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Conserved domains on  [gi|325065662|gb|ADY73669|]
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Mg2 transporter protein CorA family protein [Desulfurobacterium thermolithotrophum DSM 11699]

Protein Classification

magnesium transporter CorA family protein( domain architecture ID 10191267)

magnesium transporter CorA family protein belonging to the CorA metal ion transporter (MIT) superfamily, similar to CorA which mediates both influx and efflux of magnesium, and may also transport nickel and cobalt

CATH:  3.30.460.20|1.20.58.340
Gene Ontology:  GO:0046873|GO:0030001
PubMed:  17619822|23046658|16179994
SCOP:  4000404|3000358

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TmCorA-like cd12822
Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential ...
 38-319 2.85e-87

Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the Thermotoga maritima CorA_like family are found in all three kingdoms of life. It is a functionally diverse family, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


:

Pssm-ID: 213356 [Multi-domain]  Cd Length: 289  Bit Score: 263.28  E-value: 2.85e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  38 WIHLRGIDEQVENFLLKNFKINELSLEDCRSEG-RSKVEVFEDYVFVLMIYF----DGGISRQKKLCIFWGKDFIITIGS 112
Cdd:cd12822    1 WIDLEGPTEEELQLLAEEFGFHPLAIEDALNERqRPKIEEYDDYLFLVLRALrydeEELELETSELSIFLGKNFLVTVHE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 113 RRLF--EETRKNLSLEERPFEQGVERIFWLISSIVADKFKGVTDILEEQADEIEARVFKEQNPELLEDISDLSFEILTLR 190
Cdd:cd12822   81 GPLRliDEVIERLLSDPKLLPKGPDFLLYAILDAIVDSYFPILDELEDRLDELEDEILEEPRREVLRELFALRRELLRLR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 191 RTLKQLRDTYKSLISSVSRFINPENIHYFRDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIMKTLTILITILE 270
Cdd:cd12822  161 RILSPQREVLNRLLRRENELISEELRPYFRDVYDHLERLAELLDSYRDLLSSLLDAYLSLQSNRTNEVMKVLTIITTIFL 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 325065662 271 PLMLISSFYGMNIEELPFAHSPYGIFVISFLMIGISFFLLYYFRRKGWI 319
Cdd:cd12822  241 PLTFITGIYGMNFEYMPELHWPYGYFIVLGIMLLIAGGLLWWFRRKKWL 289
 
Name Accession Description Interval E-value
TmCorA-like cd12822
Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential ...
 38-319 2.85e-87

Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the Thermotoga maritima CorA_like family are found in all three kingdoms of life. It is a functionally diverse family, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213356 [Multi-domain]  Cd Length: 289  Bit Score: 263.28  E-value: 2.85e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  38 WIHLRGIDEQVENFLLKNFKINELSLEDCRSEG-RSKVEVFEDYVFVLMIYF----DGGISRQKKLCIFWGKDFIITIGS 112
Cdd:cd12822    1 WIDLEGPTEEELQLLAEEFGFHPLAIEDALNERqRPKIEEYDDYLFLVLRALrydeEELELETSELSIFLGKNFLVTVHE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 113 RRLF--EETRKNLSLEERPFEQGVERIFWLISSIVADKFKGVTDILEEQADEIEARVFKEQNPELLEDISDLSFEILTLR 190
Cdd:cd12822   81 GPLRliDEVIERLLSDPKLLPKGPDFLLYAILDAIVDSYFPILDELEDRLDELEDEILEEPRREVLRELFALRRELLRLR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 191 RTLKQLRDTYKSLISSVSRFINPENIHYFRDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIMKTLTILITILE 270
Cdd:cd12822  161 RILSPQREVLNRLLRRENELISEELRPYFRDVYDHLERLAELLDSYRDLLSSLLDAYLSLQSNRTNEVMKVLTIITTIFL 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 325065662 271 PLMLISSFYGMNIEELPFAHSPYGIFVISFLMIGISFFLLYYFRRKGWI 319
Cdd:cd12822  241 PLTFITGIYGMNFEYMPELHWPYGYFIVLGIMLLIAGGLLWWFRRKKWL 289
CorA COG0598
Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];
29-319 1.70e-74

Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];


Pssm-ID: 440363 [Multi-domain]  Cd Length: 305  Bit Score: 231.26  E-value: 1.70e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  29 EELLKKSPKWIHLRGIDEQVENFLLKNFKINELSLEDCRSEG-RSKVEVFEDYVFVLM----IYFDGGISRQKKLCIFWG 103
Cdd:COG0598    8 ELLDPEGFVWIDLDGPTDEELEWLAEEFGLHPLALEDALDIEqRPKLEEYDDYLFIVLrtlnYNEEEEELETGPLSIFLG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 104 KDFIITI--GSRRLFEETRKNLSLEERPFEQGVERIFWLISSIVADKFKGVTDILEEQADEIEARVFKEQNPELLEDISD 181
Cdd:COG0598   88 PNFLITVreRPLDAFDDVRERLERGPGLLPRGPDYLLYALLDAIVDRYFPVLEELEDELDELEDELFESPDNELLRRLYR 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 182 LSFEILTLRRTLKQLRDTYKSLISSVSRFINPENIHYFRDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIMKT 261
Cdd:COG0598  168 LRRELVRLRRALAPLREVLSRLLRGESPLISEEDREYLRDVYDHLERLLEMVDSLRERLSGLLDAYLSLISNRQNEIMKV 247

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 325065662 262 LTILITILEPLMLISSFYGMNIEELPFAHSPYGIFVISFLMIGISFFLLYYFRRKGWI 319
Cdd:COG0598  248 LTIIAAIFLPPTFIAGIYGMNFEGMPELDWPYGYPIVLGLMLLIAVLLYLYFKRKGWL 305
CorA pfam01544
CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx ...
 34-315 6.61e-52

CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli. CorA is virtually ubiquitous in the Bacteria and Archaea. There are also eukaryotic relatives of this protein. The family includes the MRS2 protein from yeast that is thought to be an RNA splicing protein. However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.


