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Conserved domains on  [gi|332192325|gb|AEE30446|]
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NHL domain-containing protein [Arabidopsis thaliana]

Protein Classification

NHL repeat-containing protein( domain architecture ID 110303)

NHL (NCL-1, HT2A and LIN-41) repeat-containing protein may have a catalytic activity or interact with other proteins; NHL is a six-bladed beta-propeller

CATH:  2.40.10.500
Gene Ontology:  GO:0005515
PubMed:  9868369|17979191

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 79-184 4.11e-24

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14953:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 323  Bit Score: 101.45  E-value: 4.11e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  79 INRFAGDGSSGHVDGKAGNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTTIAGGisKAFGHRDGPAQNATFSS 158
Cdd:cd14953    1 VSTVAGSGTAGFSGGGGTAARFNSPSGVAVDAAGNLYVADRGNHRIRKITPDGVVTTVAGT--GTAGFADGGGAAAQFNT 78

                         90       100
                 ....*....|....*....|....*.
gi 332192325 159 DFEITFVPQRcCLLVSDHGNEMIRQI 184
Cdd:cd14953   79 PSGVAVDAAG-NLYVADTGNHRIRKI 103
 
Name Accession Description Interval E-value
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 79-184 4.11e-24

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 101.45  E-value: 4.11e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  79 INRFAGDGSSGHVDGKAGNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTTIAGGisKAFGHRDGPAQNATFSS 158
Cdd:cd14953    1 VSTVAGSGTAGFSGGGGTAARFNSPSGVAVDAAGNLYVADRGNHRIRKITPDGVVTTVAGT--GTAGFADGGGAAAQFNT 78

                         90       100
                 ....*....|....*....|....*.
gi 332192325 159 DFEITFVPQRcCLLVSDHGNEMIRQI 184
Cdd:cd14953   79 PSGVAVDAAG-NLYVADTGNHRIRKI 103
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 89-193 3.61e-09

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 58.71  E-value: 3.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325   89 GHVDGKAGNSRFSKPRGFAVDAKGNVYVADKSNKAIRKIS-SSGSVTTIAgGISKAfGHRDGPAQNATFSSDFEITFVPQ 167
Cdd:PLN02919  792 GDHDGVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIKKLDpATKRVTTLA-GTGKA-GFKDGKALKAQLSEPAGLALGEN 869

                          90       100
                  ....*....|....*....|....*.
gi 332192325  168 RcCLLVSDHGNEMIRQINLKEEDCLE 193
Cdd:PLN02919  870 G-RLFVADTNNSLIRYLDLNKGEAAE 894
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
33-137 1.66e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 49.25  E-value: 1.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  33 TVVDGHKSG-LNP----YTIHALPGSSNL---IVLDSSGSTFYTTSFplsvDSVINRFagDGSSGHVDGKAGNSRFSKPR 104
Cdd:COG4257  118 TDQGGNRIGrLDPatgeVTEFPLPTGGAGpygIAVDPDGNLWVTDFG----ANAIGRI--DPDTGTLTEYALPTPGAGPR 191

                         90       100       110
                 ....*....|....*....|....*....|....
gi 332192325 105 GFAVDAKGNVYVADKSNKAIRKIS-SSGSVTTIA 137
Cdd:COG4257  192 GLAVDPDGNLWVADTGSGRIGRFDpKTGTVTEYP 225
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 54-148 2.36e-03

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 39.17  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325   54 SNLIVLDSSGSTFYTTsfplsvDSVINR---FAGDGSSG-------HVDGKAGNSRfskPRGFAVDAKGNVYVADKSNKA 123
Cdd:pfam08450 136 SNGLAWSPDGRTLYFA------DSPARKiwaYDYDLDGGlisnrrvFADFKPGLGR---PDGMAVDAEGNVWVARWGGGK 206

