|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
14-451 |
1.69e-126 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 376.14 E-value: 1.69e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 14 EALALWALVLPIVVQMGSQQFMVATDLLFLGHLGRSELAVGSLCTTIFNLLWFGVA-GFGTGFDTLGSQAQGAADFAAVR 92
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILlGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 93 QWAFLAAAFLTACCVPAAIVLSCGESIARTiLSQDEYTSERVGRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKPVAWTSF 172
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLL-LGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 173 ATFLLNIALNVLFIRIMNLGLNGSALATTTSRVVNLILVAAYLRFSDQWSAGalTEVWRTTTPCMCKRMFELGSRGAVMV 252
Cdd:cd13132 160 VALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKAT--WGGFSREAFRGWGPFLKLAIPSALML 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 253 AAEASSFDVTVVFASQI-SQVAMNAHMAMLNITGLTFMTgPMAFGIAANVRVGNLLGAGSGFRAKVASRVSVALGVTWMA 331
Cdd:cd13132 238 CLEWWAFEILVLLAGLLpGTVALAAQSICLTTTSLLYMI-PLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 332 CMAALILIFRRQTGEVFVGDKdnEMVMLAAKIAPIAAVFQVFDGLLGTSNGVLRACGRQALLAWMNIIALWLVGVLSGYV 411
Cdd:cd13132 317 VVAILLLVLRDVWAYLFTSDE--EVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLL 394
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 226517442 412 ITFLLKAGVIGLWYGLALGVTVGGVVLFLIVTRLDWDVEV 451
Cdd:cd13132 395 LAFVLGLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEA 434
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
14-447 |
1.11e-62 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 210.82 E-value: 1.11e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 14 EALALWALVLPIVVQMGSQQFMVATDLLFLGHLGRSELAVGSLCTTIFNLLWFGVAGFGTGFDTLGSQAQGAADFAAVRQ 93
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 94 WAFLAAAFLTACCVPAAIVLSCGESIaRTILSQDEYTSERVGRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKPVAWTSFA 173
Cdd:cd13131 81 AVRQGLWLALLLSLPLMLLLWLAPPI-LPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 174 TFLLNIALNVLFIR----IMNLGLNGSALATTTSRVVNLILVAAYLRFSDQWSAGALTEVWRTTTPCMCKRMFELGSRGA 249
Cdd:cd13131 160 ALVLNIPLNYVLIFgkfgLPALGGAGAGLATAIVYWLMFLALAFYIRRHKRFRRYRLFARFWRPDWARLKELLRLGLPIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 250 VMVAAEASSFDVTVVFASQISQVAMNAHMAMLNITGLTFMtGPMAFGIAANVRVGNLLGAGSGFRAKVASRVSVALGVTW 329
Cdd:cd13131 240 LTIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLLFM-VPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVGF 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 330 MACMAALILIFRRQTGEVFVgdKDNEMVMLAAKIAPIAAVFQVFDGLLGTSNGVLRACGRQALLAWMNIIALWLVGVLSG 409
Cdd:cd13131 319 AALTALLLLLFPEQIAGLYT--NDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLPLG 396
|
410 420 430
....*....|....*....|....*....|....*...
gi 226517442 410 YVITFLLKAGVIGLWYGLALGVTVGGVVLFLIVTRLDW 447
Cdd:cd13131 397 YLLAFTTGLGAFGVWIGLIIGLALAAILLLWRFRRLQR 434
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
8-441 |
1.54e-57 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 197.29 E-value: 1.54e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 8 GSIWRsealALWALVLPIVVQMGSQQFMVATDLLFLGHLGRSELAVGSLCTTIFNLLWFGVAGFGTGFDTLGSQAQGAAD 87
Cdd:COG0534 4 GPILK----LLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 88 FAAVRQWAFLAAAFLTACCVP-AAIVLSCGESIARtILSQDEYTSERVGRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKP 166
Cdd:COG0534 80 REEARRVLGQALLLALLLGLLlTLLGLLFAPPLLR-LLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 167 VAWTSFATFLLNIALNVLFIRIMNLGLNGSALATTTSRVVNLILVAAYLRFSDQWSAGALTEVWRTTTpcMCKRMFELGS 246
Cdd:COG0534 159 PMIIMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRK--ILKRILRIGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 247 RGAVMVAAEASSFDVTVVFASQISQVAMNAHMAMLNITGLTFMTgPMAFGIAANVRVGNLLGAGSGFRAKVASRVSVALG 326
Cdd:COG0534 237 PAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMP-ALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 327 VTWMACMAALILIFRRQTGEVFVgdKDNEMVMLAAKIAPIAAVFQVFDGLLGTSNGVLRACGRQALLAWMNIIALWLVGV 406
Cdd:COG0534 316 LGIGLLLALLLFLFPEPIIGLFT--DDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRL 393
|
410 420 430
....*....|....*....|....*....|....*
gi 226517442 407 LSGYVITFLLkAGVIGLWYGLALGVTVGGVVLFLI 441
Cdd:COG0534 394 PLAYLLAFLG-LGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
17-447 |
2.59e-41 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 153.44 E-value: 2.59e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 17 ALWALVLPIVVQMGSQQFMVATDLLFLGHLGRSELAVGSLCTTIFNLLWFGVAGFGTGFDTLGSQAQGAADFAAVRQWAF 96
Cdd:cd13137 2 RIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 97 LAAAFLTACCVPAAIV-LSCGESIARtILSQDEYTSERVGRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKPVAWTSFATF 175
Cdd:cd13137 82 QSLLLALLLSLPLALLgLLFAEPLLR-LLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 176 LLNIALNVLFI----RIMNLGLNGSALATTTSRVVNLILVAAYLRFsdQWSAGALTEVWRTTTPCMCKRMFELGSRGAVM 251
Cdd:cd13137 161 VLNIVLDYVLIfglwGFPGLGVAGAALATVISRVVGALLLLFLLLR--GRLPIKISFKGFRLDRKIIKKLLRIGLPAGLE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 252 VAAEASSFDVTVVFASQISQVAMNAHMAMLNITGLTFMTGpMAFGIAANVRVGNLLGAGSGFRAKVASRVSVALGVTWMA 331
Cdd:cd13137 239 QLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPG-FGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 332 CMAALILIFRRQTGEVFVgdKDNEMVMLAAKIAPIAAVFQVFDGLLGTSNGVLRACGRQALLAWMNIIALWLVGVLSGYV 411
Cdd:cd13137 318 LLGLLLFIFAPPLASLFT--PDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYL 395
|
410 420 430
....*....|....*....|....*....|....*.