Pssm-ID: 460246 [Multi-domain]  Cd Length: 292  Bit Score: 172.88  E-value: 6.61e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662   34 KSPKWIHLRGIDEQVENFLLKNFKINELSLEDC-RSEGRSKVEVFEDYVFVLMIYF----DGGISRQKKLCIFWGKDFII 108
Cdd:pfam01544   2 QGFVWLDLDSPTEAELEWLARTLGLDPLALEDLlDPEERPRVEDYDDYFLLVLPGVnlddSEEADELVTVSILLGDNFLI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  109 TIGSRRL--FEETRKNLSLEERPFeQGVERIFWLISSIVADKFKGVTDILEEQADEIEARVFKEQNPELLEDISDLSFEI 186
Cdd:pfam01544  82 TVRHEPLpaLDEVRKRLTLLGGGP-LDPGDLLYRLLDEIVDRFLELLEKLEDELDELEDELEDETNNELLRELAALRRSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  187 LTLRRTLKQLRDTYKSLISSVSRF-INPENIHYFRDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIMKTLTIL 265
Cdd:pfam01544 161 VYLRRSLLPQRDVLNRLLRREDDPlLDDEQKEYLRDLLDRLERLLEDLDALRERLRSLQDEYSSLLSERTNRVMKVLTVV 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 325065662  266 ITILEPLMLISSFYGMNIEELPFAHSPYGIFVISF--LMIGISFFLLYYFRR 315
Cdd:pfam01544 241 TAIFLPLTLITGIYGMNFGGLPELEWSYGYPFVLIlgLMILLAILLLFYFRR 292
corA TIGR00383
magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp ...
 38-319 2.71e-38

magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp Genomics 1998;3(3):151-69 discusses this family and suggests that some members may have functions other than Mg2+ transport. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273048 [Multi-domain]  Cd Length: 318  Bit Score: 137.90  E-value: 2.71e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662   38 WIHL-RGIDEQVENFLLKNFKINELSLEDCR-SEGRSKVEVFEDYVFVLMIYF-----DGGISRQkkLCIFWGKDFIITI 110
Cdd:TIGR00383  29 WIDLiEPTDEERLAKLGQFFAIHPLALEDILnSPQRPKVEEDEDHLFIISFFLnededDTFETEQ--VSFILGKNLLFTI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  111 GSRRL--FEETRKNLSLEERPFEQGVERIFWLISSIVADKFKGVTDILEEQADEIEARVFKEQNPELLEDISDLSFEILT 188
Cdd:TIGR00383 107 HERELpaFDSIRERIRTSQKVFEKGADYLLYDIFDAIIDSYFPLLENIEDELEELEDEIISGPTSTLMDEILSLRTELLA 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  189 LRRTLKQLRDTYKSLISS-VSRFINPENIHYFRDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIMKTLTILIT 267
Cdd:TIGR00383 187 LRRSLWPLRDVLNFLLRKtHLPIQTEEVREYLRDIYDHILSLLEMIETYRELLSSLMDLYLSLVNNKMNEIMKILTVVST 266

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 325065662  268 ILEPLMLISSFYGMNIEELPFAHSPYGIFVISFLMIGISFFLLYYFRRKGWI 319
Cdd:TIGR00383 267 IFIPLTFIAGIYGMNFKFMPELNWKYGYPAVLIVMAVIALGPLIYFRRKGWL 318
PRK11085 PRK11085
magnesium/cobalt transporter CorA;
220-319 3.64e-06

magnesium/cobalt transporter CorA;


Pssm-ID: 182951  Cd Length: 316  Bit Score: 47.79  E-value: 3.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 220 RDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIMKTLTILITILEPLMLISSFYGMNIEELPFAHSPYGIFVIS 299
Cdd:PRK11085 217 REILRDIESLLPHNESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAI 296

                         90       100
                 ....*....|....*....|
gi 325065662 300 FLMIGISFFLLYYFRRKGWI 319
Cdd:PRK11085 297 ILMILAGLAPYLYFKRKNWL 316
 
Name Accession Description Interval E-value
TmCorA-like cd12822
Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential ...
 38-319 2.85e-87

Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the Thermotoga maritima CorA_like family are found in all three kingdoms of life. It is a functionally diverse family, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213356 [Multi-domain]  Cd Length: 289  Bit Score: 263.28  E-value: 2.85e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  38 WIHLRGIDEQVENFLLKNFKINELSLEDCRSEG-RSKVEVFEDYVFVLMIYF----DGGISRQKKLCIFWGKDFIITIGS 112
Cdd:cd12822    1 WIDLEGPTEEELQLLAEEFGFHPLAIEDALNERqRPKIEEYDDYLFLVLRALrydeEELELETSELSIFLGKNFLVTVHE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 113 RRLF--EETRKNLSLEERPFEQGVERIFWLISSIVADKFKGVTDILEEQADEIEARVFKEQNPELLEDISDLSFEILTLR 190
Cdd:cd12822   81 GPLRliDEVIERLLSDPKLLPKGPDFLLYAILDAIVDSYFPILDELEDRLDELEDEILEEPRREVLRELFALRRELLRLR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 191 RTLKQLRDTYKSLISSVSRFINPENIHYFRDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIMKTLTILITILE 270
Cdd:cd12822  161 RILSPQREVLNRLLRRENELISEELRPYFRDVYDHLERLAELLDSYRDLLSSLLDAYLSLQSNRTNEVMKVLTIITTIFL 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 325065662 271 PLMLISSFYGMNIEELPFAHSPYGIFVISFLMIGISFFLLYYFRRKGWI 319
Cdd:cd12822  241 PLTFITGIYGMNFEYMPELHWPYGYFIVLGIMLLIAGGLLWWFRRKKWL 289
CorA COG0598
Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];
29-319 1.70e-74

Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];


Pssm-ID: 440363 [Multi-domain]  Cd Length: 305  Bit Score: 231.26  E-value: 1.70e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  29 EELLKKSPKWIHLRGIDEQVENFLLKNFKINELSLEDCRSEG-RSKVEVFEDYVFVLM----IYFDGGISRQKKLCIFWG 103
Cdd:COG0598    8 ELLDPEGFVWIDLDGPTDEELEWLAEEFGLHPLALEDALDIEqRPKLEEYDDYLFIVLrtlnYNEEEEELETGPLSIFLG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 104 KDFIITI--GSRRLFEETRKNLSLEERPFEQGVERIFWLISSIVADKFKGVTDILEEQADEIEARVFKEQNPELLEDISD 181
Cdd:COG0598   88 PNFLITVreRPLDAFDDVRERLERGPGLLPRGPDYLLYALLDAIVDRYFPVLEELEDELDELEDELFESPDNELLRRLYR 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 182 LSFEILTLRRTLKQLRDTYKSLISSVSRFINPENIHYFRDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIMKT 261
Cdd:COG0598  168 LRRELVRLRRALAPLREVLSRLLRGESPLISEEDREYLRDVYDHLERLLEMVDSLRERLSGLLDAYLSLISNRQNEIMKV 247

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 325065662 262 LTILITILEPLMLISSFYGMNIEELPFAHSPYGIFVISFLMIGISFFLLYYFRRKGWI 319
Cdd:COG0598  248 LTIIAAIFLPPTFIAGIYGMNFEGMPELDWPYGYPIVLGLMLLIAVLLYLYFKRKGWL 305
TmCorA-like_1 cd12828
Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima ...
 38-319 4.63e-60

Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this subfamily are found in all three kingdoms of life. It is functionally diverse subfamily, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes Methanosarcina mazei CorA which may be involved in transport of copper and/or other divalent metal ions. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213362 [Multi-domain]  Cd Length: 294  Bit Score: 193.80  E-value: 4.63e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  38 WIHLRGI-DEQVENFLLKNFKINELSLED-CRSEGRSKVEVFEDYVFVL--MIYFDGGISRQK--KLCIFWGKDFIITig 111
Cdd:cd12828    4 WINVDGLhDIELIEKLGERFGLHPLVLEDiLNTGQRPKVEEYDDYLFIVlkMLYYDEDTGELEseQVSLILGKNYVIS-- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 112 srrlFEETRKNL--SLEERpFEQGVERI---------FWLISSIVaDKFKGVTDILEEQADEIEARVFKEQNPELLEDIS 180
Cdd:cd12828   82 ----FQERPGDVfdPVRER-LRNGKGRIrkkgadylaYALLDAIV-DNYFPVLEKLGDRIEDLEEELLENPTPETLERIH 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 181 DLSFEILTLRRTLKQLRDTYKSLISSVSRFINPENIHYFRDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIMK 260
Cdd:cd12828  156 KLKRELLFLRRSIWPLREVINRLLRGESPLISEETRPYLRDVYDHTIQVIDTIETYRDMLSGLLDLYLSSVSNRMNEVMK 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 325065662 261 TLTILITILEPLMLISSFYGMNIEELPFAHSPYGIFVISFLMIGISFFLLYYFRRKGWI 319
Cdd:cd12828  236 VLTIISTIFIPLTFIAGIYGMNFEYMPELEWKYGYPAVLGVMLLIALGMLLYFKRKKWL 294
CorA pfam01544
CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx ...
 34-315 6.61e-52

CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli. CorA is virtually ubiquitous in the Bacteria and Archaea. There are also eukaryotic relatives of this protein. The family includes the MRS2 protein from yeast that is thought to be an RNA splicing protein. However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.


Pssm-ID: 460246 [Multi-domain]  Cd Length: 292  Bit Score: 172.88  E-value: 6.61e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662   34 KSPKWIHLRGIDEQVENFLLKNFKINELSLEDC-RSEGRSKVEVFEDYVFVLMIYF----DGGISRQKKLCIFWGKDFII 108
Cdd:pfam01544   2 QGFVWLDLDSPTEAELEWLARTLGLDPLALEDLlDPEERPRVEDYDDYFLLVLPGVnlddSEEADELVTVSILLGDNFLI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  109 TIGSRRL--FEETRKNLSLEERPFeQGVERIFWLISSIVADKFKGVTDILEEQADEIEARVFKEQNPELLEDISDLSFEI 186
Cdd:pfam01544  82 TVRHEPLpaLDEVRKRLTLLGGGP-LDPGDLLYRLLDEIVDRFLELLEKLEDELDELEDELEDETNNELLRELAALRRSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  187 LTLRRTLKQLRDTYKSLISSVSRF-INPENIHYFRDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIMKTLTIL 265
Cdd:pfam01544 161 VYLRRSLLPQRDVLNRLLRREDDPlLDDEQKEYLRDLLDRLERLLEDLDALRERLRSLQDEYSSLLSERTNRVMKVLTVV 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 325065662  266 ITILEPLMLISSFYGMNIEELPFAHSPYGIFVISF--LMIGISFFLLYYFRR 315
Cdd:pfam01544 241 TAIFLPLTLITGIYGMNFGGLPELEWSYGYPFVLIlgLMILLAILLLFYFRR 292
MtCorA-like cd12830
Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the ...
 38-319 1.81e-44

Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213364 [Multi-domain]  Cd Length: 292  Bit Score: 153.45  E-value: 1.81e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  38 WIHLRGIDEQVENFLLKNFKINELSLEDCRSEG-RSKVEVFEDYVFVLM---IYFD-GGISRQKKLCIFWGKDFIITI-- 110
Cdd:cd12830    4 WVGLHEPDAEELAAVAEEFGLHELAVEDAVHAHqRPKLERYGDSLFLVLrtaRYVDhTEEVETGETHVFVGPDFVVTVrh 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 111 GSRRLFEETRKNLSLEERPFEQGVERIFWLISSIVADKFKGVTDILEEQADEIEARVFKEQNPELLEDISDLSFEILTLR 190
Cdd:cd12830   84 GAAGPLARVRARLEADPELLALGPDAVLYAILDFIVDGYLPVAEELEDDVDELEEEVFSPDRRDDIERIYRLKREVLEFR 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 191 RTLKQLRDTYKSLISSVSRFINPENIHYFRDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIMKTLTILITILE 270
Cdd:cd12830  164 RAVDPLVEVLRRLARGHEPLIPKELRPYFRDVADHLLRVADRVDSLRELLSSALQANLALVSVQQNEDMRKISAWAAILA 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 325065662 271 PLMLISSFYGMNIEELPFAHSPYGIFVISFLMIGISFFLLYYFRRKGWI 319
Cdd:cd12830  244 VPTAIAGIYGMNFDHMPELHWTYGYPLVLGLMVAVCLGLYRRFRRNGWL 292
corA TIGR00383
magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp ...
 38-319 2.71e-38

magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp Genomics 1998;3(3):151-69 discusses this family and suggests that some members may have functions other than Mg2+ transport. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273048 [Multi-domain]  Cd Length: 318  Bit Score: 137.90  E-value: 2.71e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662   38 WIHL-RGIDEQVENFLLKNFKINELSLEDCR-SEGRSKVEVFEDYVFVLMIYF-----DGGISRQkkLCIFWGKDFIITI 110
Cdd:TIGR00383  29 WIDLiEPTDEERLAKLGQFFAIHPLALEDILnSPQRPKVEEDEDHLFIISFFLnededDTFETEQ--VSFILGKNLLFTI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  111 GSRRL--FEETRKNLSLEERPFEQGVERIFWLISSIVADKFKGVTDILEEQADEIEARVFKEQNPELLEDISDLSFEILT 188
Cdd:TIGR00383 107 HERELpaFDSIRERIRTSQKVFEKGADYLLYDIFDAIIDSYFPLLENIEDELEELEDEIISGPTSTLMDEILSLRTELLA 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  189 LRRTLKQLRDTYKSLISS-VSRFINPENIHYFRDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIMKTLTILIT 267
Cdd:TIGR00383 187 LRRSLWPLRDVLNFLLRKtHLPIQTEEVREYLRDIYDHILSLLEMIETYRELLSSLMDLYLSLVNNKMNEIMKILTVVST 266

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 325065662  268 ILEPLMLISSFYGMNIEELPFAHSPYGIFVISFLMIGISFFLLYYFRRKGWI 319
Cdd:TIGR00383 267 IFIPLTFIAGIYGMNFKFMPELNWKYGYPAVLIVMAVIALGPLIYFRRKGWL 318
TmCorA-like_u2 cd12831
Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This ...
 49-318 3.00e-38

Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213365 [Multi-domain]  Cd Length: 287  Bit Score: 136.91  E-value: 3.00e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  49 ENFLLKN-FKINELSLEDCRSE-GRSKVEVFEDYVFVLMIYFDGGISRQKKLCIFWGKDFIITIGSRRL--FEETRKNLs 124
Cdd:cd12831   14 EIKLLTSfFHFHPLAIEDCLHLlQRPKLDYYDDYQFLVLHAIDQEDLEAEEVNLFVGENYIVTFHKEPIreINEVWEKL- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 125 LEERPFEQGVERI-FWLISSIVADKFKGVTDIlEEQADEIEARVFKEQNPELLEDISDLSFEILTLRRTLKQLRDTYKSL 203
Cdd:cd12831   93 KEKKDKKLGTLYIaYMIIDKIVDDYFPIVYEI-EDRLNEIEDNNVDSSNKKLMDEVFDIRSDLLKLRRTILPMRDLLYRI 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 204 ISSvSRFINP-ENIHYFRDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIMKTLTILITILEPLMLISSFYGMN 282
Cdd:cd12831  172 LNS-ERLEGDkEQRAYFQDIYDHLLKLSEMLESNREMTADIRDNYESYNSNRMNSIMMTLTIISTIFMPLTFIAGIYGMN 250

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 325065662 283 IEELPFAHSPYGIFVISFLMIGISFFLLYYFRRKGW 318
Cdd:cd12831  251 FEYMPELKWHYGYFVVLGIMLLIAIGMILWFKKKGW 286
TmCorA-like_u3 cd12832
Uncharacterized subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs ...
 38-319 1.92e-34

