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Conserved domains on  [gi|347452693|gb|AEO94950|]
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sphingosine-1-phosphate receptor 1, partial [Petromus typicus]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11607441)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
2-278 8.53e-168

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


:

Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 467.05  E-value: 8.53e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   2 KLTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMF 81
Cdd:cd15346    1 KLTSVVFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPTQWFLREGSMF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  82 VALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILF 161
Cdd:cd15346   81 VALSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 162 CTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVK 241
Cdd:cd15346  161 CTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNIRKASRSSEKSMALLKTVIIVLSVFIACWAPLFILLLLDVGCKVK 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 347452693 242 TCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15346  241 TCSILFKAEYFLVLAVLNSATNPIIYTLTNKEMRRAF 277
 
Name Accession Description Interval E-value
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
2-278 8.53e-168

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 467.05  E-value: 8.53e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   2 KLTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMF 81
Cdd:cd15346    1 KLTSVVFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPTQWFLREGSMF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  82 VALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILF 161
Cdd:cd15346   81 VALSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 162 CTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVK 241
Cdd:cd15346  161 CTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNIRKASRSSEKSMALLKTVIIVLSVFIACWAPLFILLLLDVGCKVK 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 347452693 242 TCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15346  241 TCSILFKAEYFLVLAVLNSATNPIIYTLTNKEMRRAF 277
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
18-267 7.62e-38

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 135.12  E-value: 7.62e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   18 ENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVayianLLLSGATTYKLTPAQWFLREG-------SMFVALSASVFS 90
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSL-----LTLPFWLVYYLNHGDWPFGSAlckivgaLFVVNGYASILL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   91 LLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLP-IMGWNCI---GSLPSCSTVLPLYHK----HYILF 161
Cdd:pfam00001  76 LTAISIDRYLAIVHpLRYKRRRTPRRAKVLILVIWVLALLLSLPPlLFGWTLTvpeGNVTVCFIDFPEDLSkpvsYTLLI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  162 CTTVFTLLLLTIVILYCRIYSLVRTRSRRLtfrknisKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKV- 240
Cdd:pfam00001 156 SVLGFLLPLLVILVCYTLIIRTLRKSASKQ-------KSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDc 228
                         250       260
                  ....*....|....*....|....*...
gi 347452693  241 -KTCQILYKAEYFLVLAVLNSGTNPIIY 267
Cdd:pfam00001 229 eLSRLLDKALSVTLWLAYVNSCLNPIIY 256
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
6-278 4.94e-04

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 41.43  E-value: 4.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLlTIWKTKKFHRPMYYFIGNLALSDLLAgVAYIANLLLSGATTYKLTPAQWFLREGSMFVALS 85
Cdd:PHA02834  33 VFYILLFIFGLIGNVLVI-AVLIVKRFMFVVDVYLFNIAMSDLML-VFSFPFIIHNDLNEWIFGEFMCKLVLGVYFVGFF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  86 ASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYIL----- 160
Cdd:PHA02834 111 SNMFFVTLISIDRYILVVNATKIKNKSISLSVLLSVAAWVCSVILSMPAMVLYYVDNTDNLKQCIFNDYHENFSWsaffn 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 161 FCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKniskasrsseKSLALLKTVIIVLSVFiacWAPLFILL-------- 232
Cdd:PHA02834 191 FEINIFGIVIPLIILIYCYSKILYTLKNCKNKNKT----------RSIKIILTVVTFTVVF---WVPFNIVLfinslqsv 257
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 347452693 233 -LLDVGCkVKTCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:PHA02834 258 gLIDIGC-YHFKKIVYSIDIAELISFVHCCVNPIIYAFVGKNFKKVF 303
 
Name Accession Description Interval E-value
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
2-278 8.53e-168

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 467.05  E-value: 8.53e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   2 KLTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMF 81
Cdd:cd15346    1 KLTSVVFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPTQWFLREGSMF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  82 VALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILF 161
Cdd:cd15346   81 VALSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 162 CTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVK 241
Cdd:cd15346  161 CTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNIRKASRSSEKSMALLKTVIIVLSVFIACWAPLFILLLLDVGCKVK 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 347452693 242 TCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15346  241 TCSILFKAEYFLVLAVLNSATNPIIYTLTNKEMRRAF 277
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
2-278 5.25e-140

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 396.46  E-value: 5.25e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   2 KLTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMF 81
Cdd:cd15102    1 GATSVVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANILLSGARTLRLSPAQWFLREGSMF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  82 VALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILF 161
Cdd:cd15102   81 VALSASVFSLLAIAIERHLTMAKMKPYGASKTSRVLLLIGACWLISLLLGGLPILGWNCLGALDACSTVLPLYSKHYVLF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 162 CTTVFTLLLLTIVILYCRIYSLVRTRSRRLTfrkniskASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVK 241
Cdd:cd15102  161 CVTIFAGILAAIVALYARIYCLVRASGRKAT-------RASASPRSLALLKTVLIVLLVFIACWGPLFILLLLDVACPVK 233
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 347452693 242 TCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15102  234 TCPILYKADWFLALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
3-278 6.59e-115

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 332.94  E-value: 6.59e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMFV 82
Cdd:cd15345    2 LTTIFFLVICSFIVLENLMVLIAIWKNNRFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTQWFLREGSMFV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 ALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILFC 162
Cdd:cd15345   82 ALGASTFSLLAIAIERHLTMIKMRPYDANKRYRVFLLIGTCWLISVLLGALPILGWNCLDNLPDCSTILPLYSKKYVAFC 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 163 TTVFTLLLLTIVILYCRIYSLVRTRSRRLTfrkniskASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKT 242
Cdd:cd15345  162 ISIFIAILVAIVILYARIYILVKSSSRRVT-------NHRNSERSMALLRTVVIVVGVFIACWSPLFILLLIDVACEVKQ 234
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 347452693 243 CQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15345  235 CPILYKADWFIALAVLNSAMNPIIYTLASKEMRRAF 270
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
2-277 7.88e-110

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 320.23  E-value: 7.88e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   2 KLTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMF 81
Cdd:cd15348    1 KADAVAFLAVCAFIVLENLIVLLALWRNKKFHSPMFYLLGSLTLSDLLAGAAYAANILMSGANTLKLTPALWFLREGGVF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  82 VALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILF 161
Cdd:cd15348   81 ITLTASVFSLLAIAIERHITMVRMKPYPGDKRGRMFLLIGAAWLVSILLGVLPILGWNCLGNLDACSTVLPLYAKSYILF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 162 CTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVK 241
Cdd:cd15348  161 CITVFLAILAAIVVLYARIYRIVKANSQRLGALPTRKGRARRSQKYLALLKTVTIVLGTFVACWLPLFLLLLLDVSCPAQ 240
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 347452693 242 TCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRA 277
Cdd:cd15348  241 ACPVLLKADYFLGLAMINSLLNPIIYTLTSRDMRRA 276
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
5-278 3.16e-101

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 297.88  E-value: 3.16e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMFVAL 84
Cdd:cd15347    4 SIFIVILCCIIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGVAFIANILLSGSVTFRLTPVQWFIREGTAFITL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  85 SASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILFCTT 164
Cdd:cd15347   84 SASVFSLLAIAIERHVAITKVKLYGSDKNCRMVLLIGACWVISIVLGGLPILGWNCIGNLEDCSTVLPLYSKHYILFVVT 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 165 VFTLLLLTIVILYCRIYSLVRTrsrrltfrkniSKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCQ 244
Cdd:cd15347  164 IFSIILLSIVILYVRIYCIVRS-----------SHAEMAAPQTLALLKTVTIVLGVFIVCWLPAFIILLLDTSCKVKSCP 232
                        250       260       270
                 ....*....|....*....|....*....|....
gi 347452693 245 ILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15347  233 ILYKADYFFSVATLNSALNPVIYTLRSKDMRKEF 266
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
6-278 2.91e-88

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 265.31  E-value: 2.91e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMFVALS 85
Cdd:cd14972    3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  86 ASVFSLLAIAIERYITMLKMKLH-NGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSL-PSCSTVLPLYHKHYILFCT 163
Cdd:cd14972   83 ASAYSLLAIAVDRYISIVHGLTYvNNVTNKRVKVLIALVWVWSVLLALLPVLGWNCVLCDqESCSPLGPGLPKSYLVLIL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 164 TVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEkSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKvKTC 243
Cdd:cd14972  163 VFFFIALVIIVFLYVRIFWCLWRHANAIAARQEAAVPAQPST-SRKLAKTVVIVLGVFLVCWLPLLILLVLDVLCP-SVC 240
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 347452693 244 QILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd14972  241 DIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
3-277 4.68e-83

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 252.01  E-value: 4.68e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMFV 82
Cdd:cd15349    2 ALTVLFICISVLIILENLLVLLAILRRVRLRRWVYICLANIALSDLLTGTSYLVNICLSGERTFRLTPALWFLREGLLFT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 ALSASVFSLLAIAIERYITMLKMKLHNGS-NSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILF 161
Cdd:cd15349   82 ALAASTFSLLVTAVERYATMVRPVAENTAtKTYRVYGMIVLCWILAFLIGFLPLLGWNCLCDFRSCSSLLPLYSKSYILF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 162 CTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRkniskasRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVK 241
Cdd:cd15349  162 CLVIFFIILLTIIGLYFAIYCLVRASGQRVISA-------RSRRRSLRLLKTVLMILGAFMVCWGPLFILLLVDFFCSSR 234
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 347452693 242 TCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRA 277
Cdd:cd15349  235 SCKPLFGMEWVLALAVLNSAINPLIYSFRSLEVRRA 270
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
9-278 3.29e-69

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 216.59  E-value: 3.29e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   9 ILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMFVALSASV 88
Cdd:cd15342    8 LTVSVIVLLTNLLVIAAIFINRRFHYPIYYLLGNLAAADLFAGVAYLFLMFHTGPWTAKLSLYQWFLRQGLLDTSLTASV 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  89 FSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILFCTTVFTL 168
Cdd:cd15342   88 ANLLAIAVERHQTIFTMQLHSKMSNQRVVILIFGIWMVALILGLIPAMGWNCLCDLKRCSTMAPLYSRSYLVFWALSNLL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 169 LLLTIVILYCRIYSLVRTRSRRLTfrKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDvGCKVKTCQILYK 248
Cdd:cd15342  168 TFLIMVAVYTRIFIYVRRKSQRMS--EHHSSHPRYRETVLGLMKTVVIILGAFVVCWTPGQVVLLLD-GLGCESCNVLAY 244
                        250       260       270
                 ....*....|....*....|....*....|
gi 347452693 249 AEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15342  245 EKYFLLLAEINSLVNPIVYSYRDKEMRKTF 274
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
2-278 8.81e-65

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 205.44  E-value: 8.81e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   2 KLTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMF 81
Cdd:cd15101    1 VLVMGLGITVCIFIMLANLLVIAAIYKNRRFHFPIYYLLANLAAADFFAGLAYFFLMFNTGPNTRRLTVSTWFLRQGLLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  82 VALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILF 161
Cdd:cd15101   81 TSLTASVANLLAIAVERHISVMRMQLHSRLSNRRVVVLIVLVWTMAIVMGAIPSVGWNCLCAIDACSNMAPLYSRSYLVF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 162 CTTVFTLLLLTIVILYCRIYSLVRTRSRRLTfrKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDvGCKVK 241
Cdd:cd15101  161 WAISNLVTFLVMVVVYARIFVYVRRRTNRMS--PHTSGSIRNRDTMMSLLKTVVIVLGAFVVCWTPGLVVLLLD-GLCCR 237
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 347452693 242 TCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15101  238 QCNVLAVEKFFLLLAEFNSAVNPIIYSYRDKEMSGTF 274
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
2-278 9.88e-59

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 189.85  E-value: 9.88e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   2 KLTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMF 81
Cdd:cd15344    1 KLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLID 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  82 VALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILF 161
Cdd:cd15344   81 TSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 162 CTTVFTLLLLTIVILYCRIYSLVRTRSRRLTfrKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCkvK 241
Cdd:cd15344  161 WAIFNLVTFVVMVVLYAHIFGYVRQRTMRMS--RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCC--P 236
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 347452693 242 TCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15344  237 QCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 273
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
12-278 1.30e-55

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 181.61  E-value: 1.30e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  12 CCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSL 91
Cdd:cd15343   11 CLFIFVSNSLVIAAVVKNKRFHYPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDTSLSASLTNL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  92 LAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILFCTTVFTLLLL 171
Cdd:cd15343   91 LVIAVERHISIMRMKVHSNLTKRRVTLLIALVWAIAIFMGAVPTLGWNCICNISACSSLAPIYSRSYLVFWSVSNLVVFL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 172 TIVILYCRIYSLVRTRSRRLTFRKNISKASRSSekSLALLKTVIIVLSVFIACWAPLFILLLLDvGCKVKTCQILYKAEY 251
Cdd:cd15343  171 IMVVVYLRIYVYVQRKTNVLSPHTSGSINRRRT--PIKLMKTVMTVLGAFVICWTPGLVVLLLD-GLNCTRCGVQHVKRW 247
                        250       260
                 ....*....|....*....|....*..
gi 347452693 252 FLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15343  248 FLLLALLNSVMNPIIYSYKDEEMWGTM 274
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
5-271 8.23e-39

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 138.19  E-value: 8.23e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYI-ANLLLSGATTYKLTPAQWFLREGSMFVA 83
Cdd:cd00637    2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIpFSLVSLLLGRWWFGDALCKLLGFLQSVS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  84 LSASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKH----- 157
Cdd:cd00637   82 LLASILTLTAISVDRYLAIVHpLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTlskay 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 158 YILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVG 237
Cdd:cd00637  162 TIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVF 241
                        250       260       270
                 ....*....|....*....|....*....|....
gi 347452693 238 CKVKTCQILYKAEYFLVLAVLNSGTNPIIYTLTN 271
Cdd:cd00637  242 GPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
18-267 7.62e-38

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 135.12  E-value: 7.62e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   18 ENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVayianLLLSGATTYKLTPAQWFLREG-------SMFVALSASVFS 90
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSL-----LTLPFWLVYYLNHGDWPFGSAlckivgaLFVVNGYASILL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   91 LLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLP-IMGWNCI---GSLPSCSTVLPLYHK----HYILF 161
Cdd:pfam00001  76 LTAISIDRYLAIVHpLRYKRRRTPRRAKVLILVIWVLALLLSLPPlLFGWTLTvpeGNVTVCFIDFPEDLSkpvsYTLLI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  162 CTTVFTLLLLTIVILYCRIYSLVRTRSRRLtfrknisKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKV- 240
Cdd:pfam00001 156 SVLGFLLPLLVILVCYTLIIRTLRKSASKQ-------KSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDc 228
                         250       260
                  ....*....|....*....|....*...
gi 347452693  241 -KTCQILYKAEYFLVLAVLNSGTNPIIY 267
Cdd:pfam00001 229 eLSRLLDKALSVTLWLAYVNSCLNPIIY 256
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
3-278 7.16e-36

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 129.99  E-value: 7.16e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVayianLLLSGATTYKLTPAQWFLREGSMFV 82
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVAL-----LVMPFSAVYTLLGYWPFGPVLCRFW 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 AL------SASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTV-LPLY 154
Cdd:cd14967   76 IAldvlccTASILNLCAISLDRYLAITRpLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCEcEFTP 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 155 HKHYILFCTTVFTLL-LLTIVILYCRIYSLVRTRSRrltfrkniskasrssekslaLLKTVIIVLSVFIACWAPLFILLL 233
Cdd:cd14967  156 NKIYVLVSSVISFFIpLLIMIVLYARIFRVARRELK--------------------AAKTLAIIVGAFLLCWLPFFIIYL 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 347452693 234 LDVGCKVKTC-QILYKaeYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd14967  216 VSAFCPPDCVpPILYA--VFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
10-277 2.06e-28

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 110.64  E-value: 2.06e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  10 LICCciilENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLL---LSGATTYKLTPAqwflreGSMFVALSA 86
Cdd:cd15100   13 LIAC----ENAIVVAIIFSTPSLRAPMFLLIGSLALADLLAGLGLILHFVfryCVYSEALSLVSV------GLLVAAFSA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  87 SVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILFCtTV 165
Cdd:cd15100   83 SVCSLLAITVDRYLSLYNaLTYYSERTLTFTYVMLALLWTLALGLGLLPVLGWNCLREGSSCSVVRPLTKNHLAVLA-VA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 166 FTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASR--SSEKSLAllkTVIIVLSVFIACWAPLFILLLLDVGckvkTC 243
Cdd:cd15100  162 FLLVFALMLQLYAQICRIVLRHAHQIALQRHFLAPSHyvATRKGVS---TLALILGTFAACWIPFAVYCLLGDG----SS 234
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 347452693 244 QILYKaeYFLVL-AVLNSGTNPIIYTLTNKEMRRA 277
Cdd:cd15100  235 PALYT--YATLLpATYNSMINPIIYAFRNQDIQKV 267
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
16-278 3.79e-28

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 110.38  E-value: 3.79e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFH-RPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAI 94
Cdd:cd15340   15 VLENLLVLCVILHSRSLRcRPSYHFIGSLAVADLLGSVIFVYSFLDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLT 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  95 AIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILFCTTVFTLLLLTI 173
Cdd:cd15340   95 AIDRYISIHRpLAYKRIVTRTKAVIAFCVMWTIAIVIAVLPLLGWNCKKLNSVCSDIFPLIDETYLMFWIGVTSVLLLFI 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 174 VILYCRIYSLVRTRSRRLTFR---KNISKASRSSEK-----------SLALLKTVIIVLSVFIACWAPLFILLLLDVGCK 239
Cdd:cd15340  175 VYAYMYILWKAHHHAVRMLQRgtqKSIIVYTSEDGKvqttrpdqtrmDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGK 254
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 347452693 240 V-KTCQILYKaeYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15340  255 MnKLIKTVFA--FCSMLCLLNSTVNPIIYALRSKDLRHAF 292
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
15-278 2.43e-27

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 107.81  E-value: 2.43e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  15 IILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSgattYKL-TPAQWFLREGSMFVALSASVFSLLA 93
Cdd:cd15961   14 ISCENAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIGLILNFIFA----YLLqSEAAKLVTVGLIVASFSASVCSLLA 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  94 IAIERYITM-LKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYhKHYILFCTTVFTLLLLT 172
Cdd:cd15961   90 ITVDRYLSLyYALTYNSERTVTFTYVMLVLLWGASICLGLLPVMGWNCLADESTCSVVRPLT-KNNAAILSVSFLLMFAL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 173 IVILYCRIYSLVRTRSRRLTFRKNISKASR--SSEKSLAllkTVIIVLSVFIACWAPLFILLLLdvgckvktCQILYKAE 250
Cdd:cd15961  169 MLQLYIQICKIVMRHAHQIALQHHFLATSHyvTTRKGVS---TLAIILGTFAACWMPFTLYSLI--------ADYTYPSI 237
                        250       260       270
                 ....*....|....*....|....*....|.
gi 347452693 251 Y---FLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15961  238 YtyaTLLPATYNSIINPVIYAFRNQEIQKAL 268
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
5-278 3.29e-27

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 107.73  E-value: 3.29e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYI--ANLLLSGATTYkltpaqwflREGSMFV 82
Cdd:cd14968    4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIplAILISLGLPTN---------FHGCLFM 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 AL------SASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGWN--------CIGSLPSC 147
Cdd:cd14968   75 AClvlvltQSSIFSLLAIAIDRYLAIKIpLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFGWNngaplesgCGEGGIQC 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 148 --STVLPLYHKHYILFcTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACW 225
Cdd:cd14968  155 lfEEVIPMDYMVYFNF-FACVLVPLLIMLVIYLRIFRVIRKQLRQIESLLRSRRSRSTLQKEVKAAKSLAIILFLFALCW 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 347452693 226 APLFILLLLDVGCkvKTCQILYKAEYF-LVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd14968  234 LPLHIINCITLFC--PECKVPKILTYIaILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
16-278 2.02e-25

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 102.61  E-value: 2.02e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFH-RPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAI 94
Cdd:cd15099   15 FLENILVLLTILSSTALRrRPSYLFIGSLALADMLASVIFTISFLDFHVFHQRDSRNLFLFKLGGVTMAFTASVGSLLLT 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  95 AIERYITMLKMKLHNG-SNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILFCTTVFTLLLLTI 173
Cdd:cd15099   95 ALDRYLCIYQPSNYKLlVTRTRAKVAILLMWCVTIIISFLPLMGWRCKTWDSPCSRLFPYIDRHYLASWTGLQLVLLFLI 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 174 VILYCRI----YSLVRTRSRRLTFRKNISKASRsSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCQILYKA 249
Cdd:cd15099  175 IYAYPYIlwkaHRHEANMGGPKLGRQQVKGQAR-MRMDIRLAKTLSLILLVLAICWLPVLAFMLVDVRVTLTNKQKRMFA 253
                        250       260
                 ....*....|....*....|....*....
gi 347452693 250 eYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15099  254 -FCSMLCLVNSCVNPIIYALRSRELRGAM 281
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
1-278 6.34e-25

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 100.88  E-value: 6.34e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   1 IKLTTVVFILIcccIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVayianLLLSGATTYKLTpAQWFLREG-- 78
Cdd:cd15059    3 ISSIVSVVILL---IIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGL-----LIMPFSLVNELM-GYWYFGSVwc 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  79 SMFVAL-----SASVFSLLAIAIERYITMLKMKLHNGSNSS-RSFLLISACWVISLILGGLPIMGW----NCIGSLPSC- 147
Cdd:cd15059   74 EIWLALdvlfcTASIVNLCAISLDRYWSVTQAVEYNLKRTPrRAKAMIAAVWIISAVISLPPLFGWkdeqPWHGAEPQCe 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 148 -STVLPlyhkhYILF-CTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFrkniskasrssekslallktVI-IVLSVFIAC 224
Cdd:cd15059  154 lSDDPG-----YVLFsSIGSFYIPLLIMIIVYARIYRAAKRKERRFTL--------------------VLgVVMGAFVLC 208
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 347452693 225 WAPLFILLLLDVGCKvkTCQI---LYKaeYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15059  209 WLPFFFTYPLVVVCK--TCGVpelLFK--FFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
9-277 2.11e-24

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 99.62  E-value: 2.11e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   9 ILIC---CCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPaqwFLREGSMFVALS 85
Cdd:cd15962    5 IMLCisgTVIACENAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCGLILNFVFQYVIQSETIS---LITVGFLVASFT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  86 ASVFSLLAIAIERYITMLKMKLHNGSNSSRSF-LLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILFcTT 164
Cdd:cd15962   82 ASVSSLLAITVDRYLSLYNALTYYSEKTVLGVhLMLAATWGVSLCLGLLPVLGWNCLEERASCSIVRPLTKSNVTLL-SA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 165 VFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASR--SSEKSLAllkTVIIVLSVFIACWAPLFILLLldVGCKVKT 242
Cdd:cd15962  161 SFFFIFILMLHLYIKICKIVCRHAHQIALQQHFLTASHyvATKKGVS---TLAIILGTFGASWLPFAIYCV--VGDHEYP 235
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 347452693 243 CQILYKAeyfLVLAVLNSGTNPIIYTLTNKEMRRA 277
Cdd:cd15962  236 AVYTYAT---LLPATYNSMINPIIYAYRNQEIQRS 267
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
16-277 5.25e-24

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 98.76  E-value: 5.25e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFHR-PMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAI 94
Cdd:cd15341   15 ILENVAVLYLILSSPKLRRkPSYLFIGSLALADFLASVVFACSFVDFHVFHGVDSSAIFLLKLGGVTMSFTASLGSLLLM 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  95 AIERYITMLKMKLHNGS-NSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILFCTTVFTLLLLTI 173
Cdd:cd15341   95 AFDRYVCIYYPSEYKALvTRKRALVALAVMWVLTALIAYLPLMGWNCCPLNSPCSELFPLIPNDYLLSWLLLVAILLSGI 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 174 VILYCRIysLVRTRSRRLTFRKNISKASRSSEK---SLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVkTCQILYKAE 250
Cdd:cd15341  175 IYTYGHV--LWKAHKHVVYMEKHQDQQGPGNARmrlDVRLAKTLGLVLAVLLICWSPVLALMMHSLFTSL-SDHIKKAFA 251
                        250       260
                 ....*....|....*....|....*..
gi 347452693 251 YFLVLAVLNSGTNPIIYTLTNKEMRRA 277
Cdd:cd15341  252 FCSTLCLVNSMVNPIIYALRSRELRSS 278
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
6-276 1.15e-23

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 97.65  E-value: 1.15e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAyianLLLSGATTYKLTPAQWFLRE-GSMFVAL 84
Cdd:cd15963    5 VVLCISGTVISCENAIVVAVIFYTPAFRAPMFLLIGSLATADLLAGLG----LILHFAFVYCIQSAPVNLVTvGLLAPSF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  85 SASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILFcT 163
Cdd:cd15963   81 TASVSSLLAITIDRYLSLYNaLTYYSERTVTRTYIMLILTWGASLCLGLLPVVGWNCLKDPSTCSVVKPLTKNHLVIL-S 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 164 TVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASR--SSEKSLAllkTVIIVLSVFIACWAPLFILLLLDvgckvk 241
Cdd:cd15963  160 ISFFMVFALMLQLYAQICRIVCRHAHQIALQRHFLPTSHyvTTRKGIA---TLAVILGTFASCWLPFAVYCLLG------ 230
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 347452693 242 tcQILYKAEY---FLVLAVLNSGTNPIIYTLTNKEMRR 276
Cdd:cd15963  231 --DYTYPALYtyaTLLPATYNSMINPIIYAFRNQEIQK 266
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
7-278 1.67e-23

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 97.17  E-value: 1.67e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYI-ANLLLSGATTYKLTPAQWFLRE-----GSM 80
Cdd:cd15103    6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNAlETIVIILLNNGYLVPRDSFEQHidnviDSM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 FV-ALSASVFSLLAIAIERYITML-KMKLHNGSNSSRSFLLISACWVISLIlgglpimgwncigslpsCSTVLPLYHKH- 157
Cdd:cd15103   86 ICsSLLASICSLLAIAVDRYITIFyALRYHSIMTVRRAGVIITAIWVFCTV-----------------CGILFIIYSDSv 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 158 YILFCTTVF-TLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALlkTVIIVLSVFIACWAPLFILLLLDV 236
Cdd:cd15103  149 PVIICLISMfFAMLVLMASLYVHMFLLARSHVKKIAALPGQRSTRQRANMKGAV--TLTILLGVFIFCWAPFFLHLTLMI 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 347452693 237 GCKVKTCQILYKAEY--FLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15103  227 SCPSNPYCACYMSHFnvYLILIMCNSVIDPLIYAFRSQELRKTF 270
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
3-278 1.75e-22

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 94.32  E-value: 1.75e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVayianLLLSGATTYKLTpAQWFLreGSMFV 82
Cdd:cd15064    2 LISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAV-----LVMPLSAVYELT-GRWIL--GQVLC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 AL---------SASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGW---------NCIGS 143
Cdd:cd15064   74 DIwisldvtccTASILHLCVIALDRYWAITDaVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWrtpdsedpsECLIS 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 144 LPSCSTVLPLYHKHYILFCttvftllllTIVILYCRIYSlVRTRSRRLTfrkniskasrssekslallKTVIIVLSVFIA 223
Cdd:cd15064  154 QDIGYTIFSTFGAFYIPLL---------LMLILYWKIYR-AAARERKAA-------------------KTLGIILGAFIV 204
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 347452693 224 CWAPLFILLLLDVGCkvKTCQI-LYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15064  205 CWLPFFLVALIVPLC--SHCWIpLALKSFFLWLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
7-278 4.06e-22

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 93.46  E-value: 4.06e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYI-ANLLLSGATTYKLTPAQWFLR------EGS 79
Cdd:cd15354    6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAwETITIYLLNNRHLVIEDAFVRhidnvfDSL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  80 MFVALSASVFSLLAIAIERYITML-KMKLHNGSNSSRSFLLISACWVISlilgglpimgwncigslPSCSTVLPLYHKH- 157
Cdd:cd15354   86 ICISVVASMCSLLAIAVDRYVTIFyALRYHNIMTVRRAGIIIACIWTFC-----------------TGCGIIFILYSESt 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 158 YILFCTTVF-TLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALlkTVIIVLSVFIACWAPLFILLLLDV 236
Cdd:cd15354  149 YVIICLITMfFAMLFLMVSLYIHMFLLARTHVKRIAALPGYNSVRQRTSMKGAV--TLTILLGIFIVCWAPFFLHLILMI 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 347452693 237 GCKVKTCQILYKAEY--FLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15354  227 SCPQNLYCVCFMSHFnmYLILIMCNSVIDPLIYAFRSQEMRKTF 270
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
15-278 8.34e-22

