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Conserved domains on  [gi|332010017|gb|AED97400|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
22-333 1.19e-44

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.38  E-value: 1.19e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017  22 HESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFevpkvkqmisgDTQARPLIRTFYDHAEPINDLDFHPRSTILIS 101
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW-----------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017 102 SAKDNCIKFFDFSKTTAKRAFKVfqDTHNVRSISFHPSGEFLLAGTDHPIPHLYDVNTYQCFLPSNFPDSGVSGainqVR 181
Cdd:COG2319  180 GSDDGTVRLWDLATGKLLRTLTG--HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRS----VA 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017 182 YSSTGSIYITASKDGAIRLFDGVSAKCVRSIGnaHGKSEVTSAVFTKDQRFVLSSGKDSTVKLWEIGSGRMVKEYLGakR 261
Cdd:COG2319  254 FSPDGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG--H 329

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 332010017 262 VKLRSQAIFNDTEEFVISideAS--NEVVTWDARTADKVAKWpSNHNGAPRWIEHSPVESVFVTCGIDRSIRFW 333
Cdd:COG2319  330 TGAVRSVAFSPDGKTLAS---GSddGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
22-333 1.19e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.38  E-value: 1.19e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017  22 HESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFevpkvkqmisgDTQARPLIRTFYDHAEPINDLDFHPRSTILIS 101
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW-----------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017 102 SAKDNCIKFFDFSKTTAKRAFKVfqDTHNVRSISFHPSGEFLLAGTDHPIPHLYDVNTYQCFLPSNFPDSGVSGainqVR 181
Cdd:COG2319  180 GSDDGTVRLWDLATGKLLRTLTG--HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRS----VA 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017 182 YSSTGSIYITASKDGAIRLFDGVSAKCVRSIGnaHGKSEVTSAVFTKDQRFVLSSGKDSTVKLWEIGSGRMVKEYLGakR 261
Cdd:COG2319  254 FSPDGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG--H 329

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 332010017 262 VKLRSQAIFNDTEEFVISideAS--NEVVTWDARTADKVAKWpSNHNGAPRWIEHSPVESVFVTCGIDRSIRFW 333
Cdd:COG2319  330 TGAVRSVAFSPDGKTLAS---GSddGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 23-334 3.30e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 153.26  E-value: 3.30e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017  23 ESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFevpkvkqmisgDTQARPLIRTFYDHAEPINDLDFHPRSTILISS 102
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW-----------DLETGELLRTLKGHTGPVRDVAASADGTYLASG 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017 103 AKDNCIKFFDFSKTTAKRAFKvfQDTHNVRSISFHPSGEFLLAGTDHPIPHLYDVNTYQCFlpSNFPdsGVSGAINQVRY 182
Cdd:cd00200   70 SSDKTIRLWDLETGECVRTLT--GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL--TTLR--GHTDWVNSVAF 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017 183 SSTGSIYITASKDGAIRLFDGVSAKCVRSIgNAHgKSEVTSAVFTKDQRFVLSSGKDSTVKLWEIGSGRMVKEYLGaKRV 262
Cdd:cd00200  144 SPDGTFVASSSQDGTIKLWDLRTGKCVATL-TGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-HEN 220

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 332010017 263 KLRSqAIFNDTEEFVISIDEASNeVVTWDARTADKVAKWPSnHNGAPRWIEHSPVESVFVTCGIDRSIRFWK 334
Cdd:cd00200  221 GVNS-VAFSPDGYLLASGSEDGT-IRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 20-59 4.99e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 4.99e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 332010017    20 PKHESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFE 59
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
25-59 1.14e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.14e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 332010017   25 KTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFE 59
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 86-247 2.76e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.49  E-value: 2.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017  86 PINDLDFHP-RSTILISSAKDNCIKFFD-----FSKTTAKRAFKVFQDTHNVRSISFHPSGEFLLA--GTDHPIpHLYDV 157
Cdd:PTZ00421  77 PIIDVAFNPfDPQKLFTASEDGTIMGWGipeegLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLAsaGADMVV-NVWDV 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017 158 NTyqcflpsnfpdsGVSGA--------INQVRYSSTGSIYITASKDGAIRLFDGVSAKCVRSIGnAHGKSEVTSAVFTKD 229
Cdd:PTZ00421 156 ER------------GKAVEvikchsdqITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKR 222