                          90       100       110
                  ....*....|....*....|....*....|
gi 332192325  124 IRKISSSGSVTTI----AGGISK-AFGHRD 148
Cdd:pfam08450 207 VVRFDPDGKLLREielpAKRPTScAFGGPD 236
 
Name Accession Description Interval E-value
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 79-184 4.11e-24

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 101.45  E-value: 4.11e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  79 INRFAGDGSSGHVDGKAGNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTTIAGGisKAFGHRDGPAQNATFSS 158
Cdd:cd14953    1 VSTVAGSGTAGFSGGGGTAARFNSPSGVAVDAAGNLYVADRGNHRIRKITPDGVVTTVAGT--GTAGFADGGGAAAQFNT 78

                         90       100
                 ....*....|....*....|....*.
gi 332192325 159 DFEITFVPQRcCLLVSDHGNEMIRQI 184
Cdd:cd14953   79 PSGVAVDAAG-NLYVADTGNHRIRKI 103
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 43-184 1.06e-23

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 100.30  E-value: 1.06e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  43 NPYTIhALPGSSNLIVLDSSGSTFyttsFPLSVDSVINRFAGDGSSGHVDGKAGNSRFSKPRGFAVDAKGNVYVADKSNK 122
Cdd:cd14953   24 SPSGV-AVDAAGNLYVADRGNHRI----RKITPDGVVTTVAGTGTAGFADGGGAAAQFNTPSGVAVDAAGNLYVADTGNH 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 332192325 123 AIRKISSSGSVTTIAGGiSKAFGHRDGPAQNATFSSDFEITFVPQRcCLLVSDHGNEMIRQI 184
Cdd:cd14953   99 RIRKITPDGVVSTLAGT-GTAGFSDDGGATAAQFNYPTGVAVDAAG-NLYVADTGNHRIRKI 158
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 43-184 3.38e-23

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 98.76  E-value: 3.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  43 NPYTIhALPGSSNLIVLDSSGSTFyttsFPLSVDSVINRFAGDGSSGHV-DGKAGNSRFSKPRGFAVDAKGNVYVADKSN 121
Cdd:cd14953  188 NPTGV-AVDAAGNLYVADRGNHRI----RKITPDGVVTTVAGTGTAGFSgDGGATAAQLNNPTGVAVDAAGNLYVADSGN 262

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 332192325 122 KAIRKISSSGSVTTIAGGISKAFGhRDGPAQNATFSSDFEITFVPQRcCLLVSDHGNEMIRQI 184
Cdd:cd14953  263 HRIRKITPAGVVTTVAGGGAGFSG-DGGPATSAQFNNPTGVAVDAAG-NLYVADTGNNRIRKI 323
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 74-185 3.66e-23

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 98.76  E-value: 3.66e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  74 SVDSVINRFAGDGSSG-HVDGKAGNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTTIAGGISKAFGHrDGPAQ 152
Cdd:cd14953  159 TPDGVVTTVAGTGGAGyAGDGPATAAQFNNPTGVAVDAAGNLYVADRGNHRIRKITPDGVVTTVAGTGTAGFSG-DGGAT 237

                         90       100       110
                 ....*....|....*....|....*....|...
gi 332192325 153 NATFSSDFEITfVPQRCCLLVSDHGNEMIRQIN 185
Cdd:cd14953  238 AAQLNNPTGVA-VDAAGNLYVADSGNHRIRKIT 269
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 78-184 2.95e-22

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 96.45  E-value: 2.95e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  78 VINRFAGDGSSGHVDGKAGNS-RFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTTIAGGiSKAFGHRDGPAQNATF 156
Cdd:cd14953  108 VVSTLAGTGTAGFSDDGGATAaQFNYPTGVAVDAAGNLYVADTGNHRIRKITPDGVVTTVAGT-GGAGYAGDGPATAAQF 186

                         90       100
                 ....*....|....*....|....*...
gi 332192325 157 SSDFEITFVPQRcCLLVSDHGNEMIRQI 184
Cdd:cd14953  187 NNPTGVAVDAAG-NLYVADRGNHRIRKI 213
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 84-138 2.40e-12

