single amino acid away from) the C-terminus.


:

Pssm-ID: 469304  Cd Length: 118  Bit Score: 216.05  E-value: 2.81e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375755393   1 MPKTLPMVDISAPICCAPVSSGPLNDGDALEIALRLKALADPVRIKLVSMLLTDEAGEgVCTCDLATAVGLTEATTSHHL 80
Cdd:NF041413   1 MPKALPVIDMSAPVCCAPVAAGPMSDDDALEIALRLKALADPVRVKLMSLLLTADDGE-VCTGDLAAAVGLSESTVSHHL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 375755393  81 GQLRKAGMVVGQRRGMNVYYRARPESLQALCAVLGasTGCC 121
Cdd:NF041413  80 GQLRKAGLVESERRGMNVYHRARPDALQALCGVLD--PNCC 118
 
Name Accession Description Interval E-value
ArsR_Rv2640c_fam NF041413
Rv2640c family ArsR-like transcriptional regulator; Mycobacterium tuberculosis has several ...
 1-121 2.81e-74

Rv2640c family ArsR-like transcriptional regulator; Mycobacterium tuberculosis has several ArsR-related transcriptional regulators, including Rv2640c, a member of this family, and Rv2642, encoded nearby. Members of the Rv2640c family have two invariant CC motifs, one at (or a single amino acid away from) the C-terminus.


Pssm-ID: 469304  Cd Length: 118  Bit Score: 216.05  E-value: 2.81e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375755393   1 MPKTLPMVDISAPICCAPVSSGPLNDGDALEIALRLKALADPVRIKLVSMLLTDEAGEgVCTCDLATAVGLTEATTSHHL 80
Cdd:NF041413   1 MPKALPVIDMSAPVCCAPVAAGPMSDDDALEIALRLKALADPVRVKLMSLLLTADDGE-VCTGDLAAAVGLSESTVSHHL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 375755393  81 GQLRKAGMVVGQRRGMNVYYRARPESLQALCAVLGasTGCC 121
Cdd:NF041413  80 GQLRKAGLVESERRGMNVYHRARPDALQALCGVLD--PNCC 118
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
25-114 2.78e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 91.10  E-value: 2.78e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375755393  25 NDGDALEIALRLKALADPVRIKLVSMLLTDEAgegvCTCDLATAVGLTEATTSHHLGQLRKAGMVVGQRRGMNVYYRARP 104
Cdd:COG0640    3 ETKELEELAELFKALADPTRLRILRLLAEGEL----CVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLAD 78

                         90
                 ....*....|
gi 375755393 105 ESLQALCAVL 114
Cdd:COG0640   79 EALAELLEWL 88
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 32-111 3.13e-23

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 85.59  E-value: 3.13e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375755393  32 IALRLKALADPVRIKLVSMLLTDEAgegvCTCDLATAVGLTEATTSHHLGQLRKAGMVVGQRRGMNVYYRARPESLQALC 111
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGEL----CVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 36-104 4.45e-17

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 70.02  E-value: 4.45e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 375755393  36 LKALADPVRIKLVSMLLTDEAgegvCTCDLATAVGLTEATTSHHLGQLRKAGMVVGQRRGMNVYYRARP 104
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPL----TVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
46-114 5.05e-14

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 61.84  E-value: 5.05e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 375755393    46 KLVSMLltdeAGEGVCTCDLATAVGLTEATTSHHLGQLRKAGMVVGQRRGMNVYYRARPESLQALCAVL 114
Cdd:smart00418   1 KILKLL----AEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 36-101 2.21e-13

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 60.50  E-value: 2.21e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375755393  36 LKALADPVRIKLVSML----LTdeAGEgvctcdLATAVGLTEATTSHHLGQLRKAGMVVGQRRGMNVYYR 101
Cdd:NF033789   2 FKALSDPTRREILELLkegdMT--AGE------IAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYS 63
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 41-89 7.10e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 53.22  E-value: 7.10e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 375755393   41 DPVRIKLVSMLLTDEAgegvCTCDLATAVGLTEATTSHHLGQLRKAGMV 89
Cdd:pfam01022   1 DPTRLKILKLLAEGEL----CVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 37-104 4.89e-09

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 50.20  E-value: 4.89e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 375755393  37 KALADPVRIKLVsmLLTDEAGEgVCTCDLATAVGLTEATTSHHLGQLRKAGMVVGQRRGMNVYYRARP 104
Cdd:PRK10141  11 KILSDETRLGIV--LLLRESGE-LCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSP 75
 
Name Accession Description Interval E-value
ArsR_Rv2640c_fam NF041413
Rv2640c family ArsR-like transcriptional regulator; Mycobacterium tuberculosis has several ...
 1-121 2.81e-74

Rv2640c family ArsR-like transcriptional regulator; Mycobacterium tuberculosis has several ArsR-related transcriptional regulators, including Rv2640c, a member of this family, and Rv2642, encoded nearby. Members of the Rv2640c family have two invariant CC motifs, one at (or a single amino acid away from) the C-terminus.