                        170       180
                 ....*....|....*....|..
gi 332010017 230 QRFVLSSG----KDSTVKLWEI 247
Cdd:PTZ00421 223 KDLIITLGcsksQQRQIMLWDT 244
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
22-333 1.19e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.38  E-value: 1.19e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017  22 HESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFevpkvkqmisgDTQARPLIRTFYDHAEPINDLDFHPRSTILIS 101
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW-----------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017 102 SAKDNCIKFFDFSKTTAKRAFKVfqDTHNVRSISFHPSGEFLLAGTDHPIPHLYDVNTYQCFLPSNFPDSGVSGainqVR 181
Cdd:COG2319  180 GSDDGTVRLWDLATGKLLRTLTG--HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRS----VA 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017 182 YSSTGSIYITASKDGAIRLFDGVSAKCVRSIGnaHGKSEVTSAVFTKDQRFVLSSGKDSTVKLWEIGSGRMVKEYLGakR 261
Cdd:COG2319  254 FSPDGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG--H 329

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 332010017 262 VKLRSQAIFNDTEEFVISideAS--NEVVTWDARTADKVAKWpSNHNGAPRWIEHSPVESVFVTCGIDRSIRFW 333
Cdd:COG2319  330 TGAVRSVAFSPDGKTLAS---GSddGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 23-334 3.30e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 153.26  E-value: 3.30e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017  23 ESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFevpkvkqmisgDTQARPLIRTFYDHAEPINDLDFHPRSTILISS 102
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW-----------DLETGELLRTLKGHTGPVRDVAASADGTYLASG 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017 103 AKDNCIKFFDFSKTTAKRAFKvfQDTHNVRSISFHPSGEFLLAGTDHPIPHLYDVNTYQCFlpSNFPdsGVSGAINQVRY 182
Cdd:cd00200   70 SSDKTIRLWDLETGECVRTLT--GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL--TTLR--GHTDWVNSVAF 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017 183 SSTGSIYITASKDGAIRLFDGVSAKCVRSIgNAHgKSEVTSAVFTKDQRFVLSSGKDSTVKLWEIGSGRMVKEYLGaKRV 262
Cdd:cd00200  144 SPDGTFVASSSQDGTIKLWDLRTGKCVATL-TGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-HEN 220

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 332010017 263 KLRSqAIFNDTEEFVISIDEASNeVVTWDARTADKVAKWPSnHNGAPRWIEHSPVESVFVTCGIDRSIRFWK 334
Cdd:cd00200  221 GVNS-VAFSPDGYLLASGSEDGT-IRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
25-249 1.17e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.19  E-value: 1.17e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017  25 KTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFevpkvkqmisgDTQARPLIRTFYDHAEPINDLDFHPRSTILISSAK 104
Cdd:COG2319  198 RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW-----------DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017 105 DNCIKFFDFSKTTAKRAFKvfQDTHNVRSISFHPSGEFLLAGTDHPIPHLYDVNTYQCFlpsnFPDSGVSGAINQVRYSS 184
Cdd:COG2319  267 DGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL----RTLTGHTGAVRSVAFSP 340

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 332010017 185 TGSIYITASKDGAIRLFDGVSAKCVRSIgNAHGkSEVTSAVFTKDQRFVLSSGKDSTVKLWEIGS 249
Cdd:COG2319  341 DGKTLASGSDDGTVRLWDLATGELLRTL-TGHT-GAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
23-333 2.72e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.04  E-value: 2.72e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017  23 ESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFevpkvkqmisgDTQARPLIRTFYDHAEPINDLDFHPRSTILISS 102
Cdd:COG2319   70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW-----------DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASG 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017 103 AKDNCIKFFDFSKTTAKRAFKVFQDThnVRSISFHPSGEFLL-AGTDHPIpHLYDVNTYQCFLPSnfpdSGVSGAINQVR 181
Cdd:COG2319  139 SADGTVRLWDLATGKLLRTLTGHSGA--VTSVAFSPDGKLLAsGSDDGTV-RLWDLATGKLLRTL----TGHTGAVRSVA 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017 182 YSSTGSIYITASKDGAIRLFDGVSAKCVRSIGnaHGKSEVTSAVFTKDQRFVLSSGKDSTVKLWEIGSGRMVKEYLGAK- 260
Cdd:COG2319  212 FSPDGKLLASGSADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSg 289

