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Conserved domains on  [gi|332189981|gb|AEE28102|]
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Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459648)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  30708253|10517866
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
460-534 9.29e-11

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


:

Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 58.64  E-value: 9.29e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 332189981 460 LYLIIHDYDRAEKYFKRAAKAEPADAEALNKYATFLWRaRNDIWRAEEtYLEAISADPTNSVYSANYAHFLWNTG 534
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLE-QGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELG 73
 
Name Accession Description Interval E-value
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
460-534 9.29e-11

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 58.64  E-value: 9.29e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 332189981 460 LYLIIHDYDRAEKYFKRAAKAEPADAEALNKYATFLWRaRNDIWRAEEtYLEAISADPTNSVYSANYAHFLWNTG 534
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLE-QGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELG 73
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 425-496 5.33e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 45.31  E-value: 5.33e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 332189981 425 EAEESMDYFKTEL---LYQTGLSQEPGNVLLLANYAQfLYLIIHDYDRAEKYFKRAAKAEPADAealnkYATFLW 496
Cdd:cd24142    6 KAEELLDQGNFELalkFLQRALELEPNNVEALELLGE-ILLELGDVEEAREVLLRAIELDPDGG-----YEKYLY 74
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 434-521 3.26e-04

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 42.32  E-value: 3.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332189981  434 KTELLYQTGLSQEPGNVLLLANYAQFLYliiH--DYDRAEKYFKRAAKA----EPADAealNKYATFLWRARNDIWRAEE 507
Cdd:TIGR02521  83 KAEDSFRRALTLNPNNGDVLNNYGTFLC---QqgKYEQAMQQFEQAIEDplypQPARS---LENAGLCALKAGDFDKAEK 156

                          90
                  ....*....|....
gi 332189981  508 TYLEAISADPTNSV 521
Cdd:TIGR02521 157 YLTRALQIDPQRPE 170
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 466-520 4.41e-04

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 38.86  E-value: 4.41e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 332189981  466 DYDRAEKYFKRAAKAE---PADAEALNKYATFLWRaRNDIWRAEETYLEAISADPTNS 520
Cdd:pfam13432  12 DYDDAAAALEAALARFpesPDAAAALLLLGLAALR-QGRLAEAAAAYRAALRAAPGDP 68
 
Name Accession Description Interval E-value
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
460-534 9.29e-11

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 58.64  E-value: 9.29e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 332189981 460 LYLIIHDYDRAEKYFKRAAKAEPADAEALNKYATFLWRaRNDIWRAEEtYLEAISADPTNSVYSANYAHFLWNTG 534
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLE-QGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELG 73
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 421-534 1.54e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 59.59  E-value: 1.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332189981 421 EARLEAEESMDYFKTELLYQTGLSQEPGNVLLLANYAQFLYLIIHDYDRAEKYFKRAAKAEPADAEALNKYAtFLWRARN 500
Cdd:COG5010   24 VEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLA-LLYSRSG 102

                         90       100       110
                 ....*....|....*....|....*....|....
gi 332189981 501 DIWRAEETYLEAISADPTNSVYSANYAHFLWNTG 534
Cdd:COG5010  103 DKDEAKEYYEKALALSPDNPNAYSNLAALLLSLG 136
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 431-534 1.66e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 59.05  E-value: 1.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332189981 431 DYFKTELLYQTGLSQEPGNVLLLANYAQfLYLIIHDYDRAEKYFKRAAKAEPADAEALNKYATFLWRARN-DiwRAEETY 509
Cdd:COG4783   19 DYDEAEALLEKALELDPDNPEAFALLGE-ILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDyD--EALALL 95

                         90       100
                 ....*....|....*....|....*
gi 332189981 510 LEAISADPTNSVYSANYAHFLWNTG 534
Cdd:COG4783   96 EKALKLDPEHPEAYLRLARAYRALG 120
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
431-534 2.60e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.79  E-value: 2.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332189981 431 DYFKTELLYQTGLSQEPGNVLLLANYAQfLYLIIHDYDRAEKYFKRAAKAEPADAEALNKYAtFLWRARNDIWRAEETYL 510
Cdd:COG0457   23 RYEEAIEDYEKALELDPDDAEALYNLGL-AYLRLGRYEEALADYEQALELDPDDAEALNNLG-LALQALGRYEEALEDYD 100

