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Conserved domains on  [gi|374109759|gb|AEY98664|]
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FAGL154Wp [Eremothecium gossypii FDAG1]

Protein Classification

CDC37_N and CDC37_M domain-containing protein( domain architecture ID 10660768)

protein containing domains CDC37_N, CDC37_M, and CDC37_C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDC37_N smart01071
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 2-183 1.07e-65

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


:

Pssm-ID: 198139 [Multi-domain]  Cd Length: 154  Bit Score: 208.81  E-value: 1.07e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374109759     2 AIDYSKWDKIEISDDSDIEVHPNVDKRSFIRWKQQSIHEQREKRKQDIRNLEFQIEMYGHLNKRVDKLMEALSDRELvdr 81
Cdd:smart01071   1 PIDYSKWDKIELSDDSDIEVHPNVDKKSFIRWKQRDIHQARVERMEEIKNLKYELIMNDHLNKRIDKLLKGLREEEL--- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374109759    82 ervtrflnenfdktekgsgenvDPDMPPYNEMVEDLFEQLERNAAEEKKDPKDgtvLREQMQKHREKIRTVTAEARTKLD 161
Cdd:smart01071  78 ----------------------SPETPTYNEMLAELQDQLKKELEEANGDSEG---LLEELKKHRDKLKKEQKELRKKLD 132

                          170       180
                   ....*....|....*....|..
gi 374109759   162 ELYKEKAMHISSEDIHTGFDRS 183
Cdd:smart01071 133 ELEKEEKKKIWSVDTHTGFDKS 154
CDC37_M smart01070
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 202-360 5.45e-50

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 whose function is unclear.


:

Pssm-ID: 215010  Cd Length: 155  Bit Score: 167.94  E-value: 5.45e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374109759   202 KPDQAALPDSLKLVPTDFIDFKDDPMKLAPETEQFGSVPVGNYKASEAYLLDHVSILSEQQKDALMMQAFEYQLAGDEKK 281
Cdd:smart01070   2 ETTSSKNPPSAPSEEEDEIDDKDFVLKLEPATKKFGMIPAGDYDDSQKFLSEHPHIVSEETADALVMWAFDLELEGKEAL 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 374109759   282 AYQVIHQSELMSYIREiyamkkIPHLNAEELKEVIRVFFQKVFynTNNKMGKSSFLESVQSKFKHVTERCKVLANEQAD 360
Cdd:smart01070  82 MEQVAHQAILMQYILE------LAKSLKVDPRNCVRLFFQKIK--TPSHPAKEGFLEDVQSEFEHIKTRVRIIAQEQAE 152
CDC37_C pfam08564
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 383-463 9.23e-30

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37 pfam03234.


:

Pssm-ID: 430077  Cd Length: 87  Bit Score: 111.65  E-value: 9.23e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374109759  383 NLPDAQSKDPKEIQKVAAFNKLPKTMQDAVKTQKLDAINEVFAEMSIEEAEAILEIFNEGEIIGVNALL------EGEEE 456
Cdd:pfam08564   1 NLPDAGSEDPEEQKAVEIFESLPPEMQKALKTKSLDEVNKVLGKMPVEEAEEIVELFGEAGILGVEALLvdatteEGEKE 80


                  ....*..
gi 374109759  457 FKELQEH 463
Cdd:pfam08564  81 FKELQEE 87
 
Name Accession Description Interval E-value
CDC37_N smart01071
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 2-183 1.07e-65

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 198139 [Multi-domain]  Cd Length: 154  Bit Score: 208.81  E-value: 1.07e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374109759     2 AIDYSKWDKIEISDDSDIEVHPNVDKRSFIRWKQQSIHEQREKRKQDIRNLEFQIEMYGHLNKRVDKLMEALSDRELvdr 81
Cdd:smart01071   1 PIDYSKWDKIELSDDSDIEVHPNVDKKSFIRWKQRDIHQARVERMEEIKNLKYELIMNDHLNKRIDKLLKGLREEEL--- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374109759    82 ervtrflnenfdktekgsgenvDPDMPPYNEMVEDLFEQLERNAAEEKKDPKDgtvLREQMQKHREKIRTVTAEARTKLD 161
Cdd:smart01071  78 ----------------------SPETPTYNEMLAELQDQLKKELEEANGDSEG---LLEELKKHRDKLKKEQKELRKKLD 132

