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Conserved domains on  [gi|373947290|gb|AEY68211|]
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putative RNA-binding protein [Clostridium sp. BNL1100]

Protein Classification

protein jag( domain architecture ID 11448923)

SpoIIIJ-associated protein jag is necessary for the third stage of sporulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Jag_EloR NF041568
RNA-binding cell elongation regulator Jag/EloR; Members of this family are nucleic ...
 4-209 5.79e-100

RNA-binding cell elongation regulator Jag/EloR; Members of this family are nucleic acid-binding proteins (RNA or single-stranded DNA) with a KH domain at the N-terminus, an R3H domain at the C-terminus, and additional regions of homology. The founding member of this family was JAG (spoIIIJ Associated Gene) from Bacillus subtilis, but later work in other lineages, such as Streptococcus pneumoniae, as established a role in controlling cell elongation and the operation of the elongasome. The S. pneumoniae protein, a protein that undergoes regulatory phosphorylation and dephosphorylation, is also called RNA-binding cell elongation regulator EloR, and also KhpB.


:

Pssm-ID: 469453 [Multi-domain]  Cd Length: 203  Bit Score: 287.79  E-value: 5.79e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373947290   4 SIEKKGKTVQEAISAALEELQLTQDDVDVEVIEEGNKGIFGIIGSKVARIRVTVKEkeekNRCDIASDFLYTILNNMGV- 82
Cdd:NF041568   1 QVTATGKTVEEAVESALAELGVTRDRVEIEVLEEGSKGFLGLFGSKPAVVKVTLKP----DPIEEAKEFLENVLEAMGId 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373947290  83 EADINVSEDEESIVVDINGDNIGIIIGRRGETMDSLQYLTSLVVNKEYEDYKRVILNVENYRQKREETLIKLANRLADKV 162
Cdd:NF041568  77 EVEIEEEEDDDVIKFNLSGEKLGLLIGKRGQTLDALQYLTNLVANRYSDEYVRVILDAENYRERREETLEQLAERLADKV 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 373947290 163 VKYKKPITLEPMNPYERRIIHSSLQGHKYVETYSTGEEPKRKVVITL 209
Cdd:NF041568 157 KRTKKPVVLEPMPSYERKIIHTALQNHPDVETYSEGEEPNRKVVIAP 203
 
Name Accession Description Interval E-value
Jag_EloR NF041568
RNA-binding cell elongation regulator Jag/EloR; Members of this family are nucleic ...
 4-209 5.79e-100

RNA-binding cell elongation regulator Jag/EloR; Members of this family are nucleic acid-binding proteins (RNA or single-stranded DNA) with a KH domain at the N-terminus, an R3H domain at the C-terminus, and additional regions of homology. The founding member of this family was JAG (spoIIIJ Associated Gene) from Bacillus subtilis, but later work in other lineages, such as Streptococcus pneumoniae, as established a role in controlling cell elongation and the operation of the elongasome. The S. pneumoniae protein, a protein that undergoes regulatory phosphorylation and dephosphorylation, is also called RNA-binding cell elongation regulator EloR, and also KhpB.


Pssm-ID: 469453 [Multi-domain]  Cd Length: 203  Bit Score: 287.79  E-value: 5.79e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373947290   4 SIEKKGKTVQEAISAALEELQLTQDDVDVEVIEEGNKGIFGIIGSKVARIRVTVKEkeekNRCDIASDFLYTILNNMGV- 82
Cdd:NF041568   1 QVTATGKTVEEAVESALAELGVTRDRVEIEVLEEGSKGFLGLFGSKPAVVKVTLKP----DPIEEAKEFLENVLEAMGId 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373947290  83 EADINVSEDEESIVVDINGDNIGIIIGRRGETMDSLQYLTSLVVNKEYEDYKRVILNVENYRQKREETLIKLANRLADKV 162
Cdd:NF041568  77 EVEIEEEEDDDVIKFNLSGEKLGLLIGKRGQTLDALQYLTNLVANRYSDEYVRVILDAENYRERREETLEQLAERLADKV 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 373947290 163 VKYKKPITLEPMNPYERRIIHSSLQGHKYVETYSTGEEPKRKVVITL 209
Cdd:NF041568 157 KRTKKPVVLEPMPSYERKIIHTALQNHPDVETYSEGEEPNRKVVIAP 203
Jag COG1847
Predicted RNA-binding protein Jag (SpoIIIJ-associated), conains KH and R3H domains [General ...
 71-210 3.20e-59

