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Conserved domains on  [gi|332007451|gb|AED94834|]
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marneral synthase [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLN03012 super family cl31551
Camelliol C synthase
1-752 0e+00

Camelliol C synthase


The actual alignment was detected with superfamily member PLN03012:

Pssm-ID: 166653 [Multi-domain]  Cd Length: 759  Bit Score: 1074.26  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451   1 MWRLRIGAEARQDPHLFTTNNFAGRQIWEFDANGGSPEELAEVEEARLNFANNKSRFKASPDLFWRRQFLREKKFEQKIP 80
Cdd:PLN03012   1 MWKLKIAEGNGDDPYLFSTNNFAGRQTWEFDPDAGSPEELAAVEEARRIFYDDRFHVKASSDLIWRMQFLKEKKFEQRIA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  81 RVRIEDAEKITYEDAKTALRRGVLYYAACQANDGHWPSEVSGSMFLDAPFVICLYITGHLEKIFTLEHVKELLRYMYNTQ 160
Cdd:PLN03012  81 PAKVEDAEKITFEIATNALRKGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEIFTQDHRKEILRYIYCHQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 161 NEDGGWGLDVESHSVMFCTVLNYICLRILGVEPDhDGQKSACARARKWILDHGGATYAPMVAKAWLSVLGVYDWSGCKPL 240
Cdd:PLN03012 161 KEDGGWGLHIEGHSTMFCTTLNYICMRILGEGPD-GGHDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPM 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 241 PPEIWMLPSFSPINGGTLWIYIRDLLMGMSYLYGKKFVATPTALILQLREELYPQPYSKIIWSKARNRCAKEDLLYPKSF 320
Cdd:PLN03012 240 PPEFWILPSFFPIHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPL 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 321 GQDLFWEGVHMLSENIINRWPLNKFVRQRALRTTMELVHYHDETTHYITGACVAKPFHMLACWVEDPDGDYFKKHLARVP 400
Cdd:PLN03012 320 IQDLIWDCLYIFAEPFLACWPFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGDHFKKHLLRIS 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 401 DFIWIAEDGLKFQLMGMQSWNAALSLQVMLAANMDDEIRSTLIKGYDFLKQSQISENPQGDHLKMFRDITKGGWTFQDRE 480
Cdd:PLN03012 400 DYLWIAEDGMKMQSFGSQLWDSGFALQALLASNLSNEIPDVLRRGHDFIKNSQVGENPSGDFKNMYRHISKGAWTFSDRD 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 481 QGLPISDGTAESIECCIHFHRMPSEFIGEKMDVEKLYDAVNFLIYLQSDNGGMPVWEPAPGKKWLEWLSPVEHVENTVVE 560
Cdd:PLN03012 480 HGWQASDCTAEGFKCCLLFSMIAPDIVGPKMDPEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIE 559
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 561 QEYLECTGSVIAGLVCFKKEFPDHRPKEIEKLIKKGLKYIEDLQMPDGSWYGNWGVCFTYGTLFAVRGLAAAGKTFGNSE 640
Cdd:PLN03012 560 HEYNECTSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFNDCE 639
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 641 AIRRAVQFILNTQNAEGGWGESALSCPNKKYIPSKGNVTNVVNTGQAMMVLLIGGQMERDPSPVHRAAKVLINSQLDIGD 720
Cdd:PLN03012 640 AIRKGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEGEISNLVQTAWALMGLIHAGQAERDPIPLHRAAKLIINSQLENGD 719
                        730       740       750
                 ....*....|....*....|....*....|...
gi 332007451 721 FPQQERRGIYM-NMLLHYPTYRNMFSLWALALY 752
Cdd:PLN03012 720 FPQQEATGAFLkNCLLHYAAYRNIFPLWALAEY 752
 
Name Accession Description Interval E-value
PLN03012 PLN03012
Camelliol C synthase
1-752 0e+00

Camelliol C synthase


Pssm-ID: 166653 [Multi-domain]  Cd Length: 759  Bit Score: 1074.26  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451   1 MWRLRIGAEARQDPHLFTTNNFAGRQIWEFDANGGSPEELAEVEEARLNFANNKSRFKASPDLFWRRQFLREKKFEQKIP 80
Cdd:PLN03012   1 MWKLKIAEGNGDDPYLFSTNNFAGRQTWEFDPDAGSPEELAAVEEARRIFYDDRFHVKASSDLIWRMQFLKEKKFEQRIA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  81 RVRIEDAEKITYEDAKTALRRGVLYYAACQANDGHWPSEVSGSMFLDAPFVICLYITGHLEKIFTLEHVKELLRYMYNTQ 160
Cdd:PLN03012  81 PAKVEDAEKITFEIATNALRKGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEIFTQDHRKEILRYIYCHQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 161 NEDGGWGLDVESHSVMFCTVLNYICLRILGVEPDhDGQKSACARARKWILDHGGATYAPMVAKAWLSVLGVYDWSGCKPL 240
Cdd:PLN03012 161 KEDGGWGLHIEGHSTMFCTTLNYICMRILGEGPD-GGHDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPM 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 241 PPEIWMLPSFSPINGGTLWIYIRDLLMGMSYLYGKKFVATPTALILQLREELYPQPYSKIIWSKARNRCAKEDLLYPKSF 320
Cdd:PLN03012 240 PPEFWILPSFFPIHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPL 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 321 GQDLFWEGVHMLSENIINRWPLNKFVRQRALRTTMELVHYHDETTHYITGACVAKPFHMLACWVEDPDGDYFKKHLARVP 400
Cdd:PLN03012 320 IQDLIWDCLYIFAEPFLACWPFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGDHFKKHLLRIS 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 401 DFIWIAEDGLKFQLMGMQSWNAALSLQVMLAANMDDEIRSTLIKGYDFLKQSQISENPQGDHLKMFRDITKGGWTFQDRE 480
Cdd:PLN03012 400 DYLWIAEDGMKMQSFGSQLWDSGFALQALLASNLSNEIPDVLRRGHDFIKNSQVGENPSGDFKNMYRHISKGAWTFSDRD 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 481 QGLPISDGTAESIECCIHFHRMPSEFIGEKMDVEKLYDAVNFLIYLQSDNGGMPVWEPAPGKKWLEWLSPVEHVENTVVE 560
Cdd:PLN03012 480 HGWQASDCTAEGFKCCLLFSMIAPDIVGPKMDPEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIE 559
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 561 QEYLECTGSVIAGLVCFKKEFPDHRPKEIEKLIKKGLKYIEDLQMPDGSWYGNWGVCFTYGTLFAVRGLAAAGKTFGNSE 640
Cdd:PLN03012 560 HEYNECTSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFNDCE 639
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 641 AIRRAVQFILNTQNAEGGWGESALSCPNKKYIPSKGNVTNVVNTGQAMMVLLIGGQMERDPSPVHRAAKVLINSQLDIGD 720
Cdd:PLN03012 640 AIRKGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEGEISNLVQTAWALMGLIHAGQAERDPIPLHRAAKLIINSQLENGD 719
                        730       740       750
                 ....*....|....*....|....*....|...
gi 332007451 721 FPQQERRGIYM-NMLLHYPTYRNMFSLWALALY 752
Cdd:PLN03012 720 FPQQEATGAFLkNCLLHYAAYRNIFPLWALAEY 752
SQCY_1 cd02892
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ...
99-752 0e+00

Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.


