|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
12-458 |
9.26e-161 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 462.05 E-value: 9.26e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 12 RERILYGSIGRTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQVMPTFMLWNSIAQGLMAANLALITQLLGA 91
Cdd:cd13142 1 RENILEGSILRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 92 RRYDEARKYVSFFVSATLLINSVVSIIYFILRPMIFSYIVRTPPLLYNDTLTYSGIITLDIVFSAFTLTYSTILQSIGDT 171
Cdd:cd13142 81 GDYDKANKVAGQTFSFVIILSLILAVLGYILSRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 172 RTPALINFGAASMNMVLDPIFILGVGIngsmlIPPMGVAGAAYATILSRFIGLLLLYDRLNKKYPYLKPRL-TLKIESDW 250
Cdd:cd13142 161 KTPMKIMFGSVLLNVILDPLLIFGIGP-----FPGLGVAGAALATVISRGIAAVIGLYLLFKGRVGLKISLrDLKPDWEW 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 251 LAKNLRIGAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKV 330
Cdd:cd13142 236 LKKIFRIGLPSSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEI 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 331 AFKSMLYIGVSTLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGIIR 410
Cdd:cd13142 316 VKKAALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILR 395
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 218765129 411 LWGIRILLGYILAFTIGLGSLGVWISMSLSNVVAGLLMIIWVARGGWA 458
Cdd:cd13142 396 LWVIRIPLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTWK 443
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
15-451 |
2.04e-84 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 266.24 E-value: 2.04e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 15 ILYGSIGRTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQVMPTFMLWNSIAQGLMAANLALITQLLGARRY 94
Cdd:COG0534 1 LTEGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 95 DEARKYVSFFVSATLLINSVVSIIYFILRPMIFSYIvRTPPLLYNDTLTYSGIITLDIVFSAFTLTYSTILQSIGDTRTP 174
Cdd:COG0534 81 EEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLL-GADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 175 ALINFGAASMNMVLDPIFILGvgingsmliPPMGVAGAAYATILSRFIGLLLLYDRLNKKYPYLKPRL-TLKIESDWLAK 253
Cdd:COG0534 160 MIIMLIGNVLNIVLDPLLIFG---------GGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLrDLRPDRKILKR 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 254 NLRIGAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAFK 333
Cdd:COG0534 231 ILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 334 SMLYIGVSTLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGIIRLWG 413
Cdd:COG0534 311 ALLLALGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWL 390
|
410 420 430
....*....|....*....|....*....|....*...
gi 218765129 414 IRILLGYILAFTiGLGSLGVWISMSLSNVVAGLLMIIW 451
Cdd:COG0534 391 VRLPLAYLLAFL-GLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
20-457 |
1.94e-81 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 258.54 E-value: 1.94e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 20 IGRTLLWLGLPLMVVQLVNVSYNIVDTYWLSRY-SEIAYAVPRQVMPTFMLWNSIAQGLMAANLALITQLLGARRYDEAR 98
Cdd:cd13138 1 ILKTLLLFALPLLLSNLLQQLYNLVDLLIVGQFlGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 99 KYVSFFVSATLLINSVVSIIYFILRPMIFSyIVRTPPLLYNDTLTYSGIITLDIVFSAFTLTYSTILQSIGDTRTPALIN 178
Cdd:cd13138 81 KAVGTLLVLFLILGIVLTILGLLFAPPILR-LMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 179 FGAASMNMVLDPIFILGVGingsmlippMGVAGAAYATILSRFIGLLLLYDRLNKKYPYLKPRL-TLKIESDWLAKNLRI 257
Cdd:cd13138 160 IIACVLNIILDLLFIAVFH---------MGVAGAALATVIAQAISVLLALYYLRKKKLPFKLSLkDFRFDKEILKEILKI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 258 GAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAFKSMLY 337
Cdd:cd13138 231 GLPSALQQSLVSISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIII 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 338 IGVSTLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGIIRLWGIRIL 417
Cdd:cd13138 311 SLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIP 390
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 218765129 418 LGYILAFTIGLGSLGVWISMSLSNVVAGLLMIIWVARGGW 457
Cdd:cd13138 391 LAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRW 430
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
22-458 |
6.52e-72 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 233.94 E-value: 6.52e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 22 RTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQVMPTFMLWNSIAQGLMAANLALITQLLGARRYDEARKYV 101
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 102 SFFVSATLLINSVVSIIYFILRPMIFSyIVRTPPLLYNDTLTYSGIITLDIVFSAFTLTYSTILQSIGDTRTPALINFGA 181
Cdd:cd13137 81 GQSLLLALLLSLPLALLGLLFAEPLLR-LLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 182 ASMNMVLDPIFILGVGIngsmlIPPMGVAGAAYATILSRFIG-LLLLYDRLNKKYPYLKPRLTLKIESDWLAKNLRIGAP 260
Cdd:cd13137 160 NVLNIVLDYVLIFGLWG-----FPGLGVAGAALATVISRVVGaLLLLFLLLRGRLPIKISFKGFRLDRKIIKKLLRIGLP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 261 VTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAFKSMLYIGV 340
Cdd:cd13137 235 AGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 341 STLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGIIRLWGIRILLGY 420
Cdd:cd13137 315 FMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAY 394
|
410 420 430
....*....|....*....|....*....|....*...
gi 218765129 421 ILAFTIGLGSLGVWISMSLSNVVAGLLMIIWVARGGWA 458
Cdd:cd13137 395 LLGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKWK 432
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
22-457 |
6.44e-57 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 194.64 E-value: 6.44e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 22 RTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQVMPTFMLWNSIAQGLMAANLALITQLLGARRYDEARKYV 101
Cdd:cd13134 3 LSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 102 SFFVSATLLINSVVSIIYFILRPMIFSyIVRTPPLLYNDTLTYSGIITLDIVFSAFTLTYSTILQSIGDTRTPALINFGA 181
Cdd:cd13134 83 GVALLFNLLLGLVFSLLLLFFGAELLR-LMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 182 ASMNMVLDPIFILGVGIngsmlIPPMGVAGAAYATILSRFIGLLLLYDRLNKKY-PYLKPRLTLKIESDWLAKNLRIGAP 260
Cdd:cd13134 162 NILNIVGNYLLIFGWFG-----LPKLGVAGVAISTVISRAVGLVLLFILLFRKLkIRFRLKDLRPFPKKLLKKILKIGLP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 261 VTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAFKSMLYIGV 340
Cdd:cd13134 237 SAGEELSYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 341 STLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGIIRLWGIRILLGY 420
Cdd:cd13134 317 VSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLAY 396
|
410 420 430
....*....|....*....|....*....|....*..
