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Conserved domains on  [gi|156618060|gb|ABU87900|]
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skint 5 isoform b precursor [Mus musculus]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 28-141 5.22e-45

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05713:

Pssm-ID: 472250  Cd Length: 114  Bit Score: 158.12  E-value: 5.22e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156618060   28 FTVNGLESPVLVPLDGNLELSCQLSPPQQAKHMEIRWFKNRYSEPVYLYRNGKDLFGEIVYKYVERTELLKDDIGKGKVT 107
Cdd:cd05713     1 FSVIGPTEPILALVGEDAELPCHLSPKMSAEHMEVRWFRSQFSPVVHLYRDGQDQEEEQMPEYRGRTELLKDAIAEGSVA 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 156618060  108 LRIFKVTSVDSGSYHCFFKDGKFYEEHIIDVKVT 141
Cdd:cd05713    81 LRIHNVRPSDEGQYTCFFRSGSFYEEATLELKVA 114
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 154-220 7.90e-06

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd16083:

Pssm-ID: 472250  Cd Length: 91  Bit Score: 45.53  E-value: 7.90e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 156618060  154 PNIKgvRLECHSGGWFPQPHMEWRDSkGEYIPATSKSHSQD-ENEFFNMTMDL-FIKSNSHwSATCYIQ 220
Cdd:cd16083    14 PNIK--RIICSTSGGFPEPRLSWLEN-GEELNAINTTVSQDpETELYTVSSELdFNVTYNH-SIVCLIK 78
DRIM super family cl06529
Down-regulated in metastasis; These eukaryotic proteins include DRIM (Down-Regulated In ...
 1034-1173 4.41e-05

Down-regulated in metastasis; These eukaryotic proteins include DRIM (Down-Regulated In Metastasis), which is differentially expressed in metastatic and non-metastatic human breast carcinoma cells. It is believed to be involved in processing of non-coding RNA.


The actual alignment was detected with superfamily member pfam07539:

Pssm-ID: 462198  Cd Length: 609  Bit Score: 47.96  E-value: 4.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156618060  1034 ILQSSSVKKETKEFVLYIIESIL-HSSSVHQETKDLLFDRVQLILESSSvqqglkcLLLNMIQVIFQRTSVQKemKDLLF 1112
Cdd:pfam07539  325 LLSNPKAKPSVVLFVLDIVENLLtLADEEDEEEEDSEDIGSELLLPHVS-------SLLQHLPALLERSKTPS--KELLS 395

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 156618060  1113 NRIPLILE-SSSVQ-QETKDKLLDIIQSILQRTS--VQEETKDKLLDIIQSILQRSSVQKDTIDT 1173
Cdd:pfam07539  396 RELSILSRlAPYVTdSEQASSLLDLLLPLLRKPSrrVSPKTKVDLLKILSNLLPLYDCSWDDILP 460
 
Name Accession Description Interval E-value
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 28-141 5.22e-45

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 158.12  E-value: 5.22e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156618060   28 FTVNGLESPVLVPLDGNLELSCQLSPPQQAKHMEIRWFKNRYSEPVYLYRNGKDLFGEIVYKYVERTELLKDDIGKGKVT 107
Cdd:cd05713     1 FSVIGPTEPILALVGEDAELPCHLSPKMSAEHMEVRWFRSQFSPVVHLYRDGQDQEEEQMPEYRGRTELLKDAIAEGSVA 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 156618060  108 LRIFKVTSVDSGSYHCFFKDGKFYEEHIIDVKVT 141
Cdd:cd05713    81 LRIHNVRPSDEGQYTCFFRSGSFYEEATLELKVA 114
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 34-141 2.08e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 64.79  E-value: 2.08e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156618060    34 ESPVLVPLDGNLELSCQLSPPQQAKHMEIRWFK----NRYSEPVYLYRNGKDLFgeivyKYVERTELLKDDIgKGKVTLR 109
Cdd:pfam07686    3 PREVTVALGGSVTLPCTYSSSMSEASTSVYWYRqppgKGPTFLIAYYSNGSEEG-----VKKGRFSGRGDPS-NGDGSLT 76