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 92.65  E-value: 8.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  15 IILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLlsgATTYKLTPAQWFLREGSMFVALSASVFSLLAI 94
Cdd:cd15960   14 MACENAIVIAILFYTPSLRAPMFILIGSLALADLLAGLGLIANFV---AIYVMNSEAVTLCSAGLLLAAFSASVCSLLAI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  95 AIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYhKHYILFCTTVFTLLLLTI 173
Cdd:cd15960   91 TVDRYLSLYNaLTYHTERTLTFTYGLLALLWLTCIGIGLLPAMGWNCLRAPASCSVLRPVT-KNNAAVLAVSFLLLFALM 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 174 VILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLAlLKTVIIVLSVFIACWAPLFILLLLdvgcKVKTCQILYKaeYFL 253
Cdd:cd15960  170 MQLYLQICRIAFRHAQQIAVQHQFVNFCLASSTRKG-VSTLSLILATFAFCWVPFAVYSMV----ADSSYPMIYT--YYL 242
                        250       260
                 ....*....|....*....|....*.
gi 347452693 254 VL-AVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15960  243 VLpAACNSVINPIIYAFRNPDIQKSL 268
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
5-278 1.10e-21

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 92.02  E-value: 1.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayIANLLLSGATTYKLTPAQWFLRE--GSMFV 82
Cdd:cd15053    4 ALFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLL-----VAILVMPFAVYVEVNGGKWYLGPilCDIYI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 AL-----SASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGgLPIM-GWNCIGslPSCSTVLPLYH 155
Cdd:cd15053   79 AMdvmcsTASIFNLCAISIDRYIAVTQpIKYARQKNSKRVLLTIAIVWVVSAAIA-CPLLfGLNNVP--YRDPEECRFYN 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 156 KHYILFCTTVFTLL-LLTIVILYCRIYSLVRtRSRRLTfrkniskasrssekslallKTVIIVLSVFIACWAPLFILLLL 234
Cdd:cd15053  156 PDFIIYSSISSFYIpCIVMLLLYYRIFRALR-REKKAT-------------------KTLAIVLGVFLFCWLPFFTLNIL 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 347452693 235 DVGCKV---KTCQILYKAeYFLV--LAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15053  216 NAICPKlqnQSCHVGPAL-FSLTtwLGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
4-278 1.70e-21

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 92.17  E-value: 1.70e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   4 TTVVFILICCCI--ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVayianlLLSGATTYKLTPAQWFLRE---- 77
Cdd:cd15056    1 VVLSTFLSLVILltILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAV------LVMPFGAIELVNNRWIYGEtfcl 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  78 --GSMFVAL-SASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIM-GWNCIG-------SLPS 146
Cdd:cd15056   75 vrTSLDVLLtTASIMHLCCIALDRYYAICCQPLVYKMTPLRVAVMLGGCWVIPTFISFLPIMqGWNHIGiedliafNCAS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 147 CSTVLP-LYHKHYILFCTTVFTLL-LLTIVILYCRIYSLVRTRSRRL-TFRKNISKASRSSEKSLALL-------KTVII 216
Cdd:cd15056  155 GSTSCVfMVNKPFAIICSTVAFYIpALLMVLAYYRIYVAAREQAHQIrSLQRAGSSNHEADQHRNSRMrtetkaaKTLGI 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 347452693 217 VLSVFIACWAPLFILLLLDVGCKVKTCQILYKAeyFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15056  235 IMGCFCVCWAPFFVTNIVDPFIGYRVPYLLWTA--FLWLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
3-278 2.89e-21

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 91.12  E-value: 2.89e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLR------ 76
Cdd:cd15353    2 VSPEVFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNGNDTDAQSFTVnidnvi 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  77 EGSMFVALSASVFSLLAIAIERYITML-KMKLHNGSNSSRSFLLISACWVISLILGGLPIMgwncigslpscstvlpLYH 155
Cdd:cd15353   82 DSVICSSLLASICSLLSIAVDRYFTIFyALQYHNIMTVRRAGVIITCIWTACTVSGVLFII----------------YSD 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 156 KHYILFCTTVFT-LLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALlkTVIIVLSVFIACWAPLFILLLL 234
Cdd:cd15353  146 SSVVIICLISMFfTMLALMASLYVHMFLLARLHIKRIAVLPGTGPIRQGANMKGAI--TLTILLGVFVVCWAPFFLHLIF 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 347452693 235 DVGCKVKTCQILYKAEY--FLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15353  224 YISCPRNPYCVCFMSHFnmYLILIMCNSVIDPLIYAFRSQELRKTF 269
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
3-278 6.19e-21

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 90.47  E-value: 6.19e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVayianLLLSGATTYKLTPaQWFLreG---- 78
Cdd:cd15051    2 VLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGL-----LVLPFSAIYELRG-EWPL--Gpvfc 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  79 ----SMFVAL-SASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPI-MGWNCIGslpscSTVL 151
Cdd:cd15051   74 niyiSLDVMLcTASILNLFAISLDRYLAITApLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIhLGWNTPD-----GRVQ 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 152 PLYHKHYILFCTTVFTLLLLTIV----------ILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLA----LLKTVIIV 217
Cdd:cd15051  149 NGDTPNQCRFELNPPYVLLVAIGtfylpllimcGVYLRIFRIAREQAKRINALTPASTANSSKSAATArehkATVTLAAV 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 347452693 218 LSVFIACWAPLFILLLLDVGCKVKTCQILYKAeyFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15051  229 LGAFIICWFPYFTYFTYRGLCGDNINETALSV--VLWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
5-278 1.30e-20

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 89.57  E-value: 1.30e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYkltpaqWFLRE------- 77
Cdd:cd14969    4 AVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGR------WSFGDpgcviyg 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  78 -GSMFVALsASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHK 156
Cdd:cd14969   78 fAVTFLGL-VSISTLAALAFERYLVIVRPLKAFRLSKRRALILIAFIWLYGLFWALPPLFGWSSYVPEGGGTSCSVDWYS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 157 H------YILFCTTVFTLL-LLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLF 229
Cdd:cd14969  157 KdpnslsYIVSLFVFCFFLpLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTKKAEKKVAKMVLVMIVAFLIAWTPYA 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 347452693 230 ILLLLDVGCKVKTCQILYkAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd14969  237 VVSLYVSFGGESTIPPLL-ATIPALFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
15-278 3.29e-20

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 88.58  E-value: 3.29e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  15 IILENIFVLLTIWKTKKFHR-PMYYFIGNLALSDLLAGVA---YIANLLLSGATtykltPAQWFLREGSM-FVALS--AS 87
Cdd:cd15104   13 IITGNLLVIVALLKLIRKKDtKSNCFLLNLAIADFLVGLAipgLATDELLSDGE-----NTQKVLCLLRMcFVITScaAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  88 VFSLLAIAIERYITmLKMKLH--NGSNSSRSFLLISACWVISLILGGLPIM--GWNCIGSLPSCSTVLPLYHKHYILFCT 163
Cdd:cd15104   88 VLSLAAIAFDRYLA-LKQPLRykQIMTGKSAGALIAGLWLYSGLIGFLPLIspQFQQTSYKGKCSFFAAFHPRVLLVLSC 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 164 TVFTLLLLTIVILYCRIYSLVRTRSRRL-TFRKNISKASRSSE--KSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKv 240
Cdd:cd15104  167 MVFFPALLLFVFCYCDILKIARVHSRAIyKVEHALARQIHPRRtlSDFKAARTVAVLIGCFLLSWLPFQITGLVQALCD- 245
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 347452693 241 kTCQILYKAEYFL-VLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15104  246 -ECKLYDVLEDYLwLLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
6-278 8.97e-20

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 87.29  E-value: 8.97e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILiccCIIlENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGV-----AYIANLLLS---GATTYKLTPAqwflre 77
Cdd:cd15207    9 LIFLL---CVV-GNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVfcmpfTLVDNILTGwpfGDVMCKLSPL------ 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  78 gSMFVALSASVFSLLAIAIERYITML---KMKLhngsNSSRSFLLISACWVISLI--------LGGLPIMGWNcIGSLPS 146
Cdd:cd15207   79 -VQGVSVAASVFTLVAIAVDRYRAVVhptEPKL----TNRQAFVIIVAIWVLALAimipqalvLEVKEYQFFR-GQTVHI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 147 CSTVLP--LYHKHYILFCTTVFTLL-LLTIVILYCRIyslvrtrSRRLTFRKNISKASRS-------SEKSLALLKTVII 216
Cdd:cd15207  153 CVEFWPsdEYRKAYTTSLFVLCYVApLLIIAVLYVRI-------GYRLWFKPVPGGGSASreaqaavSKKKVRVIKMLIV 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 347452693 217 VLSVFIACWAPLFILLLLDV--GCKVKTCQILYKAEYFLV--LAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15207  226 VVVLFALSWLPLHTVTMLDDfgNLSPNQREVLYVYIYPIAhwLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
5-278 1.40e-19

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 86.88  E-value: 1.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAG--------VAYIANLLLSGATTYKLTPaqwFLr 76
Cdd:cd14993    4 IVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSlfcmpltlLENVYRPWVFGEVLCKAVP---YL- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  77 egsMFVALSASVFSLLAIAIERYITM---LKMKLHngSNSSRSFLLISACWVISLILG-------GLPIMGWNCIGSLP- 145
Cdd:cd14993   80 ---QGVSVSASVLTLVAISIDRYLAIcypLKARRV--STKRRARIIIVAIWVIAIIIMlpllvvyELEEIISSEPGTITi 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 146 -SCSTVLP--LYHKHYILFCTTVFTLL-LLTIVILYCRIyslVRTRSRRLTFRKNISKASRSSEKSLA----LLKTVIIV 217
Cdd:cd14993  155 yICTEDWPspELRKAYNVALFVVLYVLpLLIISVAYSLI---GRRLWRRKPPGDRGSANSTSSRRILRskkkVARMLIVV 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 347452693 218 LSVFIACWAPLFIL-LLLDVGCKVKTC-QILYKAEY--FLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd14993  232 VVLFALSWLPYYVLsILLDFGPLSSEEsDENFLLILpfAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
7-276 8.73e-19

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 84.46  E-value: 8.73e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIAN---LLLSGATTYKLTPAQWFLREGSMFVA 83
Cdd:cd15351    6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIEtlfMLLLEHGVLVCRAPMLQHMDNVIDTM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  84 LSASVFSLL----AIAIERYITML-KMKLHNGSNSSRSFLLISACWVISLIlgglpimgwncigslpsCSTVLPLYHKHY 158
Cdd:cd15351   86 ICSSVVSSLsflgAIAVDRYITIFyALRYHSIMTLQRAVNAIAGIWLASTV-----------------SSTLFIVYYNSN 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 159 -ILFCTTV-FTLLLLTIVILYCRIYSLVRTRSRRLTfRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDV 236
Cdd:cd15351  149 aVILCLIVfFLFMLVLMLVLYIHMFILACRHSQSIS-SQQRRQCPHQQTASLKGAITLTILLGIFFLCWGPFFLHLTLIV 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 347452693 237 GC-KVKTCQILYKA-EYFLVLAVLNSGTNPIIYTLTNKEMRR 276
Cdd:cd15351  228 TCpTHPFCLCYFKYfNLFLILIICNSIIDPLIYAFRSQELRK 269
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
7-278 9.91e-19

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 84.17  E-value: 9.91e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVA-YIANLLLSGATTYKLTPAQWFLR------EGS 79
Cdd:cd15352    6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSnSLETIMIAVLNSGYLVISDQFIQhmdnvfDSM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  80 MFVALSASVFSLLAIAIERYITML-KMKLHNGSNSSRSFLLISACWVISLIlgglpimgwncigslpsCSTVLPLY--HK 156
Cdd:cd15352   86 ICISLVASICNLLAIAVDRYVTIFyALRYHSIMTVRKALVLIAVIWVVCIV-----------------CGIVFIVYseSK 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 157 HYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDV 236
Cdd:cd15352  149 TVIVCLITMFFAMLVLMATLYVHMFLFARLHVKRIAALPPAVDGAPQQRSCMKGAVTITILLGVFIVCWAPFFLHLILII 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 347452693 237 GCKVKTCQILYKAEY--FLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15352  229 SCPHNPYCLCYTSHFntYLVLIMCNSVIDPLIYAFRSLEMRKTF 272
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
6-278 1.04e-18

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 83.87  E-value: 1.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayIANLLLSGATTYKLTPAQWFLRE--GSMFVA 83
Cdd:cd15310    5 LSYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLL-----VATLVMPWVVYLEVTGGVWNFSRicCDVFVT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  84 L-----SASVFSLLAIAIERYITMLKMKLHN----GSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLY 154
Cdd:cd15310   80 LdvmmcTASILNLCAISIDRYTAVVMPVHYQhgtgQSSCRRVSLMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDF 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 155 hkhYILFCTTVFTLLLLTIVILYCRIYsLVRTRSRRLTfrkniskasrssekslallKTVIIVLSVFIACWAPLFILLLL 234
Cdd:cd15310  160 ---VIYSSVVSFYLPFGVTLLVYVRIY-VVLLREKKAT-------------------QMLAIVLGAFIVCWLPFFLTHIL 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 347452693 235 DVGCKvkTCQI---LYKAeyFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15310  217 NTHCQ--ACHVppeLYSA--TTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
6-278 1.25e-18

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 83.68  E-value: 1.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYI-ANLLLSGATTYKLTPAQWFLRE-----GS 79
Cdd:cd15350    5 EVFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTlENILIILADMGYLNRRGPFETKlddimDS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  80 MFV-ALSASVFSLLAIAIERYITML-KMKLHNGSNSSRSFLLISACWVIslilgglpimgwnCIGSlpSCSTVLPLYHKH 157
Cdd:cd15350   85 LFClSLLGSIFSILAIAADRYITIFhALRYHNIMTMRRTLVILAIIWTF-------------CGGS--GILMILFFHFVA 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 158 YILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALlkTVIIVLSVFIACWAPLFILLLLDVG 237
Cdd:cd15350  150 TVICFTVLFFLMLVLILCLYVHMFLLARSHARKIASLPNHHAQHQRSNMRGAI--TLTILLGVFVCCWAPFVLHLLLMMF 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 347452693 238 CKVKTCQILYKAEYFL--VLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15350  228 CPMNPYCACYRSLFQVngTLIMSHAVIDPAIYAFRSPELRNTF 270
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
6-278 6.20e-18

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 82.29  E-value: 6.20e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIAnLLLSGATTYKLTPAQWFLREGSMFVALS 85
Cdd:cd15068    5 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP-FAITISTGFCAACHGCLFIACFVLVLTQ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  86 ASVFSLLAIAIERYITM-LKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWN--------------CIGSLPSC--S 148
Cdd:cd15068   84 SSIFSLLAIAIDRYIAIrIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNncgqpkegknhsqgCGEGQVAClfE 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 149 TVLPLYHKHYILFcTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSS-EKSLALLKTVIIVLSVFIACWAP 227
Cdd:cd15068  164 DVVPMNYMVYFNF-FACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTlQKEVHAAKSLAIIVGLFALCWLP 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 347452693 228 LFILLLLDVGCKVKTCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15068  243 LHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
5-278 7.14e-18

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 81.77  E-value: 7.14e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVayianLLLSGATTYKLTpAQWFLRE------- 77
Cdd:cd15333    8 AVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSI-----LVMPISIVYTVT-GTWTLGQvvcdiwl 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  78 GSMFVALSASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHK 156
Cdd:cd15333   82 SSDITCCTASILHLCVIALDRYWAITDaVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEVSECVVNTDHI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 157 HYILFCTT-VFTLLLLTIVILYCRIYSLVRTRSRRLTfrkniskasrssekslallKTVIIVLSVFIACWAPLFILLLLD 235
Cdd:cd15333  162 LYTVYSTVgAFYIPTLLLIALYGRIYVEARARERKAT-------------------KTLGIILGAFIVCWLPFFIISLVL 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 347452693 236 VGCKVKTCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15333  223 PICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
3-278 9.92e-18

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 81.71  E-value: 9.92e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMY-YFIGNLALSDLLAGVayianLLLSGATTYKLTPAQWFLREGSMF 81
Cdd:cd15057    2 ITGCILYLLVLLTLLGNALVIAAVLRFRHLRSKVTnYFIVSLAVSDLLVAI-----LVMPWAAVNEVAGYWPFGSFCDVW 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  82 VAL-----SASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIM-GWNCIGSL--------PS 146
Cdd:cd15057   77 VSFdimcsTASILNLCVISVDRYWAISSpFRYERRMTRRRAFIMIAVAWTLSALISFIPVQlGWHRADDTsealalyaDP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 147 CSTVLPLYHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLT--------FRKNISKASRSSEKSLALLKTVIIVL 218
Cdd:cd15057  157 CQCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIARRQIRRIAaleraaqeSTNPDSSLRSSLRRETKALKTLSIIM 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 347452693 219 SVFIACWAPLFILLLLDVGCKVKT----CQILYKAEYFLVLAVLNSGTNPIIYTlTNKEMRRAF 278
Cdd:cd15057  237 GVFVCCWLPFFILNCVLPFCDLRTaqfpCVPDTTFIVFVWLGWANSSLNPIIYA-FNADFRKAF 299
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
6-278 1.59e-17

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 80.48  E-value: 1.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVayianLLLSGATTYKLTPAQWFLREG------S 79
Cdd:cd15067    4 VVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGS-----IVMPFSILHEMTGGYWLFGRDwcdvwhS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  80 MFV-ALSASVFSLLAIAIERYITMLKMKLHNGSNS-SRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTV-LPLYHK 156
Cdd:cd15067   79 FDVlASTASILNLCVISLDRYWAITDPISYPSRMTkRRALIMIALVWICSALISFPAIAWWRAVDPGPSPPNQcLFTDDS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 157 HYILFCTTVFTLL-LLTIVILYCRIYslvrtrsrrltfrkniskasRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLD 235
Cdd:cd15067  159 GYLIFSSCVSFYIpLVVMLFTYYRIY--------------------RAAAKEQKAAKTLGIVMGVFILCWLPFFVTNILI 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 347452693 236 VGCKvKTCQILYKAEYFLV--LAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15067  219 GFCP-SNCVSNPDILFPLVtwLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
7-278 2.04e-17

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 80.86  E-value: 2.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayIANLLLSGATTYKLTPaQWFLREGSMFVALS- 85
Cdd:cd15065    5 FLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLL-----VALLVMTFAVVNDLLG-YWLFGETFCNIWISf 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  86 ------ASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPI-MGW------------NCIGSLP 145
Cdd:cd15065   79 dvmcstASILNLCAISLDRYIHIKKpLKYERWMTTRRALVVIASVWILSALISFLPIhLGWhrlsqdeikglnHASNPKP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 146 SCS-TVLPLYHKHYILFCTTVFTLLLLTIvilYCRIYSLVRTRSRRL--------TFRKNISKASRSSEKSLALLK---- 212
Cdd:cd15065  159 SCAlDLNPTYAVVSSLISFYIPCLVMLLI---YSRLYLYARKHVVNIksqklpseSGSKFQVPSLSSKHNNQGVSDhkaa 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 347452693 213 -TVIIVLSVFIACWAPLFILLLLDVGCKVKTCQILYKAeyFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15065  236 vTLGIIMGVFLICWLPFFIINIIAAFCKTCIPPKCFKI--LTWLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
3-278 3.93e-17

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 79.32  E-value: 3.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayIANLLLSGATTYKLTpAQWFLREG--SM 80
Cdd:cd15331    2 LTSIILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLM-----VAVLVMPLSAVYEVS-QHWFLGPEvcDM 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 FVAL-----SASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPScstvlpLYH 155
Cdd:cd15331   76 WISMdvlccTASILHLVAIALDRYWAVTNIDYIRRRTAKRILIMIAVVWFVSLIISIAPLFGWKDEDDLDR------VLK 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 156 KHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRssekslallkTVIIVLSVFIACWAPLFILLLLD 235
Cdd:cd15331  150 TGVCLISQDYGYTIFSTVGAFYVPLLLMIIIYWKIYQAAKRERKAAR----------TLAIITGAFVVCWLPFFLVALVM 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 347452693 236 VGCkvKTCQILYKAE-YFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15331  220 PFC--GAWQISRFLEsFFLWLGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
5-278 4.73e-17

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 79.33  E-value: 4.73e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYklTPAQWFLRE---GSMF 81
Cdd:cd15061    3 ISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGY--WPLGSHLCDfwiSLDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  82 VALSASVFSLLAIAIERYITMLKMKLHNGSNSSR-SFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYIL 160
Cdd:cd15061   81 LLCTASILNLCCISLDRYFAITYPLKYRTKRSRRlAITMILAVWVISLLITSPPLVGPSWHGRRGLGSCYYTYDKGYRIY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 161 FCTTVFTLLLLTIVILYCRIYSLVRTRSRRLtfrkniskasrssekslallKTVIIVLSVFIACWAPLFILLLLDVGCKV 240
Cdd:cd15061  161 SSMGSFFLPLLLMLFVYLRIFRVIAKERKTA--------------------KTLAIVVGCFIVCWLPFFIMYLIEPFCDC 220
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 347452693 241 KTCQILYKAeyFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15061  221 QFSEALSTA--FTWLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
3-278 2.02e-16

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 77.31  E-value: 2.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVayianLLLSGATTYKLTpAQWFLREG--SM 80
Cdd:cd15329    2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVAL-----LVMPLAIIYELS-GYWPFGEIlcDV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 FVAL-----SASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPS-CSTVLPL 153
Cdd:cd15329   76 WISFdvllcTASILNLCAISVDRYLVITRpLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKNKVNDPGvCQVSQDF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 154 YHKHYILFCttVFTLLLLTIVILYCRIYSLVrtrsrrltfrKNISKASrssekslallKTVIIVLSVFIACWAPLFIL-L 232
Cdd:cd15329  156 GYQIYATFG--AFYIPLIVMLVLYYKIYRAA----------KSERKAI----------KTLGIIMGAFTLCWLPFFILaL 213
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 347452693 233 LLDVGCKVKTCQI-LYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15329  214 LRPFLKPIKCSCIpLWLSRLFLWLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
3-278 2.53e-16

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 77.09  E-value: 2.53e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGV----AYIANLLLsGATTYKLTPAQWFLreg 78
Cdd:cd15060    2 VTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIfvlpLNVAYFLL-GKWLFGIHLCQMWL--- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  79 SMFVAL-SASVFSLLAIAIERYitmlkMKLHNGSNSS------RSFLLISACWVISLILGGLPIMGWN-CIGSLPSCSTV 150
Cdd:cd15060   78 TCDILCcTASILNLCAIALDRY-----WAIHDPINYAqkrtlkRVLLMIVVVWALSALISVPPLIGWNdWPENFTETTPC 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 151 LPLYHKHYILFCTT-VFTLLLLTIVILYCRIYslvrtrsrrltfrkniskASRSSEKSLAllKTVIIVLSVFIACWAPLF 229
Cdd:cd15060  153 TLTEEKGYVIYSSSgSFFIPLLIMTIVYVKIF------------------IATSKERRAA--RTLGIIMGVFVVCWLPFF 212
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 347452693 230 ILLLLDVGCKvkTCQILYKAEYFLV-LAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15060  213 LMYVILPFCE--TCSPSAKVVNFITwLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
9-278 3.51e-16

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 76.97  E-value: 3.51e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   9 ILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVayianLLLSGATTYKLTPAQWFLreGSMFVAL---- 84
Cdd:cd15052    8 LLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGL-----LVMPLSILTELFGGVWPL--PLVLCLLwvtl 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  85 -----SASVFSLLAIAIERYITmLKMKLHNGSNSSRS--FLLISACWVIS-LILGGLPIMGWNCIGSLPSCSTVLPlYHK 156
Cdd:cd15052   81 dvlfcTASIMHLCTISLDRYMA-IRYPLRTRRNKSRTtvFLKIAIVWLISiGISSPIPVLGIIDTTNVLNNGTCVL-FNP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 157 HYILFCTTVFTLL-LLTIVILYCRIYSLVRTRsrrltfrkniSKASrssekslallKTVIIVLSVFIACWAPLFILLLLD 235
Cdd:cd15052  159 NFVIYGSIVAFFIpLLIMVVTYALTIRLLSNE----------QKAS----------KVLGIVFAVFVICWCPFFITNILT 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 347452693 236 VGCKVKTCQILYK-AEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15052  219 GLCEECNCRISPWlLSVFVWLGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
7-278 1.24e-15

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 75.43  E-value: 1.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFILI--CCCIILE---NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIaNLLlsgaTTYkLTPAQWFLreGSM- 80
Cdd:cd15049    1 VLICIatGSLSLVTvggNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSM-NLY----TVY-LVMGYWPL--GPLl 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 --------FVALSASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIG---SLPSCS 148
Cdd:cd15049   73 cdlwlaldYVASNASVMNLLLISFDRYFSVTRpLTYRAKRTPKRAILMIALAWVISFVLWAPAILGWQYFVgerTVPDGQ 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 149 TVLPLYHKHYILFCTTVFT--LLLLTIVILYCRIYslvrtrsrRLTFRKNisKASRssekslallkTVIIVLSVFIACWA 226
Cdd:cd15049  153 CYIQFLDDPAITFGTAIAAfyLPVLVMTILYWRIY--------RETARER--KAAR----------TLSAILLAFIITWT 212
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 347452693 227 PLFILLLLDVGCKVKTCQILYKAEYFlvLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15049  213 PYNILVLVSTFCAKCIPDTLWSFGYW--LCYINSTINPFCYALCNKTFRKTF 262
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
1-278 2.15e-15

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 74.54  E-value: 2.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   1 IKLTTVVFILICcciILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayIANLLLSGATTYKLTpAQWFLreGSM 80
Cdd:cd15326    3 LGLVLGAFILFA---IVGNILVILSVVCNRHLRIPTNYFIVNLAIADLL-----LSFTVLPFSATLEIL-GYWVF--GRI 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 F---------VALSASVFSLLAIAIERYITM-LKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNciGSLPSCSTV 150
Cdd:cd15326   72 FcdiwaavdvLCCTASILSLCAISIDRYIGVrHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGWK--EPAPPDDKV 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 151 LPLYHK-HYILFCTTVFTLL-LLTIVILYCRIYSLVRTRSRrltfrkniskasrssEKSLAllKTVIIVLSVFIACWAPL 228
Cdd:cd15326  150 CEITEEpFYALFSSLGSFYIpLIVILVMYCRVYIVALKFSR---------------EKKAA--KTLGIVVGMFILCWLPF 212
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 347452693 229 FILLLL-DVGCKVKTCQILYKAEYFlvLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15326  213 FIALPLgSLFSHLKPPETLFKIIFW--LGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
3-278 8.16e-15

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 73.05  E-value: 8.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIIlENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayIANLLLSGATTYKLTpAQWFLREG--SM 80
Cdd:cd15323    3 LAAVVGFLIVFTIV-GNVLVVIAVLTSRALRAPQNLFLVSLASADIL-----VATLVMPFSLANELM-GYWYFGQVwcNI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 FVAL-----SASVFSLLAIAIERYITMLKMKLHNGSNSSRSF-LLISACWVISLILGGLPI--MGWNCIGSL-PSCSTVl 151
Cdd:cd15323   76 YLALdvlfcTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVkAIIVTVWLISAVISFPPLisMYRDPEGDVyPQCKLN- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 152 plYHKHYILF-CTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFrkniskasrssekslallkTVIIVLSVFIACWAPLFI 230
Cdd:cd15323  155 --DETWYILSsCIGSFFAPCLIMILVYIRIYRVAKAREKRFTF-------------------VLAVVMGVFVVCWFPFFF 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 347452693 231 LLLLDVGCKvKTCQI---LYKaeYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15323  214 SYSLYGICR-EACEVpepLFK--FFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
3-278 8.40e-15

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 72.98  E-value: 8.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFlregSMFV 82
Cdd:cd15324    2 LIVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWC----AFYL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 AL-----SASVFSLLAIAIERYITMLKMKLHNGSNSSRSF-LLISACWVISLILGGLPIM-----GWNCigslpscstvL 151
Cdd:cd15324   78 ALdvlfcTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIkRMIAVVWVISAVISFPPLLmtkhdEWEC----------L 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 152 PLYHKHYILF-CTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFrkniskasrssekslallkTVIIVLSVFIACWAPLFI 230
Cdd:cd15324  148 LNDETWYILSsCTVSFFAPGLIMILVYCKIYRVAKMREKRFTF-------------------VLAVVMGVFVLCWFPFFF 208
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 347452693 231 LLLLDVGCKvKTCQI---LYKaeYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15324  209 TYSLHAVCR-KRCGIpdaLFN--LFFWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
3-278 3.02e-14

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 71.82  E-value: 3.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILeNIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGvayianLLLSGATTYKLTPAQWFLREG---- 78
Cdd:cd15055    3 LYIVLSSISLLTVLG-NLLVIISISHFKQLHTPTNLLLLSLAVADFLVG------LLVMPFSMIRSIETCWYFGDTfckl 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  79 ---SMFVALSASVFSLLAIAIERY------------ITMLKMKLhngsnssrsflLISACWVISLILGGLPIMGWNCIGS 143
Cdd:cd15055   76 hssLDYILTSASIFNLVLIAIDRYvavcdpllyptkITIRRVKI-----------CICLCWFVSALYSSVLLYDNLNQPG 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 144 LP---SC--STVLPLYHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRL-------TFRKNISKASRSSEKSLAll 211
Cdd:cd15055  145 LIrynSCygECVVVVNFIWGVVDLVLTFILPCTVMIVLYMRIFVVARSQARAIrshtaqvSLEGSSKKVSKKSERKAA-- 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 347452693 212 KTVIIVLSVFIACWAPLFILLLldVGCKVKTCQILYkaEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15055  223 KTLGIVVGVFLLCWLPYYIVSL--VDPYISTPSSVF--DVLIWLGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
16-278 3.57e-14