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 67.22  E-value: 2.40e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 332192325  84 GDGSSGHVDGKAGNSRFSKPRGFAVDAKGNVYVADKSNKAIRKIS-SSGSVTTIAG 138
Cdd:cd14951    2 GSGERGLKDGSFAEASFNEPQGLALLPGNILYVADTENHALRKIDlETGTVTTLAG 57
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 75-191 4.81e-12

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 66.45  E-value: 4.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  75 VDSVINRFAGDGSSGHVDGKAG-NSRFSKPRGFAVDAKGNVYVADKSNKAIRKIS-SSGSVTTIAGG--ISK---AFGHR 147
Cdd:cd14951  107 DTGTCRVFAGSGNEGNRNGPYPhEAWFAQPSGLSLAGWGELFVADSESSAIRAVSlKDGGVKTLVGGtrVGTglfDFGDR 186

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 332192325 148 DGPAQNATFSSDFEITFVPQRcCLLVSDHGNEMIRQINLKEEDC 191
Cdd:cd14951  187 DGPGAEALLQHPLGVAALPDG-SVYVADTYNHKIKRVDPATGEV 229
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 40-189 2.78e-11

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 64.14  E-value: 2.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  40 SGLnpytihALPGSSNLIVLDSSGSTFYTTSF------PLSVDSVI--NRFAGdgssGHVDGKAGNSRFSKPRGFAVDAK 111
Cdd:cd14951  137 SGL------SLAGWGELFVADSESSAIRAVSLkdggvkTLVGGTRVgtGLFDF----GDRDGPGAEALLQHPLGVAALPD 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325 112 GNVYVADKSNKAIRKI-SSSGSVTTIAGGisKAFGHRDGPAQnatFS--SDfeITFVPQRcCLLVSDHGNEMIRQINLKE 188
Cdd:cd14951  207 GSVYVADTYNHKIKRVdPATGEVSTLAGT--GKAGYKDLEAQ---FSepSG--LVVDGDG-RLYVADTNNHRIRRLDLPT 278


                 .
gi 332192325 189 E 189
Cdd:cd14951  279 E 279
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 57-150 2.22e-10

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 60.80  E-value: 2.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  57 IVLDSSGsTFYTTSfplSVDSVINRFAGDGSSGHVDGKAGN--SRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVT 134
Cdd:cd05819   60 VAVDSDG-NLYVAD---TGNHRIQKFDPDGNFLASFGGSGDgdGEFNGPRGIAVDSSGNIYVADTGNHRIQKFDPDGEFL 135

                         90
                 ....*....|....*.
gi 332192325 135 TIAGGISKAFGHRDGP 150
Cdd:cd05819  136 TTFGSGGSGPGQFNGP 151
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 57-151 7.72e-10

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 59.13  E-value: 7.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  57 IVLDSSGSTfYTTsfplsvDSVINR---FAGDG-------SSGhvdgkAGNSRFSKPRGFAVDAKGNVYVADKSNKAIRK 126
Cdd:cd14955  162 IAVDSAGNV-YVA------DTGNNRiqkFTSTGtfltkwgSEG-----SGDGQFNAPYGIAVDSAGNVYVADTGNNRIQK 229

                         90       100
                 ....*....|....*....|....*
gi 332192325 127 ISSSGSVTTIAGGISKAFGHRDGPA 151
Cdd:cd14955  230 FDSSGTFITKWGSEGSGDGQFNSPS 254
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 79-185 1.14e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 58.87  E-value: 1.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  79 INRFAGDGSSGHVDGKAGNS--RFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTTIAGGISKAFGHRDGPaQNATF 156
Cdd:cd05819   31 IQVFDPDGNFITSFGSFGSGdgQFNEPAGVAVDSDGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEFNGP-RGIAV 109