Pssm-ID: 239222 [Multi-domain]  Cd Length: 634  Bit Score: 797.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  99 LRRGVLYYAACQANDGHWPSEVSGSMFLDAPFVICLYITGHlekIFTLEHVKELLRYMYNTQNEDGGWGLDVESHSVMFC 178
Cdd:cd02892    1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGI---PIDPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 179 TVLNYICLRILGVEPDHDgqksACARARKWILDHGGATYAPMVAKAWLSVLGVYDWSGCKPLPPEIWMLPSFSPINGGTL 258
Cdd:cd02892   78 TVLNYVALRLLGVSPDDP----HMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKF 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 259 WIYIRDLLMGMSYLYGKKFVATPTALILQLREELYPQPYSKIIWSKARNrcakeDLLYPKSFGQDLFWEGVHMLSEniiN 338
Cdd:cd02892  154 WCWARTVYVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRN-----DLYDYRPPWQRLFDALDRLLHW---Y 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 339 RWPLNKFVRQRALRTTMELVHYHDETTHYITGACVAKPFHMLACWVED-PDGDYFKKHLARVPDFIWIAEDGLKF-QLMG 416
Cdd:cd02892  226 EPLPPKPLRRKALRKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGyPDSPAFKRHLERIDDFLWLGPEGMKMcQTNG 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 417 MQSWNAALSLQVMLAANMDDEIRSTLIKGYDFLKQSQIsENPQGDHLKMFRDITKGGWTFQDREQGLPISDGTAESIECC 496
Cdd:cd02892  306 SQVWDTALAVQALLEAGLAPEFDPALKKALDWLLESQI-LDNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKAL 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 497 IHFHRMPSEfiGEKMDVEKLYDAVNFLIYLQSDNGGMPVWEPAPGKKWLEWLSPVEHVENTVVEQEYLECTGSVIAGLVC 576
Cdd:cd02892  385 LRLQELPPF--GEKVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGL 462
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 577 FKKEFPDHRpKEIEKLIKKGLKYIEDLQMPDGSWYGNWGVCFTYGTLFAVRGLAAAGKTFGNSEAIRRAVQFILNTQNAE 656
Cdd:cd02892  463 FGKLYPGHR-REIDPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYENSPYIRKACDFLLSKQNPD 541
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 657 GGWGESALSCPNKKYIPSKGnvTNVVNTGQAMMVLLIGGQMERDpsPVHRAAKVLINSQLDIGDFPQQERRGIYM-NMLL 735
Cdd:cd02892  542 GGWGESYLSYEDKSYAGGGR--STVVQTAWALLALMAAGEPDSE--AVERGIKYLLNTQLPDGDWPQEEITGVGFpNFYI 617
                        650
                 ....*....|....*..
gi 332007451 736 HYPTYRNMFSLWALALY 752
Cdd:cd02892  618 RYHNYRNYFPLWALGRY 634
squalene_cyclas TIGR01787
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ...
98-754 0e+00

squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.


Pssm-ID: 273809 [Multi-domain]  Cd Length: 621  Bit Score: 592.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451   98 ALRRGVLYYAACQANDGHWPSEVSGSMFLDAPFVICLYITGhlekIFTLEHVKELLRYMYNTQNEDGGWGLDVESHSVMF 177
Cdd:TIGR01787   1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIAD----TPLPGYREKIVRYLRHHQNEDGGWGLHIGGKSTVF 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  178 CTVLNYICLRILGVEPDHDgqksACARARKWILDHGGATYAPMVAKAWLSVLGVYDWSGCKPLPPEIWMLPSFSPINGGT 257
Cdd:TIGR01787  77 GTVLAYVALKILGMSPDDP----AMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSK 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  258 LWIYIRDLLMGMSYLYGKKFVATptaliLQLREELYPQPYSKiiwSKARNRCAKEDLLYPKSFGQDLFWegvhmLSENII 337
Cdd:TIGR01787 153 SWCRCRMVYLPMSYCYGERLSAP-----IDPREELYVEDDSI---RAQRNNVAKEDLYTPHSWLLRALY-----GLLNLF 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  338 NRWPLNKFVRQRALRTTMELVHYHDetthyiTGACVAKPFHMLACWVED-PDGDYFKKHLARVPDFIWIAEDGLKFQLMG 416
Cdd:TIGR01787 220 YHPFLRKALRKRALQWLYEHIAADG------SIGPISKAMAMLALWFLDgPNSPAFQKHLQRIDDYLWLQLDGMKMQGTG 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  417 MQSWNAALSLQVMLAANMD--DEIRSTLIKGYDFLKQSQISENPQGDHlKMFRDITK-GGWTFQDREQGLPI-SDGTAES 492
Cdd:TIGR01787 294 SQVWDTAFAIQALRESGDHrlPEFHPALVKAHEWLLLSQIPDNPPGDW-KVYRHNLKpGGWAFSFLNCGYPDvDDTAVVA 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  493 IECCIHFHRMpsefigEKMDVEKLYDAVNFLIYLQSDNGGMPVWEPAPGKKWLEWLSPVEHVENTVVEQEYLECTGSVIA 572
Cdd:TIGR01787 373 LKAVLLLQED------EHVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQ 446
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  573 GLVCFKkefpdHRPKEIEKLIKKGLKYIEDLQMPDGSWYGNWGVCFTYGTLFAVRGLAAAGKTFGNSEAIRRAVQFILNT 652
Cdd:TIGR01787 447 ALGAFG-----HRADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRNCPEVQKACDWLLSR 521
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  653 QNAEGGWGESALSCPNKKYIPSKGnvTNVVNTGQAMMVLLIGGQMERDpsPVHRAAKVLINSQLDIGDFPQQERRGIYM- 731
Cdd:TIGR01787 522 QMPDGGWGEDCFSYEDPSYVGSGG--STPSQTGWALMALIAAGEADSE--AIERGVKYLLETQRPDGDWPQEYITGVGFp 597
                         650       660
                  ....*....|....*....|....
gi 332007451  732 -NMLLHYPTYRNMFSLWALALYTN 754
Cdd:TIGR01787 598 kNFYLKYTNYRNIFPLWALGRYRQ 621
SqhC COG1657
Terpene cyclase SqhC [Lipid transport and metabolism];
76-757 9.53e-128

Terpene cyclase SqhC [Lipid transport and metabolism];


Pssm-ID: 441263 [Multi-domain]  Cd Length: 644  Bit Score: 394.96  E-value: 9.53e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  76 EQKIPRVRIEDAEKITYEDAKTALRRGVLYYAAcQANDGHWPSEVSGSMFLDAPFVICLYitgHLEKIFTLEHVKELLRY 155
Cdd:COG1657    2 IAPASASASSASNAEDRSLLDAAIAAAQALLLQ-QQDDGGWWGGELEADVTIAAEYILLH---HFLGPDDEELEAKIARY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 156 MYNTQNEDGGWGLDVESHSVMFCTVLNYICLRILGVEPDHdgqkSACARARKWILDHGGATYAPMVAKAWLSVLGVYDWS 235
Cdd:COG1657   78 LRRQQNDDGGWPLYHGGPGDLSTTVKAYFALKLLGDDPDA----PHMVRAREFILARGGAARANVFTKIWLALFGQYPWR 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 236 GCKPLPPEIWMLPSFSPINGGTLWIYIRDLLMGMSYLYGKKFVATPTALIlqLREELYPQPYSKIiwskarnrcakedLL 315
Cdd:COG1657  154 GVPALPPEIMLLPRWFPFHIYKFSYWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQV-------------DY 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 316 YPKSFGQDLFWEGVHMLSENIINRW-PLN-KFVRQRALRTTMELVHYHDE-TTHYIT-GACVAKPFHMLACWVEDPDGDY 391
Cdd:COG1657  219 YFPAPRDRSPWSRFFLALDRLLRAYeRLPpKPLRRRALRKAEDWILERLEgDGGLGGiFPAMVNSLMALLALGYPPDHPV 298
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 392 FKKHLARVPDFIWIAEDGLKFQLMGMQSWNAALSLQVMLAANMdDEIRSTLIKGYDFLKQSQISEnpQGDHLKMFRDITK 471
Cdd:COG1657  299 VRRALEALEKLLVETEDGARCQPCVSPVWDTALAVQALQEAGL-PEDHPALERAADWLLSKQILV--KGDWAVKRPDVEP 375
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 472 GGWTFQDREQGLPISDGTAESIECCIHFHRMPSEFIGEKMDveklyDAVNFLIYLQSDNGGMPVWEPAPGKKWLEWLSPV 551
Cdd:COG1657  376 GGWAFQFANDHYPDVDDTAVVLMALLRLRLPDEPRYREAIE-----RAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFA 450
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 552 EHveNTVVEQEYLECTGSVIAGLVCFkkefpdhRPKEIEKLIKKGLKYIEDLQMPDGSWYGNWGVCFTYGTLFAVRGLAA 631
Cdd:COG1657  451 DH--GALLDPPTADVTARCLEMLGQL-------GLTEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNA 521
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 632 AGKTfGNSEAIRRAVQFILNTQNAEGGWGESALSCPNKKYIPSKgnVTNVVNTGQAMMVLLIGGqmERDPSPVHRAAKVL 711
Cdd:COG1657  522 AGVD-PDDPAIRRAVAWLLSIQNADGGWGEDCRSYEDPRYVGLG--PSTASQTAWALLALLAAG--EADSPAVARGIAYL 596
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*...
gi 332007451 712 INSQLDIGDFPQQERRGIYMN--MLLHYPTYRNMFSLWALALYTNALR 757
Cdd:COG1657  597 LSTQREDGSWDEEYFTGTGFPrvFYLRYHLYRQYFPLWALARYRNLRG 644
SQHop_cyclase_N pfam13249
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ...
110-352 5.03e-31

Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.


