BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  10 KSMSLDYLNLLINGQ-AFSDVTFSVE-GRLVHAHRCILAARSLFFRKFFCESDPSQPGAEPANQtgsgaraaaVGGVIPV 87
Cdd:cd18310    1 KKLSSDLENLLDSPDlFYSDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLE---------LRELIPG 71

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  88 NSVGYEVFLLLLQFLYSGQVSIVPhkhEPRSNCGDRGCWHTHCTAAVDLSLDILAAARYFGVEQLALLTQ 157
Cdd:cd18310   72 GIVGYDAFMLVLSYLYSGRLRLVP---KEGSACVDSDCWHVACRPAVDFALEVLYAASVFQIPELVSLFQ 138

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  10 KSMSLDYLNLLINGQ-AFSDVTFSVE-GRLVHAHRCILAARSLFFRKFFCESDPSQPGAEPANQtgsgaraaaVGGVIPV 87
Cdd:cd18310    1 KKLSSDLENLLDSPDlFYSDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLE---------LRELIPG 71

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  88 NSVGYEVFLLLLQFLYSGQVSIVPhkhEPRSNCGDRGCWHTHCTAAVDLSLDILAAARYFGVEQLALLTQ 157
Cdd:cd18310   72 GIVGYDAFMLVLSYLYSGRLRLVP---KEGSACVDSDCWHVACRPAVDFALEVLYAASVFQIPELVSLFQ 138

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097    28 DVTFSVEGRLVHAHRCILAARSLFFRKFFCESDPSQPGAEpanqtgsgaraaavggvIPVNSVGYEVFLLLLQFLYSGQV 107
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSE-----------------IYLDDVSPEDFRALLNFLYTGKL 63

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 332646097   108 SIvphkhePRSNCgdrgcwhthctaavdlsLDILAAARYFGVEQLALLTQCNFLSR 163
Cdd:smart00225  64 DL------PEENV-----------------EELLELADYLQIPGLVELCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  10 KSMSLDYLNLLINGQ-AFSDVTFSVE-GRLVHAHRCILAARSLFFRKFFCESDPSQPGAEPANQtgsgaraaaVGGVIPV 87
Cdd:cd18310    1 KKLSSDLENLLDSPDlFYSDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLE---------LRELIPG 71

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  88 NSVGYEVFLLLLQFLYSGQVSIVPhkhEPRSNCGDRGCWHTHCTAAVDLSLDILAAARYFGVEQLALLTQ 157
Cdd:cd18310   72 GIVGYDAFMLVLSYLYSGRLRLVP---KEGSACVDSDCWHVACRPAVDFALEVLYAASVFQIPELVSLFQ 138

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097   5 FEESLKSmsldylnlLINGQAFSDVTFSV--EGRLVHAHRCILAARSLFFRKFFCEsdpsQPGAEPANQTgsgaraaavg 82
Cdd:cd18294    1 FAADMKS--------LINNPEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLT----GPQKESTQSP---------- 58

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  83 gvIPVNSVGYEVFLLLLQFLYSGQVSIVPHkheprsncgdrgcwhthctaavdLSLDILAAARYFGVEQL 152
Cdd:cd18294   59 --LVLSDIEPEVFRAVLEFIYTNCVTLSNH-----------------------TVIEVLAAAVEYGLDEL 103

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097   17 LNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCESDPSQPGAEpanqtgsgaraaavggvIPVNSVGYEVFL 96
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSE-----------------ITLDDVSPEDFE 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 332646097   97 LLLQFLYSGQVsivphkhEPRSNcgdrgcwhthctaavdlSLDILAAARYFGVEqlALLTQC 158
Cdd:pfam00651  64 ALLEFMYTGKL-------ISEEN-----------------VDDLLAAADKLQIP--SLVDKC 99