gi 218765129 421 ILAFTIGLGSLGVWISMSLSNVVAGLLMIIWVARGGW 457
Cdd:cd13134 397 LLGIVLGLGLLGVWIAFAADEWVRGIIMLWRWRSGKW 433
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
18-451 |
6.40e-55 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 189.27 E-value: 6.40e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 18 GSIGRTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQVMptFMLWNSIAQGLMAANLA--LITQLLGARRYD 95
Cdd:cd13140 1 GPILKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVGTAG--FFVWLAYALALLSKIGAqvKVSQSIGAKDEK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 96 EARKYVSFFVSATLLINSVVSIIYFILRPMIFSYIVRTPPLLYNDTLTYSGIITLDIVFSAFTLTYSTILQSIGDTRTPA 175
Cdd:cd13140 79 EARKYARNALQLNLLLGILYGLLLLLFAKPLIGFFNLGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 176 LINFGAASMNMVLDPIFILGVGIngsmlIPPMGVAGAAYATILSRFIG-LLLLYDRLNKKYPYLKPRLTLKIESDWLAKN 254
Cdd:cd13140 159 IINAIGLVLNIILDPLLIFGFGP-----FPALGVAGAALATVLAQAIVfLLFLYALKKKKGLFLKIRILKRPDRKYIKEI 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 255 LRIGAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAFKS 334
Cdd:cd13140 234 LKLGLPVALQSILFALISMILARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 335 MLYIGVSTLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGIIrLWGI 414
Cdd:cd13140 314 LKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAIISIV-FNGL 392
|
410 420 430
....*....|....*....|....*....|....*..
gi 218765129 415 RILLGYILAFTiGLGSLGVWISMSLSNVVAGLLMIIW 451
Cdd:cd13140 393 RIPLALLLSPT-GLGLNGIWWAISISSILKGIILTIW 428
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
29-452 |
7.82e-51 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 177.90 E-value: 7.82e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 29 LPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQVMPTFMLWNSIAQGLMAANLALITQLLGARRYDEARKYVSFFVSAT 108
Cdd:cd12082 2 APLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 109 LLINSVVSIIYFILRPMIFSyIVRTPPLLYNDTLTYSGIITLDIVFSAFTLTYSTILQSIGDTRTPALINFGAASMNMVL 188
Cdd:cd12082 82 ILLGLLLAALLLFFSPLILS-LLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 189 DPIFILGVGIngsmliPPMGVAGAAYATILSRFIGLLLLYDRLNKKYPYLKPRLTL-KIESDWLAKNLRIGAPVTLMMAS 267
Cdd:cd12082 161 DPLLIFGLGP------PELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLlKPDLELLRRLLRIGLPSAIQNSL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 268 NSLAFMFQNALINQF-GEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAFKSMLYIGVSTLIGS 346
Cdd:cd12082 235 LSLGLLIIVAIVAAFgGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLG 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 347 SIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGIIRLWGIRILLGYILAFtI 426
Cdd:cd12082 315 LLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAY-L 393
|
410 420
....*....|....*....|....*.
gi 218765129 427 GLGSLGVWISMSLSNVVAGLLMIIWV 452
Cdd:cd12082 394 GLGLYGIWLALVISLILAALVLLLFF 419
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
18-457 |
1.89e-43 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 158.93 E-value: 1.89e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 18 GSIGRTLLWLGLPlMVVQLVNVS-YNIVDTYWLSRYSEIAYAVPRQVMPTFMLWNSIAQGLMAANLALITQLLGARRYDE 96
Cdd:cd13139 10 GSLNRAIFLLAIP-MVLEMVMESlFAVVDLYFVSRLGALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKDPEG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 97 ARKYVSFFVSATLLINSVVSIIYFILRPMIFSYIVRTPPLLYNDTLtYSGIITLDIVFSAFTLTYSTILQSIGDTRTPAL 176
Cdd:cd13139 89 AGFAAVQAILLGVALSLILSILGYFFAEDILSLMGASPAVIAEGYG-YTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMR 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 177 INFGAASMNMVLDPIFILGVGIngsmlIPPMGVAGAAYATILSRFIGLLLLYDRLNKKYPYLKPRLT-LKIESDWLAKNL 255
Cdd:cd13139 168 SLWLANGLNIILDPLFIFGLGP-----IPAMGVTGAAIATTIGRSIGVLYQLYHLFKGKGRIQIRRRhLKLDWAIIKKII 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 256 RIGAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAFKSM 335
Cdd:cd13139 243 KIAVGGILQFLIASSSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRAG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 336 LYIGVSTLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGIIRLWGIR 415
Cdd:cd13139 323 KYNMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQ 402
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 218765129 416 ILLGYILAFTIGLGSLGVWISMSLSNVVAGLLMIIWVARGGW 457
Cdd:cd13139 403 IPLAYLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKW 444
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
18-454 |
2.92e-40 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 150.06 E-value: 2.92e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 18 GSIGRTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQVMPTFMLWNSIAQGLMAANLALITQLLGARRYDEA 97
Cdd:cd13145 5 GPIPKLIRKLAIPASVGFFFNTMFNVVDTFFAGKISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 98 RKYVSFFVSATLLINSVVSIIYFILRPMIFSYIVRTPPLLyNDTLTYSGIITLDIVFSAFTLTYSTILQSIGDTRTPALI 177
Cdd:cd13145 85 RRYAAQGLSFGIILAILLTVIGLFAAPPLFRLLGAEGDYL-DLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 178 NFGAASMNMVLDPIFILGVGIngsmlIPPMGVAGAAYATILSRFIGLLLLYDRLNK-------KYPYLKPRLtlkiesDW 250
Cdd:cd13145 164 LIIGFFLNIILDPLFIFGGGG-----IPAMGVSGIALATIISQFIGMFYLLYKVRKsgiisgcRLRDFIPRL------DV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 251 LAKNLRIGAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKV 330
Cdd:cd13145 233 YKEILKQGFPASLNMMTIGLGIFVITYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRET 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 331 AFKSMLYIGVSTLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGIIR 410
Cdd:cd13145 313 YKKALKYGFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIGAGYLRIDALIFYAYVVLFISVSVLQGLKRPIFALWIGLYR 392
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 218765129 411 LWGIRILLGYILAFTIGLGSLGVWISMSLSNVVAGLLMIIWVAR 454
Cdd:cd13145 393 QLVGPALVFWLLVNVLGLGVTGIWWGIFTIVWSAAIIALLYTRR 436
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
22-457 |
6.39e-40 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 148.83 E-value: 6.39e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 22 RTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVprqVMP---TFMLWNSIAQGLMAANLALITQLLGARRYDEAR 98
Cdd:cd13133 5 REILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAA---SGPagvLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 99 KYVSFFVSATLLINSVVSIIYFILRPMIFSYIVrTPPLLYNDTLTYSGIITLDIVFSAFTLTYSTILQSIGDTRTPALIN 178
Cdd:cd13133 82 RVLWQGLYFSLLLAPLLALLSALAAPLLFLLLG-HSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVAN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 179 FGAASMNMVLDPIFILGVGIngsmlIPPMGVAGAAYATILSRFIGLL--LLYDRLNKKYPYLKPRLTLKIESDWLAKNLR 256
Cdd:cd13133 161 LVMVVVNIVLDYALIFGKLG-----FPAMGIAGAAIATVIAEAVSLLffLLLLFRRKNRRRFGLRRAWRFDRELLRRILR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 257 IGAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAFKSML 336
Cdd:cd13133 236 LGLPSGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLK 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 337 YIGVSTLIGSSIVYMLREAFISVFTDN---QVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGIIRLWG 413
Cdd:cd13133 316 LALAYMLLLGILFLLFPELLLSIFTPGadfALIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWL 395
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 218765129 414 IrILLGYILAFTIGLGSLGVWISMSLSNVVAGLLMIIWVARGGW 457
Cdd:cd13133 396 Y-LLPPAYLLVVLGAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
19-452 |
4.32e-39 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 146.50 E-value: 4.32e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 19 SIGRTLLWLGLPLMVVQLVNVSYNIVDTYWLSRY-SEIAYAVPRQVMPTFMLWNSIAQGLMAANLALITQLLGARRYDEA 97
Cdd:cd13143 1 PIGKLFLKFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 98 RKYVSFFVSATLLINSVVSIIYFILRPMIFsYIVRTPPLLYNDTLTYSGIITLDIVFSAFTLTYSTILQSIGDTRTPALI 177
Cdd:cd13143 81 NRIFSTALLLSLILGLLLTILGLLFLDPLL-RLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 178 NFGAASMNMVLDPIFILGVGingsmlippMGVAGAAYATILSRFIGLLLLYDRLNKKYPYLKP-RLTLKIESDWLAKNLR 256
Cdd:cd13143 160 MLIGAVLNIILDPLFIFVLG---------LGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLsLLRFKLSLKIIKEILA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 257 IGAPVTLMMASNSLAFMFQNALINQFGeYVAAAAAIGLIM--MDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAFKS 334
Cdd:cd13143 231 LGFPSFLMQLSSSVVTIVLNLTLLGYG-GDIGVAAFGIVTriLTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLA 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 335 MLYIGVSTLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGIIRLWGI 414
Cdd:cd13143 310 LIVALIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLF 389
|
410 420 430
....*....|....*....|....*....|....*...
