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Conserved domains on  [gi|146217477|gb|ABQ10836|]
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ODZ4, partial [Mus musculus]

Protein Classification

RHS repeat protein( domain architecture ID 13545136)

RHS (rearrangement hotspot) repeat protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Tox-GHH pfam15636
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ...
290-367 3.28e-38

GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.


:

Pssm-ID: 464783  Cd Length: 78  Bit Score: 131.58  E-value: 3.28e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 146217477  290 EEKVRVLELARQRAVRQAWAREQQRLREGEEGLRAWTDGEKQQVLNTGRVQGYDGFFVTSVEQYPELSDSANNIHFMR 367
Cdd:pfam15636   1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
Rhs_assc_core super family cl37315
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
5-66 1.61e-08

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


The actual alignment was detected with superfamily member TIGR03696:

Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 50.96  E-value: 1.61e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 146217477    5 IGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkrlssnsivPF------HLYMFKNNNPISNS 66
Cdd:TIGR03696  18 LRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-------------PIglggglNLYAYVGNNPVNWV 72
 
Name Accession Description Interval E-value
Tox-GHH pfam15636
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ...
290-367 3.28e-38

GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.


Pssm-ID: 464783  Cd Length: 78  Bit Score: 131.58  E-value: 3.28e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 146217477  290 EEKVRVLELARQRAVRQAWAREQQRLREGEEGLRAWTDGEKQQVLNTGRVQGYDGFFVTSVEQYPELSDSANNIHFMR 367
Cdd:pfam15636   1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
Rhs_assc_core TIGR03696
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
5-66 1.61e-08

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 50.96  E-value: 1.61e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 146217477    5 IGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkrlssnsivPF------HLYMFKNNNPISNS 66
Cdd:TIGR03696  18 LRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-------------PIglggglNLYAYVGNNPVNWV 72
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
6-66 7.46e-06

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 48.21  E-value: 7.46e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146217477    6 GYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkrlssnSIVP---FHLYMFKNNNPISNS 66
Cdd:COG3209   967 RFTGQEYDAETGLYYNGARYYDPALGRFLSPD----------PIGLaggLNLYAYVGNNPVNYV 1020
 
Name Accession Description Interval E-value
Tox-GHH pfam15636
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ...
290-367 3.28e-38

GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.


Pssm-ID: 464783  Cd Length: 78  Bit Score: 131.58  E-value: 3.28e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 146217477  290 EEKVRVLELARQRAVRQAWAREQQRLREGEEGLRAWTDGEKQQVLNTGRVQGYDGFFVTSVEQYPELSDSANNIHFMR 367
Cdd:pfam15636   1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
Rhs_assc_core TIGR03696
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
5-66 1.61e-08

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 50.96  E-value: 1.61e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 146217477    5 IGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkrlssnsivPF------HLYMFKNNNPISNS 66
Cdd:TIGR03696  18 LRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-------------PIglggglNLYAYVGNNPVNWV 72
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
6-66 7.46e-06

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 48.21  E-value: 7.46e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146217477    6 GYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkrlssnSIVP---FHLYMFKNNNPISNS 66
Cdd:COG3209   967 RFTGQEYDAETGLYYNGARYYDPALGRFLSPD----------PIGLaggLNLYAYVGNNPVNYV 1020
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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