gi 226517442 412 ITFLLKAGVIGLWYGLALGVTVGGVVLFLIVTRLDW 447
Cdd:cd13137 396 LGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKW 431
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
18-447 |
9.26e-36 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 138.43 E-value: 9.26e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 18 LWALVLPIVVQMGSQQFMVATDLLFLGHLGRSELAVGSLCTTIFNLLWFGVAGFGTGFDTLGSQAQGAADFAAVRQWAFL 97
Cdd:cd13133 7 ILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVLWQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 98 AAAFLTACCVPAAIVLSCGESIARTILSQDEYTSERVGRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKPVAWTSFATFLL 177
Cdd:cd13133 87 GLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMVVV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 178 NIALNVLFI----RIMNLGLNGSALATTTSRVVNLILVAAYLRFSDQWSAGALTEVWRTTtPCMCKRMFELGSRGAVMVA 253
Cdd:cd13133 167 NIVLDYALIfgklGFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRFGLRRAWRFD-RELLRRILRLGLPSGLQFF 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 254 AEASSFDVTVVFASQISQVAMNAHMAMLNITGLTFMTGpMAFGIAANVRVGNLLGAGSGFRAKVASRVSVALGVTWMACM 333
Cdd:cd13133 246 LDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPM-IGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLLL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 334 AALILIFRRQTGEVFVGDKDNEMVMLAAKIA-PIAAVFQVFDGLLGTSNGVLRACGRQALLAWMNIIALWLVGVLSGYVI 412
Cdd:cd13133 325 GILFLLFPELLLSIFTPGADFALIAELAVPLlRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPPAYLL 404
|
410 420 430
....*....|....*....|....*....|....*
gi 226517442 413 TFlLKAGVIGLWYGLALGVTVGGVVLFLIVTRLDW 447
Cdd:cd13133 405 VV-LGAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
24-368 |
1.07e-35 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 135.84 E-value: 1.07e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 24 PIVVQMGSQQFMVATDLLFLGHLGRSELAVGSLCTTIFNLLWFGVAGFGTGFDTLGSQAQGAADFAAVRQWAFLAAAFLT 103
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 104 ACCVPAAIVLSCGESIARTILSQDEYTSERVGRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKPVAWTSFATFLLNIALNV 183
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILNY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 184 LFI--RIMNLGLNGSALATTTSRVVNLILVAAYLRFSDQWSAGAltEVWRTTTPCMCKRMFELGSRGAVMVAAEASSFDV 261
Cdd:TIGR00797 161 ILIfgKFGFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKW--EGLLKPDWEVLKRLLKLGLPIAFRVILESLSFAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 262 TVVFASQISQVAMNAHMAMLNITGLTFMTgPMAFGIAANVRVGNLLGAGSGFRAKVASRVSVALGVTWMACMAALILIFR 341
Cdd:TIGR00797 239 LALLVARLGSIALAAHQIALNVESLLFMP-AFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317
|
330 340
....*....|....*....|....*..
gi 226517442 342 RQTGEVFvgDKDNEMVMLAAKIAPIAA 368
Cdd:TIGR00797 318 EFIARLF--TNDPEVLELAAIYLIFVA 342
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
23-442 |
6.74e-32 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 127.05 E-value: 6.74e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 23 LPIVVQMGSQQFMVATDLLFLGHLGRSELAVGSLCTTIFNLLWFGVAGFGTGFDTLGSQAQGAADFAAVRQWAFLAAAFL 102
Cdd:cd12082 2 APLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 103 TACCVPAAIVLSCGESIARTILSQDEYTSERVGRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKPVAWTSFATFLLNIALN 182
Cdd:cd12082 82 ILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILLD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 183 VLFIRIM---NLGLNGSALATTTSRVVNLILVAAYLRFSDQWsAGALTEVWRTTTPCMcKRMFELGSRGAVMVAAEASSF 259
Cdd:cd12082 162 PLLIFGLgppELGIAGAALATVISYVIGALLLLIYLRKGKKI-LKFKLSLLKPDLELL-RRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 260 DVTVVFASQI-SQVAMNAHMAMLNITGLTFMTgPMAFGIAANVRVGNLLGAGSGFRAKVASRVSVALGVTWMACMAALIL 338
Cdd:cd12082 240 LIIVAIVAAFgGAAALAAYTVAFRIASLAFMP-ALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLIL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 339 IFRRQTGEVFVgdKDNEMVMLAAKIAPIAAVFQVFDGLLGTSNGVLRACGRQALLAWMNIIALWLVGVLSGYVITFlLKA 418
Cdd:cd12082 319 LFPEPILSLFT--NDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAY-LGL 395
|
410 420
....*....|....*....|....