                         90       100
                 ....*....|....*....|....
gi 332189981 511 EAISADPTNSVYSANYAHFLWNTG 534
Cdd:COG0457  101 KALELDPDDAEALYNLGLALLELG 124
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 438-519 3.45e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 58.28  E-value: 3.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332189981 438 LYQTGLSQEPGNVLLLANYAQfLYLIIHDYDRAEKYFKRAAKAEPADAEALNKYATFLWRArNDIWRAEETYLEAISADP 517
Cdd:COG4783   60 LLHEALELDPDEPEARLNLGL-ALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRAL-GRPDEAIAALEKALELDP 137


                 ..
gi 332189981 518 TN 519
Cdd:COG4783  138 DD 139
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
431-534 7.01e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 59.64  E-value: 7.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332189981 431 DYFKTELLYQTGLSQEPGNVLLLANYAqFLYLIIHDYDRAEKYFKRAAKAEPADAEALNKYATfLWRARNDIWRAEETYL 510
Cdd:COG0457   57 RYEEALADYEQALELDPDDAEALNNLG-LALQALGRYEEALEDYDKALELDPDDAEALYNLGL-ALLELGRYDEAIEAYE 134

                         90       100
                 ....*....|....*....|....
gi 332189981 511 EAISADPTNSVYSANYAHFLWNTG 534
Cdd:COG0457  135 RALELDPDDADALYNLGIALEKLG 158
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 439-519 7.89e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 56.94  E-value: 7.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332189981 439 YQTGLSQEPGNVLLLANYAQfLYLIIHDYDRAEKYFKRAAKAEPADAEALNKYATFLWRARNDIwRAEETYLEAISADPT 518
Cdd:COG4235    6 LRQALAANPNDAEGWLLLGR-AYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTE-EAEELLERALALDPD 83


                 .
gi 332189981 519 N 519
Cdd:COG4235   84 N 84
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
431-517 4.63e-09

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 53.64  E-value: 4.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332189981 431 DYFKTELLYQTGLSQEPGNVLLLANYAQFlYLIIHDYDRAEKyFKRAAKAEPADAEALNKYATFLWRaRNDIWRAEETYL 510
Cdd:COG3063    7 DLEEAEEYYEKALELDPDNADALNNLGLL-LLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLE-LGDYDEALAYLE 83


                 ....*..
gi 332189981 511 EAISADP 517
Cdd:COG3063   84 RALELDP 90
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 431-517 6.56e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 54.97  E-value: 6.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332189981 431 DYFKTELLYQTGLSQEPGNVLLLANYAqFLYLIIHDYDRAEKYFKRAAKAEPADAEALNKYATFLWRArNDIWRAEETYL 510
Cdd:COG5010   69 DFEESLALLEQALQLDPNNPELYYNLA-LLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSL-GQDDEAKAALQ 146


                 ....*..
gi 332189981 511 EAISADP 517
Cdd:COG5010  147 RALGTSP 153
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 439-520 3.92e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 51.93  E-value: 3.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332189981 439 YQTGLSQEPGNVLLLANYAQfLYLIIHDYDRAEKYFKRAAKAEPADAEALNKYATFLWRaRNDIWRAEETYLEAISADPT 518
Cdd:COG4235   40 YEKALRLDPDNADALLDLAE-ALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQ-QGDYAEAIAAWQKLLALLPA 117


                 ..
gi 332189981 519 NS 520
Cdd:COG4235  118 DA 119
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 460-534 3.97e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.50  E-value: 3.97e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 332189981 460 LYLIIHDYDRAEKYFKRAAKAEPADAEALNKYAtFLWRARNDIWRAEETYLEAISADPTNSVYSANYAHFLWNTG 534
Cdd:COG4783   13 ALLLAGDYDEAEALLEKALELDPDNPEAFALLG-EILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAG 86
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 438-527 1.44e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.19  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332189981 438 LYQTGLSQEPGNVLLLANYAQfLYLIIHDYDRAEKYFKRAAKAEPADAEALNKYATfLWRARNDIWRAEETYLEAISADP 517
Cdd:COG2956   64 IHQKLLERDPDRAEALLELAQ-DYLKAGLLDRAEELLEKLLELDPDDAEALRLLAE-IYEQEGDWEKAIEVLERLLKLGP 141