                         90       100
                 ....*....|....*....|....*....
gi 332192325 157 SSDFEItfvpqrcclLVSDHGNEMIRQIN 185
Cdd:cd05819  110 DSSGNI---------YVADTGNHRIQKFD 129
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 89-193 3.61e-09

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 58.71  E-value: 3.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325   89 GHVDGKAGNSRFSKPRGFAVDAKGNVYVADKSNKAIRKIS-SSGSVTTIAgGISKAfGHRDGPAQNATFSSDFEITFVPQ 167
Cdd:PLN02919  792 GDHDGVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIKKLDpATKRVTTLA-GTGKA-GFKDGKALKAQLSEPAGLALGEN 869

                          90       100
                  ....*....|....*....|....*.
gi 332192325  168 RcCLLVSDHGNEMIRQINLKEEDCLE 193
Cdd:PLN02919  870 G-RLFVADTNNSLIRYLDLNKGEAAE 894
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 95-185 1.26e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.40  E-value: 1.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  95 AGNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTTIAGGISKAFGHRDGPAQNATFSSDFeitfvpqrccLLVS 174
Cdd:cd05819  143 SGPGQFNGPTGVAVDSDGNIYVADTGNHRIQVFDPDGNFLTTFGSTGTGPGQFNYPTGIAVDSDGN----------IYVA 212

                         90
                 ....*....|.
gi 332192325 175 DHGNEMIRQIN 185
Cdd:cd05819  213 DSGNNRVQVFD 223
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 86-139 2.22e-08

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 54.89  E-value: 2.22e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 332192325  86 GSSGhvdgkAGNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTTIAGG 139
Cdd:cd14955   53 GSSG-----SGDGQFYSPTGIAVDSDGNVYVADTGNHRIQKFDSTGTFLTKWGS 101
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 96-185 3.85e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 54.25  E-value: 3.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  96 GNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTTIAGGISKAFGHRDGPAQNAtFSSDFEItfvpqrcclLVSD 175
Cdd:cd05819    3 GPGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPDGNFITSFGSFGSGDGQFNEPAGVA-VDSDGNL---------YVAD 72

                         90
                 ....*....|
gi 332192325 176 HGNEMIRQIN 185
Cdd:cd05819   73 TGNHRIQKFD 82
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 58-181 4.78e-08

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 53.81  E-value: 4.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  58 VLDSSGSTFYTtsfplsvdsvinrfAGDGSSGhvdgkagNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGS-VTTI 136
Cdd:cd14957  137 VFTSSGTFSYS--------------IGSGGTG-------PGQFNGPQGIAVDSDGNIYVADTGNHRIQVFTSSGTfQYTF 195

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 332192325 137 AGGISkafghrdGPAQnatFSSDFEITfVPQRCCLLVSDHGNEMI 181
Cdd:cd14957  196 GSSGS-------GPGQ---FSDPYGIA-VDSDGNIYVADTGNHRI 229
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 86-150 4.82e-08

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 53.73  E-value: 4.82e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 332192325  86 GSSGhvdgkAGNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTTIAGGISKAFGHRDGP 150
Cdd:cd14955  100 GSSG-----SGDGQFNSPSGIAVDSAGNVYVTDSGNNRIQKFDSSGTFITKWGSFGSGDGQFNSP 159
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 75-178 4.97e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 53.86  E-value: 4.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  75 VDSVINRFAGDGSSGHVDGkagnsRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTTIAGGISKAFGHRDGPaqna 154
Cdd:cd05819  175 FDPDGNFLTTFGSTGTGPG-----QFNYPTGIAVDSDGNIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQFNRP---- 245

                         90       100
                 ....*....|....*....|....
gi 332192325 155 tfssdFEITFVPQRcCLLVSDHGN 178
Cdd:cd05819  246 -----SGLAVDSDG-NLYVADTGN 263
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 57-132 2.15e-07

