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Conserved domains on  [gi|68005616|gb|AAY84740|]
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apoptosis-inducing factor short isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NirB super family cl34210
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
147-318 1.32e-29

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


The actual alignment was detected with superfamily member COG1251:

Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 116.39  E-value: 1.32e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616 147 RSIRARDPGARVLIVSEDPELPYMRPPLSKELwfsddpnvtktlqfrqwNGK--ERSIYFQPPSFYvsaqdlpniENGGV 224
Cdd:COG1251  18 EELRKLDPDGEITVIGAEPHPPYNRPPLSKVL-----------------AGEtdEEDLLLRPADFY---------EENGI 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616 225 AVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAidrAGAEVKSRTTlFRKIGDFRALEKISREVKSITV 304
Cdd:COG1251  72 DLRLGTRVTAIDRAARTVTLADGETLPYDKLVLATGSRPRVPPI---PGADLPGVFT-LRTLDDADALRAALAPGKRVVV 147

                       170
                ....*....|....
gi 68005616 305 IGGGFLGSELACAL 318
Cdd:COG1251 148 IGGGLIGLEAAAAL 161
AIF-MLS super family cl25936
Mitochondria localization Sequence; This family contains a protein found in eukaryotes. ...
 51-128 1.77e-05

Mitochondria localization Sequence; This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localization sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.


The actual alignment was detected with superfamily member pfam14962:

Pssm-ID: 464407 [Multi-domain]  Cd Length: 192  Bit Score: 44.82  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616    51 RQMASS---GSSGGKMdnsVLVLIVGLSTIGAGAYAYKTIKEDQKRYNERVMGLG------LSPEEKQRRAIASATEGGS 121
Cdd:pfam14962  31 RRMSSNkfpGSSGSNM---IYYLVVGVTVSAGGYYTYKTVTSEQAKHTEHVTNLKektkaeLHPLQGEKENVAEAEKASS 107


                  ....*...
gi 68005616   122 -VPQIRAP 128
Cdd:pfam14962 108 eAPEVSVV 115
 
Name Accession Description Interval E-value
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
147-318 1.32e-29

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 116.39  E-value: 1.32e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616 147 RSIRARDPGARVLIVSEDPELPYMRPPLSKELwfsddpnvtktlqfrqwNGK--ERSIYFQPPSFYvsaqdlpniENGGV 224
Cdd:COG1251  18 EELRKLDPDGEITVIGAEPHPPYNRPPLSKVL-----------------AGEtdEEDLLLRPADFY---------EENGI 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616 225 AVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAidrAGAEVKSRTTlFRKIGDFRALEKISREVKSITV 304
Cdd:COG1251  72 DLRLGTRVTAIDRAARTVTLADGETLPYDKLVLATGSRPRVPPI---PGADLPGVFT-LRTLDDADALRAALAPGKRVVV 147

                       170
                ....*....|....
gi 68005616 305 IGGGFLGSELACAL 318
Cdd:COG1251 148 IGGGLIGLEAAAAL 161
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 149-318 3.83e-18

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 83.14  E-value: 3.83e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616   149 IRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPnvtktlqfrqwngkeRSIYFQPPSFYVSAQDLPNIENGGVAVLT 228
Cdd:pfam07992  17 LTLAQLGGKVTLIEDEGTCPYGGCVLSKALLGAAEA---------------PEIASLWADLYKRKEEVVKKLNNGIEVLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616   229 GKKVVHLD-----VRGNMVKLNDGSQITFEKCLIATGGTPRSLSAidrAGAEvKSRTTLFRKIGDFRALEKISREvKSIT 303
Cdd:pfam07992  82 GTEVVSIDpgakkVVLEELVDGDGETITYDRLVIATGARPRLPPI---PGVE-LNVGFLVRTLDSAEALRLKLLP-KRVV 156

                         170
                  ....*....|....*
gi 68005616   304 VIGGGFLGSELACAL 318
Cdd:pfam07992 157 VVGGGYIGVELAAAL 171
PRK09754 PRK09754
phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional
 148-321 1.60e-09

phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional


Pssm-ID: 170080 [Multi-domain]  Cd Length: 396  Bit Score: 58.40  E-value: 1.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616  148 SIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTktlqfrqwngkersiYFQPPSFYVSAQdlpnienggVAVL 227
Cdd:PRK09754  21 SLRQQGFTGELHLFSDERHLPYERPPLSKSMLLEDSPQLQ---------------QVLPANWWQENN---------VHLH 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616  228 TGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEVKSrttlFRKIGDFRALEKISREVKSITVIGG 307
Cdd:PRK09754  77 SGVTIKTLGRDTRELVLTNGESWHWDQLFIATGAAARPLPLLDALGERCFT----LRHAGDAARLREVLQPERSVVIVGA 152

                        170
                 ....*....|....*..
gi 68005616  308 GFLGSELA---CALGRK 321
Cdd:PRK09754 153 GTIGLELAasaTQRRCK 169
AIF-MLS pfam14962
Mitochondria localization Sequence; This family contains a protein found in eukaryotes. ...
 51-128 1.77e-05

Mitochondria localization Sequence; This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localization sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.