                          170       180
                   ....*....|....*....|..
gi 374109759   162 ELYKEKAMHISSEDIHTGFDRS 183
Cdd:smart01071 133 ELEKEEKKKIWSVDTHTGFDKS 154
CDC37_N pfam03234
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 7-127 2.29e-52

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain pfam08565. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 427208 [Multi-domain]  Cd Length: 124  Bit Score: 173.18  E-value: 2.29e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374109759    7 KWDKIEISDDSDIEVHPNVDKRSFIRWKQQSIHEQREKRKQDIRNLEFQIEMYGHLNKRVDKLMEALSDRELVDRERVTR 86
Cdd:pfam03234   1 KWDALELSDDSDIEVHPNVDKRSFIRWKQRDIHEKREQRKAEIKTLKYERIMNDGLLKRIDKLLTALKKHGVESDEVVFQ 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 374109759   87 FLNENF-DKTEKGSGENVDP--DMPPYNEMVEDLFEQLERNAAE 127
Cdd:pfam03234  81 ALMETAgDKNEKDDGPPARPeeNQPTYDEMLESLLDQIKEELKE 124
CDC37_M smart01070
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 202-360 5.45e-50

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 whose function is unclear.


Pssm-ID: 215010  Cd Length: 155  Bit Score: 167.94  E-value: 5.45e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374109759   202 KPDQAALPDSLKLVPTDFIDFKDDPMKLAPETEQFGSVPVGNYKASEAYLLDHVSILSEQQKDALMMQAFEYQLAGDEKK 281
Cdd:smart01070   2 ETTSSKNPPSAPSEEEDEIDDKDFVLKLEPATKKFGMIPAGDYDDSQKFLSEHPHIVSEETADALVMWAFDLELEGKEAL 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 374109759   282 AYQVIHQSELMSYIREiyamkkIPHLNAEELKEVIRVFFQKVFynTNNKMGKSSFLESVQSKFKHVTERCKVLANEQAD 360
Cdd:smart01070  82 MEQVAHQAILMQYILE------LAKSLKVDPRNCVRLFFQKIK--TPSHPAKEGFLEDVQSEFEHIKTRVRIIAQEQAE 152
CDC37_M pfam08565
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 235-360 2.94e-45

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain pfam03234, which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 pfam08564 whose function is unclear.


Pssm-ID: 430078  Cd Length: 113  Bit Score: 153.89  E-value: 2.94e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374109759  235 QFGSVPVGNYKASEAYLLDHVSILSEQQKDALMMQAFEYQLAGDEKKAYQVIHQSELMSYIREIyamkkiphlnaEELKE 314
Cdd:pfam08565   1 KFAKIPSGDYKASEQFLLKHPEILSEQQKDALLMEAFDAQLEGKTKYARQCVHQSLLLQYCRQL-----------DGRIN 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 374109759  315 VIRVFFQKVfyNTNNKMGKSSFLESVQSKFKHVTERCKVLANEQAD 360
Cdd:pfam08565  70 GVKLFFKRI--TTKDHQAKKLFLDDVQSTYNHIKTRAEEIKQEQAE 113
CDC37_C pfam08564
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 383-463 9.23e-30

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37 pfam03234.