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 51.81  E-value: 2.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  57 IVLDSSGSTFYTtsfplsvDSVINR---FAGDG-------SSGhvdgkAGNSRFSKPRGFAVDAKGNVYVADKSNKAIRK 126
Cdd:cd14955  115 IAVDSAGNVYVT-------DSGNNRiqkFDSSGtfitkwgSFG-----SGDGQFNSPTGIAVDSAGNVYVADTGNNRIQK 182


                 ....*.
gi 332192325 127 ISSSGS 132
Cdd:cd14955  183 FTSTGT 188
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 86-131 4.49e-07

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 51.04  E-value: 4.49e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 332192325  86 GSSGHVDGkagnsRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSG 131
Cdd:cd14955    6 GSYGSGDG-----QFNSPSGIAVDSAGNVYVADTGNNRIQKFDSTG 46
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 79-166 9.46e-07

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 51.01  E-value: 9.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325   79 INRFAGDGSSGHVDGKAGNSRFSKPRGFAVDAKGNV-YVADKSNKAIRKIS-SSGSVTTIAGGISKAFGHRDGPA-QNAT 155
Cdd:PLN02919  602 IVQIGSTGEEGLRDGSFEDATFNRPQGLAYNAKKNLlYVADTENHALREIDfVNETVRTLAGNGTKGSDYQGGKKgTSQV 681

                          90
                  ....*....|.
gi 332192325  156 FSSDFEITFVP 166
Cdd:PLN02919  682 LNSPWDVCFEP 692
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
33-137 1.66e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 49.25  E-value: 1.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  33 TVVDGHKSG-LNP----YTIHALPGSSNL---IVLDSSGSTFYTTSFplsvDSVINRFagDGSSGHVDGKAGNSRFSKPR 104
Cdd:COG4257  118 TDQGGNRIGrLDPatgeVTEFPLPTGGAGpygIAVDPDGNLWVTDFG----ANAIGRI--DPDTGTLTEYALPTPGAGPR 191

                         90       100       110
                 ....*....|....*....|....*....|....
gi 332192325 105 GFAVDAKGNVYVADKSNKAIRKIS-SSGSVTTIA 137
Cdd:COG4257  192 GLAVDPDGNLWVADTGSGRIGRFDpKTGTVTEYP 225
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
45-144 1.90e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 48.86  E-value: 1.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  45 YTIHALPGSSNLIVlDSSGSTFYTTSFplsvDSVINRFagDGSSGHVDGKAGNSRFSKPRGFAVDAKGNVYVADKSNKAI 124
Cdd:COG4257   53 YPLGGGSGPHGIAV-DPDGNLWFTDNG----NNRIGRI--DPKTGEITTFALPGGGSNPHGIAFDPDGNLWFTDQGGNRI 125

                         90       100
                 ....*....|....*....|.
gi 332192325 125 RKIS-SSGSVTTIAGGISKAF 144
Cdd:COG4257  126 GRLDpATGEVTEFPLPTGGAG 146
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 58-150 3.71e-06

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 48.03  E-value: 3.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  58 VLDSSGSTFYTTsfplsvdsvinrfagdGSSGHvdgkaGNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTTIA 137
Cdd:cd14957   43 VFTSSGVYSYSI----------------GSGGT-----GSGQFNSPYGIAVDSNGNIYVADTDNNRIQVFNSSGVYQYSI 101

                         90
                 ....*....|...
gi 332192325 138 GGISKAFGHRDGP 150
Cdd:cd14957  102 GTGGSGDGQFNGP 114
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
45-187 4.75e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 47.71  E-value: 4.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  45 YTIHALPGSSNL---IVLDSSGSTFYTTSFplsvDSVINRFagDGSSGHVDGKAGNSRFSKPRGFAVDAKGNVYVADKSN 121
Cdd:COG4257   92 ITTFALPGGGSNphgIAFDPDGNLWFTDQG----GNRIGRL--DPATGEVTEFPLPTGGAGPYGIAVDPDGNLWVTDFGA 165

