bile acid:sodium symporter (BASS) family protein, similar to Homo sapiens solute carrier family 10 (SLC10) proteins, which comprises influx transporters of bile acids, steroidal hormones, various drugs, and several other substrates
Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. ...
152-421
2.10e-50
Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+. Also in the family is ARC3 from S. cerevisiae; this is a putative transmembrane protein involved in resistance to arsenic compounds.
The actual alignment was detected with superfamily member TIGR00841:
Pssm-ID: 450274 Cd Length: 286 Bit Score: 172.13 E-value: 2.10e-50
bile acid transporter; The Bile Acid:Na+ Symporter (BASS) Family (TC 2.A.28) Functionally ...
152-421
2.10e-50
bile acid transporter; The Bile Acid:Na+ Symporter (BASS) Family (TC 2.A.28) Functionally characterized members of the BASS family catalyze Na+:bile acid symport. These systems have been identified in intestinal, liver and kidney tissues of animals. These symporters exhibit broad specificity, taking up a variety of non bile organic compounds as well as taurocholate and other bile salts. Functionally uncharacterised homologues are found in plants, yeast, archaea and bacteria. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 188087 Cd Length: 286 Bit Score: 172.13 E-value: 2.10e-50
Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. ...
152-323
2.90e-27
Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+. Also in the family is ARC3 from S. cerevisiae; this is a putative transmembrane protein involved in resistance to arsenic compounds.
Pssm-ID: 366796 Cd Length: 191 Bit Score: 107.38 E-value: 2.90e-27
bile acid transporter; The Bile Acid:Na+ Symporter (BASS) Family (TC 2.A.28) Functionally ...
152-421
2.10e-50
bile acid transporter; The Bile Acid:Na+ Symporter (BASS) Family (TC 2.A.28) Functionally characterized members of the BASS family catalyze Na+:bile acid symport. These systems have been identified in intestinal, liver and kidney tissues of animals. These symporters exhibit broad specificity, taking up a variety of non bile organic compounds as well as taurocholate and other bile salts. Functionally uncharacterised homologues are found in plants, yeast, archaea and bacteria. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 188087 Cd Length: 286 Bit Score: 172.13 E-value: 2.10e-50
Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. ...
152-323
2.90e-27
Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+. Also in the family is ARC3 from S. cerevisiae; this is a putative transmembrane protein involved in resistance to arsenic compounds.
Pssm-ID: 366796 Cd Length: 191 Bit Score: 107.38 E-value: 2.90e-27
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
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specific hits meet or exceed a domain-specific e-value threshold
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and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
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the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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