gi 226517442 419 GVIGLWYGLALGVTVGGVVLFLIV 442
Cdd:cd12082 396 GLYGIWLALVISLILAALVLLLFF 419
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
11-447 |
1.96e-31 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 126.47 E-value: 1.96e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 11 WRSEALALWALVLPIVVQMGSQQFMVATDLLFLGHLGRSELAVGSLCTTIFNLLWFGVAGFGTGFDTLGSQAQGAADFAA 90
Cdd:PRK01766 7 YKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIWLPVILFGHGLLLALTPIVAQLNGAGRRER 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 91 VRQWAFLAAAFLTACCVPAAIVLSCGESIARTILSQDEYTSERVGRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKPVAWT 170
Cdd:PRK01766 87 IAHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTMVI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 171 SFATFLLNIALNVLFI----RIMNLGLNGSALATTTSRVVNLILVAAYLRFSDQWSAGALTEVWRTTTPCMCKRMFELGS 246
Cdd:PRK01766 167 GFLGLLINIPLNYIFIygkfGFPELGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDFRLFKGLYKPDWAVIKRLLKLGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 247 RGAVMVAAEASSFDVTVVFASQISQVAMNAHMAMLNITGLTFMTgPMAFGIAANVRVGNLLGAGSGFRAKVASRVSVALG 326
Cdd:PRK01766 247 PIGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIALNFSSLLFML-PLSLAMALTIRVGFELGAGRTLDARQYAYIGLAVG 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 327 VTWMACMAALILIFRRQTGEVFVgdKDNEMVMLAAKIAPIAAVFQVFDGLLGTSNGVLRACGRQALLAWMNIIALWLVGV 406
Cdd:PRK01766 326 LGMALLTAIFLVLFREQIALLYT--DDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWVLGL 403
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 226517442 407 LSGYVITFLLKAGVIGLWYGLALGVTVGGVVLFLivtRLDW 447
Cdd:PRK01766 404 PLGYILALTDPMGPFGFWIGLIIGLTAAAILLLL---RLRK 441
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
18-440 |
2.05e-28 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 117.22 E-value: 2.05e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 18 LWALVLPIVVQMGSQQFMVATDLLFLGHLGRSELAVGSLCTTIFNLLWFGVAGFGTGFDTLGSQAQGAADFAAVRQwafl 97
Cdd:cd13134 5 LFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQ---- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 98 AAAFLTACCVPAAIVLSCGESI-ARTILSQDEYTSERVGRFCT-LLIVGLFAAAWTL--VMQKFLQVRGVVKPVAWTSFA 173
Cdd:cd13134 81 IAGVALLFNLLLGLVFSLLLLFfGAELLRLMGLPPELLALGSTyLRIVGGSLFLQALslTLSAILRSHGRTKIPMYVSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 174 TFLLNIALNVLFI----RIMNLGLNGSALATTTSRVVNLILVAAYLRFSDQWSAGalTEVWRTTTPCMCKRMFELGsrga 249
Cdd:cd13134 161 MNILNIVGNYLLIfgwfGLPKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFR--LKDLRPFPKKLLKKILKIG---- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 250 VMVAAEASSFD----VTVVFASQISQVAMNAHMAMLNITGLTFMTGpMAFGIAANVRVGNLLGAGSGFRAKVASRVSVAL 325
Cdd:cd13134 235 LPSAGEELSYNlsqtVITAFIARLGTAALAARTYASNISMFVFLFS-LAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKI 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 326 GVTWMACMAALILIFRRQTGEVFVgdKDNEMVMLAAKIAPIAAVFQVFDGLLGTSNGVLRACGRQALLAWMNIIALWLVG 405
Cdd:cd13134 314 GLLVSLAVALLLALFREPILGLFT--DDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGIS 391
|
410 420 430
....*....|....*....|....*....|....*
gi 226517442 406 VLSGYVITFLLKAGVIGLWYGLALGVTVGGVVLFL 440
Cdd:cd13134 392 VPLAYLLGIVLGLGLLGVWIAFAADEWVRGIIMLW 426
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-447 |
7.51e-28 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 115.75 E-value: 7.51e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 8 GSIWRSealaLWALVLPIVVQMGSQQFMVATDLLFLGHLGRSELAVGSLcttIFNLLWFGVAgFGTGFDTLG----SQAQ 83
Cdd:cd13142 7 GSILRT----LLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSI---SWPLIFLFIS-LGGGLTVAGtalvAQYT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 84 GAADFAAVRQWAFLAAAFLTACCVPAAIVlscGESIARTILSQDEYTSERV----GRFCTLLIVGLFAAAWTLVMQKFLQ 159
Cdd:cd13142 79 GAGDYDKANKVAGQTFSFVIILSLILAVL---GYILSRPLLLLLIGAPEEVyplaLAYLRIIFLGLPFMFIFFVFNSLLR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 160 VRGVVKPVAWTSFATFLLNIALNVLFI----RIMNLGLNGSALATTTSRVVNLIlVAAYLRFSDQWsagALTEVWRTTTP 235
Cdd:cd13142 156 GIGDTKTPMKIMFGSVLLNVILDPLLIfgigPFPGLGVAGAALATVISRGIAAV-IGLYLLFKGRV---GLKISLRDLKP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 236 --CMCKRMFELGSRGAVMVAAEASSFDVTVVFASQISQVAMNAHMAMLNITGLTFMTGpMAFGIAANVRVGNLLGAGSGF 313
Cdd:cd13142 232 dwEWLKKIFRIGLPSSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPA-FGLARATSTMVGQNLGAGQID 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 314 RAKVASRVSVALGVTWMACMAALILIFRRQTGEVFVGDkdNEMVMLAAKIAPIAAVFQVFDGLLGTSNGVLRACGRQALL 393
Cdd:cd13142 311 RAEEIVKKAALLIFLILVIGGVLAFLFAEPIVRVFIND--PEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTA 388
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 226517442 394 AWMNIIALWLVGVLSGYVITFLLKAGVIGLWYGLALGVTVGGVVLFLIVTRLDW 447
Cdd:cd13142 389 MIISILRLWVIRIPLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTW 442
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
12-440 |
3.54e-27 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 114.07 E-value: 3.54e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 12 RSEALALWALVLPIVVQMGSQQFMVATDLLFLGHLGRSELAVGSLCTTIFNLLWFGVAGFGTGFDTLGSQAQGAADFAAV 91
Cdd:PRK00187 6 TTELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVSIFCVGVIAAVGTLVAIRHGAGDIEGA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 92 RQWAFLAAAFLTACCVPAAIVLSCGESIARtILSQDEYTSERVGRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKPVAWTS 171
Cdd:PRK00187 86 TRLAQAGLWLAWLLALVAALLLWNLKPLLL-LFGQAPQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMVIS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 172 FATFLLNIALNVLFIRIM----NLGLNGSALATTTSRVVNLILVAAYLRFSDQWSAGALTE-VWRTTTPCMcKRMFELGS 246
Cdd:PRK00187 165 LAGAVANLLLNYALIEGWfglpKLGLMGIGLVTALVSNGMALALALYIRRHPAYAAYPLRKgLSRPSRAAL-RELWRLGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 247 RGAVMVAAEASSFDVTVVFASQISQVAMNAHMAMLNITGLTFMTgPMAFGIAANVRVGNLLGAGSGFRAKVASRVSVALG 326
Cdd:PRK00187 244 PIGGTYAVEVGLFTFAALCMGALGSTQLAAHQIALQIVSVAFMV-PVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIGFG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 327 VTWMACMAALILIFRRQTGEVFV--GDKDN-EMVMLAAKIAPIAAVFQVFDGLLGTSNGVLRAC--GRQALLawMNIIAL 401
Cdd:PRK00187 323 AVVMLLFAGLFWLLPEAIIGLFLdrNDPAFaEIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLkdARTTFL--IGLACY 400
|
410 420 430
....*....|....*....|....*....|....*....