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 332192325 122 KAIRKIS-SSGSVTTIAggiskafghrdGPAQNATFSSdfeITFVPQ-RccLLVSDHGNEMIRQINLK 187
Cdd:COG4257  166 NAIGRIDpDTGTLTEYA-----------LPTPGAGPRG---LAVDPDgN--LWVADTGSGRIGRFDPK 217
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 58-182 5.48e-06

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 47.65  E-value: 5.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  58 VLDSSGSTFYTtsfplsvdsvinrFAGDGSsghvdgkaGNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGS-VTTI 136
Cdd:cd14957  184 VFTSSGTFQYT-------------FGSSGS--------GPGQFSDPYGIAVDSDGNIYVADTGNHRIQVFTSSGAyQYSI 242

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 332192325 137 AGGISkafghrdgpaQNATFSSDFEItFVPQRCCLLVSDHGNEMIR 182
Cdd:cd14957  243 GTSGS----------GNGQFNYPYGI-AVDNDGKIYVADSNNNRIQ 277
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 86-150 8.86e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 46.89  E-value: 8.86e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 332192325  86 GSSGHvdgkaGNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTTIAGGISKAFGHRDGP 150
Cdd:cd14956   97 GSSGS-----GPGQFNAPRGVAVDADGNLYVADFGNQRIQKFDPDGSFLRQWGGTGIEPGSFNYP 156
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 84-159 9.67e-06

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 46.88  E-value: 9.67e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 332192325  84 GDGSSGhvdgkAGNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTTIAGGISKAFGHRDGPAQNATFSSD 159
Cdd:cd14957    6 AFGSNG-----SGNGQFNTPRGIAVDSAGNIYVADTGNNRIQVFTSSGVYSYSIGSGGTGSGQFNSPYGIAVDSNG 76
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 57-184 1.62e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 46.12  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  57 IVLDSSGSTFYTtsfplsvDSVINR---FAGDGSSGHVDGK--AGNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSG 131
Cdd:cd14956   18 IAVDADDNVYVA-------DARNGRiqvFDKDGTFLRRFGTtgDGPGQFGRPRGLAVDKDGWLYVADYWGDRIQVFTLTG 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 332192325 132 SVTTIAGGISKAFGHRDGPaQNATFSSDfeitfvpqrCCLLVSDHGNEMIRQI 184
Cdd:cd14956   91 ELQTIGGSSGSGPGQFNAP-RGVAVDAD---------GNLYVADFGNQRIQKF 133
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 57-129 3.82e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 44.87  E-value: 3.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  57 IVLDSSGSTFYTtsfplsvDSVINR---FAGDG-------SSGHVDGKagnsrFSKPRGFAVDAKGNVYVADKSNKAIRK 126
Cdd:cd14955  209 IAVDSAGNVYVA-------DTGNNRiqkFDSSGtfitkwgSEGSGDGQ-----FNSPSGIAVDSAGNVYVADSGNNRIQK 276


                 ...
gi 332192325 127 ISS 129
Cdd:cd14955  277 FAP 279
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 51-127 4.29e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 44.62  E-value: 4.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  51 PGSSNLIVLDSSGSTFYTTSFPLSV-----------DSVINR---FAGDGSSGHVDGKAGNS--RFSKPRGFAVDAKGNV 114
Cdd:cd05819  177 PDGNFLTTFGSTGTGPGQFNYPTGIavdsdgniyvaDSGNNRvqvFDPDGAGFGGNGNFLGSdgQFNRPSGLAVDSDGNL 256

                         90
                 ....*....|...
gi 332192325 115 YVADKSNKAIRKI 127
Cdd:cd05819  257 YVADTGNNRIQVF 269
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 58-150 4.52e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 44.95  E-value: 4.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  58 VLDSSGSTFYTtsfplsvdsvinrFAGDGSsghvdgkaGNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTTIA 137
Cdd:cd14957   90 VFNSSGVYQYS-------------IGTGGS--------GDGQFNGPYGIAVDSNGNIYVADTGNHRIQVFTSSGTFSYSI 148