Pssm-ID: 430077  Cd Length: 87  Bit Score: 111.65  E-value: 9.23e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374109759  383 NLPDAQSKDPKEIQKVAAFNKLPKTMQDAVKTQKLDAINEVFAEMSIEEAEAILEIFNEGEIIGVNALL------EGEEE 456
Cdd:pfam08564   1 NLPDAGSEDPEEQKAVEIFESLPPEMQKALKTKSLDEVNKVLGKMPVEEAEEIVELFGEAGILGVEALLvdatteEGEKE 80


                  ....*..
gi 374109759  457 FKELQEH 463
Cdd:pfam08564  81 FKELQEE 87
CDC37_C smart01069
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 383-480 1.64e-26

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37.


Pssm-ID: 215009  Cd Length: 93  Bit Score: 102.86  E-value: 1.64e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374109759   383 NLPDAQSKDPKEIqkvaaFNKLPKTMQDAVKTQKLDAINEVFAEMSIEEAEAILEIFNEGEIIGVNALLEGEEEFKELQE 462
Cdd:smart01069   1 NLPGGLSLDPEEV-----FESLPPELQKAFETKDLDMLNKVLAKMPVEEAEYHLERCIESGLWGVPNAIEDETEFKELQE 75

                           90
                   ....*....|....*...
gi 374109759   463 HYNQEKNMEQLSIGEVDG 480
Cdd:smart01069  76 QYEVEEEAEKEDEEEEDD 93
 
Name Accession Description Interval E-value
CDC37_N smart01071
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 2-183 1.07e-65

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 198139 [Multi-domain]  Cd Length: 154  Bit Score: 208.81  E-value: 1.07e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374109759     2 AIDYSKWDKIEISDDSDIEVHPNVDKRSFIRWKQQSIHEQREKRKQDIRNLEFQIEMYGHLNKRVDKLMEALSDRELvdr 81
Cdd:smart01071   1 PIDYSKWDKIELSDDSDIEVHPNVDKKSFIRWKQRDIHQARVERMEEIKNLKYELIMNDHLNKRIDKLLKGLREEEL--- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374109759    82 ervtrflnenfdktekgsgenvDPDMPPYNEMVEDLFEQLERNAAEEKKDPKDgtvLREQMQKHREKIRTVTAEARTKLD 161
Cdd:smart01071  78 ----------------------SPETPTYNEMLAELQDQLKKELEEANGDSEG---LLEELKKHRDKLKKEQKELRKKLD 132

                          170       180
                   ....*....|....*....|..
gi 374109759   162 ELYKEKAMHISSEDIHTGFDRS 183
Cdd:smart01071 133 ELEKEEKKKIWSVDTHTGFDKS 154
CDC37_N pfam03234
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 7-127 2.29e-52

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain pfam08565. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 427208 [Multi-domain]  Cd Length: 124  Bit Score: 173.18  E-value: 2.29e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374109759    7 KWDKIEISDDSDIEVHPNVDKRSFIRWKQQSIHEQREKRKQDIRNLEFQIEMYGHLNKRVDKLMEALSDRELVDRERVTR 86
Cdd:pfam03234   1 KWDALELSDDSDIEVHPNVDKRSFIRWKQRDIHEKREQRKAEIKTLKYERIMNDGLLKRIDKLLTALKKHGVESDEVVFQ 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 374109759   87 FLNENF-DKTEKGSGENVDP--DMPPYNEMVEDLFEQLERNAAE 127
Cdd:pfam03234  81 ALMETAgDKNEKDDGPPARPeeNQPTYDEMLESLLDQIKEELKE 124
CDC37_M smart01070
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 202-360 5.45e-50

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 whose function is unclear.