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 71.08  E-value: 3.57e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayIANLLLSGATTYKLTPAQWFLR------EGSMFVALSASVF 89
Cdd:cd15325   15 VLGNILVILSVACHRHLQTVTHYFIVNLAVADLL-----LTSTVLPFSAIFEILGYWAFGRvfcniwAAVDVLCCTASIM 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  90 SLLAIAIERYITM-LKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNciGSLPSCSTVLPLYHK-HYILFCTT-VF 166
Cdd:cd15325   90 SLCIISIDRYIGVsYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWK--EPAPEDETICQITEEpGYALFSALgSF 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 167 TLLLLTIVILYCRIYSLVRTRSRrltfrkniskasrssEKSLAllKTVIIVLSVFIACWAPLFILLLL-DVGCKVKTCQI 245
Cdd:cd15325  168 YLPLAIILVMYCRVYVVALKFSR---------------EKKAA--KTLGIVVGCFVLCWLPFFLVMPIgSIFPAYKPSDT 230
                        250       260       270
                 ....*....|....*....|....*....|...
gi 347452693 246 LYKAEYFlvLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15325  231 VFKITFW--LGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
5-278 6.07e-14

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 70.80  E-value: 6.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVA----YIANLLLS----GATTYKLtpaqWFLR 76
Cdd:cd15048    4 AVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVsmpfYIPYTLTGkwpfGKVFCKA----WLVV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  77 EgsmFVALSASVFSLLAIAIERYITMLKMKLHNGSNSS-RSFLLISACWVISLILGGLPIMGWNCI---GSLPSCSTVLP 152
Cdd:cd15048   80 D---YTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKrRTVLLMALVWILAFLLYGPAIIGWDLWtgySIVPTGDCEVE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 153 LYHKHYILF--CTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSE-------------KSLALLKTVIIV 217
Cdd:cd15048  157 FFDHFYFTFitSVLEFFIPFISVSFFNLLIYLNIRKRSRRRPLRSVPILPASQNPsrarsqreqvklrRDRKAAKSLAIL 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 347452693 218 LSVFIACWAPLFILLLLDVGCKvKTCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15048  237 VLVFLICWAPYTILTIIRSFCS-GSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
10-278 1.19e-13

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 69.59  E-value: 1.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  10 LICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQW---FLREGSMFValSA 86
Cdd:cd15322    9 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWceiYLALDVLFC--TS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  87 SVFSLLAIAIERYITMLKMKLHNGSNSSRSF-LLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILF-CTT 164
Cdd:cd15322   87 SIVHLCAISLDRYWSITQAIEYNLKRTPRRIkCIIFIVWVISAVISFPPLITIEKKSGQPEGPICKINDEKWYIISsCIG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 165 VFTLLLLTIVILYCRIYSLVRTRSRRLTFrkniskasrssekslallkTVIIVLSVFIACWAPLFILLLLDVGCKVKTCQ 244
Cdd:cd15322  167 SFFAPCLIMVLVYIRIYQIAKNREKRFTF-------------------VLAVVIGVFVICWFPFFFTYTLTAVCDCSVPE 227
                        250       260       270
                 ....*....|....*....|....*....|....
gi 347452693 245 ILYKaeYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15322  228 TLFK--FFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
9-278 1.44e-13

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 69.81  E-value: 1.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   9 ILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYI--ANLLLSGATTYKLTpaqWFLREGSMFVALSA 86
Cdd:cd15070    8 ILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIplAIVVSLGVTIHFYS---CLFMSCLLVVFTHA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  87 SVFSLLAIAIERYITM-LKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCST---------VLPLYHK 156
Cdd:cd15070   85 SIMSLLAIAVDRYLRVkLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTtplqcqftsVMRMDYM 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 157 HYILFcTTVFTLLLLTIVILYCRIYSLVRTR-SRRLTFRKNISKASRsseKSLALLKTVIIVLSVFIACWAPLFIlllld 235
Cdd:cd15070  165 VYFSF-FTWILIPLVIMCALYVDIFYIIRNKlSQNATGFRETGAFYG---REFKTAKSLALVLFLFAVCWLPLSI----- 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 347452693 236 VGCKVKTCQILYKAEYFL--VLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15070  236 INCVVYFNPKVPKIALYLgiLLSHANSMMNPIVYACKIKKFKETY 280
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
19-284 1.67e-13

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 69.48  E-value: 1.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  19 NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAG--VAYIANLLLSGATTYKL----TPAQWFLRegsmFVALSASVFSLL 92
Cdd:cd15306   18 NILVILAVSLEKKLQYATNYFLMSLAVADLLVGlfVMPIALLTILFEAMWPLplvlCPIWLFLD----VLFSTASIMHLC 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  93 AIAIERYITMLKMKLHNGSNS-SRSFLLISACWVISL-ILGGLPIMGWNCIGSLPSCSTVL--PLYHKHYILFCTTVFTL 168
Cdd:cd15306   94 AISLDRYIAIKKPIQASQYNSrATAFIKITVVWLISIgIAIPVPIKGIETDVDNPNNITCVltKERFGDFILFGSLAAFF 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 169 LLLTIVILycrIYSLvrtrSRRLTFRKNISKASRSSekslallKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCQILYK 248
Cdd:cd15306  174 TPLAIMIV---TYFL----TIHALRKQTITNEQRAS-------KVLGIVFFLFLLMWCPFFITNITSVLCDSCNQTTLQM 239
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 347452693 249 -AEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSC 284
Cdd:cd15306  240 lMEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITC 276
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
4-271 1.70e-13

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 69.38  E-value: 1.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   4 TTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGAT-TYKLTPAQWFLREGSMFV 82
Cdd:cd14964    1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTeASSRPQALCYLIYLLWYG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 ALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLL-ISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILF 161
Cdd:cd14964   81 ANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRViILGCWGVSLLLSIPPLVGKGAIPRYNTLTGSCYLICTTIYLT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 162 ctTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVgcKVK 241
Cdd:cd14964  161 --WGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKNLKATKSLLILVITFLLCWLPFSIVFILHA--LVA 236
                        250       260       270
                 ....*....|....*....|....*....|.
gi 347452693 242 TCQIL-YKAEYFLVLAVLNSGTNPIIYTLTN 271
Cdd:cd14964  237 AGQGLnLLSILANLLAVLASTLNPFIYCLGN 267
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
3-278 2.42e-13

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 68.82  E-value: 2.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayIANLLLSGATTYKLTPAQWFLREGSMFV 82
Cdd:cd15328    2 LVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVL-----VAALVMPLSLVHELSGRRWQLGRSLCQV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 ALS-------ASVFSLLAIAIERYITMLKMKLHNGSNSSR-SFLLISACWVISLILGGLPIM-GWN---------CIGSL 144
Cdd:cd15328   77 WISfdvlcctASIWNVTAIALDRYWSITRHLEYTLRTRRRiSNVMIALTWALSAVISLAPLLfGWGetysedseeCQVSQ 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 145 PSCSTVLPLYHKHYILFCttvftllllTIVILYCRIYslvrtrsrrltfrknisKASRsSEKSLALLktVIIVLSVFIAC 224
Cdd:cd15328  157 EPSYTVFSTFGAFYLPLC---------VVLFVYWKIY-----------------KAAQ-KEKRAALM--VGILIGVFVLC 207
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 347452693 225 WAPLFILLLLDVGCkvkTCQI--LYKAeYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15328  208 WIPFFLTELISPLC---SCDIppIWKS-IFLWLGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
10-287 2.81e-13

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 68.82  E-value: 2.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  10 LICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVA----YIANLLLSGATTYKLTPAQWFLREgsmFVALS 85
Cdd:cd15299   12 ILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVIsmnlFTTYIIMNRWALGNLACDLWLSID---YVASN 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  86 ASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCI---GSLPSCSTVLPLYHKHYILF 161
Cdd:cd15299   89 ASVMNLLVISFDRYFSITRpLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFvgkRTVPPDECFIQFLSEPIITF 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 162 CTTVFTLLL--LTIVILYCRIYslvrtrsrrltfrkniskasRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCK 239
Cdd:cd15299  169 GTAIAAFYLpvTIMTILYWRIY--------------------KETIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCD 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 347452693 240 VKTCQILYKAEYFLvlAVLNSGTNPIIYTLTNKEMRRAFiRIMSCCKC 287
Cdd:cd15299  229 SCIPKTYWNLGYWL--CYINSTVNPVCYALCNKTFRTTF-KMLLLCQC 273
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
3-278 3.69e-13

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 68.29  E-value: 3.69e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMFV 82
Cdd:cd15063    2 ISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 AL-SASVFSLLAIAIERYITMLKMKLHNGSNSS-RSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLyhkhyil 160
Cdd:cd15063   82 WMcTASILNLCAISLDRYLAITRPIRYPSLMSTkRAKCLIAGVWVLSFVICFPPLVGWNDGKDGIMDYSGSSS------- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 161 fCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLallKTVIIVLSVFIACWAPLFILLLLDVGCKV 240
Cdd:cd15063  155 -LPCTCELTNGRGYVIYSALGSFYIPMLVMLFFYFRIYRAARMETKAA---KTVAIIVGCFIFCWLPFFTVYLVRAFCED 230
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 347452693 241 KTCQILYKAeyFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15063  231 CIPPLLFSV--FFWLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
3-284 6.11e-13

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 67.62  E-value: 6.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILIcccIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTY------KLTPAqWFlr 76
Cdd:cd15305    5 LLILIIIIL---TIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYawplprYLCPI-WI-- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  77 egSMFVALS-ASVFSLLAIAIERYITMLKMKLHNGSNS-SRSFLLISACWVISL-ILGGLPIMGWNCIGSLPSCSTVLPL 153
Cdd:cd15305   79 --SLDVLFStASIMHLCAISLDRYVAIRNPIEHSRFNSrTKAMMKIAAVWTISIgISMPIPVIGLQDDEKVFVNGTCVLN 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 154 YHKHYILFCTTVFTLLLLTIVILYC-RIYSLVRTRSrrltfrknISKASRSSekslallKTVIIVLSVFIACWAPLFILL 232
Cdd:cd15305  157 DENFVLIGSFVAFFIPLIIMVITYClTIQVLQRQQA--------INNERRAS-------KVLGIVFFLFLIMWCPFFITN 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 347452693 233 LLDVGCKvKTCQILYKAEY---FLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSC 284
Cdd:cd15305  222 ILSVLCK-EACDQKLMEELlnvFVWVGYVSSGINPLVYTLFNKTYRRAFSNYIRC 275
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
6-278 7.75e-13

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 67.46  E-value: 7.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILE---NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLllsgaTTYKLTPAQWFLREGSMFV 82
Cdd:cd15302    2 LLALITAILSIITvigNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFY-----TVYVLNGDYWPLGWVLCDL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 ALS-------ASVFSLLAIAIERYITM-LKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWnciGSLPSCSTVLPlY 154
Cdd:cd15302   77 WLSvdytvclVSIYTVLLITIDRYCSVkIPAKYRNWRTPRKVLLIIAITWIIPALLFFISIFGW---QYFTGQGRSLP-E 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 155 HKHYILFCTTVFTLLLLTIVILYCRIYSLvrtrsrrLTFRKNISKASRSSEKSLallKTVIIVLSVFIACWAPLFILLLL 234
Cdd:cd15302  153 GECYVQFMTDPYFNMGMYIGYYWTTLIVM-------LILYAGIYRAANRARKAL---RTITFILGAFVICWTPYHILATI 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 347452693 235 DVGCKVKTC--QILYKAEYFlvLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15302  223 YGFCEAPPCvnETLYTISYY--LCYMNSPINPFCYALANQQFKKTF 266
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
6-278 8.38e-13

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 67.86  E-value: 8.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYI---ANLLLSGATTYKLTPAQWFLREGSMFV 82
Cdd:cd15058    5 LLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVplgATIVVTGKWQLGNFWCELWTSVDVLCV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 alSASVFSLLAIAIERYITmLKMKLHNGS--NSSRSFLLISACWVISLILGGLPIM----------GWNCIGSlPSCSTV 150
Cdd:cd15058   85 --TASIETLCVIAVDRYIA-ITRPLRYQVllTKRRARVIVCVVWIVSALVSFVPIMnqwwrandpeANDCYQD-PTCCDF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 151 LPlyHKHYILFCTTVFTLL-LLTIVILYCRIYsLVRTRSRRL----------------TFRKNISKASRSSEKSLAL--- 210
Cdd:cd15058  161 RT--NMAYAIASSVVSFYIpLLIMIFVYARVF-LIATRQLQLidkrrlrfqsecpapqTTSPEGKRSSGRRPSRLTVvke 237
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 347452693 211 ---LKTVIIVLSVFIACWAPLFILLLLDVgckvkTCQILYKAEYFLVLAVL---NSGTNPIIYTlTNKEMRRAF 278
Cdd:cd15058  238 hkaLKTLGIIMGTFTLCWLPFFIANIINV-----FNRNLPPGEVFLLLNWLgyiNSGLNPIIYC-RSPEFRTAF 305
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
7-277 1.09e-12

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 67.36  E-value: 1.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFILICCCI-ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIAnlllsgATTYKLTPAQW-FLREGSMFVAL 84
Cdd:cd15083    5 IFILIIGLIgVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCP------LMVISSFSGRWiFGKTGCDMYGF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  85 SASVF------SLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCI---GSLPSCS----TV 150
Cdd:cd15083   79 SGGLFgimsinTLAAIAVDRYLVITRpMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYvleGLLTSCSfdylSR 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 151 LPLYHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRL-TFRKNISKASRSSEKSLA-----LLKTVIIVLSVFIAC 224
Cdd:cd15083  159 DDANRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAMkEMAKRFSKSELSSPKARRqaevkTAKIALLLVLLFCLA 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 347452693 225 WAPLFILLLLDVGCKVKTCQILYKA--EYFLVLAVLnsgTNPIIYTLTNKEMRRA 277
Cdd:cd15083  239 WTPYAVVALIGQFGYLEVLTPLATAipAAFAKTSAI---YNPVIYAFSHPKFRRA 290
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
16-278 1.48e-12

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 66.36  E-value: 1.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVayianLLLSGATTYKLTpAQWFLreGSMF---------VALSA 86
Cdd:cd15062   15 IGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSF-----TVLPFSATLEVL-GYWAF--GRIFcdvwaavdvLCCTA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  87 SVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGWN--CIGSLPSCSTVlplYHKHYILFCT 163
Cdd:cd15062   87 SIMSLCVISVDRYIGVRYpLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWKepAPADEQACGVN---EEPGYVLFSS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 164 TVFTLL-LLTIVILYCRIYSLVRTRSRrltfrkniskasrssEKSLAllKTVIIVLSVFIACWAPLFILLLLDVGC-KVK 241
Cdd:cd15062  164 LGSFYLpLAIILVMYCRVYVVAFKFSR---------------EKKAA--KTLGIVVGAFVLCWFPFFVVLPLGSLFsTLK 226
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 347452693 242 TCQILYKAEYFlvLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15062  227 PPEPVFKVVFW--LGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
15-278 1.50e-12

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 66.68  E-value: 1.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  15 IILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTP-AQWFLREGSMFVALSASVFSLLA 93
Cdd:cd15197   14 IVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGdFACKVIRYLQVVVTYASTYVLVA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  94 IAIERYITMLK-MKLHNGSNSSRsfLLISACWVIS-------LILGGLPIMG---WNCIGSLPScstvlPLYHKHYILfC 162
Cdd:cd15197   94 LSIDRYDAICHpMNFSQSGRQAR--VLICVAWILSalfsipmLIIFEKTGLSngeVQCWILWPE-----PWYWKVYMT-I 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 163 TTVFTLLLLTIVILYCRIYsLVRTRSRR----LTFRKNISKASRSSEKS------LALLKTV---IIVLSVFIACWAPLF 229
Cdd:cd15197  166 VAFLVFFIPATIISICYII-IVRTIWKKskiqVTINKAGLHDGSSRRSSsrgiipRAKIKTIkmtFVIVTVFIICWSPYF 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 347452693 230 ILLLLDV-GCKVKTCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15197  245 VFDLLDVfGLLPRSKTKIAAATFIQSLAPLNSAINPLIYCLFSTHLCRPL 294
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
16-278 1.64e-12

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 66.48  E-value: 1.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYkltpaqWFLREG--SMFVAL-----SASV 88
Cdd:cd15321   21 IFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGY------WYFRKTwcEIYLALdvlfcTSSI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  89 FSLLAIAIERYITMLKMKLHNGSNSSRSF-LLISACWVISLILGGLPIMGWN----CIGSLPSCSTVLPLYhkhYILFCT 163
Cdd:cd15321   95 VHLCAISLDRYWSVSRAIEYNSKRTPRRIkCIILIVWLIAAVISLPPLIYKGkqkdEQGGLPQCKLNEEAW---YILSSS 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 164 TVFTLL-LLTIVILYCRIYSLVRTRSRRLTFrkniskasrssekslallkTVIIVLSVFIACWAPLFILLLLDVGCKvKT 242
Cdd:cd15321  172 IGSFFApCLIMILVYLRIYLIAKNREKRFTF-------------------VLAVVIGVFVLCWFPFFFSYSLGAICP-EL 231
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 347452693 243 CQILYKA-EYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15321  232 CKVPHSLfQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
6-278 2.46e-12

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 66.32  E-value: 2.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGvayianLLLSGATTYKLTPAQWFLreGSMFVAL- 84
Cdd:cd15317    5 IVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLG------LCVMPFSMIRTVETCWYF--GDLFCKFh 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  85 --------SASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIM------GWNCIGSLPSC-S 148
Cdd:cd15317   77 tgldlllcTTSIFHLCFIAIDRYYAVCDpLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYtgandeGLEEYSSEISCvG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 149 TVLPLYHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLT--------FRKNISKASRSSEKSLAllKTVIIVLSV 220
Cdd:cd15317  157 GCQLLFNKIWVLLDFLTFFIPCLIMIGLYAKIFLVARRQARKIQnmedkfrsSEENSSKASASRERKAA--KTLAIVMGI 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 347452693 221 FIACWAPLFILLLLDVGCKVKTCQILYKAeyFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15317  235 FLFCWLPYFIDTIVDEYSNFITPAIVFDA--VIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
7-278 2.61e-12

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 65.70  E-value: 2.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFILICcciILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayIANLLLSGATTYKLTPAQWFLR------EGSM 80
Cdd:cd15327    9 IFILMA---IVGNILVILSVACNRHLQTVTNYFIVNLAIADLL-----LSTTVLPFSATLEVLGFWAFGRvfcdiwAAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 FVALSASVFSLLAIAIERYITM-LKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNciGSLPSCSTVLPLYHKH-Y 158
Cdd:cd15327   81 VLCCTASILSLCVISVDRYVGVkHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWK--EPPPPDESICSITEEPgY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 159 ILFCTTVFTLL-LLTIVILYCRIYSLVRTRSRrltfrkniskasrssEKSLAllKTVIIVLSVFIACWAPLFILLLL-DV 236
Cdd:cd15327  159 ALFSSLFSFYLpLMVILVMYFRVYVVALKFSR---------------EKKAA--KTLAIVVGVFILCWFPFFFVLPLgSF 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 347452693 237 GCKVKTCQILYKAEYFlvLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15327  222 FPALKPSEMVFKVIFW--LGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
7-278 4.24e-12

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 65.34  E-value: 4.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFI-LICCCIILENIFVLLTIWKTKKFHRPMYYF-IGNLALSDLLAGVaY-----IANLLLSGattYKLTPAQWFLRE-- 77
Cdd:cd14980    5 IFIwIIGILALIGNILVIIWHISSKKKKKKVPKLlIINLAIADFLMGI-YlliiaIADQYYRG---RYAQYSEEWLRSpp 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  78 ---GSMFVALSA--SVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIM---GWNCIGSLPSCST 149
Cdd:cd14980   81 cllACFLVSLSSlmSVLMMLLITLDRYICIVYPFSNKRLSYKSAKIILILGWLFSIIFAAIPILysiNQPGDNRLYGYSS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 150 V-LPL-----YHKHYILFCTTVFTLLLLTIVILYCRIYSLVRtRSRrltfrKNISKASRSSEKSLALlKTVIIVLSVFIa 223
Cdd:cd14980  161 IcMPSnvsnpYYRGWLIAYLLLTFIAWIIICILYILIFISVR-KSR-----KSARRSSSKRDKRIAI-RLALILITDLI- 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 347452693 224 CWAPLFILLLLDVgCKVKTCQIlYKAEYFLVLAV-LNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd14980  233 CWLPYYIVIFSGL-LTSTEIDI-HVLQFIAILALpLNSAINPYLYTLTTPTFKRDF 286
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
5-277 5.18e-12

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 65.12  E-value: 5.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFIlICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTykltpaQWFLRE-GSMFVA 83
Cdd:cd15336    5 SVILI-IGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHK------RWIFGEkGCELYA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  84 LSASVF------SLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCI---GSLPSCS----T 149
Cdd:cd15336   78 FCGALFgitsmiTLLAISLDRYLVITKpLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGWSAYvpeGLLTSCTwdymT 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 150 VLPLYHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRL-----TFRKNISKASRSSEKSLALLKTVIIVLSVFIAC 224
Cdd:cd15336  158 FTPSVRAYTMLLFCFVFFIPLGIIIYCYLFIFLAIRSTGREVqklgsQDRKEKAKQYQRMKNEWKMAKIAFVVILLFVLS 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 347452693 225 WAPLFILLLLDVGCKVKTCQIlYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRA 277
Cdd:cd15336  238 WSPYACVALIAWAGYAHLLTP-YMKSVPAVIAKASAIYNPIIYAITHPKYREA 289
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
6-278 8.04e-12

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 64.29  E-value: 8.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayIANLLLSGATTYKLTPAQWFLR-EGSMFVAL 84
Cdd:cd15309    5 MLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLL-----VATLVMPWVVYLEVVGEWRFSRiHCDIFVTL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  85 -----SASVFSLLAIAIERYITMLKMKLHNGSNSS--RSFLLISACWVISLILGGLPIMGWNCIGSlPSCSTVLPLYhkh 157
Cdd:cd15309   80 dvmmcTASILNLCAISIDRYTAVAMPMLYNTRYSSkrRVTVMISVVWVLSFAISCPLLFGLNNTDQ-NECIIANPAF--- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 158 YILFCTTVFTLLLLTIVILYCRIYSLVrtrsrrltfrkniskasrssEKSLALLKTVIIVLSVFIACWAPLFILLLLDVG 237
Cdd:cd15309  156 VVYSSIVSFYVPFIVTLLVYVQIYIVL--------------------QKEKKATQMLAIVLGVFIICWLPFFITHILNMH 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 347452693 238 CKVKTCQILYKAeyFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15309  216 CDCNIPPALYSA--FTWLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
3-278 8.58e-12

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 64.23  E-value: 8.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVayianLLLSGATTYKLTpAQWFLREGS--M 80
Cdd:cd15330    2 ITSLFLGTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSV-----LVLPMAALYQVL-NKWTLGQVTcdL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 FVAL-----SASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGWN----------CIGSL 144
Cdd:cd15330   76 FIALdvlccTSSILHLCAIALDRYWAITDpIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWRtpedrsdpdaCTISK 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 145 PSCSTVLPLYHKHYIlfcttvftlLLLTIVILYCRIYslvrtrsrrltfrknisKASRSSEKSLallKTVIIVLSVFIAC 224
Cdd:cd15330  156 DPGYTIYSTFGAFYI---------PLILMLVLYGRIF-----------------KAAARERKTV---KTLGIIMGTFILC 206
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 347452693 225 WAPLFILLLLDVGCKVKTCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15330  207 WLPFFIVALVLPFCESTCHMPELLGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
19-278 8.60e-12

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 64.22  E-value: 8.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  19 NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYI-----ANLLLSGATTYKLTPAQWFLRegsmFVALSASVFSLLA 93
Cdd:cd15001   17 NSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVplktaEYFSPTWSLGAFLCKAVAYLQ----LLSFICSVLTLTA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  94 IAIERYITML-KMKLHNGSNSSRSFLLISACWVISLILG-------GLPIMGWNCIGSLPSC-----STVLPLYHKHYIL 160
Cdd:cd15001   93 ISIERYYVILhPMKAKSFCTIGRARKVALLIWILSAILAspvlfgqGLVRYESENGVTVYHCqkawpSTLYSRLYVVYLA 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 161 FCTTVftlllltivilycrIYSLVRTrsrrltfrkniskASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLL---DVG 237
Cdd:cd15001  173 IVIFF--------------IPLIVMT-------------FAYARDTRKQVIKMLISVVVLFAVCWGPLLIDNLLvsfDVI 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 347452693 238 CKVKTCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15001  226 STLHTQALKYMRIAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
11-278 1.13e-11

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 63.99  E-value: 1.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  11 ICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIA-NL--LLSGATTYKLTPAQWFLregSM-FVALSA 86
Cdd:cd15050   10 ISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPlNIvyLLESKWILGRPVCLFWL---SMdYVASTA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  87 SVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLiLGGLPIMGWNCIGSLP-------SCSTVLPLYHKHY 158
Cdd:cd15050   87 SIFSLFILCIDRYRSVQQpLKYLKYRTKTRASLMISGAWLLSF-LWVIPILGWHHFARGGervvledKCETDFHDVTWFK 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 159 ILFCTTVFTLLLLTIVILYCRIYSLVRTRsrrltfrkniskasRSSEKSLAllktviIVLSVFIACWAPLFILLLLDVGC 238
Cdd:cd15050  166 VLTAILNFYIPSLLMLWFYAKIFKAVNRE--------------RKAAKQLG------FIMAAFILCWIPYFILFMVIAFC 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 347452693 239 KvkTCqILYKAEYFLV-LAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15050  226 K--NC-CNENLHMFTIwLGYINSTLNPFIYPLCNENFKKTF 263
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
6-278 1.20e-11

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 64.30  E-value: 1.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGV-----AYIANLLLS----GATtykLTPAQWFLR 76
Cdd:cd15392    5 LMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVfcvpfSFIALLILQywpfGEF---MCPVVNYLQ 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  77 EGSMFValsaSVFSLLAIAIERYIT-MLKMKLHNGSNssRSFLLISACWVISLILgGLPIM-------GWNCIGSLPSCS 148
Cdd:cd15392   82 AVSVFV----SAFTLVAISIDRYVAiMWPLRPRMTKR--QALLLIAVIWIFALAT-ALPIAitsrlfeDSNASCGQYICT 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 149 TVLPLYHKHYI---LFCTTVFTLLLLTIVILYCRIysLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACW 225
Cdd:cd15392  155 ESWPSDTNRYIyslVLMILQYFVPLAVLVFTYTRI--GIVVWAKRTPGEAENNRDQRMAESKRKLVKMMITVVAIFALCW 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 347452693 226 APLFILLLL--DVGCKVKTCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15392  233 LPLNILNLVgdHDESIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
3-278 3.01e-11

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 62.55  E-value: 3.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGV----AYIANLLLSGATTYKLTPAQWFLREG 78
Cdd:cd15308    2 AALVGGVLLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALlvlpLYVYSEFQGGVWTLSPVLCDALMTMD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  79 SMFValSASVFSLLAIAIERYITM-LKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPscSTVLPLYHKH 157
Cdd:cd15308   82 VMLC--TASIFNLCAISVDRFIAVsVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLNNVPNRD--PAVCKLEDNN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 158 YILFCTTVFTLL-LLTIVILYCRIY-SLVRTRsrrltfrknisKAsrssekslalLKTVIIVLSVFIACWAPLFILLLLD 235
Cdd:cd15308  158 YVVYSSVCSFFIpCPVMLVLYCAMFrGLGRER-----------KA----------MRVLPVVVGAFLFCWTPFFVVHITR 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 347452693 236 VGCkvKTCQILYKAEYFLV-LAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15308  217 ALC--ESCSIPPQLISIVTwLGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
3-278 3.39e-11

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 62.50  E-value: 3.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLlsgatTYKLTpAQWFLREGSMFV 82
Cdd:cd15296    2 ILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYI-----PYVLT-GRWKFGRGLCKL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 AL-------SASVFSLLAIAIERYITMLKMKLHNG--SNSSRSFLLISACWVISLILGGLPIMGWNCI---GSLPSCSTV 150
Cdd:cd15296   76 WLvvdyllcTASVFNIVLISYDRFLSVTRAVSYRAqkGMTRQAVLKMVLVWVLAFLLYGPAIISWEYIaggSIIPEGECY 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 151 LPLYHKHYILFCTTVFTLLLLTIVILY--CRIYSLVRTRSRRLTFRKNISKasrssekSLAllktviIVLSVFIACWAPL 228
Cdd:cd15296  156 AEFFYNWYFLMTASTLEFFTPFISVTYfnLSIYLNIQKRRFRLSRDKKVAK-------SLA------IIVCVFGLCWAPY 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 347452693 229 FILLLLDVGCKvKTCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15296  223 TLLMIIRAACH-GHCVPDYWYETSFWLLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
5-278 3.60e-11

