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Conserved domains on  [gi|324313899|gb|ADY34452|]
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protein of unknown function DUF1573 [Odoribacter splanchnicus DSM 20712]

Protein Classification

DUF1573 domain-containing protein( domain architecture ID 10541252)

DUF1573 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF1573 pfam07610
Protein of unknown function (DUF1573); These hypothetical proteins, from bacteria such as ...
 43-139 7.99e-43

Protein of unknown function (DUF1573); These hypothetical proteins, from bacteria such as Rhodopirellula baltica, Bacteroides thetaiotaomicron, and Porphyromonas gingivalis, share a region of conserved sequence towards their N-termini.


:

Pssm-ID: 429559  Cd Length: 98  Bit Score: 136.49  E-value: 7.99e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324313899   43 IRFERDTLQLGTIRYGEKRKVTFRFTNTGQTPLLLRDVRPSCGCTGAEWEKRPVAPGETGEIKITFDPNS-LGHFLKNID 121
Cdd:pfam07610   1 ITFEETTIDFGTIEEGGPVTHTFTFTNTGKAPLVITDVRTSCGCTTPEWPKEPIAPGETGKIKVTFDAKGrPGHFNKTIT 80

                          90
                  ....*....|....*...
gi 324313899  122 IVCNIDSGIMKLKLCGNV 139
Cdd:pfam07610  81 VYSNASPGPVTLTIKGNV 98
 
Name Accession Description Interval E-value
DUF1573 pfam07610
Protein of unknown function (DUF1573); These hypothetical proteins, from bacteria such as ...
 43-139 7.99e-43

Protein of unknown function (DUF1573); These hypothetical proteins, from bacteria such as Rhodopirellula baltica, Bacteroides thetaiotaomicron, and Porphyromonas gingivalis, share a region of conserved sequence towards their N-termini.


Pssm-ID: 429559  Cd Length: 98  Bit Score: 136.49  E-value: 7.99e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324313899   43 IRFERDTLQLGTIRYGEKRKVTFRFTNTGQTPLLLRDVRPSCGCTGAEWEKRPVAPGETGEIKITFDPNS-LGHFLKNID 121
Cdd:pfam07610   1 ITFEETTIDFGTIEEGGPVTHTFTFTNTGKAPLVITDVRTSCGCTTPEWPKEPIAPGETGKIKVTFDAKGrPGHFNKTIT 80

                          90
                  ....*....|....*...
gi 324313899  122 IVCNIDSGIMKLKLCGNV 139
Cdd:pfam07610  81 VYSNASPGPVTLTIKGNV 98
COG1470 COG1470
Uncharacterized membrane protein [Function unknown];
54-112 3.01e-03

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 441079 [Multi-domain]  Cd Length: 475  Bit Score: 36.38  E-value: 3.01e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 324313899  54 TIRYGEKRKVTFRFTNTGQTPlLLRDVRPSC-GCTGAEWEKRP-----VAPGETGEIKITFDPNS 112
Cdd:COG1470  215 TVTPGESATFTVTVTNTGNGA-DLTNVTLSAsAPSGWTVSFEPetipsLAPGESATVTLTVTVPA 278
 
Name Accession Description Interval E-value
DUF1573 pfam07610
Protein of unknown function (DUF1573); These hypothetical proteins, from bacteria such as ...
 43-139 7.99e-43

Protein of unknown function (DUF1573); These hypothetical proteins, from bacteria such as Rhodopirellula baltica, Bacteroides thetaiotaomicron, and Porphyromonas gingivalis, share a region of conserved sequence towards their N-termini.


Pssm-ID: 429559  Cd Length: 98  Bit Score: 136.49  E-value: 7.99e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 324313899   43 IRFERDTLQLGTIRYGEKRKVTFRFTNTGQTPLLLRDVRPSCGCTGAEWEKRPVAPGETGEIKITFDPNS-LGHFLKNID 121
Cdd:pfam07610   1 ITFEETTIDFGTIEEGGPVTHTFTFTNTGKAPLVITDVRTSCGCTTPEWPKEPIAPGETGKIKVTFDAKGrPGHFNKTIT 80

                          90
                  ....*....|....*...
gi 324313899  122 IVCNIDSGIMKLKLCGNV 139
Cdd:pfam07610  81 VYSNASPGPVTLTIKGNV 98
ASH pfam15780
Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin; The ASH domain or N-terminal ...
 49-114 2.41e-03

Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin; The ASH domain or N-terminal domain of abnormal spindle-like microcephaly-associated protein are found in proteins associated with cilia, flagella, the centrosome and the Golgi complex. The domain is also found in Hydin and OCRL whose deficiencies are associated with hydrocephalus and Lowe oculocerebrorenal syndrome (OCRL), respectively. The fact that Human ASPM protein carries an ASH domain indicates possible roles for ASPM in sperm flagellar or in ependymal cells' cilia. The presence of ASH in centrosomal and ciliary proteins indicates that ASPM may possess roles not only in mitotic spindle regulation, but also in ciliary and flagellar function.


Pssm-ID: 464865 [Multi-domain]  Cd Length: 98  Bit Score: 35.33  E-value: 2.41e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 324313899   49 TLQLGTIRYGEKRKVTFRFTNTGQTPLLL---RDVRPSCGCTgAEWEKRPVAPGETGEIKITFDPNSLG 114
Cdd:pfam15780  13 FVCFGDVPVGTSAERLLTVVNPSEEPAEVkvsKVPAPTKGFS-VSPLEFTVQPGESQTLTVTWTPTEEG 80
COG1470 COG1470
Uncharacterized membrane protein [Function unknown];
54-112 3.01e-03

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 441079 [Multi-domain]  Cd Length: 475  Bit Score: 36.38  E-value: 3.01e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 324313899  54 TIRYGEKRKVTFRFTNTGQTPlLLRDVRPSC-GCTGAEWEKRP-----VAPGETGEIKITFDPNS 112
Cdd:COG1470  215 TVTPGESATFTVTVTNTGNGA-DLTNVTLSAsAPSGWTVSFEPetipsLAPGESATVTLTVTVPA 278
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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