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Conserved domains on  [gi|321173431|gb|ADW77484|]
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POU domain transcription factor OCT4-pg4 [Homo sapiens]

Protein Classification

POU family transcription factor( domain architecture ID 11265437)

POU (Pit-Oct-Unc) family transcription factor binds specific DNA sequences to direct gene expression programs, playing a role in orchestrating embryonic development and directing cellular fate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
131-205 2.28e-44

Found in Pit-Oct-Unc transcription factors;


:

Pssm-ID: 197673  Cd Length: 75  Bit Score: 145.27  E-value: 2.28e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 321173431   131 DIKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEGLQLSFKNMCKLRPLLQKWVEEAD 205
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Homeodomain pfam00046
Homeodomain;
224-280 2.20e-17

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 74.07  E-value: 2.20e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 321173431  224 KRKRTSIENRVRGNLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRCQKGKQ 280
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
131-205 2.28e-44

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 145.27  E-value: 2.28e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 321173431   131 DIKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEGLQLSFKNMCKLRPLLQKWVEEAD 205
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
136-205 1.99e-41

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 137.41  E-value: 1.99e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321173431  136 QKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEGLQLSFKNMCKLRPLLQKWVEEAD 205
Cdd:pfam00157   3 LEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
224-280 2.20e-17

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 74.07  E-value: 2.20e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 321173431  224 KRKRTSIENRVRGNLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRCQKGKQ 280
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 223-274 4.46e-13

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 62.65  E-value: 4.46e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 321173431   223 RKRKRTSIENRVRGNLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNR 274
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNR 52
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 224-274 8.50e-12

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 59.18  E-value: 8.50e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 321173431 224 KRKRTSIENRVRGNLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNR 274
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNR 51
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
201-283 2.04e-03

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 37.80  E-value: 2.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321173431 201 VEEADNN---ENLQETCKaetlLQARKRKRTSIENRVRgnLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRCQK 277
Cdd:COG5576   32 VEAADSEmklERKQDGSS----PPKSKRRRTTDEQLMV--LEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAK 105


                 ....*.
gi 321173431 278 GKQSSS 283
Cdd:COG5576  106 EKKKRS 111
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
137-181 4.32e-03

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 35.36  E-value: 4.32e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 321173431 137 KELEQFAKLLKQKRITLGYTQADVGLTLGVlfgkvfSQTTICRFE 181
Cdd:COG1396    3 TLKKALGERLRELRKARGLTQEELAERLGV------SRSTISRIE 41
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
131-205 2.28e-44

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 145.27  E-value: 2.28e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 321173431   131 DIKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEGLQLSFKNMCKLRPLLQKWVEEAD 205
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
136-205 1.99e-41

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 137.41  E-value: 1.99e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321173431  136 QKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEGLQLSFKNMCKLRPLLQKWVEEAD 205
Cdd:pfam00157   3 LEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
224-280 2.20e-17

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 74.07  E-value: 2.20e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 321173431  224 KRKRTSIENRVRGNLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRCQKGKQ 280
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 223-274 4.46e-13

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 62.65  E-value: 4.46e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 321173431   223 RKRKRTSIENRVRGNLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNR 274
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNR 52
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 224-274 8.50e-12

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 59.18  E-value: 8.50e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 321173431 224 KRKRTSIENRVRGNLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNR 274
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNR 51
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
201-283 2.04e-03

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 37.80  E-value: 2.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 321173431 201 VEEADNN---ENLQETCKaetlLQARKRKRTSIENRVRgnLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRCQK 277
Cdd:COG5576   32 VEAADSEmklERKQDGSS----PPKSKRRRTTDEQLMV--LEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAK 105


                 ....*.
gi 321173431 278 GKQSSS 283
Cdd:COG5576  106 EKKKRS 111
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
137-181 4.32e-03

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 35.36  E-value: 4.32e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 321173431 137 KELEQFAKLLKQKRITLGYTQADVGLTLGVlfgkvfSQTTICRFE 181
Cdd:COG1396    3 TLKKALGERLRELRKARGLTQEELAERLGV------SRSTISRIE 41
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
140-181 5.15e-03

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 34.82  E-value: 5.15e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 321173431 140 EQFAKLLKQKRITLGYTQADVGLTLGVlfgkvfSQTTICRFE 181
Cdd:COG1476    3 KKLGNRLKELRKERGLTQEELAELLGV------SRQTISAIE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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