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 62.65  E-value: 3.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKtKKFHRPMYYFIGNLALSDLLAGVAYIANLLL-SGATTYKLTPAQWFLREGSMFVA 83
Cdd:cd14978    4 GYVLPVICIFGIIGNILNLVVLTR-KSMRSSTNVYLAALAVSDILVLLSALPLFLLpYIADYSSSFLSYFYAYFLPYIYP 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  84 LS-----ASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGgLPIMGWNCIGSLPSCSTVLPLYHKH 157
Cdd:cd14978   83 LAntfqtASVWLTVALTVERYIAVCHpLKARTWCTPRRARRVILIIIIFSLLLN-LPRFFEYEVVECENCNNNSYYYVIP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 158 YILFCTTVFTLLLLTIVIL---------------YCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFI 222
Cdd:cd14978  162 TLLRQNETYLLKYYFWLYAifvvllpfilllilnILLIRALRKSKKRRRLLRRRRRLLSRSQRRERRTTIMLIAVVIVFL 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 347452693 223 ACWAPLFILLLLDVGCKVKTCQILYKA--EYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd14978  242 ICNLPAGILNILEAIFGESFLSPIYQLlgDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
3-278 3.74e-11

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 62.73  E-value: 3.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMFV 82
Cdd:cd15134    2 PITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQYPWVFGEVFCKLRAFLS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 ALS--ASVFSLLAIAIERYITML-KMKLHNGSNSSRSFLLISACWVISLILgGLPIMGWNCIGSLP-------------S 146
Cdd:cd15134   82 EMSsyASVLTITAFSVERYLAIChPLRSHTMSKLSRAIRIIIAIWIIAFVC-ALPFAIQTRIVYLEypptsgealeesaF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 147 CSTV--LPLYHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIAC 224
Cdd:cd15134  161 CAMLneIPPITPVFQLSTFLFFIIPMIAIIVLYVLIGLQLRRSTLLRRGQRSVSGGRRSSQSRRTVLRMLVAVVVAFFIC 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 347452693 225 WAPLFILLLLDVGCKVKTC--QILYKAEYFL--VLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15134  241 WAPFHAQRLLTVYAKNMTPpyLFINRILFYIsgVLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
1-278 3.94e-11

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 62.29  E-value: 3.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   1 IKLTTVVFILIcccIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGvAYIANLLlsgaTTYkLTPAQWFLREGSM 80
Cdd:cd17790    3 IVITTGILSLV---TVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIG-AFSMNLY----TTY-ILMGHWALGTVAC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 -------FVALSASVFSLLAIAIERYITMLKMKLHNGSNS-SRSFLLISACWVISLILGGLPIMGWNCI---GSLPSCST 149
Cdd:cd17790   74 dlwlaldYVASNASVMNLLIISFDRYFSITRPLTYRAKRTpRRAAIMIGLAWLISFVLWAPAILFWQYLvgeRTVLAGQC 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 150 VLPLYHKHYILF--CTTVFTLLLLTIVILYCRIYslvrtrsrrltfrkniskasRSSEKSLALLKTVIIVLSVFIACWAP 227
Cdd:cd17790  154 YIQFLSQPIITFgtAIAAFYLPVTIMIILYWRIY--------------------RETIKEKKAARTLSAILLAFILTWTP 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 347452693 228 LFILLLLDVGCKVKTCQILYKAEYFlvLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd17790  214 YNIMVLVSTFCKDCVPKTLWELGYW--LCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
19-278 5.23e-11

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 62.26  E-value: 5.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  19 NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVayianLLLSGATTYKLTPAQWFlrEGSMFVA------LSASVFSLL 92
Cdd:cd15069   18 NVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGL-----FAIPFAITISLGFCTDF--HSCLFLAcfvlvlTQSSIFSLL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  93 AIAIERYITM-LKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCST--------------------VL 151
Cdd:cd15069   91 AVAVDRYLAIkVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFLGWNKAMSATNNSTnpadhgtnhscclisclfenVV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 152 PLYHKHYILFcTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNiskaSRSS-EKSLALLKTVIIVLSVFIACWAPLFI 230
Cdd:cd15069  171 PMSYMVYFNF-FGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDH----SRTTlQREIHAAKSLAIIVGIFALCWLPVHI 245
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 347452693 231 L----LLLDVGCKVKTCQILYKAeyfLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15069  246 LncitLFQPEFSKSKPKWAMNVA---ILLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
6-276 5.83e-11

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 62.08  E-value: 5.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLL--AGVAYIANLLLS------GATTYKLTPAqwfLRE 77
Cdd:cd15088    5 SVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLfmLGMPFLIHQFAIdgqwyfGEVMCKIITA---LDA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  78 GSMFvalsASVFSLLAIAIERYI------------TMLKMKLHNGSNSSRSFLLISACWVISLILGGlPIMGWNCIGSLP 145
Cdd:cd15088   82 NNQF----TSTYILTAMSVDRYLavvhpirstkyrTRFVAKLVNVGLWAASFLSILPVWVYSSLIYF-PDGTTFCYVSLP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 146 SCSTVLPLYHKHYILfcttvftlLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKslaLLKTVIIVLSVFIACW 225
Cdd:cd15088  157 SPDDLYWFTIYHFIL--------GFAVPLVVITVCYILILHRLARGVAPGNQSHGSSRTKR---VTKMVILIVVVFIVCW 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 347452693 226 APLFILLLLDVGCKVKTCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRR 276
Cdd:cd15088  226 LPFHVVQLVNLAMNRPTLAFEVAYFLSICLGYANSCLNPFVYILVSENFRK 276
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
5-278 1.23e-10

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 60.71  E-value: 1.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILIccciILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagVAYIANL--LLSGATTYKLTPAQW--FLREGSM 80
Cdd:cd15196    8 ATILVLA----LFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLL--VALFNVLpqLIWDITYRFYGGDLLcrLVKYLQV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 FvALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILgGLPIMGwncIGSLPS-------CSTVL-- 151
Cdd:cd15196   82 V-GMYASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAIAWVLSLLL-SIPQLF---IFSYQEvgsgvydCWATFep 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 152 PLYHKHYI-LFCTTVFTLLLLTIVILYCRIYSLV---RTRSRRLTFrkniskasrssekslallktviIVLSVFIACWAP 227
Cdd:cd15196  157 PWGLRAYItWFTVAVFVVPLIILAFCYGRICYVVwraKIKTVKLTL----------------------VVVACYIVCWTP 214
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 347452693 228 LFILLLLDVGCKVKTCQILYkAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15196  215 FFVVQMWAAWDPTAPIEGPA-FVIIMLLASLNSCTNPWIYLAFSGNLRRAL 264
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
6-282 1.70e-10

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 60.61  E-value: 1.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKF-HRPMYYFIgNLALSDLLAGVAYIAnLLLSGATTYKLTPAQ-----WFLREgs 79
Cdd:cd15295    5 FLMSLLALVIVLGNALVIIAFVVDKNLrHRSNYFFL-NLAISDFFVGAISIP-LYIPYTLTNRWDFGRglcvfWLVID-- 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  80 mFVALSASVFSLLAIAIERYITMLKMKLHNGSNSS--RSFLLISACWVISLILGGLPIMGWNCIGSLPScSTVLPLYHKH 157
Cdd:cd15295   81 -YLLCTASVYNIVLISYDRYQSVSNAVSYRNQQTAtlRIVTQMVAVWVLAFLVHGPAILVSDSWKTEDG-ECEPEFFSNW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 158 YILFCTTVFTLLLLTIVILYCRIYsLVRTRSRRLTFRKniskasrssekslaLLKTVIIVLSVFIACWAPLFILLLLDVG 237
Cdd:cd15295  159 YILAITSVLEFLVPVILVAYFNTQ-IYWSLWKRLRDRK--------------LAKSLAIILGTFAICWAPYSLFTIIRAA 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 347452693 238 CKVKTCQILYKAEYFLVLavLNSGTNPIIYTLTNKEMRRAFIRIM 282
Cdd:cd15295  224 CEKHRGSPWYNFAFWLQW--FNSFINPFLYPLCHKRFRKAFLKIF 266
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
16-277 1.74e-10

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 60.52  E-value: 1.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDL---LAGVAYIANLLLSGATTYKLTPAQWFLREGSMFValSASVFSLL 92
Cdd:cd15073   15 TISNGIVLVTFVKFRELRTPTNALIINLAVTDLgvsIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFG--MASIGLLT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  93 AIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYILFCTTVFTLLLLT 172
Cdd:cd15073   93 VVAVDRYLTICRPDLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPTGATCTINWRKNDSSFVSYTMSVIVVN 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 173 IVILYCRI---YSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCqilykA 249
Cdd:cd15073  173 FIVPLAVMfycYYNVSRFVKKVLASDCLESVNIDWTDQNDVTKMSVIMIVMFLVAWSPYSIVCLWASFGEPKKI-----P 247
                        250       260       270
                 ....*....|....*....|....*....|..
gi 347452693 250 EYFLVLAVLNSGT----NPIIYTLTNKEMRRA 277
Cdd:cd15073  248 PWMAIIPPLFAKSstfyNPCIYVIANKKFRRA 279
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
3-278 2.02e-10

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 60.32  E-value: 2.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayIANLLLSGATTYkLTPAQW----FLREG 78
Cdd:cd15335    2 LIVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFL-----VAVLVMPLSITY-IVMDTWtlgyFICEI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  79 SMFVAL---SASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILgGLPIMGWNCIGSLPSCSTVLpLY 154
Cdd:cd15335   76 WLSVDMtccTCSILHLCVIALDRYWAITDaIEYARKRTAKRAGLMILTVWTISIFI-SIPPLFWRNHHDANIPSQCI-IQ 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 155 HKH--YILFCTT-VFTLLLLTIVILYCRIYSlVRTRSRrltfrknisKASRssekslallkTVIIVLSVFIACWAPLFIL 231
Cdd:cd15335  154 HDHviYTIYSTFgAFYIPLTLILILYYRIYH-AASRER---------KAAR----------ILGLILGAFILSWLPFFIK 213
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 347452693 232 LLLdVGCKVKTCQILYkAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15335  214 ELI-VGLSVMTVSPEV-ADFLTWLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
16-278 2.85e-10

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 59.98  E-value: 2.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTY-KLTPAQWFLREGSMFVALSASVFSLLAI 94
Cdd:cd15297   15 IIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYwPLGPVVCDLWLALDYVVSNASVMNLLII 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  95 AIERYITMLKMKLHNGSNSSR-SFLLISACWVISLILGGLPIMGWNCIGSLPSCSTvlplyHKHYILFCTTVFTLLLLTI 173
Cdd:cd15297   95 SFDRYFCVTKPLTYPVKRTTKmAGMMIAAAWVLSFILWAPAILFWQFIVGGRTVPE-----GECYIQFFSNAAVTFGTAI 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 174 VILYCRIYSLVRTRSRrltfrknISKASRSSEKslaLLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCQILYKAEYFl 253
Cdd:cd15297  170 AAFYLPVIIMTVLYWQ-------ISRASSREKK---VTRTILAILLAFIITWTPYNVMVLINTFCASCIPNTVWTIGYW- 238
                        250       260
                 ....*....|....*....|....*
gi 347452693 254 vLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15297  239 -LCYINSTINPACYALCNATFKKTF 262
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
16-276 3.66e-10

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 59.54  E-value: 3.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWkTKKFHRPMYYF-IGNLALSDLLAGVaYIANLLLSGATT---YKLTPAQWFLREG---SMFVALSA-- 86
Cdd:cd15136   15 LVGNIIVLLVLL-TSRTKLTVPRFlMCNLAFADFCMGI-YLGLLAIVDAKTlgeYYNYAIDWQTGAGcktAGFLAVFSse 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  87 -SVFSLLAIAIERYITML-KMKLHNGSNSSRSFLLISACWVISLILGGLPIMGwncIGSLPSCSTVLPL-----YHKHYI 159
Cdd:cd15136   93 lSVFTLTVITLERWYAIThAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVG---VSSYSKTSICLPFetetpVSKAYV 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 160 LFCTTVFTLLLLTIVILYCRIYSLVRTRSRrltfrkniskASRSSEKSLAlLKTVIIVLSVFiACWAP-LFILLLLDVGC 238
Cdd:cd15136  170 IFLLLFNGLAFLIICGCYIKIYLSVRGSGR----------AANSNDTRIA-KRMALLVFTDF-LCWAPiAFFGLTAAFGL 237
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 347452693 239 KVKTcqiLYKAEYFLVLAV-LNSGTNPIIYTLTNKEMRR 276
Cdd:cd15136  238 PLIS---VSNAKILLVFFYpLNSCANPFLYAIFTKQFRR 273
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
15-278 3.89e-10

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 59.92  E-value: 3.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  15 IILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYI---ANLLLSGATTYKLTPAQWFLREGSMFValSASVFSL 91
Cdd:cd15959   14 IVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVppgATILLTGHWPLGTTVCELWTSVDVLCV--TASIETL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  92 LAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMG--W---------NCIGSLPSCSTVLPLyhKHYI 159
Cdd:cd15959   92 CAIAVDRYLAITNpLRYEALVTKRRARTAVCLVWAISAAISFLPIMNqwWrdgadeeaqRCYDNPRCCDFVTNM--PYAI 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 160 LFCTTVFTLLLLTIVILYCRIYsLVRTRSRRL-------------TFRKNISKASRSSEKSLAL-----LKTVIIVLSVF 221
Cdd:cd15959  170 VSSTVSFYVPLLVMIFVYVRVF-VVATRQVRLirkdkvrfppeesPPAESRPACGRRPSRLLAIkehkaLKTLGIIMGTF 248
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 222 IACWAPLFILLLLDVGCKVktcqiLYKAEYFLVLAVL---NSGTNPIIYTlTNKEMRRAF 278
Cdd:cd15959  249 TLCWLPFFVANIIKVFCRS-----LVPDPAFLFLNWLgyaNSAFNPIIYC-RSPDFRSAF 302
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
7-278 4.34e-10

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 59.52  E-value: 4.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFI-LICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVaY-----IANLLLSGatTYKLTPAQWflREGSM 80
Cdd:cd15137    5 VFIwVVGIIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMGV-YlliiaSVDLYYRG--VYIKHDEEW--RSSWL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 -----FVA-LS--ASVFSLLAIAIERYItMLKMKLHNGSNSSRSFLLISAC-WVISLILGGLPIMGWNCIGSLPSCSTV- 150
Cdd:cd15137   80 ctfagFLAtLSseVSVLILTLITLDRFI-CIVFPFSGRRLGLRRAIIVLACiWLIGLLLAVLPLLPWDYFGNFYGRSGVc 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 151 LPLY-HKHY-------ILFCTTVFTLLLLTIVILYCRIYSLVRTRsrrltfRKNISKASRSSEKSLALlKTVIIVLSVFi 222
Cdd:cd15137  159 LPLHiTDERpagweysVFVFLGLNFLAFVFILLSYIAMFISIRRT------RKAAASRKSKRDMAVAK-RFFLIVLTDF- 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 347452693 223 ACWAPLFILLLLdVGCKVKTCQILYKAEYFLVLAVlNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15137  231 LCWIPIIVIGIL-ALSGVPIPGEVYAWVAVFVLPI-NSALNPILYTLSTPKFRKKL 284
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
9-278 4.69e-10

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 59.48  E-value: 4.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   9 ILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVayianLLLSGATTYKLTPAQWF----LREGSMFVAL 84
Cdd:cd15071    8 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA-----LVIPLAIIINIGPQTEFysclMVACPVLILT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  85 SASVFSLLAIAIERYITM-LKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSC---------------- 147
Cdd:cd15071   83 QSSILALLAIAVDRYLRVkIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFGWNNLNAVERAwaanssmgelvikcqf 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 148 STVLPLYHKHYILFcTTVFTLLLLTIVILYCRIYSLVRTRSRRLTfRKNISKASRSSEKSLALLKTVIIVLSVFIACWAP 227
Cdd:cd15071  163 ETVISMEYMVYFNF-FVWVLPPLLLMLLIYLEVFYLIRKQLNKKV-SSSSSDPQKYYGKELKIAKSLALILFLFALSWLP 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 347452693 228 LFILLLLDVGCKV-KTCQILYKAEYFLVLAvlNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15071  241 LHILNCITLFCPScKKPMILTYIAIFLTHG--NSAMNPIVYAFRIKKFRTTF 290
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
7-278 4.86e-10

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 59.26  E-value: 4.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFILICCCI-ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDlLAGVAYIANLLLSGATTYKLTPaqwFLREGSMFVALS 85
Cdd:cd15337    5 IYIAIVGILgVIGNLLVIYLFSKTKSLRTPSNMFIINLAISD-FGFSAVNGFPLKTISSFNKKWI---WGKVACELYGFA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  86 ASVF------SLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCI---GSLPSC-----STV 150
Cdd:cd15337   81 GGIFgfmsitTLAAISIDRYLVIAKpLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYvpeGFQTSCtfdylSRD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 151 LPLYHKHYILFcTTVFTLLLLTIVILYCRIYSLVRTRSRRLT------FRKNISKASRSSEKSLALLKTVIIVLSVFIAC 224
Cdd:cd15337  161 LNNRLFILGLF-IFGFLCPLLIIIFCYVNIIRAVRNHEKEMTqtaksgMGKDTEKNDARKKAEIRIAKVAIILISLFLLS 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 347452693 225 WAPLFILLLLDVgckVKTCQIL--YKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15337  240 WTPYAVVALLGQ---FGPAYWItpYVSELPVMFAKASAIYNPIIYALSHPKFRAAL 292
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
3-278 4.92e-10

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 59.18  E-value: 4.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILIccciILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTY------KLTPAQWFLR 76
Cdd:cd15304    6 LTVIVIILT----IAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYrwplpsKLCAVWIYLD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  77 egsmFVALSASVFSLLAIAIERYITMLKMKLHNGSNS-SRSFLLISACWVISL-ILGGLPIMGWNCIGSLPSCSTVLpLY 154
Cdd:cd15304   82 ----VLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSrTKAFLKIIAVWTISVgISMPIPVFGLQDDSKVFKEGSCL-LA 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 155 HKHYILFCTTVFTL--LLLTIVILYCRIYSLVRTRSrrltfrkNISKASrssekslallKTVIIVLSVFIACWAPLFILL 232
Cdd:cd15304  157 DENFVLIGSFVAFFipLTIMVITYFLTIKSLQQSIS-------NEQKAS----------KVLGIVFFLFVVMWCPFFITN 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 347452693 233 LLDVGCKVKTCQILYKA--EYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15304  220 VMAVICKESCNEVVIGGllNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
6-278 4.97e-10

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 59.18  E-value: 4.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAG-VAYIANLLLSGATTykltpaqWFLRE------G 78
Cdd:cd15314    5 IFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGgLVMPPSMVRSVETC-------WYFGDlfckihS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  79 SMFVALS-ASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILG-GLPIMGWNCIGSLPS-------C- 147
Cdd:cd15314   78 SFDITLCtASILNLCFISIDRYYAVCQpLLYRSKITVRVVLVMILISWSVSALVGfGIIFLELNIKGIYYNhvaceggCl 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 148 ----------STVLPLYHKHYILFCTtvftlllltivilYCRIYSLVRTRSRRL-TFRKNISKASRSSEKSLAllKTVII 216
Cdd:cd15314  158 vffskvssvvGSVFSFYIPAVIMLCI-------------YLKIFLVAQRQARSIqSARTKSGASSSKMERKAT--KTLAI 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 347452693 217 VLSVFIACWAPLFILLLLDVGCKVKTCQILYkaEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15314  223 VMGVFLLCWTPFFLCNIIDPFINYSIPPVLI--EVLNWLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
16-278 5.21e-10

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 59.34  E-value: 5.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYI-----ANLLLSGATTYKLTPAQWFLREgsmfVALSASVFS 90
Cdd:cd15393   15 VVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIpfqfqAALLQRWVLPRFMCPFCPFVQV----LSVNVSVFT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  91 LLAIAIERYITMLKmKLHNGSNSSRSFLLISACWVISlILGGLP---------IMGWNCIGSLPSCSTVLP-----LYHK 156
Cdd:cd15393   91 LTVIAVDRYRAVIH-PLKARCSKKSAKIIILIIWILA-LLVALPvalalrveeLTDKTNNGVKPFCLPVGPsddwwKIYN 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 157 HYILFctTVFTLLLLTIVILYCRI----YSLVRTRSRRLTFRKNISKASRSsekslaLLKTVIIVLSVFIACWAPLFILL 232
Cdd:cd15393  169 LYLVC--VQYFVPLVIICYAYTRIavkiWGTKAPGNAQDVRDDEILKNKKK------VIKMLIIVVALFALCWLPLQTYN 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 347452693 233 LLDVGC----KVKTCQILYKAEYFlvLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15393  241 LLNEIKpeinKYKYINIIWFCSHW--LAMSNSCYNPFIYGLYNEKFKREF 288
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
5-278 5.34e-10

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 59.16  E-value: 5.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLL-----AGVAYIANLLLS---GATTYKLTPaqwFLR 76
Cdd:cd15203    4 ILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLlclvsLPFTLIYTLTKNwpfGSILCKLVP---SLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  77 EGSMFValsaSVFSLLAIAIERYITMLKmKLHNGSNSSRSFLLISACWVISLIL---------------GGLPIMGWNCI 141
Cdd:cd15203   81 GVSIFV----STLTLTAIAIDRYQLIVY-PTRPRMSKRHALLIIALIWILSLLLslplaifqelsdvpiEILPYCGYFCT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 142 GSLPSCST-------------VLPLYhkhYILFCttvftlllltivilYCRIYSLVRTRSRRLTFRKNISKASRSSEKS- 207
Cdd:cd15203  156 ESWPSSSSrliytisvlvlqfVIPLL---IISFC--------------YFRISLKLRKRVKKKRGKRTLSSRRRRSELRr 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 208 ----LALLktVIIVLsVFIACWAPL--------FILLLLDVGCKVKTCQILykaeyFLVLAVLNSGTNPIIYTLTNKEMR 275
Cdd:cd15203  219 krrtNRLL--IAMVV-VFAVCWLPLnlfnllrdFEPLPQIDGRHFYLIFLI-----CHLIAMSSACVNPLLYGWLNDNFR 290

                 ...
gi 347452693 276 RAF 278
Cdd:cd15203  291 KEF 293
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
3-278 5.36e-10

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 59.23  E-value: 5.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVA---------YIANLLLSGATTYKLTPaqw 73
Cdd:cd14997    2 LVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVcmpvalvetWAREPWLLGEFMCKLVP--- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  74 FLRegsmFVALSASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILgGLPIM--------GWNCIGSL 144
Cdd:cd14997   79 FVE----LTVAHASVLTILAISFERYYAICHpLQAKYVCTKRRALVIIALIWLLALLT-SSPVLfitefkeeDFNDGTPV 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 145 PSCST-VLPLYHKHYILFCTTVFTLLLLTIVilyCRIYSLVrtrSRRLtFRKNISKASRSSEKSLALLKT-------VII 216
Cdd:cd14997  154 AVCRTpADTFWKVAYILSTIVVFFVVPLAIL---SGLYSVI---CRRL-VGHPALESRRADAANRHTLRSrrqvvymLIT 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 347452693 217 VLSVFIACWAP-----LFILLLLDVGCKVKTCQILYKAEYFL-VLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd14997  227 VVVLFFVCLLPfrvvtLWIIFAPDEDLQALGLEGYLNLLVFCrVMVYLNSALNPILYNLMSTKFRSAF 294
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
16-278 1.73e-09

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 57.34  E-value: 1.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGV----AYIANLLLSGATTYKLTPAQWFLREgsmFVALSASVFSL 91
Cdd:cd15300   15 IVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIfsmnLYTSYILMGYWALGSLACDLWLALD---YVASNASVMNL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  92 LAIAIERYITMLKMKLHNGSNS-SRSFLLISACWVISLILGGLPIMGWNCI---GSLPSCSTVLPLYHKHYILF--CTTV 165
Cdd:cd15300   92 LVISFDRYFSITRPLTYRAKRTpKRAGIMIGLAWLISFILWAPPILCWQYFvgkRTVPERECQIQFLSEPTITFgtAIAA 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 166 FTLLLLTIVILYCRIYslvrtrsrrltfrkniskasRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCQI 245
Cdd:cd15300  172 FYIPVSVMTILYCRIY--------------------KETIKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCSDCIPLT 231
                        250       260       270
                 ....*....|....*....|....*....|...
gi 347452693 246 LYKAEYFLvlAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15300  232 LWHLGYWL--CYVNSTVNPMCYALCNKTFRKTF 262
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
6-278 1.80e-09

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 57.28  E-value: 1.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAyiaNLLLSGATTYKLtpaQWFLRE-------G 78
Cdd:cd15210    5 VWGIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAF---NLPLAASTFLHQ---AWIHGEtlcrvfpL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  79 SMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSF-LLISACWVISLILGGLPIMG-WNCIG---SLPSCStVLPL 153
Cdd:cd15210   79 LRYGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLaLMIAGTWIFSFGSFLPLWLGiWGRFGldpKVCSCS-ILRD 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 154 YHKH---YILFcttvftlLLLTIVILYCRIYSLVRTRSRRLTfrkniskasrssekslallKTVIIVLSVFIACWAPLFI 230
Cdd:cd15210  158 KKGRspkTFLF-------VFGFVLPCLVIIICYARREDRRLT-------------------RMMLVIFLCFLVCYLPITL 211
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 347452693 231 LLLLDvgcKVKTCQILYKAEYflVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15210  212 VNVFD---DEVAPPVLHIIAY--VLIWLSSCINPIIYVAMNRQYRQAY 254
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
3-278 3.05e-09

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 56.75  E-value: 3.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVayIANLLLSGATTYKLTPAQWFLREGSM-- 80
Cdd:cd15301    2 LIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGV--ISMPLFTVYTALGYWPLGYEVCDTWLai 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 -FVALSASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIG---SLPSCSTVLP-LY 154
Cdd:cd15301   80 dYLASNASVLNLLIISFDRYFSVTRpLTYRARRTTKKAAVMIASAWIISLLLWPPWIYSWPYIEgkrTVPAGTCYIQfLE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 155 HKHYILF--CTTVFTLLLLTIVILYCRIYSLVRTRSRRltfrkniskasrsSEKSLAllKTVIIVLSVFIACWAPLFILL 232
Cdd:cd15301  160 TNPYVTFgtALAAFYVPVTIMCILYWRIWRETKKRQKK-------------QESKAA--KTLSAILLAFIVTWTPYNVLV 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 347452693 233 LLDVGCKVKTCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15301  225 LIKAFFPCSDTIPTELWDFSYYLCYINSTINPLCYALCNAAFRRTY 270
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
6-278 3.79e-09

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 56.82  E-value: 3.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLS--------GATTYKLTPaqwfLRE 77
Cdd:cd15980    5 ASYLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDniiagwpfGSTVCKMSG----MVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  78 GsmfVALSASVFSLLAIAIERY---ITMLKMKLhngsNSSRSFLLISACWVISL-ILGGLPIMGW-----NCIGSLPSCS 148
Cdd:cd15980   81 G---ISVSASVFTLVAIAVDRFrciVYPFKQKL----TISTAVVIIVIIWVLAIaIMCPSAVMLHvqeekNYRVVLGSQN 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 149 TVLPLY-----------HKHY--ILFcTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVI 215
Cdd:cd15980  154 KTSPVYwcredwpnqemRKIYttVLF-ANIYLAPLSLIVIMYARIGITLFKTAMPHTGKHNQEQRHVVSRKKQKVIKMLL 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 347452693 216 IVLSVFIACWAPLFILLLLDVGCKVKTCQI----LYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15980  233 IVALLFILSWLPLWTLMMLSDYANLSPNQLqiinIYIYPFAHWLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
19-267 9.09e-09

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 55.46  E-value: 9.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  19 NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQW--FLREGSMFvALSASVFSLLAIAI 96
Cdd:cd14986   18 NGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLcrIVKYLQVV-GLFASTYILVSMSL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  97 ERYITMLKmKLHNGSNSSRSFLLISACWVISLILG--GLPIMGWNCIG-SLPSCSTVL--PLYHKHYILFCTTVFTLL-L 170
Cdd:cd14986   97 DRYQAIVK-PMSSLKPRKRARLMIVVAWVLSFLFSipQLVIFVERELGdGVHQCWSSFytPWQRKVYITWLATYVFVIpL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 171 LTIVILYCRIYSLVRTRSR-------RLTFRKNISKASRSSEKSL---ALLKTV---IIVLSVFIACWAPLFILLLLDV- 236
Cdd:cd14986  176 IILSYCYGRILRTIWIRSRqktdrpiAPTAMSCRSVSCVSSRVSLisrAKIKTIkmtLVIILAFILCWTPYFIVQLLDVy 255
                        250       260       270
                 ....*....|....*....|....*....|..
gi 347452693 237 -GCKVKTcqiLYKAEYFLVLAVLNSGTNPIIY 267
Cdd:cd14986  256 aGMQQLE---NDAYVVSETLASLNSALNPLIY 284
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
19-278 9.90e-09