Pssm-ID: 433061 [Multi-domain]  Cd Length: 290  Bit Score: 123.36  E-value: 5.03e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  110 QANDGHWPSEVSGSMFLDAPFVICLYITGHLEKifTLEHvkELLRYMYNTQNEDGGWGLDVESHSVMFCTVLNYICLRIL 189
Cdd:pfam13249  12 QHPDGHWVGELEANVTITAEYILLRHFLGPDDP--ELEA--KIARYLRSQQREDGGWPLFHGGPGDLSTTVEAYFALKLL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  190 GVEPDHdgqkSACARARKWILDHGGATYAPMVAKAWLSVLGVYDWSGCKPLPPEIWMLPSFSPINggtlwIY-----IRD 264
Cdd:pfam13249  88 GDSPDA----PHMVRAREFILARGGAAKANVFTRIWLALFGQYPWRGVPSMPPEIMLLPRWFPFN-----IYkfsswART 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  265 LLMGMSYLYGKKFVA-TPTALILQlreELYPQPYSKIiwskaRNRCAKEDLLYPKsfgqDLFWEGVHMLSenIINRWPLn 343
Cdd:pfam13249 159 TIVPLLILSALKPVApLPPGIGLD---ELFVEPPENV-----RYYPRPHRLFSWT----NLFLGLDRVLK--LYERLPP- 223

                  ....*....
gi 332007451  344 KFVRQRALR 352
Cdd:pfam13249 224 KPLRRRALR 232
 
Name Accession Description Interval E-value
PLN03012 PLN03012
Camelliol C synthase
1-752 0e+00

Camelliol C synthase


Pssm-ID: 166653 [Multi-domain]  Cd Length: 759  Bit Score: 1074.26  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451   1 MWRLRIGAEARQDPHLFTTNNFAGRQIWEFDANGGSPEELAEVEEARLNFANNKSRFKASPDLFWRRQFLREKKFEQKIP 80
Cdd:PLN03012   1 MWKLKIAEGNGDDPYLFSTNNFAGRQTWEFDPDAGSPEELAAVEEARRIFYDDRFHVKASSDLIWRMQFLKEKKFEQRIA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  81 RVRIEDAEKITYEDAKTALRRGVLYYAACQANDGHWPSEVSGSMFLDAPFVICLYITGHLEKIFTLEHVKELLRYMYNTQ 160
Cdd:PLN03012  81 PAKVEDAEKITFEIATNALRKGIHFFSALQASDGHWPAENAGPLFFLPPLVFCLYITGHLDEIFTQDHRKEILRYIYCHQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 161 NEDGGWGLDVESHSVMFCTVLNYICLRILGVEPDhDGQKSACARARKWILDHGGATYAPMVAKAWLSVLGVYDWSGCKPL 240
Cdd:PLN03012 161 KEDGGWGLHIEGHSTMFCTTLNYICMRILGEGPD-GGHDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPM 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 241 PPEIWMLPSFSPINGGTLWIYIRDLLMGMSYLYGKKFVATPTALILQLREELYPQPYSKIIWSKARNRCAKEDLLYPKSF 320
Cdd:PLN03012 240 PPEFWILPSFFPIHPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPL 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 321 GQDLFWEGVHMLSENIINRWPLNKFVRQRALRTTMELVHYHDETTHYITGACVAKPFHMLACWVEDPDGDYFKKHLARVP 400
Cdd:PLN03012 320 IQDLIWDCLYIFAEPFLACWPFNKLLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACWVEDPNGDHFKKHLLRIS 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 401 DFIWIAEDGLKFQLMGMQSWNAALSLQVMLAANMDDEIRSTLIKGYDFLKQSQISENPQGDHLKMFRDITKGGWTFQDRE 480
Cdd:PLN03012 400 DYLWIAEDGMKMQSFGSQLWDSGFALQALLASNLSNEIPDVLRRGHDFIKNSQVGENPSGDFKNMYRHISKGAWTFSDRD 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 481 QGLPISDGTAESIECCIHFHRMPSEFIGEKMDVEKLYDAVNFLIYLQSDNGGMPVWEPAPGKKWLEWLSPVEHVENTVVE 560
Cdd:PLN03012 480 HGWQASDCTAEGFKCCLLFSMIAPDIVGPKMDPEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIE 559
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 561 QEYLECTGSVIAGLVCFKKEFPDHRPKEIEKLIKKGLKYIEDLQMPDGSWYGNWGVCFTYGTLFAVRGLAAAGKTFGNSE 640
Cdd:PLN03012 560 HEYNECTSSAIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFNDCE 639
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 641 AIRRAVQFILNTQNAEGGWGESALSCPNKKYIPSKGNVTNVVNTGQAMMVLLIGGQMERDPSPVHRAAKVLINSQLDIGD 720
Cdd:PLN03012 640 AIRKGVHFLLAAQKDNGGWGESYLSCPKKIYIAQEGEISNLVQTAWALMGLIHAGQAERDPIPLHRAAKLIINSQLENGD 719
                        730       740       750
                 ....*....|....*....|....*....|...
gi 332007451 721 FPQQERRGIYM-NMLLHYPTYRNMFSLWALALY 752
Cdd:PLN03012 720 FPQQEATGAFLkNCLLHYAAYRNIFPLWALAEY 752
PLN02993 PLN02993
lupeol synthase
1-755 0e+00