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097    28 DVTFSVEGRLVHAHRCILAARSLFFRKFFCESDPSQPGAEpanqtgsgaraaavggvIPVNSVGYEVFLLLLQFLYSGQV 107
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSE-----------------IYLDDVSPEDFRALLNFLYTGKL 63

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 332646097   108 SIvphkhePRSNCgdrgcwhthctaavdlsLDILAAARYFGVEQLALLTQCNFLSR 163
Cdd:smart00225  64 DL------PEENV-----------------EELLELADYLQIPGLVELCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  26 FSDVTFSVEGRLVHAHRCILAARSLFFRKFFCESDPSQPgaepanqtgsgaraaavgGVIPVNSVGYEVFLLLLQFLYSG 105
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEH------------------PVIILPDVPYSELKALLDFIYTG 62

                 ....
gi 332646097 106 QVSI 109
Cdd:cd18315   63 EVNV 66

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  21 INGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcesdpsqpgaepanqtgSGARAAAVGGVIPVNSVGYEVFLLLLQ 100
Cdd:cd18352    8 VNNATLSDVTFLVEGRRFYAHRIALLASSDAFRAMF-----------------DGGYREKEARDIEIPNIRWEVFELMMR 70

                         90
                 ....*....|..
gi 332646097 101 FLYSGQVSIVPH 112
Cdd:cd18352   71 FIYTGSVDITND 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  15 DYLNLLINGQAfSDVTFSVEGRLVHAHRCILAARSLFFR-KFFcesdpsqpgaepanqtgsGARAAAVGGVIPVNSVGYE 93
Cdd:cd18280    4 HFGALLESEEG-ADVTFNVDGEKFRAHKLVLAARSPVFRsMLF------------------GPMREENEGEIVIEDVEPP 64

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 332646097  94 VFLLLLQFLYSGQvsiVPHKHEPRSNcgdrgcwhTHCTAAVDLSLDILAAARYFGVEQLALL 155
Cdd:cd18280   65 VFKALLHFIYKDE---LPDDVEPAGS--------DSSSLDTTMAQHLLAAADRYALERLRLL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  17 LNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcesdpsqpgaepanqtgSGARAAAVGGVIPVNSVGYEVFL 96
Cdd:cd18250   12 LSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMF-----------------AGELRESRADRVVLHGVSAEILG 74

                         90       100
                 ....*....|....*....|
gi 332646097  97 LLLQFLYSGQVSIVPHKHEP 116
Cdd:cd18250   75 LLLDFSYTGRVTVTQDNVEA 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  15 DYLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFF-CESDPSQPGAepanqtgsgaraaavggvIPVNSVGYE 93
Cdd:cd18279    7 EDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFeHEMEESKKNR------------------VEINDVDPE 68

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 332646097  94 VFLLLLQFLYSGQvsiVPHKHEprsncgdrgcwhthctaavdLSLDILAAARYFGVEQLALLTQ---CNFLS 162
Cdd:cd18279   69 VFKEMMRFIYTGK---APNLDK--------------------MADDLLAAADKYALERLKVMCEdalCSNLS 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  20 LINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcesdPSQPGAEpanqtgsgaraaavGGVIPVNSVGYEVFLLLL 99
Cdd:cd18351   18 FLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALL----SNKPSAE--------------NTCIEISYVKYHIFQLVM 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 332646097 100 QFLYsgqvsivphkheprsnCGDRGCWHTHCTAAVDLsldiLAAARYFGVEQL 152
Cdd:cd18351   80 QYLY----------------CGGTESLLIKNNEIMEL----LSAAKFFQLEAL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  22 NGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcESDPsqpgaEPANQtgsgaraaavGGVIPVNSVGYEVFLLLLQF 101
Cdd:cd18293   11 NSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERL-SSEP-----PPAGQ----------KVVLELQGLKAHTLLKLVDF 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 332646097 102 LYSGQVSIVPHKHEprsncgdrgcwhthctaavdlslDILAAARYFGVEQLALL 155
Cdd:cd18293   75 LYTSELEVSSEEAQ-----------------------DVLAAARRLQISELESL 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  11 SMSLDYLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFC-ESDPSQPGAEPANQTgsgaraaavggVIPVNS 89
Cdd:cd18228    4 QELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVgQASPRLVLVSPAGKC-----------VLDLHH 72