Predicted RNA-binding protein Jag (SpoIIIJ-associated), conains KH and R3H domains [General function prediction only];


Pssm-ID: 441452 [Multi-domain]  Cd Length: 143  Bit Score: 182.62  E-value: 3.20e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373947290  71 DFLYTILNNMGVEADINVSEDEESIVVDINGDNIGIIIGRRGETMDSLQYLTSLVVNKEYEDYKRVILNVENYRQKREET 150
Cdd:COG1847    3 DFLEELLDIMGLDGDIEIEVEGDRLTVDISGEDLGLLIGRRGETLDALQYLTNLAVNRKTGERSRVILDVEGYRERREEE 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 373947290 151 LIKLANRLADKVVKYKKPITLEPMNPYERRIIHSSLQGHKYVETYSTGEEPKRKVVITLK 210
Cdd:COG1847   83 LEELARRAAEKVKRTGKPVELEPMSPYERRIIHDALADDPGVETESEGEEPYRRVVISPK 142
R3H_jag cd02644
R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with ...
 144-210 2.53e-30

R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100073  Cd Length: 67  Bit Score: 106.40  E-value: 2.53e-30
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 373947290 144 RQKREETLIKLANRLADKVVKYKKPITLEPMNPYERRIIHSSLQGHKYVETYSTGEEPKRKVVITLK 210
Cdd:cd02644    1 RERREETLIRLAERAAEKVRRTGKPVKLEPMNAYERRIIHDALANDEDVETESEGEGPYRRVVISPK 67
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
 149-208 3.43e-19

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


Pssm-ID: 460206  Cd Length: 60  Bit Score: 77.53  E-value: 3.43e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 373947290  149 ETLIKLANRLADKVVKYKKPITLEPMNPYERRIIHSSLQGHKyVETYSTGEEPKRKVVIT 208
Cdd:pfam01424   1 EFLEQLAEKLAEFVKDTGKSLELPPMSSYERRIIHELAQKYG-LESESEGEEPNRRVVVY 59
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
131-208 6.34e-19

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 77.34  E-value: 6.34e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 373947290   131 EDYKRVILNVENYRQKREETLIKLANRLADKVVKYKKPITLEPMNPYERRIIHSSLQGHKyVETYSTGEEPKRKVVIT 208
Cdd:smart00393   1 ADFLPVTLDALSYRPRRREELIELELEIARFVKSTKESVELPPMNSYERKIVHELAEKYG-LESESFGEGPKRRVVIS 77
 
Name Accession Description Interval E-value
Jag_EloR NF041568
RNA-binding cell elongation regulator Jag/EloR; Members of this family are nucleic ...
 4-209 5.79e-100

RNA-binding cell elongation regulator Jag/EloR; Members of this family are nucleic acid-binding proteins (RNA or single-stranded DNA) with a KH domain at the N-terminus, an R3H domain at the C-terminus, and additional regions of homology. The founding member of this family was JAG (spoIIIJ Associated Gene) from Bacillus subtilis, but later work in other lineages, such as Streptococcus pneumoniae, as established a role in controlling cell elongation and the operation of the elongasome. The S. pneumoniae protein, a protein that undergoes regulatory phosphorylation and dephosphorylation, is also called RNA-binding cell elongation regulator EloR, and also KhpB.