lupeol synthase


Pssm-ID: 215537 [Multi-domain]  Cd Length: 763  Bit Score: 1049.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451   1 MWRLRIGAEARQDPHLFTTNNFAGRQIWEFDANGGSPEELAEVEEARLNFANNKSRFKASPDLFWRRQFLREKKFEQKIP 80
Cdd:PLN02993   1 MWKLKIGEGNGEDPYLFSSNNFVGRQTWEFDPKAGTPEERAAVEEARRSFLDNRSRVKGCSDLLWRMQFLKEAKFEQVIP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  81 RVRIEDAEKITYEDAKTALRRGVLYYAACQANDGHWPSEVSGSMFLDAPFVICLYITGHLEKIFTLEHVKELLRYMYNTQ 160
Cdd:PLN02993  81 PVKIDRGEEITYETATNALRRGVSFFSALQASDGHWPGEITGPLFFLPPLVFCLYITGHLEEVFDAEHRKEMLRHIYCHQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 161 NEDGGWGLDVESHSVMFCTVLNYICLRILGVEPDhDGQKSACARARKWILDHGGATYAPMVAKAWLSVLGVYDWSGCKPL 240
Cdd:PLN02993 161 NEDGGWGLHIESKSVMFCTVLNYICLRMLGEGPN-GGRENACKRARQWILDHGGVTYIPSWGKFWLSILGIYDWSGTNPM 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 241 PPEIWMLPSFSPINGGTLWIYIRDLLMGMSYLYGKKFVATPTALILQLREELYPQPYSKIIWSKARNRCAKEDLLYPKSF 320
Cdd:PLN02993 240 PPEIWLLPSFLPIHLGKTLCYTRMVYMPMSYLYGKRFVGPITPLIMLLREELHLQPYEEINWNKARRLCAKEDMYYPHPL 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 321 GQDLFWEGVHMLSENIINRWPLNKFVRQRALRTTMELVHYHDETTHYITGACVAKPFHMLACWVEDPDGDYFKKHLARVP 400
Cdd:PLN02993 320 VQDLIWDTLHNFVEPFLTRWPLNKLVREKALQVAMKHIHYEDENSHYITIGCVEKVLCMLACWIENPNGDHFKKHLARIP 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 401 DFIWIAEDGLKFQLMGMQSWNAALSLQVMLAANMDDEIRSTLIKGYDFLKQSQISENPQGDHLKMFRDITKGGWTFQDRE 480
Cdd:PLN02993 400 DYMWVAEDGMKMQSFGSQLWDTGFAIQALLASDLSDETDDVLRRGHNYIKKSQVRENPSGDFKSMYRHISKGAWTLSDRD 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 481 QGLPISDGTAESIECCIHFHRMPSEFIGEKMDVEKLYDAVNFLIYLQSDNGGMPVWEPAPGKKWLEWLSPVEHVENTVVE 560
Cdd:PLN02993 480 HGWQVSDCTAEALKCCMLLSMMPADVVGQKIDPEQLYDSVNLLLSLQSENGGVTAWEPVRAYKWLELLNPTDFFANTMVE 559
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 561 QEYLECTGSVIAGLVCFKKEFPDHRPKEIEKLIKKGLKYIEDLQMPDGSWYGNWGVCFTYGTLFAVRGLAAAGKTFGNSE 640
Cdd:PLN02993 560 REYVECTSAVIQALVLFKQLYPDHRTKEIIKSIEKAVQFIESKQTPDGSWYGNWGICFIYATWFALGGLAAAGKTYNDCL 639
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 641 AIRRAVQFILNTQNAEGGWGESALSCPNKKYIPSKGNVTNVVNTGQAMMVLLIGGQMERDPSPVHRAAKVLINSQLDIGD 720
Cdd:PLN02993 640 AMRKGVHFLLTIQRDDGGWGESYLSCPEQRYIPLEGNRSNLVQTAWAMMGLIHAGQAERDLIPLHRAAKLIITSQLENGD 719
                        730       740       750
                 ....*....|....*....|....*....|....*.
gi 332007451 721 FPQQERRGIYMNM-LLHYPTYRNMFSLWALALYTNA 755
Cdd:PLN02993 720 FPQQEILGAFMNTcMLHYATYRNTFPLWALAEYRKA 755
SQCY_1 cd02892
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ...
99-752 0e+00

Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.


Pssm-ID: 239222 [Multi-domain]  Cd Length: 634  Bit Score: 797.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  99 LRRGVLYYAACQANDGHWPSEVSGSMFLDAPFVICLYITGHlekIFTLEHVKELLRYMYNTQNEDGGWGLDVESHSVMFC 178
Cdd:cd02892    1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGI---PIDPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 179 TVLNYICLRILGVEPDHDgqksACARARKWILDHGGATYAPMVAKAWLSVLGVYDWSGCKPLPPEIWMLPSFSPINGGTL 258
Cdd:cd02892   78 TVLNYVALRLLGVSPDDP----HMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKF 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 259 WIYIRDLLMGMSYLYGKKFVATPTALILQLREELYPQPYSKIIWSKARNrcakeDLLYPKSFGQDLFWEGVHMLSEniiN 338
Cdd:cd02892  154 WCWARTVYVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRN-----DLYDYRPPWQRLFDALDRLLHW---Y 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 339 RWPLNKFVRQRALRTTMELVHYHDETTHYITGACVAKPFHMLACWVED-PDGDYFKKHLARVPDFIWIAEDGLKF-QLMG 416
Cdd:cd02892  226 EPLPPKPLRRKALRKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGyPDSPAFKRHLERIDDFLWLGPEGMKMcQTNG 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 417 MQSWNAALSLQVMLAANMDDEIRSTLIKGYDFLKQSQIsENPQGDHLKMFRDITKGGWTFQDREQGLPISDGTAESIECC 496
Cdd:cd02892  306 SQVWDTALAVQALLEAGLAPEFDPALKKALDWLLESQI-LDNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKAL 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 497 IHFHRMPSEfiGEKMDVEKLYDAVNFLIYLQSDNGGMPVWEPAPGKKWLEWLSPVEHVENTVVEQEYLECTGSVIAGLVC 576
Cdd:cd02892  385 LRLQELPPF--GEKVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGL 462
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 577 FKKEFPDHRpKEIEKLIKKGLKYIEDLQMPDGSWYGNWGVCFTYGTLFAVRGLAAAGKTFGNSEAIRRAVQFILNTQNAE 656
Cdd:cd02892  463 FGKLYPGHR-REIDPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYENSPYIRKACDFLLSKQNPD 541
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 657 GGWGESALSCPNKKYIPSKGnvTNVVNTGQAMMVLLIGGQMERDpsPVHRAAKVLINSQLDIGDFPQQERRGIYM-NMLL 735
Cdd:cd02892  542 GGWGESYLSYEDKSYAGGGR--STVVQTAWALLALMAAGEPDSE--AVERGIKYLLNTQLPDGDWPQEEITGVGFpNFYI 617
                        650
                 ....*....|....*..
gi 332007451 736 HYPTYRNMFSLWALALY 752
Cdd:cd02892  618 RYHNYRNYFPLWALGRY 634
squalene_cyclas TIGR01787
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ...
98-754 0e+00

squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.


Pssm-ID: 273809 [Multi-domain]  Cd Length: 621  Bit Score: 592.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451   98 ALRRGVLYYAACQANDGHWPSEVSGSMFLDAPFVICLYITGhlekIFTLEHVKELLRYMYNTQNEDGGWGLDVESHSVMF 177
Cdd:TIGR01787   1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIAD----TPLPGYREKIVRYLRHHQNEDGGWGLHIGGKSTVF 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  178 CTVLNYICLRILGVEPDHDgqksACARARKWILDHGGATYAPMVAKAWLSVLGVYDWSGCKPLPPEIWMLPSFSPINGGT 257
Cdd:TIGR01787  77 GTVLAYVALKILGMSPDDP----AMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSK 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  258 LWIYIRDLLMGMSYLYGKKFVATptaliLQLREELYPQPYSKiiwSKARNRCAKEDLLYPKSFGQDLFWegvhmLSENII 337
Cdd:TIGR01787 153 SWCRCRMVYLPMSYCYGERLSAP-----IDPREELYVEDDSI---RAQRNNVAKEDLYTPHSWLLRALY-----GLLNLF 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  338 NRWPLNKFVRQRALRTTMELVHYHDetthyiTGACVAKPFHMLACWVED-PDGDYFKKHLARVPDFIWIAEDGLKFQLMG 416
Cdd:TIGR01787 220 YHPFLRKALRKRALQWLYEHIAADG------SIGPISKAMAMLALWFLDgPNSPAFQKHLQRIDDYLWLQLDGMKMQGTG 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  417 MQSWNAALSLQVMLAANMD--DEIRSTLIKGYDFLKQSQISENPQGDHlKMFRDITK-GGWTFQDREQGLPI-SDGTAES 492
Cdd:TIGR01787 294 SQVWDTAFAIQALRESGDHrlPEFHPALVKAHEWLLLSQIPDNPPGDW-KVYRHNLKpGGWAFSFLNCGYPDvDDTAVVA 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  493 IECCIHFHRMpsefigEKMDVEKLYDAVNFLIYLQSDNGGMPVWEPAPGKKWLEWLSPVEHVENTVVEQEYLECTGSVIA 572
Cdd:TIGR01787 373 LKAVLLLQED------EHVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQ 446
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  573 GLVCFKkefpdHRPKEIEKLIKKGLKYIEDLQMPDGSWYGNWGVCFTYGTLFAVRGLAAAGKTFGNSEAIRRAVQFILNT 652
Cdd:TIGR01787 447 ALGAFG-----HRADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRNCPEVQKACDWLLSR 521
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  653 QNAEGGWGESALSCPNKKYIPSKGnvTNVVNTGQAMMVLLIGGQMERDpsPVHRAAKVLINSQLDIGDFPQQERRGIYM- 731
Cdd:TIGR01787 522 QMPDGGWGEDCFSYEDPSYVGSGG--STPSQTGWALMALIAAGEADSE--AIERGVKYLLETQRPDGDWPQEYITGVGFp 597
                         650       660
                  ....*....|....*....|....
gi 332007451  732 -NMLLHYPTYRNMFSLWALALYTN 754
Cdd:TIGR01787 598 kNFYLKYTNYRNIFPLWALGRYRQ 621
osq_cycl TIGR03463
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella ...
107-752 8.44e-130

2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella aurantiaca which produces cycloartenol, and Gemmata obscuriglobus and Methylococcus capsulatus, which each produce the closely related sterol, lanosterol.