Uncharacterized subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213366 [Multi-domain]  Cd Length: 287  Bit Score: 126.95  E-value: 1.92e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  38 WIHLRGIDEQVENFLLKNFKINELSLEDCRSEGR-SKVEVFEDYVFVLMIYFDGGISRQ--------KKLCIFWGKDFII 108
Cdd:cd12832    1 WIDVVAPTEEDLEDLARRYNLHETSLKDCLDPDHlPKYEEVDGVTFIILRVYTDKKRENadtiqeltTKIAIFVVDKFVI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 109 TI--GSRRLFEETRKNLsLEERPFEQGVERIFWLISSIVADKFKGVTDILEEQADEIEARVF-KEQNPELLEDISDLSFE 185
Cdd:cd12832   81 TIhrTDLEFIANLKEKW-LSGMHKCESPTELLLRIVKDALKTYEAPLEKLSEELDKYEEEVFlKKRKGSLLKRLYHLKRK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 186 ILTLRRTLKQLRDTYKSLissvsrFINPENIHYFRDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIMKTLTIL 265
Cdd:cd12832  160 ASVIKRVLNLTQDVIDKI------DTPLKSDPYTQDLRDLLIKLLSLYDELHENATNLLSLYISLSSQRTNEVMRVLTIF 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 325065662 266 ITILEPLMLISSFYGMNIEELPFAHSPYGIFVISFLMIGISFFLLYYFRRKGWI 319
Cdd:cd12832  234 SVFFLPLTFIAGVYGMNFKYMPELHWKYGYPATLLVMIVIVVGIYFWFKRKGWL 287
EcCorA_ZntB-like cd12821
Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily ...
 38-318 7.47e-31

Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this family are found in all three kingdoms of life. It is a functionally diverse family, including the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), and the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). It also includes two Saccharomyces cerevisiae members: the inner membrane Mg2+ transporters Mfm1p/Lpe10p, and Mrs2p, and a family of Arabidopsis thaliana members (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213355 [Multi-domain]  Cd Length: 285  Bit Score: 117.42  E-value: 7.47e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  38 WIHLRGIDEQVENFL--LKNFKINELSLEDCRSEGRSKVEVFEDYVFVLMIYFDGGISRQKKLCIFWGKDFIITIGSR-- 113
Cdd:cd12821    1 WYDIDEPDDEIRRLLeeLESSHLPNDLRDILLGVSFPRFEEVSGSGIYIQLRKPQKDADTASFHFLITRDRLITVRLDel 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 114 RLFEETRKNLSLEERPF-EQGVERIFWLISSIVADKFKGVTDIlEEQADEIEARVFKEQNPELLEDISDLSFEILTLRRT 192
Cdd:cd12821   81 PALDELRQDLRSGQMKSaKSAAELLFVLLGAIIKALLTGIDQF-EEKLEELEWDLLEGNNAIKLDRILELRRELLRLTNL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 193 LKQLRDTYKSLISSVSRFINPENIHYFRDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIMKTLTILITILEPL 272
Cdd:cd12821  160 IEPQQEVLMALQEAFAELLFSEDEEELRRTLDRIERLLQLIEEYEQELDTLQDIEEVVSSHRGNEIMKTLTVVTTVFLPL 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 325065662 273 MLISSFYGMNIEELPFAHSPYGIFVISFLMIGISFFLLYYFRRKGW 318
Cdd:cd12821  240 TLIGGLWGMNFKNMPELEWKYGYLFVLGLIILSTAGLYLYLRRKGW 285
EcCorA_ZntB-like_u2 cd12827
uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB ...
 38-319 2.80e-29

uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes.The EcCorA-ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213361 [Multi-domain]  Cd Length: 289  Bit Score: 113.37  E-value: 2.80e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  38 WIHLRGIDEQVENFLLKNFKINELSLEDCR-SEGRSKVEVFEDYVFVLMIY-------FDGGISRQKKLCIFWGKDFIIT 109
Cdd:cd12827    1 WINVVNPTEEEIEQLAEKYGIPEDFLTYALdEEERSRIEYDDDTDYLLIILdvpveeeEDDDEYETIPLGIILTKDRLIT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 110 IGSRR--LFEETRKNLslEERPFEQGVERIFWLISSIVADKFKGVTDILEEQADEIEARVFKEQNPELLEDISDLSFEIL 187
Cdd:cd12827   81 ICNHEtdLLDDFLEGR--VKNFDTSSKTRFLLQILYRIATSYLKYLRQINKERDELEQELRKSTKNKELFQLLDLEKSLV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 188 TLRRTLKQLRDTYKSLISSVSRFINPENIHYFRDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIMKTLTILIT 267
Cdd:cd12827  159 YFSTSLKSNEIVLEKLKRSRSLKLDEEDKELLEDVIIENKQAIEMAEIYSDILSGLMDAFASVISNNLNNVMKFLTSITI 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 325065662 268 ILEPLMLISSFYGMNIeELPFAHSPYGIFVISFLMIGISFFLLYYFRRKGWI 319
Cdd:cd12827  239 VLTIPTIITGFYGMNV-PLPFADSPYAFWIILLISLLLSVIVALILRRKKYF 289
EcCorA_ZntB-like_u1 cd12826
uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB ...
 52-319 3.79e-28

uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. The EcCorA-ZntB_like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB_like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213360  Cd Length: 281  Bit Score: 109.96  E-value: 3.79e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  52 LLKNFKINELSLEDCRSEGRSKVEVFEDYVFVLMIYFDGGISRQKKLCI--FWGKDFIITIG----SRRLFEETRKNLSL 125
Cdd:cd12826   12 LKELFGLKKELLESLESIRFCKAEVFEDCLGGTFGIPDKLDVLGKRDRFgfYITKNRLVFIDddgfVLKLLERIQEKKSW 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 126 EERpfeqGVERIFWLISSIVADKFKGVTDILEEQADEIEARVFKEQNPELLEDISDLSFEILTLRRTLKQLRDTYKSLIS 205
Cdd:cd12826   92 KGP----SLERFLYDFLEYLIKDDLEYLEKYEEKLEELEEEILDGKLKNFNERILKIRKELLRLNSYYEQLMDIGEELEE 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 206 SVSRFINPENIHYFRDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIMKTLTILITILEPLMLISSFYGMNIEE 285
Cdd:cd12826  168 NENDLFDEEELRLFRLFSDRVERLHDNVQMLREYSLQIRELYQSQIDIRQNRIMKILTVVTTIFLPLTLITGWYGMNFTN 247