gi 226517442 402 WLVGVLSGYVITFLLKAGVIGLWYGLALGVTVGGVVLFL 440
Cdd:PRK00187 401 WLVGAPLAWLLAFTLGWGAVGVWWGLALGLACAAVALTL 439
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
23-447 |
7.22e-27 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 112.55 E-value: 7.22e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 23 LPIVVQMGSQQFMVATDLLFLGH-LGRSELAVGSLCTTIFNLLWFGVAGFGTGFDTLGSQAQGAADFAAVRQwafLAAAF 101
Cdd:cd13138 10 LPLLLSNLLQQLYNLVDLLIVGQfLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKK---AVGTL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 102 LTACCVPAAIVLSCGESIARTILSQDEYTSERVG------RFCTLLIVGLFAAAwtlVMQKFLQVRGVVKPVAWTSFATF 175
Cdd:cd13138 87 LVLFLILGIVLTILGLLFAPPILRLMNTPAEILElavsylRICFLGIPFIFGYN---AYSAILRGLGDSKTPLYFVIIAC 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 176 LLNIALNVLFIRIMNLGLNGSALATTTSRVVNLILVAAYLRFSD----------QWSAGALTEVWRTTTPCMCKRMFElg 245
Cdd:cd13138 164 VLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKlpfklslkdfRFDKEILKEILKIGLPSALQQSLV-- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 246 SRGAVMVAAEASSFDVTVVFASQISQvamnahmamlNITGLTFMTgPMAFGIAANVRVGNLLGAGSGFRAKVASRVSVAL 325
Cdd:cd13138 242 SISFLIINSIVNSYGVVASAAYGIAN----------KINSFAFLP-PSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIII 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 326 GVTWMACMAALILIFRRQTGEVFVGDKdnEMVMLAAKIAPIAAVFQVFDGLLGTSNGVLRACGRQALLAWMNIIALWLVG 405
Cdd:cd13138 311 SLIIGLIIILLVFFFAPQLLGLFTSDP--EVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVR 388
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 226517442 406 VLSGYVITFLLKAGVIGLWYGLALGVTVGGVVLFLIVTRLDW 447
Cdd:cd13138 389 IPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRW 430
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
17-442 |
4.99e-18 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 86.41 E-value: 4.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 17 ALWALVLPIVVQMGSQQFMVATDLLFLGHL-GRSELAVGSLCTTIFNLLwFGVA-GFGTGFDTLGSQAQGAADFAAVRQW 94
Cdd:cd13143 5 LFLKFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMLL-MALGlMIGVGGASLISRRLGAGDREKANRI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 95 AFLAAAFLTACC-VPAAIVLSCGESIARTILSQDEYTSERVgRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKPVAWTSFA 173
Cdd:cd13143 84 FSTALLLSLILGlLLTILGLLFLDPLLRLLGASGELLPYAV-DYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 174 TFLLNIALNVLFIRIMNLGLNGSALATTTSRVVNLILVAAYLRFsdqwSAGALTEVWRTTTPC--MCKRMFELGSRGAVM 251
Cdd:cd13143 163 GAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFR----GKSLLKLSLLRFKLSlkIIKEILALGFPSFLM 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 252 VAAEASSFDVTVVFASQISQVAMNAHMAMLN-ITGLTFMTGpMAFGIAANVRVGNLLGAGSGFRAKVASRVSVALGVTWM 330
Cdd:cd13143 239 QLSSSVVTIVLNLTLLGYGGDIGVAAFGIVTrILTFLFLPL-IGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 331 ACMAALILIFRRQTGEVFVGDKdnEMVMLAAKIAPIAAVFQVFDGLLGTSNGVLRACGRQALLAWMNIIALWLVGVLSGY 410
Cdd:cd13143 318 LVLFLILLLFPEQIVSLFTDDP--ELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPLLL 395
|
410 420 430
....*....|....*....|....*....|..