Pssm-ID: 274591 [Multi-domain]  Cd Length: 634  Bit Score: 399.75  E-value: 8.44e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  107 AACQANDGHWPSEVSGSMFLDAPFVICLYITGhleKIFTLEHVKELLRYMYNTQNEDGGWGLDVESHSVMFCTVLNYICL 186
Cdd:TIGR03463   2 AALQDSAGDWEGDMGGCQFIIAIAVAGLHVMG---RPPDAEERAAIIAHFELHQLADGAWGLDPEAPGQVFFSVLAYVAL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  187 RILGVEPDhdgqKSACARARKWILDH-GGATYAPMVAKAWLSVLGVYDWSGCKPLPPEIWMLPSFSPINGGTLWIYIRDL 265
Cdd:TIGR03463  79 RLLGLGKD----DAGLARARAWFHAQpEGPKASGAWGKFILALLGLYEREGLNAVPPELFLLPESLPFHPSRFWCHCRLI 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  266 LMGMSYLYGKKFVATPTA-LILQLREELYPQPYSKIIWSKARNRCAKEDLLYPKSFgqdlfwegVHMLSENIINRWP--L 342
Cdd:TIGR03463 155 YLGIAWLSGRGARAPESDpLLAAIRQEIFAEGYEQVDFGAARERVAPTDLFTPISF--------VLKAANDLLAGYErlA 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  343 NKFVRQRALRTTMELVHYHDETTHYITGACVAKPFHMLACWVEDPDGDYFKKHLARVPDFIWIAED-GLKFqlMGMQS-- 419
Cdd:TIGR03463 227 GKALRARALDFAFEQILAEDEATHYICIGPINGLLNCLAIFAHDPDGPDLAAHLEGLEAWFWEDDAeGLRM--NGANSna 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  420 -WNAALSLQVMLA-ANMDDEIRSTLIKGYDFLKQSQISENPQgDHLKMFRDITKGGWTFQDREQGLPISDGTAESIECCI 497
Cdd:TIGR03463 305 lWDTAFAVQALAAlGELDEEAKHALEEAAAFIDAAQMLADLA-DPQEAFRDPAKGGWCFSDGDHCWPISDCAAEALKALF 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  498 HFHRMPSEFIGEKMDVEKLYDAVNFLIYLQSDNGGMPVWEPAPGKKWLEWLSPVEHVENTVVEQEYLECTGSVIAGLVCF 577
Cdd:TIGR03463 384 ALEELGDNRISEALGAARLQDAVEFILSMQNADGGFATYELQRGGKLLELLNPSDMFGQCMTDLSYVECTAACLGALAAW 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  578 KKEFPDHRPKEIEKLIKKGLKYIEDLQMPDGSWYGNWGVCFTYGTLFAVRGLAAAGKTfGNSEAIRRAVQFILNTQNAEG 657
Cdd:TIGR03463 464 LKHHPDLPDAKIDAAIRKAEEFIRRRQLDDGSFMGFWGICFTYATFFGAKGLIAAGAE-PADMALQAAAAFLLEKQRADG 542
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  658 GWGESALSCPNKKYIPSKGNVTnvVNTGQAMMVLLIGGQMERDpsPVHRAAKVLINSQLDIGDFPQQERRGIYMNM-LLH 736
Cdd:TIGR03463 543 AWGEHVESCLEARWVEGKHGHA--VMTAWALLALAAAGEAAHD--AAERGIAWLCEQQGEDGGWPPEGIAGIFFGAaAID 618
                         650
                  ....*....|....*.
gi 332007451  737 YPTYRNMFSLWALALY 752
Cdd:TIGR03463 619 YDAYLRIFPTWALARC 634
SqhC COG1657
Terpene cyclase SqhC [Lipid transport and metabolism];
76-757 9.53e-128

Terpene cyclase SqhC [Lipid transport and metabolism];


Pssm-ID: 441263 [Multi-domain]  Cd Length: 644  Bit Score: 394.96  E-value: 9.53e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  76 EQKIPRVRIEDAEKITYEDAKTALRRGVLYYAAcQANDGHWPSEVSGSMFLDAPFVICLYitgHLEKIFTLEHVKELLRY 155
Cdd:COG1657    2 IAPASASASSASNAEDRSLLDAAIAAAQALLLQ-QQDDGGWWGGELEADVTIAAEYILLH---HFLGPDDEELEAKIARY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 156 MYNTQNEDGGWGLDVESHSVMFCTVLNYICLRILGVEPDHdgqkSACARARKWILDHGGATYAPMVAKAWLSVLGVYDWS 235
Cdd:COG1657   78 LRRQQNDDGGWPLYHGGPGDLSTTVKAYFALKLLGDDPDA----PHMVRAREFILARGGAARANVFTKIWLALFGQYPWR 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 236 GCKPLPPEIWMLPSFSPINGGTLWIYIRDLLMGMSYLYGKKFVATPTALIlqLREELYPQPYSKIiwskarnrcakedLL 315
Cdd:COG1657  154 GVPALPPEIMLLPRWFPFHIYKFSYWARTVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQV-------------DY 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 316 YPKSFGQDLFWEGVHMLSENIINRW-PLN-KFVRQRALRTTMELVHYHDE-TTHYIT-GACVAKPFHMLACWVEDPDGDY 391
Cdd:COG1657  219 YFPAPRDRSPWSRFFLALDRLLRAYeRLPpKPLRRRALRKAEDWILERLEgDGGLGGiFPAMVNSLMALLALGYPPDHPV 298
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 392 FKKHLARVPDFIWIAEDGLKFQLMGMQSWNAALSLQVMLAANMdDEIRSTLIKGYDFLKQSQISEnpQGDHLKMFRDITK 471
Cdd:COG1657  299 VRRALEALEKLLVETEDGARCQPCVSPVWDTALAVQALQEAGL-PEDHPALERAADWLLSKQILV--KGDWAVKRPDVEP 375
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 472 GGWTFQDREQGLPISDGTAESIECCIHFHRMPSEFIGEKMDveklyDAVNFLIYLQSDNGGMPVWEPAPGKKWLEWLSPV 551
Cdd:COG1657  376 GGWAFQFANDHYPDVDDTAVVLMALLRLRLPDEPRYREAIE-----RAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFA 450
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 552 EHveNTVVEQEYLECTGSVIAGLVCFkkefpdhRPKEIEKLIKKGLKYIEDLQMPDGSWYGNWGVCFTYGTLFAVRGLAA 631
Cdd:COG1657  451 DH--GALLDPPTADVTARCLEMLGQL-------GLTEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNA 521
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 632 AGKTfGNSEAIRRAVQFILNTQNAEGGWGESALSCPNKKYIPSKgnVTNVVNTGQAMMVLLIGGqmERDPSPVHRAAKVL 711
Cdd:COG1657  522 AGVD-PDDPAIRRAVAWLLSIQNADGGWGEDCRSYEDPRYVGLG--PSTASQTAWALLALLAAG--EADSPAVARGIAYL 596
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*...
gi 332007451 712 INSQLDIGDFPQQERRGIYMN--MLLHYPTYRNMFSLWALALYTNALR 757
Cdd:COG1657  597 LSTQREDGSWDEEYFTGTGFPrvFYLRYHLYRQYFPLWALARYRNLRG 644
SQCY cd02889
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ...
418-752 1.80e-126

Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.