                           90       100       110
                   ....*....|....*....|....*....|...
gi 156618060   110 IFKVTSVDSGSYHC-FFKDGKFYEEHIIDVKVT 141
Cdd:pfam07686   77 IQNLTLSDSGTYTCaVIPSGEGVFGKGTRLTVL 109
IGv smart00406
Immunoglobulin V-Type;
44-125 7.55e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 45.45  E-value: 7.55e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156618060     44 NLELSCQLSPPQQAKhMEIRWFKNRYSEPVY-LYRNGKDLFGEIVYKYVERTELLKDDiGKGKVTLRIFKVTSVDSGSYH 122
Cdd:smart00406    1 SVTLSCKFSGSTFSS-YYVSWVRQPPGKGLEwLGYIGSNGSSYYQESYKGRFTISKDT-SKNDVSLTISNLRVEDTGTYY 78


                    ...
gi 156618060    123 CFF 125
Cdd:smart00406   79 CAV 81
IgC1_CD80 cd16083
Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) ...
 154-220 7.90e-06

Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin constant (IgC)-like domain of the antigen receptor Cluster of Differentiation (CD) 80. CD80 (also known as glycoprotein B7-1) and CD86 (also known as glycoprotein B7-2) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. CD80 contains two Ig-like domains, an amino-terminal immunoglobulin variable (IgV)-like domain characteristic of adhesion molecules, and a membrane proximal immunoglobulin constant (IgC)-like domain similar to the constant domains of antigen receptors. Members of the Ig family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, and the IgC domain is involved in oligomerization and molecular interactions.


Pssm-ID: 409505  Cd Length: 91  Bit Score: 45.53  E-value: 7.90e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 156618060  154 PNIKgvRLECHSGGWFPQPHMEWRDSkGEYIPATSKSHSQD-ENEFFNMTMDL-FIKSNSHwSATCYIQ 220
Cdd:cd16083    14 PNIK--RIICSTSGGFPEPRLSWLEN-GEELNAINTTVSQDpETELYTVSSELdFNVTYNH-SIVCLIK 78
DRIM pfam07539
Down-regulated in metastasis; These eukaryotic proteins include DRIM (Down-Regulated In ...
 1034-1173 4.41e-05

Down-regulated in metastasis; These eukaryotic proteins include DRIM (Down-Regulated In Metastasis), which is differentially expressed in metastatic and non-metastatic human breast carcinoma cells. It is believed to be involved in processing of non-coding RNA.


Pssm-ID: 462198  Cd Length: 609  Bit Score: 47.96  E-value: 4.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156618060  1034 ILQSSSVKKETKEFVLYIIESIL-HSSSVHQETKDLLFDRVQLILESSSvqqglkcLLLNMIQVIFQRTSVQKemKDLLF 1112
Cdd:pfam07539  325 LLSNPKAKPSVVLFVLDIVENLLtLADEEDEEEEDSEDIGSELLLPHVS-------SLLQHLPALLERSKTPS--KELLS 395

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 156618060  1113 NRIPLILE-SSSVQ-QETKDKLLDIIQSILQRTS--VQEETKDKLLDIIQSILQRSSVQKDTIDT 1173
Cdd:pfam07539  396 RELSILSRlAPYVTdSEQASSLLDLLLPLLRKPSrrVSPKTKVDLLKILSNLLPLYDCSWDDILP 460
 
Name Accession Description Interval E-value
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 28-141 5.22e-45