gi 218765129 415 RILLGYILAFTIGLGslGVWISMSLSNVVAGLLMIIWV 452
Cdd:cd13143 390 LIPLLLILPRLFGLD--GIWLAFPLAEILTLLLALILL 425
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
17-454 |
4.89e-38 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 143.53 E-value: 4.89e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 17 YGSIGRTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQVMPTFMLWNSIAQGLMAANLALITQLLGARRYDE 96
Cdd:cd13144 3 SGPVLRLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 97 ARKYVSFFVSATLLINSVVSIIYFILRPMIFSYIVRTPPLLyNDTLTYSGIITLDIVFSAFTLTYSTILQSIGDTRTPAL 176
Cdd:cd13144 83 ANKAANNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEIL-EYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 177 INFGAASMNMVLDPIFILGVGIngsmlIPPMGVAGAAYATILSRFIGLLLLYDRLNKKYPYLKPRLTL-KIESDWLAKNL 255
Cdd:cd13144 162 AQLIGAIINIILDPILIFGLFG-----FPAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDLRLfRPSLRIIKEIY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 256 RIGAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAFKSM 335
Cdd:cd13144 237 AVGLPSIIMQAISSVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAI 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 336 LYIGVSTLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGIIRLWGIR 415
Cdd:cd13144 317 LIAVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVL 396
|
410 420 430
....*....|....*....|....*....|....*....
gi 218765129 416 ILLGYILAFTIGLGslGVWISMSLSNVVAGLLMIIWVAR 454
Cdd:cd13144 397 LPLAWLLAKMFGLN--GVWWSFPIAEIVSFLLSLLFLKR 433
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
14-454 |
5.91e-37 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 140.52 E-value: 5.91e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 14 RILYGSIGRTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQVMPTFMLWNSIAQGLMAANLALITQLLGARR 93
Cdd:cd13149 1 KLTEGSIPRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 94 YDEARKYVSFFVSATLLINSVVSIIYFILRPMIFSYIVRTPPLLyNDTLTYSGIITLDIVFSAFTLTYSTILQSIGDTRT 173
Cdd:cd13149 81 RNKAKRLATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEIL-PLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 174 PALINFGAASMNMVLDPIFILGVGIngsmlIPPMGVAGAAYATILSRFIGLLLLYDRLNKKYPYLKP-RLTLKIESDWLA 252
Cdd:cd13149 160 PSLVMLGAALVNVILDPILIFGFGP-----IPGMGIAGAAIATVISRALGLGAALYFLHYHHRLIDFsEPSLKALFRSWK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 253 KNLRIGAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAF 332
Cdd:cd13149 235 DILSIGIPAALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLK 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 333 KSMLYIGVSTLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGIIRLW 412
Cdd:cd13149 315 ISLKFSLIYGAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVF 394
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 218765129 413 GIRILLGYILAFTIGLGslGVWISMSLSNVVAGLLMIIWVAR 454
Cdd:cd13149 395 LLYIPLAYVGSHLLGFA--GVFIGALAGNLIAGILAYFIAKK 434
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
22-450 |
1.34e-35 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 136.86 E-value: 1.34e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 22 RTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVprqVMPTFMLWNSI---AQGLMAANLALITQLLGARRYDEAR 98
Cdd:cd13131 3 RALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAA---VALGSSLWFPVftfGMGLLLAVTPLVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 99 KYV-SFFVSATLLinSVVSIIYFILRPMIFSYIvRTPPLLYNDTLTYSGIITLDIVFSAFTLTYSTILQSIGDTRTPALI 177
Cdd:cd13131 80 RAVrQGLWLALLL--SLPLMLLLWLAPPILPLM-GQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 178 NFGAASMNMVLDPIFILGVGinGsmlIPPMGVAGAAYATILSRFIGLLLLYDRLNKKYPYLKPRLTLKIE-SDW--LAKN 254
Cdd:cd13131 157 TLLALVLNIPLNYVLIFGKF--G---LPALGGAGAGLATAIVYWLMFLALAFYIRRHKRFRRYRLFARFWrPDWarLKEL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 255 LRIGAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAFKS 334
Cdd:cd13131 232 LRLGLPIGLTIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVG 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 335 MLYIGVSTLIGSSIVYMLREAFISVFTDNQVILSEADRFItvflpsivFFALFF--------IGMSVGRGSGHTMVPTIM 406
Cdd:cd13131 312 LGLGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLL--------VFAALFqlfdgiqvVAAGALRGYKDTRVPFLL 383
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 218765129 407 GIIRLWGIRILLGYILAFTIGLGSLGVWISMSLSNVVAGLLMII 450
Cdd:cd13131 384 ALISYWGIGLPLGYLLAFTTGLGAFGVWIGLIIGLALAAILLLW 427
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
12-456 |
3.20e-34 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 133.17 E-value: 3.20e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 12 RERILYGSIGRTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQVMPTFMLWNSIAQGLMAANLA-LITQLLG 90
Cdd:cd13148 2 TRALLTAPILPTLLRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVALVFPLLMLTQMMSNGAMGGGVSsAIARALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 91 ARRYDEARKYVSFFVSATLLINSVVSIIYFILRPMIFSYIVRTPPLLyNDTLTYSGIITLDIVFSAFTLTYSTILQSIGD 170