                         90
                 ....*....|...
gi 332192325 138 GGISKAFGHRDGP 150
Cdd:cd14957  149 GSGGTGPGQFNGP 161
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 83-125 1.73e-04

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 43.69  E-value: 1.73e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 332192325   83 AGDGSSGHVDGKAGNSRFSKPRGFAVDAKGNVYVADKSNKAIR 125
Cdd:PLN02919  841 AGTGKAGFKDGKALKAQLSEPAGLALGENGRLFVADTNNSLIR 883
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 96-131 2.18e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 42.65  E-value: 2.18e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 332192325  96 GNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSG 131
Cdd:cd14956    8 GPGQFKDPRGIAVDADDNVYVADARNGRIQVFDKDG 43
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 49-118 2.44e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 42.57  E-value: 2.44e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 332192325  49 ALPGSSNLIVLDSSGSTfyttsfplsvdsvINRFAGDGSSGHVDGKAGNS--RFSKPRGFAVDAKGNVYVAD 118
Cdd:cd14962  154 AVDRDGNLYVTDTMNFR-------------VQIFDADGKFLRSFGERGDGpgSFARPKGIAVDSEGNIYVVD 212
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 96-182 2.54e-04

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 42.26  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  96 GNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTtiaggisKAFGHRDGPAQNATFSSDFEITfvpQRCCLLVSD 175
Cdd:cd14961    6 WPGTLNNPTGVAVTPTGRVVVADDGNKRIQVFDSDGNCL-------QQFGPKGDAGQDIRYPLDVAVT---PDGHIVVTD 75


                 ....*..
gi 332192325 176 HGNEMIR 182
Cdd:cd14961   76 AGDRSVK 82
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 44-124 2.60e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 42.57  E-value: 2.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  44 PYTIHAlPGSSNLIVLDSSGSTFYttsfplsvdsVINRFAGDGssgHVDGKAGNSRFSKPRGFAVDAKGNVYVADKSNKA 123
Cdd:cd14962   14 PYGVAA-DGRGRIYVADTGRGAVF----------VFDLPNGKV---FVIGNAGPNRFVSPIGVAIDANGNLYVSDAELGK 79


                 .
gi 332192325 124 I 124
Cdd:cd14962   80 V 80
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 86-184 2.94e-04

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 42.15  E-value: 2.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  86 GSSGHVDGKagnsrFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTTIAGGISKAFGHRDGPAQNAtfssdfeitfV 165
Cdd:cd14954   14 GKEGSKDGE-----LCRPWGVAVDKDGRIIVADRSNNRVQVFDPDGKFLRKFGSYGSRDGQFDRPAGVA----------V 78

                         90
                 ....*....|....*....
gi 332192325 166 PQRCCLLVSDHGNEMIrQI 184
Cdd:cd14954   79 NSRGRIIVADKDNHRI-QV 96
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 54-149 5.43e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 41.42  E-value: 5.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  54 SNLIVLDSSGSTFYTTSfplSVDSVINRFAGDGssghvDGKAGNSR--------FSKPRGFAVDAKGNVYVADKSNKAIR 125
Cdd:COG3386  139 PNGIAFSPDGRTLYVAD---TGAGRIYRFDLDA-----DGTLGNRRvfadlpdgPGGPDGLAVDADGNLWVALWGGGGVV 210

                         90       100
                 ....*....|....*....|....*....
gi 332192325 126 KISSSGSVT-TIAGGISK----AFGHRDG 149
Cdd:COG3386  211 RFDPDGELLgRIELPERRptnvAFGGPDL 239
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 79-154 1.31e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 40.34  E-value: 1.31e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 332192325  79 INRFAGDGSSGHVDGK--AGNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTTIAGgiskAFGHRDGPAQNA 154
Cdd:cd14956  177 IQVFDNDGAFLRKWGGrgTGPGQFNYPYGIAIDPDGNVFVADFGNNRIQKFTADGTFLTSWG----SPGTGPGQFKNP 250
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 54-148 2.36e-03