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 158.12  E-value: 5.22e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156618060   28 FTVNGLESPVLVPLDGNLELSCQLSPPQQAKHMEIRWFKNRYSEPVYLYRNGKDLFGEIVYKYVERTELLKDDIGKGKVT 107
Cdd:cd05713     1 FSVIGPTEPILALVGEDAELPCHLSPKMSAEHMEVRWFRSQFSPVVHLYRDGQDQEEEQMPEYRGRTELLKDAIAEGSVA 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 156618060  108 LRIFKVTSVDSGSYHCFFKDGKFYEEHIIDVKVT 141
Cdd:cd05713    81 LRIHNVRPSDEGQYTCFFRSGSFYEEATLELKVA 114
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 34-141 2.08e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 64.79  E-value: 2.08e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156618060    34 ESPVLVPLDGNLELSCQLSPPQQAKHMEIRWFK----NRYSEPVYLYRNGKDLFgeivyKYVERTELLKDDIgKGKVTLR 109
Cdd:pfam07686    3 PREVTVALGGSVTLPCTYSSSMSEASTSVYWYRqppgKGPTFLIAYYSNGSEEG-----VKKGRFSGRGDPS-NGDGSLT 76

                           90       100       110
                   ....*....|....*....|....*....|...
gi 156618060   110 IFKVTSVDSGSYHC-FFKDGKFYEEHIIDVKVT 141
Cdd:pfam07686   77 IQNLTLSDSGTYTCaVIPSGEGVFGKGTRLTVL 109
IgV_HHLA2 cd16091
Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...
 34-140 3.11e-08

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.


Pssm-ID: 409512  Cd Length: 107  Bit Score: 53.16  E-value: 3.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156618060   34 ESPVLVPLDGNLELSCQLSPpqqAKHMEIRWFKNRYSEPVYLYRNGKDLFGEIVYKYVERTELLKDDIGKGKVTLRIFKV 113
Cdd:cd16091     4 EVIVVCLLSEDCILPCSFTP---GSEVVIHWYKQDSDIKVHSYYYGKDQLESQDQRYRNRTSLFKDQISNGNASLLLRRV 80

                          90       100
                  ....*....|....*....|....*..
gi 156618060  114 TSVDSGSYHCFFKDGKFYEEHIIDVKV 140
Cdd:cd16091    81 QLQDEGRYKCYTSTIIGNQESFVNLKV 107
IgV_B7-H4 cd20984
Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the ...
 47-129 1.33e-06

Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H4 (also known as B7-S1, B7x, or Vtcn1). B7-H4 is one of the B7 family of immune-regulatory ligands that act as negative regulators of T cell function; it contains one IgV domain and one IgC domain. The B7-family consists of structurally related cell-surface protein ligands, which bind to receptors on lymphocytes that regulate immune responses. The binding of B7-H4 to unidentified receptors results in the inhibition of TCR-mediated T cell proliferation, cell-cycle progression and IL-2 production. As a co-inhibitory molecule, B7-H4 is widely expressed in tumor tissues and its expression is significantly associated with poor prognosis in human cancers such as glioma, pancreatic cancer, oral squamous cell carcinoma, renal cell carcinoma, and lung cancer.


Pssm-ID: 409576  Cd Length: 110  Bit Score: 48.36  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156618060   47 LSCQLSPPQQAKHMEIRWFKNRYSEPVYLYRNGKDLFGEIVYKYVERTELLKDDIGKGKVTLRIFKVTSVDSGSYHCFFK 126
Cdd:cd20984    17 LSCTFTPDIKLSDIVIQWLKEGDSGLVHEFKEGKDELSRQSPMFRGRTSLFADQVHVGNASLRLKNVQLTDAGTYLCIIS 96


                  ...
gi 156618060  127 DGK 129
Cdd:cd20984    97 NSK 99
IgV_B7-H3 cd20934
Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint ...
 34-124 1.60e-06

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.