Cdd:cd13148 82 AGDRERAEALVWHALVIALAGGLVFSLLFLLFGPALYRLLGGRGEAL-DAALAYSNVLFSGAILIWLVNLLAAALRGTGN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 171 TRTPALINFGAASMNMVLDPIFILGVGingsmLIPPMGVAGAAYATILSRFIGLLLLYDRLNKKYPYLKPRL-TLKIESD 249
Cdd:cd13148 161 MRVPALVTLVGAVVQIPLSPGLILGWG-----PLPRLGVAGAAVAAVLYYALAALVLLRYLASGRSRLRLRLrALRLERR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 250 WLAKNLRIGAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARK 329
Cdd:cd13148 236 LFRDILRVGLLAALSPLQTNLTVLLLTGLVGRFGTAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIGAGQIARARR 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 330 VAFKSMLYIGVSTLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGII 409
Cdd:cd13148 316 IAWTGALMAAVLAGAIGLVLALFPELWLGLFTHDPAVLAAGASYLRIVGPFYGFFGLGLALYFASQGAGRMLWPVLAGTL 395
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 218765129 410 RLwGIRILLGYILAFTIGLGSLGVWISMSLSNVVAGLLMIIWVARGG 456
Cdd:cd13148 396 RL-LIAAGGGWIAVALFGAGLAGLFAAAAAAMVAYGLVTAAAVKLGA 441
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
27-452 |
4.58e-34 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 132.67 E-value: 4.58e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 27 LGLPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQVMPTFMLWNSIAQGLMAANLALITQLLGARRYDEARKYVSFFVS 106
Cdd:cd13147 14 LSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNAAVHSIL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 107 ATLLINSVVSIIYFILRPMIFSYIVRTPPLLYndTLTYSGIITLDIVFSAFTLTYSTILQSIGDTRTPALINFGAASMNM 186
Cdd:cd13147 94 LGLIISIILTIVLLPFLEPILVLMGAGEVLDL--AVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSILNI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 187 VLDPIFILGVGingsmlippMGVAGAAYATILSRFI-GLLLLYDRLNKKYPYLKPRLT-LKIESDWLAKNLRIGAPVTLM 264
Cdd:cd13147 172 ILDPIFIYTLG---------LGIAGAAWATVISMLIsSLVLLYWFFVKKDTYVSLSLKnFKFDKKIVKDILKVGIPASLE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 265 MASNSLAFMFQNA-LINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAFKSMLYIGVSTL 343
Cdd:cd13147 243 QLIMSVLMIILNLiLVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIEL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 344 IGSSIVYMLREAFISVFTDNQVI------LSEADRFITVFLPsivFFALFFIGMSVGRGSGHTMVPTIMGIIRLWGIRIL 417
Cdd:cd13147 323 IIAILIFIFAPQIAYLFTYSEESahlapeIVAFLRIMCLFLP---FVPFGMMSSSMFQGIGKGLTSLIITILRELIFQVL 399
|
410 420 430
....*....|....*....|....*....|....*
gi 218765129 418 LGYILAFTIGLGSLGVWISMSLSNVVAGLLMIIWV 452
Cdd:cd13147 400 FAYLFAIVLGLGLFGVWWGIVLGNAIGSIVGYLWA 434
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
22-457 |
5.77e-30 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 121.14 E-value: 5.77e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 22 RTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEI---AYAVprQVMPTFMLWNSIAQGLMAANLALITQLLGARRYDEAR 98
Cdd:cd13132 3 KKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLelaAASL--ASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 99 KYV--SFFVSATLLInsVVSIIYFILRPmIFSYIvRTPPLLYNDTLTYSGIITLDIVFSAFTLTYSTILQSIGDTRTPAL 176
Cdd:cd13132 81 VYLqrALVILLLCCV--PISLLWLNTEP-ILLLL-GQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 177 INFGAASMNMVLDPIFILGVGingsmlippMGVAGAAYATILSRFI--GLLLLYDRLNKKYPYLKPRLTLKIESDWLaKN 254
Cdd:cd13132 157 ISLVALLLNILLNYLLVFVLG---------LGFIGAALATSISYWLivVLLLLYIFFSKGHKATWGGFSREAFRGWG-PF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 255 LRIGAPVTLMMASNSLAFMFQNALINQF-GEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAFK 333
Cdd:cd13132 227 LKLAIPSALMLCLEWWAFEILVLLAGLLpGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIV 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 334 SMLYIGVSTLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGIIRLWG 413
Cdd:cd13132 307 ALILSLVIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYL 386
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 218765129 414 IRILLGYILAFTIGLGSLGVWISMSLSNVVAGLLMIIWVARGGW 457
Cdd:cd13132 387 IGLPVGLLLAFVLGLGLKGLWIGLIAGLILQAVILLLIILRTDW 430
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
30-373 |
4.20e-29 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 116.96 E-value: 4.20e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 30 PLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQVMPTFMLWNSIAQGLMAANLALITQLLGARRYDEARKYVSFFVSATL 109
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 110 LINSVVSIIYFILRPMIFSYIVRTPPLLyNDTLTYSGIITLDIVFSAFTLTYSTILQSIGDTRTPALINFGAASMNMVLD 189
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSLMGADGEVA-ELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 190 PIFILGVgingsmlIPPMGVAGAAYATILSRFI--GLLLLYDRLNKKYpYLKPRLTLKIESDWLAKNLRIGAPVTLMMAS 267
Cdd:TIGR00797 160 YILIFGK-------FGFLGIVGAALATVISYWLmfLLLLYYIKKAKKI-GLKWEGLLKPDWEVLKRLLKLGLPIAFRVIL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 268 NSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAFK-SMLYIGVSTLIGs 346
Cdd:TIGR00797 232 ESLSFALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVaLKLSLLLGLVLA- 310
|
330 340
....*....|....*....|....*..