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 332010017 261 RVklrSQAIFNDTEEFVISIDEaSNEVVTWDARTAdKVAKWPSNHNGAPRWIEHSPVESVFVTCGIDRSIRFW 333
Cdd:COG2319  290 GV---NSVAFSPDGKLLASGSD-DGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-246 5.28e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.90  E-value: 5.28e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017  22 HESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFEVPKVKQmisgdtqarplIRTFYDHAEPINDLDFHPRSTILIS 101
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC-----------LTTLRGHTDWVNSVAFSPDGTFVAS 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017 102 SAKDNCIKFFDFSKTTAKRAFKVFQDthNVRSISFHPSGE-FLLAGTDHPIpHLYDVNTYQCF--LpsnfpdSGVSGAIN 178
Cdd:cd00200  153 SSQDGTIKLWDLRTGKCVATLTGHTG--EVNSVAFSPDGEkLLSSSSDGTI-KLWDLSTGKCLgtL------RGHENGVN 223

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 332010017 179 QVRYSSTGSIYITASKDGAIRLFDGVSAKCVRSIGnAHgKSEVTSAVFTKDQRFVLSSGKDSTVKLWE 246
Cdd:cd00200  224 SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS-GH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 21-112 4.99e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.66  E-value: 4.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017  21 KHESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFevpkvkqmisgDTQARPLIRTFYDHAEPINDLDFHPRSTILI 100
Cdd:cd00200  209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW-----------DLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                         90
                 ....*....|..
gi 332010017 101 SSAKDNCIKFFD 112
Cdd:cd00200  278 SGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 20-59 4.99e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 4.99e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 332010017    20 PKHESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFE 59
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 76-112 7.76e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 7.76e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 332010017    76 LIRTFYDHAEPINDLDFHPRSTILISSAKDNCIKFFD 112
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
25-59 1.14e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.14e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 332010017   25 KTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFE 59
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
76-112 3.87e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.87e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 332010017   76 LIRTFYDHAEPINDLDFHPRSTILISSAKDNCIKFFD 112
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 25-247 5.07e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 44.68  E-value: 5.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017   25 KTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFEVPKVKqmiSGDTQARPLIRTFYDHAEPINDLDFH----------- 93
Cdd:pfam20426 118 QSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGR---SSEKRSRNTQTEFPRKDHVIAETPFHilcghddiitc 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017   94 ----PRSTILISSAKD-NCIkffdfskttakraFKVFQDTHNVRSISfHPSGEFL--LAGTDHPIP----------HLYD 156
Cdd:pfam20426 195 lyvsVELDIVISGSKDgTCI-------------FHTLREGRYVRSIR-HPSGCPLskLVASRHGRIvlyadddlslHLYS 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017  157 VNTYQcfLPSnfpdSGVSGAINQVRYSSTGSIYITASKDGAIRLFDGVSAKCVRSIGNAhGKSeVTSAVFTKDQRFvLSS 236
Cdd:pfam20426 261 INGKH--IAS----SESNGRLNCIELSSCGEFLVCAGDQGQIVVRSMNSLEVVRRYNGI-GKI-ITSLTVTPEECF-LAG 331

                         250
                  ....*....|.
gi 332010017  237 GKDSTVKLWEI 247
Cdd:pfam20426 332 TKDGSLLVYSI 342
WD40 COG2319
WD40 repeat [General function prediction only];
23-61 1.46e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 1.46e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 332010017  23 ESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFEVP 61
Cdd:COG2319  364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
PTZ00421 PTZ00421
coronin; Provisional
 86-247 2.76e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.49  E-value: 2.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017  86 PINDLDFHP-RSTILISSAKDNCIKFFD-----FSKTTAKRAFKVFQDTHNVRSISFHPSGEFLLA--GTDHPIpHLYDV 157
Cdd:PTZ00421  77 PIIDVAFNPfDPQKLFTASEDGTIMGWGipeegLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLAsaGADMVV-NVWDV 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332010017 158 NTyqcflpsnfpdsGVSGA--------INQVRYSSTGSIYITASKDGAIRLFDGVSAKCVRSIGnAHGKSEVTSAVFTKD 229
Cdd:PTZ00421 156 ER------------GKAVEvikchsdqITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKR 222

                        170       180
                 ....*....|....*....|..
gi 332010017 230 QRFVLSSG----KDSTVKLWEI 247
Cdd:PTZ00421 223 KDLIITLGcsksQQRQIMLWDT 244
WD40 pfam00400
WD domain, G-beta repeat;
207-246 4.71e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 4.71e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 332010017  207 KCVRSIgNAHgKSEVTSAVFTKDQRFVLSSGKDSTVKLWE 246
Cdd:pfam00400   2 KLLKTL-EGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 205-246 4.92e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 4.92e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 332010017   205 SAKCVRSIgNAHgKSEVTSAVFTKDQRFVLSSGKDSTVKLWE 246
Cdd:smart00320   1 SGELLKTL-KGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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