Pssm-ID: 215010  Cd Length: 155  Bit Score: 167.94  E-value: 5.45e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374109759   202 KPDQAALPDSLKLVPTDFIDFKDDPMKLAPETEQFGSVPVGNYKASEAYLLDHVSILSEQQKDALMMQAFEYQLAGDEKK 281
Cdd:smart01070   2 ETTSSKNPPSAPSEEEDEIDDKDFVLKLEPATKKFGMIPAGDYDDSQKFLSEHPHIVSEETADALVMWAFDLELEGKEAL 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 374109759   282 AYQVIHQSELMSYIREiyamkkIPHLNAEELKEVIRVFFQKVFynTNNKMGKSSFLESVQSKFKHVTERCKVLANEQAD 360
Cdd:smart01070  82 MEQVAHQAILMQYILE------LAKSLKVDPRNCVRLFFQKIK--TPSHPAKEGFLEDVQSEFEHIKTRVRIIAQEQAE 152
CDC37_M pfam08565
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 235-360 2.94e-45

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain pfam03234, which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 pfam08564 whose function is unclear.


Pssm-ID: 430078  Cd Length: 113  Bit Score: 153.89  E-value: 2.94e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374109759  235 QFGSVPVGNYKASEAYLLDHVSILSEQQKDALMMQAFEYQLAGDEKKAYQVIHQSELMSYIREIyamkkiphlnaEELKE 314
Cdd:pfam08565   1 KFAKIPSGDYKASEQFLLKHPEILSEQQKDALLMEAFDAQLEGKTKYARQCVHQSLLLQYCRQL-----------DGRIN 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 374109759  315 VIRVFFQKVfyNTNNKMGKSSFLESVQSKFKHVTERCKVLANEQAD 360
Cdd:pfam08565  70 GVKLFFKRI--TTKDHQAKKLFLDDVQSTYNHIKTRAEEIKQEQAE 113
CDC37_C pfam08564
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 383-463 9.23e-30

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37 pfam03234.


Pssm-ID: 430077  Cd Length: 87  Bit Score: 111.65  E-value: 9.23e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374109759  383 NLPDAQSKDPKEIQKVAAFNKLPKTMQDAVKTQKLDAINEVFAEMSIEEAEAILEIFNEGEIIGVNALL------EGEEE 456
Cdd:pfam08564   1 NLPDAGSEDPEEQKAVEIFESLPPEMQKALKTKSLDEVNKVLGKMPVEEAEEIVELFGEAGILGVEALLvdatteEGEKE 80


                  ....*..
gi 374109759  457 FKELQEH 463
Cdd:pfam08564  81 FKELQEE 87
CDC37_C smart01069
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 383-480 1.64e-26

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37.


Pssm-ID: 215009  Cd Length: 93  Bit Score: 102.86  E-value: 1.64e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374109759   383 NLPDAQSKDPKEIqkvaaFNKLPKTMQDAVKTQKLDAINEVFAEMSIEEAEAILEIFNEGEIIGVNALLEGEEEFKELQE 462
Cdd:smart01069   1 NLPGGLSLDPEEV-----FESLPPELQKAFETKDLDMLNKVLAKMPVEEAEYHLERCIESGLWGVPNAIEDETEFKELQE 75

                           90
                   ....*....|....*...
gi 374109759   463 HYNQEKNMEQLSIGEVDG 480
Cdd:smart01069  76 QYEVEEEAEKEDEEEEDD 93
CR6_interact pfam10147
Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family ...
 9-133 7.92e-03

Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity.


Pssm-ID: 431088 [Multi-domain]  Cd Length: 204  Bit Score: 37.91  E-value: 7.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374109759    9 DKIEISDDSDIEVHPNVDK-RSFIRWKQQSIHEQREKRKQDI-RNLEFQIEMYGHLNKRVDKlMEALSDRELVDRERVTR 86
Cdd:pfam10147  73 EQLEELEAEEREWYPSLAQmLESNRAQKAEKEARRQAREQEIaKKMAKMPQWIADWNAQKAK-REAEAQAAKERKERLVA 151

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 374109759   87 FLNENFdktekgsGENVDPDMPPYNEMVEDLFEQLERNAAEEKKDPK 133
Cdd:pfam10147 152 EAREHF-------GFKVDPRDERFKEMLQQKEKEDKKKVKEAKRKEK 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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