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 39.17  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325   54 SNLIVLDSSGSTFYTTsfplsvDSVINR---FAGDGSSG-------HVDGKAGNSRfskPRGFAVDAKGNVYVADKSNKA 123
Cdd:pfam08450 136 SNGLAWSPDGRTLYFA------DSPARKiwaYDYDLDGGlisnrrvFADFKPGLGR---PDGMAVDAEGNVWVARWGGGK 206

                          90       100       110
                  ....*....|....*....|....*....|
gi 332192325  124 IRKISSSGSVTTI----AGGISK-AFGHRD 148
Cdd:pfam08450 207 VVRFDPDGKLLREielpAKRPTScAFGGPD 236
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 79-183 2.86e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 39.19  E-value: 2.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332192325  79 INRFAGDGSS----GHVDGKAGnsRFSKPRGFAVDAKGNVYVADKSNKAIRkisssgsVTTIAGGISKAFGHRDgpAQNA 154
Cdd:cd14956  130 IQKFDPDGSFlrqwGGTGIEPG--SFNYPRGVAVDPDGTLYVADTYNDRIQ-------VFDNDGAFLRKWGGRG--TGPG 198

                         90       100
                 ....*....|....*....|....*....
gi 332192325 155 TFSSDFEITFVPQRcCLLVSDHGNEMIRQ 183
Cdd:cd14956  199 QFNYPYGIAIDPDG-NVFVADFGNNRIQK 226
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 86-150 3.52e-03

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 39.07  E-value: 3.52e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 332192325  86 GSSGhvdgkAGNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTTIAGGISKAFGHRDGP 150
Cdd:cd14954  202 GSEG-----SGNGQFKRPRGVAVDDEGNIIVADSGNHRVQVFSPDGEFLCSFGTEGNGEGQFDRP 261
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 89-131 3.57e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 38.81  E-value: 3.57e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 332192325  89 GHVDGKAGnsRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSG 131
Cdd:cd14963   46 GGPGTGPG--EFKYPYGIAVDSDGNIYVADLYNGRIQVFDPDG 86
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 93-139 3.77e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 38.81  E-value: 3.77e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 332192325  93 GKAGNSRFSKPRGFAVDAKGNVYVADKSNKAIRKISSSGSVTTIAGG 139
Cdd:cd14963  187 SPDGKSGFVNPRGIAVDPDGNLYVVDNLSHRVYVFDEQGKELFTFGG 233
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 79-127 5.20e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 38.42  E-value: 5.20e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 332192325  79 INRFAGDGSSGHVDGKAG--NSRFSKPRGFAVDAKGNVYVADKSNKAIRKI 127
Cdd:cd14956  224 IQKFTADGTFLTSWGSPGtgPGQFKNPWGVVVDADGTVYVADSNNNRVQRF 274
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 101-136 6.82e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 37.96  E-value: 6.82e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 332192325 101 SKPRGFAVDAKGNVYVADKSNKAIRKISS-SGSVTTI 136
Cdd:cd14952   10 DGPGGVAVDAAGNVYVADSGNNRVLKLAAgSTTQTVL 46
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 145-189 9.37e-03

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 37.94  E-value: 9.37e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 332192325 145 GHRDGPAQNATFSSdfeitfvPQRCCLL------VSDHGNEMIRQINLKEE 189
Cdd:cd14951    7 GLKDGSFAEASFNE-------PQGLALLpgnilyVADTENHALRKIDLETG 50
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 103-126 9.60e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 37.57  E-value: 9.60e-03
                         10        20
                 ....*....|....*....|....
gi 332192325 103 PRGFAVDAKGNVYVADKSNKAIRK 126
Cdd:cd14952  180 PSGVAVDTAGNVYVTDHGNNRVLK 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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