gi 218765129 347 SIVYMLREAFISVFTDNQVILSEADRF 373
Cdd:TIGR00797 311 IILILFREFIARLFTNDPEVLELAAIY 337
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
15-452 |
1.81e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 105.18 E-value: 1.81e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 15 ILYGSIGRTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQ---VMPTFMLWNSIAQGLMAANLALITQLLGA 91
Cdd:cd13146 1 MFSGPISPLLIRLALPILIGQLFQLLYNITDTIWISMIDPSDPALVGGiglVFPLGMIFLALGNGIQVGVSSLLARAIGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 92 RRYDEARKYVSFFVSATLLINSVVSIIYFILRPMIFSYIVRTpPLLYNDTLTYSGIITLDIVFSAFTLTYSTILQSIGDT 171
Cdd:cd13146 81 QRAKELDQAADSGLALALLAATVIVVLGYIFAEPLLQLLGAK-GLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 172 RTPALINFGAASMNMVLDPIFILGVGingsmlippMGVAGAAYATILSRFIGLLLLYDRLNKKYPYLKPRLTL-KIESDW 250
Cdd:cd13146 160 KYMMMAMLIGTVVNIVLDPILIFVFD---------MGVKGAALATVLAQAISLLYLLYVFLIGKSNVTIHIKLsNISSSV 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 251 LAKNLRIGAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRArKV 330
Cdd:cd13146 231 IVEILRVGLPQMLLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRM-LQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 331 AFKSMLYIGVSTLIGSSIVYMLREAFI-SVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGII 409
Cdd:cd13146 310 ILMTAVILGIVVVLVLVLGYVLVAPWLfSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLI 389
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 218765129 410 RLWGIRILLGYILAFTIGLGSLGVWISMSLSNVVAGLLMIIWV 452
Cdd:cd13146 390 RHVFLSVPVVYLLAYVFGKGITGVYFGIVSANFFTALLAMFWG 432
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
169-454 |
2.33e-19 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 89.93 E-value: 2.33e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 169 GDTRTPALINFGAASMNMVLDPIFILGVGingsmlippMGVAGAAYATILSRFIGLLLLYDRLNKKYPYLKPRLTLKIES 248
Cdd:cd13136 150 QDTRTPLILQIVGNVVNIVLDPLFVFGLG---------WGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLPS 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 249 -DWLAKNLRIGAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRA 327
Cdd:cd13136 221 kAALKRLFKLNRDIFIRTLALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAA 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 328 RKVAFKSMLYIGVSTLIGSSIVYMLREAFISVFTDNQVILSEADRFI--TVFLPSIVFFALFFIGMSVGRGSGHTMvpti 405
Cdd:cd13136 301 RRVARRLLQWGLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLpwLALLPPIGALAFVLDGIFIGATDTRYL---- 376
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 218765129 406 mgiiRLWGIRILLGYILAFTI---GLGSLGVWISMSLSNVVAGLLMIIWVAR 454
Cdd:cd13136 377 ----RNSMLVSLAVFLPLLFLlvpLWGNHGLWLALILFMLLRGLTLALRLPR 424
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
27-443 |
6.33e-19 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 88.89 E-value: 6.33e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 27 LGLPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQV-MPTFMLWNSIAQGLMAANLaLITQLLGARRYDEARKYVSffv 105
Cdd:cd13135 6 IAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVtTPFNTITGFLGSISIGFTI-LGSQSVGAKDIKRINDYAI--- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 106 sATLLINSVVSIIYFIL----RPMIFSYIVRTPPLLyNDTLTYSGIITLDIVFSAFTLTYSTILQSIGDTRTPALINFGA 181
Cdd:cd13135 82 -SSIVYNSIIGVILFLLwlfgARIIFVLFGVDGQIL-GYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 182 ASMNMVLDPIFILGvgingSMLIPPMGVAGAAYATILSRFIGLLLL--YDRLNKKYPYlKPRLTLKIESDW--LAKNLRI 257
Cdd:cd13135 160 NLLNVILDYVLIFG-----NFGFPRLGIIGAAIATTIANVLNLIILvyLCRKIKKLTF-KLSNTKVLKANIrpYKFTIKL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 258 GAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAFKSMLY 337
Cdd:cd13135 234 GLPLGGEEFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 338 IGVSTLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHT---MVPTIMGIIrlwgI 414
Cdd:cd13135 314 GLLIYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTkwmLYTQIIGTI----I 389
|
410 420
....*....|....*....|....*....
gi 218765129 415 RILLGYILAFTIGLGSLGVWISMSLSNVV 443
Cdd:cd13135 390 VVSVALLLIFVFKLGLAGVYITLFIDEII 418
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
18-411 |
7.71e-19 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 88.53 E-value: 7.71e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 18 GSIGRTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQVMPTFMLWNSIAQGLMAANLALITQLLGARRYDEA 97
Cdd:cd13141 7 GSIPKHIISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 98 RKYVSFFVSATLLINSVVSIIYFILRPMIFSYIVrtppllyNDTLTYSGIIT----------LDIVFSAFtltySTILQS 167
Cdd:cd13141 87 NAVFNQSLLLAAVLGLVVLVLGYLFGRLYLETLA-------ADAATVEAATTylywfipslaLQFILTVL----GAALRG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 168 IGDTRTPALINFGAASMNMVLDPIFILGVGIngsmlIPPMGVAGAAYATILSRFIG--LLLLYDRLNKKYPYLKPRLtLK 245
Cdd:cd13141 156 TGIVKPFMVIQILAVLLNIILAPILITGWGT-----GRALGVAGAGLASSISVAIAvvLLLYYFLRLEKYLRLDLAL-WR 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 246 IESDWLAKNLRIGAPVTLMMAsnsLAFMFQNA---LINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAG 322
Cdd:cd13141 230 PDLPTWKRLLKIGLPSGGEFL---LTFVYMAViywALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAG 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 323 LIDRARKVAFKSMLYIGVSTLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMV 402
Cdd:cd13141 307 NYDRVRETFRITAILTTALMLVLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWP 386
|
....*....
gi 218765129 403 PTIMGIIRL 411
Cdd:cd13141 387 SLLSSASRL 395
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
17-450 |
1.50e-17 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 84.86 E-value: 1.50e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 17 YGSIGRTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEI---AYAVPRQV-MPTFMlwnsIAQGLMAANLALITQLLGAR 92
Cdd:PRK01766 7 YKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATdlaAVAIGTSIwLPVIL----FGHGLLLALTPIVAQLNGAG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 93 RYDEarkyVSFFVSATLLINSVVSIIYfilrpMIFSYIVRTPPLLYNDTLTYSGIITLD----IVFSAFTLTYSTILQS- 167
Cdd:PRK01766 83 RRER----IAHQVRQGLWLALFLSVLI-----MLVLYNAVPPILNMMNLEPEVADIAVGylhaLLWGIPAYLLYQVLRSf 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 168 ---IGDTRTPALINFGAASMNMVLDPIFIlgvgiNGSMLIPPMGVAGAAYATILSRFIGLLLLYDRLNKKYPYLKPRLTL 244
Cdd:PRK01766 154 idgLGKTKPTMVIGFLGLLINIPLNYIFI-----YGKFGFPELGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDFRLFK 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 245 KIES-DW--LAKNLRIGAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGL--------IMMDLADATlwgftssiAV 313
Cdd:PRK01766 229 GLYKpDWavIKRLLKLGLPIGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIALnfssllfmLPLSLAMAL--------TI 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 314 MVGQALGAGLIDRARKVAFKSMLyIGVST-LIGSSIVYMLREAFISVFTDNQVILSEADRFItvflpsivFFALFF---- 388
Cdd:PRK01766 301 RVGFELGAGRTLDARQYAYIGLA-VGLGMaLLTAIFLVLFREQIALLYTDDPEVVALASHLL--------LFAALFqfsd 371
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 218765129 389 ----IGMSVGRGSGHTMVPTIMGIIRLWGIRILLGYILAFTIGLGSLGVWISMSLSNVVAGLLMII 450
Cdd:PRK01766 372 aiqvIGSGALRGYKDTRVIFFITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLL 437
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
30-191 |
9.38e-17 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 77.61 E-value: 9.38e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 30 PLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQVMPTFMLWNSIAQGLMAANLALITQLLGARRYDEARKYVSFFVSATL 109
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 110 LINSVVSIIYFILRPMIFSYIVRTPPLLyNDTLTYSGIITLDIVFSAFTLTYSTILQSIGDTRTPALINFGAASMNMVLD 189
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVL-ALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 218765129 190 PI 191
Cdd:pfam01554 160 YL 161
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
255-455 |
1.30e-16 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 81.73 E-value: 1.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 255 LRIGAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAFKS 334
Cdd:COG0534 11 LRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARRVLGQA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 335 MLYIGVSTLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGIIRLwGI 414
Cdd:COG0534 91 LLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGN-VL 169
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 218765129 415 RILLGYILAFTIGLGSLGVWISMSLSNVVAGLLMIIWVARG 455
Cdd:COG0534 170 NIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRK 210
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
255-460 |
4.70e-16 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 79.86 E-value: 4.70e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 255 LRIGAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAFKS 334
Cdd:cd13137 4 WSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRALGQS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 335 MLYIGVSTLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGIIRLwGI 414
Cdd:cd13137 84 LLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVN-VL 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 218765129 415 RILLGYILAFTI----GLGSLGVWISMSLSNVVAGLLMIIWVARGGWAIP 460
Cdd:cd13137 163 NIVLDYVLIFGLwgfpGLGVAGAALATVISRVVGALLLLFLLLRGRLPIK 212
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
260-421 |
2.21e-13 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 67.59 E-value: 2.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 260 PVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAFKSMLYIG 339
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 340 VSTLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGIIRLwGIRILLG 419
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISL-LLNIPLN 159
|
..