gi 226517442 411 VITFLLkaGVIGLWYGLALGVTVGGVVLFLIV 442
Cdd:cd13143 396 ILPRLF--GLDGIWLAFPLAEILTLLLALILL 425
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
20-440 |
7.09e-17 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 82.73 E-value: 7.09e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 20 ALVLPIVVQMGSQQFMVATDLLFLGHLGRSELAVGSLCTTIFNLLWFGVAGFGTGFDTLGSQAQGAADFAAVRQWAFLAA 99
Cdd:cd13135 5 HIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYAISSI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 100 AFLTACCVPAAIVLSCGESIARTILSQDEYTSERVGRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKPVAWTSFATFLLNI 179
Cdd:cd13135 85 VYNSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNLLNV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 180 ALNVLFI----RIMNLGLNGSALATTTSRVVNLILVAAYLRFSDQWSAGALTEVWRTTTPCMCKRMFELGSRGAVMVAAE 255
Cdd:cd13135 165 ILDYVLIfgnfGFPRLGIIGAAIATTIANVLNLIILVYLCRKIKKLTFKLSNTKVLKANIRPYKFTIKLGLPLGGEEFLW 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 256 ASSFDVTVVFASQISQVAMNAHMAMLNITGLTFMtgPM-AFGIAANVRVGNLLGAGSGFRAKVASRVSVALGVTWMACMA 334
Cdd:cd13135 245 NIGNLAVIRILNRIGELALGIYTLVFGIENIVLM--PMyGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYIAAA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 335 ALILIFRRQTGEVFVGDKdnEMVMLAAKIAPIAAVFQVFDGLLGTSNGVLRACGRQallAWM----NIIALWLVGVLsgY 410
Cdd:cd13135 323 IVFLAFPYKILSLFTNDP--ELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDT---KWMlytqIIGTIIVVSVA--L 395
|
410 420 430
....*....|....*....|....*....|
gi 226517442 411 VITFLLKAGVIGLWYGLALGVTVGGVVLFL 440
Cdd:cd13135 396 LLIFVFKLGLAGVYITLFIDEIIRAIINFL 425
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
249-411 |
1.62e-15 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 74.14 E-value: 1.62e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 249 AVMVAAEASSFDVTVVFASQISQVAMNAHMAMLNITGLTFMtGPMAFGIAANVRVGNLLGAGSGFRAKVASRVSVALGVT 328
Cdd:pfam01554 3 ALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFM-FLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 329 WMACMAALILIFRRQTGEVFVGDKdnEMVMLAAKIAPIAAVFQVFDGLLGTSNGVLRACGRQALLAWMNIIALwLVGVLS 408
Cdd:pfam01554 82 LSLPIALLVLLFSEPILSLFGQDE--EVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISL-LLNIPL 158
|
...
gi 226517442 409 GYV 411
Cdd:pfam01554 159 NYL 161
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
18-444 |
5.19e-15 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 76.83 E-value: 5.19e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 18 LWALVLPIVVQMGSQQFMVATDLLFLGHLGRS-ELAVGSLCTTIFNLLW--FGVAGFGTGFDTlgSQAQGAADFAAVRQW 94
Cdd:cd13136 5 ILALALPAILSNITVPLLGLVDTAVVGHLGSAaYLGAVALGTTIFNTLFwlFGFLRMGTTGLV--AQALGAGDREEAIAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 95 AFLAAAFLTACCVPAAIVLSCGESIARTILSQDEYTSERVGRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKPVAWTSFAT 174
Cdd:cd13136 83 LVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQIVG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 175 FLLNIALNVLFIRIMNLGLNGSALATTTSRVVNLILVAAYLRfsDQWSAGALTEVWRTTTPCMCKRMFELGSRGAVMVAA 254
Cdd:cd13136 163 NVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLR--RRVRLLGKSLSRRLPSKAALKRLFKLNRDIFIRTLA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 255 EASSFDVTVVFASQISQVAMNAHMAMLNITgLTFMTGPMAFGIAANVRVGNLLGAGSGFRAKVASRVSVALGVTWMACMA 334
Cdd:cd13136 241 LLAAFLFFTALAARLGDVILAANQILLQFW-LLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 335 ALILIFRRQTGEVFVGDKD-----NEMVMLAAKIAPIAAVFQVFDG-LLGTSngvlracgrqallaWMNIIALWLVGVLS 408
Cdd:cd13136 320 LLFFLGGEPIIRLFTDDPAvlalaATYLPWLALLPPIGALAFVLDGiFIGAT--------------DTRYLRNSMLVSLA 385
|
410 420 430
....*....|....*....|....*....|....*....
gi 226517442 409 GYVITFLL---KAGVIGLWYGLALGVTVGGVVLFLIVTR 444
Cdd:cd13136 386 VFLPLLFLlvpLWGNHGLWLALILFMLLRGLTLALRLPR 424
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
24-184 |
1.99e-14 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 71.06 E-value: 1.99e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 24 PIVVQMGSQQFMVATDLLFLGHLGRSELAVGSLCTTIFNLLWFGVAGFGTGFDTLGSQAQGAADFAAVRQWAFLAAAFLT 103
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 104 ACCVP-AAIVLSCGESIARtILSQDEYTSERVGRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKPVAWTSFATFLLNIALN 182
Cdd:pfam01554 81 LLSLPiALLVLLFSEPILS-LFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 226517442 183 VL 184
Cdd:pfam01554 160 YL 161
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-444 |
2.01e-11 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 65.79 E-value: 2.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 8 GSIWRsealALWALVLPIVVQMGSQQFMVATDLLFLGHLGRSELAVGSLCTTIFNLLWFGVAGFGTGFDTLGSQAQGAAD 87
Cdd:cd13149 5 GSIPR----HLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 88 FAAVRQWAFLAAAFLTACCVPAAIVLSCGESIARTILSQDEYTSERVGRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKPV 167
Cdd:cd13149 81 RNKAKRLATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 168 AWTSFATFLLNIALNVLFI----RIMNLGLNGSALATTTSRVVNLILVAAYLRFSDQ---WSAGALTEVWRTttpcmCKR 240
Cdd:cd13149 161 SLVMLGAALVNVILDPILIfgfgPIPGMGIAGAAIATVISRALGLGAALYFLHYHHRlidFSEPSLKALFRS-----WKD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 241 MFELGSRGA-VMVAAEASSFDVTVVFASQ-ISQVAmnAHMAMLNITGLTFMTgPMAFGIAANVRVGNLLGAGSGFRAKVA 318
Cdd:cd13149 236 ILSIGIPAAlSNILTPLSAAFITALVATYgPAAVA--AFGVATRIESFAFII-VMALSSALGPFVGQNWGAGQYERVQEG 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 319 SRVSVALGVTWMACMAALILIFRRQTGEVFvgDKDNEMVMLAAKIAPIAAVFQVFDGLLGTSNGVLRACGRQALLAWMNI 398