                         90       100
                 ....*....|....*....|
gi 332646097  90 VGYEVFLLLLQFLYSGQVSI 109
Cdd:cd18228   73 VTVTGFAPLLEYAYTSTLSI 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  20 LINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFF---CESDPSQPGAE----PANQTgsgaraaavggvipvnsvgy 92
Cdd:cd18292   11 LYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLsndWWSESKQSEIElvedPECAA-------------------- 70

                         90
                 ....*....|....*..
gi 332646097  93 eVFLLLLQFLYSGQVSI 109
Cdd:cd18292   71 -VFEKFLRYLYTGQISV 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  21 INGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCESdpsqpgaepANQTGSGARAaavggvIPVNSVGYEVFLLLLQ 100
Cdd:cd18350   19 LNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNK---------SEQESQGSKT------IEISDIKYHIFQMLMQ 83

                 ....*
gi 332646097 101 FLYSG 105
Cdd:cd18350   84 YLYYG 88

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  17 LNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcesdpsqpgaepanqtgSGARAAAVGGVIPVNSVGYEVFL 96
Cdd:cd18360    1 LGLFFNSPLLADVVFKIQGTTVPAHRAVLVARCEVMAAMF-----------------NGNYAEAKSFLVPIYGVSKDTFL 63

                 ....*...
gi 332646097  97 LLLQFLYS 104
Cdd:cd18360   64 SFLEYLYT 71

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  14 LDYLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCESDPSQPGAEPANQTGSGARAaavggvipvnsvgyE 93
Cdd:cd18258    5 LKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEKLELTMSNINA--------------D 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 332646097  94 VFLLLLQFLYSGQVSIVPHKHEPRSNCGDRGCWHTHCTAAVDLSLDILAAARYFG 148
Cdd:cd18258   71 VLELLLEFVYTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  26 FSDVTFSVEGRLVHAHRCILAARSLFFRKFFCesdpsqpgaepanqtgsgaraaAVGGVIPVNSVGYEVFLLLLQFLYSG 105
Cdd:cd18219   21 FCDVTVIVEDRKFRAHKNILSASSTYFHQLFS----------------------VAGQVVELNFIRADIFAEILNYIYSS 78

                 ..
gi 332646097 106 QV 107
Cdd:cd18219   79 KI 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  15 DYLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcesdpsqpgaEPANQTGSGARaaavggvIPVNSVGYEV 94
Cdd:cd18343   10 EDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMF----------EHEMEESKKNR-------VEINDVDPEV 72

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 332646097  95 FLLLLQFLYSGQvsiVPHKHEPRSNcgdrgcwhthctaavdlsldILAAARYFGVEQLALLTQ---CNFLS 162
Cdd:cd18343   73 FKEMMRFIYTGK---APNLDKMADN--------------------LLAAADKYALERLKVMCEealCNNLS 120

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  27 SDVTFSVEGRLVHAHRCILAARSLFFRKFFCESdpsqPGAepanqtgsgaraaavGGVIPVN--SVGYEV--FLLLLQFL 102
Cdd:cd18283    3 TDVDLVFQGTCFPVHRAILSARCPFFRDLLSSS----PGY---------------GAEIPVDlpTAGIDVpmFSALLRYL 63

                 ....*.
gi 332646097 103 YSGQVS 108
Cdd:cd18283   64 YTGEFG 69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  27 SDVTFSVEGRLVHAHRCILAARSLFFRKFFcESDPSQPGAEpanqtgsgaraaavggVIPVNSVGYEVFLLLLQFLYSGQ 106
Cdd:cd18353   21 SDLKFRVDGKYIHVHKAVLKIRCEHFRTMF-QSHWNEDMKE----------------VIEIDQFSYPVYRAFLEYLYTDS 83