gi 218765129 420 YI 421
Cdd:pfam01554 160 YL 161
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
19-234 |
4.16e-10 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 61.37 E-value: 4.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 19 SIGRTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQVMPTFMLWNSIAQGLMAANLALITQLLGARRYDEAR 98
Cdd:cd13137 223 KIIKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEAR 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 99 KYVSFFVSATLLINSVVSIIYFILRPMIFSYIVRTPPLLYNDTLtYSGIITLDIVFSAFTLTYSTILQSIGDTRTPALIN 178
Cdd:cd13137 303 RYGKRALRLGVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVL-YLRIVALSQPFLAISFVLSGALRGAGDTRPPLIIN 381
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 218765129 179 FGAASMNMVLdPIFILGVGINgsmlippMGVAGAAYATILSRFIGLLLLYDRLNKK 234
Cdd:cd13137 382 LISMWLVRLP-LAYLLGFVLG-------LGLTGIWLAMFVDTIVRAILLLYRFRKG 429
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
167-439 |
2.13e-09 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 59.37 E-value: 2.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 167 SIGDTRTPALINFGAASMNMVLDPIFIlgvgiNGSMLIPPMGVAGAAYAT-ILSRFIGLLL-LYDRLNKKY-PYLKPRLT 243
Cdd:PRK00187 153 ALGRAGPVMVISLAGAVANLLLNYALI-----EGWFGLPKLGLMGIGLVTaLVSNGMALALaLYIRRHPAYaAYPLRKGL 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 244 LKIESDWLAKNLRIGAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGL 323
Cdd:PRK00187 228 SRPSRAALRELWRLGLPIGGTYAVEVGLFTFAALCMGALGSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGR 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 324 IDRARKVAFKSMLYIGVSTLIGSSIVYMLREAFISVFTD-NQVILSEADRFITVFLPSIVFFALF----FIGMSVGRGSG 398
Cdd:PRK00187 308 LLEARRAGRVGIGFGAVVMLLFAGLFWLLPEAIIGLFLDrNDPAFAEIVQLAVSLLAVAAWFELFdgtqTIAMGAIRGLK 387
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 218765129 399 HTMVPTIMGIIRLWGIRILLGYILAFTIGLGSLGVWISMSL 439
Cdd:PRK00187 388 DARTTFLIGLACYWLVGAPLAWLLAFTLGWGAVGVWWGLAL 428
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
10-237 |
3.47e-08 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 55.55 E-value: 3.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 10 ENRERILYGSIGRTLLWLGLPLMVVQLVNVSYNIVDTYWLSR------YSEIAYAV-----PRQVMPTFMLWNSIAQGLM 78
Cdd:cd13124 212 SPRSKISTKEILKELLSYAIPITLSSLILPLLQLIDSFTVPRrlqaagLSESEATAlygilTGRAQPLVQLPTVIATALS 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 79 AANLALITQLLGARRYDEARKYVSFFVSATLLINSVVSIIYFILRPMIFSyivrtppLLYNDTLTYS--GIITLDIVFSA 156
Cdd:cd13124 292 TSLVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINT-------LLFGDSEGGLilQILAPSILFLS 364
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 157 FTLTYSTILQSIGDTRTPALINFGAASMNMVLDpifilgvgingSMLIPPMGVAGAAYATILSRFIGLLLLYDRLNKKYP 236
Cdd:cd13124 365 LQQVTAAILQGLGKVKIPVINLLIGLLVKIVLN-----------YVLIPIFGIYGAAIATVIGFLVAALLNLRALKKLLG 433
|
.
gi 218765129 237 Y 237
Cdd:cd13124 434 F 434
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
182-454 |
9.20e-08 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 54.23 E-value: 9.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 182 ASMNMVLDPIFILGVGingsmlippMGVAGAAYATILSRFIGLLL-----LYDRLNKKYPYLKPRLTLKIesdwLAKNLR 256
Cdd:PRK09575 172 ALINIVLDYLFIGWLD---------WGLTGAAIATALAQLVVTVLglgyfFSSRANIRLTLKELRFNWSL----APKIVL 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 257 IGAPVTLMMASNSLAFMFQNALINQFGE--YVAAAAAIGLIMMdLADATLWGFTSSIAVMVGQALGAGLIDRARK---VA 331
Cdd:PRK09575 239 LGSSSFFMYLYGSFVVALHNRLFMEYGSalTVGAYAIVGYLMV-LYYLVAEGIAEGMQPPVSYYFGARQYDNIKKllkLA 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 332 FKSMLYIGVSTLIgssIVYMLREAFISVFTDN-QVILSEADRFITVFLpsivfFALFFIG---------MSVGRGsGHTM 401
Cdd:PRK09575 318 MKVTVLAGIAWVL---LLNLFPETMIALFNSGdSELIAETIVGIRLHL-----FAMFLDGflvlasayfMAVNQG-GKAL 388
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 218765129 402 VPTIMGIIrlwgIRILLGYILAFTIGLGslGVWISMSLSNVVAGLLMIIWVAR 454
Cdd:PRK09575 389 FISIGNML----IQLPFLFILPKWLGVD--GVWLAMPLSNIALSLVVAPMLWR 435
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
22-234 |
1.49e-07 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 53.61 E-value: 1.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 22 RTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSE-----IAYAVPRQVMPTFMlwnsIAQGLMAANLALITQLLGARRYDE 96
Cdd:cd13123 215 RRVLKLMLPALLGVSVSQINLLVDTILASFLPEgsisaLYYADRLYQLPLGI----FGVAIATALLPRLSRLAAAGDLDE 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 97 ARKYVSFFVSATLLINSVVSIIYFILRPMIFSYIVRTPPLLYNDTLTYSGIIT---LDIVFSAFTLTYSTILQSIGDTRT 173
Cdd:cd13123 291 FRRTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLFERGAFTAEDTLMTASALAayaLGLPAFALVKLLSRAFYALKDTKT 370
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 218765129 174 PALINFGAASMNMVLDPIfilgvgingsmLIPPMGVAGAAYATILSRFIGLLLLYDRLNKK 234
Cdd:cd13123 371 PVKIAVIAVAVNILLNLL-----------LIKPLGHVGLALATSLSAWVNALLLLVLLRRR 420
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
255-454 |
2.94e-07 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 52.50 E-value: 2.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 255 LRIGAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLIMMDLADATLWGFTSSIAVMVGQALGAGLIDRARKvAFKS 334
Cdd:cd13131 6 LRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRR-AVRQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 335 MLYIGVSTLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGIIRLwGI 414
Cdd:cd13131 85 GLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLAL-VL 163
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 218765129 415 RILLGYILAFTIG----LGSLGVWISMSLSNVVAGLLMIIWVAR 454
Cdd:cd13131 164 NIPLNYVLIFGKFglpaLGGAGAGLATAIVYWLMFLALAFYIRR 207
|
|
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
2-237 |
2.97e-07 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 52.86 E-value: 2.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 2 IEKMMRIEENRERILYGSIGRTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQ-----------VMPTFMLW 70
Cdd:COG5841 213 LKRLLEKSKTKSKESSKDILKELLRIAIPITLSSLVLPLFQLIDSFTVPRRLQAAGLSASEatslygilsgmAQPLVNLP 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 71 NSIAQGLMAANLALITQLLGARRYDEARKYVSFFVSATLLINSVVSIIYFILRPMIFSyivrtppLLYNDTL--TYSGII 148
Cdd:COG5841 293 TVLATALATSLVPAISEAFAKKDRKLVRRRINQALRLTLLIGLPAAVGLAVLAEPINT-------LLFGNPEggGILAIL 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 149 TLDIVFSAFTLTYSTILQSIGDTRTPALINFGAASMNMVLDPIfilgvgingsmLIPPMGVAGAAYATILSRFIGLLLLY 228
Cdd:COG5841 366 APSAIFLSLQQVTTGILQGLGKQKIPVINLLIGLLVKIILNYL-----------LVPLFGIYGAALATVIGYLVAAILNL 434
|
....*....