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 55.34  E-value: 9.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  19 NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayIANLLLSGATTYkLTPAQWFLREGSMFVALSA-------SVFSL 91
Cdd:cd15334   18 NSLVITAIIVTRKLHHPANYLICSLAVTDFL-----VAVLVMPFSIMY-IVKETWIMGQVVCDIWLSVditcctcSILHL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  92 LAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILgGLPIMGWNCIGSLPSCSTVLPLYHKHYILFCTT-VFTLL 169
Cdd:cd15334   92 SAIALDRYRAITDaVEYARKRTPKHAGIMIAVVWIISIFI-SMPPLFWRHQTTSREDECIIKHDHIVFTIYSTFgAFYIP 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 170 LLTIVILYCRIYSlVRTRSRRLTFrkniskasrssekslallkTVIIVLSVFIACWAPLFILLLLDVGCkvKTCQILYKA 249
Cdd:cd15334  171 LALILILYYKIYR-AATRERKAAT-------------------TLGLILGAFVICWLPFFVKEVIVNTC--DSCYISEEM 228
                        250       260       270
                 ....*....|....*....|....*....|
gi 347452693 250 EYFLV-LAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15334  229 SNFLTwLGYINSLINPLIYTIFNEDFKKAF 258
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
3-278 1.40e-08

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 54.82  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYkltpaqWFLREG---- 78
Cdd:cd15202    2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNT------WIFGLFmchf 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  79 ---SMFVALSASVFSLLAIAIERYITMLKmKLHNGSNSSRSFLLISACWVISL-------ILGGLPIMGWNCIGSLPSCS 148
Cdd:cd15202   76 snfAQYCSVHVSAYTLTAIAVDRYQAIMH-PLKPRISKTKAKFIIAVIWTLALafalphaICSKLETFKYSEDIVRSLCL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 149 TVLP----LYHKHY--ILFCtTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSlaLLKTVIIVLSVFI 222
Cdd:cd15202  155 EDWPeradLFWKYYdlALFI-LQYFLPLLVISFAYARVGIKLWASNMPGDATTERYFALRRKKKK--VIKMLMVVVVLFA 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 347452693 223 ACWAPLFILLLL---DVGCKVKTCQILYKAeyFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15202  232 LCWLPFNIYVLLlssKPDYLIKTINAVYFA--FHWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
3-278 1.63e-08

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 54.78  E-value: 1.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLlagvAYIANLLLSGATTYKLTpaQWFLreGS--- 79
Cdd:cd14971    2 IVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADL----TFLLFCVPFTATIYPLP--GWVF--GDfmc 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  80 ------MFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISAC-WVISLILGG----LPIMGWNCIGSLPSCS 148
Cdd:cd14971   74 kfvhyfQQVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCiWVVSLAVAApvlaLHRLRNYTPGNRTVCS 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 149 TVLPLY-HKHYILFCTTVFTLLLLTIVILYCriYSLVRTRSRRLTFRKNISKASRSSEKSLAllKTVIIVLSVFIACWAP 227
Cdd:cd14971  154 EAWPSRaHRRAFALCTFLFGYLLPLLLICVC--YAAMLRHLWRVAVRPVLSEGSRRAKRKVT--RLVLVVVVLFAACWGP 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 347452693 228 LFILLLLDVGCKVKTCQILYKAEYFL-VLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd14971  230 IHAILLLVALGPFPLTYATYALRIWAhCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
3-278 1.69e-08

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 54.67  E-value: 1.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayianLLLSGATTyKLTPAQW--------- 73
Cdd:cd14979    2 LVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLL--------ILLVGLPV-ELYNFWWqypwafgdg 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  74 ------FLREGSMFvalsASVFSLLAIAIERYITM---LKMKLHNGSnsSRSFLLISACWVISLILGG------------ 132
Cdd:cd14979   73 gcklyyFLFEACTY----ATVLTIVALSVERYVAIchpLKAKTLVTK--RRVKRFILAIWLVSILCAIpilflmgiqyln 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 133 ----LPIMGWNCIGSLPSCSTVLPLYHKHYILFcttvFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSL 208
Cdd:cd14979  147 gplpGPVPDSAVCTLVVDRSTFKYVFQVSTFIF----FVLPMFVISILYFRIGVKLRSMRNIKKGTRAQGTRNVELSLSQ 222
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 347452693 209 ALLKTVIIVL----SVFIACWAPLFILLLLdVGCKVKTCQIL---YKAEYFL--VLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd14979  223 QARRQVVKMLgavvIAFFVCWLPFHAQRLM-FSYASKEDTFLfdfYQYLYPIsgILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
6-278 2.20e-08

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 54.36  E-value: 2.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICcciILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVA--------YIANLLLSGATTYKLTPaqwFLRe 77
Cdd:cd14992    8 VVIILVS---VVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFctpfnftyVVSLSWEYGHFLCKIVN---YLR- 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  78 gsmFVALSASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILG-------GLPIMGWNCIGSLPSCST 149
Cdd:cd14992   81 ---TVSVYASSLTLTAIAFDRYFAIIHpLKPRHRQSYTTTVIIIITIWVVSLLLAipqlyyaTTEVLFSVKNQEKIFCCQ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 150 VLP----LYHKHYILFCTTVFTLL-LLTIVILYCRIyslvrtrSRRLTFRKNISKASRSSEK-----SLALLKTVIIVLS 219
Cdd:cd14992  158 IPPvdnkTYEKVYFLLIFVVIFVLpLIVMTLAYARI-------SRELWFRKVPGFSIKEVERkrlkcKRRVIKMLVCVVV 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 347452693 220 VFIACWAPLFILLLL-DVGCKVKTCQILYKAEYFLV-LAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd14992  231 LFVICWLPFHLFFLLrDFFPLIMKEKHTLQVYYFLHwIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
19-278 2.89e-08

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 53.90  E-value: 2.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  19 NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYkltpaqWFLREG------SMFVALS-ASVFSL 91
Cdd:cd15312   18 NLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESC------WYFGDLfckihsSLDMMLStTSIFHL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  92 LAIAIERYITMLKmKLHNGSNSSRS----FLLIsaCWVISLILG-GLPIMGWNCIG-----SLPSCSTVLPL-YHKHYIL 160
Cdd:cd15312   92 CFIAVDRYYAVCD-PLHYRTKITTPvikvFLVI--SWSVPCLFAfGVVFSEVNLEGiedyvALVSCTGSCVLiFNKLWGV 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 161 FCTTVFTLL-LLTIVILYCRIYSLVRTRSRRLTFRKNI------SKASRSSEKSLAllKTVIIVLSVFIACWAPLFILLL 233
Cdd:cd15312  169 IASLIAFFIpGTVMIGIYIKIFFVARKHAKVINNRPSVtkgdskNKLSKKKERKAA--KTLSIVMGVFLLCWLPFFVATL 246
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 347452693 234 LDVGCKVKTCQILYKAeyFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15312  247 IDPFLNFSTPVDLFDA--LVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
5-278 3.90e-08

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 53.84  E-value: 3.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayIANLLLSGATTYKLTPAQWFLREG---SMF 81
Cdd:cd15390    4 SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLL-----ISAFNTVFNFTYLLYNDWPFGLFYckfSNF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  82 VA---LSASVFSLLAIAIERYITMLKMKLHNGSnSSRSFLLISACWVISLILgGLP--------IMGWNCIGSLPSCSTV 150
Cdd:cd15390   79 VAittVAASVFTLMAISIDRYIAIVHPLRPRLS-RRTTKIAIAVIWLASFLL-ALPqllystteTYYYYTGSERTVCFIA 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 151 LP---------LYHkhyILFCTTVFTLLLLTIVILYCRIyslvrtrSRRLTFRKNISKASRSSEKSLA----LLKTVIIV 217
Cdd:cd15390  157 WPdgpnslqdfVYN---IVLFVVTYFLPLIIMAVAYTRV-------GVELWGSKTIGENTPRQLESVRakrkVVKMMIVV 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 347452693 218 LSVFIACWAPL---FILLLLDVGCK-VKTCQILYKAEYFlvLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15390  227 VVIFAICWLPYhlyFILTYLYPDINsWKYIQQIYLAIYW--LAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
5-278 4.03e-08

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 53.75  E-value: 4.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAG---VAYIANLLLSGATTYkltpaqwflreGSMF 81
Cdd:cd15958    4 SLLMALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGllvVPFGATLVVRGRWLY-----------GSFF 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  82 VAL---------SASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIM--GWNCIGSL----- 144
Cdd:cd15958   73 CELwtsvdvlcvTASIETLCVIAIDRYLAITSpFRYQSLLTRARAKGIVCTVWAISALVSFLPIMmhWWRDEDDQalkcy 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 145 --PSCSTVLPlYHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRL---------TFRKNISKASRSSEKSLAL--- 210
Cdd:cd15958  153 edPGCCDFVT-NRAYAIASSIISFYIPLLIMIFVYLRVYREAKKQIKKIdkcegrfhnTLTGLGRKCKRRPSRILALreq 231
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 211 --LKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCQILYKaeYFLVLAVLNSGTNPIIYTlTNKEMRRAF 278
Cdd:cd15958  232 kaLKTLGIIMGVFTLCWLPFFLVNVVNVFNRELVPDWLFV--FFNWLGYANSAFNPIIYC-RSPDFRKAF 298
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
3-278 4.67e-08

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 53.45  E-value: 4.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLA--GVAY-IANLLLS----GATTYKLTPAQWFL 75
Cdd:cd14970    2 VIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFllGLPFlATSYLLGywpfGEVMCKIVLSVDAY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  76 regSMFvalsASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGgLPIM-----------GWNCIGS 143
Cdd:cd14970   82 ---NMF----TSIFCLTVMSVDRYLAVVHpVKSLRFRTPRKAKLVSLCVWALSLVLG-LPVIifartlqeeggTISCNLQ 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 144 LPSCSTVlplYHKHYILFCTTVFTLLLLTIVilyCRIYSLVrtrSRRLTFRKNISKA-SRSSEKSLALL-KTVIIVLSVF 221
Cdd:cd14970  154 WPDPPDY---WGRVFTIYTFVLGFAVPLLVI---TVCYSLI---IRRLRSSRNLSTSgAREKRRARRKVtRLVLVVVAVF 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 347452693 222 IACWAP--LFILLLLDVGCKVKTCQIlYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd14970  225 VVCWLPfhVFQIVRLLIDPPETLTVV-GVFLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
5-278 4.68e-08

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 53.42  E-value: 4.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAgvayIANLLLSGAttyKLTPAQWFLREGSMFVAL 84
Cdd:cd15089    4 TALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALA----TSTLPFQSA---KYLMETWPFGELLCKAVL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  85 S-------ASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGgLPIMGWNCIGSLPSCSTVL----- 151
Cdd:cd15089   77 SidyynmfTSIFTLTMMSVDRYIAVCHpVKALDFRTPAKAKLINICIWVLSSGVG-VPIMVMAVTKTPRDGAVVCmlqfp 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 152 --PLYHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTfrknisKASRSSEKSLA-LLKTVIIVLSVFIACWAPL 228
Cdd:cd15089  156 spSWYWDTVTKICVFIFAFVVPILVITVCYGLMILRLRSVRLL------SGSKEKDRNLRrITRMVLVVVAAFIICWTPI 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 347452693 229 FILLLLDVGCKVKTCQILYKAEYFLVLAV--LNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15089  230 HIFVIVWTLVDIDRRNPLVVAALHLCIALgyANSSLNPVLYAFLDENFKRCF 281
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
3-278 4.88e-08

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 53.19  E-value: 4.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHR--PMYYFIGNLALSDLlagvAYIANLLLSGATTYKLtpAQWFLreGSM 80
Cdd:cd15098    2 IVPVVFGLIFCLGVLGNSLVITVLARVKPGKRrsTTNVFILNLSIADL----FFLLFCVPFQATIYSL--PEWVF--GAF 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 F---------VALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISAC-WVISLILGgLPIMGWNCIGSLPS---- 146
Cdd:cd15098   74 MckfvhyfftVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLViWVLSLAMA-SPVAVHQDLVHHWTasnq 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 147 --CSTVLPL-YHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRltfrKNISKASRSSEKSLAllKTVIIVLSVFIA 223
Cdd:cd15098  153 tfCWENWPEkQQKPVYVVCTFVFGYLLPLLLITFCYAKVLNHLHKKL----KNMSKKSERSKKKTA--QTVLVVVVVFGI 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 347452693 224 CWAPLFILLLLdvgckVKTCQILYKAEYFLV------LAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15098  227 SWLPHHIIHLW-----VEFGDFPLTQASFVLritahcLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
6-278 5.02e-08

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 53.38  E-value: 5.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVaYIANLLLSGATTYKLTPAQWFLREGSMFVALS 85
Cdd:cd15401    5 GVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAV-YPYPLILLAIFHNGWTLGNIHCQISGFLMGLS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  86 --ASVFSLLAIAIERYITML-KMKLHNGSNSSRSFLLISACWVISLIlgglPIMGWNCIGSLP------SCSTVLPLYHK 156
Cdd:cd15401   84 viGSVFNITAIAINRYCYIChSLRYDKLYNMKKTCCYVCLTWVLTLA----AIVPNFFVGSLQydpriySCTFAQTVSSS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 157 HYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLtfRKNISKASRSSEksLALLKTVIIVLSVFIACWAPL-FILLLLD 235
Cdd:cd15401  160 YTITVVVVHFIVPLSIVTFCYLRIWVLVIQVKHRV--RQDSKQKLKAND--IRNFLTMFVVFVLFAVCWGPLnFIGLAVA 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 347452693 236 VG---CKVKTCQILYKAEYFlvLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15401  236 INplkVAPKIPEWLFVLSYF--MAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
4-278 5.24e-08

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 53.16  E-value: 5.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   4 TTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIanllLSGATTYKLTPAQWFLREGS---- 79
Cdd:cd14995    3 ATFLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAG----LPNEIESLLGPDSWIYGYAGclli 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  80 ---MFVALSASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLI-------LGGLPIM--GWNCIGSLP- 145
Cdd:cd14995   79 tylQYLGINASSLSITAFTIERYIAICHpMKAQFICTVSRAKKIICFVWIFTSLycspwlfLLDLSIKhyGDDIVVRCGy 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 146 --SCSTVLPLYHKHYILFcttvftllLLTIVILYCRIYSLvrtrsrrltfrknISKASRSSEKSLalLKTVIIVLSVFIA 223
Cdd:cd14995  159 kvSRHYYLPIYLADFVLF--------YVIPLLLAIVLYGL-------------IGRILFSSRKQV--TKMLAVVVVLFAL 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 347452693 224 CWAPLFILLLLDVGCKVKtcqilYKAEYFLVLA----VLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd14995  216 LWMPYRTLVVYNSFASPP-----YLDLWFLLFCrtciYLNSAINPILYNLMSQKFRAAF 269
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
16-279 5.48e-08

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 53.02  E-value: 5.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFHR--PMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLR-EGSMFVALS-ASVFSL 91
Cdd:cd14981   15 VLGNLLALIVLARSSKSHKwsVFYRLVAGLAITDLLGILLTSPVVLAVYASNFEWDGGQPLCDyFGFMMSFFGlSSLLIV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  92 LAIAIERYITMLKMKLHNGS-NSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCS-TVLPLYHKHY------ILFCT 163
Cdd:cd14981   95 CAMAVERFLAITHPFFYNSHvKKRRARLMLGAVWAFALLIASLPLLGLGSYVLQYPGTwCFLDFYSKNTgdaayaYLYSI 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 164 TVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDV-GCKVKT 242
Cdd:cd14981  175 LGLLILLVTLLCNLLVIITLLRMRRRKKRHRRSRRSARRQKRNEIQMVVLLLAITVVFSVCWLPLMIRVLINAtGDSEKN 254
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 347452693 243 CqilyKAEYFLV-LAVLNSGTNPIIYTLTNKEMRRAFI 279
Cdd:cd14981  255 G----KTDLLAVrMASWNQILDPWVYILLRKEVLRRLY 288
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
4-278 5.64e-08

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 52.98  E-value: 5.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   4 TTVVFILICCCI--ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVaYIANLLLSGA--TTYKLTPAQWFLREGS 79
Cdd:cd15402    1 TALACILIFTIVvdILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAI-YPYPLVLTSIfhNGWNLGYLHCQISGFL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  80 MFVALSASVFSLLAIAIERYITM---LKM-KLHNGSNSSRSFLLIsacWVISL--ILGGLPIMGWNCIGSLPSCSTVLPL 153
Cdd:cd15402   80 MGLSVIGSIFNITGIAINRYCYIchsLKYdKLYSDKNSLCYVLLI---WVLTVaaIVPNLFVGSLQYDPRIYSCTFAQSV 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 154 YHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNiskaSRSSEKSLALLKTVIIVLSVFIACWAPL-FILL 232
Cdd:cd15402  157 SSAYTIAVVFFHFILPIIIVTFCYLRIWILVIQVRRRVKPDNK----PKLKPHDFRNFVTMFVVFVLFAVCWAPLnFIGL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 347452693 233 LLDVGCKVKTCQI---LYKAEYFLvlAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15402  233 AVAVDPETIVPRIpewLFVASYYM--AYFNSCLNAIIYGLLNQNFRREY 279
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
7-268 6.25e-08

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 53.24  E-value: 6.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTP-----AQWFLREGSMF 81
Cdd:cd15388    6 VLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDITDRFRGPdvlcrLVKYLQVVGMF 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  82 valsASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGgLP---------------------IMGWNC 140
Cdd:cd15388   86 ----ASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVCVAWAISLILS-LPqvfifskvevapgvyecwacfIEPWGL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 141 IGSLPSCSTVLPLYHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTfrkniSKASRSSEKSLALLKTV----II 216
Cdd:cd15388  161 KAYVTWITLVVFVLPTLIITVCQVLIFKEIHINIYLKSQIIVAVVKKKQLLS-----SRASSVAEVSKAMIKTVkmtlVI 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 347452693 217 VLsVFIACWAPLFILLLLDVgCKVKTCQILYKAEYFLVLAVLNSGTNPIIYT 268
Cdd:cd15388  236 VL-VYVLCWAPFFLVQLWSV-WDPKAPTEGATFTILMLLASLNSCTNPWIYM 285
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
16-278 7.47e-08

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 52.71  E-value: 7.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTY-KLTPAQWFLREGSMFVALSASVFSLLAI 94
Cdd:cd15298   15 VVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYwPLGAVVCDLWLALDYVVSNASVMNLLII 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  95 AIERYITMLKMKLHNGSNSSR-SFLLISACWVISLILGGLPIMGWNCI---GSLPSCSTVLPLYHKHYILFCTTVFTLLL 170
Cdd:cd15298   95 SFDRYFCVTKPLTYPARRTTKmAGLMIAAAWVLSFVLWAPAILFWQFVvgkRTVPDNQCFIQFLSNPAVTFGTAIAAFYL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 171 LTIVILYCRIY-SLVRTRSRRLTfrkniskasrssekslallKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCQILYKA 249
Cdd:cd15298  175 PVVIMTVLYIHiSLASARERKVT-------------------RTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSI 235
                        250       260
                 ....*....|....*....|....*....
gi 347452693 250 EYFlvLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15298  236 GYW--LCYVNSTINPACYALCNATFKKTF 262
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
15-277 9.89e-08

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 52.55  E-value: 9.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  15 IILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGvayianLLLSGATTYKLTPAQWFLreGSMFVALS--------- 85
Cdd:cd15318   14 IVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLG------LTVLPFSTIRSVESCWYF--GDSFCRLHtcldtlfcl 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  86 ASVFSLLAIAIERYITMLKMKLHNGSNSSR-SFLLISACWVISLILGGLPIMG-------WNCIGSLPSCSTVLPLYHKH 157
Cdd:cd15318   86 TSIFHLCFISIDRHCAICDPLLYPSKFTIRvACIFIAAGWLVPTVYTSVFLYTkaveeglAELLTSVPCVGSCQLLYNKL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 158 YILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLAllKTVIIVLSVFIACWAPLFILLLLDVG 237
Cdd:cd15318  166 WGWLNFPVFFIPCLIMIGLYVKIFIVAKRQARAIASLLSDTNGASKRERKAA--KTLGIAVGVYLLCWLPFTIDTMVDSL 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 347452693 238 CKVKTCQILYkaEYFLVLAVLNSGTNPIIYTLTNKEMRRA 277
Cdd:cd15318  244 LNFITPPLLF--DIIIWFAYFNSACNPLIYVFSYPWFRKA 281
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
3-278 1.19e-07

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 51.92  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVL-LTIWKTKKFHRPMYYFigNLALSDLLAGV---AYIANLLLS-----GATTYKLTPAQW 73
Cdd:cd14974    2 VSLVLYALIFLLGLPGNGLVIwVAGFKMKRTVNTVWFL--NLALADFLFCLflpFLIVYIAMGhhwpfGSVLCKLNSFVI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  74 FLregSMFvalsASVFSLLAIAIERYITMLKMKL-HNGSNSSRSFLLISACWVISLILgglpimgwncigSLPS---CST 149
Cdd:cd14974   80 SL---NMF----ASVFLLTAISLDRCLLVLHPVWaQNHRTVRLASVVCVGIWILALVL------------SVPYfvfRDT 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 150 VLPLYHKHYILFCTTVFTLLLLTIVILYCRI---------------YSLVRTRSRRltfrKNISKASRSsekslalLKTV 214
Cdd:cd14974  141 VTHHNGRSCNLTCVEDYDLRRSRHKALTVIRflcgfllplliiaicYSVIAVKLRR----KRLAKSSKP-------LRVL 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 347452693 215 IIVLSVFIACWAPLFILLLLDVGCKVKTCQILYKAEYFLV-LAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd14974  210 LAVVVAFFLCWLPYHVFALLELVAAAGLPEVVLLGLPLATgLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
1-278 1.21e-07

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 52.01  E-value: 1.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   1 IKLTTVVFILIccciILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGV-----AYIANLL---LSGATTYKLTPAq 72
Cdd:cd15206    4 IPLYSVIFLLA----VVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVfcmpfTLVGQLLrnfIFGEVMCKLIPY- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  73 wflregSMFVALSASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGgLPIMGWNCI-----GSLPS 146
Cdd:cd15206   79 ------FQAVSVSVSTFTLVAISLERYFAICHpLKSRVWQTLSHAYKVIAGIWLLSFLIM-SPILVFSNLipmsrPGGHK 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 147 CSTVLPL--YHKHYILFCTTVFTLllltivilycrIYSLVRTRSRRLTFRKNISKASRssekslaLLKTVIIVLSVFIAC 224
Cdd:cd15206  152 CREVWPNeiAEQAWYVFLDLMLLV-----------IPGLVMSVAYGLISWTLLEAKKR-------VIRMLFVIVVEFFIC 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 347452693 225 WAPLFIL---LLLDVgcKVKTCQILYKAEYFL-VLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15206  214 WTPLYVIntwKAFDP--PSAARYVSSTTISLIqLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
3-276 1.24e-07

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 52.27  E-value: 1.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayianLLLS---------GATTYKLTPAQW 73
Cdd:cd14982    2 LFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLL--------FVLTlpfriyyylNGGWWPFGDFLC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  74 FLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISAC-WVIsLILGGLPIMgWNCIGSLPSCSTVLP 152
Cdd:cd14982   74 RLTGLLFYINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGvWIL-VLVASVPLL-LLRSTIAKENNSTTC 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 153 L---------YHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKAsrssekslalLKTVIIVLSVFIA 223
Cdd:cd14982  152 FeflsewlasAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSVRKRKA----------LRMILIVLAVFLV 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 224 CWAP------LFILLLLDVGCKVKTCQILYKA-EYFLVLAVLNSGTNPIIYTLTNKEMRR 276
Cdd:cd14982  222 CFLPyhvtriLYLLVRLSFIADCSARNSLYKAyRITLCLASLNSCLDPLIYYFLSKTFRK 281
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
3-278 1.37e-07

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 51.88  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDllagvAYIANLLLSGATTYKLTpaQWFLREGSMFV 82
Cdd:cd15091    2 IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALAD-----ALVTTTMPFQSTVYLMN--SWPFGDVLCKI 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 ALS-------ASVFSLLAIAIERYI------------TMLKMKLHNGSnssrSFLLISACWVISLILGGLPImgwNCIGS 143
Cdd:cd15091   75 VISidyynmfTSIFTLTMMSVDRYIavchpvkaldfrTPLKAKIINIC----IWLLSSSVGISAIVLGGTKV---REDVD 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 144 LPSCSTVLP----LYHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTfrknisKASRSSEKSLA-LLKTVIIVL 218
Cdd:cd15091  148 STECSLQFPdddySWWDTFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLL------SGSREKDRNLRrITRLVLVVV 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 347452693 219 SVFIACWAPLFILLLLDVGCKVKTCQILYKAEYFLV-LAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15091  222 AVFVVCWTPIHIFILVEALGSVSHSTAAVSSYYFCIaLGYTNSSLNPILYAFLDENFKRCF 282
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
7-278 1.86e-07

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 51.39  E-value: 1.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVaYIANLLLSGATTYKLTPAQWFLREGSMFVALS- 85
Cdd:cd15400    6 VLIFTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVAL-YPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSv 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  86 -ASVFSLLAIAIERYITMLKMKLHNGSNSSR-SFLLISACWVISLIlgglPIMGWNCIGSLP------SCSTVLPLYHKH 157
Cdd:cd15400   85 iGSIFNITGIAINRYCYICHSFAYDKLYSRWnTLLYVCLIWALTVV----AIVPNFFVGSLEydpriySCTFVQTASSSY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 158 YILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLtfrKNISKaSRSSEKSLALLKTVIIVLSVFIACWAPL-FILLLLDV 236
Cdd:cd15400  161 TIAVVVIHFIVPITVVSFCYLRIWVLVIQVRRKV---KSESK-PRLKPSDFRNFLTMFVVFVIFAICWAPLnLIGLAVAI 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 347452693 237 GCKVKTCQI---LYKAEYFlvLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15400  237 NPQEMAPKVpewLFVVSYF--MAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
6-278 2.03e-07

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 51.61  E-value: 2.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvaYIANLLLSGATTYKLT--PAQWFLREGS---M 80
Cdd:cd14985    5 ALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLV----FVLTLPLWATYTANQYdwPFGAFLCKVSsyvI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 FVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISA-CWVISLILgGLPIMGWNCIGSLPS-----CSTVLPLY 154
Cdd:cd14985   81 SVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCAlIWVVACLL-SLPTFLLRSLQAIENlnktaCIMLYPHE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 155 HKHYILFCTTVF---TLLLLTIVILYCRIYSLVRTRSRRltFRKNISKASRSsekslalLKTVIIVLSVFIACWAPLFIL 231
Cdd:cd14985  160 AWHFGLSLELNIlgfVLPLLIILTCYFHIARSLRKRYER--TGKNGRKRRKS-------LKIIFALVVAFLVCWLPFHFF 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 347452693 232 LLLDV--------GCKVKTCqILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd14985  231 KFLDFlaqlgairPCFWELF-LDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
2-278 2.21e-07

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 51.34  E-value: 2.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   2 KLTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGvayianllLSGATTYKLTPAQWFLREGSMF 81
Cdd:cd15082   14 TVLAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVS--------LTGGTISFLTNARGYFFLGVWA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  82 VALSA---------SVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLP 152
Cdd:cd15082   86 CVLEGfavtffgivALWSLAVLAFERFFVICRPLGNIRLQGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVSKIGTTCEP 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 153 LY-------HKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSsekslaLLKTVIIVLSVFIACW 225
Cdd:cd15082  166 NWysgnmhdHTYIITFFTTCFILPLGVIFVSYGKLLQKLRKVSNTQGRLGNARKPERQ------VTRMVVVMIVAFMVCW 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 347452693 226 APLFILLLLdvgckVKTCQILYKAEYFLVLAVLNSGT----NPIIYTLTNKEMRRAF 278
Cdd:cd15082  240 TPYAAFSIL-----VTAHPTIHLDPRLAAIPAFFSKTaavyNPIIYVFMNKQFRKCL 291
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
7-275 2.24e-07

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 51.51  E-value: 2.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFILICCCI-ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDL---LAGVAYIANLLLSGATTYKLTPAQWFLREGsMFV 82
Cdd:cd15074    5 IYLTVIGILsTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLgisVFGYPLAIISAFAHRWLFGDIGCVFYGFCG-FLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 ALSaSVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLP---SCS-----TVLPLY 154
Cdd:cd15074   84 GCC-SINTLTAISIYRYLKICHPPYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGSYGPEPfgtSCSidwtgASASVG 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 155 HKHYILFCTTVFTLL-LLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLAllKTVIIVLSVFIACWAPLFILLL 233
Cdd:cd15074  163 GMSYIISIFIFCYLLpVLIIVFSYVKIIRKVKSSRKRVAGFDSRSKRQHKIERKVT--KVAVLICAGFLIAWTPYAVVSM 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 347452693 234 LDVGCKVKTCQILykaeyFLVLAVL----NSGTNPIIYTLTNKEMR 275
Cdd:cd15074  241 WSAFGSPDSVPIL-----ASILPALfaksSCMYNPIIYLLFSSKFR 281
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
7-278 3.27e-07

