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Conserved domains on  [gi|332003212|gb|AED90595|]
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Heavy metal transport/detoxification superfamily protein [Arabidopsis thaliana]

Protein Classification

heavy-metal-associated domain-containing protein( domain architecture ID 10449815)

heavy-metal-associated domain-containing protein may function as a heavy metal transporter and/or detoxification protein; such as heavy metal-associated isoprenylated plant proteins

Gene Ontology:  GO:0046872
PubMed:  12443926|8905098

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
HMA pfam00403
Heavy-metal-associated domain;
4-56 9.71e-09

Heavy-metal-associated domain;


:

Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 51.08  E-value: 9.71e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 332003212    4 DMHCEGCGKKIKRIFKHFKGVEDVKIDYKSNKLTVIGNVDPVEVRdKVADKIK 56
Cdd:pfam00403   6 GMHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAESTKLE-KLVEAIE 57
HMA pfam00403
Heavy-metal-associated domain;
135-190 5.57e-07

Heavy-metal-associated domain;


:

Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 46.07  E-value: 5.57e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 332003212  135 LHCEGCEHKIKRIVNKIKGVNSVAIDSAKDLVIVKGiidvkQLTPYLNEKLKRTVE 190
Cdd:pfam00403   7 MHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTG-----DAESTKLEKLVEAIE 57
 
Name Accession Description Interval E-value
HMA pfam00403
Heavy-metal-associated domain;
4-56 9.71e-09

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 51.08  E-value: 9.71e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 332003212    4 DMHCEGCGKKIKRIFKHFKGVEDVKIDYKSNKLTVIGNVDPVEVRdKVADKIK 56
Cdd:pfam00403   6 GMHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAESTKLE-KLVEAIE 57
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 5-53 4.73e-08

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 49.14  E-value: 4.73e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 332003212   5 MHCEGCGKKIKRIFKHFKGVEDVKIDYKSNKLTVIGN--VDPVEVRDKVAD 53
Cdd:cd00371    7 MTCAGCVSKIEKALEKLPGVESVEVDLETGKATVEYDpeVSPEELLEAIED 57
HMA pfam00403
Heavy-metal-associated domain;
135-190 5.57e-07

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 46.07  E-value: 5.57e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 332003212  135 LHCEGCEHKIKRIVNKIKGVNSVAIDSAKDLVIVKGiidvkQLTPYLNEKLKRTVE 190
Cdd:pfam00403   7 MHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTG-----DAESTKLEKLVEAIE 57
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
4-53 8.94e-06

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 42.97  E-value: 8.94e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 332003212   4 DMHCEGCGKKIKRIFKHFKGVEDVKIDYKSNKLTVIGN---VDPVEVRDKVAD 53
Cdd:COG2608   10 GMTCGHCVARVEKALKALDGVASVEVDLATGTATVTYDpekVSLEDIKAAIEE 62
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 135-174 1.27e-05

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 42.59  E-value: 1.27e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 332003212 135 LHCEGCEHKIKRIVNKIKGVNSVAIDSAKDLVIVKGIIDV 174
Cdd:cd00371    7 MTCAGCVSKIEKALEKLPGVESVEVDLETGKATVEYDPEV 46
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
128-190 1.91e-04

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 39.50  E-value: 1.91e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 332003212 128 TVVLKTK-LHCEGCEHKIKRIVNKIKGVNSVAIDSAKDLVIVKGiiDVKQLTPylnEKLKRTVE 190
Cdd:COG2608    3 TVTLKVEgMTCGHCVARVEKALKALDGVASVEVDLATGTATVTY--DPEKVSL---EDIKAAIE 61
PLN02957 PLN02957
copper, zinc superoxide dismutase
 4-45 2.30e-03

copper, zinc superoxide dismutase


Pssm-ID: 215516 [Multi-domain]  Cd Length: 238  Bit Score: 38.96  E-value: 2.30e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 332003212   4 DMHCEGCGKKIKRIFKHFKGVEDVKIDYKSNKLTVIGNvDPV 45
Cdd:PLN02957  13 DMKCEGCVAAVKNKLETLEGVKAVEVDLSNQVVRVLGS-SPV 53
 
Name Accession Description Interval E-value
HMA pfam00403
Heavy-metal-associated domain;
4-56 9.71e-09

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 51.08  E-value: 9.71e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 332003212    4 DMHCEGCGKKIKRIFKHFKGVEDVKIDYKSNKLTVIGNVDPVEVRdKVADKIK 56
Cdd:pfam00403   6 GMHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAESTKLE-KLVEAIE 57
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 5-53 4.73e-08

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 49.14  E-value: 4.73e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 332003212   5 MHCEGCGKKIKRIFKHFKGVEDVKIDYKSNKLTVIGN--VDPVEVRDKVAD 53
Cdd:cd00371    7 MTCAGCVSKIEKALEKLPGVESVEVDLETGKATVEYDpeVSPEELLEAIED 57
HMA pfam00403
Heavy-metal-associated domain;
135-190 5.57e-07

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 46.07  E-value: 5.57e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 332003212  135 LHCEGCEHKIKRIVNKIKGVNSVAIDSAKDLVIVKGiidvkQLTPYLNEKLKRTVE 190
Cdd:pfam00403   7 MHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTG-----DAESTKLEKLVEAIE 57
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
4-53 8.94e-06

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 42.97  E-value: 8.94e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 332003212   4 DMHCEGCGKKIKRIFKHFKGVEDVKIDYKSNKLTVIGN---VDPVEVRDKVAD 53
Cdd:COG2608   10 GMTCGHCVARVEKALKALDGVASVEVDLATGTATVTYDpekVSLEDIKAAIEE 62
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 135-174 1.27e-05

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 42.59  E-value: 1.27e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 332003212 135 LHCEGCEHKIKRIVNKIKGVNSVAIDSAKDLVIVKGIIDV 174
Cdd:cd00371    7 MTCAGCVSKIEKALEKLPGVESVEVDLETGKATVEYDPEV 46
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
128-190 1.91e-04

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 39.50  E-value: 1.91e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 332003212 128 TVVLKTK-LHCEGCEHKIKRIVNKIKGVNSVAIDSAKDLVIVKGiiDVKQLTPylnEKLKRTVE 190
Cdd:COG2608    3 TVTLKVEgMTCGHCVARVEKALKALDGVASVEVDLATGTATVTY--DPEKVSL---EDIKAAIE 61
PLN02957 PLN02957
copper, zinc superoxide dismutase
 4-45 2.30e-03

copper, zinc superoxide dismutase


Pssm-ID: 215516 [Multi-domain]  Cd Length: 238  Bit Score: 38.96  E-value: 2.30e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 332003212   4 DMHCEGCGKKIKRIFKHFKGVEDVKIDYKSNKLTVIGNvDPV 45
Cdd:PLN02957  13 DMKCEGCVAAVKNKLETLEGVKAVEVDLSNQVVRVLGS-SPV 53
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
5-53 3.49e-03

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 39.36  E-value: 3.49e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 332003212   5 MHCEGCGKKIKRIFKHFKGVEDVKIDYKSNKLTVI---GNVDPVEVRDKVAD 53
Cdd:COG2217   10 MTCAACAWLIEKALRKLPGVLSARVNLATERARVEydpGKVSLEELIAAVEK 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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