Pssm-ID: 464407 [Multi-domain]  Cd Length: 192  Bit Score: 44.82  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616    51 RQMASS---GSSGGKMdnsVLVLIVGLSTIGAGAYAYKTIKEDQKRYNERVMGLG------LSPEEKQRRAIASATEGGS 121
Cdd:pfam14962  31 RRMSSNkfpGSSGSNM---IYYLVVGVTVSAGGYYTYKTVTSEQAKHTEHVTNLKektkaeLHPLQGEKENVAEAEKASS 107


                  ....*...
gi 68005616   122 -VPQIRAP 128
Cdd:pfam14962 108 eAPEVSVV 115
vWA_transcription_factor_IIH_type cd01453
Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five ...
 47-121 4.28e-03

Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins contain a VWA domain. The p44 subunit of TFIIH functions as a DNA helicase in RNA polymerase II transcription initiation and DNA repair, and its transcriptional activity is dependent on its C-terminal Zn-binding domains. The function of the vWA domain is unclear, but may be involved in complex assembly. The MIDAS motif is not conserved in this sub-group.


Pssm-ID: 238730  Cd Length: 183  Bit Score: 37.70  E-value: 4.28e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68005616  47 LQMARQ----MASSGSsggkmdNSVLVLIVGLSTIGAGAYaYKTIKEdQKRYNERVMGLGLSPEEKQRRAIASATEGGS 121
Cdd:cd01453  92 LEMALEslkhMPSHGS------REVLIIFSSLSTCDPGNI-YETIDK-LKKENIRVSVIGLSAEMHICKEICKATNGTY 162
 
Name Accession Description Interval E-value
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
147-318 1.32e-29

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 116.39  E-value: 1.32e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616 147 RSIRARDPGARVLIVSEDPELPYMRPPLSKELwfsddpnvtktlqfrqwNGK--ERSIYFQPPSFYvsaqdlpniENGGV 224
Cdd:COG1251  18 EELRKLDPDGEITVIGAEPHPPYNRPPLSKVL-----------------AGEtdEEDLLLRPADFY---------EENGI 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616 225 AVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAidrAGAEVKSRTTlFRKIGDFRALEKISREVKSITV 304
Cdd:COG1251  72 DLRLGTRVTAIDRAARTVTLADGETLPYDKLVLATGSRPRVPPI---PGADLPGVFT-LRTLDDADALRAALAPGKRVVV 147

                       170
                ....*....|....
gi 68005616 305 IGGGFLGSELACAL 318
Cdd:COG1251 148 IGGGLIGLEAAAAL 161
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 149-318 3.83e-18

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 83.14  E-value: 3.83e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616   149 IRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPnvtktlqfrqwngkeRSIYFQPPSFYVSAQDLPNIENGGVAVLT 228
Cdd:pfam07992  17 LTLAQLGGKVTLIEDEGTCPYGGCVLSKALLGAAEA---------------PEIASLWADLYKRKEEVVKKLNNGIEVLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616   229 GKKVVHLD-----VRGNMVKLNDGSQITFEKCLIATGGTPRSLSAidrAGAEvKSRTTLFRKIGDFRALEKISREvKSIT 303
Cdd:pfam07992  82 GTEVVSIDpgakkVVLEELVDGDGETITYDRLVIATGARPRLPPI---PGVE-LNVGFLVRTLDSAEALRLKLLP-KRVV 156

                         170
                  ....*....|....*
gi 68005616   304 VIGGGFLGSELACAL 318
Cdd:pfam07992 157 VVGGGYIGVELAAAL 171
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 151-321 9.20e-17

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 79.47  E-value: 9.20e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616 151 ARDPGARVLIVSEDPELPYMRPPLSKELWFSDDpnvtktlqfrqwngKERSIYFQPPSFYVSAqdlpniengGVAVLTGK 230
Cdd:COG0446   1 RLGPDAEITVIEKGPHHSYQPCGLPYYVGGGIK--------------DPEDLLVRTPESFERK---------GIDVRTGT 57