Pssm-ID: 239219 [Multi-domain]  Cd Length: 348  Bit Score: 381.18  E-value: 1.80e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 418 QSWNAALSLQVMLAANMDDEIRSTLIKGYDFLKQSQISENPqGDHLKMFRDITKGGWTFQDREQGLPISDGTAESIECCI 497
Cdd:cd02889   24 QVWDTALALQALLEAGLAPEFDPALKKALEWLLKSQIRDNP-DDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALL 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 498 HFHRMPSEfiGEKMDVEKLYDAVNFLIYLQSDNGGMPVWEPAPGKKWLEWlsPVEHVENTVVEQEYLECTGSVIAGLVCF 577
Cdd:cd02889  103 RLQKKPPD--GKKVSRERLYDAVDWLLSMQNSNGGFAAFEPDNTYKYLEL--IPEVDGDIMIDPPYVECTGSVLEALGLF 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 578 KKEFPDHRpKEIEKLIKKGLKYIEDLQMPDGSWYGNWGVCFTYGTLFAVRGLAAAGKTfGNSEAIRRAVQFILNTQNAEG 657
Cdd:cd02889  179 GKLYPEHR-REIDPAIRRAVKYLEREQEPDGSWYGRWGVCFIYGTWFALEALAAAGED-ENSPYVRKACDWLLSKQNPDG 256
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 658 GWGESALSCPNKKYIPSKGnvTNVVNTGQAMMVLLIGGQMERDpsPVHRAAKVLINSQLDIGDFPQQERRGIYM-NMLLH 736
Cdd:cd02889  257 GWGESYESYEDPSYAGGGR--STVVQTAWALLALMAAGEPDSE--AVKRGVKYLLNTQQEDGDWPQEEITGVFFkNFYIR 332
                        330
                 ....*....|....*.
gi 332007451 737 YPTYRNMFSLWALALY 752
Cdd:cd02889  333 YHNYRNYFPLWALGRY 348
hopene_cyclase TIGR01507
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) ...
92-755 5.15e-47

squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products. [Fatty acid and phospholipid metabolism, Other]


Pssm-ID: 273661 [Multi-domain]  Cd Length: 635  Bit Score: 177.39  E-value: 5.15e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451   92 YEDAKTALRRGVLYYAACQANDGHWPSEVSGSMFLDAPFVICLYITGHLEKIfTLEHVKellRYMYNTQNEDGGWGLDVE 171
Cdd:TIGR01507  11 TARTVEAIDRAVDYLLSCQKDEGYWWGELESNVTIEAEYVLLCHILDRVDRD-RMEKIR---NYLLHEQREDGTWALYPG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  172 SHSVMFCTVLNYICLRILGVEPDHDGQKsacaRARKWILDHGGATYAPMVAKAWLSVLGVYDWSGCKPLPPEIWMLPSFS 251
Cdd:TIGR01507  87 GPGDLSTTVEAYVALKYIGMSRDEPPMQ----KALRFIQSQGGIESSRVFTRMWLALVGEYPWRGVPMVPPEIMLLPKRF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  252 PINGGTLWIYIRDLLMGMSYLYGKKFVAtPTALILQLREELYPQPyskiiwSKARNRCAKEDLLYPKSFGQDLFWEGVHM 331
Cdd:TIGR01507 163 PFNIYEFSSWARATVVPLSIVCSRKPVF-PLPERARVPELYETDV------PKPRRRGAKGGTGWGIFDALDRALHGYEK 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  332 LSENiinrwPLNKFVRQRALRTTMELVHYHDETthyitGACVAKPFH-MLACWV--EDPDGDYFKKHLARVPDFIWIAED 408
Cdd:TIGR01507 236 LSVH-----PFRRAAEIRALDWLLERQAGDGSW-----GGIQPAMFNaLIALKIlgMTQHDAFIKLGWEGIDLYGVELDD 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  409 GLKFQLMGMQSWNAALSLQVMLAANM-DDEIRstLIKGYDFLKQSQISEnpQGDHLKMFRDITKGGWTFQDREQGLPISD 487
Cdd:TIGR01507 306 SWMFQACVSPVWDTALAVLALREAGLpADHDA--LVKAGEWLLDKQITV--PGDWAVKRPNLEPGGWAFQFDNVYYPDVD 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  488 GTAeSIECCIHFHRMPSEfigEKMDvEKLYDAVNFLIYLQSDNGGMPVWEPAPGKKWLEWLSPVEHVEntVVEQEYLECT 567
Cdd:TIGR01507 382 DTA-VVVWALNGLRLPDE---RRRR-DAMTKAFRWIAGMQSSNGGWGAFDVDNTSDLLNHIPFCDFGA--VTDPPTADVT 454
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  568 GSVIAGLVCFKKEFPdhrpkeiEKLIKKGLKYIEDLQMPDGSWYGNWGVCFTYGTLFAVRGLAAAG-KTFGNSeaIRRAV 646
Cdd:TIGR01507 455 ARVLECLGSFGYDDA-------WPVIERAVEYLKREQEPDGSWFGRWGVNYLYGTGAVLSALKAVGiDTREPY--IQKAL 525
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  647 QFILNTQNAEGGWGESALSCPNKKYiPSKGNVTnVVNTGQAMMVLLIGGqmERDPSPVHRAAKVLINSQLDIG--DFPQQ 724
Cdd:TIGR01507 526 AWLESHQNPDGGWGEDCRSYEDPAY-AGKGAST-ASQTAWALIALIAAG--RAESEAARRGVQYLVETQRPDGgwDEPYY 601
                         650       660       670
                  ....*....|....*....|....*....|.
gi 332007451  725 ERRGIYMNMLLHYPTYRNMFSLWALALYTNA 755
Cdd:TIGR01507 602 TGTGFPGDFYLGYHMYRHVFPLLALARYKQA 632
ISOPREN_C2_like cd00688
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ...
418-752 2.69e-36

This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.


Pssm-ID: 238362 [Multi-domain]  Cd Length: 300  Bit Score: 138.84  E-value: 2.69e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 418 QSWNAALSLQVML----AANMDDEIRSTLIKGYDFLKQSQISenpqgdhlkmfrditKGGWTFQDReQGLPISDGTAESI 493
Cdd:cd00688   26 QTWSTAWPLLALLlllaATGIRDKADENIEKGIQRLLSYQLS---------------DGGFSGWGG-NDYPSLWLTAYAL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 494 ECCIHFHRMpsefigEKMDVEKLYDAVNFLIYLQSDNGGmpvwepapgkkwleWLSPVEHVENTVVEQEYLECTGSVIAG 573
Cdd:cd00688   90 KALLLAGDY------IAVDRIDLARALNWLLSLQNEDGG--------------FREDGPGNHRIGGDESDVRLTAYALIA 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 574 LVCFKKEFPDhrpkeieKLIKKGLKYIEDLQMPDGSWyGNWGVCFTYGTLFAVRGLAAAGKTfgNSEAIRRAVQFILNTQ 653
Cdd:cd00688  150 LALLGKLDPD-------PLIEKALDYLLSCQNYDGGF-GPGGESHGYGTACAAAALALLGDL--DSPDAKKALRWLLSRQ 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 654 NAEGGWGESALScPNKKYipskgnvtNVVNTGQAMMVLLIGGQMeRDPSPVHRAAKVLINSQLDIGDFPQQERrgiymnm 733
Cdd:cd00688  220 RPDGGWGEGRDR-TNKLS--------DSCYTEWAAYALLALGKL-GDLEDAEKLVKWLLSQQNEDGGFSSKPG------- 282
                        330
                 ....*....|....*....
gi 332007451 734 lLHYPTYRNMFSLWALALY 752
Cdd:cd00688  283 -KSYDTQHTVFALLALSLY 300
SQHop_cyclase_N pfam13249
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ...
110-352 5.03e-31

Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.