Cdd:cd13149 313 LKISLKFSLIYGAILGIVLALFAGWLASLF--SAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNL 390
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 226517442 399 IALWLVGVLSGYVITFLLkaGVIGLWYGLALGVTVGGVVLFLIVTR 444
Cdd:cd13149 391 IRVFLLYIPLAYVGSHLL--GFAGVFIGALAGNLIAGILAYFIAKK 434
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
18-444 |
5.61e-11 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 64.54 E-value: 5.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 18 LWALVLPIVVQMGSQQFMVATDLLFLGHLGRSELAVGSLCTTIFNLLWFGVAGFGTGFDTLGSQAQGAADFAAVRQWAFL 97
Cdd:cd13145 11 IRKLAIPASVGFFFNTMFNVVDTFFAGKISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 98 AAAFLTAC-CVPAAIVLSCGESIARTILSQDEYTSERVGRFCTLLIvGLFAAAWTLVMQKFLQVRGVVKPVAWTSFATFL 176
Cdd:cd13145 91 GLSFGIILaILLTVIGLFAAPPLFRLLGAEGDYLDLALEYMDVIFA-GSIFFLLNFGLNGILNAQGDTKSYRNFLIIGFF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 177 LNIALNVLFI----RIMNLGLNGSALATTTSRVVNLILVAAYLRFSDQWSagalTEVWRTTTPCM--CKRMFELGSRGAV 250
Cdd:cd13145 170 LNIILDPLFIfgggGIPAMGVSGIALATIISQFIGMFYLLYKVRKSGIIS----GCRLRDFIPRLdvYKEILKQGFPASL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 251 MVAAEASSFDVTVVFASQISQVAMNAHMAMLNITGLTFMtgP-MAFGIAANVRVGNLLGAGSGFRAKVASRVSVALGVTW 329
Cdd:cd13145 246 NMMTIGLGIFVITYFVGQFGDEAVAAYGIALRIEQILLL--PtIGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVI 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 330 MACMAALILIFRRQTGEVFvgDKDNEMVMLAAKIAPIAAVFQVFDGLLGTSNGVLRACGRQALLAWMNIIALWLVGVLSG 409
Cdd:cd13145 324 MVVATVFLLFFAEPLMSLF--TNDPAVIAIGAGYLRIDALIFYAYVVLFISVSVLQGLKRPIFALWIGLYRQLVGPALVF 401
|
410 420 430
....*....|....*....|....*....|....*
gi 226517442 410 YVITFLLKAGVIGLWYGLALGVTVGGVVLFLIVTR 444
Cdd:cd13145 402 WLLVNVLGLGVTGIWWGIFTIVWSAAIIALLYTRR 436
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-447 |
1.11e-10 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 63.70 E-value: 1.11e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 8 GSIWRSealaLWALVLPIvvqMGSQQFMVA---TDLLFLGHLGRSelAVGSLCTTIFnLLWFGVAGF---GTGFDTLGSQ 81
Cdd:cd13140 1 GPILKT----LLRLALPI---MGTSFIQMAynlTDMFWVGRLGSD--AVAAVGTAGF-FVWLAYALAllsKIGAQVKVSQ 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 82 AQGAADFAAVRQWAFLAAAFLTACCVPAAIVLS-CGESIARTILSQDEYTSERVGRFCTLLIVGLFAAAWTLVMQKFLQV 160
Cdd:cd13140 71 SIGAKDEKEARKYARNALQLNLLLGILYGLLLLlFAKPLIGFFNLGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 161 RGVVKPVAWTSFATFLLNIALNVLFIRIMN----LGLNGSALATTTSRVVNLILVAAYLRFSDQWsagaLTEVWRTTTPC 236
Cdd:cd13140 151 LGDSKTPFIINAIGLVLNIILDPLLIFGFGpfpaLGVAGAALATVLAQAIVFLLFLYALKKKKGL----FLKIRILKRPD 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 237 --MCKRMFELGSRGAVMVAAEASsfdVTVVFASQISQVAMNAHMAM---LNITGLTFMTGPmAFGIAANVRVGNLLGAGS 311
Cdd:cd13140 227 rkYIKEILKLGLPVALQSILFAL---ISMILARIIASFGPVAIAAQkvgSQIESISWMTAE-GFSTALAAFVGQNYGAGK 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 312 GFRAKVASRVSVALGVTWMACMAALILIFRRQTGEVFVgdKDNEMVMLAAKIAPIAAVFQVFDGLLGTSNGVLRACGRQA 391
Cdd:cd13140 303 YDRIRKGYKTALKIASAIGLFATLLLFFFGEPLFSLFI--PDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTK 380
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 226517442 392 LLAWMNIIALWLVGVLSGYVITFLLkaGVIGLWYGLALGVTVGGVVLFLIVTRLDW 447
Cdd:cd13140 381 PPAIISIVFNGLRIPLALLLSPTGL--GLNGIWWAISISSILKGIILTIWFLLYKK 434
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
23-221 |
1.97e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 56.56 E-value: 1.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 23 LPIVVQMGSQQFMVATDLLFLGHLGRSELAVGSLCTTIFNLLWFGVAGFGTGFDTLGSQAQGAADFAAVRqwaFLAAAFL 102
Cdd:cd13141 18 LPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEAN---AVFNQSL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 103 TACCVPAAIVLSCGESIART---ILSQDEYTSERVGRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKPVAWTSFATFLLNI 179
Cdd:cd13141 95 LLAAVLGLVVLVLGYLFGRLyleTLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQILAVLLNI 174
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 226517442 180 ALNVLFI----RIMNLGLNGSALATTTSRVVNLILVAAYLRFSDQW 221
Cdd:cd13141 175 ILAPILItgwgTGRALGVAGAGLASSISVAIAVVLLLYYFLRLEKY 220
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
141-442 |
9.09e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 51.39 E-value: 9.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 141 LIVGLFAAAWTLVMQKFLQVRGVVKPVAWTSFATFLLNIALNVLFIRIMNLGLNGSALATTTSRVVNLILVAAYLRFSdq 220
Cdd:cd13147 133 IFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSILNIILDPIFIYTLGLGIAGAAWATVISMLISSLVLLYWFFVK-- 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 221 wsagaltevwRTTTPCMCKRMFELGSRgavmVAAEASSfdvtVVFASQISQVAMNAHMAMLN----ITGLTF-------- 288
Cdd:cd13147 211 ----------KDTYVSLSLKNFKFDKK----IVKDILK----VGIPASLEQLIMSVLMIILNlilvIVAGTDgvavytag 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 289 -------MTGPMAFGIAANVRVGNLLGAGSGFRAKVASRVSVALGVTWMACMAALILIFRRQTGEVFVGDKDnemvmlAA 361
Cdd:cd13147 273 wrivsfaIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIELIIAILIFIFAPQIAYLFTYSEE------SA 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 362 KIAP-------IAAVFQVFDGLLGTSNGVLRACGRQALLAWMNIIALWLVGVLSGYVITFLLKAGVIGLWYGLALGVTVG 434
Cdd:cd13147 347 HLAPeivaflrIMCLFLPFVPFGMMSSSMFQGIGKGLTSLIITILRELIFQVLFAYLFAIVLGLGLFGVWWGIVLGNAIG 426
|
....*...