                         90
                 ....*....|
gi 332189981 518 TNSVYSANYA 527
Cdd:COG2956  142 ENAHAYCELA 151
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
443-534 5.45e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 5.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332189981 443 LSQEPGNVLLLANYAqFLYLIIHDYDRAEKYFKRAAKAEPADAEALNKYATFLWRArNDIWRAEETYLEAISADPTNSVY 522
Cdd:COG0457    1 LELDPDDAEAYNNLG-LAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRL-GRYEEALADYEQALELDPDDAEA 78

                         90
                 ....*....|..
gi 332189981 523 SANYAHFLWNTG 534
Cdd:COG0457   79 LNNLGLALQALG 90
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 451-534 1.40e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.11  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332189981 451 LLLANYAQF-------LYLIIHDYDRAEKYFKRAAKAEPADAEALNKYATfLWRARNDIWRAEETYLEAISADPTNSVYS 523
Cdd:COG2956    1 LLLPVAAALgwyfkglNYLLNGQPDKAIDLLEEALELDPETVEAHLALGN-LYRRRGEYDRAIRIHQKLLERDPDRAEAL 79

                         90
                 ....*....|.
gi 332189981 524 ANYAHFLWNTG 534
Cdd:COG2956   80 LELAQDYLKAG 90
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 438-534 1.98e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 49.73  E-value: 1.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332189981 438 LYQTGLSQEPGNVLLLANYAQfLYLIIHDYDRAEKYFKRAAKAEPADAEALNKYATfLWRARNDIWRAEETYLEAISADP 517
Cdd:COG2956  132 VLERLLKLGPENAHAYCELAE-LYLEQGDYDEAIEALEKALKLDPDCARALLLLAE-LYLEQGDYEEAIAALERALEQDP 209

                         90
                 ....*....|....*..
gi 332189981 518 TNSVYSANYAHFLWNTG 534
Cdd:COG2956  210 DYLPALPRLAELYEKLG 226
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 425-496 5.33e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 45.31  E-value: 5.33e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 332189981 425 EAEESMDYFKTEL---LYQTGLSQEPGNVLLLANYAQfLYLIIHDYDRAEKYFKRAAKAEPADAealnkYATFLW 496
Cdd:cd24142    6 KAEELLDQGNFELalkFLQRALELEPNNVEALELLGE-ILLELGDVEEAREVLLRAIELDPDGG-----YEKYLY 74
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
438-530 7.80e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.61  E-value: 7.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332189981 438 LYQTGLSQEPGNVLLLANYAQfLYLIIHDYDRAEKYFKRAAKAEPADAEALNKYATFLWRArNDIWRAEETYLEAISADP 517
Cdd:COG0457   98 DYDKALELDPDDAEALYNLGL-ALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL-GRYEEALELLEKLEAAAL 175

                         90
                 ....*....|...
gi 332189981 518 TNSVYSANYAHFL 530
Cdd:COG0457  176 AALLAAALGEAAL 188
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 421-534 1.82e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.21  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332189981 421 EARLEAEESMDYFKTELLYQTGLSQEPGNVLLLANYAQFLYLIiHDYDRAEKYFKRAAKAEPADAEALNKYATFLwRARN 500
Cdd:COG3914   49 AALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQAL-GRYEEALALYRRALALNPDNAEALFNLGNLL-LALG 126

                         90       100       110
                 ....*....|....*....|....*....|....
gi 332189981 501 DIWRAEETYLEAISADPTNSVYSANYAHFLWNTG 534
Cdd:COG3914  127 RLEEALAALRRALALNPDFAEAYLNLGEALRRLG 160
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 434-521 3.26e-04

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 42.32  E-value: 3.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332189981  434 KTELLYQTGLSQEPGNVLLLANYAQFLYliiH--DYDRAEKYFKRAAKA----EPADAealNKYATFLWRARNDIWRAEE 507
Cdd:TIGR02521  83 KAEDSFRRALTLNPNNGDVLNNYGTFLC---QqgKYEQAMQQFEQAIEDplypQPARS---LENAGLCALKAGDFDKAEK 156