Pssm-ID: 469453 [Multi-domain]  Cd Length: 203  Bit Score: 287.79  E-value: 5.79e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373947290   4 SIEKKGKTVQEAISAALEELQLTQDDVDVEVIEEGNKGIFGIIGSKVARIRVTVKEkeekNRCDIASDFLYTILNNMGV- 82
Cdd:NF041568   1 QVTATGKTVEEAVESALAELGVTRDRVEIEVLEEGSKGFLGLFGSKPAVVKVTLKP----DPIEEAKEFLENVLEAMGId 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373947290  83 EADINVSEDEESIVVDINGDNIGIIIGRRGETMDSLQYLTSLVVNKEYEDYKRVILNVENYRQKREETLIKLANRLADKV 162
Cdd:NF041568  77 EVEIEEEEDDDVIKFNLSGEKLGLLIGKRGQTLDALQYLTNLVANRYSDEYVRVILDAENYRERREETLEQLAERLADKV 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 373947290 163 VKYKKPITLEPMNPYERRIIHSSLQGHKYVETYSTGEEPKRKVVITL 209
Cdd:NF041568 157 KRTKKPVVLEPMPSYERKIIHTALQNHPDVETYSEGEEPNRKVVIAP 203
Jag COG1847
Predicted RNA-binding protein Jag (SpoIIIJ-associated), conains KH and R3H domains [General ...
 71-210 3.20e-59

Predicted RNA-binding protein Jag (SpoIIIJ-associated), conains KH and R3H domains [General function prediction only];


Pssm-ID: 441452 [Multi-domain]  Cd Length: 143  Bit Score: 182.62  E-value: 3.20e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373947290  71 DFLYTILNNMGVEADINVSEDEESIVVDINGDNIGIIIGRRGETMDSLQYLTSLVVNKEYEDYKRVILNVENYRQKREET 150
Cdd:COG1847    3 DFLEELLDIMGLDGDIEIEVEGDRLTVDISGEDLGLLIGRRGETLDALQYLTNLAVNRKTGERSRVILDVEGYRERREEE 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 373947290 151 LIKLANRLADKVVKYKKPITLEPMNPYERRIIHSSLQGHKYVETYSTGEEPKRKVVITLK 210
Cdd:COG1847   83 LEELARRAAEKVKRTGKPVELEPMSPYERRIIHDALADDPGVETESEGEEPYRRVVISPK 142
R3H_jag cd02644
R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with ...
 144-210 2.53e-30

R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100073  Cd Length: 67  Bit Score: 106.40  E-value: 2.53e-30
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 373947290 144 RQKREETLIKLANRLADKVVKYKKPITLEPMNPYERRIIHSSLQGHKYVETYSTGEEPKRKVVITLK 210
Cdd:cd02644    1 RERREETLIRLAERAAEKVRRTGKPVKLEPMNAYERRIIHDALANDEDVETESEGEGPYRRVVISPK 67
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
 149-208 3.43e-19

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


Pssm-ID: 460206  Cd Length: 60  Bit Score: 77.53  E-value: 3.43e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 373947290  149 ETLIKLANRLADKVVKYKKPITLEPMNPYERRIIHSSLQGHKyVETYSTGEEPKRKVVIT 208
Cdd:pfam01424   1 EFLEQLAEKLAEFVKDTGKSLELPPMSSYERRIIHELAQKYG-LESESEGEEPNRRVVVY 59
Jag_N pfam14804
Jag N-terminus; This domain is found at the N-terminus of proteins containing pfam13083 and ...
 8-57 6.05e-19

Jag N-terminus; This domain is found at the N-terminus of proteins containing pfam13083 and pfam01424, including the jag proteins.


Pssm-ID: 464324  Cd Length: 50  Bit Score: 76.64  E-value: 6.05e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 373947290    8 KGKTVQEAISAALEELQLTQDDVDVEVIEEGNKGIFGIIGSKVARIRVTV 57
Cdd:pfam14804   1 EGKTVEEAIEKALKELGVSRDEVEIEVLEEGSKGFLGLFGKKPAKVRVTV 50
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
131-208 6.34e-19