                 ....*
gi 332646097 107 VSIVP 111
Cdd:cd18353   84 VDLPP 88

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  28 DVTFSVEGRLVHAHRCILAARSLFFRKFFCesdpsqpgaepanqtgSGARAAAvGGVIPVNSVGYEVFLLLLQFLYSGQV 107
Cdd:cd18263   15 DVQLEADGSIFRVHRVILAAGSDYFRAMFT----------------SGMKEST-QSVVQLPTIPAKDLRLLISFAYSGIL 77

                 .
gi 332646097 108 S 108
Cdd:cd18263   78 H 78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  25 AFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcesdpsqpgaepANQTgsgarAAAVGGVIPVNSVGYEVFLLLLQFLYS 104
Cdd:cd18223   17 ILCDVTIVVEDTKFKAHKNVLAASSLYFKNAF------------SSQE-----IWISSHVLELPDLKAEVFAEILNFIYS 79

                 ....*
gi 332646097 105 GQVSI 109
Cdd:cd18223   80 SKVVV 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  13 SLDYLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcesdpsqpgaepanqtgSGARAAAVGGVIPVNSVGY 92
Cdd:cd18238    2 SFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMF-----------------TSEMAESKQDSITIKDIDE 64

                         90
                 ....*....|....*..
gi 332646097  93 EVFLLLLQFLYSGQVSI 109
Cdd:cd18238   65 EAVELLVDFAYTGKLTL 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  27 SDVTFSVEGRLVHAHRCILAARSLFFRKFFCESDPSqpgaepanqtgsgaraaavggVIPVNSVGYEVFLLLLQFLYSGQ 106
Cdd:cd18354   21 ADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEE---------------------IIEMSQFSYPVYRAFLEYLYTDS 79

                 ....*
gi 332646097 107 VSIVP 111
Cdd:cd18354   80 ISLSP 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  14 LDYLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcesdpsqpgaepanqtGSGARAAAVGGVIPVNSVGYE 93
Cdd:cd18254   10 LTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMF----------------SNGLRESLDSTVNFHDSLHPE 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 332646097  94 VFLLLLQFLYSGQVSIVPHKHEPRSNCGDRGCWHTHCTAAVDL 136
Cdd:cd18254   74 VLELLLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEF 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 332646097  14 LDYLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCE 58
Cdd:cd18202    7 LDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIE 51

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  26 FSDVTFSVEGRLVHAHRCILAARSLFFRKFFCESDPSQPGAEPANQTGSgaraaavggvipvnsvgyevFLLLLQFLYSG 105
Cdd:cd18290   27 YCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQS--------------------FQQILSFCYTG 86

                 ....
gi 332646097 106 QVSI 109
Cdd:cd18290   87 RLSM 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  26 FSDVTFSVEGRLVHAHRCILAARSLFFRKFFCESdpSQPGAEPANQTgsgaraaavggvipVNSVGYEVFLLLLQFLYSG 105
Cdd:cd18199   18 FCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHY--IQDTGRPSTAS--------------FDVFSSDAFSIILDFVYSG 81

                 ....
gi 332646097 106 QVSI 109
Cdd:cd18199   82 KLSL 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332646097  26 FSDVTFSVEGRLVHAHRCILAARSLFFRKFF--CESDPSQpgaepanqtgsgaraaavggVIPVNSVGYEVFLLLLQFLY 103
Cdd:cd18204   18 FCDIAIVVEDVKFRAHRCVLAACSTYFKKLFkkLEVDSSS--------------------VIEIDFLRSDIFEEVLNYMY 77

                 ....*.
gi 332646097 104 SGQVSI 109
Cdd:cd18204   78 TAKISV 83