Pssm-ID: 433061 [Multi-domain]  Cd Length: 290  Bit Score: 123.36  E-value: 5.03e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  110 QANDGHWPSEVSGSMFLDAPFVICLYITGHLEKifTLEHvkELLRYMYNTQNEDGGWGLDVESHSVMFCTVLNYICLRIL 189
Cdd:pfam13249  12 QHPDGHWVGELEANVTITAEYILLRHFLGPDDP--ELEA--KIARYLRSQQREDGGWPLFHGGPGDLSTTVEAYFALKLL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  190 GVEPDHdgqkSACARARKWILDHGGATYAPMVAKAWLSVLGVYDWSGCKPLPPEIWMLPSFSPINggtlwIY-----IRD 264
Cdd:pfam13249  88 GDSPDA----PHMVRAREFILARGGAAKANVFTRIWLALFGQYPWRGVPSMPPEIMLLPRWFPFN-----IYkfsswART 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  265 LLMGMSYLYGKKFVA-TPTALILQlreELYPQPYSKIiwskaRNRCAKEDLLYPKsfgqDLFWEGVHMLSenIINRWPLn 343
Cdd:pfam13249 159 TIVPLLILSALKPVApLPPGIGLD---ELFVEPPENV-----RYYPRPHRLFSWT----NLFLGLDRVLK--LYERLPP- 223

                  ....*....
gi 332007451  344 KFVRQRALR 352
Cdd:pfam13249 224 KPLRRRALR 232
SQHop_cyclase_C pfam13243
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ...
420-754 1.25e-29

Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.


Pssm-ID: 433057 [Multi-domain]  Cd Length: 319  Bit Score: 120.13  E-value: 1.25e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  420 WNAALSLQVMLAANMDDEIRStLIKGYDFLKQSQISEnpQGDHLKMFRDITKGGWTFQDREQGLPISDGTAESIECCIHF 499
Cdd:pfam13243   5 WDTALALHALLEAGVPADHPA-LVKAAQWLLDRQVLV--KGDWAVKRPDLEPGGWAFQFANDHYPDVDDTAVVVLALDRV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  500 HRmPSEfigEKMDvEKLYDAVNFLIYLQSDNGGMPVWEPAPGKKWLEWLSPVEHveNTVVEQEYLECTGSVIAGLVCFkk 579
Cdd:pfam13243  82 RL-PDE---RRRD-DAIARGIEWILGMQSKNGGWGAFDKDNTKYYLNKIPFADH--GALLDPPTADVTARVLEMLGQL-- 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  580 EFPDHRPkeiekLIKKGLKYIEDLQMPDGSWYGNWGVCFTYGTLFAVRGLAAAGKTFgNSEAIRRAVQFILNTQNAEGGW 659
Cdd:pfam13243 153 GYPDDHP-----VAARALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDH-NRPYIRKAVDWLKSRQNPDGGW 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  660 GESALSCPNKKYIpSKGNVTnVVNTGQAMMVLLIGGQMERDpsPVHRAAKVLINSQLDIGDFpqQERR----GIYMNMLL 735
Cdd:pfam13243 227 GEDCESYKDPKLA-GRGPST-ASQTAWALLALMAAGEVDSP--AVRRGIQYLLETQKPDGTW--DEPYftgtGFPRVFYL 300
                         330
                  ....*....|....*....
gi 332007451  736 HYPTYRNMFSLWALALYTN 754
Cdd:pfam13243 301 KYHGYRNYFPLWALARYRN 319
squa_tetra_cyc TIGR04277
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, ...
89-752 4.74e-20

squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, occurs a small number of eukaryotes, some of them anaerobic. The pathway can occur under anaerobic conditions, and the product is thought to replace sterols, letting organisms with this compound build membrane suitable for performing phagocytosis.


Pssm-ID: 212000 [Multi-domain]  Cd Length: 624  Bit Score: 95.08  E-value: 4.74e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451   89 KITYEDAKTALR--RGVLYyAACQANDGHWPSEVsGSMFLDAPFVICLYITGHLEKIFTLEHVKELLrymYNTQNEDGGW 166
Cdd:TIGR04277  13 KVDIEEVQNAIRdaQEICW-AELHDNEWVYPPYL-GELFISEYYFELKALGWIHKSAFEASKFTEIL---LGSQFEDGSW 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  167 gLDVESHSV----MFCTVLNYICLRILGVEPDHDgqkSACARARKWILDHGGATYAPMVAKAWLSVLGVYDWSgckplpp 242
Cdd:TIGR04277  88 -EQVEDANIetgqLDATIFNYWYLKAIGIDIHID---AALKKAQEWIKANGGIEAAQTMTKFKLAAFGQYPWE------- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  243 EIWMLPSF-SPINGGTLWIYIRDL--------LMGMSYLYGKKFV-ATPTALIlqlrEELYPQPYSKIIWSKARNRCAke 312
Cdd:TIGR04277 157 DLFKIPLFiFKKKGIFKPLYIKDItaqwvyphLTALAYLQNQRIIfNVAVADI----RELWINKAKKGIKHQKKERPS-- 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  313 dlLYPKSFGQDLFWEGVHMlseniinRWPLNKF--VRQRALRTTMELVHYHDETTHYITGAcVAKPFHMLACWVEDPDGD 390
Cdd:TIGR04277 231 --FFIDNDLLILMDEIFKL-------KQPLGSFgaYTISTLLSLLAFKDFQGKHPHKHKNE-IQDALEDGLDFVEFNYFN 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  391 YFKKHLARVPDFIWiaedglkfqlmgmqsWNAALSLQVMLAANMDDE-IRSTLikgydflkQSQISENPQgdhlkmfrdi 469
Cdd:TIGR04277 301 FREAYHGSLDDGRW---------------WDTILISWAMLESGEDKEkIFPIV--------ENMLKEGLQ---------- 347
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  470 TKGGWTFQDREQGLPISDGTAESIECCIHFhrmpSEFIGEKMDveklyDAVNFLIYLQSDNGGMPVWEPAPGKKWL--EW 547
Cdd:TIGR04277 348 PKGGIEYGYDFEYAPDADDTGLLLQVLSYY----GEAFADAID-----EGAEFLFSMQNDDGGFPAFDKGKMEDNLlfKF 418
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  548 LSPVEHVENT--VVEQEYLECTGSVIAGLVcfkkEFPDHRPKEIeklIKKGLKYIEDLQMPDGSWYGNWGVCFTYGTLFA 625
Cdd:TIGR04277 419 AFKIAGIADSaeIFDPSCPDITAHILEGLG----EFGDQANHDQ---IQKMIKYFMDTQEKFGSWEARWGINYIMAAGAV 491
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  626 VRGLAAAGKTFGNSEAiRRAVQFILNTQNAEGGWGESALSCPNkkyiPSKGN---VTNVVNTGQAMMVLL-IGGQMERDP 701
Cdd:TIGR04277 492 LPALAKMNYDLNEGWA-KNAINWLLNKQNADGGFGECTLSYND----PEKWNgigKSTVTQTSWGLLALLaVEDHNDQIK 566
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 332007451  702 SPVHRAAKVLINS-QLDIGDFPQQE-----RRGIymnMLLHYPTYRNMFSLWALALY 752
Cdd:TIGR04277 567 EAADKAAQYLLDQfKRDDGEFKDHStigtgHRGL---LYLQYPSYAQSFPLIALGRF 620
ISOPREN_C2_like cd00688
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ...
593-751 3.43e-08

This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.


Pssm-ID: 238362 [Multi-domain]  Cd Length: 300  Bit Score: 55.63  E-value: 3.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 593 IKKGLKYIEDLQMPDGSWYG------NWGVCFTygTLFAVRGLAAAGKTFGNSEAIRRAVQFILNTQNAEGGWGESalsc 666
Cdd:cd00688    1 IEKHLKYLLRYPYGDGHWYQslcgeqTWSTAWP--LLALLLLLAATGIRDKADENIEKGIQRLLSYQLSDGGFSGW---- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 667 pnkkyipSKGNVTNVVNTGQAMMVLLIGGQME-RDPSPVHRAAKVLINSQLDIGDFpqQERRGIYMNMLLHYPTYRNM-F 744
Cdd:cd00688   75 -------GGNDYPSLWLTAYALKALLLAGDYIaVDRIDLARALNWLLSLQNEDGGF--REDGPGNHRIGGDESDVRLTaY 145

                 ....*..
gi 332007451 745 SLWALAL 751
Cdd:cd00688  146 ALIALAL 152
Prenyltrans pfam00432
Prenyltransferase and squalene oxidase repeat;
593-633 2.29e-07

Prenyltransferase and squalene oxidase repeat;


Pssm-ID: 395346 [Multi-domain]  Cd Length: 44  Bit Score: 47.51  E-value: 2.29e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 332007451  593 IKKGLKYIEDLQMPDGSWYGNWGVC-FTYGTLFAVRGLAAAG 633
Cdd:pfam00432   3 KEKLVDYLLSCQNEDGGFGGRPGGEsDTYYTYCALAALALLG 44
Prenyltrans pfam00432
Prenyltransferase and squalene oxidase repeat;
147-190 1.83e-05

Prenyltransferase and squalene oxidase repeat;


Pssm-ID: 395346 [Multi-domain]  Cd Length: 44  Bit Score: 42.50  E-value: 1.83e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 332007451  147 EHVKELLRYMYNTQNEDGGWGLDVESHSVMFCTVLNYICLRILG 190
Cdd:pfam00432   1 IDKEKLVDYLLSCQNEDGGFGGRPGGESDTYYTYCALAALALLG 44
ISOPREN_C2_like cd00688
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ...
98-212 4.40e-05

This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.