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 50.98  E-value: 3.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFILICCciILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATT-YKLTPAQWFLREGSMFVALS 85
Cdd:cd15981    8 LFIFLLC--MVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITgWPFDNAMCKMSGLVQGMSVS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  86 ASVFSLLAIAIERY---ITMLKMKLhngsNSSRSFLLISACWVISLIL--------------GGLPIMGWNCIGSLPSCS 148
Cdd:cd15981   86 ASVFTLVAIAVERFrciVHPFRQKL----TLRKAIVTIVIIWVLALIImcpsavtltvtreeHHFMVDDYNNSYPLYSCW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 149 TVLP---LYHKHYILFCTTVFTLLLLTIVILYCRI-YSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIAC 224
Cdd:cd15981  162 EAWPdteMRKIYTTVLFSHIYLAPLTLIVIMYARIaFKLFKSSAPIRGSQGEEEEGRRVSKRKIKVINMLIIVALFFTLS 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 347452693 225 WAPLFILLLLDVGCKVKTCQILYKAEYFLV----LAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15981  242 WLPLWTLMLLTDYGHLSEDQLNLVTVYVFPfahwLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
5-278 4.71e-07

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 50.23  E-value: 4.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLL--AGVAYIAnlllsgattYKLTPAQWFLREGSMFV 82
Cdd:cd15971    4 TFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELfmLGLPFLA---------IQVALVHWPFGKAICRV 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 ALS-------ASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGgLPIMGWNCIGSL---PSCSTVL 151
Cdd:cd15971   75 VMTvdginqfTSIFCLTVMSIDRYLAVVHpIKSAKWRKPRTAKMINMAVWGVSLLVI-LPIMIYAGVQTKhgrSSCTIIW 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 152 PLYHK-HYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKslaLLKTVIIVLSVFIACWAPLFI 230
Cdd:cd15971  154 PGESSaWYTGFIIYTFILGFFVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKK---VTRMVSIVVAVFVFCWLPFYI 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 347452693 231 LLLLDVGCKVKTCQILYKA-EYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15971  231 FNVSSVSVSISPTPGLKGMfDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
7-277 5.61e-07

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 50.39  E-value: 5.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFILICCCIIL-----ENIFVLLTIWKTKKFHRP-MYYFIGNLALSDLLagvayIANLLLSGATTYKLTPAQW------- 73
Cdd:cd15382    1 LVSIIVYSVLFliaavGNLTVLLILLRNRRRKRSrVNILLMHLAIADLL-----VTFIMMPLEIGWAATVAWLagdflcr 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  74 ---FLRegsMFvALSASVFSLLAIAIERYITMLK-MKLHNGSNSSRsfLLISACWVISLI----------LGGLPIMGW- 138
Cdd:cd15382   76 lmlFFR---AF-GLYLSSFVLVCISLDRYFAILKpLRLSDARRRGR--IMLAVAWVISFLcsipqsfifhVESHPCVTWf 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 139 -NCI--GSLPScstvlPLYHKHYILFCTTVFTLL-LLTIVILYCRIYSLVRTRSR-----------RLTFRKN-ISKASR 202
Cdd:cd15382  150 sQCVtfNFFPS-----HDHELAYNIFNMITMYALpLIIIVFCYSLILCEISRKSKekkedvsekssSVRLRRSsVGLLER 224
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 347452693 203 SSEKSLALlkTVIIVLsVFIACWAPLFILLL---LDVGCKVKTCQILYKAEYflVLAVLNSGTNPIIYTLTNKEMRRA 277
Cdd:cd15382  225 ARSRTLKM--TIVIVL-VFIICWTPYFIMSLwywFDRESASKVDPRIQKGLF--LFAVSNSCMNPIVYGYFSIDLRRE 297
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
5-278 6.41e-07

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 49.99  E-value: 6.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLA-------GVAYIANLLLSGATTYKLTPAQWFLre 77
Cdd:cd15090    4 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAtstlpfqSVNYLMGTWPFGNILCKIVISIDYY-- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  78 gSMFValsaSVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISAC-WVISLILGgLPIMGWNCIGS---LPSCSTVLP- 152
Cdd:cd15090   82 -NMFT----SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCnWILSSAIG-LPVMFMATTKYrqgSIDCTLTFSh 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 153 --LYHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRltfrkNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFI 230
Cdd:cd15090  156 psWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVR-----MLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 347452693 231 LLLLDVGCKVKTCQILYKAEYF-LVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15090  231 YVIIKALVTIPETTFQTVSWHFcIALGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
3-278 6.71e-07

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 49.68  E-value: 6.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGV---AYIANLLLSGATTYKLTPAQWFlreGS 79
Cdd:cd15066    1 LKGFAMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALcamTFNASVEITGRWMFGYFMCDVW---NS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  80 MFVALS-ASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPI-MGW-------NCIGSLP-SCS 148
Cdd:cd15066   78 LDVYFStASILHLCCISVDRYYAIVQpLEYPSKMTKRRVAIMLANVWISPALISFLPIfLGWytteehlQYRKTHPdQCE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 149 TVLplyHKHYILFCTTVFTLL-LLTIVILYCRIYsLVRTRSRrltfrknisKASrssekslallKTVIIVLSVFIACWAP 227
Cdd:cd15066  158 FVV---NKIYALISSSVSFWIpCIVMIFTYYRIY-LEAKREH---------KAA----------KTLGIIMGAFILCWLP 214
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 347452693 228 LFILLLLDVGCKvKTCQ-------ILYKAEYFlvlavlNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15066  215 FFLWYVTTTLCG-DACPyppilvsILFWIGYF------NSTLNPLIYAYFNRDFREAF 265
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
6-147 1.04e-06

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 49.02  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvaY--------IANLLLSGAT-TYKLTPAQWFLr 76
Cdd:cd13954    5 VLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDIC----YtsvtvpkmLANLLSGDKTiSFSGCLTQLYF- 79
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 347452693  77 egsmFVALSASVFSLLAI-AIERYITMLKmKLHNGS--NSSRSFLLISACWVISLILGGLPIMgwnCIGSLPSC 147
Cdd:cd13954   80 ----FFSLGGTECFLLAVmAYDRYVAICH-PLHYPTimNKRVCILLAAGSWLIGFLNSLIHTV---LISQLPFC 145
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
3-278 1.16e-06

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 49.08  E-value: 1.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMFV 82
Cdd:cd15211    1 SLSTVYSFLAVSGTLANVLVIYLVVSFKKLQTTSNAFIVNGCVADLLVCAFWMPQEAVLGSTGTLLVLGYRLFREGLLFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 ALSASVFSLLAIAIERY--ITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHK---- 156
Cdd:cd15211   81 GLTVSLLSHSLIALNRYvlITKLPAVYQALYQKRNTEWMIALSWALALGLLLPWLTSFRYPTKSCHDSADGSFAVVsvls 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 157 -HY-ILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLT-----FRKNISKASRSSEKSLALlkTVIIVLSVFIACWAPLF 229
Cdd:cd15211  161 sRYpALLLAFTVLGQTALVLHCYFGIFRRVQISVKRVSvlnfqIVNNLPYSRPRKDKRLGL--YVLLVCCVFLLTTEPLV 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 347452693 230 ILLLLdvGCKVKTCQILYKAEYFLVLAVlnSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15211  239 WVSLA--GLFVPVPVALQTASWLLFCTL--FVLNPFLYTWKNEEFRRSF 283
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
19-277 1.18e-06

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 49.09  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  19 NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIAnlllsgATTYKLTPAQWFLreGSMFVALS---------ASVF 89
Cdd:cd15316   18 NLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMP------FSTVRSVESCWYF--GESFCTFHtccdvsfcyASLF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  90 SLLAIAIERYITMLKMKLHNGSNS-SRSFLLISACWVISLILGGLP-------------IMGWNCIGSlpsCSTVLplyH 155
Cdd:cd15316   90 HLCFISVDRYIAVTDPLVYPTKFTvSVSGICISVSWIFSLTYSFSVfytgvnddgleelVNALNCVGG---CQIIL---N 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 156 KHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKAS------RSSEKSLALLKTVIIVLSVFIACWAPLF 229
Cdd:cd15316  164 QNWVLVDFLLFFIPTFAMIILYGKIFLVAKQQARKIEMTSSKAESSsesykdRVARRERKAAKTLGITVIAFLVSWLPYL 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 347452693 230 ILLLLDVGCKVKTCQILYkaEYFLVLAVLNSGTNPIIYTLTNKEMRRA 277
Cdd:cd15316  244 IDVLIDAFMNFITPPYIY--EICCWCAYYNSAMNPLIYALFYPWFRKA 289
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
16-275 1.22e-06

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 49.05  E-value: 1.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGV-----AYIANLLLSGATTYKLTPAQWFLregsMFVALSASVFS 90
Cdd:cd15391   15 VGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALfcmpfTFTQIMLGHWVFPAPMCPIVLYV----QLVSVTASVLT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  91 LLAIAIERYITMLkMKLHNGSNSSRSFLLISACWVISLILGGLPIM-------GWNCIGSLpSCSTVLPLYHKHYILFCT 163
Cdd:cd15391   91 NTAIGIDRFFAVI-FPLRSRHTKSRTKCIIASIWAISFSLSSVQLFagrtqryGQYSEGRV-LCGESWPGPDTSRSAYTV 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 164 TVFTLLLLTIVILYCRIYSLVrtrSRRLTFRKNISKASRSSEK-----SLALLKTVIIVLSVFIACWAPLFILLLL-DVG 237
Cdd:cd15391  169 FVMLLTYIIPLLILTSTYGYV---GFRLWNRTAPGNADKGRDDmqiksKRKVIKMLVFVVLMFGICWLPLHLFNLVqDFS 245
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 347452693 238 CKVKTC-QILYKAEYFLV--LAVLNSGTNPIIYTLTNKEMR 275
Cdd:cd15391  246 TVFRNMpQHTTRLIYGAChwIAMSNSFVNPIIYLFMNDSFR 286
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
3-278 1.24e-06

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 49.14  E-value: 1.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSD--LLAGVAYIANLLLSGATTYKLTPAQWFLREGSM 80
Cdd:cd15970    2 LISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADelLMLSVPFLVTSTLLRHWPFGSLLCRLVLSVDAI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 fvALSASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGgLPIMGW-----NCIGSLpSCSTVLPLY 154
Cdd:cd15970   82 --NMFTSIYCLTVLSIDRYIAVVHpIKAARYRRPTVAKMVNLGVWVFSILVI-LPIIIFsntapNSDGSV-ACNMQMPEP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 155 HKHYI-LFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSsEKSLALLktVIIVLSVFIACWAPLFILLL 233
Cdd:cd15970  158 SQRWLaVFVVYTFLMGFLLPVIAICLCYILIIVKMRVVALKAGWQQRKRS-ERKITLM--VMMVVTVFVICWMPFYVVQL 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 347452693 234 LDVGCKVKTCQIlykAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15970  235 VSVFVGQHDATV---SQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
2-269 1.28e-06

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 49.05  E-value: 1.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   2 KLTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagVAYIANL-LLSGATTYKLTPAQWFLREGSM 80
Cdd:cd15385    1 KLEIAVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLV--VAFFQVLpQLCWDITYRFYGPDFLCRIVKH 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 FVALS--ASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGlPIMGWNCIGSLPSCSTV-------- 150
Cdd:cd15385   79 LQVLGmfASTYMLVMMTADRYIAICHPLKTLQQPTKRSYLMIGSAWALSFILST-PQYFIFSLSEIENGSGVydcwanfi 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 151 LPLYHKHYI------LFCTTVFTLLLLTIVILY---CRIYSLVRTRSRRLTFRKNISKASRSSEKSL--ALLKTV---II 216
Cdd:cd15385  158 VPWGIKAYItwitisIFVVPVIILLTCYGFICYniwRNIKCKTRRGLSDNALKNILLAVCVSSVKTIsrAKIRTVkmtFV 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 347452693 217 VLSVFIACWAPLFILLLLDVGCK--VKTCQILYKAEYFLVLAVLNSGTNPIIYTL 269
Cdd:cd15385  238 IVLAYIVCWAPFFTIQMWSVWDQnfPWDESENTAVTITALLASLNSCCNPWIYMF 292
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
3-267 1.31e-06

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 49.14  E-value: 1.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGV------AYIANLLLSGATTYKLTPAQWFlr 76
Cdd:cd14984    2 FLPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLtlpfwaVYAADGWVFGSFLCKLVSALYT-- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  77 egsmfVALSASVFSLLAIAIERYITMLKM-KLHNGSNSSRSFLLISACWVISLILGgLPIM----------GWNCIGSLP 145
Cdd:cd14984   80 -----INFYSGILFLACISIDRYLAIVHAvSALRARTLLHGKLTCLGVWALALLLS-LPEFifsqvseengSSICSYDYP 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 146 SCST----------------VLPLYhkhYILFCttvftlllltivilYCRIyslVRTRSRrltfrkniskaSRSSEKSLA 209
Cdd:cd14984  154 EDTAttwktllrllqnilgfLLPLL---VMLFC--------------YSRI---IRTLLR-----------ARNHKKHRA 202
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 347452693 210 LlKTVIIVLSVFIACWAPLFILLLLDV----GCKVKTCQILYKAEYFL----VLAVLNSGTNPIIY 267
Cdd:cd14984  203 L-RVIFAVVVVFFLCWLPYNIVLLLDTlqllGIISRSCELSKSLDYALqvteSLAFSHCCLNPVLY 267
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
16-278 1.32e-06

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 48.97  E-value: 1.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagVAYIANLLLSGATTYkltpAQWFLRE-GSMFVALSASVF---SL 91
Cdd:cd15086   15 FLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLL--VCVLGTPFSFAASTQ----GRWLIGEhGCRWYGFANSLFgivSL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  92 LAIAI---ERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKH------YILfC 162
Cdd:cd15086   89 ISLAVlsyERYCTLLRPTEADVSDYRKAWLGVGGSWLYSLLWTLPPLLGWSSYGPEGPGTTCSVQWTSRsansisYII-C 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 163 TTVFTLLLLTIVILYC--RIYSLVRTRSRrltfrknISK-ASRSSEKSLALLktVIIVLSVFIACWAPLFILLLLDV--- 236
Cdd:cd15086  168 LFIFCLLLPFLVMVYCygRLLYAIKQVGK-------INKsTARKREQHVLLM--VVTMVICYLLCWLPYGVMALLATfgk 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 347452693 237 -GCKVKTCQILYKaeyflVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15086  239 pGLVTPVASIVPS-----ILAKSSTVVNPIIYVFMNKQFYRCF 276
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
5-278 1.41e-06

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 48.96  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAY----IANLL----LSGATTYKLTPaqwFLR 76
Cdd:cd14977    4 MSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCvplnAYNLLtkdwLFGDVMCKLVP---FIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  77 EGSMFValsaSVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCI-------GSLPSC- 147
Cdd:cd14977   81 VTSLGV----TVFSLCALSIDRYRAAVNsMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTVAressldnSSLTVCi 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 148 ---STVLPLYHKHY-------ILFCTTVFTLLlltivilycrIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIV 217
Cdd:cd14977  157 mkpSTPFAETYPKArswwlfgCYFCLPLAFTA----------VCYLLMARTLIRAAKEYTRGTKKHMKQRRQLAKTVLCL 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 347452693 218 LSVFIACWAPLFIL----LLLDVGCKVKTCQILYKAEYF-LVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd14977  227 VLVFAFCWLPEHISnilrATLYNEVLIDTRSTLDILDLIgQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
7-278 1.53e-06

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 48.62  E-value: 1.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVaYIANLLLSGATTYKLTPAQWFLREGSMFVALS- 85
Cdd:cd15209    6 VLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAI-YPYPLILHAIFHNGWTLGQLHCQASGFIMGLSv 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  86 -ASVFSLLAIAIERYITML-KMKLHNGSNSSRSFLLISACWVISLiLGGLPIMgwnCIGSLP------SCSTVLPLYHKH 157
Cdd:cd15209   85 iGSIFNITAIAINRYCYIChSLQYDRLYSLRNTCCYLCLTWLLTV-LAVLPNF---FIGSLQydpriySCTFAQTVSTVY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 158 YILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLallkTVIIVLSVFIACWAPL-FILLLLDV 236
Cdd:cd15209  161 TITVVVIHFLLPLLIVSFCYLRIWVLVLQVRQRVKPDQRPKLKPADVRNFL----TMFVVFVLFAVCWAPLnFIGLAVAI 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 347452693 237 GCKVKTCQI---LYKAEYFLvlAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15209  237 NPKEMAPKIpewLFVASYFM--AYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
38-278 1.84e-06

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 48.85  E-value: 1.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  38 YFIGNLALSDLLAGVayianLLLSGATTYKLTPAQWFLREGSMFVAL-----SASVFSLLAIAIERYITMLK-MKLHNGS 111
Cdd:cd15320   39 FFVISLAVSDLLVAV-----LVMPWKAVAEIAGFWPFGSFCNIWVAFdimcsTASILNLCVISVDRYWAISSpFRYERKM 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 112 NSSRSFLLISACWVISLILGGLPI-MGW---------------------NCIGSLPSCSTVLPLYHKHYIlfcttvftlL 169
Cdd:cd15320  114 TPKVAFIMISVAWTLSVLISFIPVqLNWhkakptsfldlnaslrdltmdNCDSSLNRTYAISSSLISFYI---------P 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 170 LLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLA-----------------------LLKTVIIVLSVFIACWA 226
Cdd:cd15320  185 VAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQNSTGnrgsgdcqqpessfkmsfkretkVLKTLSVIMGVFVCCWL 264
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 347452693 227 PLFILLLLDVGCKVKTCQIL----YKAEYFLVLAVLNSGTNPIIYTLtNKEMRRAF 278
Cdd:cd15320  265 PFFILNCMVPFCKPTSTEPFcissTTFDVFVWFGWANSSLNPIIYAF-NADFRKAF 319
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
6-278 2.62e-06

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 48.24  E-value: 2.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCI----ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLS--------GATTYKLTPaqw 73
Cdd:cd15205    1 TAFVITYVLIfvlaLFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQnissnwlgGAFMCKMVP--- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  74 FLREgsmfVALSASVFSLLAIAIERY---ITMLKMKLHngSNSSRSFLLISACWVISLILGGL------------PIMGW 138
Cdd:cd15205   78 FVQS----TAVVTSILTMTCIAVERHqgiVHPLKMKWQ--YTNRRAFTMLGLVWIVSVIVGSPmlfvqqlevkydFLYEK 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 139 NCIGSLPSCSTvlPLYHKHYILFCTTVFTLL-LLTIVILYCRI-YSL-VRTR-----SRRLTFRKNISKASRSSEKSLAL 210
Cdd:cd15205  152 RHVCCLERWYS--PTQQKIYTTFILVILFLLpLTTMLFLYSRIgYELwIKKRvgdasVLQTIHGIEMSKISRKKKRAVKM 229
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 347452693 211 LKTVIIVLSVfiaCWAPLFILLL------LDVGCKVKTCQILYKAeyFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15205  230 MVTVVLLFAV---CWAPFHVVHMmieysnLENKYDGVTIKLIFAI--VQLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
5-278 3.75e-06

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 47.55  E-value: 3.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQW--FLREGSMFV 82
Cdd:cd15357    4 SLVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEVYEMWSNYPFLFGPVgcYFKTALFET 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 ALSASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISlILGGLPIMGWNCI-------GSL----PSCSTV 150
Cdd:cd15357   84 VCFASILSVTTVSVERYVAILHpFRAKLNSTRERALKIIVVLWVLS-VLFSIPNTSIHGIklqyfpnGTLipdsATCTVV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 151 LPLYHKHYILFCTTVFTLLL--LTIVILYCrIYSLVRTRSRRLTFRKNISKASRSSEKSLAllKTVIIVLSVFIACWAPL 228
Cdd:cd15357  163 KPLWIYNLIIQITSLLFYVLpmGVISVLYY-LMGLKLRGDKSLEADEMNVNIQRPSRKSVT--KMLFVLVLVFAICWAPF 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 347452693 229 FILLLLDVGCKVKTCQIlykAEYFLVLAV-------LNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15357  240 HVDRLFFSFVVEWTEPL---ANVFNLIHVvsgvffyLSSAVNPIIYNLLSRRFRTAF 293
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
6-275 4.20e-06

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 47.44  E-value: 4.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayianLLLSG---ATTYkLTPAQWFLREGSM-- 80
Cdd:cd14999    4 TVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLL--------YLLTIpfyVSTY-FLKKWYFGDVGCRll 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 ----FVALSASVFSLLAIAIERYITMLK-MKLHNGSNSSRSfLLISACWVISLILgGLPIM-------GWNCIGSLPSC- 147
Cdd:cd14999   75 fsldFLTMHASIFTLTVMSTERYLAVVKpLDTVKRSKSYRK-LLAGVIWLLSLLL-TLPMAimirlvtVEDKSGGSKRIc 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 148 -STVLPLYHKHYI-LFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRkniSKASRSSEKSLALLKTVIIvlsVFIACW 225
Cdd:cd14999  153 lPTWSEESYKVYLtLLFSTSIVIPGLVIGYLYIRLARKYWLSQAAASNS---SRKRLPKQKVLKMIFTIVL---VFWACF 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 347452693 226 APLFILLLLD-------VGCKVKTCqilykAEYFLV-LAVLNSGTNPIIYTLTNKEMR 275
Cdd:cd14999  227 LPFWIWQLLYlyspslsLSPRTTTY-----VNYLLTcLTYSNSCINPFLYTLLTKNYK 279
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
3-278 4.28e-06

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 47.29  E-value: 4.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLL--------AGVAYIANLLLSGATTYKLTpaqWF 74
Cdd:cd15096    2 VVPVIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLfvvfcvpfTATDYVLPTWPFGDVWCKIV---QY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  75 LregsMFVALSASVFSLLAIAIERYITMLKmklHNGSNSSRS----FLLISACWVISLIlGGLPIM---------GWNCI 141
Cdd:cd15096   79 L----VYVTAYASVYTLVLMSLDRYLAVVH---PITSMSIRTerntLIAIVGIWIVILV-ANIPVLflhgvvsygFSSEA 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 142 GSLPSCSTVLPL-YHKHYILFCTTVFTLLLLTIVILYCRIysLVRTRSRRLTFRKNISKASRSSEKslaLLKTVIIVLSV 220
Cdd:cd15096  151 YSYCTFLTEVGTaAQTFFTSFFLFSYLIPLTLICVLYMLM--LRRLRRQKSPGGRRSAESQRGKRR---VTRLVVVVVVV 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 221 FIACWAPLFILLLLDvGCKVKTCQILYKAEYFL--VLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15096  226 FAICWLPIHIILLLK-YYGVLPETVLYVVIQILsnCLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
6-278 5.37e-06

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 47.12  E-value: 5.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIIL----ENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIA-NLLLSGATTYKLTPAQWFLREGSM 80
Cdd:cd15399    1 IVLILAYCSIILlgvvGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPfTLVYTLLDEWKFGAVLCHLVPYAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 FVALSASVFSLLAIAIERYITMLkMKLHNGSNSSRSFLLISACWVISLILGG-LPIMGWNCIGSLPS------CSTVLPL 153
Cdd:cd15399   81 ALAVHVSTVTLTVIALDRHRCIV-YHLESKISKKISFLIIGLTWAASALLASpLAIFREYSVIEISPdfkiqaCSEKWPN 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 154 YHKHY-----ILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALlktviiVLSVFIACWAPL 228
Cdd:cd15399  160 GTLNDgtiysVSMLLIQYVLPLAIISYAYIRIWTKLKNHVSPGGGNDHYHQRRRKTTKMLVC------VVVVFAVSWLPF 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 347452693 229 FIL-LLLDVGCKV---KTCQILYKAeyFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15399  234 HAFqLASDIDSKVldlKEYKLIYTI--FHVIAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
3-277 5.50e-06

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 47.06  E-value: 5.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTK-KFHRPMYYFIGNLALSDLlagvAYIANLLLSGATT---YKLTPAQWFLREG 78
Cdd:cd15190   12 LIPVIYMLVFVLGLSGNGLVLWTVFRSKrKRRRSADTFIANLALADL----TFVVTLPLWAVYTalgYHWPFGSFLCKLS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  79 SMFVALS--ASVFSLLAIAIERYITMlkmkLHNGSNS-----SRSFLLISACWVISLILgGLPIM---------GWNCIG 142
Cdd:cd15190   88 SYLVFVNmyASVFCLTGLSFDRYLAI----VRSLASAklrsrTSGIVALGVIWLLAALL-ALPALilrttsdleGTNKVI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 143 SLPSCSTVLPLYHKHY------ILFCTTVFTLLLLTIVILYCRIYSLVrTRSRRLTFRKNISKASRssekslaLLKTVII 216
Cdd:cd15190  163 CDMDYSGVVSNESEWAwiaglgLSSTVLGFLLPFLIMLTCYFFIGRTV-ARHFSKLRRKEDKKKRR-------LLKIIIT 234
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 347452693 217 VLSVFIACWAP---------LFILLLLDVGCKVKtcQILYKAE-YFLVLAVLNSGTNPIIYTLTNKEMRRA 277
Cdd:cd15190  235 LVVTFALCWLPfhlvktlyaLMYLGILPFSCGFD--LFLMNAHpYATCLAYVNSCLNPFLYAFFDPRFRQQ 303
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
9-276 5.93e-06

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 47.08  E-value: 5.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   9 ILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDL--LAGVAYIANLLLS------GATTYKLTpaqwflrEGSM 80
Cdd:cd15189    8 FSLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLvfVSGLPFWAMNILNqfnwpfGELLCRVV-------NGVI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 FVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISAC-WVISLILGgLPIMGWNCIGSLP---SCSTVLPLYHK 156
Cdd:cd15189   81 KVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLiWVVGLLLS-IPTFLLRKIKAIPdlnITACVLLYPHE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 157 HYILFCTTVFTL---LLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSekslALlktVIIVLSVFIACWAPLFILLL 233
Cdd:cd15189  160 AWHFAHIVLLNIvgfLLPLLVITFCNYNILQALRTREESTRCEDRNDSKAT----AL---VLAVTLLFLVCWGPYHFFTF 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 347452693 234 LDVGCKVKT---CQ----ILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRR 276
Cdd:cd15189  233 LDFLFDVGVldeCFwehfIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
3-278 6.07e-06

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 47.07  E-value: 6.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLL--AGVAYIA--NLLLSGATTYKLTPAQWFLREG 78
Cdd:cd15093    2 LIPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELfmLGLPFLAasNALRHWPFGSVLCRLVLSVDGI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  79 SMFvalsASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISAC-WVISLILGgLPIMGWNCIGSLPSCSTVLPLYHKH 157
Cdd:cd15093   82 NMF----TSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAvWVASLLVI-LPVVVFAGTRENQDGSSACNMQWPE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 158 -----YILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKslaLLKTVIIVLSVFIACWAPLFILL 232
Cdd:cd15093  157 paaawSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLRAGWQQRKRSERK---VTRMVVMVVVVFVICWLPFYVLQ 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 347452693 233 LLDVGCKVKTCQILYKAEYF-LVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15093  234 LVNVFVQLPETPALVGVYHFvVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
19-278 6.62e-06

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 46.72  E-value: 6.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  19 NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMFVAL-SASVFSLLAIAIE 97
Cdd:cd15054   18 NSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCcSASILNLCVISLD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  98 RYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPI-MGWNCIGSLPSCSTVLPLYHKHYILFCTTVFTLLLLTIVI 175
Cdd:cd15054   98 RYLLIISpLRYKLRMTPPRALALILAAWTLAALASFLPIeLGWHELGHERTLPNLTSGTVEGQCRLLVSLPYALVASCLT 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 176 LYCRIYSLVRTRSRRLtfrkniskasRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCQILykaEYFLVL 255
Cdd:cd15054  178 FFLPSGAICFTYCRIL----------LAARKALKASLTLGILLGMFFVTWLPFFVANVVQAVCDCVSPGLF---DVLTWL 244
                        250       260
                 ....*....|....*....|...
gi 347452693 256 AVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15054  245 GYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
19-284 7.19e-06

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 46.87  E-value: 7.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  19 NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMFVAL-SASVFSLLAIAIE 97
Cdd:cd15307   18 NILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFcTASIMHLCTISVD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  98 RYITM-LKMKLHNGSNSSRSFLLISACWVISLILG-GLPIMGWNCIGSL---PSCSTVLPLYHKHYILFCTTVFTLLLLT 172
Cdd:cd15307   98 RYLSLrYPMRFGRNKTRRRVTLKIVFVWLLSIAMSlPLSLMYSKDHASVlvnGTCQIPDPVYKLVGSIVCFYIPLGVMLL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 173 IVILYCRIYSLVRTRSRRLTfrkniskasRSSEKSLALLKtviIVLSVFIACWAPLFILLLLDVGCKvkTCQILYKAEYF 252
Cdd:cd15307  178 TYCLTVRLLARQRSRHGRII---------RLEQKATKVLG---VVFFTFVILWSPFFVLNLLPTVCA--ECEERISHWVF 243
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 347452693 253 LVLAVL---NSGTNPIIYTLTNKEMRRAFIRIMSC 284
Cdd:cd15307  244 DVVTWLgyaSSMVNPIFYTIFNKVFRQAFKKVLLC 278
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
15-236 8.51e-06