gi 218765129 229 DRLNKKYPY 237
Cdd:COG5841 435 AALKKYTGF 443
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
24-228 |
1.15e-06 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 50.33 E-value: 1.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 24 LLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEIA----YAVPRQVMptfMLWNSIAQGLMAANLALITQLLGARRYDEARK 99
Cdd:COG2244 175 VLKYSLPLLLSGLLGLLLTNLDRLLLGALLGPAavgiYSAAYRLA---SLLLLLITALSQVLFPRLSRLLAEGDREELRR 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 100 YVSFFVSATLLINSVVSIIYFILRPMIFSYIVRTPpllYNDTLTYSGIITLDIVFSAFTLTYSTILQSIGDTRTPALINF 179
Cdd:COG2244 252 LYRKALRLLLLLGLPLALGLALLAPPLLSLLFGPE---YAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISL 328
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 218765129 180 GAASMNMVLDPIfilgvgingsmLIPPMGVAGAAYATILSRFIGLLLLY 228
Cdd:COG2244 329 IGAVLNLVLNLL-----------LIPRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
22-128 |
2.65e-06 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 49.17 E-value: 2.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 22 RTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQVMPTFMLWNSIAQGLMAANLALITQLLGARRYDEARKYV 101
Cdd:TIGR00797 216 KRLLKLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVA 295
|
90 100
....*....|....*....|....*..
gi 218765129 102 SFFVSATLLINSVVSIIYFILRPMIFS 128
Cdd:TIGR00797 296 RVALKLSLLLGLVLAIILILFREFIAR 322
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
142-457 |
3.59e-06 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 49.35 E-value: 3.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 142 LTYSGIITLDIVFSAFTLTYSTILQSIGDTRTPALINFGAASMNMVLDPIFILGVGIngsmlIPPMGVAGAAYATILSRF 221
Cdd:PRK10189 150 LTYLELTVWSYPAAAITLIGSGALRGAGNTKIPLLINGGMNILNIIISSILIYGLFS-----WQGLGFVGAGLGLTISRY 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 222 IGLLLLYDRLNKKY-PYLkpRLTLK-----IESDWLAKNLRIGAPVTLMMASNSLAFMFQNALINQFGEYVAAAAAIGLI 295
Cdd:PRK10189 225 IGAVAIIWVLMIGFnPAL--RISLKsyfkpLNFAIIWEVMGIGIPASIESVLFNGGKLLTQMFVAGMGTSVIAGNFIAFS 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 296 MMDLADATLWGFTSSIAVMVGQALGAGLIDRARKVafksMLYIGVSTLIGSSIVYMLREAFI----SVFTDNQVILSEAD 371
Cdd:PRK10189 303 IAALINLPGNALGSASTIITGTRLGKGQIAQAERQ----LRHVFWLSTLGLTAIAWLSAPFAgllaSFYTQDPDVKHVVK 378
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 372 RFI---TVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGiirLWGIRILLGYILAFTIGLGSLGVWISMSLSNVVAGLLM 448
Cdd:PRK10189 379 ILIwlnALFMPIWAASWVLPAGLKGARDARYAMWVSMLG---MWGCRVVAGYILGIMLGFGVVGVWMGMFLDWAVRGVLF 455
|
....*....
gi 218765129 449 IIWVARGGW 457
Cdd:PRK10189 456 YWRMVSGRW 464
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
22-245 |
3.13e-05 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 46.30 E-value: 3.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 22 RTLLWLGLPLMVVQLVNVSYNIVDTYWLSRYSEIAYAVPRQVMPTFMLWNSI-AQGLMAANLALITQLLGARRYDEARKY 100
Cdd:COG0728 222 RRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSVSALYYADRLYQLPLGLfGVAIGTALLPRLSRAAAAGDLEEFRRT 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 101 VSFFVSATLLINSVVSIIYFILRPMIFSYIVRTPPLLYNDTLTYSGIIT---LDIVFSAFTLTYSTILQSIGDTRTPALI 177
Cdd:COG0728 302 LSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFERGAFTAEDTALTALALAayaLGLPAFALVKVLARAFYARQDTRTPVRI 381
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 218765129 178 NFGAASMNMVLDPIfilgvgingsmLIPPMGVAGAAYATILSRFIGLLLLYDRLNKKYPYLKPRLTLK 245
Cdd:COG0728 382 AVIAVVVNIVLNLL-----------LVPPLGHAGLALATSLSALVNALLLLVLLRRRLGGLPLRGILR 438
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
22-228 |
4.28e-05 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 45.61 E-value: 4.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 22 RTLLWLGLPLMVVQLVNVSYNIVDTYWLSRY-SEIAYAVPRQVMPTFMLWNSIAQGLMAANLALITQLLgARRYDEARKY 100
Cdd:cd13128 206 KELLRFSIPLALSGIFSLIYTRIDTIMLGYFlGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELY-KNDKDELKKL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 101 VSFFVSATLLINSVVSIIYFILRPMIFSYIVRTPPLLYNDTLTysgIITLDIVFSAFTLTYSTILQSIGDTRTPALINFG 180
Cdd:cd13128 285 LKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYLPAALVLQ---ILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLI 361
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 218765129 181 AASMNMVLDpifilgvgingSMLIPPMGVAGAAYATILSRFIGLLLLY 228
Cdd:cd13128 362 GALLNVILN-----------LLLIPKYGIIGAAIATLISEFIIFILLL 398
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
207-454 |
5.56e-05 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 45.54 E-value: 5.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 207 MGVAGAAYATILSRFIGLLLLYDRLNKKYPYLKPRLTLKIESDWLAKN-----LRIGAPVTLMMASNSL-----AFMFQN 276
Cdd:cd13124 174 YAAAGATFGAVIGALAGLLVLLYYYRKKRRELKRLLRKSPRSKISTKEilkelLSYAIPITLSSLILPLlqlidSFTVPR 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 277 ALINQFGEYVAAAAAIG--------LIMMDLAdatlwgFTSSIAV----MVGQALGAGLIDRARKVAFKSMlyiGVSTLI 344
Cdd:cd13124 254 RLQAAGLSESEATALYGiltgraqpLVQLPTV------IATALSTslvpAISEAYAKGDKKELRRRINQAL---RLTLLI 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 345 G--SSIVYML--REAFISVFTDnqvilSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVP---TIMGIIrlwgIRIL 417
Cdd:cd13124 325 GlpAAVGLAVlaEPINTLLFGD-----SEGGLILQILAPSILFLSLQQVTAAILQGLGKVKIPvinLLIGLL----VKIV 395
|
250 260 270
....*....|....*....|....*....|....*..