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616 231 KVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLsAIDraGAEVKSRTTLfRKIGDFRAL-EKI-SREVKSITVIGGG 308
Cdd:COG0446  58 EVTAIDPEAKTVTLRDGETLSYDKLVLATGARPRPP-PIP--GLDLPGVFTL-RTLDDADALrEALkEFKGKRAVVIGGG 133

                       170
                ....*....|....*.
gi 68005616 309 FLGSELACAL---GRK 321
Cdd:COG0446 134 PIGLELAEALrkrGLK 149
PRK09754 PRK09754
phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional
 148-321 1.60e-09

phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional


Pssm-ID: 170080 [Multi-domain]  Cd Length: 396  Bit Score: 58.40  E-value: 1.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616  148 SIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTktlqfrqwngkersiYFQPPSFYVSAQdlpnienggVAVL 227
Cdd:PRK09754  21 SLRQQGFTGELHLFSDERHLPYERPPLSKSMLLEDSPQLQ---------------QVLPANWWQENN---------VHLH 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616  228 TGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEVKSrttlFRKIGDFRALEKISREVKSITVIGG 307
Cdd:PRK09754  77 SGVTIKTLGRDTRELVLTNGESWHWDQLFIATGAAARPLPLLDALGERCFT----LRHAGDAARLREVLQPERSVVIVGA 152

                        170
                 ....*....|....*..
gi 68005616  308 GFLGSELA---CALGRK 321
Cdd:PRK09754 153 GTIGLELAasaTQRRCK 169
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 219-320 4.92e-09

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 57.02  E-value: 4.92e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616 219 IENGGVAVLTGKKVVhldVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFrkigdfrALEKIsre 298
Cdd:COG1249 101 LKKNGVDVIRGRARF---VDPHTVEVTGGETLTADHIVIATGSRPRVPPIPGLDEVRVLTSDEAL-------ELEEL--- 167

                        90       100
                ....*....|....*....|..
gi 68005616 299 VKSITVIGGGFLGSELACALGR 320
Cdd:COG1249 168 PKSLVVIGGGYIGLEFAQIFAR 189
PRK14989 PRK14989
nitrite reductase subunit NirD; Provisional
 220-318 1.25e-07

nitrite reductase subunit NirD; Provisional


Pssm-ID: 184951 [Multi-domain]  Cd Length: 847  Bit Score: 53.20  E-value: 1.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616  220 ENGGVAVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPrSLSAIdrAGAEVKSrTTLFRKIGDFRALEKISREV 299
Cdd:PRK14989  70 EKHGIKVLVGERAITINRQEKVIHSSAGRTVFYDKLIMATGSYP-WIPPI--KGSETQD-CFVYRTIEDLNAIEACARRS 145

                         90
                 ....*....|....*....
gi 68005616  300 KSITVIGGGFLGSELACAL 318
Cdd:PRK14989 146 KRGAVVGGGLLGLEAAGAL 164
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
223-318 6.84e-07

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 50.13  E-value: 6.84e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616 223 GVAVLTGKkVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRsLSAIDraGAE-----VKSR---TTLFRKIgdFRALEK 294
Cdd:COG1252  70 GVRFIQGE-VTGIDPEARTVTLADGRTLSYDYLVIATGSVTN-FFGIP--GLAehalpLKTLedaLALRERL--LAAFER 143

                        90       100
                ....*....|....*....|....*
gi 68005616 295 ISREVK-SITVIGGGFLGSELACAL 318
Cdd:COG1252 144 AERRRLlTIVVVGGGPTGVELAGEL 168
AIF-MLS pfam14962
Mitochondria localization Sequence; This family contains a protein found in eukaryotes. ...
 51-128 1.77e-05

Mitochondria localization Sequence; This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localization sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.


Pssm-ID: 464407 [Multi-domain]  Cd Length: 192  Bit Score: 44.82  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616    51 RQMASS---GSSGGKMdnsVLVLIVGLSTIGAGAYAYKTIKEDQKRYNERVMGLG------LSPEEKQRRAIASATEGGS 121
Cdd:pfam14962  31 RRMSSNkfpGSSGSNM---IYYLVVGVTVSAGGYYTYKTVTSEQAKHTEHVTNLKektkaeLHPLQGEKENVAEAEKASS 107