Pssm-ID: 238362 [Multi-domain]  Cd Length: 300  Bit Score: 46.00  E-value: 4.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  98 ALRRGVLYYAACQANDGHWPSEVSGSMFL-----DAPFVIC-LYITGHLEKIFTLEHVKELLRYMYNTQNEDGGWGLDVE 171
Cdd:cd00688  105 DLARALNWLLSLQNEDGGFREDGPGNHRIggdesDVRLTAYaLIALALLGKLDPDPLIEKALDYLLSCQNYDGGFGPGGE 184
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 332007451 172 SHS-VMFCTVlnyICLRILGvepdhDGQKSACARARKWILDH 212
Cdd:cd00688  185 SHGyGTACAA---AALALLG-----DLDSPDAKKALRWLLSR 218
CAL1 COG5029
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ...
597-749 2.54e-04

Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];


Pssm-ID: 444045 [Multi-domain]  Cd Length: 259  Bit Score: 43.54  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 597 LKYIEDLQMPDGSWYGNWGVCFTYGTLFAVRGLAAAGKTFGNSEAIrraVQFILNTQNAEGGWGesalSCPNKKYIpskg 676
Cdd:COG5029   25 LDYLRASQNPDGGFAGRSGPSDLYSTYYAVRTLALLGESPKWRDRV---ADLLSSLRVEDGGFA----KAPEGGAG---- 93
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 332007451 677 nvtnvvNTGQAMMVLLIGGQMERDPSPVHRAAKVLINSQLDIGDFPQQERRGIYMNmllhyPTYRNMFSLWAL 749
Cdd:COG5029   94 ------STYHTYLATLLAELLGRPPPDPDRLVRFLISQQNDDGGFEISPGRRSDTN-----PTAAAIGALRAL 155
GGTase-II cd02894
Geranylgeranyltransferase type II (GGTase-II)_like proteins containing the protein ...
583-660 8.89e-04

Geranylgeranyltransferase type II (GGTase-II)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-IIs are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes. PTases catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Prenyltransferases employ a Zn2+ ion to alkylate a thiol group catalyzing the formation of thioether linkages between cysteine residues at or near the C-terminus of protein acceptors and the C1 atom of isoprenoid lipids (geranylgeranyl (20-carbon) in the case of GGTase-II ). GGTase-II catalyzes alkylation of both cysteine residues in Rab proteins containing carboxy-terminal "CC", "CXCX" or "CXC" motifs. PTases are heterodimeric with both alpha and beta subunits required for catalytic activity. In contrast to other prenyltransferases, GGTas-II requires an escort protein to bring the substrate protein to the catalytic heterodimer and to escort the geryanylgeranylated product to the membrane.


Pssm-ID: 239224 [Multi-domain]  Cd Length: 287  Bit Score: 41.87  E-value: 8.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 583 DHRPKEIEKLIKkglkYIEDLQMPDGSWYGN-WG---VCFTYGtlfAVRGLAAAGKTfgNSEAIRRAVQFILNTQNAEGG 658
Cdd:cd02894   96 NKIDENKEKIAK----FIKGLQNEDGSFSGDkWGevdTRFSYC---AVLCLTLLGKL--DLIDVDKAVDYLLSCYNFDGG 166

                 ..
gi 332007451 659 WG 660
Cdd:cd02894  167 FG 168
ISOPREN_C2_like cd00688
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ...
91-212 1.19e-03

This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.


Pssm-ID: 238362 [Multi-domain]  Cd Length: 300  Bit Score: 41.77  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  91 TYEDAKTALRRGVLYYAACQANDG---HWPSEVSGSMFLDAPFVICLYITGHLEKIFTlEHVKELLRYMYNTQNEDGGWG 167
Cdd:cd00688   46 IRDKADENIEKGIQRLLSYQLSDGgfsGWGGNDYPSLWLTAYALKALLLAGDYIAVDR-IDLARALNWLLSLQNEDGGFR 124
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 332007451 168 -LDVESHSVMFCTV---LNYICLRILGvEPDHDGQKSACARARKWILDH 212
Cdd:cd00688  125 eDGPGNHRIGGDESdvrLTAYALIALA-LLGKLDPDPLIEKALDYLLSC 172
SQCY cd02889
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ...
99-226 1.94e-03

Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.


Pssm-ID: 239219 [Multi-domain]  Cd Length: 348  Bit Score: 41.05  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  99 LRRGVLYYAACQANDGHWPSEVSGSMflDAPFVIcLYI--TGHLEKifTLEHVKELLRYMYNTQNED------------- 163
Cdd:cd02889    1 IRRALDFLLSLQAPDGHWPGEYSQVW--DTALAL-QALleAGLAPE--FDPALKKALEWLLKSQIRDnpddwkvkyrhlr 75
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 332007451 164 -GGWGLDVESHS--VMFCTVLNYICLRILGvEPDHDGQK---SACARARKWIL----DHGG-ATYAPMVAKAWL 226
Cdd:cd02889   76 kGGWAFSTANQGypDSDDTAEALKALLRLQ-KKPPDGKKvsrERLYDAVDWLLsmqnSNGGfAAFEPDNTYKYL 148
ISOPREN_C2_like cd00688
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ...
99-212 2.25e-03

This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.


Pssm-ID: 238362 [Multi-domain]  Cd Length: 300  Bit Score: 40.61  E-value: 2.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451  99 LRRGVLYYAACQANDGHWPSEVSGS--MFLDAPFV-ICLYITGHLEKIFTLEHVKELLRYMYNTQNEDGGWGLDVESH-S 174
Cdd:cd00688    1 IEKHLKYLLRYPYGDGHWYQSLCGEqtWSTAWPLLaLLLLLAATGIRDKADENIEKGIQRLLSYQLSDGGFSGWGGNDyP 80
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 332007451 175 VMFCTVLNYICLRILGvePDHDGQKSACARARKWILDH 212
Cdd:cd00688   81 SLWLTAYALKALLLAG--DYIAVDRIDLARALNWLLSL 116
CAL1 COG5029
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ...
105-217 2.51e-03

Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];


Pssm-ID: 444045 [Multi-domain]  Cd Length: 259  Bit Score: 40.46  E-value: 2.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332007451 105 YYAACQANDGHW---PSEVSGSMFLDAPFVICLYITGHlekifTLEHVKELLRYMYNTQNEDGGWGLDVESHSVMFCTVL 181
Cdd:COG5029   73 LLSSLRVEDGGFakaPEGGAGSTYHTYLATLLAELLGR-----PPPDPDRLVRFLISQQNDDGGFEISPGRRSDTNPTAA 147
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 332007451 182 NYICLRILGV-EPDHDgqksacARARKWILDH----GGATY 217
Cdd:COG5029  148 AIGALRALGAlDDPIE------TKVIRFLRDVqspeGGFAY 182
SQHop_cyclase_N pfam13249
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ...
640-660 9.98e-03

Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.


Pssm-ID: 433061 [Multi-domain]  Cd Length: 290  Bit Score: 38.62  E-value: 9.98e-03
                          10        20
                  ....*....|....*....|.
gi 332007451  640 EAIRRAVQFILNTQNAEGGWG 660
Cdd:pfam13249 229 RALRKAEEWILERQEGDGGLG 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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