Pssm-ID: 469304  Cd Length: 118  Bit Score: 216.05  E-value: 2.81e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375755393   1 MPKTLPMVDISAPICCAPVSSGPLNDGDALEIALRLKALADPVRIKLVSMLLTDEAGEgVCTCDLATAVGLTEATTSHHL 80
Cdd:NF041413   1 MPKALPVIDMSAPVCCAPVAAGPMSDDDALEIALRLKALADPVRVKLMSLLLTADDGE-VCTGDLAAAVGLSESTVSHHL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 375755393  81 GQLRKAGMVVGQRRGMNVYYRARPESLQALCAVLGasTGCC 121
Cdd:NF041413  80 GQLRKAGLVESERRGMNVYHRARPDALQALCGVLD--PNCC 118
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
25-114 2.78e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 91.10  E-value: 2.78e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375755393  25 NDGDALEIALRLKALADPVRIKLVSMLLTDEAgegvCTCDLATAVGLTEATTSHHLGQLRKAGMVVGQRRGMNVYYRARP 104
Cdd:COG0640    3 ETKELEELAELFKALADPTRLRILRLLAEGEL----CVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLAD 78

                         90
                 ....*....|
gi 375755393 105 ESLQALCAVL 114
Cdd:COG0640   79 EALAELLEWL 88
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 32-111 3.13e-23

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 85.59  E-value: 3.13e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375755393  32 IALRLKALADPVRIKLVSMLLTDEAgegvCTCDLATAVGLTEATTSHHLGQLRKAGMVVGQRRGMNVYYRARPESLQALC 111
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGEL----CVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 36-104 4.45e-17

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 70.02  E-value: 4.45e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 375755393  36 LKALADPVRIKLVSMLLTDEAgegvCTCDLATAVGLTEATTSHHLGQLRKAGMVVGQRRGMNVYYRARP 104
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPL----TVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
46-114 5.05e-14

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 61.84  E-value: 5.05e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 375755393    46 KLVSMLltdeAGEGVCTCDLATAVGLTEATTSHHLGQLRKAGMVVGQRRGMNVYYRARPESLQALCAVL 114
Cdd:smart00418   1 KILKLL----AEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 36-101 2.21e-13

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 60.50  E-value: 2.21e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375755393  36 LKALADPVRIKLVSML----LTdeAGEgvctcdLATAVGLTEATTSHHLGQLRKAGMVVGQRRGMNVYYR 101
Cdd:NF033789   2 FKALSDPTRREILELLkegdMT--AGE------IAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYS 63
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 41-89 7.10e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 53.22  E-value: 7.10e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 375755393   41 DPVRIKLVSMLLTDEAgegvCTCDLATAVGLTEATTSHHLGQLRKAGMV 89
Cdd:pfam01022   1 DPTRLKILKLLAEGEL----CVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
24-107 2.82e-10

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 53.04  E-value: 2.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375755393  24 LNDGDALEIalrLKALADPVRIKLVSMLLTDEAGEGvctcDLATAVGLTEATTSHHLGQLRKAGMVVGQ----RRGMNVY 99
Cdd:COG4189    4 LDDEESLEV---LKALASETRLRILRLLAEEPLNVN----ELAEALGLPKSTVSYHIRKLEEAGLIRTEykpgKRGRQKI 76


                 ....*...
gi 375755393 100 YRARPESL 107
Cdd:COG4189   77 CYLRVDKI 84
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 37-104 4.89e-09

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 50.20  E-value: 4.89e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 375755393  37 KALADPVRIKLVsmLLTDEAGEgVCTCDLATAVGLTEATTSHHLGQLRKAGMVVGQRRGMNVYYRARP 104
Cdd:PRK10141  11 KILSDETRLGIV--LLLRESGE-LCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSP 75
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 33-95 4.96e-09

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 48.69  E-value: 4.96e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 375755393   33 ALRLKALADPVRIKLVSMLLTDEageGVCTCDLATAVGLTEATTSHHLGQLRKAGMVVGQRRG 95
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDE---PLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
28-107 2.74e-08

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 49.11  E-value: 2.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375755393  28 DALEIALrLKALADPVRIKLVSMLLTDEageGVCTCDLATAVGLTEATTSHHLGQLRKAGMVVGQRRGMNVYYRARPESL 107
Cdd:COG3398   84 SEEEKKI-LAYLRRETPRRILLYLLENP---GATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPPER 159
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
28-108 1.23e-07

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 46.57  E-value: 1.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375755393  28 DALEIALRLKALADPVRIKLVSMLLTDE--AGEgvctcdLATAVGLTEATTSHHLGQLRKAGMVVGQRRG------MNvY 99
Cdd:COG1777    3 DDEDLDRLLDALGNPTRRRILALLSEEPayVSE------LARELGVSRQAVYKHLRKLEEAGLVESYREGredgraRK-Y 75


                 ....*....
gi 375755393 100 YRARPESLQ 108
Cdd:COG1777   76 YRLSAFRLE 84
FaeA pfam04703
FaeA-like protein; This family represents a number of fimbrial protein transcription ...
 55-101 3.01e-03

FaeA-like protein; This family represents a number of fimbrial protein transcription regulators found in Gram-negative bacteria. These proteins are thought to facilitate binding of the leucine-rich regulatory protein to regulatory elements, possibly by inhibiting deoxyadenosine methylation of these elements by deoxyadenosine methylase.


Pssm-ID: 398397  Cd Length: 61  Bit Score: 33.60  E-value: 3.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 375755393   55 EAGEGVCTCDLATAVGLTEATTSHHLGQLRKAGMV--VGQRRGMNVYYR 101
Cdd:pfam04703  11 SIGAPCKTREIADALGLSAYQARYYLMQLEKEGKIkrSPLRRGASTLWE 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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