                  ....*...
gi 68005616   122 -VPQIRAP 128
Cdd:pfam14962 108 eAPEVSVV 115
PRK09564 PRK09564
coenzyme A disulfide reductase; Reviewed
 223-318 4.16e-05

coenzyme A disulfide reductase; Reviewed


Pssm-ID: 181958 [Multi-domain]  Cd Length: 444  Bit Score: 45.03  E-value: 4.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616  223 GVAVLTGKKVVHLDVRGNMVK---LNDGSQI--TFEKCLIATGGTPrSLSAIDraGAEVKSRTTLfRKIGDFRALEKISR 297
Cdd:PRK09564  70 GIDVKTEHEVVKVDAKNKTITvknLKTGSIFndTYDKLMIATGARP-IIPPIK--NINLENVYTL-KSMEDGLALKELLK 145

                         90       100
                 ....*....|....*....|...
gi 68005616  298 --EVKSITVIGGGFLGSELACAL 318
Cdd:PRK09564 146 deEIKNIVIIGAGFIGLEAVEAA 168
PRK06116 PRK06116
glutathione reductase; Validated
 220-319 1.03e-04

glutathione reductase; Validated


Pssm-ID: 235701 [Multi-domain]  Cd Length: 450  Bit Score: 43.61  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616  220 ENGGVAVLTGKKVVhldVRGNMVKLNdGSQITFEKCLIATGGTPrslSAIDRAGAE--VKSRttlfrkigDFRALEKISr 297
Cdd:PRK06116 104 ENNGVDLIEGFARF---VDAHTVEVN-GERYTADHILIATGGRP---SIPDIPGAEygITSD--------GFFALEELP- 167

                         90       100
                 ....*....|....*....|....*
gi 68005616  298 evKSITVIGGGFLGSELAC---ALG 319
Cdd:PRK06116 168 --KRVAVVGAGYIAVEFAGvlnGLG 190
PRK06416 PRK06416
dihydrolipoamide dehydrogenase; Reviewed
 223-315 4.36e-04

dihydrolipoamide dehydrogenase; Reviewed


Pssm-ID: 235798 [Multi-domain]  Cd Length: 462  Bit Score: 41.67  E-value: 4.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616  223 GVAVLTGKKVVhldvrgnMVKLNDGSQ-ITFEKCLIATGGTPRSLSAIDRAGaevksrttlfRKIGD-FRALeKISREVK 300
Cdd:PRK06416 112 GEAKLVDPNTV-------RVMTEDGEQtYTAKNIILATGSRPRELPGIEIDG----------RVIWTsDEAL-NLDEVPK 173

                         90
                 ....*....|....*
gi 68005616  301 SITVIGGGFLGSELA 315
Cdd:PRK06416 174 SLVVIGGGYIGVEFA 188
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 246-320 1.35e-03

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 40.16  E-value: 1.35e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 68005616  246 DGSQITFEKCLIATGGTPRSLSAIDRA-GAEVKSRTTLFRkigdfraLEKISrevKSITVIGGGFLGSELACALGR 320
Cdd:PRK06292 125 NGERIEAKNIVIATGSRVPPIPGVWLIlGDRLLTSDDAFE-------LDKLP---KSLAVIGGGVIGLELGQALSR 190
PRK05249 PRK05249
Si-specific NAD(P)(+) transhydrogenase;
242-321 1.40e-03

Si-specific NAD(P)(+) transhydrogenase;


Pssm-ID: 235373 [Multi-domain]  Cd Length: 461  Bit Score: 40.14  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68005616  242 VKLNDGS--QITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTLfrkigdfraLEkISREVKSITVIGGGFLGSELAC--- 316
Cdd:PRK05249 126 VECPDGEveTLTADKIVIATGSRPYRPPDVDFDHPRIYDSDSI---------LS-LDHLPRSLIIYGAGVIGCEYASifa 195


                 ....*
gi 68005616  317 ALGRK 321
Cdd:PRK05249 196 ALGVK 200
vWA_transcription_factor_IIH_type cd01453
Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five ...
 47-121 4.28e-03

Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins contain a VWA domain. The p44 subunit of TFIIH functions as a DNA helicase in RNA polymerase II transcription initiation and DNA repair, and its transcriptional activity is dependent on its C-terminal Zn-binding domains. The function of the vWA domain is unclear, but may be involved in complex assembly. The MIDAS motif is not conserved in this sub-group.


Pssm-ID: 238730  Cd Length: 183  Bit Score: 37.70  E-value: 4.28e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68005616  47 LQMARQ----MASSGSsggkmdNSVLVLIVGLSTIGAGAYaYKTIKEdQKRYNERVMGLGLSPEEKQRRAIASATEGGS 121
Cdd:cd01453  92 LEMALEslkhMPSHGS------REVLIIFSSLSTCDPGNI-YETIDK-LKKENIRVSVIGLSAEMHICKEICKATNGTY 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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