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 46.28  E-value: 8.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  15 IILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVA--YIANLLLSGATTYKLTpaqWFLREGSMFVALSAsVFSLL 92
Cdd:cd15905   12 IIFANLFIILGIACNRKLHNTANYFFLSLLLADLLTGVAlpFIPGMSNESRRGYHSC---LFVYVAPNFLFLSF-LANLL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  93 AIAIERYITMLKMKLHNGSNSSRSF-LLISACWVISLILGGLPIMGWNCIGSLPSCST--VLP---LYHKHYILFCTTVF 166
Cdd:cd15905   88 MVHYERYLCIVYPLQYHNFWVHRWVpLALLLTWALPLLFACLPALGWNNWTPGSNCSYkqVFPaayIYLEVYGLVLPSIL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 167 TLLlltivilyCRIYSLVRTRSRRLtfrKNISKASRSSEK----------SLALLKTVIIVLSVFIACWAPLFILLLLDV 236
Cdd:cd15905  168 AIA--------FMSVRVLAVARRQL---QDICKLLRAVQRdgpseleqqlNLRYAKCIAGVSLTFLVCWVPYIAYLLMSV 236
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
16-100 9.14e-06

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 46.27  E-value: 9.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLlsgatTYKLTPAQWFLREGSMF-------VALSASV 88
Cdd:cd15394   15 VVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTL-----AYAFEPRGWVFGRFMCYfvflmqpVTVYVSV 89
                         90
                 ....*....|..
gi 347452693  89 FSLLAIAIERYI 100
Cdd:cd15394   90 FTLTAIAVDRYY 101
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
6-278 9.75e-06

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 46.40  E-value: 9.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAgvayIANLLLSGATTYKltpAQWFLREGSMFVALS 85
Cdd:cd15092    5 VVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLV----LLTLPFQGTDIFL---GFWPFGNALCKTVIA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  86 -------ASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGgLPIMgwnCIGSLP------SCSTVL 151
Cdd:cd15092   78 idyynmfTSTFTLTAMSVDRYVAICHpIKALDVRTPHKAKVVNVCIWALASVVG-VPVM---VMGSAQvedeeiECLVEI 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 152 PL---YHKHYILFCTTVFTLLLLTIVILYCriYSLVrtrSRRLtfrKNISKASRSSEKSLAL---LKTVIIVLSVFIACW 225
Cdd:cd15092  154 PTpqdYWDPVFGICVFLFSFIIPVLIISVC--YSLM---IRRL---RGVRLLSGSKEKDRNLrriTRLVLVVVAVFVGCW 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 347452693 226 APLFILLLLD-VGCKVKTCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15092  226 TPIQIFVLAQgLGVQPSSETAVAILRFCTALGYVNSSLNPVLYAFLDENFKACF 279
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
6-278 1.01e-05

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 46.50  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLlsgaTTYKLTPAQW-----------F 74
Cdd:cd15204    5 VVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEM----DYYVVRQRSWthgdvlcavvnY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  75 LREGSMFValsaSVFSLLAIAIERYITmLKMKLHNGSNSSRSFLLISACWVISLILgGLPIMGWNCIGSLPS-----CST 149
Cdd:cd15204   81 LRTVSLYV----STNALLVIAIDRYLV-IVHPLKPRMKRRTACVVIALVWVVSLLL-AIPSAVYSKTTPYANqgkifCGQ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 150 VLP----LYHKHYILFcTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKN--ISKASRSSEKSLALLktvIIVLSVFIA 223
Cdd:cd15204  155 IWPvdqqAYYKAYYLF-LFVLEFVLPVLIMTLCYLRIVRKVWFRRVPGQQTeqIRRRLRRRRRKVRLL---VVILTAFVL 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 347452693 224 CWAPLFILLLL-----DVGCKVK-TCQILYKAEyflVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15204  231 CWAPYYGYAIVrdffpTLLSKEKlNTTIFYIVE---ALAMSNSMINTVVYVAFNNNIRKYL 288
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
3-278 1.30e-05

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 46.08  E-value: 1.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDL-LAGVAYIANLLLSGATTYKLTPAQWFLREGSMF 81
Cdd:cd16003    2 LWSLAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDAsMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  82 VALSASVFSLLAIAIERYITM---LKMKLhngsNSSRSFLLISACWVISLILgGLPIMGWNCIGSLPS---CSTVLPLYH 155
Cdd:cd16003   82 TSVFASIYSMTAIAVDRYMAIidpLKPRL----SATATKVVIGSIWILAFLL-AFPQCLYSKTKVMPGrtlCFVAWPGGP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 156 KHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKS-LALLKTVIIVLSVFIACWAPLFILLLL 234
Cdd:cd16003  157 DQHFTYHIIVIVLVYCLPLLVMGITYTIVGITLWGGEIPGDTSDKYHEQLRAkRKVVKMMIIVVLTFAICWLPYHIYFIV 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 347452693 235 DVGC----KVKTCQILYKAEYFlvLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd16003  237 TGLYqqlnRWKYIQQVYLASFW--LAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
1-137 1.38e-05

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 45.91  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   1 IKLTTVVFILicCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSM 80
Cdd:cd15005    2 LKLTTLGLIL--CVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIYGALSCKVIAF 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 FVALSA--SVFSLLAIAIERYITMLKMKLHNGSNSS-RSFLLISACWVISLILGGLPIMG 137
Cdd:cd15005   80 LAVLFCfhSAFTLFCIAVTRYMAIAHHRFYAKRMTFwTCLAVICMAWTLSVAMAFPPVFD 139
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
6-278 1.47e-05

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 46.01  E-value: 1.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYI----ANLLLSGATTYKLTPAQWflrEGSMF 81
Cdd:cd15957    5 IVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVpfgaAHILLKTWTFGNFWCEFW---TSIDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  82 VALSASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPI-MGW---------NCIGSLPSC--- 147
Cdd:cd15957   82 LCVTASIETLCVIAVDRYFAITSpFKYQSLLTKNKARVIILMVWIVSGLTSFLPIqMHWyrathqeaiNCYAEETCCdff 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 148 --------STVLPLYHKHYILfcttvftlllltiVILYCRIYSLVRTRSRRL-----------------TFRKNISKASR 202
Cdd:cd15957  162 tnqayaiaSSIVSFYVPLVIM-------------VFVYSRVFQEAKRQLQKIdksegrfhnqnidqngsGGGGGNRRRSK 228
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 347452693 203 SSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVktcqILYKAEYFLV--LAVLNSGTNPIIYTlTNKEMRRAF 278
Cdd:cd15957  229 FCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDN----LIRKEVYILLnwIGYVNSGFNPLIYC-RSPDFRIAF 301
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
6-45 1.71e-05

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 45.35  E-value: 1.71e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLAL 45
Cdd:cd15224    5 LLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSF 44
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
9-275 1.83e-05

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 45.56  E-value: 1.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   9 ILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDL--LAGVAYIANLLlSGATTYKLTPAQWFLREGSMFVALSA 86
Cdd:cd15380    8 IAICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLvfVLGLPFWAENI-RNQFNWPFGNFLCRVISGVIKANLFI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  87 SVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLP-----SCSTVLPLYHKHYI-L 160
Cdd:cd15380   87 SIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHVPdlnisACILLFPHEAWHFArR 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 161 FCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLktviiVLSVFIACWAPLFILLLLDVGCKV 240
Cdd:cd15380  167 VELNIVGFLLPLAAIVFFNFHIIASLRERTEESRKRCGGLKDTKATRLILT-----LVLMFLVCWTPYHFFAFLDFLFQV 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 347452693 241 KTCQILYkAEYFL--------VLAVLNSGTNPIIYTLTNKEMR 275
Cdd:cd15380  242 EVIQGCF-WEEFIdlglqlanFFAFANSCLNPVIYVFAGKLFR 283
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
19-276 2.09e-05

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 45.20  E-value: 2.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  19 NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLA---GVAYIANLLLSGATTYKLTPAQWFLREGSMFVALSasVFSLLAIA 95
Cdd:cd15078   18 NLLVLILYYKFKRLRTPTNLLLVNISLSDLLVsllGVTFTFMSCVRGRWVFDVAGCVWDGFSNSLFGIVS--IMTLTVLA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  96 IERYITMLKMKLHNGSNSSRSfllISACWVISLILGGLPIMGWN----------CIGSLPSCSTVLPLYHKHYILFCttv 165
Cdd:cd15078   96 YERYIRVVHAKVVNFSWSWRA---ITYIWLYSLAWTGAPLLGWNrytlevhglgCSFDWKSKDPNDTSFVLLFFLGC--- 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 166 ftLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCQI 245
Cdd:cd15078  170 --LVVPLGIMAYCYGHILYEIRMLRSVEDLQTFQVIKILKYEKKVAKMCLLMISTFLICWMPYAVVSLLVTSGYSKLVTP 247
                        250       260       270
                 ....*....|....*....|....*....|.
gi 347452693 246 LYKAEYFLvLAVLNSGTNPIIYTLTNKEMRR 276
Cdd:cd15078  248 TIAIIPSL-FAKSSTAYNPVIYIFMIRKFRQ 277
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
3-278 3.67e-05

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 44.56  E-value: 3.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMY-YFIGNLALSDLLagvayIANLLLSGATTYKLTPAQWFLREGSMF 81
Cdd:cd15319    2 VTGCLLSLLILWTLLGNILVCAAVVRFRHLRSKVTnIFIVSLAVSDLF-----VALLVMPWKAVAEVAGYWPFGAFCDVW 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  82 VAL-----SASVFSLLAIAIERYITMLKMKLHNGSNSSR-SFLLISACWVISLILGGLPI-MGW-------------NCI 141
Cdd:cd15319   77 VAFdimcsTASILNLCVISVDRYWAISSPFRYERKMTQRvALVMISVAWTLSVLISFIPVqLNWhkdsgddwvglhnSSI 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 142 GSLPSCSTVLPLYHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSS----------------- 204
Cdd:cd15319  157 SRQVEENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQIQIRRISSLERAAEHAQSCrsnridchhhtslrtsi 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 205 EKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKT--------CQILYKAEYFLVLAVLNSGTNPIIYTLtNKEMRR 276
Cdd:cd15319  237 KKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCDRPPadpdaglpCVSETTFDVFVWFGWANSSLNPIIYAF-NADFRK 315

                 ..
gi 347452693 277 AF 278
Cdd:cd15319  316 VF 317
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
5-277 5.08e-05

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 44.02  E-value: 5.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAgvayianLLLSGATTYKL-TPAQWFLRE----GS 79
Cdd:cd15928    4 TAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLI-------FLVLPLDLYRLwRYRPWRFGDllcrLM 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  80 MFVALS---ASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGG--LPIMGWNCI-GSLPSCSTVLP 152
Cdd:cd15928   77 YFFSETctyASILHITALSVERYLAICHpLRAKVLVTRGRVKLLIAVIWAVAIVSAGpaLVLVGVEHIqGQQTPRGFECT 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 153 LYHKHYILFCTTVFTLLLLTIVILYCR--IYSLVrtrSRRLTFRKNISKASRSSEKSLALLKTV----IIVLsVFIACWA 226
Cdd:cd15928  157 VVNVSSGLLSVMLWVSTSFFFVPMVCLslLYGLI---GRALWDRRQRSRTAGASRRDNNHRQTVrmlaVIVL-AFVLCWL 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 347452693 227 PLFILLLLDVGCKVKTCQILYKAEYF----LVLAVLNSGTNPIIYTLTNKEMRRA 277
Cdd:cd15928  233 PFHVGRVIFNHSRASTKHLHYVSQYFnlvsFVLFYLSAAINPILYNLMSKRYRYA 287
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
9-267 5.82e-05

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 43.97  E-value: 5.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   9 ILICCCIILE---NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTykltpaQWF--------LRE 77
Cdd:cd15384    5 VVLAVMFVISfigNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTV------AWLagntmcklVKY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  78 GSMFvALSASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLIsaCWVISLIL------------GGLPIMGWNCIGS- 143
Cdd:cd15384   79 LQVF-GLYLSTYITVLISLDRCVAILYpMKRNQAPERVRRMVTV--AWILSPIFsipqavifhverGPFVEDFHQCVTYg 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 144 ---------LPSCSTVLPLYHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSekslalLKTV 214
Cdd:cd15384  156 fytaewqeqLYNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSRDFQGLEIYTRNRGPNRQRLFHKAKVKS------LRMS 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 347452693 215 IIVLSVFIACWAPLFILLLLDVGCKVKTC-QILYKAEYFlvLAVLNSGTNPIIY 267
Cdd:cd15384  230 AVIVTAFILCWTPYYVIMIWFLFFNPYPLnDILFDVIFF--FGMSNSCVNPLIY 281
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
1-278 6.39e-05

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 43.92  E-value: 6.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   1 IKLTTVVFILIccciILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTykltpaQWFLREGS- 79
Cdd:cd15208    4 IALYILVFIVG----LVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTE------TWFFGQVLc 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  80 ------MFVALSASVFSLLAIAIERYITM---LKMKlhngSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLP----- 145
Cdd:cd15208   74 kiipylQTVSVSVSVLTLSCIALDRWYAIchpLMFK----STAKRARVSILIIWIVSLLIMIPQAIVMECSRVVPlankt 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 146 ----------SCSTVLPLYHK-----HYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLAL 210
Cdd:cd15208  150 illtvcderwSDSIYQKVYHIcfflvTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVVQRKWNKPRKSAVAAEEKQLRSR 229
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 347452693 211 LKT---VIIVLSVFIACWAPLFILLLLDVGCKVKTCQILYKAEYFLV---LAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15208  230 RKTakmLIVVVIMFAICYLPVHLLNILRYVFGLFTVDRETIYAWFLFshwLVYANSAINPIIYNFMSGKFREEF 303
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
7-227 7.73e-05

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 43.72  E-value: 7.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFILICCCIilENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAgvayIANLLLSGATTYKLTPA--QWFLREGSMFVAL 84
Cdd:cd15079    8 IFLGIVSLL--GNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLM----MIKMPIFIYNSFYEGWAlgPLGCQIYAFLGSL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  85 S--ASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIM-GWNCI---GSLPSCST--------- 149
Cdd:cd15079   82 SgiGSIWTNAAIAYDRYNVIVKPLNGNPLTRGKALLLILFIWLYALPWALLPLLfGWGRYvpeGFLTSCSFdyltrdwnt 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 150 ------------VLPLYhkhYILFCttvftlllltivilYCRIYSLVRTRSRRLT----------FRKNISKASRSSEKS 207
Cdd:cd15079  162 rsfvatifvfayVIPLI---IIIYC--------------YSFIVKAVFAHEKALReqakkmnvvsLRSNADANKQSAEIR 224
                        250       260
                 ....*....|....*....|
gi 347452693 208 LAllKTVIIVLSVFIACWAP 227
Cdd:cd15079  225 IA--KVALTNVFLWFIAWTP 242
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
6-137 9.85e-05

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 43.37  E-value: 9.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYI----ANLLLSGAT-TYKLTPAQWFLregSM 80
Cdd:cd15431    5 VLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVpqmlVNCLSDRPTiSYSRCLAQMYI---SL 81
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 347452693  81 FVALSASVfsLLAI-AIERYIT-------MLKMklhngsNSSRSFLLISACWVISLILGGLPIMG 137
Cdd:cd15431   82 FLGITECL--LLAVmAYDRFVAicnplryTLIM------SWRVCIQLAAGSWVSAFLLTVIPVLT 138
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
6-129 1.51e-04

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 42.63  E-value: 1.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGAT-----TYKLTPAQWFLregsM 80
Cdd:cd15232    5 WLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTerktiSFGGCMAQLYF----F 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 347452693  81 FVALSASVFSLLAIAIERYITMLKmKLHNGSNSSRSF--LLISACWVISLI 129
Cdd:cd15232   81 TWSLGSELLLLTAMAYDRYVAICH-PLHYSTIMRKEVcvGLATGVWAIGML 130
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
178-278 1.59e-04

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 42.48  E-value: 1.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 178 CRIYSLVRTRSRRLTFRKNISKASRSSEKslaLLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCQILYKAEYFLV-LA 256
Cdd:cd15972  181 CYLLIVVKVRSSGRRVRATSTKRRGSERK---VTRMVVIVVAAFVLCWLPFYALNIVNLVCPLPEEPSLFGLYFFVVvLS 257
                         90       100
                 ....*....|....*....|..
gi 347452693 257 VLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15972  258 YANSCANPIIYGFLSDNFKQGF 279
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
6-100 1.68e-04

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 42.68  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDL-----LAGVAyIANLLLSGAT-TYKLTPAQWFLreGS 79
Cdd:cd15419    5 LLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLcyssvIAPKA-LANFLSESKTiSYNGCAAQFFF--FS 81
                         90       100
                 ....*....|....*....|.
gi 347452693  80 MFVALSAsvFSLLAIAIERYI 100
Cdd:cd15419   82 LFGTTEG--FLLAAMAYDRFI 100
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
6-131 1.75e-04

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 42.26  E-value: 1.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTP-----AQWFLregsm 80
Cdd:cd15237    5 ILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISfvgcaAQMFF----- 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 347452693  81 FVALSASVFSLLAI-AIERYITMLKmKLHNGSNSSRS--FLLISACWVISLILG 131
Cdd:cd15237   80 FLALGVTECVLLAVmAYDRYVAICN-PLRYSVIMSRRvcVRLAATSWASGFLNS 132
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
16-100 2.02e-04

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 42.40  E-value: 2.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLL-----SGATTYKLTPAQWFLREGsmFVALSASVfs 90
Cdd:cd15950   15 LLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSifwlgSAEISFEACFTQMFFVHS--FTAVESGV-- 90
                         90
                 ....*....|
gi 347452693  91 LLAIAIERYI 100
Cdd:cd15950   91 LLAMAFDRYV 100
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
6-147 2.18e-04

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 42.03  E-value: 2.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLL-----SGATTYKLTPAQwflregsM 80
Cdd:cd15424    5 VVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAhllagNGAISFARCTTQ-------M 77
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 347452693  81 FVALS-ASVFSLL--AIAIERYITMLKMKLHNGS-NSSRSFLLISACWVISLILGglpIMGWNCIGSLPSC 147
Cdd:cd15424   78 YIALSlGSTECLLlgAMAYDRYLAICHPLLYAAAmGRWRQLQLALSCWAIGFLLS---VINVGCTLRHPFC 145
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
42-277 2.35e-04

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 41.97  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  42 NLALSDLLAGVAYIANLLLSGATTYKLTpAQWFLREGSMFVAL--SASVFSLLAIAIERYITMLKMKlhNGSNSSRSFLL 119
Cdd:cd15213   41 NLAFSDIMLSLVCMPFAAVTIITGRWIF-GDIFCRISAMLYWFfvLEGVAILLIISVDRYLIIVQRQ--DKLNPHRAKIL 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 120 ISACWVISLILGGLPIMGWNCIG---SLPSCS---TVLPLYHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRltf 193
Cdd:cd15213  118 IAVSWVLSFCVSFPPLVGWGKYEfppRAPQCVlgyTESPADRIYVVLLLVAVFFIPFLIMLYSYFCILNTVRSFKTR--- 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 194 rkniskasrssekslaLLKTVIIVLSVFIACWAPLFILLLL-------DVGCKVKTCqilykaeyFLVLAVLNSGTNPII 266
Cdd:cd15213  195 ----------------AFTTILILFIGFSVCWLPYTVYSLLsvfsrysSSFYVISTC--------LLWLSYLKSAFNPVI 250
                        250
                 ....*....|.
gi 347452693 267 YTLTNKEMRRA 277
Cdd:cd15213  251 YCWRIKKFREA 261
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
6-124 2.38e-04

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 42.17  E-value: 2.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLS-----GATTYKLTPAQWFLregsM 80
Cdd:cd15938    5 ALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDflsqrKAISYEACIAQLFF----L 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 347452693  81 FVALSASVFSLLAIAIERYITMLKmKLHNGSNSSRSF--LLISACW 124
Cdd:cd15938   81 HFVGAAEMFLLTVMAYDRYVAICK-PLHYTTIMSRRLcwVLVAASW 125
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
6-278 2.47e-04

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 41.88  E-value: 2.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDllagvayIANLLLSGATTYKLTP-AQWFLreGS----- 79
Cdd:cd15095    5 LIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTD-------LAFLVCCVPFTAALYAtPSWVF--GDfmckf 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  80 ----MFVALSASVFSLLAIAIERY--ITMLKMKLHNgsNSSRSFLLISAC-WVISLILgGLPIM------GWNCIGSLPS 146
Cdd:cd15095   76 vnymMQVTVQATCLTLTALSVDRYyaIVHPIRSLRF--RTPRVAVVVSACiWIVSFLL-SIPVAiyyrleEGYWYGPQTY 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 147 CSTVLP--LYHKHYILFCTTVFTLLLLTIVilyCRIYSLVRTRSRRLTFRKNISKASRsSEKSLA----LLKTVIIVLSV 220
Cdd:cd15095  153 CREVWPskAFQKAYMIYTVLLTYVIPLAII---AVCYGLILRRLWRRSVDGNNQSEQL-SERALRqkrkVTRMVIVVVVL 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 221 FIACWAPLFILLLL-DVGCKVKTCQILYKAEYF-LVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15095  229 FAICWLPNHVLNLWqRFDPNFPETYATYALKIAaLCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
6-100 2.47e-04

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 42.02  E-value: 2.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYK-LTPAQWFLREGSMFVAL 84
Cdd:cd15415    5 MLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKtISYSACIAQHFFFAVFV 84
                         90
                 ....*....|....*.
gi 347452693  85 SASVFSLLAIAIERYI 100
Cdd:cd15415   85 TTEGFLLAVMAYDRYV 100
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
6-130 2.55e-04

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 42.09  E-value: 2.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLL---LSGATTYKLTP--AQWFLregsm 80
Cdd:cd15912    5 LLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLanlLSGKKTISFAGcfAQSFF----- 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 347452693  81 FVALSASVFSLLAI-AIERYITMLKmKLHNGS--NSSRSFLLISACWVISLIL 130
Cdd:cd15912   80 YFFLGTTEFFLLAVmSFDRYVAICN-PLHYPTimNSRVCLQLVLGSWVGGFLL 131
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
6-233 2.73e-04

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 41.87  E-value: 2.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLL--------AGVAYIANLLLSGATTYKLTPaqwFLRE 77
Cdd:cd15927    5 ILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLllltcvpfTSTIYTLDSWPFGEFLCKLSE---FLKD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  78 GSMFValsaSVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCI-------GSLPSCS- 148
Cdd:cd15927   82 TSIGV----SVFTLTALSADRYFAIVNpMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVtftltdnQTIQICYp 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 149 ---TVLPLYHKHYILFCTTVFTLL-LLTIVILYCRIYSLVRTRSRRLTFRKNISkASRSSEKSLALLKTVIIVLSVFIAC 224
Cdd:cd15927  158 ypqELGPNYPKIMVLLRFLVYYLIpLLIIGVFYVLMARHLIRSTRNIGSGQNQA-AQRQIEARKKVAKTVLAFVVLFAVC 236

                 ....*....
gi 347452693 225 WAPLFILLL 233
Cdd:cd15927  237 WLPRHVFML 245
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
6-276 2.80e-04

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 42.05  E-value: 2.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvaYIANLLLSGATTYKltPAQWFLREG-----SM 80
Cdd:cd15193    5 ILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLV----FVLTLPFWAASTAL--GGQWLFGEGlcklsSF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 FVALS--ASVFSLLAIAIERYITMLKMkLHNGSNSSRSFLLISAC--WVISLILGGLP------IMGWNCIGSLPS---- 146
Cdd:cd15193   79 IIAVNrcSSILFLTGMSVDRYLAVVKL-LDSRPLRTRRCALITCCiiWAVSLVLGIPSlvyrnlINESVCVEDSSSrffq 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 147 --------CSTVLPLYhkhYILFCttvftlllltivilYCRIYslvrtrsRRLtfRKNISKASRSSEKSLALLKTVIIVL 218
Cdd:cd15193  158 gislatlfLTFVLPLI---VILFC--------------YCSIL-------VRL--RRHFHGAKRTGRRRRNSLRIVFAIV 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 347452693 219 SVFIACWAPL----FILLLLDVGCKVKTCQILYKAEYFLV----LAVLNSGTNPIIYTLTNKEMRR 276
Cdd:cd15193  212 TAFVLSWLPFntlkAVRLLLELGGGVLPCHTTVAIRQGLTitacLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
19-100 3.23e-04

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 41.51  E-value: 3.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  19 NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLS---GATTYKLTP--AQWFLREgsMFVALSASVfsLLA 93
Cdd:cd15223   18 NSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIfwfDANTISLPGcfAQMFFIH--FFTAMESSI--LLV 93

                 ....*..
gi 347452693  94 IAIERYI 100
Cdd:cd15223   94 MALDRYV 100
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
5-278 3.27e-04

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 41.75  E-value: 3.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   5 TVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYK--LTPAQWFLREGSMFV 82
Cdd:cd15133    4 CLTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYELWQNYPflLGSGGCYFKTFLFET 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  83 ALSASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLI-------LGGLPIMGWNCIGSLpSCSTVLPLY 154
Cdd:cd15133   84 VCLASILNVTALSVERYIAVVHpLAARTCSTRPRVTRVLGCVWGVSMLcalpntsLHGIKFLGSGVPASA-QCTVRKPQA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 155 HKHYIL-FCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLA-------LLKTVIIVLSVFIACWA 226
Cdd:cd15133  163 IYNMIPqHTGHLFFVLPMAVISVLYLLMALRLARERGLDATGAGSKIGTRTGQLLQhprtraqVTKMLFILVVVFAICWA 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 347452693 227 PLFI--LLLLDVGCKVKTCQILYKAEYFL--VLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15133  243 PFHIdrLMWSFISDWTDNLHEVFQYVHIIsgVFFYLSSAVNPILYNLMSTRFREMF 298
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
6-277 3.36e-04

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 41.71  E-value: 3.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAyianLLLSGATTYKLTPAQWFLREGSMF-VAL 84
Cdd:cd15920    5 VMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLC----LPFRVAYQNTAGPLSFCKIVGAFFyLNM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  85 SASVFSLLAIAIERYITMLK----MKLHNGSNSSRSFLLIsacWVIsLILGGLPIMGWNciGSLPSCSTVLPLYHKHYIL 160
Cdd:cd15920   81 YASILFLSLISLDRYLKIIKplqqFKIHTVPWSSAASGGV---WLL-LLACMIPFLFES--RNEGPCDNKCFHFRSKGLT 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 161 FCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTvIIVLSVFIACWAPL------FILLLL 234
Cdd:cd15920  155 AGGINLTAVVIFYILSLLFLYFYAKISHKLYKVSLGNAQQQIKKASKRAIIKT-FIVLAIFIVCFVPYhivrvpYVLAQI 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 347452693 235 DVGCKVKTCQILYKA-EYFLVLAVLNSGTNPIIYTLTNKEMRRA 277
Cdd:cd15920  234 DVISSLPWKQTLHIAnELVLCLSALNSCLDPIIYFFLSSSFRRA 277
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
6-149 4.01e-04

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 41.58  E-value: 4.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVA----YIANLLL-SGATTYKLTPAQWFlregsm 80
Cdd:cd15943   19 AVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAitpkMLVNFLAeNKTISFTGCAAQMY------ 92
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 347452693  81 FVALSASV--FSLLAIAIERYITMLKMKLHNGSNSSR-SFLLISACWVISLILGGLPImgwNCIGSLPSCST 149
Cdd:cd15943   93 FFVAFATTecFLLAVMAYDRYVAICNPLLYTVIMSPRvCIQLVAGSYLIGFVNALIQT---ICTFRLPFCGS 161
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
7-48 4.55e-04

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 41.33  E-value: 4.55e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 347452693   7 VFILICC---CIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDL 48
Cdd:cd15222    3 ISIPFCLlylVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDL 47
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
3-278 4.61e-04

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 41.37  E-value: 4.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDL-LAGVAYIANLLLSGATTYKLTPAQWFLREGSMF 81
Cdd:cd16004    2 LWAIAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLsMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  82 VALSASVFSLLAIAIERYITM---LKMKLHNGSNSsrsfLLISACWVISLILgGLPIMGWNCI---GSLPSCSTVLP--L 153
Cdd:cd16004   82 TAMFVSIYSMTAIAADRYMAIihpFKPRLSAGSTK----VVIAGIWLVALAL-AFPQCFYSTVtmdQGRTKCIVAWPgdS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 154 YHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTR--SRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFIL 231
Cdd:cd16004  157 GGKHQLTYHLAVIVLIYLLPLAVMFVTYSIIGITlwRSAVPGHQAHGAYHRQLQAKKKFVKTMVVVVVTFAICWLPYHLY 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 347452693 232 LLL-----DVGCKvKTCQILYKAEYFlvLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd16004  237 FILgsfneDIYCQ-KYIQQVYLAIFW--LAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
7-278 4.75e-04