                        250       260       270
                 ....*....|....*....|....*....|....
gi 325065662 286 LPFAHSPYGIFVISFLMIGISFFLLYYFRRKGWI 319
Cdd:cd12826  248 MPELHWKYGYPVVIILSILIVVIEIIYFKKKKWL 281
ZntB-like_1 cd12833
Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; A bacterial subgroup belonging to ...
 36-319 2.63e-23

Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; A bacterial subgroup belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213367 [Multi-domain]  Cd Length: 290  Bit Score: 97.18  E-value: 2.63e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  36 PKWIHLRGIDEQVENFLLKNFKINELSLED-CRSEGRSKVEVFEDYVFVLM--IYFDGG------ISrqkkLCIFWGKDF 106
Cdd:cd12833    2 FLWLHLDYSDPEAQDWLEQSSGLPELVIDAlLAEETRPRATRLGDGLLLNLrgVNLNPGadpedmVS----IRLWITPGR 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 107 IITIGSRRLF--EETRKNLSLEERPFEQG------VERIFWLISSIVADkfkgvtdiLEEQADEIEARVFKEQNPELLED 178
Cdd:cd12833   78 IISTRRRRLLavDDIREALEAGKGPKSPGdflaalAERLTDRMEDVIDE--------LEDRLDELEERVLEEEDEELRGE 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 179 ISDLSFEILTLRRTLKQLRDTYKSLISSVSRFINPENIHYFRDLLD-------EISILYDRAETLHEftqnvlsVFSSLV 251
Cdd:cd12833  150 LAELRRQAIALRRYLAPQRDALERLAREDLPWLSDDDRLRLREAADrltryieDLDAIRERAAVLQE-------ELTNRR 222

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 325065662 252 SFKLNDIMKTLTILITILEPLMLISSFYGMNIEELPFAHSPYGIFVISFLMIGISFFLLYYFRRKGWI 319
Cdd:cd12833  223 AEQMNRRMYVLSIVAAIFLPLGFLTGLLGINVGGIPGAENPWAFWIFCGLLVVLAVGLLLLFRRKKWL 290
Alr1p-like cd12829
Saccharomyces cerevisiae Alr1p-like subfamily; This eukaryotic subfamily belongs to the ...
 38-316 6.36e-23

Saccharomyces cerevisiae Alr1p-like subfamily; This eukaryotic subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213363 [Multi-domain]  Cd Length: 305  Bit Score: 96.57  E-value: 6.36e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  38 WIHLRGIDEQVENFLLKNFKINELSLEDCRS-EGRSKVEVFEDYVFV---LMIYFDGGISRQKK-----LCIFwgKDFII 108
Cdd:cd12829    1 WLDVQSPTDDDMRAIGKLFPIHPLTLEDILSqDTREKVELFPNYYFIsfrAIESDSELDENVLEpvnvyIVVF--REGIL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 109 TIGSRRL--FEETRKNLSLEERPFEQGVERIFW-LISSIVaDKFKGVTDILEEQADEIEARVFKEQN---PELLEDISDL 182
Cdd:cd12829   79 TFHFKPLdhIERVRKRIRLLSDSHLLSSDWVLYaLLDSIV-DSFFPLVDSIEKEVDSIDELVLLISSsdqSDLLRRIGDL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 183 SFEILTLRRTL-------KQLRdtyKSLISSVSRFINPENIHYFRDLLDEISILYDR---AETLHEFTQNV----LSVFS 248
Cdd:cd12829  158 RRRVTSLLRLLfaksdvlKQLL---KRLMKKTFVSPDSEVAIYLGDVQDHILTLLQKlnhYEDLLSRSHSNylaqLSLEM 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 325065662 249 SLVSFKLNDIMKTLTILITILEPLMLISSFYGMNI-----EELPFAHSPYGIFVISFLMIGISFFllYYFRRK 316
Cdd:cd12829  235 SQESNGTDKAMLRLTVIATIFLPLQLITGLFGMNVkvpgqDIESLYWFFGIVIVAIMVLVAIVVV--FLVRRW 305
MIT_CorA-like cd11744
metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of ...
 38-318 4.38e-21

metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. They are found in most bacteria and archaea, and in some eukaryotes. It is a functionally diverse group which includes the Mg2+ transporters of Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and the Zn2+ transporter Salmonella typhimurium ZntB, which mediates the efflux of Zn2+ (and Cd2+). It includes five Saccharomyces cerevisiae members: i) two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, ii) two mitochondrial inner membrane Mg2+ transporters: Mfm1p/Lpe10p, and Mrs2p, and iii) and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. It also includes a family of Arabidopsis thaliana members (AtMGTs), some of which are localized to distinct tissues, and not all of which can transport Mg2+. Thermotoga maritima CorA and Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, Mrs2p, and Alr1p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213354 [Multi-domain]  Cd Length: 286  Bit Score: 91.11  E-value: 4.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  38 WIHLRGIDEQVENFLLKNFKINELSLEDC-RSEGRSKVEVFEDYVFVLMIYF------DGGISRQKKLCIFWGKDFIITI 110
Cdd:cd11744    1 WIHCERLHDDDIRRVLEDNLHVPRALEDIlLAESRPSFHPLDDNFMIILRGFnmdenaSPEDMLSVRILYFQGALISTRE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 111 GSRRLFEETRKNLSLEERPFEQGVERIFWLISSIVaDKFKGVTDILEEQADEIEARVFKEQNPELLEDISDLSFEILTLR 190
Cdd:cd11744   81 IPSRAFMEIRQRLREHSKGPKSAASLLNQLIEGLN-GKIDLYLETIEETLNELDVNDEEGHYDESTYNHIALQKALISIR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 191 RTLKQLRDTYKSLISSVSRFINpENIHYFRDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIMKTLTILITILE 270
Cdd:cd11744  160 RFIRPQQYALRDLIRSESELVT-SRPHQYRFAHNNITRINETIEFYLGEVALLQDEIKHNRDEKTNKNSKLFTLVATIFL 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 325065662 271 PLMLISSFYGMNIEELPFAHSPYGIFVISFLMIGISFFLLYYFRRKGW 318
Cdd:cd11744  239 PTTFLAGLYGMNFEGMPGVESSMAFTWFCIALIVAFGLEWLLFKRKGF 286
HpCorA-like cd12836
Mg2+ transporter Helicobacter pylori CorA-like subgroup; A bacterial subgroup of the ...
 104-319 4.26e-18