Pssm-ID: 409528  Cd Length: 115  Bit Score: 48.37  E-value: 1.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156618060   34 ESPVLVPLDGNLELSCQLSPPQ--QAKHMEIRWFKNRYSEPVYLYRNGKDLFGEIVYKYVERTELLKDDIGKGKVTLRIF 111
Cdd:cd20934     4 EDPVVALVGTDATLRCSFSPEPgfSLAQLSVFWQLTDTKQLVHSFTESQDQGRDQGSAYANRTALFPDLLAQGNASLRLQ 83

                          90
                  ....*....|...
gi 156618060  112 KVTSVDSGSYHCF 124
Cdd:cd20934    84 RVRVADEGSYTCF 96
IGv smart00406
Immunoglobulin V-Type;
44-125 7.55e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 45.45  E-value: 7.55e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156618060     44 NLELSCQLSPPQQAKhMEIRWFKNRYSEPVY-LYRNGKDLFGEIVYKYVERTELLKDDiGKGKVTLRIFKVTSVDSGSYH 122
Cdd:smart00406    1 SVTLSCKFSGSTFSS-YYVSWVRQPPGKGLEwLGYIGSNGSSYYQESYKGRFTISKDT-SKNDVSLTISNLRVEDTGTYY 78


                    ...
gi 156618060    123 CFF 125
Cdd:smart00406   79 CAV 81
IgC1_CD80 cd16083
Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) ...
 154-220 7.90e-06

Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin constant (IgC)-like domain of the antigen receptor Cluster of Differentiation (CD) 80. CD80 (also known as glycoprotein B7-1) and CD86 (also known as glycoprotein B7-2) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. CD80 contains two Ig-like domains, an amino-terminal immunoglobulin variable (IgV)-like domain characteristic of adhesion molecules, and a membrane proximal immunoglobulin constant (IgC)-like domain similar to the constant domains of antigen receptors. Members of the Ig family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, and the IgC domain is involved in oligomerization and molecular interactions.


Pssm-ID: 409505  Cd Length: 91  Bit Score: 45.53  E-value: 7.90e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 156618060  154 PNIKgvRLECHSGGWFPQPHMEWRDSkGEYIPATSKSHSQD-ENEFFNMTMDL-FIKSNSHwSATCYIQ 220
Cdd:cd16083    14 PNIK--RIICSTSGGFPEPRLSWLEN-GEELNAINTTVSQDpETELYTVSSELdFNVTYNH-SIVCLIK 78
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 35-140 2.21e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.03  E-value: 2.21e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156618060     35 SPVLVPLDGNLELSCQLSPPqqaKHMEIRWFKNRYSEPvylyrngkdlfgeivyKYVERTELLKDdigKGKVTLRIFKVT 114
Cdd:smart00410    2 PSVTVKEGESVTLSCEASGS---PPPEVTWYKQGGKLL----------------AESGRFSVSRS---GSTSTLTISNVT 59

                            90       100
                    ....*....|....*....|....*.
gi 156618060    115 SVDSGSYHCFFKDGKFYEEHIIDVKV 140
Cdd:smart00410   60 PEDSGTYTCAATNSSGSASSGTTLTV 85
DRIM pfam07539
Down-regulated in metastasis; These eukaryotic proteins include DRIM (Down-Regulated In ...
 1034-1173 4.41e-05

Down-regulated in metastasis; These eukaryotic proteins include DRIM (Down-Regulated In Metastasis), which is differentially expressed in metastatic and non-metastatic human breast carcinoma cells. It is believed to be involved in processing of non-coding RNA.


Pssm-ID: 462198  Cd Length: 609  Bit Score: 47.96  E-value: 4.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156618060  1034 ILQSSSVKKETKEFVLYIIESIL-HSSSVHQETKDLLFDRVQLILESSSvqqglkcLLLNMIQVIFQRTSVQKemKDLLF 1112
Cdd:pfam07539  325 LLSNPKAKPSVVLFVLDIVENLLtLADEEDEEEEDSEDIGSELLLPHVS-------SLLQHLPALLERSKTPS--KELLS 395

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 156618060  1113 NRIPLILE-SSSVQ-QETKDKLLDIIQSILQRTS--VQEETKDKLLDIIQSILQRSSVQKDTIDT 1173
Cdd:pfam07539  396 RELSILSRlAPYVTdSEQASSLLDLLLPLLRKPSrrVSPKTKVDLLKILSNLLPLYDCSWDDILP 460
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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