gi 226517442 435 GVVLFLIV 442
Cdd:cd13147 427 SIVGYLWA 434
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
18-445 |
1.05e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 51.08 E-value: 1.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 18 LWALVLPIVVQMGSQQFMVATDLLFLGHLGRSELAVGSLCTTIFNLLWFGVAGFGTGFDTLGSQAQGAADFAAVRQWAFL 97
Cdd:cd13144 10 LLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEANKAANN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 98 AAAFLTACCVPAAIVLSCGESIARTILSQDEYTSERVGRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKpvawTSFATFLL 177
Cdd:cd13144 90 GLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTI----TPMIAQLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 178 ----NIALNVLFI----RIMNLGLNGSALATTTSRVVNLILVAAYLRFSDQWSAGALTEvwRTTTPCMCKRMFELGSRGA 249
Cdd:cd13144 166 gaiiNIILDPILIfglfGFPAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDLRL--FRPSLRIIKEIYAVGLPSI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 250 VMVAAeaSSFDVTVV--FASQISQVAMNAHMAMLNITGLTFMTgpmAFGIAANVR--VGNLLGAGSGFRAKVASRVSVAL 325
Cdd:cd13144 244 IMQAI--SSVMVFGLnkILAGFGPTAVAVFGIYFKLQSFVFMP---VFGLNNGLIpiVAYNYGAGNKDRIREAIKYAILI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 326 GVTWMACMAALILIFRRQTGEVFvgDKDNEMVMLAAKIAPIAAVFQVFDGLLGTSNGVLRACGRQALLAWMNIIALWLVG 405
Cdd:cd13144 319 AVVIMLAGGLLFQLFPDQLLGLF--NASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVL 396
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 226517442 406 VLSGYVITFLLkaGVIGLWYGLALGVTVGGVVLFLIVTRL 445
Cdd:cd13144 397 LPLAWLLAKMF--GLNGVWWSFPIAEIVSFLLSLLFLKRL 434
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
17-212 |
1.17e-05 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 47.64 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 17 ALWALVLPIVVQMGSQQFMVATDLLFLGH-LGRSELAVGSLCTTIFNLLWFGVAGFGTGFDTLGSQAQGAADFAAVRQWA 95
Cdd:COG2244 174 LVLKYSLPLLLSGLLGLLLTNLDRLLLGAlLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLY 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 96 FLAAAFLTACCVPAAIVLSCGESIARTILSQDEYTSerVGRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKPVAWTSFATF 175
Cdd:COG2244 254 RKALRLLLLLGLPLALGLALLAPPLLSLLFGPEYAE--AAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGA 331
|
170 180 190
....*....|....*....|....*....|....*..
gi 226517442 176 LLNIALNVLFIRIMnlGLNGSALATTTSRVVNLILVA 212
Cdd:COG2244 332 VLNLVLNLLLIPRY--GLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
21-430 |
1.42e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 47.40 E-value: 1.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 21 LVLPIVVQMGSQQFMVATDLLFLGHLGRSELAVGSLCTTIFNL-LWFGVAGFG--TGFDTLGSQAQGAADFAAVRQWAFL 97
Cdd:cd13146 13 LALPILIGQLFQLLYNITDTIWISMIDPSDPALVGGIGLVFPLgMIFLALGNGiqVGVSSLLARAIGAQRAKELDQAADS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 98 -AAAFLTACCVPAAIVLSCGESIARTILSQDEYTsERVGRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKPVAWTSFATFL 176
Cdd:cd13146 93 gLALALLAATVIVVLGYIFAEPLLQLLGAKGLLL-EYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 177 LNIALNVLFIRIMNLGLNGSALATTTSRVVNLILVAayLRFSDQWSAGALTEVWRTTTPCMCKRMFELGSRGAVMVAAEA 256
Cdd:cd13146 172 VNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLL--YVFLIGKSNVTIHIKLSNISSSVIVEILRVGLPQMLLQLISS 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 257 SSFDVTVVFASQISQVAMNAHMAMLNITGLTFMTGpMAFGIAANVRVGNLLGAGSGFRAKVASRVSVALGVTWMACMAAL 336
Cdd:cd13146 250 ISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPI-FAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVLG 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 337 ILIFRRQTGEVFVGDKD-NEMVMLAAKIAPIAAVFQVFdGLLGTSngVLRACGRQALLAWMNIIALWLVGVLSGYVITFL 415
Cdd:cd13146 329 YVLVAPWLFSLFTTVPEvVAYAVLQVRTMALALPFVAI-SILVTE--FFQAIGKAWPSLLLTLIRHVFLSVPVVYLLAYV 405
|
410
....*....|....*
gi 226517442 416 LKAGVIGLWYGLALG 430
Cdd:cd13146 406 FGKGITGVYFGIVSA 420
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
177-447 |
6.94e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 45.30 E-value: 6.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 177 LNIALNVLFI----RIMNLGLNGSALATTTSRVVNLILVAAYL---RFSDQWSAGALTEVWRTTtpcmcKRMFELGSRGA 249
Cdd:cd13139 175 LNIILDPLFIfglgPIPAMGVTGAAIATTIGRSIGVLYQLYHLfkgKGRIQIRRRHLKLDWAII-----KKIIKIAVGGI 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 250 VMVAAEASSFDVTVVFASQISQVAMNAHMAMLNITGLTFMTgpmAFGI--AANVRVGNLLGAGSGFRAKVASRVSVALGV 327