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 41.34  E-value: 4.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFILICCCIILENIFVLLTIWKTKKFHRPMYY---FIGNLALSDLL--AGVAYIANLLLS------GATTYKLTPAqwfL 75
Cdd:cd15338    6 VFGVICFLGIIGNSIVIYTIVKKSKFRCQQTVpdiFIFNLSIVDLLflLGMPFLIHQLLGngvwhfGETMCTLITA---L 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  76 REGSMFValsaSVFSLLAIAIERYI-TMLKMKLHNGSNSSRSFLLISACWVISLiLGGLPIMGWNCIGSLPS----CSTV 150
Cdd:cd15338   83 DTNSQIT----STYILTVMTLDRYLaTVHPIRSTKIRTPRVAVAVICLVWILSL-LSITPVWMYAGLMPLPDgsvgCALL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 151 LPLYHKHYILFCTTVFTLLLLTIVILYCRIYslvrtrsrRLTFRKNISKASRSSEKSLAL-----LKTVIIVLSVFIACW 225
Cdd:cd15338  158 LPNPETDTYWFTLYQFFLAFALPLVVICVVY--------FKILQNMASTVAPLPQRSLRVrtkkvTRMAVAICLAFFICW 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 347452693 226 APLFILLLLDVGCKVKTCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15338  230 APFYILQLAHLSIDRPSLAFLYAYNVAISMGYANSCINPFLYIMLSETFKRQF 282
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
6-278 4.94e-04

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 41.43  E-value: 4.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLlTIWKTKKFHRPMYYFIGNLALSDLLAgVAYIANLLLSGATTYKLTPAQWFLREGSMFVALS 85
Cdd:PHA02834  33 VFYILLFIFGLIGNVLVI-AVLIVKRFMFVVDVYLFNIAMSDLML-VFSFPFIIHNDLNEWIFGEFMCKLVLGVYFVGFF 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  86 ASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGSLPSCSTVLPLYHKHYIL----- 160
Cdd:PHA02834 111 SNMFFVTLISIDRYILVVNATKIKNKSISLSVLLSVAAWVCSVILSMPAMVLYYVDNTDNLKQCIFNDYHENFSWsaffn 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 161 FCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKniskasrsseKSLALLKTVIIVLSVFiacWAPLFILL-------- 232
Cdd:PHA02834 191 FEINIFGIVIPLIILIYCYSKILYTLKNCKNKNKT----------RSIKIILTVVTFTVVF---WVPFNIVLfinslqsv 257
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 347452693 233 -LLDVGCkVKTCQILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:PHA02834 258 gLIDIGC-YHFKKIVYSIDIAELISFVHCCVNPIIYAFVGKNFKKVF 303
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
16-275 5.39e-04

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 40.99  E-value: 5.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayianLLLSGATTYKLTPAQWFLREGSMFVALSA--------- 86
Cdd:cd15085   15 IFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLM--------MALCGTTIVTVTNYEGYFYLGDAFCIFQGfavnyfgiv 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  87 SVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCIGS---LPSCSTVLP--LYHKHYILF 161
Cdd:cd15085   87 SLWSLTLLAYERYNVVCKPMGGLKLSTKRGYQGLLFIWLFCLFWAVAPLFGWSSYGPegvQTSCSIGWEerSWSNYSYLI 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 162 CTTVFTLLLLTIVILYCriYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVK 241
Cdd:cd15085  167 LYFLMCFVIPVAIIGFS--YGNVLRSLHKLNKKIEQQGGKNCPEEEERAVIMVLAMVIAFLICWLPYTVFALIVVVNPEL 244
                        250       260       270
                 ....*....|....*....|....*....|....
gi 347452693 242 TCQILyKAEYFLVLAVLNSGTNPIIYTLTNKEMR 275
Cdd:cd15085  245 SISPL-AATMPTYFAKTSPVYNPIIYIFLNKQFR 277
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
1-278 6.34e-04

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 40.57  E-value: 6.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   1 IKLTTVVFILICCciilENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVA-----YIANLLlsgaTTYKLTPAQWFL 75
Cdd:cd15979    4 ILLYSVIFLLSVF----GNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFcmpftLIPNLM----GTFIFGEVICKA 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  76 REGSMFVALSASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVISLILgGLPIMGWNCIGSLP--------S 146
Cdd:cd15979   76 VAYLMGVSVSVSTFSLVAIAIERYSAICNpLQSRVWQTRSHAYRVIAATWLLSGLI-MIPYPVYSVTVPVPvgdrprghQ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 147 CSTVLPLYHKH---YILFCTTVFTLLLLTIVILYCRIyslvrtrSRRLtFRKNISKASrssekslaLLKTVIIVLSVFIA 223
Cdd:cd15979  155 CRHAWPSAQVRqawYVLLLLILFFIPGVVMIVAYGLI-------SREL-YRGLLAKKR--------VIRMLVVIVAMFFL 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 347452693 224 CWAPLFILLLLDVGCKVKTCQILYKA--EYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15979  219 CWLPIFSANTWRAFDPLSAHRALSGApiSFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
1-278 6.69e-04

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 40.84  E-value: 6.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   1 IKLTTVVFILICCCiileNIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagVAYIaNLLLSGATTYKLtpaQWFLREGS- 79
Cdd:cd15195    4 VLVTWVLFVISAAG----NLTVLIQLFRRRRAKSHIQILIMHLALADLM--VTFF-NMPMDAVWNYTV---EWLAGDLMc 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  80 ---MFV---ALSASVFSLLAIAIERYITMLKMKLHNGSNsSRSFLLISACWVISLILgGLP--------------IMGWN 139
Cdd:cd15195   74 rvmMFLkqfGMYLSSFMLVVIALDRVFAILSPLSANQAR-KRVKIMLTVAWVLSALC-SIPqsfifsvlrkmpeqPGFHQ 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 140 CI--GSLPS-------------CSTVLPLYhkhYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRrltfRKNISKAsrss 204
Cdd:cd15195  152 CVdfGSAPTkkqerlyyfftmiLSFVIPLI---ITVTCYLLILFEISKMAKRARDTPISNRRRSR----TNSLERA---- 220
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 347452693 205 eKSLALLKTVIIVLSvFIACWAPLFILLLLDVGCKVKTCQILYKAE-YFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15195  221 -RMRTLRMTALIVLT-FIVCWGPYYVLGLWYWFDKESIKNLPPALShIMFLLGYLNPCLHPIIYGVFMKEIRNWI 293
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
6-129 7.67e-04

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 40.26  E-value: 7.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDL-LAGVA---YIANLLLSGAT-TYKLTPAQWFLregSM 80
Cdd:cd15226    5 VFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLcLSSFAtpkMICDLLREHKTiSFGGCMAQIFF---LH 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 347452693  81 FVAlSASVFSLLAIAIERYITMLKmKLHNGSNSSRS--FLLISACWVISLI 129
Cdd:cd15226   82 FFG-GSEMVLLIAMAFDRYVAICK-PLHYLTIMSPRmcILLVVASWIIGFI 130
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
16-100 9.16e-04

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 40.35  E-value: 9.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLL-----LSGATTYKLTPAQWFLREgsMFVALSASVfs 90
Cdd:cd15917   15 LLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLgifwfNAREISFDACLAQMFFIH--SFTAMESGV-- 90
                         90
                 ....*....|
gi 347452693  91 LLAIAIERYI 100
Cdd:cd15917   91 LLAMAFDRYV 100
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
7-278 9.30e-04

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 40.22  E-value: 9.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAyiANLLLSGATTYKLTPAQWFLRE--GSMFVAL 84
Cdd:cd15973    6 IYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLS--VPFLAASAALQHWPFGSAMCRTvlSVDGINM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  85 SASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISAC-WVISLILGgLPIMGW-------------NCIGSLPSCSTV 150
Cdd:cd15973   84 FTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICvWILSLLVI-SPIIIFadtatrkgqavacNLIWPHPAWSAA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 151 LPLYhkhyilfcttVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKslaLLKTVIIVLSVFIACWAPLFI 230
Cdd:cd15973  163 FVIY----------TFLLGFLLPVLAIGLCYILIIGKMRAVALKAGWQQRRKSEKK---ITRMVLMVVTVFVICWMPFYV 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 347452693 231 LLLLDVGCKVKTCQILYKAeyfLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15973  230 VQLLNLFLPRLDATVNHAS---LILSYANSCANPILYGFLSDNFRRSF 274
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
2-278 1.02e-03

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 40.17  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   2 KLTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvaYIANL-LLSGATTYKLTPAQWFLREGSM 80
Cdd:cd15974    1 VLIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADEL----FMLGLpFLATQNAISYWPFGSFLCRLVM 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 F---VALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISA-CWVISLILGGLPIMGWNCIGSLPSCSTVLP---- 152
Cdd:cd15974   77 TvdgVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINAtVWTLSFLVVLPVIIFSDVQPDLNTCNISWPepvs 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 153 LYHKHYILFCTTVFTLLLLTIVilyCRIYSLVRTRSRRLTFRKNISKASRSSEKslaLLKTVIIVLSVFIACWAPLFILL 232
Cdd:cd15974  157 VWSTAFIIYTAVLGFFGPLLVI---CLCYLLIVIKVKSSGLRVGSTKRRKSERK---VTRMVVIIVVVFVFCWLPFYMLN 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 347452693 233 LLDVGCKVKTCQILYKAEYFLV-LAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15974  231 IVNLIVILPEEPAFVGVYFFVVvLSYANSCANPILYGFLSDNFKQSF 277
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
6-70 1.23e-03

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 40.11  E-value: 1.23e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTP 70
Cdd:cd15945   18 LVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIP 82
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
7-48 1.40e-03

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 39.74  E-value: 1.40e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 347452693   7 VFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDL 48
Cdd:cd15916    6 IFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDM 47
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
3-275 1.41e-03

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 39.89  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREG-SMF 81
Cdd:cd15081   14 LTSVWMIFVVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGfTVS 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  82 VALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCI---GSLPSCSTVL------P 152
Cdd:cd15081   94 VCGITGLWSLTIISWERWVVVCKPFGNIKFDGKLAIVGIIFSWVWSAVWCAPPIFGWSRYwphGLKTSCGPDVfsgssdP 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 153 LYHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRrltfRKNISKASRSSEKSLAllKTVIIVLSVFIACWAPLFILL 232
Cdd:cd15081  174 GVQSYMIVLMITCCIIPLAIIILCYLQVWLAIRAVAQ----QQKESESTQKAEKEVS--RMVVVMIFAYCFCWGPYTFFA 247
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 347452693 233 LLDVGCKVKTCQILYKA--EYFLVLAVLnsgTNPIIYTLTNKEMR 275
Cdd:cd15081  248 CFAAANPGYAFHPLAAAlpAYFAKSATI---YNPIIYVFMNRQFR 289
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
6-129 1.54e-03

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 39.71  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANL---LLSG--ATTYKLTPAQWFLregsm 80
Cdd:cd15407    5 IIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVmagLLTGdkVISYNACAAQMFF----- 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 347452693  81 FVA-LSASVFSLLAIAIERYITMLKmKLHNGSNSSRSF--LLISACWVISLI 129
Cdd:cd15407   80 FVVfATVENFLLASMAYDRHAAVCK-PLHYTTTMTTKVcaCLTIGCYVCGFL 130
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
6-48 1.99e-03

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 39.03  E-value: 1.99e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDL 48
Cdd:cd15230    5 VLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDI 47
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
16-276 2.12e-03

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 39.12  E-value: 2.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGV--AYIANLLLSGATTYKLTPAQWFLREG----SMFVALSA--S 87
Cdd:cd15964   15 ILGNVFVLLILLTSHYKLTVPRFLMCNLAFADFCMGIylLLIASVDLHTRSEYYNHAIDWQTGPGcntaGFFTVFASelS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  88 VFSLLAIAIER-YITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGwncIGSLPSCSTVLPL-----YHKHYILF 161
Cdd:cd15964   95 VYTLTVITLERwYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVG---VSSYAKVSICLPMdtetpLAQAYIVF 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 162 CTTVFTLLLLTIVILYCRIYSLVRtrsrrltfrkniSKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCK-- 239
Cdd:cd15964  172 VLMLNIIAFVIICACYIKIYITVR------------NPQYKSGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKpl 239
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 347452693 240 --VKTCQILykaeyFLVLAVLNSGTNPIIYTLTNKEMRR 276
Cdd:cd15964  240 itVSNSKIL-----LVLFYPLNSCANPFLYAIFTKAFRR 273
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
40-278 2.28e-03

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 38.93  E-value: 2.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  40 IGNLALSDLLagvaYIANLLLSGATTYKLT--PAQWFLREGSMF---VALSASVFSLLAIAIERYITMLKMKLHNGSNSS 114
Cdd:cd15002   40 ILNLSAADLL----LLLFSVPFRAAAYSKGswPLGWFVCKTADWfghACMAAKSFTIAVLAKACYMYVVNPTKQVTIKQR 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 115 RSFLLISACWVISLilgGLPIMGW------------NCIGSLPSCS-TVLPLYHKHYILFcttVFTLLLLTIVILYCRIY 181
Cdd:cd15002  116 RITAVVASIWVPAC---LLPLPQWlfrtvkqsegvyLCILCIPPLAhEFMSAFVKLYPLF---VFCLPLTFALFYFWRAY 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 182 SLVRTRSRRltfrkniSKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLdVGCKVKTCQILYKAEYFL--VLAVLN 259
Cdd:cd15002  190 GQCQRRGTK-------TQNLRNQIRSRKLTHMLLSVVLAFTILWLPEWVAWLW-LIHIKSSGSSPPQLFNVLaqLLAFSI 261
                        250
                 ....*....|....*....
gi 347452693 260 SGTNPIIYTLTNKEMRRAF 278
Cdd:cd15002  262 SSVNPIIFLLMSEEFREGF 280
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
181-278 2.43e-03

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 39.00  E-value: 2.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 181 YSLVRTRSRRlTFRKNISKASRSSEKSLALLktVIIVLSVFIACWAPLFILLLLDVGCKVKTCQILYKAEYFLVLAVL-- 258
Cdd:cd15094  185 YTLVILRLRT-VGPKNKSKEKRRSHRKVTRL--VLTVISVYIICWLPYWAFQVHLIFLPPGTDMPKWEILMFLLLTVLsy 261
                         90       100
                 ....*....|....*....|.
gi 347452693 259 -NSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15094  262 aNSMVNPLLYAFLSENFRKSF 282
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
17-271 2.61e-03

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 38.98  E-value: 2.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  17 LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVayianLLLSGATTYKLTPAQWF------LREGSMFVALS-ASVF 89
Cdd:cd15212   16 LGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTAL-----LCLPFAFLTLFSRPGWLfgdrlcLANGFFNACFGiVSTL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  90 SLLAIAIERYITMLKMKLHNGSnSSRSFLLISACWVISLILgGLPimgWNCIGSLPSCSTVLPLYHKHY----------- 158
Cdd:cd15212   91 TMTLISFDRYYAIVRQPQGKIG-RRRALQLLAAAWLTALGF-SLP---WYLLASAPEYYEKLGFYHCLYvlhsgpsrlga 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 159 ------ILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNISKAsrSSEKSLAllKTVIIVLSVFIACWAPLFILL 232
Cdd:cd15212  166 ayssvlIVLCYLLPFALMCFCHYNICKTVRLSESRVRPVTTYAHLLRF--YSEMRTA--TTVLIMIVFIICCWGPYCLLG 241
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 347452693 233 LLDVGCKVKTCQILYKAEYFLVLAvlNSGTNPIIYTLTN 271
Cdd:cd15212  242 LVAAAGGYQFPPLMDTVAIWMAWA--NGAINPLIYAIRN 278
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
6-48 2.65e-03

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 38.95  E-value: 2.65e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDL 48
Cdd:cd15228    5 VLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDI 47
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
6-48 2.79e-03

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 38.59  E-value: 2.79e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDL 48
Cdd:cd15225    5 VVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEI 47
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
6-100 2.93e-03

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 38.54  E-value: 2.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPaqwFLREGS-MFVAL 84
Cdd:cd15429    5 VLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTIS---FASCVAqLFISL 81
                         90
                 ....*....|....*....
gi 347452693  85 S--ASVFSLLAI-AIERYI 100
Cdd:cd15429   82 AlgGTEFILLAVmAYDRYV 100
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
2-129 3.57e-03

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 38.35  E-value: 3.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   2 KLTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDllagVAY--------IANLLLSGAT-TYKLTPAQ 72
Cdd:cd15939    1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFID----ICYssttapklIVDLLSERKTiSFNGCMTQ 76
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 347452693  73 WFlreGSMFVAlSASVFSLLAIAIERYITMLKmKLHNGSNSSRS--FLLISACWVISLI 129
Cdd:cd15939   77 LF---AEHFFG-GAEIFLLTVMAYDRYVAICK-PLHYTTIMNRRvcGLLVGVAWVGGFL 130
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
16-148 3.62e-03

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 38.52  E-value: 3.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDllagvayianLLLSGATTYKLTPAQWF-LREGS------------MFV 82
Cdd:cd15952   15 LLGNCTILFVIKTEQSLHQPMFYFLAMLSTID----------LGLSTATIPKMLGIFWFnLREISfggclaqmffihTFT 84
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 347452693  83 ALSASVfsLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMgwNCIGSLPSCS 148
Cdd:cd15952   85 GMESAV--LVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFV--FLILRLPFCG 146
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
6-100 4.00e-03

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 38.35  E-value: 4.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLL---LSGATTYKLTP--AQWFLregsM 80
Cdd:cd15229    5 LVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLenlLSERKTISVEGciAQIFF----F 80
                         90       100
                 ....*....|....*....|
gi 347452693  81 FVALSASVFSLLAIAIERYI 100
Cdd:cd15229   81 FFFAGTEAFLLSAMAYDRYA 100
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
7-129 4.15e-03

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 38.12  E-value: 4.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   7 VFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLS-----GATTYKLTPAQWFLregSMF 81
Cdd:cd15406   15 LFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNfvsekNIISYPECMTQLFF---FCV 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 347452693  82 VALSASvFSLLAIAIERYITMLKMKLHNGSNSSRS-FLLISACWVISLI 129
Cdd:cd15406   92 FAIAEC-YMLTAMAYDRYVAICNPLLYNVTMSPRVcSLLVAGVYIMGLI 139
7tmA_GPR142 cd15129
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G ...
28-277 4.29e-03

G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320257 [Multi-domain]  Cd Length: 270  Bit Score: 38.22  E-value: 4.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  28 KTKKfhrPMYYFIGNLALSDLLAGVAYI-ANLLLSGATTYKLTPaQWFLREGSM--FVALSASVFSLLAIAIERYITMLK 104
Cdd:cd15129   31 RTKK---SSYYYLLALTASDILTQVFIIfVGFILQTAILAREVP-HALIHTVSVleFAANHASIWITVLLTVDRYVALCH 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 105 MKLHNG-SNSSRSFLLISACWVISLiLGGLPIMGWNCIGSLPSCST----VLPLYHKHYILFCTtvftlllltivilyCR 179
Cdd:cd15129  107 PLRYRAvSYPERTRRIIAAVFVAAL-ATGIPFYWWSDMWRDSHPPTtldkVLKWTHCFIIYFIP--------------CT 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 180 IYSLVRTR-SRRLTFRKNISKASRSSEKSLALLktvIIVLSVFIACWAP--LFILLLLDVGCKVKTCQILYKAEYFLVLA 256
Cdd:cd15129  172 IFLVTNSViIHKLRRRKGRSGPQRRSGKTTAIL---LAITTVFAVLWAPrtVVIIYHLYVSSVNRDWRVHLALDLANMLA 248
                        250       260
                 ....*....|....*....|.
gi 347452693 257 VLNSGTNPIIYTLTNKEMRRA 277
Cdd:cd15129  249 MLNTAVNFFLYCFVSKRFRRT 269
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
6-129 4.46e-03

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 38.08  E-value: 4.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDL----LAGVAYIANLLLSGAT-TYKLTPAQWFLregSM 80
Cdd:cd15936    5 LVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDIsfssVTAPKMLSDLLSQTKTiSFNGCMAQMFF---FH 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 347452693  81 FVAlSASVFSLLAIAIERYITMLKmKLHNGS--NSSRSFLLISACWVISLI 129
Cdd:cd15936   82 FTG-GAEVFLLSVMAYDRYIAIHK-PLHYLTimNQGVCTGLVAGSWLGGFA 130
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
19-275 5.09e-03

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 37.89  E-value: 5.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  19 NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayianLLLSGATTYKLTPAQWFLREG-------SMFVALSASV--F 89
Cdd:cd15080   18 NFLTLYVTVQHKKLRTPLNYILLNLAVADLF--------MVFGGFTTTMYTSMHGYFVFGptgcnleGFFATLGGEIalW 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  90 SLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCI---GSLPSCS----TVLPLYHKHYILFC 162
Cdd:cd15080   90 SLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYipeGMQCSCGidyyTLKPEVNNESFVIY 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 163 TTVFTLLLLTIVILYCriYSLVRTRSRRLTFRKNISKASRSSEKSLAllKTVIIVLSVFIACWAPlfillLLDVGCKVKT 242
Cdd:cd15080  170 MFVVHFTIPLIVIFFC--YGRLVCTVKEAAAQQQESATTQKAEKEVT--RMVIIMVIAFLICWVP-----YASVAFYIFT 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 347452693 243 CQILYKAEYFLVLAVLNSGT----NPIIYTLTNKEMR 275
Cdd:cd15080  241 HQGSDFGPIFMTIPAFFAKSsavyNPVIYILMNKQFR 277
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
19-130 5.27e-03

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 37.86  E-value: 5.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  19 NIFVLLTIWKTKKFHRPMYYFIGNLALSDL-LAGVAYIANLLLSgaTTYKLTPAQWFLREGSMFVALS--ASVFSLLAIA 95
Cdd:cd15386   18 NLAVLLAMYRMRRKMSRMHLFVLHLALTDLvVALFQVLPQLIWE--ITYRFQGPDLLCRAVKYLQVLSmfASTYMLIMMT 95
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 347452693  96 IERYITMLKMKLHNGSNSSRSFLLISACWVISLIL 130
Cdd:cd15386   96 VDRYIAVCHPLRTLQQPSRQAYLMIGATWLLSCIL 130
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
6-129 5.41e-03

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 37.84  E-value: 5.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMFVA-L 84
Cdd:cd15944   18 VVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKVISFSGCATQFAFFVGfV 97
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 347452693  85 SASVFSLLAIAIERYITMLKMKLHNGSNSSRSFL-LISACWVISLI 129
Cdd:cd15944   98 DAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLqLMAGSYLAGLV 143
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
6-128 5.92e-03

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 37.67  E-value: 5.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLREGSMFVALS 85
Cdd:cd15915    5 VLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLG 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 347452693  86 ASVFSLLAI-AIERYITMLK-MKLHNGSNSSRSFLLISACWVISL 128
Cdd:cd15915   85 SSEAMLLAVmAYDRYVAICNpLRYTVIMNPQVCLLLAVACWVTGF 129
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
3-278 6.07e-03

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 37.87  E-value: 6.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHR--PMYYFIGNLALSDLLAgVAYIANLLLSGATTYKLTPAQWFLREGSM 80
Cdd:cd14976    2 LVSVVYMVVFTVGLLGNLLVLYLLKSNKKLRQqsESNKFVFNLALTDLIF-VLTLPFWAVEYALDFVWPFGTAMCKVVRY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  81 FVALS--ASVFSLLAIAIERYITMLKMKLHNGSNSSR-SFLLISACWVISLILG---------GLPIMGWN-CIGSLPSC 147
Cdd:cd14976   81 VTKLNmySSIFFLTALSVTRYIAVARALKHGWIRKAFgAFATTIAIWAAAALAAipeaifstdTWSSVNHTlCLLRFPKN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 148 STV------LPLYHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRltfrkNISKASRSsekslallkTVIIVLSVF 221
Cdd:cd14976  161 SSVtrwynwLGMYQLQKVVLGFFLPLGIITLSYLLLLRFLQRKRGGSKR-----RKSRVTKS---------VFIVVLSFF 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 347452693 222 IaCWAPLFILLLLdvGCKVKTCQILYKAEYFLV----------LAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd14976  227 I-CWLPNQALSLW--SALIKFDDVPFSDAFFAFqtyafpvaicLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
3-277 6.72e-03

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 37.70  E-value: 6.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   3 LTTVVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvayiANLLLSGATTYKLTPAQWFLREG---- 78
Cdd:cd15389    2 LLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDIL------ITLLNTPFTLVRFVNSTWVFGKImchl 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  79 ---SMFVALSASVFSLLAIAIERYITML-----KMKLHNGSnssrsfLLISACWVISLILgGLPIMGWN----------- 139
Cdd:cd15389   76 srfAQYCSVYVSTLTLTAIALDRHRVILhplkpRITPCQGV------VVIAIIWIMASCL-SLPHAIYQklvefeysner 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 140 ----CIGSLPSCSTvlpLYHKHYILFCTTVFTLL-LLTIVILYCRIyslvrtrSRRLTFRKNISKAS--------RSSEK 206
Cdd:cd15389  149 trsrCLPSFPEPSD---LFWKYLDLATFILQYVLpLLIIGVAYTRV-------AKKLWLRNAIGDVTteqyvaqrRKKKK 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 347452693 207 SLALLKTVIIVLSVfiaCWAPL-FILLLLDVGcKVKTCQILYKAeyFLVLAVLNSGTNPIIYTLTNKEMRRA 277
Cdd:cd15389  219 TIKMLMLVVLLFAI---CWLPLnCYHVLLSSH-PIRSNSALFFA--FHWLAMSSTCYNPFIYCWLNDSFRSE 284
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
6-278 6.99e-03

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 37.54  E-value: 6.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGV-----AYIANLL---LSGATTYKLTPaqWFlre 77
Cdd:cd15978    5 LLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLfcmpfTLIPNLLkdfIFGSAVCKTAT--YF--- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  78 gsMFVALSASVFSLLAIAIERYITMLK-MKLHNGSNSSRSFLLISACWVIS-LILGGLPIMGW--------NCIGSLpsC 147
Cdd:cd15978   80 --MGISVSVSTFNLVAISLERYSAICKpLKSRVWQTKSHALKVIAATWCLSfTIMLPYPIYSNlvpftrinNSTGNM--C 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693 148 STVLP--LYHKHYILFCTTVFTLLLLTIVILYCRIYSLVRTRSRRLTFRKNiskasrssekslALLKTVIIVLSVFIACW 225
Cdd:cd15978  156 RLLWPndVTQQSWYIFLLLILFLIPGIVMMTAYGLISLELYRGIKFLMAKK------------RVIRMLIVIVILFFLCW 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 347452693 226 APLFILLLLDVGCKVKTCQILYKA--EYFLVLAVLNSGTNPIIYTLTNKEMRRAF 278
Cdd:cd15978  224 TPIFSANAWRAFDTRSADRLLSGApiSFIHLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
6-113 7.30e-03

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 37.45  E-value: 7.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLL-----SGATTYKLTPAQWFLREGSM 80
Cdd:cd15418    6 VVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILAdciskDKSISFAGCAAQFFFSAGLA 85
                         90       100       110
                 ....*....|....*....|....*....|...
gi 347452693  81 FvalsASVFSLLAIAIERYITMLKMKLHNGSNS 113
Cdd:cd15418   86 Y----SECFLLAAMAYDRYVAICNPLLYSSAMS 114
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
6-100 8.91e-03

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 37.25  E-value: 8.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLL-----SGATTYKLTPAQWFLreGSM 80
Cdd:cd15410   18 LVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVnflaeDKAISYSGCMLQFFF--FCT 95
                         90       100
                 ....*....|....*....|
gi 347452693  81 FValSASVFSLLAIAIERYI 100
Cdd:cd15410   96 FV--VTESFLLAVMAYDRYV 113
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
16-160 9.09e-03

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 37.06  E-value: 9.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  16 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLreGSMFVALSASVFS---LL 92
Cdd:cd15949   31 VLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSSNEIPLHACL--LQMFLIHSFSAIEsgiFL 108
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 347452693  93 AIAIERYITMlkmklhngSNSSRSFLLISACWVISLILGGLpIMGWNCIGSLPSCSTVLPLYHKHYIL 160
Cdd:cd15949  109 AMAFDRYVAI--------CNPLRHKTILTNTTVIRIGLAAV-IRGVLYISPLPLLVRRLPWYRTNIIA 167
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
6-135 9.42e-03

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 37.08  E-value: 9.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693   6 VVFILICCCIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLagvaYIANLL-------LSGATTYKLTP--AQWFLr 76
Cdd:cd15911    5 LLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEIC----YTSTILprmlaslLTGDRTISVSGciVQFYF- 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 347452693  77 egsmFVALSASVFSLLAI-AIERYITMLKmKLHNGS--NSSRSFLLISACWVISLILGGLPI 135
Cdd:cd15911   80 ----FGSLAATECYLLAVmSYDRYLAICK-PLHYASlmNGRLCLQLAAGSWISGFLASTITV 136
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
19-127 9.50e-03

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 37.21  E-value: 9.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347452693  19 NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYK-------LTPAQWFLregsMFVALSAsvFSL 91
Cdd:cd15918   18 NLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKsisyagcLTQMYFFL----LFGDLDN--FLL 91
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 347452693  92 LAIAIERYITMLKmKLHNGS--NSSRSFLLISACWVIS 127
Cdd:cd15918   92 AVMAYDRYVAICH-PLHYTTimSPRLCILLVAASWVIT 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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