                          90
                  ....*....|....
gi 332189981  508 TYLEAISADPTNSV 521
Cdd:TIGR02521 157 YLTRALQIDPQRPE 170
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 466-520 4.41e-04

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 38.86  E-value: 4.41e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 332189981  466 DYDRAEKYFKRAAKAE---PADAEALNKYATFLWRaRNDIWRAEETYLEAISADPTNS 520
Cdd:pfam13432  12 DYDDAAAALEAALARFpesPDAAAALLLLGLAALR-QGRLAEAAAAYRAALRAAPGDP 68
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 436-487 1.20e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.22  E-value: 1.20e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 332189981 436 ELLYQTGLSQEPGNVLLLANYAqFLYLIIHDYDRAEKYFKRAAKAEPADAEA 487
Cdd:COG4235   71 EELLERALALDPDNPEALYLLG-LAAFQQGDYAEAIAAWQKLLALLPADAPA 121
TPR_19 pfam14559
Tetratricopeptide repeat;
438-492 1.22e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 37.56  E-value: 1.22e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 332189981  438 LYQTGLSQEPGNVLLLANYAQFLYLiIHDYDRAEKYFKRAAKAEPADAEALNKYA 492
Cdd:pfam14559  10 LLEQALAEDPDNAEARLGLAEALLA-LGRLDEAEALLAALPAADPDDPRYAALLA 63
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 431-534 1.82e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 1.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332189981  431 DYFKTELLYQTGLSQEPGNVLLLANYAqFLYLIIHDyDRAEKYFKRAAKAEPADAEALNKYATFLWRaRNDIWRAEETYL 510
Cdd:TIGR02917 785 DYDKAIKHYQTVVKKAPDNAVVLNNLA-WLYLELKD-PRALEYAERALKLAPNIPAILDTLGWLLVE-KGEADRALPLLR 861

                          90       100
                  ....*....|....*....|....
gi 332189981  511 EAISADPTNSVYSANYAHFLWNTG 534
Cdd:TIGR02917 862 KAVNIAPEAAAIRYHLALALLATG 885
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 466-531 2.80e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 39.92  E-value: 2.80e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 332189981 466 DYDRAEKYFKRAAKAEPADAEALNKYATFLwrARN-DIWRAEETYLEAISADPtnsvySANYAHFLW 531
Cdd:cd24142   15 NFELALKFLQRALELEPNNVEALELLGEIL--LELgDVEEAREVLLRAIELDP-----DGGYEKYLY 74
TPR_14 pfam13428
Tetratricopeptide repeat;
452-492 3.17e-03

Tetratricopeptide repeat;


Pssm-ID: 463874 [Multi-domain]  Cd Length: 44  Bit Score: 35.48  E-value: 3.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 332189981  452 LLANYAQfLYLIIHDYDRAEKYFKRAAKAEPADAEALNKYA 492
Cdd:pfam13428   3 ALLALAR-ALLALGDPDEALALLERALALDPDDPEAWLALA 42
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 438-516 3.21e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 3.21e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 332189981 438 LYQTGLSQEPGNVLLLANYAQfLYLIIHDYDRAEKYFKRAAKAEPADAEALNKYAtfLWRARNDIWRAEETYLEAISAD 516
Cdd:COG2956  200 ALERALEQDPDYLPALPRLAE-LYEKLGDPEEALELLRKALELDPSDDLLLALAD--LLERKEGLEAALALLERQLRRH 275
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 442-519 4.04e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 4.04e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 332189981  442 GLSQEPGNVLLLaNYAQFLYLIIHDYDRAEKYFKRAAKAEPADAEALNKYATfLWRARNDIWRAEETYLEAISADPTN 519
Cdd:TIGR02917 457 LEKKQPDNASLH-NLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLAR-IDIQEGNPDDAIQRFEKVLTIDPKN 532
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 469-537 6.39e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.91  E-value: 6.39e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 332189981 469 RAEKYFKRAAKAEPADAEALNKYAtFLWRARNDIWRAEETYLEAISADPTNSVYSANYAHFLWNTGGDE 537
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLG-RAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTE 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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