gi 218765129 418 LGYILafTIGLGSLGVWISMSLSNVVAGLLMIIWVAR 454
Cdd:cd13124 396 LNYVL--IPIFGIYGAAIATVIGFLVAALLNLRALKK 430
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
73-242 |
1.36e-04 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 44.20 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 73 IAQGLMAANLALITQLLGARRYDEARKYVSFFVSATLLINSVVSIIYFILRPMIFSYIVRTPPLLYNDTLTYSGII---T 149
Cdd:pfam03023 249 FGVSISTVLLPRLSRHAADGDWDEFRDLLDQAIRLTLLLMIPVSFGLLVLSIPIVSLLFERGNFSPEDVTATAEVLaayA 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 150 LDIVFSAFTLTYSTILQSIGDTRTPALINFGAASMNMVLDPIfilgvgingsmLIPPMGVAGAAYATILSRFIGLLLLYD 229
Cdd:pfam03023 329 LGLIPYALVKLLSRVFYAREDTKTPFKISLISAVLNILLSLL-----------LLPPLGVAGLALATSLSSLIGLVFLYY 397
|
170
....*....|...
gi 218765129 230 RLNKKYPYLKPRL 242
Cdd:pfam03023 398 ILRKRLGGFDLRG 410
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
255-463 |
1.83e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 43.65 E-value: 1.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 255 LRIGAPVTLMMASNSLAFMFQNALINQFGEYvAAAAAIGLIM--MDLADATLWGFTSSIAVMVGQALGAGLIDRARKVAF 332
Cdd:cd13143 7 LKFALPAIIGMLVNGLYNIVDGIFVGHGVGA-LALAAVNLVFpiIMLLMALGLMIGVGGASLISRRLGAGDREKANRIFS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 333 KSMLYIGVSTLIGSSIVYMLREAFISVFTDNQVILSEADRFITVFLPSIVFFALFFIGMSVGRGSGHTMVPTIMGIIRLw 412
Cdd:cd13143 86 TALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGA- 164
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 218765129 413 GIRILLGYILAFTIGLGSLGVWISMSLSNVVAGLLMIIWVARGGWAIPVIK 463
Cdd:cd13143 165 VLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSL 215
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
84-454 |
4.18e-04 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 42.44 E-value: 4.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 84 LITQLLGARRYDEARKYVSFFVSATLLINSVVSIIYFILRPMIFSYIV-RTPPLLYNDTLTYSGIITLDIVFSAFTLTYS 162
Cdd:cd13123 57 VFSEYLEKEGEEEARRFASRVLTLLLLVLLLLTLLGILFAPLLVKLLApGFSGDKFELAVALTRIMFPYLLFISLSALLG 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 163 TILQSIGDTRTPAlinFGAASMNMVLdpifILGVGIngSMLIPPMGVAGAAYATILSRFIGLLLLYDRLNKKYPYLKPRL 242
Cdd:cd13123 137 GILNAHGRFFAPA---LAPVLLNLVI----IAGLLL--LAPLFDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPRL 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 243 TLKIESdwLAKNLRIGAPVTLMMASNSLAFMFQNALINQFGEYVAAAaaiglimMDLADaTLWGF-TSSIAVMVGQAL-- 319
Cdd:cd13123 208 DFRDPG--VRRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSISA-------LYYAD-RLYQLpLGIFGVAIATALlp 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 320 ------GAGLIDRARKVAFKSMLYIGVSTLIGSSIVYMLREAFISV------FTDNQVIL-SEAdrfITVFLPSIVFFAL 386
Cdd:cd13123 278 rlsrlaAAGDLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLlfergaFTAEDTLMtASA---LAAYALGLPAFAL 354
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 218765129 387 FFIGMSVGRGSGHTMVPTIMGIIRLwGIRILLGYILAFTIGLGSLGvwISMSLSNVVAGLLMIIWVAR 454
Cdd:cd13123 355 VKLLSRAFYALKDTKTPVKIAVIAV-AVNILLNLLLIKPLGHVGLA--LATSLSAWVNALLLLVLLRR 419
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
147-244 |
7.69e-04 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 39.86 E-value: 7.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 147 IITLDIVFSAFTLTYSTILQSIGDTRTPALINFGAASMNMVLDPIfilgvgingsmLIPPMGVAGAAYATILSRFIGLLL 226
Cdd:pfam14667 4 ILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLL-----------LIPLFGIVGAAIATVISLLVVALL 72
|
90
....*....|....*...
gi 218765129 227 LYDRLNKKYPYLKPRLTL 244
Cdd:pfam14667 73 NLYYLRRYLGLRLLLRRL 90
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
84-460 |
2.93e-03 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 40.13 E-value: 2.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 84 LITQLLGARRYDEARKYVSFFVSATLLINSVVSIIYFILRPMIFSYIVRT-PPLLYNDTLTYSGIITLDIVFSAFTLTYS 162
Cdd:COG0728 64 VLAEALEKEGEEEARRFASRVLTLLLLVLLVLTLLGILFAPLLVKLLAPGfDPEKFALAVALTRIMFPYILFIGLSALLG 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 163 TILQSIGdtrtpaliNFGAASMNMVLDPIFILGVGINGSMLIPPmGVAGAAYATILSRFIGLLLLYdrlnkkyPYLK--- 239
Cdd:COG0728 144 GVLNARG--------RFAAPALAPVLLNLVIIAGLLLLAPLFGP-GIYALAWGVLLGGVLQLLIQL-------PALRrlg 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 240 --PRLTLKIESDWLAKNLRIGAPVTLMMASNSLAFMFQNALINQFGEyvAAAAAiglimMDLADaTLWGF-TSSIAVMVG 316
Cdd:COG0728 208 lrLRPRFDLRDPGVRRVLKLMLPALLGVSVSQINLLVDTILASFLPE--GSVSA-----LYYAD-RLYQLpLGLFGVAIG 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218765129 317 QAL--------GAGLIDRARKVAFKSMLYIGVSTLIGSSIVYMLREAFISV------FTDNQVILSEadRFITVFLPSIV 382
Cdd:COG0728 280 TALlprlsraaAAGDLEEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLlfergaFTAEDTALTA--LALAAYALGLP 357
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 218765129 383 FFALFFIGMSVGRGSGHTMVPTIMGIIRLwGIRILLGYILAFTIGLGSLGvwISMSLSNVVAGLLMIIWVARGGWAIP 460
Cdd:COG0728 358 AFALVKVLARAFYARQDTRTPVRIAVIAV-VVNIVLNLLLVPPLGHAGLA--LATSLSALVNALLLLVLLRRRLGGLP 432
|
|
| |