Cdd:cd13139 250 LQFLIASSSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLP---AWGLsnAAATLVGQNLGAGQPDRAEKSVWRAGKYNM 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 328 TWMACMAALILIFRRQTGEVFVgdKDNEMVMLAAKIAPIAAVFQVFDGLLGTSNGVLRACGRQALLAWMNIIALWLVGVL 407
Cdd:cd13139 327 VFLGIVSLVFFLFAEPLVSFFT--TDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIP 404
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 226517442 408 SGYVITFLLKAGVIGLWYGLALGVTVGGVVLFLIVTRLDW 447
Cdd:cd13139 405 LAYLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKW 444
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
107-216 |
6.94e-05 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 45.14 E-value: 6.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 107 VPAAIVLSC-GESIARTILSQDEYTSERVGRFCTLLI---VGLFAAAWTLVMQKFLQVRGVVKPVAWTSFATFLLNIALN 182
Cdd:cd13123 307 LPAAVGLIVlAEPIVRLLFERGAFTAEDTLMTASALAayaLGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLN 386
|
90 100 110
....*....|....*....|....*....|....
gi 226517442 183 VLFIRIMnlGLNGSALATTTSRVVNLILVAAYLR 216
Cdd:cd13123 387 LLLIKPL--GHVGLALATSLSAWVNALLLLVLLR 418
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
107-216 |
3.86e-04 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 42.83 E-value: 3.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 107 VPAAIVL-SCGESIARTILSQDEYTSERVGRFCTLLI---VGLFAAAWTLVMQKFLQVRGVVKPVAWTSFATFLLNIALN 182
Cdd:COG0728 314 LPAAVGLiVLAEPIVRLLFERGAFTAEDTALTALALAayaLGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLN 393
|
90 100 110
....*....|....*....|....*....|....
gi 226517442 183 VLFIRIMnlGLNGSALATTTSRVVNLILVAAYLR 216
Cdd:COG0728 394 LLLVPPL--GHAGLALATSLSALVNALLLLVLLR 425
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
140-216 |
7.98e-04 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 41.76 E-value: 7.98e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226517442 140 LLIVGLFAAAWTLVMQKFLQVRGVVKPVAWTSFATFLLNIALNVLFIRIMnlGLNGSALATTTSRVVNLILVAAYLR 216
Cdd:cd13128 328 ILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIGALLNVILNLLLIPKY--GIIGAAIATLISEFIIFILLLYLLK 402
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
140-216 |
2.24e-03 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 38.32 E-value: 2.24e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226517442 140 LLIVGLFAAAWTLVMQKFLQVRGVVKPVAWTSFATFLLNIALNVLFirIMNLGLNGSALATTTSRVVNLILVAAYLR 216
Cdd:pfam14667 4 ILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLL--IPLFGIVGAAIATVISLLVVALLNLYYLR 78
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
106-216 |
2.60e-03 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 40.14 E-value: 2.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 106 CVPAAIVLSC-GESIARTIlsqdeYTSERVGRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKPVAWTSFATFLLNIALNVL 184
Cdd:cd13124 325 GLPAAVGLAVlAEPINTLL-----FGDSEGGLILQILAPSILFLSLQQVTAAILQGLGKVKIPVINLLIGLLVKIVLNYV 399
|
90 100 110
....*....|....*....|....*....|..
gi 226517442 185 FIRImnLGLNGSALATTTSRVVNLILVAAYLR 216
Cdd:cd13124 400 LIPI--FGIYGAAIATVIGFLVAALLNLRALK 429
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
172-253 |
2.96e-03 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 39.98 E-value: 2.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 172 FATFL------LNIALNVLFIRIMNLGLNGSALATTTSRVVNLILVAAYL--RFSD-QWSAGALTEVWRtttpcMCKRMF 242
Cdd:PRK09575 163 LATGLmvigalINIVLDYLFIGWLDWGLTGAAIATALAQLVVTVLGLGYFfsSRANiRLTLKELRFNWS-----LAPKIV 237
|
90
....*....|.
gi 226517442 243 ELGSRGAVMVA 253
Cdd:PRK09575 238 LLGSSSFFMYL 248
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
23-216 |
3.75e-03 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 39.61 E-value: 3.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 23 LPIVVQMGSQQFMVATDLLFLGHL-GRSELAVGSLCTTIFNLLWFGVAGFGTGFDTLGSQAQGAADFAAVRQ-WAFLAAA 100
Cdd:cd12082 226 LPSAIQNSLLSLGLLIIVAIVAAFgGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRiTWVALLI 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226517442 101 FLTACCVPAAIVLSCGESIARtILSQDEYTSERVGRFCTLLIVGLFAAAWTLVMQKFLQVRGVVKPVAWTSFATFLLNIA 180
Cdd:cd12082 306 GLLIGAVLGLLILLFPEPILS-LFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRL 384
|
170 180 190
....*....|....*....|....*....|....*.
gi 226517442 181 LNVLFIRIMNLGLNGSALATTTSRVVNLILVAAYLR 216
Cdd:cd12082 385 PLAYVLAYLGLGLYGIWLALVISLILAALVLLLFFR 420
|
|
| |