Mg2+ transporter Helicobacter pylori CorA-like subgroup; A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporter Helicobacter pylori CorAs (which can also transport Co2+, and Ni2+); CorA plays an important role in the viability of this pathogen. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB (members of the EcCorA_ZntB-like family) form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213370 [Multi-domain]  Cd Length: 288  Bit Score: 82.69  E-value: 4.26e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 104 KDFIITIGSR--RLFEETRKNLSLEERPFEQGvERIFwliSSIVADKFKGVTDILE---EQADEIEARVFKEQNP--ELL 176
Cdd:cd12836   72 DNILFTIRYGelRTFSETSKKLRANPKKFQTG-YDIF---SSILEIRIDYDADLLEnisKEISKLRKKLFADEDLdeELL 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 177 EDISDLSFEILTLRRTLKQLRDTYKSLISSvsRFINPENIHYFRDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLN 256
Cdd:cd12836  148 EKISRLQELNMTIRENLIDKQRVLSSLLKS--EKFPEDLKENLRIMIKDINSLIEHTTFNFERLDYLQNTFLGLINIEQN 225

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 325065662 257 DIMKTLTILITILEPLMLISSFYGMNIEELPFAHSPYGIFVISFLMIGISFFLLYYFRRKGWI 319
Cdd:cd12836  226 KIIKIFTVATVIFMPPTLIASIYGMNFKFMPELDWKYGYPFALLLMVISSILPLLYFKKKKWL 288
EcCorA-like cd12825
Escherichia coli Mg2+ transporter CorA_like subfamily; A bacterial subfamily of the ...
 104-319 4.06e-13

Escherichia coli Mg2+ transporter CorA_like subfamily; A bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB_like(EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporters Escherichia coli, Salmonella typhimurium, and Helicobacter pylori CorAs (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213359 [Multi-domain]  Cd Length: 287  Bit Score: 68.50  E-value: 4.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 104 KDFIITI--GSRRLFEeTRKNLSLEERPFEQGVERIFWLISSIVADKFKGVTDILEEQADEIEARVFKEQNP--ELLEDI 179
Cdd:cd12825   71 GNILFTIryRDLPAFD-IFPKRAFSQRKFFNSGEELFLFLFEVIVDYLADILENISKKIKQLSREILEEKQFseEDLDAL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 180 SDLSFEILTLRRTLKQLRDTYKSLISSVSrfINPENIHYFRDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIM 259
Cdd:cd12825  150 TKLNENNITLRESLIEKQRIITLLLKSPR--ENSDTKEKLKIELRDLSSLLDHTTFNFDKLDDLKNNILGKIELEQNKII 227

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 260 KTLTILITILEPLMLISSFYGMNIEELPFAHSPYGIFVISFLMIGISFFLLYYFRRKGWI 319
Cdd:cd12825  228 KIFTVVTVCFLPPTLIASIYGMNFKNMPELKWSYGYPFALILMILSTILPLLYFKRKGWL 287
EcCorA-like_1 cd12835
Escherichia coli Mg2+ transporter CorA_like subgroup; A bacterial subgroup of the Escherichia ...
 134-319 6.60e-12

Escherichia coli Mg2+ transporter CorA_like subgroup; A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporters Escherichia coli CorA and Salmonella typhimurium CorA (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213369  Cd Length: 287  Bit Score: 64.97  E-value: 6.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 134 VERIFWLISSIVADKFKGVTDILEE---QADEIEARVFKEQNPELLEDISDLSFEILTLRRTLKQLRDTYKSLiSSVSRF 210
Cdd:cd12835   98 VSDPKDLLLDLFEQKVEYLADIIEDiyrDLERVSREVLEENDEDLEEALGRLARQEDLNGKIRLCLMDTQRAL-SFLLRT 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 211 INPENIHyfRDLLDEIsiLYDrAETLHEFTQNV-------LSVFSSLVSFKLNDIMKTLTILITILEPLMLISSFYGMNI 283
Cdd:cd12835  177 RRLSDEQ--LEDAREI--LRD-IESLLPHTQFLfdkinflMDAAMGFINIEQNKIIKIFSVAAVVFLPPTLIASIYGMNF 251

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 325065662 284 EELPFAHSPYGIFVISFLMIGISFFLLYYFRRKGWI 319
Cdd:cd12835  252 DFMPELDWKFGYPMAIGLMILSAIAPYLYFKRKGWL 287
ZntB-like cd12824
Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; A bacterial subfamily belonging ...
 38-317 5.26e-11

Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; A bacterial subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213358 [Multi-domain]  Cd Length: 290  Bit Score: 62.15  E-value: 5.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662  38 WIHLRGIDEQVENFLLKNFKINELSLEDCRS-EGRSKVEVFEDYVFVLM--IYFD--GGISRQKKLCIFWGKDFIITI-- 110
Cdd:cd12824    4 WYHCDRADPAIRSWLEDNTHLPEATVDHLLApVRFPHFEPVDDGFLLSLrgIRMDeaASPSDMADLRILIGQGAAVTVrs 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 111 GSRRLFEETRKNLSlEERPFEQGVERIFWLISSIVaDKFKGVTDILEEQADEIEARVFKEQNPELLEDISDLSFEILTLR 190
Cdd:cd12824   84 GPSRAVDELRRALR-DHSSLKSLADLLAQMISGMT-KRLELVIFDLTETLDEVEDNLLDGGTAPPPYALIALQRRLFRIR 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 191 RTLKQLRDTYKSLISSVSRFINPENIHYFRDLLDEISILYdraETLhEFTQNVLSVFSSLVSFKLNDIMK----TLTILI 266
Cdd:cd12824  162 RQIRPQQQALRPLITDPAELLVTSDRETLRRASNNVTRYL---ETL-DFCRTRVALLQDEIKAQRDEKTTrsslLLTVVA 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 325065662 267 TILEPLMLISSFYGMNIEELPFAHSPYGIFVISFLMIGISFFLLYYFRRKG 317
Cdd:cd12824  238 TVFLPLTFITGLLGMNVGGIPDVESPMGFWWVTGLSILVALLAWLLLRRLG 288
ZntB_u1 cd12834
Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like ...
 145-317 6.88e-11

Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; The MIT superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. The ZntB-like subfamily includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213368 [Multi-domain]  Cd Length: 290  Bit Score: 61.83  E-value: 6.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 145 VADKFKGVTDILEEQADEIEARVfkeqnpeLLEDISDLSFEILTLRRTLKQLRdtykslissvsRFINPENIHYFRDLLD 224
Cdd:cd12834  116 QADTLSRIVRELTDELDRIEDRL-------LSGRLRRERRELGALRRRLVRLH-----------RLLAPEPAALFRLLRR 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 225 EISILYDRA-ETLHEFTQNVLSVFSSLVSF----KL-------------NDIMKTLTILITILEPLMLISSFYGMNIEEL 286
Cdd:cd12834  178 PPDWLPDADlETLRRLTERLDALDRDLVALqeraRLlqeeiaarlaeqtNRSLYILSVVTALLLPPTLVTGLFGMNTGGL 257

                        170       180       190
                 ....*....|....*....|....*....|.
gi 325065662 287 PFAHSPYGIFVISFLMIGISFFLLYYFRRKG 317
Cdd:cd12834  258 PLAEGPHGFWIAVALALLAAGLAYLLLRRLG 288
EcCorA-like_u1 cd12837
uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; A ...
 154-319 6.13e-10

uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; A uncharacterized subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. The EcCorA_ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA_ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213371 [Multi-domain]  Cd Length: 298  Bit Score: 59.08  E-value: 6.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 154 DILEEQADEIEA---RVFkEQNPELLEDISDlsfeilTLRRTLKQL----------RDtykSLISsVSRFINpenihYFR 220
Cdd:cd12837  120 DVLERVGADLDRlsrRIF-RSSAKRRRRASR------DLRSVLRRIgragdllskiRE---SLLS-LGRLLS-----FLS 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 221 DLLDEISI--LYDRAETLHEFTQNvLSVF----SSLVSFKL-----------NDIMKTLTILITILEPLMLISSFYGMNI 283
Cdd:cd12837  184 ANAADWLSkeLRARLKTLQRDVAS-LSEHatflSNKIQFLLdatlglinieqNNIIKIFSVASVVFLPPTLIASIYGMNF 262

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 325065662 284 EELPFAHSPYGiFVISFLMIGISFFL-LYYFRRKGWI 319
Cdd:cd12837  263 KHMPELDWPFG-YPLALGLMVLSAVLpLLWFKRRGWL 298
PRK11085 PRK11085
magnesium/cobalt transporter CorA;
220-319 3.64e-06

magnesium/cobalt transporter CorA;


Pssm-ID: 182951  Cd Length: 316  Bit Score: 47.79  E-value: 3.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 220 RDLLDEISILYDRAETLHEFTQNVLSVFSSLVSFKLNDIMKTLTILITILEPLMLISSFYGMNIEELPFAHSPYGIFVIS 299
Cdd:PRK11085 217 REILRDIESLLPHNESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAI 296

                         90       100
                 ....*....|....*....|
gi 325065662 300 FLMIGISFFLLYYFRRKGWI 319
Cdd:PRK11085 297 ILMILAGLAPYLYFKRKNWL 316
Mrs2_Mfm1p-like cd12823
Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like ...
 229-318 3.88e-04

Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family; A eukaryotic subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This functionally diverse subfamily includes the inner mitochondrial membrane Mg2+ transporters Saccharomyces cerevisiae Mfm1p/Lpe10p, Mrs2p, and human MRS2/ MRS2L. It also includes a family of Arabidopsis thaliana proteins (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of two EcCorA_ZntB-like family transporters: Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213357  Cd Length: 323  Bit Score: 41.46  E-value: 3.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325065662 229 LYDRAETLHEFTQNVLSVFSSLVSFKLNDIMK---TLTILITILEPLMLISSFYGMNIeELPFAHSPYGIFVISFLMIGI 305
Cdd:cd12823  228 LLNKLEELREYIDDTEELINLILDSRRNQLMRlelKLSIGTLSLAVGTLVAGLFGMNL-PSGLEESPYAFWIVTGGSVVG 306

                         90
                 ....*....|....*..
gi 325065662 306 SFFL----LYYFRRKGW 318
Cdd:cd12823  307 SILIfivvLRYLRRKRL 323
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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