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 77.34  E-value: 6.34e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 373947290   131 EDYKRVILNVENYRQKREETLIKLANRLADKVVKYKKPITLEPMNPYERRIIHSSLQGHKyVETYSTGEEPKRKVVIT 208
Cdd:smart00393   1 ADFLPVTLDALSYRPRRREELIELELEIARFVKSTKESVELPPMNSYERKIVHELAEKYG-LESESFGEGPKRRVVIS 77
KH-II_Jag cd02414
type II K-homology (KH) RNA-binding domain found in protein Jag and similar proteins; Protein ...
 69-146 1.34e-17

type II K-homology (KH) RNA-binding domain found in protein Jag and similar proteins; Protein Jag, also called SpoIIIJ-associated protein, is associated with SpoIIIJ and is necessary for the third stage of sporulation. Members of this family are mainly from bacteria and contain only one canonical type II K-homology (KH) domain that has the signature motif GXXG (where X represents any amino acid).


Pssm-ID: 411785  Cd Length: 79  Bit Score: 74.10  E-value: 1.34e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 373947290  69 ASDFLYTILNNMGVEADINVSEDEESIVVDINGDNIGIIIGRRGETMDSLQYLTSLVVNKEYEDYKRVILNVENYRQK 146
Cdd:cd02414    2 AKEFLEELLDAMGIEAEVEVEEEEGTVKLNIDGEDPGLLIGKHGETLDALQYLANLVLNKEFGKRVRVVLDVEGYRER 79
R3H cd02325
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most ...
 144-208 5.86e-14

R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich repeats, ring-type zinc fingers, and KH domains. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100064  Cd Length: 59  Bit Score: 63.79  E-value: 5.86e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 373947290 144 RQKREETLIKLANRLAdkvvkyKKPITLEPMNPYERRIIHSSLQGHKyVETYSTGEEPKRKVVIT 208
Cdd:cd02325    1 REEREEELEAFAKDAA------GKSLELPPMNSYERKLIHDLAEYYG-LKSESEGEGPNRRVVIT 58
R3H_NF-X1 cd02643
R3H domain of the X1 box binding protein (NF-X1) and related proteins. Human NF-X1 is a ...
 145-208 3.30e-05

R3H domain of the X1 box binding protein (NF-X1) and related proteins. Human NF-X1 is a transcription factor that regulates the expression of class II major histocompatibility complex (MHC) genes. The Drosophila homolog shuttle craft (STC) has been shown to be a DNA- or RNA-binding protein required for proper axon guidance in the central nervous system and, the yeast homolog FAP1 encodes a dosage suppressor of rapamycin toxicity. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100072  Cd Length: 74  Bit Score: 40.80  E-value: 3.30e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 373947290 145 QKREETLIKLANRLADKVVKYkkpiTLEPMNPYERRIIHSsLQGHKYVETYSTGEEPKRKVVIT 208
Cdd:cd02643   15 EKDLIELVESVNKGKQTSRSH----SFPPMNREKRRIVHE-LAEHFGIESVSYDQEPKRNVVAT 73
KH_4 pfam13083
KH domain;
71-137 2.34e-03

KH domain;


Pssm-ID: 463779  Cd Length: 73  Bit Score: 35.53  E-value: 2.34e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 373947290   71 DFLYTILNNMG-----VEADINVSEDEESIVVDINGDNIGIIIGRRGETMDSLQYLTSLVVNKEYEDYKRVI 137
Cdd:pfam13083   2 ELVEDILKALVddpeeVSVTEEEEEKTVVLELNVAGEDMGKVIGKQGRTLDALRTLVSAAANKDGKRVRVEI 73
R3H_unknown_1 cd02638
R3H domain of a group of eukaryotic proteins with unknown function. The name of the R3H domain ...
 164-207 4.41e-03

R3H domain of a group of eukaryotic proteins with unknown function. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100067  Cd Length: 62  Bit Score: 34.35  E-value: 4.41e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 373947290 164 KYKKPITLEPMNPYERRIIHSSLQGHKYVETYSTGEEPKRKVVI 207
Cdd:cd02638   16 QRYRVLLFPPLNSRRRYLIHQTVENRFLLSTFSVGEGWARRTVV 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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